SHIPPING APRIL 15TH!!!

ZOMBIE CELL KILLER

News Articles:

•  Both Senolytic Molecules Are Inhibitors Of Particular Members Of The Bcl-2 Family Of Apoptosis Regulatory Proteins And Have Distinct Pharmacokinetic Profiles.
• ‘One Of The Most Important Aging Discoveries Ever’
• 100 Is The New 60: The Transformation Of Healthcare
• 12 Innovations That Could Make Reverse Aging A Reality
• 1St Age Reversal Results—Is It Hgh Or Something Else?
• 20 Technology Metatrends That Will Define The Next Decade
• 3 Most Important Breakthrough In Biology Of 2019
• 9 Ways To Stay Healthy As You Age
• A Cell-Killing Strategy To Slow Aging Passed Its First Test This Year
• A ‘One-Two Punch’ To Wipe Out Cancerous Ovarian Cells
• A True Fountain-Of-Youth Drug Combo?
• Advances In Antiaging Research: Chemistry Could Hold The Key To Better Health
• Advances In The Science Of Aging
• Ageing In Human Cells Successfully Reversed In The Lab
• Age-Related Enfeeblement Of The Immune System Speeds Build-Up Of Senescent Cells
• Anti-Ageing Drug On The Horizon: Scientists Discover Medicine Cocktail That Clears ‘Zombie Cells‘
• ‘Anti-Ageing‘ Drugs Could Be On The Market In Five Years If Clinical Trials Prove Successful
• Anti-Aging Drugs And Toxic Cells
• Anti-Aging Drugs Are Showing Promise In Human Trials
• Anti-Aging Drugs Could Be On The Market In The Next 5 Years
• Anti-Aging Field ‘Explodes’ In Pursuit Of Healthy Old Age
• Anti-Aging Mechanism May Hold Key To ‘Perfect’ Osteoporosis Treatment
• Anti-Aging Senolytic Cocktail Passes First Human Trial
• Anti-Aging Senolytics Drugs Found To Improve Mice Health And Lifespan
• Antibiotics Eliminate Senescent Cells Associated With Ageing
• Antoxerene Closes $10 Million Deal With Juvenescence To Develop Small Molecule Drugs For Diseases Of Aging
• Are Tauopathies Caused By Neuronal And Glial Senescence?
• Ascentage Pharma And Unity Biotechnology Announce Collaboration For The Development Of Senolytic Healthspan Therapies
• Ascentage Pharma, Unity Biotech Collab To ‘Cure Old Age’
• Can A Single Pill Keep You Healthy To 100?
• Can We Live Forever? | Feature
• Cell Aging In Lung Epithelial Cells
• Cellular Sickness Linked To Type 1 Diabetes Onset
• Clearing Old Cells From Mouse Brains Lowered Signs Of Anxiety
• Clearing Out Brain’S “Zombie Cells” Offers New Approach Against Dementia
• Concerns Rise Over Negative Impact Of Hev Light On Skin As Companies Delve Into Anti-Aging Therapeutics
• Could An Existing Heart Drug Help Treat Cancer?
• Could One Pill Cure A Host Of Diseases? Killing ‘Zombie‘ Cells To Improve Health In Old Age
• Cover Story: Investing In The Ageing Population Theme
• Diet, Physical Activity Among Keys To Healthy Brain
• Discovery Offers Hope For Improving Physical Performance As We Age
• Eat Glutathione
• Editor’S Letter: The Precision Medicine Issue
• Elixir Of Life: Scientists Find Way To Reverse Cell Damage Caused By Ageing
• Emerging Evidence Shows Wider Benefits Of Supplements
• Epigenetics And Aging
• Experts Propose New Healthcare Framework To Help Ageing Populations Stay Healthier Longer
• Extending Healthspan May Be Coming Soon
• Fascinating Picture Shows Anti-Ageing Drugs Really Do Work
• Finally, The Drug That Keeps You Young
• First-In-Human Trial Of Senolytic Drugs Encouraging
• Fisetin May Be An Effective Senolytic
• Fisetin Within Strawberries Clears Senescent Cells
• Fisetin—A New Senolytic
• Fountains Of Youth: Biotech Startups Emerge From Stealth Mode To ‘Take On Aging’
• Foxbio: $10M Jv Launched To Target Age-Related Disease
• Global Longevity And Anti-Senescence Therapy Market
• Global Longevity And Anti-Senescence Therapy Market 2019-2023 – Focus On Senolytic Drug Therapy, Gene Therapy, Immunotherapy And Others
• Herb Leaf Eaten By Japanese Samurai Found To Slow Down Ageing By Clearing Out Disease-Causing Cells
• Here Are 5 Things You Should Start Doing Today To Live Longer
• How Genome Sequencing And Senolytics Can Help Us Live Healthier, Longer
• How Silicon Valley Billionaires Claim They’Ve Discovered The Secret To Everlasting Life
• How This Man Genuinely Expects To Live To 200 (And Has Invested $100M To Discover The Secret)
• How To Live Longer: The Science Of Ageing, And How To Slow It Down
• Https://Endpts.Com/Harvard-Prof-David-Sinclair-Backs-Anti-Aging-Upstart-Life-Bio-Which-Just-Raised-50M-For-Research/
• Human Drug Trial In San Antonio Offers Hope To Those With Age-Related Diseases
• Humans ‘Biohacking’ Their Own Bodies With Blood Transfusions To Achieve ‘Diy Immortality’
• In Search For ‘Perfect’ Osteoporosis Treatment, Consider Key Anti-Aging Mechanism
• Ipf Treatment Options May Be Boosted By Senolytic Drugs
• Is Cellular Senescence The Key To Naked Mole Rats’ Long, Cancer-Free Life?
• Is Fasting Senolytic?
• Is Metformin The Key To Living Longer? | The Times Magazine
• Is The Cancer Drug Dasatinib The Anti-Aging Breakthrough We Have All Been Waiting For?
• Is There Any Truth To Anti-Aging Schemes?
• Journal Of The American Medical Association Shines Spotlight On Geroscience
• Juvenescence Closes First Tranche Of Series B Enabling Further Growth And Development
• Juvenescence Raises Another $100M To Invest In Longevity
• Kalter: Fountain Of Youth?
• Kidney Disease: Senescent Cell Burden Is Reduced In Humans By Senolytic Drugs
• Kill Senescent Cells Before They Kill You
• Killing ‘Zombie Cells‘ Cures Anxiety In Obese Mice
• Letter To An Incipient Cancer Survivor
• Life Biosciences Joins The Longevity Race
• Life Biosciences Raises $50M As Longevity Race Heats Up
• Life Biosciences: A New Paradigm For Approaching Longevity Research
• Lifespan Extended, Health Improved By Senolytic Drugs
• Link Between Aging, Devastating Lung Disease Discovered
• Link Between Cells Associated With Aging, Bone Loss
• Longevity And Anti-Senescence Therapy Market 2019 Global Analysis, Opportunities And Forecast To 2024
• Longevity And Anti-Senescence Therapy Market, 2023 – Emphasis On Stem Cell Research And Increasing Demand For Cell-Based Assays
• Longevity Company Unity Biotechnology Stocks Soared After Ceo Talks To Cnbc
• ‘Longevity‘ Could Reach Billions In 2019 – And Is No Longer Just The Preserve Of Billionaires
• Mayo Clinic Discovery Could Extend Quality Of Life
• Mayo Clinic May Be Onto The Fountain Of Youth
• Mayo Clinic Showcases Anti-Aging Senolytics
• Mayo Clinic Takes Next Step In Anti-Aging Research
• Molecule Kills Elderly Cells, Reduces Signs Of Aging In Mice
• Money In Aging Research, Part I
• Money In Aging Research, Part Ii
• Mouse Model Shows Success Of Senolytic Drugs In Reversing Senescent Cell Damage
• Natural Compounds That Remove Aging Cells
• Nature Medicine Study Describes A Novel Senolytic Molecule That Slows The Progression Of Osteoarthritis
• Never Grow Up: The Anti-Aging Market Is A $200B Industry
• New Cause Of Cell Aging Uncovered
• New Class Of ‘Transformative’ Anti-Aging Drugs Set For Human Trials
• Novato Startup Unity Biotechnology Tackles Arthritis, Glaucoma
• Obese Mice Lose Anxiety When ‘Zombie Cells‘ Exit Their Brain
• Osteoporosis: Potential New Drug Target Uncovered
• Parp Inhibitors Used In ‘One-Two Punch’ Strategy To Kill Oc Cells In Mouse Models, Study Shows
• Peninsula Anti-Aging Drug Company Files For $85M Ipo
• Plaques Age Glial Precursors, Stoking Inflammation
• Purging Failed Brain Insulation Cells Lessened Damage, Improved Cognition In Alzheimer’S Mouse Model
• Reducing ‘Zombie‘ Cells May Slow The Aging Process
• Rejuvenating Senolytics
• Rejuvenation At The Cell Level
• Removal Of ‘Zombie Cells‘ Alleviates Causes Of Diabetes In Obese Mice
• Removing “Zombie Fat Cells” A Way Forward For Treating Diabetes
• Research Shows It’S Possible To Reverse Damage Caused By Aging Cells
• Researchers Discover New Cause Of Cell Aging
• Researchers Discover Way To Slow Aging Process
• Researchers Identify Molecule With Anti-Aging Effects On Vascular System, Study Finds
• Researchers May Have Discovered”Fountain Of Youth” Drugs
• Restoring Brain Function In Mice With Symptoms Of Alzheimer’S Disease
• Rewinding The Clock
• Rumors Of Age Reversal: The Plasma Fraction Cure
• Scaling The Alzheimer’S Cure
• Scientists Discover Cell Aging Linked To Nucleotide Synthesis
• Scientists Harness Ai To Reverse Ageing In Billion-Dollar Industry
• Scientists Hunt Zombie Cells: ‘The Grand Challenge’
• Scientists Mark Success In First Human Test Of Novel Anti-Aging Therapy
• Scientists Pinpoint A Natural Compound That Helps Us Stave Off Aging
• Scientists Slow Ageing With Green Tea, Onions, Red Wine
• Scientists Take A Step Towards Beating The Pain Of Old Age
• Screening Method Identifies Compounds That Extend Lifespan In Mice
• Senescent Cell Burden Is Reduced In Humans By Senolytic Drugs
• Senescent Cell Research Moves Into Human Trials
• Senescent Cells May Play A Role In Thrombosis
• Senescent Cells Play An Essential Role In Wound Healing
• Senolytic Drugs Increase Lifespan, Improve Physical Function In Aging Mice | Medicine
• Senolytic Drugs May Offer New Ipf Therapy Options
• Senolytic Drugs May Reverse Damage Caused By Senescent Cells
• Senolytic Drugs Reverse Damage Caused By Senescent Cells In Mice
• Senolytic Therapeutics Kicks Off Q1 2019 With High-Profile Speaking Events
• Senolytic Therapeutics Y Quibim, Industria De La Longevidad Con Adn Valenciano
• Senolytic Therapies And The Quest To Cure Aging
• Senolytic Therapies For Healthy Longevity
• Senolytic Treatment Improves Physical Function In Ipf Patients, According To Small Pilot Study
• Senolytics Against Aging: Snapshot Of A Fast-Moving Field
• Senolytics Show Promise Against Alzheimer’S In Mice
• Senolytics: Living Healthier For Longer With A New Class Of Drugs
• Senolytics: Scientists Identify New Drug That Slows The Ageing Process And Could Dramatically Increase Our Life Expectancy
• Six Columbia Cancer Researchers Receive Seed Funding From Velocity
• ‘Sleeping Cells‘ Drive A Host Of Age-Related Diseases — And New Drugs Are Seeking To Rid Them From Our Bodies
• Steadman Philippon Research Institute To Share Four Dod Research Grants Aimed At Reducing Risk Of Osteoarthritis & Reducing Long-Term Disability Among Military Service Members And Veterans
• Study: Eating Red Meat May Not Be That Bad For You
• Sweep Away Senile Cells
• Targeting Senescent Cells Increases Bone Mass
• Tau Tangles Cleared By Senolytic Drugs In Alzheimer’S Mice
• The Biological Fountain Of Youth? ‘Anti-Aging’ Therapy Close To Clinical Trials
• The Ethics Of Anti-Ageing: Where Do We Draw The Line?
• The First Drugs Designed To Fight Aging Are Ready For Human Testing, Scientists Say
• The Future Of Aging: Bringing Hollywood To The Hospital
• The Longevity Industry Comes Of Age
• The Most Effective Personal Anti-Aging Program
• The Science Of Senolytics: How A New Pill Could Spell The End Of Ageing
• The Top 10 Companies Working To Increase Longevity
• The Transhumanists Who Want To Live Forever
• The War On Aging: An Update From The Front Lines – H+ Media
• The Wonder Drug That Could Reverse The Ageing Process
• This Drug Combo Extends Lifespan And Healthspan In Mice By Killing ‘Zombie’ Cells
• This Is An Important Step In Assessing The Role That A Senolytic Agent May Play In The Treatment Of Osteoarthritis
• This Russian Millionaire Wants To Help People Live To 200 Years Old
• To Stay Young, Kill Zombie Cells
• Top Companies Working To Extend Longevity
• Transfusions Of Young Blood Could Hold Key To Longer Life, Scientists Say
• Two Clinically-Approved Antibiotics Eliminate Senescent Cells Associated With Ageing
• Unity Takes Up Option On Ascentage Aging Drug
• Want To Live For Ever? Flush Out Your Zombie Cells
• What Is Fisetin? Product Found In Fruits And Vegetables May Slow Aging, Researchers Show
• What This Biotech’S $85 Million Ipo Tells Us About Raging Against Aging
• When Aging Is Fun
• Why A Drug For Aging Would Challenge Washington
• Why Jeff Bezos Is Backing This Silicon Valley Scientist Who Is Working On A Cure For Aging
• Why You Shouldn’T Fear The Gray Tsunami
• Will Age Soon Really Just Be A Number?
• Will We Soon Be Taking A Pill To Slow Aging?
• Wiping Out The Brain’S Retired Cells Prevents A Hallmark Of Alzheimer’S
• Wiping Out Zombie Cells In Fat May Delay Or Alleviate Diabetes
• Zombie Cell Research And Anxiety
• ‘Zombie Cells‘ Buildup In Your Body May Play Role In Aging

SCIENTIFIC STUDIES:

