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    • ABOUT
    • SCIENTIFIC STUDIES
      • ALLERGIES & CYTOKINES
      • ANTI-ACNE EFFECT OF FLAVONOIDS AND POLYPHENOLS
      • ADVANCED GLYCATION END PRODUCTS (AGES)
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    MDM2
    January 10, 2020
    Andrographis Paniculata
    January 14, 2020

    SHIPPING APRIL 15TH!!!

    Interstellar Blend Senolytic Zombie Senescent Cell Killer

    ZOMBIE CELL KILLER

     

    News Articles:

    •  Both Senolytic Molecules Are Inhibitors Of Particular Members Of The Bcl-2 Family Of Apoptosis Regulatory Proteins And Have Distinct Pharmacokinetic Profiles.
    • ‘One Of The Most Important Aging Discoveries Ever’
    • 100 Is The New 60: The Transformation Of Healthcare
    • 12 Innovations That Could Make Reverse Aging A Reality
    • 1St Age Reversal Results—Is It Hgh Or Something Else?
    • 20 Technology Metatrends That Will Define The Next Decade
    • 3 Most Important Breakthrough In Biology Of 2019
    • 9 Ways To Stay Healthy As You Age
    • A Cell-Killing Strategy To Slow Aging Passed Its First Test This Year
    • A ‘One-Two Punch’ To Wipe Out Cancerous Ovarian Cells
    • A True Fountain-Of-Youth Drug Combo?
    • Advances In Antiaging Research: Chemistry Could Hold The Key To Better Health
    • Advances In The Science Of Aging
    • Ageing In Human Cells Successfully Reversed In The Lab
    • Age-Related Enfeeblement Of The Immune System Speeds Build-Up Of Senescent Cells
    • Anti-Ageing Drug On The Horizon: Scientists Discover Medicine Cocktail That Clears ‘Zombie Cells‘
    • ‘Anti-Ageing‘ Drugs Could Be On The Market In Five Years If Clinical Trials Prove Successful
    • Anti-Aging Drugs And Toxic Cells
    • Anti-Aging Drugs Are Showing Promise In Human Trials
    • Anti-Aging Drugs Could Be On The Market In The Next 5 Years
    • Anti-Aging Field ‘Explodes’ In Pursuit Of Healthy Old Age
    • Anti-Aging Mechanism May Hold Key To ‘Perfect’ Osteoporosis Treatment
    • Anti-Aging Senolytic Cocktail Passes First Human Trial
    • Anti-Aging Senolytics Drugs Found To Improve Mice Health And Lifespan
    • Antibiotics Eliminate Senescent Cells Associated With Ageing
    • Antoxerene Closes $10 Million Deal With Juvenescence To Develop Small Molecule Drugs For Diseases Of Aging
    • Are Tauopathies Caused By Neuronal And Glial Senescence?
    • Ascentage Pharma And Unity Biotechnology Announce Collaboration For The Development Of Senolytic Healthspan Therapies
    • Ascentage Pharma, Unity Biotech Collab To ‘Cure Old Age’
    • Can A Single Pill Keep You Healthy To 100?
    • Can We Live Forever? | Feature
    • Cell Aging In Lung Epithelial Cells
    • Cellular Sickness Linked To Type 1 Diabetes Onset
    • Clearing Old Cells From Mouse Brains Lowered Signs Of Anxiety
    • Clearing Out Brain’S “Zombie Cells” Offers New Approach Against Dementia
    • Concerns Rise Over Negative Impact Of Hev Light On Skin As Companies Delve Into Anti-Aging Therapeutics
    • Could An Existing Heart Drug Help Treat Cancer?
    • Could One Pill Cure A Host Of Diseases? Killing ‘Zombie‘ Cells To Improve Health In Old Age
    • Cover Story: Investing In The Ageing Population Theme
    • Diet, Physical Activity Among Keys To Healthy Brain
    • Discovery Offers Hope For Improving Physical Performance As We Age
    • Eat Glutathione
    • Editor’S Letter: The Precision Medicine Issue
    • Elixir Of Life: Scientists Find Way To Reverse Cell Damage Caused By Ageing
    • Emerging Evidence Shows Wider Benefits Of Supplements
    • Epigenetics And Aging
    • Experts Propose New Healthcare Framework To Help Ageing Populations Stay Healthier Longer
    • Extending Healthspan May Be Coming Soon
    • Fascinating Picture Shows Anti-Ageing Drugs Really Do Work
    • Finally, The Drug That Keeps You Young
    • First-In-Human Trial Of Senolytic Drugs Encouraging
    • Fisetin May Be An Effective Senolytic
    • Fisetin Within Strawberries Clears Senescent Cells
    • Fisetin—A New Senolytic
    • Fountains Of Youth: Biotech Startups Emerge From Stealth Mode To ‘Take On Aging’
    • Foxbio: $10M Jv Launched To Target Age-Related Disease
    • Global Longevity And Anti-Senescence Therapy Market
    • Global Longevity And Anti-Senescence Therapy Market 2019-2023 – Focus On Senolytic Drug Therapy, Gene Therapy, Immunotherapy And Others
    • Herb Leaf Eaten By Japanese Samurai Found To Slow Down Ageing By Clearing Out Disease-Causing Cells
    • Here Are 5 Things You Should Start Doing Today To Live Longer
    • How Genome Sequencing And Senolytics Can Help Us Live Healthier, Longer
    • How Silicon Valley Billionaires Claim They’Ve Discovered The Secret To Everlasting Life
    • How This Man Genuinely Expects To Live To 200 (And Has Invested $100M To Discover The Secret)
    • How To Live Longer: The Science Of Ageing, And How To Slow It Down
    • Https://Endpts.Com/Harvard-Prof-David-Sinclair-Backs-Anti-Aging-Upstart-Life-Bio-Which-Just-Raised-50M-For-Research/
    • Human Drug Trial In San Antonio Offers Hope To Those With Age-Related Diseases
    • Humans ‘Biohacking’ Their Own Bodies With Blood Transfusions To Achieve ‘Diy Immortality’
    • In Search For ‘Perfect’ Osteoporosis Treatment, Consider Key Anti-Aging Mechanism
    • Ipf Treatment Options May Be Boosted By Senolytic Drugs
    • Is Cellular Senescence The Key To Naked Mole Rats’ Long, Cancer-Free Life?
    • Is Fasting Senolytic?
    • Is Metformin The Key To Living Longer? | The Times Magazine
    • Is The Cancer Drug Dasatinib The Anti-Aging Breakthrough We Have All Been Waiting For?
    • Is There Any Truth To Anti-Aging Schemes?
    • Journal Of The American Medical Association Shines Spotlight On Geroscience
    • Juvenescence Closes First Tranche Of Series B Enabling Further Growth And Development
    • Juvenescence Raises Another $100M To Invest In Longevity
    • Kalter: Fountain Of Youth?
    • Kidney Disease: Senescent Cell Burden Is Reduced In Humans By Senolytic Drugs
    • Kill Senescent Cells Before They Kill You
    • Killing ‘Zombie Cells‘ Cures Anxiety In Obese Mice
    • Letter To An Incipient Cancer Survivor
    • Life Biosciences Joins The Longevity Race
    • Life Biosciences Raises $50M As Longevity Race Heats Up
    • Life Biosciences: A New Paradigm For Approaching Longevity Research
    • Lifespan Extended, Health Improved By Senolytic Drugs
    • Link Between Aging, Devastating Lung Disease Discovered
    • Link Between Cells Associated With Aging, Bone Loss
    • Longevity And Anti-Senescence Therapy Market 2019 Global Analysis, Opportunities And Forecast To 2024
    • Longevity And Anti-Senescence Therapy Market, 2023 – Emphasis On Stem Cell Research And Increasing Demand For Cell-Based Assays
    • Longevity Company Unity Biotechnology Stocks Soared After Ceo Talks To Cnbc
    • ‘Longevity‘ Could Reach Billions In 2019 – And Is No Longer Just The Preserve Of Billionaires
    • Mayo Clinic Discovery Could Extend Quality Of Life
    • Mayo Clinic May Be Onto The Fountain Of Youth
    • Mayo Clinic Showcases Anti-Aging Senolytics
    • Mayo Clinic Takes Next Step In Anti-Aging Research
    • Molecule Kills Elderly Cells, Reduces Signs Of Aging In Mice
    • Money In Aging Research, Part I
    • Money In Aging Research, Part Ii
    • Mouse Model Shows Success Of Senolytic Drugs In Reversing Senescent Cell Damage
    • Natural Compounds That Remove Aging Cells
    • Nature Medicine Study Describes A Novel Senolytic Molecule That Slows The Progression Of Osteoarthritis
    • Never Grow Up: The Anti-Aging Market Is A $200B Industry
    • New Cause Of Cell Aging Uncovered
    • New Class Of ‘Transformative’ Anti-Aging Drugs Set For Human Trials
    • Novato Startup Unity Biotechnology Tackles Arthritis, Glaucoma
    • Obese Mice Lose Anxiety When ‘Zombie Cells‘ Exit Their Brain
    • Osteoporosis: Potential New Drug Target Uncovered
    • Parp Inhibitors Used In ‘One-Two Punch’ Strategy To Kill Oc Cells In Mouse Models, Study Shows
    • Peninsula Anti-Aging Drug Company Files For $85M Ipo
    • Plaques Age Glial Precursors, Stoking Inflammation
    • Purging Failed Brain Insulation Cells Lessened Damage, Improved Cognition In Alzheimer’S Mouse Model
    • Reducing ‘Zombie‘ Cells May Slow The Aging Process
    • Rejuvenating Senolytics
    • Rejuvenation At The Cell Level
    • Removal Of ‘Zombie Cells‘ Alleviates Causes Of Diabetes In Obese Mice
    • Removing “Zombie Fat Cells” A Way Forward For Treating Diabetes
    • Research Shows It’S Possible To Reverse Damage Caused By Aging Cells
    • Researchers Discover New Cause Of Cell Aging
    • Researchers Discover Way To Slow Aging Process
    • Researchers Identify Molecule With Anti-Aging Effects On Vascular System, Study Finds
    • Researchers May Have Discovered”Fountain Of Youth” Drugs
    • Restoring Brain Function In Mice With Symptoms Of Alzheimer’S Disease
    • Rewinding The Clock
    • Rumors Of Age Reversal: The Plasma Fraction Cure
    • Scaling The Alzheimer’S Cure
    • Scientists Discover Cell Aging Linked To Nucleotide Synthesis
    • Scientists Harness Ai To Reverse Ageing In Billion-Dollar Industry
    • Scientists Hunt Zombie Cells: ‘The Grand Challenge’
    • Scientists Mark Success In First Human Test Of Novel Anti-Aging Therapy
    • Scientists Pinpoint A Natural Compound That Helps Us Stave Off Aging
    • Scientists Slow Ageing With Green Tea, Onions, Red Wine
    • Scientists Take A Step Towards Beating The Pain Of Old Age
    • Screening Method Identifies Compounds That Extend Lifespan In Mice
    • Senescent Cell Burden Is Reduced In Humans By Senolytic Drugs
    • Senescent Cell Research Moves Into Human Trials
    • Senescent Cells May Play A Role In Thrombosis
    • Senescent Cells Play An Essential Role In Wound Healing
    • Senolytic Drugs Increase Lifespan, Improve Physical Function In Aging Mice | Medicine
    • Senolytic Drugs May Offer New Ipf Therapy Options
    • Senolytic Drugs May Reverse Damage Caused By Senescent Cells
    • Senolytic Drugs Reverse Damage Caused By Senescent Cells In Mice
    • Senolytic Therapeutics Kicks Off Q1 2019 With High-Profile Speaking Events
    • Senolytic Therapeutics Y Quibim, Industria De La Longevidad Con Adn Valenciano
    • Senolytic Therapies And The Quest To Cure Aging
    • Senolytic Therapies For Healthy Longevity
    • Senolytic Treatment Improves Physical Function In Ipf Patients, According To Small Pilot Study
    • Senolytics Against Aging: Snapshot Of A Fast-Moving Field
    • Senolytics Show Promise Against Alzheimer’S In Mice
    • Senolytics: Living Healthier For Longer With A New Class Of Drugs
    • Senolytics: Scientists Identify New Drug That Slows The Ageing Process And Could Dramatically Increase Our Life Expectancy
    • Six Columbia Cancer Researchers Receive Seed Funding From Velocity
    • ‘Sleeping Cells‘ Drive A Host Of Age-Related Diseases — And New Drugs Are Seeking To Rid Them From Our Bodies
    • Steadman Philippon Research Institute To Share Four Dod Research Grants Aimed At Reducing Risk Of Osteoarthritis & Reducing Long-Term Disability Among Military Service Members And Veterans
    • Study: Eating Red Meat May Not Be That Bad For You
    • Sweep Away Senile Cells
    • Targeting Senescent Cells Increases Bone Mass
    • Tau Tangles Cleared By Senolytic Drugs In Alzheimer’S Mice
    • The Biological Fountain Of Youth? ‘Anti-Aging’ Therapy Close To Clinical Trials
    • The Ethics Of Anti-Ageing: Where Do We Draw The Line?
