Using an effective dose of 450 Gy, antioxidant effects of A.racemosus extract were studied against oxidative damage in terms of protection against lipid peroxidation, protein oxidation, depletion of protein thiols and the levels of the antioxidant enzyme, superoxide dismutase. An active fraction consisting of polysaccharides (termed as P3) was effective even at a low concentration of 10 μg/ml.
The inhibitory effects of these active principles, at the concentration of 10 μg/ml, are comparable to that of the established antioxidants glutathione and ascorbic acid. Hence our results indicate that extracts from A. racemosus have potent antioxidant properties in vitro in mitochondrial membranes of rat liver.
Anti-Ulcer -The present article includes the detailed exploration of ulcerprotective and healing effects of unripe plantain banana, tambrabhasma and Asparagus racemosus onvarious models of experimental gastroduodenal ulceration and patients with peptic ulcer. Their effects onmucin secretion, mucosal cell shedding, cell proliferation, anti-oxidant activity, glycoproteins, and PGsynthesis have been reported.
Their potential ulcer protective effects both, experimentaland clinical seemed to be due to their predominant effects on various mucosal defensive factors ratherthan on the offensive acid-pepsin secretion. Thus, the above herbal / herbo-mineral drugs do havepotential usefulness for treatment of peptic ulcer diseases.
Anti-Diarrhoeal - The present study was under-taken to evaluate the effect of ethanol and aqueous extracts of Asparagus racemosus for its antidiarrhoeal potential against several experimental models of diarrhea in Albino Wistar rats.
The anti-diarrhea activity of ethanol and aqueous extracts of Asparagus racemosus root was evaluated using castoroil-induced diarrhea model in rats. The plant extracts showed significant (P < 0.05) inhibitor activity against castor oil induced diarrhea and PGE2 induced enteropooling in rats when tested at 200 mg/kg.
The results point out the possible anti-diarrhoeal effect of the plant extracts and substantiate the use of this herbal remedy as a non-specific treatment for diarrhea in folk medicine
Thus, the anxiolytic response of MAR may involve GABA and serotonergic mechanisms. These preclinical datas show that AR can be a potential agent for treatment of anxiety disorders.
Anti-Diabetic - The present study was undertaken to investigate the effect of Asparagus racemosus Willd (Liliaceae) on streptozotocin -induced early diabetic nephropathy. The efficacy of extract was compared with diabetic control rats. A. racemosus treatment significantly decreased plasma glucose, creatinine, urea nitrogen, total cholesterol and triglyceride levels.
Results of this study suggested that A. racemosus has beneficial effect in the treatment of diabetic nephropathy.
Boost Immune System - The immunoadjuvant potential of Asparagus racemosus (Willd.) Family (Liliaceae) aqueous root extract was evaluated in experimental animals immunized with diphtheria, tetanus, pertussis (DTP) vaccine. Immunostimulation was evaluated using serological and hematological parameters.
Reduced mortality accompanied with overall improved health status was observed in treated animals after intra-cerebral challenge of B. pertussis indicating development of protective immune response. Present study indicates applications of test material as potential immunoadjuvant that also offers direct therapeutic benefits resulting in less morbidity and mortality.
Cough Remedy - The methanol extract of Asparagus racemosus root (200 and 400 mg/kg, p.o.) showed significant antitussive activity on sulfur dioxide-induced cough in mice, the cough inhibition (40.0 and 58.5%, respectively) being comparable to that of 10–20 mg/kg of codeine phosphate.
Anti-Inflammatory - Asparagus racemosus root extracts (AR) have been reported to possess a variety of pharmacological properties. The aim of the present study was to develop liposomes of AR and to assess their physicochemical characteristics and anti‑inflammatory activity in the monocytic leukemia cell line.
It can be concluded from the present study that AR liposomes have the potential to be used a formulation for topical and/or transdermal drug delivery to provide anti-inflammatory activity.
Alzheimer's Disease - The existing study displays that EEAR roots possesses an outstanding source for natural nootropic and confirming the traditional uses of this plant which could be industrialized for enhancing learning and memory impairment associated with neurodegenerative disorders particularly AD.