1. The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
2. The Clinical Potential of senolytic Drugs
3. Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
4. Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors
5. Clinical strategies and animal models for developing senolytic agents
6. senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo
7. Discovery of piperlongumine as a potential novel lead for the development of senolytic agents
8. Pleiotropic Effects of Tocotrienols and Quercetin on Cellular senescence: Introducing the Perspective of senolytic Effects of Phytochemicals
9. A Novel Indication for Panobinostat as a senolytic Drug in NSCLC and HNSCC
10. Oxidation resistance 1 is a novel senolytic target
11. Effects of senolytic drugs on human mesenchymal stromal cells
12. senolytic activity of piperlongumine analogues: Synthesis and biological evaluation
13. Hsp90 inhibitors as senolytic drugs to extend healthy aging
14. The curcumin analog EF24 is a novel senolytic agent
15. senolytic drugs in respiratory medicine: is it an appropriate therapeutic approach?
16. senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model
17. Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts
18. Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin
19. senolytic Cocktail Dasatinib+Quercetin (D+Q) Does Not Enhance the Efficacy of senescence-Inducing Chemotherapy in Liver Cancer
20. Emerging senolytic agents derived from natural products
21. senolytic treatments applied to osteoarthritis: a step towards the end of orthopedic surgery?
22. Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy
23. Curcumin and o-Vanillin Exhibit Evidence of senolytic Activity in Human IVD Cells In Vitro
24. senolytic helpers
25. senolytic therapies for healthy longevity
26. Removing Aging Cells With a New Class of senolytic Drug
27. Quercetin in Idiopathic Pulmonary Fibrosis: Another Brick in the senolytic Wall
28. SAT0053 Identification of novel drugs with senolytic activity as osteoarthritis therapeutics
29. Abstract 11299: A Novel senolytic Drug for Aging and Age-Related Cardiometabolic Disorders
30. Novel Classification Perspective of Geroprotective and senolytic Drugs as an Antiaging Strategy
31. LSC – 2017 – senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo
32. senolytic treatment targets aberrant p21-expression to restore liver regeneration in adult mice
33. Augmented Inflammatory Responses in Aging are Driven by Circulating mtDNA and Ameliorated by senolytic Treatment
34. senescence Signature in Skin Biopsies From Systemic Sclerosis Patients Treated With senolytic Therapy: Potential Predictor of Clinical Response?
35. Fenofibrate, a peroxisome proliferator-activated receptor alpha, is a novel molecule with senolytic and autophagy activity for cartilage degeneration and osteoarthritis
36. senolytic activity of small molecular polyphenols from olive restores chondrocyte redifferentiation and cartilage regeneration in osteoarthritis
37. Treatment of parkinson’s disease and other conditions caused or mediated by senescent astrocytes using small molecule senolytic agents
38. Application of ex-vivo spheroid model system for the analysis of senescence and senolytic phenotypes in uterine leiomyoma
39. AMPK-mediated senolytic and senostatic activity of quercetin surface functionalized Fe3O4 nanoparticles during oxidant-induced senescence in human fibroblasts
40. Mitochondrial DNA-Mediated Inflammatory Injury in Old Donors Is Improved by senolytic Treatment
41. The biology of senescence.
42. Leaf senescence
43. Cellular senescence in Aging Primates
44. senescence in premalignant tumours
45. senescence mechanisms
46. Cancer, aging and cellular senescence.
47. The essence of senescence
48. Four faces of cellular senescence
49. Microarray analysis of replicative senescence
50. Aging, Cellular senescence, and Cancer
51. Molecular aspects of leaf senescence
52. Cellular senescence in Cancer and Aging
53. Making Sense of senescence (Molecular Genetic Regulation and Manipulation of Leaf senescence).
54. Pleiotropy, Natural Selection, and the Evolution of senescence
55. Cellular senescence as a tumor-suppressor mechanism
56. Ageing. The biology of senescence.
57. CHLOROPHYLL DEGRADATION DURING senescence*
58. The moulding of senescence by natural selection
59. The molecular biology of leaf senescence
60. Gene expression during leaf senescence
61. A new murine model of accelerated senescence
62. The biology of replicative senescence
63. The senescence of leaves.
64. A DNA damage checkpoint response in telomere-initiated senescence
65. Cellular senescence: from physiology to pathology
66. Putting the stress on senescence
67. Rapamycin decelerates cellular senescence
68. Inhibition of Leaf senescence by Autoregulated Production of Cytokinin
69. senescence and Postharvest Physiology
70. Free radicals and senescence
71. Cellular senescence: when bad things happen to good cells
72. Bmi1, stem cells, and senescence regulation
73. The signals and pathways activating cellular senescence
74. senescence-accelerated mouse (SAM): A novel murine model of senescence
75. Testosterone Secretion and Metabolism in Male senescence
76. senescence in Plant Development
77. Catalase, Peroxidase, and Polyphenoloxidase Activities during Rice Leaf senescence
78. Replicative senescence: An Old Lives’ Tale?
79. Transcriptome of Arabidopsis leaf senescence
80. Nitrogen metabolism and remobilization during senescence
81. Tumor Cell senescence in Cancer Treatment
82. senescence Induced by Altered Telomere State, Not Telomere Loss
83. senescence of Activated Stellate Cells Limits Liver Fibrosis
84. Telomeres, telomerase and senescence
85. LABORATORY EVOLUTION OF POSTPONED senescence IN DROSOPHILA MELANOGASTER
86. Defining senescence and death
87. Chemokine Signaling via the CXCR2 Receptor Reinforces senescence
88. FUNGAL senescence
89. Telomeres, stem cells, senescence, and cancer
90. Replicative senescence: the human fibroblast comes of age
91. Evolution of senescence: late survival sacrificed for reproduction
92. Cellular senescence
93. SELECTION FOR DELAYED senescence IN DROSOPHILA MELANOGASTER
94. senescence in tumours: evidence from mice and humans
95. Fat tissue, aging, and cellular senescence
96. Inflammatory networks during cellular senescence: causes and consequences
97. senescence
98. Role of Ceramide in Cellular senescence
99. senescence of human fibroblasts induced by oncogenic Raf
100. Ethylene and flower senescence
101. Cell senescence and cancer
102. Therapy-Induced senescence in Cancer
103. Genes involved in senescence and immortalization
104. BRAFE600-associated senescence-like cell cycle arrest of human naevi
105. Vascular Cell senescence
106. Reversible inhibition of tomato fruit senescence by antisense RNA
107. A senescent cell bystander effect: senescence‐induced senescence
108. Molecular regulation of leaf senescence
109. senescence in a Bacterium with Asymmetric Division
110. senescence-messaging secretome: SMS-ing cellular stress
111. Leaf senescence
112. senescence, Apoptosis or Autophagy?
113. senescence and immortalization: role of telomeres and telomerase
114. senescence‐Accelerated Mouse (SAM): A Novel Murine Model of Accelerated senescence
115. Regulation of cellular senescence by p53
116. If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells
117. senescence.7.aspx”>Oxidation and erythrocyte senescence
118. Formation of MacroH2A-Containing senescence-Associated Heterochromatin Foci and senescence Driven by ASF1a and HIRA
119. Oncogene-induced senescence as an initial barrier in lymphoma development
120. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
121. Tumor suppressors and oncogenes in cellular senescence
122. senescence in human intervertebral discs
123. Oncogene-Induced senescence Relayed by an Interleukin-Dependent Inflammatory Network
124. Cellular senescence and its effector programs
125. 15 – Whole Plant senescence
126. Cellular senescence and organismal aging
127. senescence-Associated Gene Expression during Ozone-Induced Leaf senescence in Arabidopsis
128. Human senescence
129. senescence impairs successful reprogramming to pluripotent stem cells
130. Oncogenic ras Provokes Premature Cell senescence Associated with Accumulation of p53 and p16INK4a
131. Programmed Cell senescence during Mammalian Embryonic Development
132. Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
133. The case for negative senescence
134. Methods to Detect Biomarkers of Cellular senescence
135. senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
136. senescence‐associated β‐galactosidase is lysosomal β‐galactosidase
137. Akt Determines Replicative senescence and Oxidative or Oncogenic Premature senescence and Sensitizes Cells to Oxidative Apoptosis
138. Deferral of Leaf senescence with Calcium
139. Experimental Modification of Plant senescence.
140. The Activated Oxygen Role of Peroxisomes in senescence
141. Aging, articular cartilage chondrocyte senescence and osteoarthritis
142. PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
143. Pro-senescence therapy for cancer treatment
144. senescence comes of age
145. The senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
146. Oxidative DNA damage and senescence of human diploid fibroblast cells
147. senescence surveillance of pre-malignant hepatocytes limits liver cancer development
148. Extreme heat effects on wheat senescence in India
149. Cellular senescence: putting the paradoxes in perspective
150. Cellular senescence and cancer treatment
151. Calcium in plant senescence and fruit ripening
152. An alternative pathway for yeast telomere maintenance rescues est1− senescence
153. THE TWO-STAGE MECHANISM CONTROLLING CELLULAR senescence AND IMMORTALIZATION
154. Ethylene, Plant senescence and Abscission
155. The molecular genetic analysis of leaf senescence
156. Hallmarks of senescence in carcinogenesis and cancer therapy
157. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
158. Homocysteine accelerates endothelial cell senescence
159. The molecular analysis of leaf senescence – a genomics approach
160. A Cellular Timetable of Autumn senescence
161. MicroRNA-34a regulation of endothelial senescence
162. Involvement of Hydrogen Peroxide in the Regulation of senescence in Pear
163. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
164. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
165. Deconstructing PML-induced premature senescence
166. Mortality Patterns Suggest Lack of senescence in Hydra
167. Plant senescence processes and free radicals
168. Role of oxidative carbonylation in protein quality control and senescence
169. Measuring Wheat senescence with a Digital Camera
170. Brain acetylcholine synthesis declines with senescence
171. Human cell senescence as a DNA damage response
172. Molecular genetics of leaf senescence in Arabidopsis
173. Development and senescence of the Postnatal Bovine Ovary
174. Leaf senescence in Brassica napus: cloning of senescence related genes by subtractive hybridisation
175. Alveolar Cell senescence in Patients with Pulmonary Emphysema
176. Functional senescence in Drosophila melanogaster
177. Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity
178. The evolutionary ecology of senescence
179. Replicative senescence: Implications for in Vivo Aging and Tumor Suppression
180. SASP reflects senescence
181. Ethylene regulates the timing of leaf senescence in Arabidopsis
182. Cellular senescence, cancer and aging: the telomere connection
183. Control of Jasmonate Biosynthesis and senescence by miR319 Targets
184. Replicative senescence of Mesenchymal Stem Cells: A Continuous and Organized Process
185. T-helper-1-cell cytokines drive cancer into senescence
186. Cellular senescence and tumor suppressor gene p16
187. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
188. Telomeres and senescence: Ending the Debate
189. Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular senescence
190. The aging brain: morphomolecular senescence of cortical circuits
191. Reversal of human cellular senescence: roles of the p53 and p16 pathways
192. Molecular analysis of natural leaf senescence in Arabidopsis thaliana
193. A transcriptional timetable of autumn senescence
194. Cellular senescence and cancer
195. Human SIR2 deacetylates p53 and antagonizes PML/p53‐induced cellular senescence
196. Telomere dysfunction and tumour suppression: the senescence connection
197. Many roads lead to oncogene-induced senescence
198. A negative feedback signaling network underlies oncogene-induced senescence
199. The anemia of senescence
200. Plant senescence and crop productivity
201. Replicative senescence: a critical review
202. senescence in Health and Disease
203. A NAC Gene Regulating senescence Improves Grain Protein, Zinc, and Iron Content in Wheat
204. Last exit: senescence, abscission, and meristem arrest in Arabidopsis.
205. Memory loss in senescence.
206. Cigarette Smoke Induces Cellular senescence
207. Rethinking Chronic Allograft Nephropathy
     The Concept of Accelerated senescence
208. The sound of senescence
209. Oncogenic Braf Induces Melanocyte senescence and Melanoma in Mice
210. What has senescence got to do with cancer?
211. Targets of AtWRKY6 regulation during plant senescence and pathogen defense
212. Telomerase, senescence and ageing
213. Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat.
214. PML is induced by oncogenic ras and promotes premature senescence
215. The senescence-Induced Staygreen Protein Regulates Chlorophyll Degradation
216. Bypass of senescence After Disruption of p21CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts
217. Differential expression of senescence-associated mRNAs during leaf senescence induced by different senescence-inducing factors in Arabidopsis
218. Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts.
219. An attempt to prevent senescence: A mitochondrial approach
220. Delayed leaf senescence induces extreme drought tolerance in a flowering plant
221. senescence and Rejuvenation
222. Forging a signature of in vivo senescence
223. Evolutionary and Nonevolutionary Theories of senescence
224. Cellular senescence revisited: a review
225. Living on a break: cellular senescence as a DNA-damage response
226. senescence in the whole plant.
227. Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for senescence?
228. Geriatric muscle stem cells switch reversible quiescence into senescence
229. Physiology and molecular biology of petal senescence
230. Endothelial Cell senescence in Human Atherosclerosis
231. Telomere positional effects and the regulation of cellular senescence
232. Role of Ethylene in senescence of Petals—Morphological and Taxonomical Relationships
233. Paradoxical suppression of cellular senescence by p53
234. Evidence Supporting a Role of Jasmonic Acid in Arabidopsis Leaf senescence
235. Prohibitin: Potential role in senescence, development, and tumor suppression
236. senescence and aging: the critical roles of p53
237. senescence as a mode of tumor suppression.
238. Large‐scale identification of leaf senescence‐associated genes
239. NK and NK/T cells in human senescence
240. Vascular endothelial senescence: from mechanisms to pathophysiology
241. Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence.
242. When cells get stressed: an integrative view of cellular senescence
243. A mutant with a defect in telomere elongation leads to senescence in yeast
244. Selenium – an antioxidative protectant in soybean during senescence
245. Oncogene-Induced senescence: Putting the Brakes on Tumor Development
246. The power and the promise of oncogene-induced senescence markers
247. The role of chondrocyte senescence in osteoarthritis
248. OSTEOPOROSIS : DISEASE OR senescence ?
249. The pathobiology of Parkinson’s disease: biochemical aspects of dopamine neuron senescence.
250. A complex secretory program orchestrated by the inflammasome controls paracrine senescence
251. Growth, Maturation, and senescence in Fruits
252. ORE9, an F-Box Protein That Regulates Leaf senescence in Arabidopsis
253. Cell senescence and hypermitogenic arrest
254. Cellular senescence mediates fibrotic pulmonary disease
255. Accelerated immune senescence and HIV-1 infection
256. senescence of leafy vegetables
257. Mitotic and postmitotic senescence in plants.
258. NaCl-induced senescence in Leaves of Rice (Oryza sativaL.) Cultivars Differing in Salinity Resistance
259. Erosion of the telomeric single-strand overhang at replicative senescence
260. Mechanisms of cellular senescence in human and mouse cells
261. Loss of ‘Complexity’ and AgingPotential Applications of Fractals and Chaos Theory to senescence
262. Id proteins in cell cycle control and cellular senescence
263. A role for both RB and p53 in the regulation of human cellular senescence
264. Physiological significance of anthocyanins during autumnal leaf senescence
265. Lamin B1 loss is a senescence-associated biomarker
266. Isolation and Identification of a senescence-promoting Substance from Wormwood (Artemisia absinthium L.)
267. Oxidative stress and antioxidant activity as the basis of senescence in maize leaves
268. Nutrients mobilized from leaves of Arabidopsis thaliana during leaf senescence
269. Ethylene in Plant Growth, Development, and senescence
270. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes
271. Ras Proteins Induce senescence by Altering the Intracellular Levels of Reactive Oxygen Species
272. Flower senescence in daylily (Hemerocallis)
273. Role of Oxidative Stress in Telomere Length Regulation and Replicative senescence
274. Leaf senescence: Correlated with Increased Levels of Membrane Permeability and Lipid Peroxidation, and Decreased Levels of Superoxide Dismutase and Catalase
275. Deletion of Ku86 causes early onset of senescence in mice
276. senescence, apoptosis and therapy — cutting the lifelines of cancer
277. Cellular senescence: A Translational Perspective
278. senescence-accelerated mouse (SAM): a biogerontological resource in aging research
279. The timing of maize leaf senescence and characterisation of senescence‐related cDNAs
280. Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence
281. Human melanocyte senescence and melanoma susceptibility genes
282. UV-C treatment delays postharvest senescence in broccoli florets
283. Processes and control of plant senescence.
284. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
285. Pollination-induced flower senescence: a review
286. Structure elucidation of a senescence cross-link from human extracellular matrix. Implication of pentoses in the aging process.
287. Oncogene-Induced Cell senescence — Halting on the Road to Cancer
288. Mitochondrial Dysfunction Contributes to Oncogene-Induced senescence
289. Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence
290. Cell cycle arrest is not senescence
291. Proteolytic activity during senescence of plants
292. senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
293. senescence IN NATURAL POPULATIONS OF MAMMALS: A COMPARATIVE STUDY
294. Grading score system: A method for evaluation of the degree of senescence in senescence Accelerated Mouse (SAM)
295. Oncogenic ras and p53 Cooperate To Induce Cellular senescence
296. senescence, Abscission and Cellulase Activity in Phaseolus vulgaris
297. Oncogenic BRAF Induces senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7
298. Early Immune senescence in HIV Disease
299. The role of senescence and immortalization in carcinogenesis
300. Leaf senescence: Signals, Execution, and Regulation
301. Cellular senescence and chromatin structure
302. Cellular senescence in vivo: a barrier to tumorigenesis
303. Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells,
304. The shaping of senescence in the wild
305. Molecular Dissection of Formation of senescence-Associated Heterochromatin Foci
306. Short Telomeres Limit Tumor Progression In Vivo by Inducing senescence
307. Zeb1 links epithelial-mesenchymal transition and cellular senescence
308. Cellular senescence controls fibrosis in wound healing
309. Jasmonates: Hormonal regulators or stress factors in leaf senescence?
310. Effect of extrinsic mortality on the evolution of senescence in guppies
311. Replicative senescence and Oxidant‐Induced Premature senescence: Beyond the Control of Cell Cycle Checkpoints
312. Mitochondrial Dysfunction Accounts for the Stochastic Heterogeneity in Telomere-Dependent senescence
313. Immunologic Deficiencies in senescence