    • The First Drugs Designed To Fight Aging Are Ready For Human Testing, Scientists Say
    • The Future Of Aging: Bringing Hollywood To The Hospital
    • The Longevity Industry Comes Of Age
    • The Most Effective Personal Anti-Aging Program
    • The Science Of Senolytics: How A New Pill Could Spell The End Of Ageing
    • The Top 10 Companies Working To Increase Longevity
    • The Transhumanists Who Want To Live Forever
    • The War On Aging: An Update From The Front Lines – H+ Media
    • The Wonder Drug That Could Reverse The Ageing Process
    • This Drug Combo Extends Lifespan And Healthspan In Mice By Killing ‘Zombie’ Cells
    • This Is An Important Step In Assessing The Role That A Senolytic Agent May Play In The Treatment Of Osteoarthritis
    • This Russian Millionaire Wants To Help People Live To 200 Years Old
    • To Stay Young, Kill Zombie Cells
    • Top Companies Working To Extend Longevity
    • Transfusions Of Young Blood Could Hold Key To Longer Life, Scientists Say
    • Two Clinically-Approved Antibiotics Eliminate Senescent Cells Associated With Ageing
    • Unity Takes Up Option On Ascentage Aging Drug
    • Want To Live For Ever? Flush Out Your Zombie Cells
    • What Is Fisetin? Product Found In Fruits And Vegetables May Slow Aging, Researchers Show
    • What This Biotech’S $85 Million Ipo Tells Us About Raging Against Aging
    • When Aging Is Fun
    • Why A Drug For Aging Would Challenge Washington
    • Why Jeff Bezos Is Backing This Silicon Valley Scientist Who Is Working On A Cure For Aging
    • Why You Shouldn’T Fear The Gray Tsunami
    • Will Age Soon Really Just Be A Number?
    • Will We Soon Be Taking A Pill To Slow Aging?
    • Wiping Out The Brain’S Retired Cells Prevents A Hallmark Of Alzheimer’S
    • Wiping Out Zombie Cells In Fat May Delay Or Alleviate Diabetes
    • Zombie Cell Research And Anxiety
    • ‘Zombie Cells‘ Buildup In Your Body May Play Role In Aging

     

    SCIENTIFIC STUDIES:

    1. The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
    2. The Clinical Potential of senolytic Drugs
    3. Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
    4. Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors
    5. Clinical strategies and animal models for developing senolytic agents
    6. senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo
    7. Discovery of piperlongumine as a potential novel lead for the development of senolytic agents
    8. Pleiotropic Effects of Tocotrienols and Quercetin on Cellular senescence: Introducing the Perspective of senolytic Effects of Phytochemicals
    9. A Novel Indication for Panobinostat as a senolytic Drug in NSCLC and HNSCC
    10. Oxidation resistance 1 is a novel senolytic target
    11. Effects of senolytic drugs on human mesenchymal stromal cells
    12. senolytic activity of piperlongumine analogues: Synthesis and biological evaluation
    13. Hsp90 inhibitors as senolytic drugs to extend healthy aging
    14. The curcumin analog EF24 is a novel senolytic agent
    15. senolytic drugs in respiratory medicine: is it an appropriate therapeutic approach?
    16. senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model
    17. Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts
    18. Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin
    19. senolytic Cocktail Dasatinib+Quercetin (D+Q) Does Not Enhance the Efficacy of senescence-Inducing Chemotherapy in Liver Cancer
    20. Emerging senolytic agents derived from natural products
    21. senolytic treatments applied to osteoarthritis: a step towards the end of orthopedic surgery?
    22. Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy
    23. Curcumin and o-Vanillin Exhibit Evidence of senolytic Activity in Human IVD Cells In Vitro
    24. senolytic helpers
    25. senolytic therapies for healthy longevity
    26. Removing Aging Cells With a New Class of senolytic Drug
    27. Quercetin in Idiopathic Pulmonary Fibrosis: Another Brick in the senolytic Wall
    28. SAT0053 Identification of novel drugs with senolytic activity as osteoarthritis therapeutics
    29. Abstract 11299: A Novel senolytic Drug for Aging and Age-Related Cardiometabolic Disorders
    30. Novel Classification Perspective of Geroprotective and senolytic Drugs as an Antiaging Strategy
    31. LSC – 2017 – senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo
    32. senolytic treatment targets aberrant p21-expression to restore liver regeneration in adult mice
    33. Augmented Inflammatory Responses in Aging are Driven by Circulating mtDNA and Ameliorated by senolytic Treatment
    34. senescence Signature in Skin Biopsies From Systemic Sclerosis Patients Treated With senolytic Therapy: Potential Predictor of Clinical Response?
    35. Fenofibrate, a peroxisome proliferator-activated receptor alpha, is a novel molecule with senolytic and autophagy activity for cartilage degeneration and osteoarthritis
    36. senolytic activity of small molecular polyphenols from olive restores chondrocyte redifferentiation and cartilage regeneration in osteoarthritis
    37. Treatment of parkinson’s disease and other conditions caused or mediated by senescent astrocytes using small molecule senolytic agents
    38. Application of ex-vivo spheroid model system for the analysis of senescence and senolytic phenotypes in uterine leiomyoma
    39. AMPK-mediated senolytic and senostatic activity of quercetin surface functionalized Fe3O4 nanoparticles during oxidant-induced senescence in human fibroblasts
    40. Mitochondrial DNA-Mediated Inflammatory Injury in Old Donors Is Improved by senolytic Treatment
    41. The biology of senescence.
    42. Leaf senescence
    43. Cellular senescence in Aging Primates
    44. senescence in premalignant tumours
    45. senescence mechanisms
    46. Cancer, aging and cellular senescence.
    47. The essence of senescence
    48. Four faces of cellular senescence
    49. Microarray analysis of replicative senescence
    50. Aging, Cellular senescence, and Cancer
    51. Molecular aspects of leaf senescence
    52. Cellular senescence in Cancer and Aging
    53. Making Sense of senescence (Molecular Genetic Regulation and Manipulation of Leaf senescence).
    54. Pleiotropy, Natural Selection, and the Evolution of senescence
    55. Cellular senescence as a tumor-suppressor mechanism
    56. Ageing. The biology of senescence.
    57. CHLOROPHYLL DEGRADATION DURING senescence*
    58. The moulding of senescence by natural selection
    59. The molecular biology of leaf senescence
    60. Gene expression during leaf senescence
    61. A new murine model of accelerated senescence
    62. The biology of replicative senescence
    63. The senescence of leaves.
    64. A DNA damage checkpoint response in telomere-initiated senescence
    65. Cellular senescence: from physiology to pathology
    66. Putting the stress on senescence
    67. Rapamycin decelerates cellular senescence
    68. Inhibition of Leaf senescence by Autoregulated Production of Cytokinin
    69. senescence and Postharvest Physiology
    70. Free radicals and senescence
    71. Cellular senescence: when bad things happen to good cells
    72. Bmi1, stem cells, and senescence regulation
    73. The signals and pathways activating cellular senescence
    74. senescence-accelerated mouse (SAM): A novel murine model of senescence
    75. Testosterone Secretion and Metabolism in Male senescence
    76. senescence in Plant Development
    77. Catalase, Peroxidase, and Polyphenoloxidase Activities during Rice Leaf senescence
    78. Replicative senescence: An Old Lives’ Tale?
    79. Transcriptome of Arabidopsis leaf senescence
    80. Nitrogen metabolism and remobilization during senescence
    81. Tumor Cell senescence in Cancer Treatment
    82. senescence Induced by Altered Telomere State, Not Telomere Loss
    83. senescence of Activated Stellate Cells Limits Liver Fibrosis
    84. Telomeres, telomerase and senescence
    85. LABORATORY EVOLUTION OF POSTPONED senescence IN DROSOPHILA MELANOGASTER
    86. Defining senescence and death
    87. Chemokine Signaling via the CXCR2 Receptor Reinforces senescence
    88. FUNGAL senescence
    89. Telomeres, stem cells, senescence, and cancer
    90. Replicative senescence: the human fibroblast comes of age
    91. Evolution of senescence: late survival sacrificed for reproduction
    92. Cellular senescence
    93. SELECTION FOR DELAYED senescence IN DROSOPHILA MELANOGASTER
    94. senescence in tumours: evidence from mice and humans
    95. Fat tissue, aging, and cellular senescence
    96. Inflammatory networks during cellular senescence: causes and consequences
    97. senescence
    98. Role of Ceramide in Cellular senescence
    99. senescence of human fibroblasts induced by oncogenic Raf
    100. Ethylene and flower senescence
    101. Cell senescence and cancer
    102. Therapy-Induced senescence in Cancer
    103. Genes involved in senescence and immortalization
    104. BRAFE600-associated senescence-like cell cycle arrest of human naevi
    105. Vascular Cell senescence
    106. Reversible inhibition of tomato fruit senescence by antisense RNA
    107. A senescent cell bystander effect: senescence‐induced senescence
    108. Molecular regulation of leaf senescence
    109. senescence in a Bacterium with Asymmetric Division
    110. senescence-messaging secretome: SMS-ing cellular stress
    111. Leaf senescence
    112. senescence, Apoptosis or Autophagy?