314. Telomeres and senescence: The history, the experiment, the future
315. A senescence Program Controlled by p53 and p16INK4a Contributes to the Outcome of Cancer Therapy
316. senescence As an Anticancer Mechanism
317. Changes in antioxidative enzymes in cucumber cotyledons during natural senescence: comparison with those during dark‐induced senescence
318. senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells
319. MicroRNA 217 Modulates Endothelial Cell senescence via Silent Information Regulator 1
320. The Role of Cellular senescence in Skin Aging
321. Identification of three genetic loci controlling leaf senescence in Arabidopsis thaliana
322. Pathobiology of the senescence-accelerated mouse (SAM)
323. Biochemistry of senescence
324. Optimization of edible coating composition to retard strawberry fruit senescence
325. Population cycles in microtines: The senescence hypothesis
326. Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion?
327. In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs
328. Mitochondria: are they the seat of senescence?
329. senescence of red blood cells: progress and problems
330. Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis.
331. T cell senescence.
332. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
333. Escape from senescence in human diploid fibroblasts induced directly by mutant p53.
334. senescence, ageing and death of the whole plant
335. Reactive Oxygen Species as Mediators of Cellular senescence
336. TAp63 induces senescence and suppresses tumorigenesis in vivo
337. p53, ROS and senescence in the control of aging
338. Cellular senescence in aging and age-related disease: from mechanisms to therapy
339. Cellular senescence: hot or what?
340. Microglial senescence: does the brain’s immune system have an expiration date?
341. A genetic analysis of senescence in Drosophila
342. Non‐destructive optical detection of pigment changes during leaf senescence and fruit ripening
343. Role of CMV in immune senescence
344. JunD Protects Cells from p53-Dependent senescence and Apoptosis
345. MORPHOLOGIC CHANGES ACCOMPANYING senescence OF CULTURED HUMAN DIPLOID CELLS
346. Quantitative assessment of markers for cell senescence
347. Caspase inhibition switches doxorubicin-induced apoptosis to senescence
348. Replicative senescence of human fibroblast-like cells in culture
349. Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis
350. A senescence-associated gene of Arabidopsis thaliana is distinctively regulated during natural and artificially induced leaf senescence
351. Impact of cellular senescence signature on ageing research
352. DNA damage response and cellular senescence in tissues of aging mice
353. Lack of Replicative senescence in Normal Rodent Glia
354. Peroxisome senescence in Human Fibroblasts
355. Effects of estrogen on growth plate senescence and epiphyseal fusion
356. DNA damage, cellular senescence and organismal ageing: causal or correlative?
357. Lack of Replicative senescence in Cultured Rat Oligodendrocyte Precursor Cells
358. Human Platelet senescence
359. Feedback between p21 and reactive oxygen production is necessary for cell senescence
360. Oncogene-Induced senescence Pathways Weave an Intricate Tapestry
361. A Role for Diacylglycerol Acyltransferase during Leaf senescence
362. senescence-induced RNases in tomato
363. Identification of a transcription factor specifically expressed at the onset of leaf senescence
364. PRAK Is Essential for ras-Induced senescence and Tumor Suppression
365. Relation between leaf senescence and stomatal closure: senescence in light
366. Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I—effects of proliferative senescence
367. Total body irradiation selectively induces murine hematopoietic stem cell senescence
368. Is Petal senescence Due to Sugar Starvation?
369. senescence and apoptosis: dueling or complementary cell fates?
370. Cellular senescence as a tumor-protection mechanism: the essential role of counting
371. AtNAP, a NAC family transcription factor, has an important role in leaf senescence
372. Metabolism of Oat Leaves during senescence
     V. senescence in Light
373. Leaf senescence in rice plants: cloning and characterization of senescence up‐regulated genes
374. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
375. Memory T cell homeostasis and senescence during aging
376. Natal dispersal and senescence
377. Cell wall metabolism during maturation, ripening and senescence of peach fruit
378. senescence, sleep, and circadian rhythms
379. Neurologic Signs in senescence
380. Genetic regulation of embryo death and senescence
381. Lysosome-mediated processing of chromatin in senescence
382. The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence
383. senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning
384. Inside and out: the activities of senescence in cancer
385. p16Ink4a in Melanocyte senescence and Differentiation
386. Replicative senescence of human endothelial cells in vitro involves G1 arrest, polyploidization and senescence-associated apoptosis
387. Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas
388. Autophagy facilitates oncogene-induced senescence
389. Cellular senescence: A link between cancer and age-related degenerative disease?
390. senescence‐associated intrinsic mechanisms of osteoblast dysfunctions
391. Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer
392. Secretion of Vascular Endothelial Growth Factor by Primary Human Fibroblasts at senescence
393. Transcription factors regulating leaf senescence in Arabidopsis thaliana
394. Expression of senescence‐enhanced genes in response to oxidative stress
395. A Phylogenetic Evaluation of Whether Endophytes Become Saprotrophs at Host senescence
396. Mitochondria, telomeres and cell senescence
397. Mechanisms, Functional Consequences, and Potential Therapeutics for Cellular senescence
398. Evidence for programmed cell death during leaf senescence in plants [1998]
399. senescence: a new weapon for cancer therapy
400. Ethylene Production During senescence of Flowers
401. Die and let live: leaf senescence contributes to plant survival under drought stress
402. Astrocyte senescence as a Component of Alzheimer’s Disease
403. Alcohols and Carnation senescence
404. AGE‐SPECIFIC SURVIVAL IN FIVE POPULATIONS OF UNGULATES: EVIDENCE OF senescence
405. Fibroblast senescence in pressure ulcers
406. Mental efficiency in senescence.
407. Chloroplasts regulate leaf senescence: delayed senescence in transgenic ndhF-defective tobacco
408. Retarded senescence in an insular population of Virginia opossums (Didelphis virginiana)
409. Ink4a/Arf links senescence and aging
410. Retardation of radish leaf senescence by polyamines
411. Salicylic acid has a role in regulating gene expression during leaf senescence
412. DNA Damage Is Able to Induce senescence in Tumor Cells in Vitro and in Vivo
413. Hormone receptor changes during adulthood and senescence: significance for aging research.
414. Vascular smooth muscle cell senescence in atherosclerosis
415. How might replicative senescence contribute to human ageing?
416. Age-related changes in learning and memory in the senescence-accelerated mouse (SAM)
417. Angiotensin II accelerates endothelial progenitor cell senescence through induction of oxidative stress
418. INDIVIDUAL DIFFERENCES, LONGEVITY, AND REPRODUCTIVE senescence IN BIGHORN EWES
419. DNA damage checkpoint kinase Chk2 triggers replicative senescence
420. Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and senescence
421. Targets of the WRKY53 transcription factor and its role during leaf senescence in Arabidopsis
422. Reversal of senescence in Mouse Fibroblasts through Lentiviral Suppression of p53
423. senescence‐associated proteases in plants
424. Cigarette Smoke Induces senescence in Alveolar Epithelial Cells
425. senescence-Associated Exosome Release from Human Prostate Cancer Cells
426. Aging and Cancer: The Double‐Edged Sword of Replicative senescence
427. The evolution of premature reproductive senescence and menopause in human females
428. senescence of an Antibody-forming Cell Clone
429. miR-22 represses cancer progression by inducing cellular senescence
430. Telomerase Inhibition, Telomere Shortening, and senescence of Cancer Cells by Tea Catechins
431. cGAS is essential for cellular senescence
432. Effect of Kinetin on Protein & Nucleic Acid Metabolism in Xanthium Leaves During senescence
433. A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
434. Retardation of the senescence of Cultured Human Diploid Fibroblasts by Carnosine
435. Plant senescence
436. Immune Activation and CD8+ T-Cell Differentiation towards senescence in HIV-1 Infection
437. Telomere Shortening Triggers senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a
438. Mitogen‐activated protein kinase p38 defines the common senescence‐signalling pathway
439. Werner syndrome protein limits MYC-induced cellular senescence
440. Identification of senescence-associated genes from daylily petals
441. Cellular senescence in naevi and immortalisation in melanoma: a role for p16?
442. Leaf senescence and nutrient remobilisation in barley and wheat
443. Stay-green regulates chlorophyll and chlorophyll-binding protein degradation during senescence
444. Overcoming cellular senescence in human cancer pathogenesis
445. The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing
446. PHOTOCONTROL OF LEAF senescence
447. Hallmarks of Cellular senescence
448. Inhibition of p21‐mediated ROS accumulation can rescue p21‐induced senescence
449. Vascular cell senescence and vascular aging
450. The p16INK4a-RB pathway : molecular link between cellular senescence and tumor suppression
451. T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment
452. Loss of linker histone H1 in cellular senescence
453. Fibroblasts cultured from venous ulcers display cellular characteristics of senescence
454. senescence and programmed cell death: substance or semantics?
455. Rapid induction of senescence in human cervical carcinoma cells
456. Networking senescence-Regulating Pathways by Using Arabidopsis Enhancer Trap Lines
457. Synthetic lethal metabolic targeting of cellular senescence in cancer therapy
458. DOES INCREASED MORTALITY FAVOR THE EVOLUTION OF MORE RAPID senescence?
459. Relation between senescence and stomatal opening: senescence in darkness
460. Measuring senescence in wild animal populations: towards a longitudinal approach
461. Cell senescence in the Aging Kidney
462. p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC
463. Replicative senescence and Cell Immortality: The Role of Telomeres and Telomerase
464. Cellular senescence, ageing and disease
465. Effect of sugar-induced senescence on gene expression and implications for the regulation of senescence in Arabidopsis
466. Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis
467. Victorin Induction of an Apoptotic/senescence–like Response in Oats
468. The oxidative hypothesis of senescence
469. Accumulation of Short Telomeres in Human Fibroblasts Prior to Replicative senescence
470. Stress-induced Premature senescence (SIPS)
471. Significant Role for p16INK4a in p53-Independent Telomere-Directed senescence
472. Is β-Galactosidase Staining a Marker of senescence in Vitro and in Vivo?
473. Role of polyamines and ethylene as modulators of plant senescence
474. Aging and Immortality: Quasi-Programmed senescence and Its Pharmacologic Inhibition
475. Ovarian Dynamics in Heliconiine Butterflies: Programmed senescence versus Eternal Youth
476. Inflammatory signaling and cellular senescence
477. PROTEIN SYNTHESIS AND DEGRADATION DURING AGING AND senescence
478. Extracellular Invertase Is an Essential Component of Cytokinin-Mediated Delay of senescence
479. Physical activity and immune senescence in men.
480. Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence
481. Mitochondrial Dysfunction Induces senescence with a Distinct Secretory Phenotype
482. Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast
483. Regulation of mitochondrial respiration in senescence
484. Induction of EMT by Twist Proteins as a Collateral Effect of Tumor-Promoting Inactivation of Premature senescence
485. Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced senescence
486. Role of Cytokinins in Carnation Flower senescence
487. Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes
488. The roles of senescence and telomere shortening in cardiovascular disease
489. Vertical saccades in senescence.
490. Variations in senescence and Longevity Include the Possibility of Negligible senescence
491. Lipid turnover during senescence
492. Mechanisms of endothelial senescence
493. Natural senescence of Pea Leaves (An Activated Oxygen-Mediated Function for Peroxisomes)
494. Water Stress during Seed Filling and Leaf senescence in Soybean
495. Stress-induced premature senescence and tissue ageing
496. Increase of deleted mitochondrial DNA in the striatum in Parkinson’s disease and senescence
497. Defining cellular senescence in IMR-90 cells: a flow cytometric analysis
498. Cellular senescence mechanisms in chronic wound healing
499. Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation
500. The role of CD8+ T‐cell replicative senescence in human aging
501. Telomere Erosion and senescence in Human Articular Cartilage Chondrocytes
502. Cellular senescence and DNA synthesis: Thymidine incorporation as a measure of population age in human diploid cells
503. A Novel Role for High-Mobility Group A Proteins in Cellular senescence and Heterochromatin Formation
504. Healing and Hurting: Molecular Mechanisms, Functions, and Pathologies of Cellular senescence
505. Signal transduction in leaf senescence
506. senescence in seeds.
507. Growth stimulation leads to cellular senescence when the cell cycle is blocked
508. Epidermal differentiation, apoptosis, and senescence: common pathways?
509. Cellular senescence in the glaucomatous outflow pathway
510. Leaf senescence Is Delayed in Tobacco Plants Expressing the Maize Homeobox Gene knotted1 under the Control of a senescence-Activated Promoter
511. Induction of cellular senescence in immortalized cells by human chromosome 1
512. senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells
513. Stabilization of Oat Leaf Protoplasts through Polyamine-mediated Inhibition of senescence
514. Androgens in male senescence
515. Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4a
516. Mitogenic signalling and the p16INK4a–Rb pathway cooperate to enforce irreversible cellular senescence
517. Programmed Cell Death during Pollination-Induced Petal senescence in Petunia
518. Developmental and age-related processes that influence the longevity and senescence of photosynthetic tissues in arabidopsis.
519. Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?
520. Reactive oxygen species and oxidative burst: Roles in stress, senescence and signal transducation in plants
521. Molecular and Biochemical Characterization of Postharvest senescence in Broccoli
522. TWIN STUDIES ON senescence
523. senescence of the Human Immune System
524. Longevity and senescence in plants
525. senescence‐specific regulation of catalases in Arabidopsis thaliana (L.) Heynh
526. Extended culture of mouse embryo cells without senescence: inhibition by serum
527. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes
528. Desiccation, Flight, Glycogen, and Postponed senescence in Drosophila metanogaster
529. Klotho as a regulator of oxidative stress and senescence
530. Twisted epithelial–mesenchymal transition blocks senescence
531. BENZYLADENINE EFFFCTS ON BEAN LEAF GROWTH AND senescence
532. The Strategy of senescence
533. Differences in gene expression between natural and artificially induced leaf senescence
534. Aging and Replicative senescence Have Related Effects on Human Stem and Progenitor Cells
535. Requirement for p27KIP1 in Retinoblastoma Protein-Mediated senescence
536. Replicative senescence in Human Uroepithelial Cells
537. MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
538. Superoxide Dismutase 1 Knock-down Induces senescence in Human Fibroblasts
539. Cellular senescence in vivo: Its relevance in ageing and cardiovascular disease
540. Evolutionary Perspectives on Human senescence
541. T Cell Replicative senescence in Human Aging
542. Possible Mechanisms of Adaptive Leaf senescence
543. Sorghum stay-green QTL individually reduce post-flowering drought-induced leaf senescence
544. senescence Mutants of Saccharomyces cerevisiae With a Defect in Telomere Replication Identify Three Additional EST Genes
545. senescence AND REPRODUCTIVE VALUE IN SPARROWHAWKS
546. Understanding insect life histories and senescence through a resource allocation lens
547. Klotho suppresses RIG-I-mediated senescence-associated inflammation
548. Cardiac Muscle Changes in senescence
549. Ethylene as a Regulator of senescence in Tobacco Leaf Discs
550. Aspirin reduces endothelial cell senescence
551. senescence IN NATURAL POPULATIONS OF MAMMALS: A REANALYSIS
552. Growth and senescence of antibody‐forming cells
553. Regulation of a senescence Checkpoint Response by the E2F1 Transcription Factor and p14ARF Tumor Suppressor
554. INK4a-de®cient human diploid ®broblasts areresistant to RAS-induced senescence
555. Response of a primary human fibroblast cell line to H2O2: senescence-like growth arrest or apoptosis?
556. A senescence-like Phenotype Distinguishes Tumor Cells That Undergo Terminal Proliferation Arrest after Exposure to Anticancer Agents
557. Cdk2 suppresses cellular senescence induced by the c-myc oncogene
558. Identification of a promoter region responsible for the senescence-specific expression of SAG12
559. Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix
560. ANTAGONISTIC PLEIOTROPY, MORTALITY SOURCE INTERACTIONS, AND THE EVOLUTIONARY THEORY OF senescence
561. Wound chronicity and fibroblast senescence – implications for treatment
562. Insect thermal tolerance: what is the role of ontogeny, ageing and senescence?
563. THE CORRELATION BETWEEN OXIDATIVE STRESS AND LEAF senescence DURING PLANT DEVELOPMENT #
564. p38MAPK is a novel DNA damage response‐independent regulator of the senescence‐associated secretory phenotype
565. Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells
566. Effect of Pod Removal on Leaf senescence in Soybeans
567. On the senescence of ovules in cherries
568. OsNAP connects abscisic acid and leaf senescence by fine-tuning abscisic acid biosynthesis and directly targeting senescence-associated genes in rice
569. Acceleration of senescence in the collared flycatcher Ficedula albicollis by reproductive costs
570. Rapid and costly ageing in wild male flies
571. Transcription Analysis of Arabidopsis Membrane Transporters and Hormone Pathways during Developmental and Induced Leaf senescence
572. Role of p14ARF in Replicative and Induced senescence of Human Fibroblasts
573. Leaf senescence and Starvation-Induced Chlorosis Are Accelerated by the Disruption of an Arabidopsis Autophagy Gene
574. The Role of Protein Synthesis in the senescence of Leaves
575. Emergence, Elongation, and senescence of Maize Silks
576. Hemangioblastic Derivatives from Human Induced Pluripotent Stem Cells Exhibit Limited Expansion and Early senescence
577. Immune senescence
578. Glucose-Induced Replicative senescence in Mesenchymal Stem Cells
579. p63 deficiency activates a program of cellular senescence and leads to accelerated aging
580. Weak p53 permits senescence during cell cycle arrest
581. Aging and sensory senescence.
582. Pathways connecting telomeres and p53 in senescence, apoptosis, and cancer
583. Tumour suppression by p53: the importance of apoptosis and cellular senescence
584. Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells
585. Does a Sentinel or a Subset of Short Telomeres Determine Replicative senescence?
586. Markers for hypersensitive response and senescence show distinct patterns of expression
587. The role of nuclear lamin B1 in cell proliferation and senescence
588. Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis
589. Post‐traumatic osteoarthritis: The role of accelerated chondrocyte senescence
590. senescence and the healing rates of venous ulcers
591. The senescence‐Related Mitochondrial/Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem Cells
592. senescence and Receptivity of Maize Silks
593. Molecular signature of oncogenic ras-induced senescence