    113. senescence and immortalization: role of telomeres and telomerase
    114. senescence‐Accelerated Mouse (SAM): A Novel Murine Model of Accelerated senescence
    115. Regulation of cellular senescence by p53
    116. If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells
    117. senescence.7.aspx”>Oxidation and erythrocyte senescence
    118. Formation of MacroH2A-Containing senescence-Associated Heterochromatin Foci and senescence Driven by ASF1a and HIRA
    119. Oncogene-induced senescence as an initial barrier in lymphoma development
    120. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
    121. Tumor suppressors and oncogenes in cellular senescence
    122. senescence in human intervertebral discs
    123. Oncogene-Induced senescence Relayed by an Interleukin-Dependent Inflammatory Network
    124. Cellular senescence and its effector programs
    125. 15 – Whole Plant senescence
    126. Cellular senescence and organismal aging
    127. senescence-Associated Gene Expression during Ozone-Induced Leaf senescence in Arabidopsis
    128. Human senescence
    129. senescence impairs successful reprogramming to pluripotent stem cells
    130. Oncogenic ras Provokes Premature Cell senescence Associated with Accumulation of p53 and p16INK4a
    131. Programmed Cell senescence during Mammalian Embryonic Development
    132. Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
    133. The case for negative senescence
    134. Methods to Detect Biomarkers of Cellular senescence
    135. senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
    136. senescence‐associated β‐galactosidase is lysosomal β‐galactosidase
    137. Akt Determines Replicative senescence and Oxidative or Oncogenic Premature senescence and Sensitizes Cells to Oxidative Apoptosis
    138. Deferral of Leaf senescence with Calcium
    139. Experimental Modification of Plant senescence.
    140. The Activated Oxygen Role of Peroxisomes in senescence
    141. Aging, articular cartilage chondrocyte senescence and osteoarthritis
    142. PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
    143. Pro-senescence therapy for cancer treatment
    144. senescence comes of age
    145. The senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
    146. Oxidative DNA damage and senescence of human diploid fibroblast cells
    147. senescence surveillance of pre-malignant hepatocytes limits liver cancer development
    148. Extreme heat effects on wheat senescence in India
    149. Cellular senescence: putting the paradoxes in perspective
    150. Cellular senescence and cancer treatment
    151. Calcium in plant senescence and fruit ripening
    152. An alternative pathway for yeast telomere maintenance rescues est1− senescence
    153. THE TWO-STAGE MECHANISM CONTROLLING CELLULAR senescence AND IMMORTALIZATION
    154. Ethylene, Plant senescence and Abscission
    155. The molecular genetic analysis of leaf senescence
    156. Hallmarks of senescence in carcinogenesis and cancer therapy
    157. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
    158. Homocysteine accelerates endothelial cell senescence
    159. The molecular analysis of leaf senescence – a genomics approach
    160. A Cellular Timetable of Autumn senescence
    161. MicroRNA-34a regulation of endothelial senescence
    162. Involvement of Hydrogen Peroxide in the Regulation of senescence in Pear
    163. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
    164. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
    165. Deconstructing PML-induced premature senescence
    166. Mortality Patterns Suggest Lack of senescence in Hydra
    167. Plant senescence processes and free radicals
    168. Role of oxidative carbonylation in protein quality control and senescence
    169. Measuring Wheat senescence with a Digital Camera
    170. Brain acetylcholine synthesis declines with senescence
    171. Human cell senescence as a DNA damage response
    172. Molecular genetics of leaf senescence in Arabidopsis
    173. Development and senescence of the Postnatal Bovine Ovary
    174. Leaf senescence in Brassica napus: cloning of senescence related genes by subtractive hybridisation
    175. Alveolar Cell senescence in Patients with Pulmonary Emphysema
    176. Functional senescence in Drosophila melanogaster
    177. Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity
    178. The evolutionary ecology of senescence
    179. Replicative senescence: Implications for in Vivo Aging and Tumor Suppression
    180. SASP reflects senescence
    181. Ethylene regulates the timing of leaf senescence in Arabidopsis
    182. Cellular senescence, cancer and aging: the telomere connection
    183. Control of Jasmonate Biosynthesis and senescence by miR319 Targets
    184. Replicative senescence of Mesenchymal Stem Cells: A Continuous and Organized Process
    185. T-helper-1-cell cytokines drive cancer into senescence
    186. Cellular senescence and tumor suppressor gene p16
    187. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
    188. Telomeres and senescence: Ending the Debate
    189. Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular senescence
    190. The aging brain: morphomolecular senescence of cortical circuits
    191. Reversal of human cellular senescence: roles of the p53 and p16 pathways
    192. Molecular analysis of natural leaf senescence in Arabidopsis thaliana
    193. A transcriptional timetable of autumn senescence
    194. Cellular senescence and cancer
    195. Human SIR2 deacetylates p53 and antagonizes PML/p53‐induced cellular senescence
    196. Telomere dysfunction and tumour suppression: the senescence connection
    197. Many roads lead to oncogene-induced senescence
    198. A negative feedback signaling network underlies oncogene-induced senescence
    199. The anemia of senescence
    200. Plant senescence and crop productivity
    201. Replicative senescence: a critical review
    202. senescence in Health and Disease
    203. A NAC Gene Regulating senescence Improves Grain Protein, Zinc, and Iron Content in Wheat
    204. Last exit: senescence, abscission, and meristem arrest in Arabidopsis.
    205. Memory loss in senescence.
    206. Cigarette Smoke Induces Cellular senescence
    207. Rethinking Chronic Allograft Nephropathy
      The Concept of Accelerated senescence
    208. The sound of senescence
    209. Oncogenic Braf Induces Melanocyte senescence and Melanoma in Mice
    210. What has senescence got to do with cancer?
    211. Targets of AtWRKY6 regulation during plant senescence and pathogen defense
    212. Telomerase, senescence and ageing
    213. Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat.
    214. PML is induced by oncogenic ras and promotes premature senescence
    215. The senescence-Induced Staygreen Protein Regulates Chlorophyll Degradation
    216. Bypass of senescence After Disruption of p21CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts
    217. Differential expression of senescence-associated mRNAs during leaf senescence induced by different senescence-inducing factors in Arabidopsis
    218. Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts.
    219. An attempt to prevent senescence: A mitochondrial approach
    220. Delayed leaf senescence induces extreme drought tolerance in a flowering plant
    221. senescence and Rejuvenation
    222. Forging a signature of in vivo senescence
    223. Evolutionary and Nonevolutionary Theories of senescence
    224. Cellular senescence revisited: a review
    225. Living on a break: cellular senescence as a DNA-damage response
    226. senescence in the whole plant.
    227. Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for senescence?
    228. Geriatric muscle stem cells switch reversible quiescence into senescence
    229. Physiology and molecular biology of petal senescence
    230. Endothelial Cell senescence in Human Atherosclerosis
    231. Telomere positional effects and the regulation of cellular senescence
    232. Role of Ethylene in senescence of Petals—Morphological and Taxonomical Relationships
    233. Paradoxical suppression of cellular senescence by p53
    234. Evidence Supporting a Role of Jasmonic Acid in Arabidopsis Leaf senescence
    235. Prohibitin: Potential role in senescence, development, and tumor suppression
    236. senescence and aging: the critical roles of p53
    237. senescence as a mode of tumor suppression.
    238. Large‐scale identification of leaf senescence‐associated genes
    239. NK and NK/T cells in human senescence
    240. Vascular endothelial senescence: from mechanisms to pathophysiology
    241. Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence.
    242. When cells get stressed: an integrative view of cellular senescence
    243. A mutant with a defect in telomere elongation leads to senescence in yeast
    244. Selenium – an antioxidative protectant in soybean during senescence
    245. Oncogene-Induced senescence: Putting the Brakes on Tumor Development
    246. The power and the promise of oncogene-induced senescence markers
    247. The role of chondrocyte senescence in osteoarthritis
    248. OSTEOPOROSIS : DISEASE OR senescence ?
    249. The pathobiology of Parkinson’s disease: biochemical aspects of dopamine neuron senescence.
    250. A complex secretory program orchestrated by the inflammasome controls paracrine senescence
    251. Growth, Maturation, and senescence in Fruits
    252. ORE9, an F-Box Protein That Regulates Leaf senescence in Arabidopsis
    253. Cell senescence and hypermitogenic arrest
    254. Cellular senescence mediates fibrotic pulmonary disease
    255. Accelerated immune senescence and HIV-1 infection
    256. senescence of leafy vegetables
    257. Mitotic and postmitotic senescence in plants.
    258. NaCl-induced senescence in Leaves of Rice (Oryza sativaL.) Cultivars Differing in Salinity Resistance
    259. Erosion of the telomeric single-strand overhang at replicative senescence
    260. Mechanisms of cellular senescence in human and mouse cells
    261. Loss of ‘Complexity’ and AgingPotential Applications of Fractals and Chaos Theory to senescence
    262. Id proteins in cell cycle control and cellular senescence
    263. A role for both RB and p53 in the regulation of human cellular senescence
    264. Physiological significance of anthocyanins during autumnal leaf senescence
    265. Lamin B1 loss is a senescence-associated biomarker
    266. Isolation and Identification of a senescence-promoting Substance from Wormwood (Artemisia absinthium L.)
    267. Oxidative stress and antioxidant activity as the basis of senescence in maize leaves
    268. Nutrients mobilized from leaves of Arabidopsis thaliana during leaf senescence
    269. Ethylene in Plant Growth, Development, and senescence
    270. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes
    271. Ras Proteins Induce senescence by Altering the Intracellular Levels of Reactive Oxygen Species
    272. Flower senescence in daylily (Hemerocallis)
    273. Role of Oxidative Stress in Telomere Length Regulation and Replicative senescence
    274. Leaf senescence: Correlated with Increased Levels of Membrane Permeability and Lipid Peroxidation, and Decreased Levels of Superoxide Dismutase and Catalase
    275. Deletion of Ku86 causes early onset of senescence in mice
    276. senescence, apoptosis and therapy — cutting the lifelines of cancer
    277. Cellular senescence: A Translational Perspective
    278. senescence-accelerated mouse (SAM): a biogerontological resource in aging research
    279. The timing of maize leaf senescence and characterisation of senescence‐related cDNAs
    280. Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence
    281. Human melanocyte senescence and melanoma susceptibility genes
    282. UV-C treatment delays postharvest senescence in broccoli florets
    283. Processes and control of plant senescence.
    284. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
    285. Pollination-induced flower senescence: a review
    286. Structure elucidation of a senescence cross-link from human extracellular matrix. Implication of pentoses in the aging process.
    287. Oncogene-Induced Cell senescence — Halting on the Road to Cancer
    288. Mitochondrial Dysfunction Contributes to Oncogene-Induced senescence
    289. Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence
    290. Cell cycle arrest is not senescence
    291. Proteolytic activity during senescence of plants
    292. senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
    293. senescence IN NATURAL POPULATIONS OF MAMMALS: A COMPARATIVE STUDY
    294. Grading score system: A method for evaluation of the degree of senescence in senescence Accelerated Mouse (SAM)
    295. Oncogenic ras and p53 Cooperate To Induce Cellular senescence
    296. senescence, Abscission and Cellulase Activity in Phaseolus vulgaris
    297. Oncogenic BRAF Induces senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7
    298. Early Immune senescence in HIV Disease
    299. The role of senescence and immortalization in carcinogenesis
    300. Leaf senescence: Signals, Execution, and Regulation
    301. Cellular senescence and chromatin structure
    302. Cellular senescence in vivo: a barrier to tumorigenesis
    303. Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells,
    304. The shaping of senescence in the wild
    305. Molecular Dissection of Formation of senescence-Associated Heterochromatin Foci
    306. Short Telomeres Limit Tumor Progression In Vivo by Inducing senescence
    307. Zeb1 links epithelial-mesenchymal transition and cellular senescence
    308. Cellular senescence controls fibrosis in wound healing
    309. Jasmonates: Hormonal regulators or stress factors in leaf senescence?
    310. Effect of extrinsic mortality on the evolution of senescence in guppies
    311. Replicative senescence and Oxidant‐Induced Premature senescence: Beyond the Control of Cell Cycle Checkpoints
    312. Mitochondrial Dysfunction Accounts for the Stochastic Heterogeneity in Telomere-Dependent senescence
    313. Immunologic Deficiencies in senescence
    314. Telomeres and senescence: The history, the experiment, the future
    315. A senescence Program Controlled by p53 and p16INK4a Contributes to the Outcome of Cancer Therapy
    316. senescence As an Anticancer Mechanism
    317. Changes in antioxidative enzymes in cucumber cotyledons during natural senescence: comparison with those during dark‐induced senescence
    318. senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells
    319. MicroRNA 217 Modulates Endothelial Cell senescence via Silent Information Regulator 1
    320. The Role of Cellular senescence in Skin Aging
    321. Identification of three genetic loci controlling leaf senescence in Arabidopsis thaliana
    322. Pathobiology of the senescence-accelerated mouse (SAM)
    323. Biochemistry of senescence
    324. Optimization of edible coating composition to retard strawberry fruit senescence
    325. Population cycles in microtines: The senescence hypothesis
    326. Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion?
    327. In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs
    328. Mitochondria: are they the seat of senescence?
    329. senescence of red blood cells: progress and problems
    330. Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis.
    331. T cell senescence.
    332. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
    333. Escape from senescence in human diploid fibroblasts induced directly by mutant p53.
    334. senescence, ageing and death of the whole plant
    335. Reactive Oxygen Species as Mediators of Cellular senescence
    336. TAp63 induces senescence and suppresses tumorigenesis in vivo
    337. p53, ROS and senescence in the control of aging
    338. Cellular senescence in aging and age-related disease: from mechanisms to therapy
    339. Cellular senescence: hot or what?
    340. Microglial senescence: does the brain’s immune system have an expiration date?
    341. A genetic analysis of senescence in Drosophila
    342. Non‐destructive optical detection of pigment changes during leaf senescence and fruit ripening
    343. Role of CMV in immune senescence
    344. JunD Protects Cells from p53-Dependent senescence and Apoptosis
    345. MORPHOLOGIC CHANGES ACCOMPANYING senescence OF CULTURED HUMAN DIPLOID CELLS
    346. Quantitative assessment of markers for cell senescence
    347. Caspase inhibition switches doxorubicin-induced apoptosis to senescence
    348. Replicative senescence of human fibroblast-like cells in culture
    349. Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis
    350. A senescence-associated gene of Arabidopsis thaliana is distinctively regulated during natural and artificially induced leaf senescence
    351. Impact of cellular senescence signature on ageing research
    352. DNA damage response and cellular senescence in tissues of aging mice
    353. Lack of Replicative senescence in Normal Rodent Glia
    354. Peroxisome senescence in Human Fibroblasts
    355. Effects of estrogen on growth plate senescence and epiphyseal fusion
    356. DNA damage, cellular senescence and organismal ageing: causal or correlative?
    357. Lack of Replicative senescence in Cultured Rat Oligodendrocyte Precursor Cells
    358. Human Platelet senescence
    359. Feedback between p21 and reactive oxygen production is necessary for cell senescence
    360. Oncogene-Induced senescence Pathways Weave an Intricate Tapestry
    361. A Role for Diacylglycerol Acyltransferase during Leaf senescence
    362. senescence-induced RNases in tomato
    363. Identification of a transcription factor specifically expressed at the onset of leaf senescence
    364. PRAK Is Essential for ras-Induced senescence and Tumor Suppression
    365. Relation between leaf senescence and stomatal closure: senescence in light
    366. Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I—effects of proliferative senescence
    367. Total body irradiation selectively induces murine hematopoietic stem cell senescence
    368. Is Petal senescence Due to Sugar Starvation?
    369. senescence and apoptosis: dueling or complementary cell fates?
    370. Cellular senescence as a tumor-protection mechanism: the essential role of counting
    371. AtNAP, a NAC family transcription factor, has an important role in leaf senescence
    372. Metabolism of Oat Leaves during senescence
      V. senescence in Light
    373. Leaf senescence in rice plants: cloning and characterization of senescence up‐regulated genes
    374. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
    375. Memory T cell homeostasis and senescence during aging
    376. Natal dispersal and senescence
    377. Cell wall metabolism during maturation, ripening and senescence of peach fruit
    378. senescence, sleep, and circadian rhythms
    379. Neurologic Signs in senescence
    380. Genetic regulation of embryo death and senescence
    381. Lysosome-mediated processing of chromatin in senescence
    382. The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence
    383. senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning
    384. Inside and out: the activities of senescence in cancer
    385. p16Ink4a in Melanocyte senescence and Differentiation
    386. Replicative senescence of human endothelial cells in vitro involves G1 arrest, polyploidization and senescence-associated apoptosis
    387. Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas
    388. Autophagy facilitates oncogene-induced senescence
    389. Cellular senescence: A link between cancer and age-related degenerative disease?
    390. senescence‐associated intrinsic mechanisms of osteoblast dysfunctions
    391. Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer
    392. Secretion of Vascular Endothelial Growth Factor by Primary Human Fibroblasts at senescence
    393. Transcription factors regulating leaf senescence in Arabidopsis thaliana
    394. Expression of senescence‐enhanced genes in response to oxidative stress
    395. A Phylogenetic Evaluation of Whether Endophytes Become Saprotrophs at Host senescence
    396. Mitochondria, telomeres and cell senescence
    397. Mechanisms, Functional Consequences, and Potential Therapeutics for Cellular senescence
    398. Evidence for programmed cell death during leaf senescence in plants [1998]
    399. senescence: a new weapon for cancer therapy
    400. Ethylene Production During senescence of Flowers
    401. Die and let live: leaf senescence contributes to plant survival under drought stress
    402. Astrocyte senescence as a Component of Alzheimer’s Disease
    403. Alcohols and Carnation senescence
    404. AGE‐SPECIFIC SURVIVAL IN FIVE POPULATIONS OF UNGULATES: EVIDENCE OF senescence
    405. Fibroblast senescence in pressure ulcers
    406. Mental efficiency in senescence.
    407. Chloroplasts regulate leaf senescence: delayed senescence in transgenic ndhF-defective tobacco
    408. Retarded senescence in an insular population of Virginia opossums (Didelphis virginiana)
    409. Ink4a/Arf links senescence and aging
    410. Retardation of radish leaf senescence by polyamines
    411. Salicylic acid has a role in regulating gene expression during leaf senescence
    412. DNA Damage Is Able to Induce senescence in Tumor Cells in Vitro and in Vivo
    413. Hormone receptor changes during adulthood and senescence: significance for aging research.
    414. Vascular smooth muscle cell senescence in atherosclerosis
    415. How might replicative senescence contribute to human ageing?
    416. Age-related changes in learning and memory in the senescence-accelerated mouse (SAM)
    417. Angiotensin II accelerates endothelial progenitor cell senescence through induction of oxidative stress
    418. INDIVIDUAL DIFFERENCES, LONGEVITY, AND REPRODUCTIVE senescence IN BIGHORN EWES
    419. DNA damage checkpoint kinase Chk2 triggers replicative senescence
    420. Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and senescence
    421. Targets of the WRKY53 transcription factor and its role during leaf senescence in Arabidopsis
    422. Reversal of senescence in Mouse Fibroblasts through Lentiviral Suppression of p53
    423. senescence‐associated proteases in plants
    424. Cigarette Smoke Induces senescence in Alveolar Epithelial Cells
    425. senescence-Associated Exosome Release from Human Prostate Cancer Cells
    426. Aging and Cancer: The Double‐Edged Sword of Replicative senescence
    427. The evolution of premature reproductive senescence and menopause in human females
    428. senescence of an Antibody-forming Cell Clone
    429. miR-22 represses cancer progression by inducing cellular senescence
    430. Telomerase Inhibition, Telomere Shortening, and senescence of Cancer Cells by Tea Catechins
    431. cGAS is essential for cellular senescence
    432. Effect of Kinetin on Protein & Nucleic Acid Metabolism in Xanthium Leaves During senescence
    433. A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
    434. Retardation of the senescence of Cultured Human Diploid Fibroblasts by Carnosine
    435. Plant senescence
    436. Immune Activation and CD8+ T-Cell Differentiation towards senescence in HIV-1 Infection
    437. Telomere Shortening Triggers senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a
    438. Mitogen‐activated protein kinase p38 defines the common senescence‐signalling pathway
    439. Werner syndrome protein limits MYC-induced cellular senescence
    440. Identification of senescence-associated genes from daylily petals
    441. Cellular senescence in naevi and immortalisation in melanoma: a role for p16?
    442. Leaf senescence and nutrient remobilisation in barley and wheat
    443. Stay-green regulates chlorophyll and chlorophyll-binding protein degradation during senescence
    444. Overcoming cellular senescence in human cancer pathogenesis
    445. The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing
    446. PHOTOCONTROL OF LEAF senescence
    447. Hallmarks of Cellular senescence
    448. Inhibition of p21‐mediated ROS accumulation can rescue p21‐induced senescence
    449. Vascular cell senescence and vascular aging
    450. The p16INK4a-RB pathway : molecular link between cellular senescence and tumor suppression
    451. T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment
    452. Loss of linker histone H1 in cellular senescence
    453. Fibroblasts cultured from venous ulcers display cellular characteristics of senescence
    454. senescence and programmed cell death: substance or semantics?
    455. Rapid induction of senescence in human cervical carcinoma cells
    456. Networking senescence-Regulating Pathways by Using Arabidopsis Enhancer Trap Lines
    457. Synthetic lethal metabolic targeting of cellular senescence in cancer therapy
    458. DOES INCREASED MORTALITY FAVOR THE EVOLUTION OF MORE RAPID senescence?
    459. Relation between senescence and stomatal opening: senescence in darkness
    460. Measuring senescence in wild animal populations: towards a longitudinal approach
    461. Cell senescence in the Aging Kidney
    462. p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC
    463. Replicative senescence and Cell Immortality: The Role of Telomeres and Telomerase
    464. Cellular senescence, ageing and disease
    465. Effect of sugar-induced senescence on gene expression and implications for the regulation of senescence in Arabidopsis
    466. Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis
    467. Victorin Induction of an Apoptotic/senescence–like Response in Oats
    468. The oxidative hypothesis of senescence
    469. Accumulation of Short Telomeres in Human Fibroblasts Prior to Replicative senescence
    470. Stress-induced Premature senescence (SIPS)
    471. Significant Role for p16INK4a in p53-Independent Telomere-Directed senescence
    472. Is β-Galactosidase Staining a Marker of senescence in Vitro and in Vivo?
    473. Role of polyamines and ethylene as modulators of plant senescence
    474. Aging and Immortality: Quasi-Programmed senescence and Its Pharmacologic Inhibition
    475. Ovarian Dynamics in Heliconiine Butterflies: Programmed senescence versus Eternal Youth
    476. Inflammatory signaling and cellular senescence
    477. PROTEIN SYNTHESIS AND DEGRADATION DURING AGING AND senescence
    478. Extracellular Invertase Is an Essential Component of Cytokinin-Mediated Delay of senescence
    479. Physical activity and immune senescence in men.
    480. Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence
    481. Mitochondrial Dysfunction Induces senescence with a Distinct Secretory Phenotype
    482. Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast
    483. Regulation of mitochondrial respiration in senescence
    484. Induction of EMT by Twist Proteins as a Collateral Effect of Tumor-Promoting Inactivation of Premature senescence
    485. Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced senescence
    486. Role of Cytokinins in Carnation Flower senescence
    487. Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes
    488. The roles of senescence and telomere shortening in cardiovascular disease
    489. Vertical saccades in senescence.
    490. Variations in senescence and Longevity Include the Possibility of Negligible senescence
    491. Lipid turnover during senescence
    492. Mechanisms of endothelial senescence
    493. Natural senescence of Pea Leaves (An Activated Oxygen-Mediated Function for Peroxisomes)
    494. Water Stress during Seed Filling and Leaf senescence in Soybean
    495. Stress-induced premature senescence and tissue ageing
    496. Increase of deleted mitochondrial DNA in the striatum in Parkinson’s disease and senescence
    497. Defining cellular senescence in IMR-90 cells: a flow cytometric analysis
    498. Cellular senescence mechanisms in chronic wound healing
    499. Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation
    500. The role of CD8+ T‐cell replicative senescence in human aging
    501. Telomere Erosion and senescence in Human Articular Cartilage Chondrocytes
    502. Cellular senescence and DNA synthesis: Thymidine incorporation as a measure of population age in human diploid cells
    503. A Novel Role for High-Mobility Group A Proteins in Cellular senescence and Heterochromatin Formation
    504. Healing and Hurting: Molecular Mechanisms, Functions, and Pathologies of Cellular senescence
    505. Signal transduction in leaf senescence
    506. senescence in seeds.