594. senescence and Embedded-Figure Performance in Vision and Touch
595. Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells
596. Role of calcium in ripening and senescence
597. Pheophytin Pheophorbide Hydrolase (Pheophytinase) Is Involved in Chlorophyll Breakdown during Leaf senescence in Arabidopsis
598. Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence
599. Id-1 Delays senescence but Does Not Immortalize Keratinocytes
600. Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular senescence
601. Cellular aging and senescence
602. Mitochondrial production of pro-oxidants and cellular senescence
603. p16INK4a can initiate an autonomous senescence program
604. Genetic analysis of cellular senescence
605. A comparison of the expression patterns of several senescence-associated genes in response to stress and hormone treatment
606. Replicative senescence Revisited
607. Evolution of accelerated senescence in laboratory populations of Drosophila
608. Cytoplasmic chromatin triggers inflammation in senescence and cancer
609. Hormone-directed Transport of Metabolites and its possible Role in Plant senescence
610. The evolution of senescence in fish
611. senescence‐associated lncRNAs: senescence‐associated long noncoding RNAs
612. Regulation of Leaf senescence by Cytokinin, Sugars, and Light
613. Cellular senescence in the pathogenesis of benign prostatic hyperplasia
614. A causal link between respiration and senescence in Podospora anserina
615. Early Compositional Changes during Postharvest senescence of Broccoli
616. HDA6 is required for jasmonate response, senescence and flowering in Arabidopsis
617. Arabidopsis Cytokinin Receptor Mutants Reveal Functions in Shoot Growth, Leaf senescence, Seed Size, Germination, Root Development, and Cytokinin Metabolism
618. Leaf senescence and activities of the antioxidant enzymes
619. Cellular senescence drives age-dependent hepatic steatosis
620. Cloning and characterization of tomato leaf senescence-related cDNAs
621. Role of Telomerase in Cell senescence and Oncogenesis
622. Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands
623. senescence in fishes
624. Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways
625. CD28 extinction in human T cells: altered functions and the program of T‐cell senescence
626. Mitochondrial Dysfunction in the senescence Accelerated Mouse (SAM)
627. Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts
628. Adriamycin-induced senescence in Breast Tumor Cells Involves Functional p53 and Telomere Dysfunction
629. MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8
630. senescence in natural populations of animals: Widespread evidence and its implications for bio-gerontology
631. Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence.
632. The Control of Autumn senescence in European Aspen
633. Genetic regulation of primitive hematopoietic stem cell senescence
634. DNA fragmentation is regulated by ethylene during carpel senescence in Pisum sativum
635. AUXIN RESPONSE FACTOR1 and AUXIN RESPONSE FACTOR2 regulate senescence and floral organ abscission in Arabidopsis thaliana
636. p63–microRNA feedback in keratinocyte senescence
637. Role of the Ascorbate-Glutathione Cycle of Mitochondria and Peroxisomes in the senescence of Pea Leaves
638. Effects of PSAG12-IPT Gene Expression on Development and senescence in Transgenic Lettuce
639. Involvement of free radicals in ageing: a consequence or cause of senescence
640. The Remobilization of Nitrogen Related to Leaf Growth and senescence in Rice Plants (Oryza sativa L.)
641. NF-κB inhibition delays DNA damage–induced senescence and aging in mice
642. Decreased beta-adrenergic responsiveness during senescence.
643. Membrane phospholipid catabolism and Ca2+ activity in control of senescence
644. Mechanism of Monocarpic senescence in Rice
645. Oxidative stress occurs during soybean nodule senescence
646. Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence.
647. Longevity and the genetic determination of collagen glycoxidation kinetics in mammalian senescence
648. High levels of antioxidant enzymes correlate with delayed senescence in nonnetted muskmelon fruits
649. Relationship between Photosynthesis and Chlorophyll Content during Leaf senescence of Rice Seedlings
650. The Role of Ethylene in the senescence of Oat Leaves
651. Splicing into senescence: The Curious Case of p16 and p19ARF
652. The Gene Expression Program of Prostate Fibroblast senescence Modulates Neoplastic Epithelial Cell Proliferation through Paracrine Mechanisms
653. Cellular senescence and chromatin organisation
654. Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53
655. Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence
656. DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?
657. Ageing, telomeres, senescence, and liver injury
658. Evidence That Aging And Amyloid Promote Microglial Cell senescence
659. Cellular senescence and DNA repair
660. Rethinking the evolutionary theory of aging: Transfers, not births, shape senescence in social species
661. Vascular Smooth Muscle Cells Undergo Telomere-Based senescence in Human Atherosclerosis
662. Assessing Cell and Organ senescence Biomarkers
663. Molecular Regulation of Melanocyte senescence
664. Premature senescence of endothelial cells: Methusaleh’s dilemma
665. Resistance to Environmental Stress in Drosophila melanogaster Selected for Postponed senescence
666. Oxidative stress induces senescence in chondrocytes
667. p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence
668. HIF1α delays premature senescence through the activation of MIF
669. Retardation of leaf senescence by benzyladenine in intact bean plants
670. Cellular senescence and the aging brain
671. Carnosine as a Potential Anti-senescence Drug
672. The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15Ink4b
673. Cellular aging–clonal senescence. A review (Part I)
674. Is Accelerated senescence a Cost of Reproduction?
675. Astrocytes in the aging brain express characteristics of senescence‐associated secretory phenotype
676. MicroRNAs linking inflamm-aging, cellular senescence and cancer
677. senescence-associated inflammatory responses: aging and cancer perspectives
678. Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53‐dependent cellular senescence
679. Altered fruit ripening and leaf senescence in tomatoes expressing an antisense ethylene‐forming enzyme transgene
680. Antioxidants Inhibit Nuclear Export of Telomerase Reverse Transcriptase and Delay Replicative senescence of Endothelial Cells
681. The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4
682. Evidence that exposure of the telomere 3′ overhang sequence induces senescence
683. Physiological compensation for loss of afferent synapses in rat hippocampal granule cells during senescence.
684. Ribulose Bisphosphate Carboxylase and Proteolytic Activity in Wheat Leaves from Anthesis through senescence
685. Spontaneous age-associated amyloidosis in senescence-accelerated mouse (SAM)
686. Cellular senescence: Molecular Mechanisms, In Vivo Significance, and Redox Considerations
687. Overexpression of Arabidopsis Hexokinase in Tomato Plants Inhibits Growth, Reduces Photosynthesis, and Induces Rapid senescence
688. senescence induction; a possible cancer therapy
689. Cell senescence and Its Implications for Nephrology
690. Accelerated senescence: An emerging role in tumor cell response to chemotherapy and radiation
691. Central Role of the Proteasome in senescence and Survival of Human Fibroblasts
     INDUCTION OF A senescence-LIKE PHENOTYPE UPON ITS INHIBITION AND RESISTANCE TO STRESS UPON ITS ACTIVATION
692. Differential Roles for Cyclin-Dependent Kinase Inhibitors p21 and p16 in the Mechanisms of senescence and Differentiation in Human Fibroblasts
693. senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts.
694. Characteristics of age-related behavioral changes in senescence-accelerated mouse SAMP8 and SAMP10
695. Mammalian Prohibitin Proteins Respond to Mitochondrial Stress and Decrease during Cellular senescence
696. Antisense suppression of phospholipase D alpha retards abscisic acid- and ethylene-promoted senescence of postharvest Arabidopsis leaves.
697. Autophagy, senescence and tumor dormancy in cancer therapy
698. senescence of immune defence in Bombus workers
699. senescence-Induced Serotonin Biosynthesis and Its Role in Delaying senescence in Rice Leaves
700. Role of T lymphocyte replicative senescence in vaccine efficacy
701. Dental senescence in a long-lived primate links infant survival to rainfall
702. The influence of sward condition on rates of herbage growth and senescence in mixed swards under continuous stocking management
703. Cytokinin Activity in Rose Petals and Its Relation to senescence
704. Evidence for Multiple Pathways to Cellular senescence
705. Arabidopsis Nitric Oxide Synthase1 Is Targeted to Mitochondria and Protects against Oxidative Damage and Dark-Induced senescence
706. Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and senescence in Neuroblastoma
707. Cellular senescence in cancer treatment: friend or foe?
708. Human chondrocyte senescence and osteoarthritis
709. Spectral Reflectance Changes Associated with Autumn senescence of Aesculus hippocastanum L. and Acer platanoides L. Leaves. Spectral Features and Relation to Chlorophyll Estimation
710. BULB-TYPE FLOWER senescence
711. Pathway analysis of senescence-associated miRNA targets reveals common processes to different senescence induction mechanisms
712. Protein oxidation and degradation during postmitotic senescence
713. Doubling potential, calendar time, and senescence of human diploid cells in culture
714. Inflammatory bowel disease-like enteritis and caecitis in a senescence accelerated mouse P1/Yit strain
715. Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis
716. mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
717. senescence Is Induced in Individually Darkened Arabidopsis Leaves, but Inhibited in Whole Darkened Plants
718. Hypoxia suppresses conversion from proliferative arrest to cellular senescence
719. RNS2: a senescence-associated RNase of Arabidopsis that diverged from the S-RNases before speciation
720. Interleukin‐22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice
721. Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts
722. Evolutionary Biology of senescence
723. Eating to exit: autophagy-enabled senescence revealed
724. Loss of CD28 expression on T lymphocytes: A marker of replicative senescence
725. senescence‐associated vacuoles with intense proteolytic activity develop in leaves of Arabidopsis and soybean
726. senescence-associated beta-galactosidase histochemistry for the primate eye.
727. Cytokine loops driving senescence
728. MicroRegulators come of age in senescence
729. DNA end joining becomes less efficient and more error-prone during cellular senescence
730. Conditional senescence in bacteria: death of the immortals
731. senescence and Death of Primitive Cells and Myocytes Lead to Premature Cardiac Aging and Heart Failure
732. Isolation and analysis of cDNAs encoding tomato cysteine proteases expressed during leaf senescence
733. Negligible senescence in the longest living rodent, the naked mole-rat: insights from a successfully aging species
734. Mate Choice, Sexual Conflict, and Evolution of senescence
735. Markers of cellular senescence. Telomere shortening as a marker of cellular senescence
736. Stress-Induced Legume Root Nodule senescence. Physiological, Biochemical, and Structural Alterations
737. Chlorophyll b reduction during senescence of barley seedlings
738. Categories of Petal senescence and Abscission: A Re-evaluation
739. Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a senescence-like Arrest Mediated by p27Kip1
740. Relation between Nitrogen and Ribulose-1,5-bisphosphate Carboxylase in Rice Leaves from Emergence through senescence
741. ETHYLENE-INSENSITIVE3 Is a senescence-Associated Gene That Accelerates Age-Dependent Leaf senescence by Directly Repressing miR164 Transcription in Arabidopsis
742. TP53 and MTOR crosstalk to regulate cellular senescence
743. senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans
744. Physiological and pathological consequences of cellular senescence
745. Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts
746. senescence from G2 arrest, revisited
747. ORS1, an H2O2-Responsive NAC Transcription Factor, Controls senescence in Arabidopsis thaliana
748. THE KINETICS OF senescence
749. Arbuscular mycorrhizal symbiosis can alleviate drought‐induced nodule senescence in soybean plants
750. High-Resolution Temporal Profiling of Transcripts during Arabidopsis Leaf senescence Reveals a Distinct Chronology of Processes and Regulation
751. The evolution of senescence from a comparative perspective
752. Relationship between Ethylene Evolution and senescence in Morning-Glory Flower Tissue
753. WRKY22 transcription factor mediates dark-induced leaf senescence in Arabidopsis
754. senescence of nickel-transformed cells by an X chromosome: possible epigenetic control
755. Hydrogen sulfide acts as a regulator of flower senescence in plants
756. Gene expression during anthesis and senescence in Iris flowers
757. Induced senescence of Intact Wheat Seedlings and Its Reversibility
758. Oncogene-induced senescence: the bright and dark side of the response
759. miR-29 and miR-30 regulate B-Myb expression during cellular senescence
760. Negligible senescence during Reproductive Dormancy in Drosophila melanogaster
761. Delayed Leaf senescence in Tobacco Plants Transformed with tmr, a Gene for Cytokinin Production in Agrobacterium.
762. Monitoring Tumorigenesis and senescence In Vivo with a p16INK4a-Luciferase Model
763. Endothelial Cell senescence
764. Hormonal changes during salinity-induced leaf senescence in tomato (Solanum lycopersicum L.)
765. Short Periods of Water Stress during Seed Filling, Leaf senescence, and Yield of Soybean
766. senescence, nutrient remobilization, and yield in wheat and barley
767. senescence and the Genetic-Correlation Hang-Up
768. REVIEW ARTICLE. p53: GUARDIAN OF CELLULAR senescence
769. Phospholipase D in cellular senescence
770. Rice NON-YELLOW COLORING1 Is Involved in Light-Harvesting Complex II and Grana Degradation during Leaf senescence
771. Delayed leaf senescence in ethylene‐deficient ACC‐oxidase antisense tomato plants: molecular and physiological analysis
772. Source : sink ratio and leaf senescence in maize:: I. Dry matter accumulation and partitioning during grain filling
773. Carotenoid catabolism during leaf senescence and its control by light
774. senescence: does it all happen at the ends?
775. Oxidative stress induces senescence in human mesenchymal stem cells
776. DNA damage, vascular senescence and atherosclerosis
777. Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration
778. DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion
779. Role of p21 in Apoptosis and senescence of Human Colon Cancer Cells Treated with Camptothecin
780. Oxygen free radicals in cell senescence: Are they signal transducers?
781. Genetics of cellular senescence
782. Regulation of E2Fs and senescence by PML nuclear bodies
783. Cellular senescence and cancer chemotherapy resistance
784. RNA Interference of Human Papillomavirus Type 18 E6 and E7 Induces senescence in HeLa Cells
785. senescence and immortality in hepatocellular carcinoma
786. senescence Processes in Leaf Abscission
787. Acceleration of Membrane senescence in Cut Carnation Flowers by Treatment with Ethylene
788. Oncogenic functions of tumour suppressor p21Waf1/Cip1/Sdi1: association with cell senescence and tumour-promoting activities of stromal fibroblasts
789. WRKY54 and WRKY70 co-operate as negative regulators of leaf senescence in Arabidopsis thaliana
790. Calcium regulation of senescence in rose petals
791. Leaf senescence in Brassica napus: expression of genes encoding pathogenesis-related proteins
792. Leaf senescence in maize hybrids: plant population, row spacing and kernel set effects
793. The Effects of Ear Removal on senescence and Metabolism of Maize
794. Time, telomeres and tumours: is cellular senescence more than an anticancer mechanism?
795. Asexual metazoans undergo senescence.
796. The biochemistry and regulation of senescence in chloroplasts
797. Catalase and Peroxidase in Primary Bean Leavesduring Development and senescence
798. Correlation of Xylem Sap Cytokinin Levels with Monocarpic senescence in Soybean
799. Induction of senescence by oncogenic ras
800. Mechanisms of polyamine action during senescence responses induced by osmotic stress
801. Papillomavirus E2 induces senescence in HPV‐positive cells via pRB‐ and p21CIP‐dependent pathways
802. Role of Ethylene in the senescence of Detached Rice Leaves
803. senescence, Stress, and Reactive Oxygen Species
804. A Role for Glutamine Synthetase in the Remobilization of Leaf Nitrogen during Natural senescence in Rice Leaves
805. Predatory senescence in ageing wolves
806. Hydrogen Sulfide Protects Against Cellular senescence via S-Sulfhydration of Keap1 and Activation of Nrf2
807. Estrogen reduces endothelial progenitor cell senescence through augmentation of telomerase activity
808. ABA receptor PYL9 promotes drought resistance and leaf senescence
809. senescence-associated reprogramming promotes cancer stemness
810. Arabidopsis AtNAP regulates fruit senescence
811. Reversible senescence in Human CD4+CD45RA+CD27− Memory
812. T Cell Activation and senescence Predict Subclinical Carotid Artery Disease in HIV-Infected Women
813. Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition
814. Evolutionary mechanisms of senescence
815. Changes in Capsaicinoids during Development, Maturation, and senescence of Chile Peppers and Relation with Peroxidase Activity
816. The Vacuole and Cell senescence
817. The role of ubiquitin in plant senescence and stress responses
818. DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly
819. Induction of senescence in human malignant glioma cells by p16INK4A
820. Leaf peroxisomes are directly transformed to glyoxysomes during senescence of pumpkin cotyledons
821. Convergence and divergence in gene expression profiles induced by leaf senescence and 27 senescence‐promoting hormonal, pathological and environmental stress treatments
822. senescence mechanisms of nucleus pulposus chondrocytes in human intervertebral discs
823. Transcriptional regulation of cellular senescence
824. Molecular and Cell Biology of Replicative senescence
825. Ethylene-regulated expression of a carnation cysteine proteinase during flower petal senescence
826. senescence and death of plant organs: Nutrient recycling and developmental regulation
827. p16Ink4a overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors
828. Chemokines Acting via CXCR2 and CXCR4 Control the Release of Neutrophils from the Bone Marrow and Their Return following senescence
829. The senescence of the Immune System
830. Telomere-driven replicative senescence is a stress response
831. Methyl Jasmonate, Calcium, and Leaf senescence in Rice
832. Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras
833. Smurf2 up-regulation activates telomere-dependent senescence
834. Autophagy and senescence
835. Critical pathways in cellular senescence and immortalization revealed by gene expression profiling
836. The evolutionary ecology of pre- and post-meiotic sperm senescence
837. Inhibition of phospholipase D by lysophosphatidylethanolamine, a lipid-derived senescence retardant
838. Chlorophyll-a degradation during cellular senescence and death
839. Integrated Signaling in Flower senescence
840. Mechanisms of Disease: role of chondrocytes in the pathogenesis of osteoarthritis—structure, chaos and senescence
841. Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency
842. PML interaction with p53 and its role in apoptosis and replicative senescence
843. Thidiazuron—a potent inhibitor of leaf senescence in Alstroemeria
844. The disparity between human cell senescence in vitro and lifelong replication in vivo
845. Ethylene receptor expression is regulated during fruit ripening, flower senescence and abscission
846. T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infection
847. Expression of Caveolin-1 Induces Premature Cellular senescence in Primary Cultures of Murine Fibroblasts
848. A Systematic Screen for CDK4/6 Substrates Links FOXM1 Phosphorylation to senescence Suppression in Cancer Cells