    507. Growth stimulation leads to cellular senescence when the cell cycle is blocked
    508. Epidermal differentiation, apoptosis, and senescence: common pathways?
    509. Cellular senescence in the glaucomatous outflow pathway
    510. Leaf senescence Is Delayed in Tobacco Plants Expressing the Maize Homeobox Gene knotted1 under the Control of a senescence-Activated Promoter
    511. Induction of cellular senescence in immortalized cells by human chromosome 1
    512. senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells
    513. Stabilization of Oat Leaf Protoplasts through Polyamine-mediated Inhibition of senescence
    514. Androgens in male senescence
    515. Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4a
    516. Mitogenic signalling and the p16INK4a–Rb pathway cooperate to enforce irreversible cellular senescence
    517. Programmed Cell Death during Pollination-Induced Petal senescence in Petunia
    518. Developmental and age-related processes that influence the longevity and senescence of photosynthetic tissues in arabidopsis.
    519. Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?
    520. Reactive oxygen species and oxidative burst: Roles in stress, senescence and signal transducation in plants
    521. Molecular and Biochemical Characterization of Postharvest senescence in Broccoli
    522. TWIN STUDIES ON senescence
    523. senescence of the Human Immune System
    524. Longevity and senescence in plants
    525. senescence‐specific regulation of catalases in Arabidopsis thaliana (L.) Heynh
    526. Extended culture of mouse embryo cells without senescence: inhibition by serum
    527. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes
    528. Desiccation, Flight, Glycogen, and Postponed senescence in Drosophila metanogaster
    529. Klotho as a regulator of oxidative stress and senescence
    530. Twisted epithelial–mesenchymal transition blocks senescence
    531. BENZYLADENINE EFFFCTS ON BEAN LEAF GROWTH AND senescence
    532. The Strategy of senescence
    533. Differences in gene expression between natural and artificially induced leaf senescence
    534. Aging and Replicative senescence Have Related Effects on Human Stem and Progenitor Cells
    535. Requirement for p27KIP1 in Retinoblastoma Protein-Mediated senescence
    536. Replicative senescence in Human Uroepithelial Cells
    537. MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
    538. Superoxide Dismutase 1 Knock-down Induces senescence in Human Fibroblasts
    539. Cellular senescence in vivo: Its relevance in ageing and cardiovascular disease
    540. Evolutionary Perspectives on Human senescence
    541. T Cell Replicative senescence in Human Aging
    542. Possible Mechanisms of Adaptive Leaf senescence
    543. Sorghum stay-green QTL individually reduce post-flowering drought-induced leaf senescence
    544. senescence Mutants of Saccharomyces cerevisiae With a Defect in Telomere Replication Identify Three Additional EST Genes
    545. senescence AND REPRODUCTIVE VALUE IN SPARROWHAWKS
    546. Understanding insect life histories and senescence through a resource allocation lens
    547. Klotho suppresses RIG-I-mediated senescence-associated inflammation
    548. Cardiac Muscle Changes in senescence
    549. Ethylene as a Regulator of senescence in Tobacco Leaf Discs
    550. Aspirin reduces endothelial cell senescence
    551. senescence IN NATURAL POPULATIONS OF MAMMALS: A REANALYSIS
    552. Growth and senescence of antibody‐forming cells
    553. Regulation of a senescence Checkpoint Response by the E2F1 Transcription Factor and p14ARF Tumor Suppressor
    554. INK4a-de®cient human diploid ®broblasts areresistant to RAS-induced senescence
    555. Response of a primary human fibroblast cell line to H2O2: senescence-like growth arrest or apoptosis?
    556. A senescence-like Phenotype Distinguishes Tumor Cells That Undergo Terminal Proliferation Arrest after Exposure to Anticancer Agents
    557. Cdk2 suppresses cellular senescence induced by the c-myc oncogene
    558. Identification of a promoter region responsible for the senescence-specific expression of SAG12
    559. Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix
    560. ANTAGONISTIC PLEIOTROPY, MORTALITY SOURCE INTERACTIONS, AND THE EVOLUTIONARY THEORY OF senescence
    561. Wound chronicity and fibroblast senescence – implications for treatment
    562. Insect thermal tolerance: what is the role of ontogeny, ageing and senescence?
    563. THE CORRELATION BETWEEN OXIDATIVE STRESS AND LEAF senescence DURING PLANT DEVELOPMENT #
    564. p38MAPK is a novel DNA damage response‐independent regulator of the senescence‐associated secretory phenotype
    565. Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells
    566. Effect of Pod Removal on Leaf senescence in Soybeans
    567. On the senescence of ovules in cherries
    568. OsNAP connects abscisic acid and leaf senescence by fine-tuning abscisic acid biosynthesis and directly targeting senescence-associated genes in rice
    569. Acceleration of senescence in the collared flycatcher Ficedula albicollis by reproductive costs
    570. Rapid and costly ageing in wild male flies
    571. Transcription Analysis of Arabidopsis Membrane Transporters and Hormone Pathways during Developmental and Induced Leaf senescence
    572. Role of p14ARF in Replicative and Induced senescence of Human Fibroblasts
    573. Leaf senescence and Starvation-Induced Chlorosis Are Accelerated by the Disruption of an Arabidopsis Autophagy Gene
    574. The Role of Protein Synthesis in the senescence of Leaves
    575. Emergence, Elongation, and senescence of Maize Silks
    576. Hemangioblastic Derivatives from Human Induced Pluripotent Stem Cells Exhibit Limited Expansion and Early senescence
    577. Immune senescence
    578. Glucose-Induced Replicative senescence in Mesenchymal Stem Cells
    579. p63 deficiency activates a program of cellular senescence and leads to accelerated aging
    580. Weak p53 permits senescence during cell cycle arrest
    581. Aging and sensory senescence.
    582. Pathways connecting telomeres and p53 in senescence, apoptosis, and cancer
    583. Tumour suppression by p53: the importance of apoptosis and cellular senescence
    584. Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells
    585. Does a Sentinel or a Subset of Short Telomeres Determine Replicative senescence?
    586. Markers for hypersensitive response and senescence show distinct patterns of expression
    587. The role of nuclear lamin B1 in cell proliferation and senescence
    588. Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis
    589. Post‐traumatic osteoarthritis: The role of accelerated chondrocyte senescence
    590. senescence and the healing rates of venous ulcers
    591. The senescence‐Related Mitochondrial/Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem Cells
    592. senescence and Receptivity of Maize Silks
    593. Molecular signature of oncogenic ras-induced senescence
    594. senescence and Embedded-Figure Performance in Vision and Touch
    595. Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells
    596. Role of calcium in ripening and senescence
    597. Pheophytin Pheophorbide Hydrolase (Pheophytinase) Is Involved in Chlorophyll Breakdown during Leaf senescence in Arabidopsis
    598. Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence
    599. Id-1 Delays senescence but Does Not Immortalize Keratinocytes
    600. Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular senescence
    601. Cellular aging and senescence
    602. Mitochondrial production of pro-oxidants and cellular senescence
    603. p16INK4a can initiate an autonomous senescence program
    604. Genetic analysis of cellular senescence
    605. A comparison of the expression patterns of several senescence-associated genes in response to stress and hormone treatment
    606. Replicative senescence Revisited
    607. Evolution of accelerated senescence in laboratory populations of Drosophila
    608. Cytoplasmic chromatin triggers inflammation in senescence and cancer
    609. Hormone-directed Transport of Metabolites and its possible Role in Plant senescence
    610. The evolution of senescence in fish
    611. senescence‐associated lncRNAs: senescence‐associated long noncoding RNAs
    612. Regulation of Leaf senescence by Cytokinin, Sugars, and Light
    613. Cellular senescence in the pathogenesis of benign prostatic hyperplasia
    614. A causal link between respiration and senescence in Podospora anserina
    615. Early Compositional Changes during Postharvest senescence of Broccoli
    616. HDA6 is required for jasmonate response, senescence and flowering in Arabidopsis
    617. Arabidopsis Cytokinin Receptor Mutants Reveal Functions in Shoot Growth, Leaf senescence, Seed Size, Germination, Root Development, and Cytokinin Metabolism
    618. Leaf senescence and activities of the antioxidant enzymes
    619. Cellular senescence drives age-dependent hepatic steatosis
    620. Cloning and characterization of tomato leaf senescence-related cDNAs
    621. Role of Telomerase in Cell senescence and Oncogenesis
    622. Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands
    623. senescence in fishes
    624. Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways
    625. CD28 extinction in human T cells: altered functions and the program of T‐cell senescence
    626. Mitochondrial Dysfunction in the senescence Accelerated Mouse (SAM)
    627. Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts
    628. Adriamycin-induced senescence in Breast Tumor Cells Involves Functional p53 and Telomere Dysfunction
    629. MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8
    630. senescence in natural populations of animals: Widespread evidence and its implications for bio-gerontology
    631. Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence.
    632. The Control of Autumn senescence in European Aspen
    633. Genetic regulation of primitive hematopoietic stem cell senescence
    634. DNA fragmentation is regulated by ethylene during carpel senescence in Pisum sativum
    635. AUXIN RESPONSE FACTOR1 and AUXIN RESPONSE FACTOR2 regulate senescence and floral organ abscission in Arabidopsis thaliana
    636. p63–microRNA feedback in keratinocyte senescence
    637. Role of the Ascorbate-Glutathione Cycle of Mitochondria and Peroxisomes in the senescence of Pea Leaves
    638. Effects of PSAG12-IPT Gene Expression on Development and senescence in Transgenic Lettuce
    639. Involvement of free radicals in ageing: a consequence or cause of senescence
    640. The Remobilization of Nitrogen Related to Leaf Growth and senescence in Rice Plants (Oryza sativa L.)
    641. NF-κB inhibition delays DNA damage–induced senescence and aging in mice
    642. Decreased beta-adrenergic responsiveness during senescence.
    643. Membrane phospholipid catabolism and Ca2+ activity in control of senescence
    644. Mechanism of Monocarpic senescence in Rice
    645. Oxidative stress occurs during soybean nodule senescence
    646. Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence.