849. Stress-induced premature senescence and replicative senescence are different phenotypes, proteomic evidence
850. Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)
851. Endogenous Human Papillomavirus E6 and E7 Proteins Differentially Regulate Proliferation, senescence, and Apoptosis in HeLa Cervical Carcinoma Cells
852. Transcriptome analysis of senescence in the flag leaf of wheat (Triticum aestivum L.)
853. Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-κB
854. The Relation of Autoǵamy to senescence and Rejuvenescence in Paramecium aurelia
855. senescence and Genetic Load: Evidence from Tribolium
856. senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform
857. Leaf senescence – not just a ‘wear and tear’ phenomenon
858. Immune senescence: Mechanisms and Clinical Implications
859. Involvement of the INK4a/Arf gene locus in senescence
860. Free radical oxidation of brain proteins in accelerated senescence and its modulation by N-tert-butyl-α-phenylnitrone
861. ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence
862. Errors in Protein Synthesis and Clonal senescence in Fungi
863. The E3 SUMO Ligase PIASy Is a Regulator of Cellular senescence and Apoptosis
864. miRNA-205 Suppresses Melanoma Cell Proliferation and Induces senescence via Regulation of E2F1 Protein
865. Hidden costs of infection: Chronic malaria accelerates telomere degradation and senescence in wild birds
866. Replicative senescence of CD8 T cells: effect on human ageing
867. Studies on Soybean Nodule senescence
868. Cellular senescence: Its role in tumor suppression and aging
869. Evidence for the function of the free radical gas — nitric oxide (NO•) — as an endogenous maturation and senescence regulating factor in higher plants
870. AtATG18a is required for the formation of autophagosomes during nutrient stress and senescence in Arabidopsis thaliana
871. Propagation and senescence of human marrow stromal cells in culture: a simple colony‐forming assay identifies samples with the greatest potential to propagate and differentiate
872. senescence Regulation by the p53 Protein Family
873. Cell surface-bound IL-1α is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network
874. mTOR Inhibition Prevents Epithelial Stem Cell senescence and Protects from Radiation-Induced Mucositis
875. Cellular lifespan and senescence signaling in embryonic stem cells
876. Lung fibroblasts from patients with emphysema show markers of senescence in vitro
877. Future atmospheric CO2 leads to delayed autumnal senescence
878. Sugars, senescence, and ageing in plants and heterotrophic organisms
879. Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation
880. Mutation and senescence: where genetics and demography meet
881. miR-200c is upregulated by oxidative stress and induces endothelial cell apoptosis and senescence via ZEB1 inhibition
882. ATR signaling can drive cells into senescence in the absence of DNA breaks
883. OPTIMALITY THEORY, GOMPERTZ’ LAW, AND THE DISPOSABLE SOMA THEORY OF senescence
884. Inhibition of ethylene synthesis and senescence in carnation by ethanol.
885. In vitro simulation of senescence-related membrane damage by ozone-induced lipid peroxidation
886. Telomere-dependent senescence
887. Stress-induced senescence in human and rodent astrocytes
888. The evolutionary basis of leaf senescence: Method to the madness?
889. Leaf Proteolytic Activities and senescence during Grain Development of Field-grown Corn (Zea mays L.)
890. Hypoxia, MTOR and autophagy
     Converging on senescence or quiescence
891. Long‐term exogenous application of melatonin delays drought‐induced leaf senescence in apple
892. Integration of soybean pod development and monocarpic senescence
893. Tissue damage and senescence provide critical signals for cellular reprogramming in vivo
894. Unexpected Pieces to the senescence Puzzle
895. Cell senescence: Role in Aging and Age-Related Diseases
896. Disposable-soma senescence mediated by sexual selection in an ungulate
897. Reactive oxygen species and hematopoietic stem cell senescence
898. Biochemical changes related to aging in the senescence-accelerated mouse
899. Programmed senescence of plant organs
900. SOCS1 Links Cytokine Signaling to p53 and senescence
901. The role of ascorbic acid in the control of flowering time and the onset of senescence
902. Autophagy and senescence in Cancer Therapy
903. Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer
904. Aging in Legume Symbiosis. A Molecular View on Nodule senescence in Medicago truncatula
905. A gene regulatory network controlled by the NAC transcription factor ANAC092/AtNAC2/ORE1 during salt‐promoted senescence
906. DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence
907. Evidence of cell loss from the rat retina during senescence
908. Evidence for a senescence-Associated Gene Induced by Darkness
909. Ascorbic acid, a familiar small molecule intertwined in the response of plants to ozone, pathogens, and the onset of senescence
910. Targeting cellular senescence prevents age-related bone loss in mice
911. Executing Cell senescence
912. Aging and senescence in plant developent.
913. Cortical bone senescence and mineral bone density of the humerus
914. Control of cellular senescence by CPEB
915. Morphological and contractile characteristics of rat cardiac myocytes from maturation to senescence
916. p16/pRb Pathway Alterations Are Required for Bypassing senescence in Human Prostate Epithelial Cells
917. Vemurafenib Induces senescence Features in Melanoma Cells
918. Role of growth regulators in the senescence of Arabidopsis thaliana leaves
919. Pigment dynamics and autumn leaf senescence in a New England deciduous forest, eastern USA
920. Suppression of tumor growth by senescence in virally transformed human fibroblasts
921. Factors that accelerate or retard red blood cell senescence.
922. IndependentInductionofsenescencebyp16INK4
923. Multiple pathways to cellular senescence: Role of telomerase repressors
924. Octopus senescence: The Beginning of the End
925. A new member of the Arabidopsis WRKY transcription factor family, AtWRKY6, is associated with both senescence‐ and defence‐related processes
926. Demographic Perspectives on Human senescence
927. Molecular mechanisms of replicative senescence in endothelial cells
928. Does Maintaining Green Leaf Area in Sorghum Improve Yield under Drought? I. Leaf Growth and senescence
929. Functional Aging and Gradual senescence in Zebrafish
930. A reassessment of the telomere hypothesis of senescence
931. Interrelationships of Ethylene and Abscisic Acid in the Control of Rose Petal senescence
932. Promotive Effect of Methyl Jasmonate on Oat Leaf senescence in the Light
933. senescence in podospora anserina: Amplification of a mitochondrial DNA sequence
934. Evolution of senescence in iteroparous perennial plants
935. Comparison of replicative senescence and stress‐induced premature senescence combining differential display and low‐density DNA arrays
936. POLLINATION-INDUCED COROLLA senescence
937. The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A–ARF locus in response to oncogene- and stress-induced senescence
938. Legume nodule senescence: roles for redox and hormone signalling in the orchestration of the natural aging process
939. Mitochondrial-Targeted Plastoquinone Derivatives. Effect on senescence and Acute Age-Related Pathologies
940. Dark‐inducible genes from Arabidopsisthaliana are associated with leaf senescence and repressed by sugars
941. Nitric oxide counteracts the senescence of rice leaves induced by abscisic acid
942. Cellular senescence in Type 2 Diabetes: A Therapeutic Opportunity
943. senescence of the retinal pigment epithelium
944. senescence-related serine protease in parsley
945. The Metabolism of Oat Leaves during senescence
946. Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence.
947. Markers of senescence?
948. Repair of telomeric DNA prior to replicative senescence
949. Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney
950. Regulation of detached coriander leaf senescence by 1-methylcyclopropene and ethylene
951. Stress-Activated MAP Kinase Cascades in Cellular senescence
952. Cellular senescence in Vitro
953. Inhibition of ethylene‐induced cellular senescence symptoms by 1‐methylcyclopropene, a new inhibitor of ethylene action
954. The Complex Regulation of senescence
955. Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence
956. Delayed senescence of apple leaves by exogenous melatonin treatment: toward regulating the ascorbate–glutathione cycle
957. High Levels of Brain Dolichols in Neuronal Ceroid‐Lipofuscinosis and senescence
958. An anti-aging drug today: from senescence-promoting genes to anti-aging pill
959. Homocysteine accelerates senescence and reduces proliferation of endothelial progenitor cells
960. Posttranslational Modifications of p53 in Replicative senescence Overlapping but Distinct from Those Induced by DNA Damage
961. Aging, life span, and senescence
962. The Role of Arabidopsis Rubisco Activase in Jasmonate-Induced Leaf senescence
963. Connecting autophagy to senescence in pathophysiology
964. Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts
965. miR-335 and miR-34a Promote Renal senescence by Suppressing Mitochondrial Antioxidative Enzymes
966. senescence-Accelerated Mouse (SAM) with Special References to Neurodegeneration Models, SAMP8 and SAMP10 Mice
967. Glycated Collagen I Induces Premature senescence-Like Phenotypic Changes in Endothelial Cells
968. Image analysis of GFA-positive astrocytes from adolescence to senescence
969. Escape from Therapy-Induced Accelerated Cellular senescence in p53-Null Lung Cancer Cells and in Human Lung Cancers
970. Cloning of senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen
971. Localization of senescent cell antigen on band 3
972. A senescent cell bystander effect: senescence‐induced senescence
973. senescent cell antigen is immunologically related to band 3
974. Measurement of DNA content and cell volume in senescent human fibroblasts utilizing flow multiparameter single cell analysis
975. A New LIM Protein Containing an Autoepitope Homologous to “senescent Cell Antigen”
976. Generation of senescent cell antigen on old cells initiates IgG binding to a neoantigen.
977. Mimetics of senescent cell derived inhibitors of DNA synthesis
978. senescent Keratinocytes Die by Autophagic Programmed Cell Death
979. Rapid disappearance of statin, a nonproliferating and senescent cell-specific protein, upon reentering the process
980. Molecular Mechanisms for the senescent Cell Cycle Arrest
981. Membrane Fragmentation and Ca++-Membrane Interaction : Potential Mechanisms of Shape Change in the senescent Red Cell
982. Long-Term in vitro Growth of Human T Cell Clones: Can Postmitotic ‘senescent’ Cell Populations Be Defined?
983. senescent cell derived inhibitors of DNA synthesis
984. Antigenicity, storage, and aging: physiologic autoantibodies to cell membrane and serum proteins and the senescent cell antigen
985. Aging of Cell Membrane Molecules Leads to Appearance of an Aging Antigen and Removal of senescent cells
986. Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice
987. Inhibition of intimal hyperplasia after vein grafting by in vivo transfer of human senescent cell-derived inhibitor-1 gene
988. Identification of senescent cell surface targetable protein DPP4
989. Synthetic senescent cell antigen
990. senescent vs. non-senescent cells in the human annulus in vivo: Cell harvest with laser capture microdissection and gene expression studies with microarray analysis
991. senescent cell derived inhibitors of DNA synthesis
992. Glucose transport protein is structurally and immunologically related to band 3 and senescent cell antigen
993. senescent Human Fibroblasts Resist Programmed Cell Death, and Failure to Suppress bcl2 Is Involved
994. Duration of senescent cell survival in vitro as a characteristic of organism longevity, an additional to the proliferative potential of fibroblasts
995. Antibodies to senescent cell-derived inhibiters of DNA synthesis
996. Expression of cell cycle-dependent genes in young and senescent WI-38 fibroblasts
997. Induction of senescent cell-derived inhibitor of DNA synthesis gene, SDI1, in hepatoblastoma (HepG2) cells arrested in the G2-phase of the cell cycle by 9-nitrocamptothecin.
998. Relationship between cell replication and volume in senescent human diploid fibroblasts
999. p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling
1000. Cell-Cell Affinity of senescent Human Erythrocytes
1001. The Ability to Generate senescent Progeny as a Mechanism Underlying Breast Cancer Cell Heterogeneity
1002. senescent and quiescent cell inhibitors of DNA synthesis: Membrane-associated proteins
1003. Pseudomonas aeruginosa Transmigrates at Epithelial Cell-Cell Junctions, Exploiting Sites of Cell Division and senescent Cell Extrusion
1004. senescent cell antigen, band 3, and band 3 mutations in cellular aging.
1005. SCAMP4 enhances the senescent cell secretome
1006. senescent cell differentiation antigen.
1007. Reinitiation of DNA Synthesis and Cell Division in senescent Human Fibroblasts by Microinjection of Anti-p53 Antibodies
1008. Aging of cell membrane molecules: Band 3 and senescent cell antigen in neural tissue
1009. Impaired Cell Shortening and Relengthening with Increased Pacing Frequency are Intrinsic to the senescent Mouse Cardiomyocyte
1010. Dynamics of senescent Cell Formation and Retention Revealed by p14ARF Induction in the Epidermis
1011. Entry into S phase is inhibited in two immortal cell lines fused to senescent human diploid cells
1012. senescent cell death brings hopes to life
1013. Common senescent cell‐specific antibody epitopes on fibronectin in species and cells of varied origin
1014. senescent cell derived inhibitors of DNA synthesis
1015. Restoration of the responsiveness to growth factors in senescent cells by an embryonic cell extract
1016. MnSOD Upregulation Induces Autophagic Programmed Cell Death in senescent Keratinocytes
1017. Spontaneous cell transformation: Karyoplasts derived from multinucleated cells produce new cell growth in senescent human epithelial cell cultures
1018. senescent cell antigen: a terminal differentiation antigen.
1019. Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2
1020. Fibroblasts derived from Gpx1 knockout mice display senescent-like features and are susceptible to H2O2-mediated cell death
1021. Molecular Mapping of the Active Site of an Aging Antigen: senescent Cell Antigen Requires Lysine(s) for Antigenicity and Is Located on an Anion-Binding Segment of Band 3 Membrane Transport Protein
1022. Human platelet lysate stimulates high-passage and senescent human multipotent mesenchymal stromal cell growth and rejuvenation in vitro
1023. Gerontology and drug development: The challenge of the senescent cell
1024. Chlorophyll Degradation in senescent Tobacco Cell Culture (Nicotiana tabacum var. «Samsun»)
1025. Down-regulation of Akt/PKB in senescent cardiac fibroblasts impairs PDGF-induced cell proliferation
1026. Type 1 interferons contribute to the clearance of senescent cell
1027. Robust nuclear lamina-based cell classification of aging and senescent cells
1028. Simvastatin suppresses breast cancer cell proliferation induced by senescent cells
1029. Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype
1030. Appearance of the terminal senescent cell population in human diploid fibroblasts analyzed by flow cytometry
1031. Some chemotherapeutics-treated colon cancer cells display a specific phenotype being a combination of stem-like and senescent cell features
1032. mRNA levels of the differentiation-associated linker histone variant H1 zero in mitotically active and postmitotic senescent human diploid fibroblast cell populations
1033. Method To Purify and Analyze Heterogeneous senescent Cell Populations Using a Microfluidic Filter with Uniform Fluidic Profile
1034. Mapping of senescent cell antigen on brain anion exchanger protein (AE) isoforms using HPLC and fast atom bombardment ionization mass spectrometry (FAB‐MS)
1035. Evaluation of a near‐senescent human dermal fibroblast cell line and effect of amelogenin
1036. Level of macroautophagy drives senescent keratinocytes into cell death or neoplastic evasion
1037. Genes and ageing: beyond good and evil in the senescent cell
1038. Method of optimizing conditions for selectively removing a plurality of senescent cells from a tissue or a mixed cell population
1039. Complementation between senescent human diploid cells and a thymidine kinase-deficient murine cell line
1040. Targeting senescent cholangiocytes and activated fibroblasts with B‐cell lymphoma‐extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/−) mice
1041. Diet-induced weight loss is sufficient to reduce senescent cell number in white adipose tissue of weight-cycled mice
1042. Natural killer cell recognition of in vivo drug-induced senescent multiple myeloma cells
1043. senescence-associated secretory factors induced by cisplatin in melanoma cells promote non-senescent melanoma cell growth through activation of the ERK1/2-RSK1 pathway
1044. Density-gradient centrifugation enables the purification of cultured corneal endothelial cells for cell therapy by eliminating senescent cells
1045. senescent cell clearance by the immune system: Emerging therapeutic opportunities
1046. Life and Death of Neurons: The Role of senescent Cell Antigen
1047. Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability
1048. Retroviral vectors carrying senescent cell derived inhibitors 1 (SDI-1)or antisense SDI-1 nucleotide sequences
1049. In Vitro Expansion of Human Nasoseptal Chondrocytes Reveals Distinct Expression Profiles of G1 Cell Cycle Inhibitors for Replicative, Quiescent, and senescent Culture Stages
1050. Drug-Induced senescent Multiple Myeloma Cells Elicit NK Cell Proliferation by Direct or Exosome-Mediated IL15 Trans-Presentation
1051. Radiation-Induced Reprogramming of Pre-senescent Mammary Epithelial Cells Enriches Putative CD44+/CD24−/low Stem Cell Phenotype
1052. Epigallocatechin gallate suppresses premature senescence of preadipocytes by inhibition of PI3K/Akt/mTOR pathway and induces senescent cell death by regulation of Bax/Bcl-2 pathway
1053. The senescent cell epigenome
1054. CHAPTER 24 – senescent cell antigen and band 3 in aging and disease
1055. The mTORC1-autophagy pathway is a target for senescent cell elimination
1056. HPV-16 virions can remain infectious for 2 weeks on senescent cells but require cell cycle re-activation to allow virus entry
1057. Embryonic senescent cells re-enter cell cycle and contribute to tissues after birth
1058. Proteomics Analysis of Normal and senescent NG108-15 Cells: GRP78 Plays a Negative Role in Cisplatin-Induced senescence in the NG108-15 Cell Line
1059. Cell surface oligosaccharide modulation during differentiation: VI. The effect of biomodulation on the senescent and neoplastic cell phenotype
1060. Induction of Neointimal Formation by Local Gene Transfer of the Antisense senescent Cell-derived Inhibitor 1 (SDI) Delivered With the Needle Injection Catheter
1061. Antibody Dependent Cell Mediated Cytotoxicity and Phagocytosis of senescent Erythrocytes by Autologous Peripheral Blood Mononuclear Cells
1062. Phase-space description of the cell cycle: Application to noncycling, senescent, and transformed cells
1063. Effect of Overproduction of Mitochondrial Uncoupling Protein 2 on Cos7 Cells: Induction of senescent-like Morphology and Oncotic Cell Death
1064. senescent dermal fibroblasts enhance stem cell migration through CCL2/CCR2 axis
1065. Red cell aging: senescent cell antigen, band 3, and band 3 mutations associated with cellular dysfunction.
1066. Rock Inhibition Reduces senescent Cell Size
1067. The senescent Cell, SC
1068. senescent Cell Biomarkers
1069. THE senescent CELL POPULATION WITHIN NEW BONE PRODUCED BY DISTRACTION OSTEOGENESIS
1070. Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques
1071. Single senescent cell sequencing reveals heterogeneity in senescent cells induced by telomere erosion
1072. [Establishment of senescent cell model in primary rat aortic endothelial cells].
1073. THE ROLE OF THE RETINOBLASTOMA PROTEIN IN senescent CELL CYCLE EXIT, SURVIVAL, AND MORPHOLOGICAL ALTERATION
1074. Abstract 453: senescent Cell Depletion via Abt263 Augments Experimental Aortic Aneurysm Progression
1075. Aging and cancer: Cell non-autonomous effects of senescent fibroblasts on tissue microenvironment