    647. Longevity and the genetic determination of collagen glycoxidation kinetics in mammalian senescence
    648. High levels of antioxidant enzymes correlate with delayed senescence in nonnetted muskmelon fruits
    649. Relationship between Photosynthesis and Chlorophyll Content during Leaf senescence of Rice Seedlings
    650. The Role of Ethylene in the senescence of Oat Leaves
    651. Splicing into senescence: The Curious Case of p16 and p19ARF
    652. The Gene Expression Program of Prostate Fibroblast senescence Modulates Neoplastic Epithelial Cell Proliferation through Paracrine Mechanisms
    653. Cellular senescence and chromatin organisation
    654. Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53
    655. Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence
    656. DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?
    657. Ageing, telomeres, senescence, and liver injury
    658. Evidence That Aging And Amyloid Promote Microglial Cell senescence
    659. Cellular senescence and DNA repair
    660. Rethinking the evolutionary theory of aging: Transfers, not births, shape senescence in social species
    661. Vascular Smooth Muscle Cells Undergo Telomere-Based senescence in Human Atherosclerosis
    662. Assessing Cell and Organ senescence Biomarkers
    663. Molecular Regulation of Melanocyte senescence
    664. Premature senescence of endothelial cells: Methusaleh’s dilemma
    665. Resistance to Environmental Stress in Drosophila melanogaster Selected for Postponed senescence
    666. Oxidative stress induces senescence in chondrocytes
    667. p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence
    668. HIF1α delays premature senescence through the activation of MIF
    669. Retardation of leaf senescence by benzyladenine in intact bean plants
    670. Cellular senescence and the aging brain
    671. Carnosine as a Potential Anti-senescence Drug
    672. The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15Ink4b
    673. Cellular aging–clonal senescence. A review (Part I)
    674. Is Accelerated senescence a Cost of Reproduction?
    675. Astrocytes in the aging brain express characteristics of senescence‐associated secretory phenotype
    676. MicroRNAs linking inflamm-aging, cellular senescence and cancer
    677. senescence-associated inflammatory responses: aging and cancer perspectives
    678. Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53‐dependent cellular senescence
    679. Altered fruit ripening and leaf senescence in tomatoes expressing an antisense ethylene‐forming enzyme transgene
    680. Antioxidants Inhibit Nuclear Export of Telomerase Reverse Transcriptase and Delay Replicative senescence of Endothelial Cells
    681. The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4
    682. Evidence that exposure of the telomere 3′ overhang sequence induces senescence
    683. Physiological compensation for loss of afferent synapses in rat hippocampal granule cells during senescence.
    684. Ribulose Bisphosphate Carboxylase and Proteolytic Activity in Wheat Leaves from Anthesis through senescence
    685. Spontaneous age-associated amyloidosis in senescence-accelerated mouse (SAM)
    686. Cellular senescence: Molecular Mechanisms, In Vivo Significance, and Redox Considerations
    687. Overexpression of Arabidopsis Hexokinase in Tomato Plants Inhibits Growth, Reduces Photosynthesis, and Induces Rapid senescence
    688. senescence induction; a possible cancer therapy
    689. Cell senescence and Its Implications for Nephrology
    690. Accelerated senescence: An emerging role in tumor cell response to chemotherapy and radiation
    691. Central Role of the Proteasome in senescence and Survival of Human Fibroblasts
      INDUCTION OF A senescence-LIKE PHENOTYPE UPON ITS INHIBITION AND RESISTANCE TO STRESS UPON ITS ACTIVATION
    692. Differential Roles for Cyclin-Dependent Kinase Inhibitors p21 and p16 in the Mechanisms of senescence and Differentiation in Human Fibroblasts
    693. senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts.
    694. Characteristics of age-related behavioral changes in senescence-accelerated mouse SAMP8 and SAMP10
    695. Mammalian Prohibitin Proteins Respond to Mitochondrial Stress and Decrease during Cellular senescence
    696. Antisense suppression of phospholipase D alpha retards abscisic acid- and ethylene-promoted senescence of postharvest Arabidopsis leaves.
    697. Autophagy, senescence and tumor dormancy in cancer therapy
    698. senescence of immune defence in Bombus workers
    699. senescence-Induced Serotonin Biosynthesis and Its Role in Delaying senescence in Rice Leaves
    700. Role of T lymphocyte replicative senescence in vaccine efficacy
    701. Dental senescence in a long-lived primate links infant survival to rainfall
    702. The influence of sward condition on rates of herbage growth and senescence in mixed swards under continuous stocking management
    703. Cytokinin Activity in Rose Petals and Its Relation to senescence
    704. Evidence for Multiple Pathways to Cellular senescence
    705. Arabidopsis Nitric Oxide Synthase1 Is Targeted to Mitochondria and Protects against Oxidative Damage and Dark-Induced senescence
    706. Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and senescence in Neuroblastoma
    707. Cellular senescence in cancer treatment: friend or foe?
    708. Human chondrocyte senescence and osteoarthritis
    709. Spectral Reflectance Changes Associated with Autumn senescence of Aesculus hippocastanum L. and Acer platanoides L. Leaves. Spectral Features and Relation to Chlorophyll Estimation
    710. BULB-TYPE FLOWER senescence
    711. Pathway analysis of senescence-associated miRNA targets reveals common processes to different senescence induction mechanisms
    712. Protein oxidation and degradation during postmitotic senescence
    713. Doubling potential, calendar time, and senescence of human diploid cells in culture
    714. Inflammatory bowel disease-like enteritis and caecitis in a senescence accelerated mouse P1/Yit strain
    715. Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis
    716. mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
    717. senescence Is Induced in Individually Darkened Arabidopsis Leaves, but Inhibited in Whole Darkened Plants
    718. Hypoxia suppresses conversion from proliferative arrest to cellular senescence
    719. RNS2: a senescence-associated RNase of Arabidopsis that diverged from the S-RNases before speciation
    720. Interleukin‐22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice
    721. Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts
    722. Evolutionary Biology of senescence
    723. Eating to exit: autophagy-enabled senescence revealed
    724. Loss of CD28 expression on T lymphocytes: A marker of replicative senescence
    725. senescence‐associated vacuoles with intense proteolytic activity develop in leaves of Arabidopsis and soybean
    726. senescence-associated beta-galactosidase histochemistry for the primate eye.
    727. Cytokine loops driving senescence
    728. MicroRegulators come of age in senescence
    729. DNA end joining becomes less efficient and more error-prone during cellular senescence
    730. Conditional senescence in bacteria: death of the immortals
    731. senescence and Death of Primitive Cells and Myocytes Lead to Premature Cardiac Aging and Heart Failure
    732. Isolation and analysis of cDNAs encoding tomato cysteine proteases expressed during leaf senescence
    733. Negligible senescence in the longest living rodent, the naked mole-rat: insights from a successfully aging species
    734. Mate Choice, Sexual Conflict, and Evolution of senescence
    735. Markers of cellular senescence. Telomere shortening as a marker of cellular senescence
    736. Stress-Induced Legume Root Nodule senescence. Physiological, Biochemical, and Structural Alterations
    737. Chlorophyll b reduction during senescence of barley seedlings
    738. Categories of Petal senescence and Abscission: A Re-evaluation
    739. Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a senescence-like Arrest Mediated by p27Kip1
    740. Relation between Nitrogen and Ribulose-1,5-bisphosphate Carboxylase in Rice Leaves from Emergence through senescence
    741. ETHYLENE-INSENSITIVE3 Is a senescence-Associated Gene That Accelerates Age-Dependent Leaf senescence by Directly Repressing miR164 Transcription in Arabidopsis
    742. TP53 and MTOR crosstalk to regulate cellular senescence
    743. senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans
    744. Physiological and pathological consequences of cellular senescence
    745. Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts
    746. senescence from G2 arrest, revisited
    747. ORS1, an H2O2-Responsive NAC Transcription Factor, Controls senescence in Arabidopsis thaliana
    748. THE KINETICS OF senescence
    749. Arbuscular mycorrhizal symbiosis can alleviate drought‐induced nodule senescence in soybean plants
    750. High-Resolution Temporal Profiling of Transcripts during Arabidopsis Leaf senescence Reveals a Distinct Chronology of Processes and Regulation
    751. The evolution of senescence from a comparative perspective
    752. Relationship between Ethylene Evolution and senescence in Morning-Glory Flower Tissue
    753. WRKY22 transcription factor mediates dark-induced leaf senescence in Arabidopsis
    754. senescence of nickel-transformed cells by an X chromosome: possible epigenetic control
    755. Hydrogen sulfide acts as a regulator of flower senescence in plants
    756. Gene expression during anthesis and senescence in Iris flowers
    757. Induced senescence of Intact Wheat Seedlings and Its Reversibility
    758. Oncogene-induced senescence: the bright and dark side of the response
    759. miR-29 and miR-30 regulate B-Myb expression during cellular senescence
    760. Negligible senescence during Reproductive Dormancy in Drosophila melanogaster
    761. Delayed Leaf senescence in Tobacco Plants Transformed with tmr, a Gene for Cytokinin Production in Agrobacterium.
    762. Monitoring Tumorigenesis and senescence In Vivo with a p16INK4a-Luciferase Model
    763. Endothelial Cell senescence
    764. Hormonal changes during salinity-induced leaf senescence in tomato (Solanum lycopersicum L.)
    765. Short Periods of Water Stress during Seed Filling, Leaf senescence, and Yield of Soybean
    766. senescence, nutrient remobilization, and yield in wheat and barley
    767. senescence and the Genetic-Correlation Hang-Up
    768. REVIEW ARTICLE. p53: GUARDIAN OF CELLULAR senescence
    769. Phospholipase D in cellular senescence
    770. Rice NON-YELLOW COLORING1 Is Involved in Light-Harvesting Complex II and Grana Degradation during Leaf senescence
    771. Delayed leaf senescence in ethylene‐deficient ACC‐oxidase antisense tomato plants: molecular and physiological analysis
    772. Source : sink ratio and leaf senescence in maize:: I. Dry matter accumulation and partitioning during grain filling
    773. Carotenoid catabolism during leaf senescence and its control by light
    774. senescence: does it all happen at the ends?
    775. Oxidative stress induces senescence in human mesenchymal stem cells
    776. DNA damage, vascular senescence and atherosclerosis
    777. Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration
    778. DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion
    779. Role of p21 in Apoptosis and senescence of Human Colon Cancer Cells Treated with Camptothecin
    780. Oxygen free radicals in cell senescence: Are they signal transducers?
    781. Genetics of cellular senescence
    782. Regulation of E2Fs and senescence by PML nuclear bodies
    783. Cellular senescence and cancer chemotherapy resistance
    784. RNA Interference of Human Papillomavirus Type 18 E6 and E7 Induces senescence in HeLa Cells
    785. senescence and immortality in hepatocellular carcinoma
    786. senescence Processes in Leaf Abscission
    787. Acceleration of Membrane senescence in Cut Carnation Flowers by Treatment with Ethylene
    788. Oncogenic functions of tumour suppressor p21Waf1/Cip1/Sdi1: association with cell senescence and tumour-promoting activities of stromal fibroblasts
    789. WRKY54 and WRKY70 co-operate as negative regulators of leaf senescence in Arabidopsis thaliana
    790. Calcium regulation of senescence in rose petals
    791. Leaf senescence in Brassica napus: expression of genes encoding pathogenesis-related proteins
    792. Leaf senescence in maize hybrids: plant population, row spacing and kernel set effects
    793. The Effects of Ear Removal on senescence and Metabolism of Maize
    794. Time, telomeres and tumours: is cellular senescence more than an anticancer mechanism?
    795. Asexual metazoans undergo senescence.
    796. The biochemistry and regulation of senescence in chloroplasts
    797. Catalase and Peroxidase in Primary Bean Leavesduring Development and senescence
    798. Correlation of Xylem Sap Cytokinin Levels with Monocarpic senescence in Soybean
    799. Induction of senescence by oncogenic ras
    800. Mechanisms of polyamine action during senescence responses induced by osmotic stress
    801. Papillomavirus E2 induces senescence in HPV‐positive cells via pRB‐ and p21CIP‐dependent pathways
    802. Role of Ethylene in the senescence of Detached Rice Leaves
    803. senescence, Stress, and Reactive Oxygen Species
    804. A Role for Glutamine Synthetase in the Remobilization of Leaf Nitrogen during Natural senescence in Rice Leaves
    805. Predatory senescence in ageing wolves
    806. Hydrogen Sulfide Protects Against Cellular senescence via S-Sulfhydration of Keap1 and Activation of Nrf2
    807. Estrogen reduces endothelial progenitor cell senescence through augmentation of telomerase activity
    808. ABA receptor PYL9 promotes drought resistance and leaf senescence
    809. senescence-associated reprogramming promotes cancer stemness
    810. Arabidopsis AtNAP regulates fruit senescence
    811. Reversible senescence in Human CD4+CD45RA+CD27− Memory
    812. T Cell Activation and senescence Predict Subclinical Carotid Artery Disease in HIV-Infected Women
    813. Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition
    814. Evolutionary mechanisms of senescence
    815. Changes in Capsaicinoids during Development, Maturation, and senescence of Chile Peppers and Relation with Peroxidase Activity
    816. The Vacuole and Cell senescence
    817. The role of ubiquitin in plant senescence and stress responses
    818. DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly
    819. Induction of senescence in human malignant glioma cells by p16INK4A
    820. Leaf peroxisomes are directly transformed to glyoxysomes during senescence of pumpkin cotyledons
    821. Convergence and divergence in gene expression profiles induced by leaf senescence and 27 senescence‐promoting hormonal, pathological and environmental stress treatments
    822. senescence mechanisms of nucleus pulposus chondrocytes in human intervertebral discs
    823. Transcriptional regulation of cellular senescence
    824. Molecular and Cell Biology of Replicative senescence
    825. Ethylene-regulated expression of a carnation cysteine proteinase during flower petal senescence
    826. senescence and death of plant organs: Nutrient recycling and developmental regulation
    827. p16Ink4a overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors
    828. Chemokines Acting via CXCR2 and CXCR4 Control the Release of Neutrophils from the Bone Marrow and Their Return following senescence
    829. The senescence of the Immune System
    830. Telomere-driven replicative senescence is a stress response
    831. Methyl Jasmonate, Calcium, and Leaf senescence in Rice
    832. Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras
    833. Smurf2 up-regulation activates telomere-dependent senescence
    834. Autophagy and senescence
    835. Critical pathways in cellular senescence and immortalization revealed by gene expression profiling
    836. The evolutionary ecology of pre- and post-meiotic sperm senescence
    837. Inhibition of phospholipase D by lysophosphatidylethanolamine, a lipid-derived senescence retardant
    838. Chlorophyll-a degradation during cellular senescence and death
    839. Integrated Signaling in Flower senescence
    840. Mechanisms of Disease: role of chondrocytes in the pathogenesis of osteoarthritis—structure, chaos and senescence
    841. Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency
    842. PML interaction with p53 and its role in apoptosis and replicative senescence
    843. Thidiazuron—a potent inhibitor of leaf senescence in Alstroemeria
    844. The disparity between human cell senescence in vitro and lifelong replication in vivo
    845. Ethylene receptor expression is regulated during fruit ripening, flower senescence and abscission
    846. T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infection
    847. Expression of Caveolin-1 Induces Premature Cellular senescence in Primary Cultures of Murine Fibroblasts
    848. A Systematic Screen for CDK4/6 Substrates Links FOXM1 Phosphorylation to senescence Suppression in Cancer Cells
    849. Stress-induced premature senescence and replicative senescence are different phenotypes, proteomic evidence
    850. Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)
    851. Endogenous Human Papillomavirus E6 and E7 Proteins Differentially Regulate Proliferation, senescence, and Apoptosis in HeLa Cervical Carcinoma Cells
    852. Transcriptome analysis of senescence in the flag leaf of wheat (Triticum aestivum L.)
    853. Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-κB
    854. The Relation of Autoǵamy to senescence and Rejuvenescence in Paramecium aurelia
    855. senescence and Genetic Load: Evidence from Tribolium
    856. senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform
    857. Leaf senescence – not just a ‘wear and tear’ phenomenon
    858. Immune senescence: Mechanisms and Clinical Implications
    859. Involvement of the INK4a/Arf gene locus in senescence
    860. Free radical oxidation of brain proteins in accelerated senescence and its modulation by N-tert-butyl-α-phenylnitrone
    861. ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence
    862. Errors in Protein Synthesis and Clonal senescence in Fungi
    863. The E3 SUMO Ligase PIASy Is a Regulator of Cellular senescence and Apoptosis
    864. miRNA-205 Suppresses Melanoma Cell Proliferation and Induces senescence via Regulation of E2F1 Protein
    865. Hidden costs of infection: Chronic malaria accelerates telomere degradation and senescence in wild birds
    866. Replicative senescence of CD8 T cells: effect on human ageing
    867. Studies on Soybean Nodule senescence
    868. Cellular senescence: Its role in tumor suppression and aging
    869. Evidence for the function of the free radical gas — nitric oxide (NO•) — as an endogenous maturation and senescence regulating factor in higher plants
    870. AtATG18a is required for the formation of autophagosomes during nutrient stress and senescence in Arabidopsis thaliana
    871. Propagation and senescence of human marrow stromal cells in culture: a simple colony‐forming assay identifies samples with the greatest potential to propagate and differentiate
    872. senescence Regulation by the p53 Protein Family
    873. Cell surface-bound IL-1α is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network
    874. mTOR Inhibition Prevents Epithelial Stem Cell senescence and Protects from Radiation-Induced Mucositis
    875. Cellular lifespan and senescence signaling in embryonic stem cells
    876. Lung fibroblasts from patients with emphysema show markers of senescence in vitro
    877. Future atmospheric CO2 leads to delayed autumnal senescence
    878. Sugars, senescence, and ageing in plants and heterotrophic organisms
    879. Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation
    880. Mutation and senescence: where genetics and demography meet
    881. miR-200c is upregulated by oxidative stress and induces endothelial cell apoptosis and senescence via ZEB1 inhibition
    882. ATR signaling can drive cells into senescence in the absence of DNA breaks
    883. OPTIMALITY THEORY, GOMPERTZ’ LAW, AND THE DISPOSABLE SOMA THEORY OF senescence
    884. Inhibition of ethylene synthesis and senescence in carnation by ethanol.
    885. In vitro simulation of senescence-related membrane damage by ozone-induced lipid peroxidation
    886. Telomere-dependent senescence
    887. Stress-induced senescence in human and rodent astrocytes
    888. The evolutionary basis of leaf senescence: Method to the madness?
    889. Leaf Proteolytic Activities and senescence during Grain Development of Field-grown Corn (Zea mays L.)
    890. Hypoxia, MTOR and autophagy
      Converging on senescence or quiescence
    891. Long‐term exogenous application of melatonin delays drought‐induced leaf senescence in apple
    892. Integration of soybean pod development and monocarpic senescence
    893. Tissue damage and senescence provide critical signals for cellular reprogramming in vivo
    894. Unexpected Pieces to the senescence Puzzle
    895. Cell senescence: Role in Aging and Age-Related Diseases
    896. Disposable-soma senescence mediated by sexual selection in an ungulate
    897. Reactive oxygen species and hematopoietic stem cell senescence
    898. Biochemical changes related to aging in the senescence-accelerated mouse
    899. Programmed senescence of plant organs
    900. SOCS1 Links Cytokine Signaling to p53 and senescence
    901. The role of ascorbic acid in the control of flowering time and the onset of senescence
    902. Autophagy and senescence in Cancer Therapy
    903. Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer
    904. Aging in Legume Symbiosis. A Molecular View on Nodule senescence in Medicago truncatula
    905. A gene regulatory network controlled by the NAC transcription factor ANAC092/AtNAC2/ORE1 during salt‐promoted senescence
    906. DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence
    907. Evidence of cell loss from the rat retina during senescence
    908. Evidence for a senescence-Associated Gene Induced by Darkness
    909. Ascorbic acid, a familiar small molecule intertwined in the response of plants to ozone, pathogens, and the onset of senescence
    910. Targeting cellular senescence prevents age-related bone loss in mice
    911. Executing Cell senescence
    912. Aging and senescence in plant developent.
    913. Cortical bone senescence and mineral bone density of the humerus
    914. Control of cellular senescence by CPEB
    915. Morphological and contractile characteristics of rat cardiac myocytes from maturation to senescence
    916. p16/pRb Pathway Alterations Are Required for Bypassing senescence in Human Prostate Epithelial Cells
    917. Vemurafenib Induces senescence Features in Melanoma Cells
    918. Role of growth regulators in the senescence of Arabidopsis thaliana leaves
    919. Pigment dynamics and autumn leaf senescence in a New England deciduous forest, eastern USA
    920. Suppression of tumor growth by senescence in virally transformed human fibroblasts
    921. Factors that accelerate or retard red blood cell senescence.
    922. IndependentInductionofsenescencebyp16INK4
    923. Multiple pathways to cellular senescence: Role of telomerase repressors
    924. Octopus senescence: The Beginning of the End
    925. A new member of the Arabidopsis WRKY transcription factor family, AtWRKY6, is associated with both senescence‐ and defence‐related processes
    926. Demographic Perspectives on Human senescence
    927. Molecular mechanisms of replicative senescence in endothelial cells
    928. Does Maintaining Green Leaf Area in Sorghum Improve Yield under Drought? I. Leaf Growth and senescence
    929. Functional Aging and Gradual senescence in Zebrafish
    930. A reassessment of the telomere hypothesis of senescence
    931. Interrelationships of Ethylene and Abscisic Acid in the Control of Rose Petal senescence
    932. Promotive Effect of Methyl Jasmonate on Oat Leaf senescence in the Light
    933. senescence in podospora anserina: Amplification of a mitochondrial DNA sequence
    934. Evolution of senescence in iteroparous perennial plants
    935. Comparison of replicative senescence and stress‐induced premature senescence combining differential display and low‐density DNA arrays
    936. POLLINATION-INDUCED COROLLA senescence
    937. The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A–ARF locus in response to oncogene- and stress-induced senescence
    938. Legume nodule senescence: roles for redox and hormone signalling in the orchestration of the natural aging process
    939. Mitochondrial-Targeted Plastoquinone Derivatives. Effect on senescence and Acute Age-Related Pathologies
    940. Dark‐inducible genes from Arabidopsisthaliana are associated with leaf senescence and repressed by sugars
    941. Nitric oxide counteracts the senescence of rice leaves induced by abscisic acid
    942. Cellular senescence in Type 2 Diabetes: A Therapeutic Opportunity
    943. senescence of the retinal pigment epithelium
    944. senescence-related serine protease in parsley
    945. The Metabolism of Oat Leaves during senescence
    946. Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence.