1076. The senescent cell induced bystander effect
1077. [senescent cell antigens in the clearance of senescent cells].
1078. Material-induced senescence (MIS): Fluidity Induces senescent Type Cell Death of Lung Cancer Cells via Insulin-Like Growth Factor Binding Protein 5
1079. Abstract 361: Effects of Chronic, Intermittent senescent Cell Clearance in Combination with Lipid Lowering on Inflammation in Perivascular Adipose Tissue
1080. Active, Dormant, or on the Path to Elimination: What Does a senescent Cell Do?
1081. The connection between the cardiac glycoside‐induced senescent cell morphology and Rho/Rho kinase pathway
1082. Cloning of animals from senescent cell nuclei–what are the implications for aging research?
1083. Cell Cycle Traverse and Growth Arrest Control in senescent Human Fibroblasts
1084. senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition
1085. Aging and cancer: Cell non-autonomous effects of senescent fibroblasts on tissue microenvironment
1086. Klotho‐mediated targeting of CCL2 suppresses the induction of colorectal cancer progression by stromal cell senescent microenvironments
1087. Hydroxyurea‐induced senescent peripheral blood mesenchymal stromal cells inhibit bystander cell proliferation of JAK2V617F‐positive human erythroleukemia cells
1088. Aging and cancer: Cell non-autonomous effects of senescent fibroblasts on tissue microenvironment
1089. Antibodies to senescent Antigen and C3 Are Not Required for Normal Red Blood Cell Lifespan in a Murine Model
1090. Removing senescent cells from a mixed cell population or tissue using a phosphoinositide 3-kinase (pi3k) inhibitor
1091. Differential Regulation of Methylation-Regulating Enzymes by senescent Stromal Cells Drives Colorectal Cancer Cell Response to DNA-Demethylating Epi-Drugs
1092. senescent Pulmonary-Artery Smooth Muscle Cell (PA-SMC)-Derived Osteopontin Promotes PA-SMC Proliferation in Chronic Obstructive Pulmonary Disease
1093. 303: A role for senescent cell-derived IL6 in HER2+ breast cancer progression
1094. A New LIM Protein Containing an Autoepitope Homologous to ‘senescent Cell Antigen,’
1095. Aging and the senescent cell
1096. Differences between cytotoxicity of chemicals determined in vitro on young and old cells of a senescent cell line
1097. Modulation of Phenotype and Induction of Apoptosis in Vascular Smooth Muscle Cells (VSMC) by Transfer of Human senescent Cell-Derived Inhibitor-1 Gene: 190
1098. Adventitial gene transfer of the antisense to senescent cell-derived inhibitor 1 results in increased neointima
1099. senescent CELL DERIVED INHIBITORS OF DNA SYNTHESIS
1100. Cell cycle and apoptosis: death of a senescent cell
1101. MIMETICS OF senescent CELL DERIVED INHIBITORS OF DNA SYNTHESIS
1102. senescent cell distribution in human skeletal muscle : Role of exercise and protein availability
1103. A new LIM protein containing an autoepitope homologous to’senescent cell antigen’ (vol 201, pg 1127, 1994)
1104. Chemotherapeutics-treated cancer cells display stem-like and senescent cell features
1105. Fisetin is a senotherapeutic that extends health and lifespan
1106. The emerging field of senotherapeutic drugs
1107. SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs.
1108. Src Tyrosine Kinase Inhibitors: New Perspectives on Their Immune, Antiviral, and Senotherapeutic Potential
1109. Senotherapy: growing old and staying young?
1110. Senotherapy for attenuation of cellular senescence in aging and organ implantation
1111. Targeting normal and cancer senescent cells as a strategy of senotherapy
1112. Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)
1113. SASP reflects senescence
1114. SASP mediates chemoresistance and tumor-initiating-activity of mesothelioma cells
1115. Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses
1116. Detection of the senescence-associated secretory phenotype (SASP)
1117. Melatonin regulates PARP 1 to control the senescence‐associated secretory phenotype (SASP) in human fetal lung fibroblast cells
1118. Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2
1119. SASP: tumor suppressor or promoter? Yes!
1120. The experimental demonstration of a SASP-based full software radio receiver
1121. Anti-TNF-α treatment modulates SASP and SASP-related microRNAs in endothelial cells and in circulating angiogenic cells
1122. Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans
1123. Evaluation of the mutagenicity of the anti-inflammatory drug salicylazosulfapyridine (SASP)
1124. Whole Chromosome Instability induces senescence and promotes SASP
1125. SASP gene delivery: a novel antibacterial approach
1126. Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells
1127. The small acid soluble proteins (SASP α and SASP β) of Bacillus weihenstephanensis and Bacillus mycoides group 2 are the most distinct among the Bacillus cereus …
1128. ATM, MacroH2A. 1, and SASP: the checks and balances of cellular senescence
1129. … absorption of 5-aminosalicylic acid (5-ASA) after administration of a 5-ASA enema and salazosulfapyridine (SASP) after an SASP suppository in Japanese volunteers
1130. SASP (Small, Acid-Soluble Spore Proteins) and Spore Properties in Bacillus thuringiensis israelensis and Bacillus sphaericus
1131. Isolation and identification of Lom-SG-SASP, a salivation stimulating peptide from the salivary glands of Locusta migratoria
1132. Targeting the SASP to combat ageing: Mitochondria as possible intracellular allies?
1133. “Social Life” of Senescent Cells: What Is SASP and Why Study It?
1134. Synthesis and characterization of a 29-amino acid residue DNA-binding peptide derived from α/β-type small, acid-soluble spore proteins (SASP) of bacteria
1135. Effects of NAT2 polymorphism on SASP pharmacokinetics in Chinese population
1136. Sensitive detection and monitoring of senescence-associated secretory phenotype by SASP-RAP assay
1137. Another classic of EU sports jurisprudence: Legal implications of Olympique Lyonnais SASP v Olivier Bernard and Newcastle UFC (C-325/08)
1138. Clinical Observation on 30 Cases of Ulcerative Colitis of Damp Heat in the Large Intestine Stagnation Type Treated with Kuijieling Granules Combinated SASP [J]
1139. SASP regulation by noncoding RNA
1140. Scavenger effect of sulphasalazine (SASP), 5-aminosalicylic acid (5-ASA), and olsalazine (OAZ)
1141. SASP, a Senescence-Associated Subtilisin Protease, is involved in reproductive development and determination of silique number in Arabidopsis
1142. Symbol manipulation in FORTRAN: SASP I subroutines
1143. Chronic resveratrol treatment inhibits MRC5 fibroblast SASP-related protumoral effects on melanoma cells
1144. Pharmacokinetics of salazosulfapyridine (Sulfasalazine, SASP)(I): Plasma kinetics and plasma metabolites in the rat after a single intravenous or oral administration
1145. Sirt1 and Parp1 as epigenome safeguards and microRNAs as SASP-associated signals, in cellular senescence and aging
1146. SASP, a Production Planning and Control System for Shipbuilding on Individual Orders
1147. TORn about SASP regulation
1148. Case C-325/08, Olympique Lyonnais SASP v. Olivier Bernard and Newcastle United UFC, Judgment of the Court of Justice (Grand Chamber) of 16 March 2010
1149. Beneficial effect of salazosulfapyridine (SASP) in a patient with secondary renal amyloidosis
1150. Optical design and performance of the SASP spectrometer at TRIUMF
1151. Detecting the senescence-associated secretory phenotype (SASP) by high content microscopy analysis
1152. Pharmacokinetics of Salazosulfapyridine (Sulfasalazine, SASP)(V): Pharmacokinetics of SASP after a single intravenous or oral administration in the dog.
1153. Comparison of SKP (semi-automated kinetic perimetry) and SASP (suprathreshold automated static perimetry) techniques in patients with advanced glaucoma
1154. SIN3B, the SASP, and pancreatic cancer
1155. Pharmacokinetics of Salazosulfapyridine (Sulfasalazine, SASP)(III) Metabolism and biliary excretion of SASP in the rat after a single intravenous or oral administration.
1156. PAI-1 Regulation of TGF-β1-induced ATII Cell Senescence, SASP Secretion, and SASP-mediated Activation of Alveolar Macrophages
1157. Maintenance treatment of ulcerative colitis (UC) with oral 5-aminosalicylic acid (5-ASA) in patients unable to take sulphasalazine (SASP)
1158. Observation of curative effect of Sanguis Draxonis combined with SASP in the treatment of non-specific ulcerative colitis
1159. Replica exchange molecular dynamics simulations of an α/β-type small acid soluble protein (SASP)
1160. 98: Term fetal membranes and senescence associated secretory phenotype (SASP)-like gene expression: a signal for parturition?
1161. COMPARATIVE STUDY OF THE EFFECT OF SULPHASALAZINE (SASP) AND 3 5 DIPS ON GLUTATHIONE (GSH) LEVEL IN RED CELLS OF HUMAN BLOOD IN …
1162. Inhibition of neutral proteases from polymorphonuclear (PMN) neutrophils by salicylazosulfapyridine (SASP)
1163. Senescence-associated secretory phenotype (SASP) involvement in the development of cancer, aging, and age related diseases
1164. RNA-binding Protein Immunoprecipitation (RIP) to examine AUF1 binding to senescence-associated secretory phenotype (SASP) factor mRNA
1165. Modified bacteriophage including an alpha/beta small acid-soluble spore protein (SASP) gene
1166. Modified bacteriophage including an alpha/beta small acid-soluble spore protein (SASP) gene
1167. Arabidopsis subtilase SASP is involved in the regulation of ABA signaling and drought tolerance by interacting with OPEN STOMATA 1
1168. The first experimental demonstration of a SASP-based full Software Radio receiver
1169. A low power digitally-enhanced SASP-based receiver architecture for mobile DVB-S applications in the Ku-band (10.7–12.75 GHz)
1170. Senescence can be BETter without the SASP?
1171. Cancer cell cannibalism and the SASP: Ripples in the murky waters of tumor dormancy
1172. Methyl caffeate and some plant constituents inhibit age-related inflammation: effects on senescence-associated secretory phenotype (SASP) formation
1173. Dissecting cellular senescence and SASP in Drosophila
1174. 169: IL-19, a novel SASP factor, is upregulated during senescence and in response to DSBs
1175. Growth arrest by sulfasalazine (SASP) of subrenal capsule prostate cancer xenografts in immuno-deficient mice is coupled to a decrease in the number of tumor …
1176. COMPARISON OF THE EFFICACY OF 5 ASA AND SASP IN TREATMENT OF ULCERATIVE COLITIS
1177. A La Recherche of Functions for the Spore Protein SASP-E from Bacillus subtilis
1178. SASP: a symbolic algorithm for shortest paths
1179. Molecules and Clusters in Motion: Looking Back and Looking Forward, SASP and Beyond
1180. I no longer dread teaching physics, I now enjoy it!’Participant reflections from the SASP physics course
1181. The salivary gland salivation stimulating peptide from Locusta migratoria (Lom-SG-SASP) is not a typical neuropeptide
1182. Pharmacokinetics of Salazosulfapyridine (Sulfasalazine, SASP)(II) Tissue distribution and excretion of SASP in the rat after a single intravenous or oral administration.
1183. Deciphering the mechanism for induction of senescence-associated secretory phenotype (SASP) and its role in ageing and cancer development
1184. Optimisation of a screening platform for determining IL-6 inflammatory signalling in the senescence-associated secretory phenotype (SASP)
1185. Overexpression of Klotho Inhibits HELF Fibroblasts SASP-related Protumoral Effects on Non-small Cell Lung Cancer Cells
1186. SASP-Dependent Interactions between Senescent Cells and Platelets Modulate Migration and Invasion of Cancer Cells
1187. SKYNET Applications Software Package (SASP) Operators’ and Users’ Handbook, Version 2.
1188. The rehabilitation village-Paper presented at SASP Congress 1993
1189. Designing in uncertainty: The I-SASP model for tactical and innovative risk management in the hi-performing professional practice
1190. Characterization of structural changes in alpha/beta-type small, acid-soluble spore proteins (SASP) upon binding to DNA.
1191. SASP: The future of School Psychology
1192. Regulation of the senescence-associated secretory phenotype (SASP)
1193. Micromanaging fibroblast senescence: The role of small non-coding RNAs in senescence associated secretory phenotype (SASP)
1194. Effect of sulfasalazine (SASP) on sodium flux in rat colon
1195. Senescence utilises inflammatory caspases to drive SASP
1196. Outcome of Patients with Ankylosing Spondyloarthritis Continuing Treated with Thalidomide and SASP after a Short Course of Etanercept Therapy [J]
1197. Study on Effect of Regulation to Th1/Th2 in AUC Patients with Chinese Medicine Combined with SASP Enema under Guidance of Synchronous Treatment of Lung …
1198. Effect of combine probiotics with SASP on inflammatory bowel disease
1199. Changes of T regulatory cells in rats with experimental colitis after drug treatment with SASP and PSL
1200. Clinical effects of 99Tc-2MDP combined with SASP for ankylosing spondylitis
1201. Ex-SASP-erating cancer
1202. ETDEWEB/Search Results/Proceedings of the DASS/SASP (Dual Arm Spectrometer System/Second Arm Spectrometer) workshop
1203. Immunological Responses and Protection in Dairy Cows Vaccinated with Staphylococcus aureus Surface Proteins (SASP) and Staphylococcus chromogenes …
1204. Studies on the Role of SASP in Heat and Radiation Resistance of Bacterial Spores and on Regulation of a SASP Specific Protease
1205. Scavenger effect of sulphasalazine (SASP)
1206. SASP: targeted delivery to Gram-negative pathogens
1207. Slow-Release 5-Aminosalicylic Acid (Pentasa) versus Sulphasalazine (SASP) in the Maintenance Treatment of Ulcerative Colitis (82)
1208. SKYNET Applications Software Package (SASP) Programmers’ Handbook, Version 2.
1209. Signatures analysis systems prototype (SASP)
1210. PAI-1-Stimulated AT2 Cell SASP Promotes Profibrotic Polarization of Alveolar Macrophages
1211. … serum antibodies to bacterial antigens may be used as markers for the likelihood of response to SASP could have implications regarding the tailoring of SASP …
1212. Advances in pain management and research presented at the 2015 Scientific Meeting of the Scandinavian Association for the Study of Pain (SASP)
1213. SASP-A digital signal processor system for speech processing applications
1214. Poster-abstracts from SASP–The Scandinavian Association for the Study of Pain scientific meeting, Oslo, Norway, April 7–9, 2014
1215. The salivary gland salivation stimulating peptide from Locusta migratoria (Lom-SG-SASP) is not a neuropeptide
1216. Poor attendance at the SASP annual meeting
1217. … OF SOLUBLE TAU AGGREGATES IN BRAIN MICROVASCULAR ENDOTHELIAL CELLS PROMOTES CELLULAR SENESCENCE/SASP AND BLOCKS ENOS …
1218. Senescence-Associated Secretory Pheno-type (SASP)
1219. Provisional programme for SASP congress
1220. THE MANIPULATIVE THERAPISTS’GROUP OF THE SASP
1221. Algorithms for arithmetic operation in a systolic array of single-bit processor (SASP)
1222. SASP Erwin Schrödinger Gold Medal 2010
1223. Lipid metabolism is involved in mitotic slippage-induced SASP upon treatment with anti-mitotic drugs
1224. The role of SASP in tumor microenvironment.
1225. Effection of Tripterygium Wilfordii Unions SASP Moves to Rheumatoid Arthritis [J]
1226. Prospects for (p, pi) physics in the Delta region using the SASP spectrometer
1227. Scientific presentations at the 2017 annual meeting of the Scandinavian Association for the Study of Pain (SASP)
1228. Assessing Functional Roles of the Senescence-Associated Secretory Phenotype (SASP)
1229. Report of first AGM of obstetric group of SASP
1230. Conceptual design study Science and Application Space Platform SASP. Volume 1: Executive summary
1231. Pharmacokinetics of Salazosulfapyridine (Sulfasalazine, SASP)(IV): Pharmacokinetics of SASP in the rat following consecutive oral doses.
1232. SASP/” target=”_blank” rel=”noopener” data-saferedirecturl=”https://www.google.com/url?q=https://transhumanist-party.org/tag/SASP/&source=gmail&ust=1579109268616000&usg=AFQjCNHXsxzxNxwQBGqCzklmOCoFKpYYsg”>Browsed by Tag: SASP
1233. Treating 150 Cases with Active Ankylosing Spondylitis with Chinese Peashrub Root Powder Capsule combined with SASP
1234. TOE MANIPULATIVE THERAPISTS’GROUP OF THE SASP
1235. … of long term radionuclide data for lead-210 and beryllium-7 collected at Murdoch University for the Surface Air Sampling Program (SASP) of the Environmental …
1236. Human SLE bone marrow mesenchymal stem cells (BMSCs) have a senescence-associated secretory phenotype (SASP) mediated by a MAVS-IFNβ …
1237. Secondary amine selective Petasis (SASP) bioconjugation
1238. The senescence-associated secretory phenotype (SASP) from mesenchymal stromal cells impairs growth of immortalized prostate cells but has no effect on …
1239. Convergent validity of the Richmond Reversal Rating in relation to visual-spatial perception as measured by the SASP
1240. In Search of Nutritional Anti-Aging Targets: TOR Inhibitors, SASP Modulators And BCL-2 Family Suppressors
1241. Non-overlapping roles of the RP and p19Arf pathways in protecting oncogenic induced HCC and their roles to modulate SASP
1242. XXth Symposium on Atomic, Cluster and Surface Physics 2016 (SASP 2016)
1243. Hep:: HepNames:: Institutions:: Conferences:: Jobs:: Experiments:: Journals:: Help Home> Conferences> DASS/SASP (Dual Arm Spectrometer System …
1244. 14 ANALYSIS OF SASP REFERENCES: INSIGHTS FOR EFFECTIVE CONTINUING MEDICAL EDUCATION FOR UROLOGISTS
1245. Correction to: Optimisation of a screening platform for determining IL-6 inflammatory signalling in the senescence-associated secretory phenotype (SASP)
1246. Brief Overview of the ECJ Judgement in the Case of Olympique Lyonais SASP v. Olivier Bernard and Newcastle United Football Club
1247. The Senescence-Associated Secretory Phenotype (SASP) and Redox-Dependent Invasion of Metastatic Cancer Cells
1248. PO-112 The senescence associated secretory phenotype (SASP)-factor ccl2 fosters vascular dysfunction and endothelial cell loss in radiation-induced lung disease
1249. Efficacy of artemisinin and SASP on chicken coccidiosis induced by Eimeria tenella.
1250. AISA can control the inflammatory facet of SASP
1251. Momentum Calibration for the SASP Spectrometer
1252. … Article Folic Acid Supplementation Suppresses Sleep Deprivation-Induced Telomere Dysfunction and Senescence-Associated Secretory Phenotype (SASP)
1253. Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase
1254. SASP. Contributions to the 13. Symposium on atomic and surface physics and related topics
1255. Folic Acid Supplementation Suppresses Sleep Deprivation-Induced Telomere Dysfunction and Senescence-Associated Secretory Phenotype (SASP)
1256. SKYNET Applications Software Package (SASP) Operator’s and User’s Handbook.
1257. Unmasking senescence: context-dependent effects of SASP in cancer
1258. VOLUME II-TECHNICAL REPORT PART A SASP SPECIAL EMPHASIS TRADE STUDIES’k
1259. Sexual Assault Services Program (SASP) and Sexual Offense Services (SOS)
1260. Review of Best Practices for ICJI Program Areas: Sexual Assault Services Program (SASP) and Sexual Offense Services (SOS)
1261. Chronic resveratrol treatment inhibits MRC5 fibroblast SASP-related pro-tumoral effects on melanoma cells
1262. P10 CELL SURFACE INTERLEUKIN-1α, WHICH DRIVES THE SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP), IS TETHERED VIA IL …
1263. The annual meeting of the Scandinavian Association for the Study of Pain (SASP) 18-20 April 2018− S1
1264. Science and Applications Space Platform (SASP) End-to-End Data System Study
1265. … Responses and Protection in Dairy Cows Vaccinated withStaphylococcus aureusSurface Proteins (SASP) andStaphylococcus chromogenes Surface Proteins …
1266. … /REPERFUSION (I/R) INDUCED INFLAMMAGING BY INHIBITING SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) IN TUBULAR EPITHELIAL …
1267. SASP-Symposium on atomic, cluster and surface physics’ 94
1268. The Triumf Second Arm Spectrometer System (SASP)
1269. Proceedings of the DASS/SASP (Dual Arm Spectrometer System/Second Arm Spectrometer) Workshop, Vancouver, March 17-18, 1986
1270. The Abstracts of SASP 2001: The Seventh Annual Meeting of the Society of Australasian Social Psychologists
1271. SASP’86: Symposium on atomic and surface physics
1272. 1‐Amino‐2‐(Silyloxymethyl) Pyrrolidines (SASP)
1273. Address at the opening Jubilee Congress of the SASP by the Minister of Health and Welfare
1274. SASP. Symposium on atomic and surface physics’ 82. Contributions

[HTML] Senolytics: A Translational Bridge Between Cellular Senescence and Organismal Aging

BIOMARKERS FOR CELLULAR SENESCENCE

[HTML] Potential Role of Cellular Senescence in Asthma

The Heterogeneity of Senescent Cells

Perspectives of the potential implications of polyphenols in influencing the interrelationship between oxi-inflammatory stress, cellular senescence and …

[PDF] Special issue on “Molecular genetics of aging and longevity”: a critical time in the field of geroscience

Pharmacotherapy to gene editing: potential therapeutic approaches for Hutchinson–Gilford progeria syndrome

[PDF] Establishment of a Temperature-Sensitive Model of Oncogene-Induced Senescence in Angiosarcoma Cells

A Costa, MY Bonner, S Rao, L Gilbert, M Sasaki… – Cancers, 2020

… the nonpermissive temperature. This suggests that the maintenance of the senescent phenotype results in a low level of p38 signaling and that p38 activators might be effective in mediating senolytic therapies. Consistent with …

Cancer as a disease of old age: changing mutational and microenvironmental landscapes

E Laconi, F Marongiu, J DeGregori – British Journal of Cancer, 2020

Why do we get cancer mostly when we are old? According to current paradigms, the answer is simple: mutations accumulate in our tissues throughout life, and some of these mutations contribute to cancers.

Preadipocyte secretory factors differentially modulate murine macrophage functions during aging which are reversed by the application of phytochemical EGCG

R Kumar, A Sharma, Y Padwad, R Sharma – Biogerontology

… Working on green tea EGCG, we have previously reported its anti- immunosenescence, anti-inflammatory, anti-senescence, senolytic and synbiotic attributes thereby suggesting its multi-faceted potency as an …

[PDF] Novel properties of mature adipocytes in obesity and hyperinsulinemia

Q Li – 2020

Page 1. From the Department of Cell and Molecular Biology Karolinska Institutet, Stockholm, Sweden Novel properties of mature adipocytes in obesity and hyperinsulinemia Qian Li 李 倩 Stockholm 2020 Page 2. Cover picture …

[PDF] Establishment of a Temperature-Sensitive Model of Oncogene-Induced Senescence in Angiosarcoma Cells

A Costa, MY Bonner, S Rao, L Gilbert, M Sasaki… – Cancers, 2020

… the nonpermissive temperature. This suggests that the maintenance of the senescent phenotype results in a low level of p38 signaling and that p38 activators might be effective in mediating senolytic therapies. Consistent with …

Cancer as a disease of old age: changing mutational and microenvironmental landscapes

E Laconi, F Marongiu, J DeGregori – British Journal of Cancer, 2020

Why do we get cancer mostly when we are old? According to current paradigms, the answer is simple: mutations accumulate in our tissues throughout life, and some of these mutations contribute to cancers. Although …

Preadipocyte secretory factors differentially modulate murine macrophage functions during aging which are reversed by the application of phytochemical EGCG

R Kumar, A Sharma, Y Padwad, R Sharma – Biogerontology

… Working on green tea EGCG, we have previously reported its anti- immunosenescence, anti-inflammatory, anti-senescence, senolytic and synbiotic attributes thereby suggesting its multi-faceted potency as an …

[PDF] Novel properties of mature adipocytes in obesity and hyperinsulinemia

Q Li – 2020

Page 1. From the Department of Cell and Molecular Biology Karolinska Institutet, Stockholm, Sweden Novel properties of mature adipocytes in obesity and hyperinsulinemia Qian Li 李 倩 Stockholm 2020 Page 2. Cover picture …

Targeted reduction of senescent cell burden alleviates focal radiotherapy-related bone loss.

A Chandra, AB Lagnado, JN Farr, DG Monroe, S Park… – Journal of bone and mineral …, 2020

… To test if senolytic drugs, which clear senescent cells, alleviate FRT-related bone damage, we administered the senolytic agents, Dasatinib (D), Quercetin (Q), Fisetin (F), and a cocktail of D and Q (D+Q). We found moderate …

Treating cognitive decline and other neurodegenerative conditions by selectively removing senescent cells from neurological tissue

RM Laberge, J Campisi, M Demaria, N David… – US Patent App. 16/584,638, 2020

… US 20200030323 A1 US20200030323 A1 US 20200030323A1 US 201916584638 A US201916584638 A US 201916584638A US 2020030323 A1 US2020030323 A1 US 2020030323A1 Authority US United States Prior …

[HTML] Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis

T Montero-Melendez, A Nagano, C Chelala, A Filer… – Nature Communications, 2020

Rheumatoid arthritis affects individuals commonly during the most productive years of adulthood. Poor response rates and high costs associated with treatment mandate the search for new therapies. Here we show that targeting a specific …

[HTML] SENEBLOC, a long non-coding RNA suppresses senescence via p53-dependent and independent mechanisms

CL Xu, B Sang, GZ Liu, JM Li, XD Zhang, LX Liu… – Nucleic Acids Research, 2020

… Moreover, SENEBLOC was shown to be involved in both oncogenic and replicative senes- cence, and from the perspective of senolytic agents we show that the antagonistic actions of rapamycin on senescence are dependent on SENEBLOC ex- pression …

Repurposing cell penetrating peptides and their novel derivatives and iopromide and iodo-aryl carbonates for treatment of senescence-related diseases and disorders

SS Çinarouglu, E Timucin, GB Akcapinar, U Sezerman… – US Patent App. 16/526,997, 2020

… US2020031873A1 US 20200031873 A1 US20200031873 A1 US 20200031873A1 US 201916526997 A US201916526997 A US 201916526997A US 2020031873 A1 US2020031873 A1 US 2020031873A1 …

[HTML] Implications of Oxidative Stress and Cellular Senescence in Age-Related Thymus Involution

A Barbouti, PVS Vasileiou, K Evangelou, KG Vlasis… – Oxidative Medicine and …, 2020

The human thymus is a primary lymphoepithelial organ which supports the production of self-tolerant T cells with competent and regulatory functions. Paradoxically, despite the crucial role that it exerts in T cell-mediated immunity …

[HTML] Taking in consideration the bystander effects of articular senescence

JM Brondello, YM Pers – Annals of Translational Medicine, 2019

… harboring shorten telomeres, by accumulating cycle-dependent kinases inhibitors driving senescence such as p16 Ink4a , p21 Cdkn1A and p57 KIP2 , and finally by producing deleterious catabolic and inflammatory mediators …

RNA Biology Provides New Therapeutic Targets for Human

LW Harries – Role of RNA Modification in Disease, 2020

… For example, strategies are emerging now which allow selective delivery of senolytic cargoes to senescent cells only using galactosaccharide nanoparticles, which harness the observation that senescent cells harbor …

The ageing epigenome and its rejuvenation

W Zhang, J Qu, GH Liu, JCI Belmonte – Nature Reviews Molecular Cell Biology, 2020

Ageing is characterized by the functional decline of tissues and organs and the increased risk of ageing-associated disorders. Several ‘rejuvenating’ interventions have been proposed to delay ageing and the onset of …

[PDF] Beyond Tumor Suppression: Senescence in Cancer Stemness and Tumor Dormancy

F Triana-Martínez, MI Loza, E Domínguez – Cells, 2020

… with the promise of future directions on innovative anticancer therapies. Keywords: cellular senescence; stemness; dormancy; quiescence; senolytic 1. Introduction Natural tumor evolution is a complex process, composed of …

The Heterogeneity of Senescent Cells

NK September

… However, there is no single senolytic that has been shown to target all of our senescent cells … One example is Cleara Biotechnologies, whose founder, Dr. Peter De Keizer, has talked about senolytic “cocktails” and the problem …

[PDF] Regorafenib Alteration of the BCL-xL/MCL-1 Ratio Provides a Therapeutic Opportunity for BH3-Mimetics in Hepatocellular Carcinoma Models

B Cucarull, A Tutusaus, M Subías, M Stefanovic… – Cancers, 2020

… A-1331852 has been proposed as an agent in cancer therapy [42,43] and, more recently, as a senolytic compound [44]. Interestingly, through a dual mechanism acting on senescent cholangiocytes and activated fibroblasts …

Cellular Senescence and Tumor Promotion

M Demaria – Geriatric Oncology

… rejuvenation of aged-tissue stem cells (Childs et al. 2017; Soto- Gamez and Demaria 2017). Currently, a limited number of senolytic agents have been identified. 2-DG, a false substrate for the glycolytic metabolism, or bafilomycin A1, a

[PDF] Henry Ford Health System Scholarly Common s

DE Citrin, PGS Prasanna, AJ Walker, ML Freeman…

… this setting. Although preventing premature senescence has shown promise in preventing RIF, there is increasing interest in agents that can clear prematurely senescent cells from tissues using “senolytic” drugs. Indeed, clearance …

The role of adipose tissue senescence in obesity-and ageing-related metabolic disorders

Z Liu, KKL Wu, X Jiang, A Xu, KKY Cheng – Clinical Science, 2020

Skip to Main Content …

[PDF] Stress-induced Cellular Senescence Contributes to Chronic Inflammation and Cancer Progression

S KOBASHIGAWA, YM SAKAGUCHI, S MASUNAGA… – Thermal Medicine, 2019

… In addition, a recent study demonstrated the efficacy of senolytic drugs in the selective elimination of senescent cells123); a combined treatment of dasatinib and quercetin (D＋Q) was found to reduce the number of senescent …

[PDF] Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice

MJ Yousefzadeh, J Zhao, C Bukata, EA Wade… – Aging Cell

Abstract Senescent cells accumulate with age in vertebrates and promote aging largely through their senescence‐associated secretory phenotype (SASP). Many types of stress induce senescence, includi…

Cardiac Glycosides as Senolytic Compounds

N Martin, O Soriani, D Bernard – Trends in Molecular Medicine, 2020

The identification of senolytics, compounds that eliminate senescent cells, is presently a key priority given their therapeutic promise in cancer and aging-associated diseases. Two recent papers by Triana-Martínez et al. and Guerrero et al …

[HTML] Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype

AJ Barinda, K Ikeda, DB Nugroho, DA Wardhana… – Nature Communications, 2020

Vascular senescence is thought to play a crucial role in an ageing-associated decline of organ functions; however, whether vascular senescence is causally implicated in age-related disease remains unclear. Here we show that …

[HTML] Urogenital Support

BI Blog, ADN Booster

… Current research has shown that certain plant polyphenols (ie quercetin and fisetin) are strong senolytic agents (molecules that stop senescence), and have exciting potential for reducing and preventing senescence, which …

[PDF] Transplanting cells from old but not young donors causes physical dysfunction in older recipients

B Wang, Z Liu, VP Chen, L Wang, CL Inman, Y Zhou… – Aging Cell

… Our study potentially begins new avenues of research to discover whether pharmacological interventions, such as senolytic drugs (Tchkonia & Kirkland, 2018) or anti‐inflammatory drugs, can prevent or reverse dysfunction caused …

[PDF] Preclinical Pharmacological Activities of Epigallocatechin-3-gallate in Signaling Pathways: An Update on Cancer

M Sharifi-Rad, R Pezzani, M Redaelli, M Zorzan… – Molecules, 2020

Page 1. Molecules 2020, 25, 467; doi:10.3390/molecules25030467 www.mdpi.com/ journal/molecules Review Preclinical Pharmacological Activities of Epigallocatechin- 3-gallate in Signaling Pathways: An Update on Cancer

Senolytic compositions and uses thereof

MA Gallop, J Klein, M Quarta – US Patent App. 16/508,477, 2020

UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound data: image/svg+xml; base64, PD94bWwgdmVyc2lvbj0nMS4wJyBlbm…/+ IDwvcmVjdD4KPHBhdGggY2xhc3M9J2…+Cjx0ZXh0IHg9JzIyOS45MjQnIHk9JzE1… PHRzcGFuPkg8L3RzcGFuPjwvdGV4d …

Impaired Myofibroblast Dedifferentiation Contributes to Non-Resolving Fibrosis in Aging

K Kato, NJ Logsdon, YJ Shin, S Palumbo, A Knox… – American Journal of …, 2020

… One study demonstrated that the senolytic agent, quercetin, restored apoptosis susceptibility in IPF lung myofibroblasts, and inhibited fibrotic responses to lung injury in aged mice (62). Further, the first-in-human pilot study with a senolytic …

[HTML] Browsed by Tag: Mitochondrial mutations

N Bagalà, S Hill

[PDF] Cellular senescence contributes to age‐dependent changes in circulating extracellular vesicle cargo and function

FJ Alibhai, F Lim, A Yeganeh, PV DiStefano… – Aging Cell

… Instead, we show that cellular senescence contributes to changes in particle cargo and function. Notably, senolytictreatment of old mice shifted plasma particle cargo and function toward that of a younger phenotype.

Therapy-induced senescence—an induced synthetic lethality in liver cancer?

K Wolter, L Zender – Nature Reviews Gastroenterology & Hepatology, 2020

… cells. Therefore, the directed use of senolytic therapies in human cancers necessitates imaging modalities to non-invasively visualize TIS, thereby enabling image-guidedapplications of senolytic therapies. Full size image. Two …

Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice.

MB Cavalcante, TD Saccon, ADC Nunes, JL Kirkland… – Aging, 2020

… Collagen deposition in the uterus is related to uterine aging. Senolytic therapies are an option for reducing health complications related to aging. We investigated effects of agingand the senolytic drug combination of dasatinib plus quercetin (D+Q) on uterine fibrosis …

[HTML] CMV-independent increase in CD27− CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians

C Martin-Ruiz, J Hoffmann, E Shmeleva, T von Zglinicki… – npj Aging and Mechanisms …, 2020

… p < 0.001; **p < 0.01; *p < 0.05 using 1-way ANOVA. Full size image. Senolytic therapy … The gating scheme is depicted in Fig. 2a. Animals, procedures and senolytictreatment. C57BL/6 mice were analyzed at either …

Dasatinib, a second-generation tyrosine kinase inhibitor, induces melanogenesis via ERK-CREB-MITF-tyrosinase signaling in normal human melanocytes

B Kang, Y Kim, TJ Park, HY Kang – Biochemical and Biophysical Research …, 2020

… allergic asthma. Br. J. Pharmacol., 173 (2016), pp. 1236-1247. Google Scholar. [8] JL Kirkland, T. Tchkonia, Y. Zhu, LJ Niedernhofer, PD RobbinsThe clinical potential of senolytic drugs. J. Am. Geriatr. Soc., 65 (2017), pp. 2297 …

[PDF] The role of the microbiota in sedentary life style disorders and ageing: Lessons from the animal kingdom

PW O’Toole, PG Shiels – Journal of Internal Medicine, 2020

… Nrf2 regulates over 390 stress defence genes linked to longevity and health span. Moreover, alkyl catechols comprise a group of chemicals that include the senolytic agents fisetin and quercetin, which have proven efficacy in …

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G Stolyarov II, A Grases

… When I am 85, the senolytic DNA machinery will be far from the only addition to my cells … Inflammatory conditions of aging will be a shadow of what they once were, because of senolytic therapies presently under development …

Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation–induced impairment of neurovascular coupling responses protecting …

A Yabluchanskiy, S Tarantini, P Balasubramanian… – GeroScience

… Data are expressed as mean ± SEM. Results. WBI induces astrocyte senescence: protective effects of senolytictreatments … 3d, e). WBI impairs eicosanoid gliotransmitter-mediated NVC responses: protective effects of senolytictreatments …

[HTML] Astrocyte Support for Oligodendrocyte Differentiation can be Conveyed via Extracellular Vesicles but Diminishes with Age

CM Willis, AM Nicaise, ER Bongarzone, M Givogri… – Scientific Reports, 2020

The aging brain is associated with significant changes in physiology that alter the tissue microenvironment of the central nervous system (CNS). In the aged CNS, increased demyelination has been associated with astrocyte hypertrophy …

[HTML] TGF-β1/IL-11/MEK/ERK signaling mediates senescence-associated pulmonary fibrosis in a stress-induced premature senescence model of Bmi-1 deficiency

H Chen, H Chen, J Liang, X Gu, J Zhou, C Xie, X Lv… – Experimental & Molecular …, 2020

To study whether TGF-β1/IL-11/MEK/ERK (TIME) signaling mediates senescence-associated pulmonary fibrosis (SAPF) in Bmi-1-deficient (Bmi-1−/−) mice and determines the major downstream mediator of Bmi-1 …

[HTML] Underlying Histopathology Determines Response to Oxidative Stress in Cultured Human Primary Proximal Tubular Epithelial Cells

MA Khan, X Wang, KTK Giuliani, P Nag, A Grivei… – International Journal of …, 2020

Proximal tubular epithelial cells (PTEC) are key players in the progression of kidney diseases. PTEC studies to date have primarily used mouse models and transformed human PTEC lines. However, the translatability of these …

[HTML] Metabolic Syndrome Support

BI Blog, HIA You

… Current research has shown that certain plant polyphenols (ie quercetin and fisetin) are strong senolytic agents (molecules that stop senescence), and have exciting potential for reducing and preventing senescence, which …

PDF] Senescent Colon and Breast Cancer Cells Induced by Doxorubicin Exhibit Enhanced Sensitivity to Curcumin, Caffeine, and Thymoquinone

Targeting defective pulmonary innate immunity–A new therapeutic option?

Targeting the progression of chronic kidney disease

Cellular senescence: from anti-cancer weapon to anti-aging target

[PDF] Targeting Age-Related Pathways in Heart Failure

[HTML] Autophagy Reprograms Alveolar Progenitor Cell Metabolism in Response to Lung Injury

[HTML] A Newly Synthesized Rhamnoside Derivative Alleviates Alzheimer’s Amyloid-β-Induced Oxidative Stress, Mitochondrial Dysfunction, and Cell Senescence through …