    947. Markers of senescence?
    948. Repair of telomeric DNA prior to replicative senescence
    949. Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney
    950. Regulation of detached coriander leaf senescence by 1-methylcyclopropene and ethylene
    951. Stress-Activated MAP Kinase Cascades in Cellular senescence
    952. Cellular senescence in Vitro
    953. Inhibition of ethylene‐induced cellular senescence symptoms by 1‐methylcyclopropene, a new inhibitor of ethylene action
    954. The Complex Regulation of senescence
    955. Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence
    956. Delayed senescence of apple leaves by exogenous melatonin treatment: toward regulating the ascorbate–glutathione cycle
    957. High Levels of Brain Dolichols in Neuronal Ceroid‐Lipofuscinosis and senescence
    958. An anti-aging drug today: from senescence-promoting genes to anti-aging pill
    959. Homocysteine accelerates senescence and reduces proliferation of endothelial progenitor cells
    960. Posttranslational Modifications of p53 in Replicative senescence Overlapping but Distinct from Those Induced by DNA Damage
    961. Aging, life span, and senescence
    962. The Role of Arabidopsis Rubisco Activase in Jasmonate-Induced Leaf senescence
    963. Connecting autophagy to senescence in pathophysiology
    964. Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts
    965. miR-335 and miR-34a Promote Renal senescence by Suppressing Mitochondrial Antioxidative Enzymes
    966. senescence-Accelerated Mouse (SAM) with Special References to Neurodegeneration Models, SAMP8 and SAMP10 Mice
    967. Glycated Collagen I Induces Premature senescence-Like Phenotypic Changes in Endothelial Cells
    968. Image analysis of GFA-positive astrocytes from adolescence to senescence
    969. Escape from Therapy-Induced Accelerated Cellular senescence in p53-Null Lung Cancer Cells and in Human Lung Cancers
    970. Cloning of senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen
    971. Localization of senescent cell antigen on band 3
    972. A senescent cell bystander effect: senescence‐induced senescence
    973. senescent cell antigen is immunologically related to band 3
    974. Measurement of DNA content and cell volume in senescent human fibroblasts utilizing flow multiparameter single cell analysis
    975. A New LIM Protein Containing an Autoepitope Homologous to “senescent Cell Antigen”
    976. Generation of senescent cell antigen on old cells initiates IgG binding to a neoantigen.
    977. Mimetics of senescent cell derived inhibitors of DNA synthesis
    978. senescent Keratinocytes Die by Autophagic Programmed Cell Death
    979. Rapid disappearance of statin, a nonproliferating and senescent cell-specific protein, upon reentering the process
    980. Molecular Mechanisms for the senescent Cell Cycle Arrest
    981. Membrane Fragmentation and Ca++-Membrane Interaction : Potential Mechanisms of Shape Change in the senescent Red Cell
    982. Long-Term in vitro Growth of Human T Cell Clones: Can Postmitotic ‘senescent’ Cell Populations Be Defined?
    983. senescent cell derived inhibitors of DNA synthesis
    984. Antigenicity, storage, and aging: physiologic autoantibodies to cell membrane and serum proteins and the senescent cell antigen
    985. Aging of Cell Membrane Molecules Leads to Appearance of an Aging Antigen and Removal of senescent cells
    986. Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice
    987. Inhibition of intimal hyperplasia after vein grafting by in vivo transfer of human senescent cell-derived inhibitor-1 gene
    988. Identification of senescent cell surface targetable protein DPP4
    989. Synthetic senescent cell antigen
    990. senescent vs. non-senescent cells in the human annulus in vivo: Cell harvest with laser capture microdissection and gene expression studies with microarray analysis
    991. senescent cell derived inhibitors of DNA synthesis
    992. Glucose transport protein is structurally and immunologically related to band 3 and senescent cell antigen
    993. senescent Human Fibroblasts Resist Programmed Cell Death, and Failure to Suppress bcl2 Is Involved
    994. Duration of senescent cell survival in vitro as a characteristic of organism longevity, an additional to the proliferative potential of fibroblasts
    995. Antibodies to senescent cell-derived inhibiters of DNA synthesis
    996. Expression of cell cycle-dependent genes in young and senescent WI-38 fibroblasts
    997. Induction of senescent cell-derived inhibitor of DNA synthesis gene, SDI1, in hepatoblastoma (HepG2) cells arrested in the G2-phase of the cell cycle by 9-nitrocamptothecin.
    998. Relationship between cell replication and volume in senescent human diploid fibroblasts
    999. p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling
    1000. Cell-Cell Affinity of senescent Human Erythrocytes
    1001. The Ability to Generate senescent Progeny as a Mechanism Underlying Breast Cancer Cell Heterogeneity
    1002. senescent and quiescent cell inhibitors of DNA synthesis: Membrane-associated proteins
    1003. Pseudomonas aeruginosa Transmigrates at Epithelial Cell-Cell Junctions, Exploiting Sites of Cell Division and senescent Cell Extrusion
    1004. senescent cell antigen, band 3, and band 3 mutations in cellular aging.
    1005. SCAMP4 enhances the senescent cell secretome
    1006. senescent cell differentiation antigen.
    1007. Reinitiation of DNA Synthesis and Cell Division in senescent Human Fibroblasts by Microinjection of Anti-p53 Antibodies
    1008. Aging of cell membrane molecules: Band 3 and senescent cell antigen in neural tissue
    1009. Impaired Cell Shortening and Relengthening with Increased Pacing Frequency are Intrinsic to the senescent Mouse Cardiomyocyte
    1010. Dynamics of senescent Cell Formation and Retention Revealed by p14ARF Induction in the Epidermis
    1011. Entry into S phase is inhibited in two immortal cell lines fused to senescent human diploid cells
    1012. senescent cell death brings hopes to life
    1013. Common senescent cell‐specific antibody epitopes on fibronectin in species and cells of varied origin
    1014. senescent cell derived inhibitors of DNA synthesis
    1015. Restoration of the responsiveness to growth factors in senescent cells by an embryonic cell extract
    1016. MnSOD Upregulation Induces Autophagic Programmed Cell Death in senescent Keratinocytes
    1017. Spontaneous cell transformation: Karyoplasts derived from multinucleated cells produce new cell growth in senescent human epithelial cell cultures
    1018. senescent cell antigen: a terminal differentiation antigen.
    1019. Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2
    1020. Fibroblasts derived from Gpx1 knockout mice display senescent-like features and are susceptible to H2O2-mediated cell death
    1021. Molecular Mapping of the Active Site of an Aging Antigen: senescent Cell Antigen Requires Lysine(s) for Antigenicity and Is Located on an Anion-Binding Segment of Band 3 Membrane Transport Protein
    1022. Human platelet lysate stimulates high-passage and senescent human multipotent mesenchymal stromal cell growth and rejuvenation in vitro
    1023. Gerontology and drug development: The challenge of the senescent cell
    1024. Chlorophyll Degradation in senescent Tobacco Cell Culture (Nicotiana tabacum var. «Samsun»)
    1025. Down-regulation of Akt/PKB in senescent cardiac fibroblasts impairs PDGF-induced cell proliferation
    1026. Type 1 interferons contribute to the clearance of senescent cell
    1027. Robust nuclear lamina-based cell classification of aging and senescent cells
    1028. Simvastatin suppresses breast cancer cell proliferation induced by senescent cells
    1029. Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype
    1030. Appearance of the terminal senescent cell population in human diploid fibroblasts analyzed by flow cytometry
    1031. Some chemotherapeutics-treated colon cancer cells display a specific phenotype being a combination of stem-like and senescent cell features
    1032. mRNA levels of the differentiation-associated linker histone variant H1 zero in mitotically active and postmitotic senescent human diploid fibroblast cell populations
    1033. Method To Purify and Analyze Heterogeneous senescent Cell Populations Using a Microfluidic Filter with Uniform Fluidic Profile
    1034. Mapping of senescent cell antigen on brain anion exchanger protein (AE) isoforms using HPLC and fast atom bombardment ionization mass spectrometry (FAB‐MS)
    1035. Evaluation of a near‐senescent human dermal fibroblast cell line and effect of amelogenin
    1036. Level of macroautophagy drives senescent keratinocytes into cell death or neoplastic evasion
    1037. Genes and ageing: beyond good and evil in the senescent cell
    1038. Method of optimizing conditions for selectively removing a plurality of senescent cells from a tissue or a mixed cell population
    1039. Complementation between senescent human diploid cells and a thymidine kinase-deficient murine cell line
    1040. Targeting senescent cholangiocytes and activated fibroblasts with B‐cell lymphoma‐extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/−) mice
    1041. Diet-induced weight loss is sufficient to reduce senescent cell number in white adipose tissue of weight-cycled mice
    1042. Natural killer cell recognition of in vivo drug-induced senescent multiple myeloma cells
    1043. senescence-associated secretory factors induced by cisplatin in melanoma cells promote non-senescent melanoma cell growth through activation of the ERK1/2-RSK1 pathway
    1044. Density-gradient centrifugation enables the purification of cultured corneal endothelial cells for cell therapy by eliminating senescent cells
    1045. senescent cell clearance by the immune system: Emerging therapeutic opportunities
    1046. Life and Death of Neurons: The Role of senescent Cell Antigen
    1047. Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability
    1048. Retroviral vectors carrying senescent cell derived inhibitors 1 (SDI-1)or antisense SDI-1 nucleotide sequences
    1049. In Vitro Expansion of Human Nasoseptal Chondrocytes Reveals Distinct Expression Profiles of G1 Cell Cycle Inhibitors for Replicative, Quiescent, and senescent Culture Stages
    1050. Drug-Induced senescent Multiple Myeloma Cells Elicit NK Cell Proliferation by Direct or Exosome-Mediated IL15 Trans-Presentation
    1051. Radiation-Induced Reprogramming of Pre-senescent Mammary Epithelial Cells Enriches Putative CD44+/CD24−/low Stem Cell Phenotype
    1052. Epigallocatechin gallate suppresses premature senescence of preadipocytes by inhibition of PI3K/Akt/mTOR pathway and induces senescent cell death by regulation of Bax/Bcl-2 pathway
    1053. The senescent cell epigenome
    1054. CHAPTER 24 – senescent cell antigen and band 3 in aging and disease
    1055. The mTORC1-autophagy pathway is a target for senescent cell elimination
    1056. HPV-16 virions can remain infectious for 2 weeks on senescent cells but require cell cycle re-activation to allow virus entry
    1057. Embryonic senescent cells re-enter cell cycle and contribute to tissues after birth
    1058. Proteomics Analysis of Normal and senescent NG108-15 Cells: GRP78 Plays a Negative Role in Cisplatin-Induced senescence in the NG108-15 Cell Line
    1059. Cell surface oligosaccharide modulation during differentiation: VI. The effect of biomodulation on the senescent and neoplastic cell phenotype
    1060. Induction of Neointimal Formation by Local Gene Transfer of the Antisense senescent Cell-derived Inhibitor 1 (SDI) Delivered With the Needle Injection Catheter
    1061. Antibody Dependent Cell Mediated Cytotoxicity and Phagocytosis of senescent Erythrocytes by Autologous Peripheral Blood Mononuclear Cells
    1062. Phase-space description of the cell cycle: Application to noncycling, senescent, and transformed cells
    1063. Effect of Overproduction of Mitochondrial Uncoupling Protein 2 on Cos7 Cells: Induction of senescent-like Morphology and Oncotic Cell Death
    1064. senescent dermal fibroblasts enhance stem cell migration through CCL2/CCR2 axis
    1065. Red cell aging: senescent cell antigen, band 3, and band 3 mutations associated with cellular dysfunction.
    1066. Rock Inhibition Reduces senescent Cell Size
    1067. The senescent Cell, SC
    1068. senescent Cell Biomarkers
    1069. THE senescent CELL POPULATION WITHIN NEW BONE PRODUCED BY DISTRACTION OSTEOGENESIS
    1070. Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques
    1071. Single senescent cell sequencing reveals heterogeneity in senescent cells induced by telomere erosion
    1072. [Establishment of senescent cell model in primary rat aortic endothelial cells].
    1073. THE ROLE OF THE RETINOBLASTOMA PROTEIN IN senescent CELL CYCLE EXIT, SURVIVAL, AND MORPHOLOGICAL ALTERATION
    1074. Abstract 453: senescent Cell Depletion via Abt263 Augments Experimental Aortic Aneurysm Progression
    1075. Aging and cancer: Cell non-autonomous effects of senescent fibroblasts on tissue microenvironment
    1076. The senescent cell induced bystander effect
    1077. [senescent cell antigens in the clearance of senescent cells].
    1078. Material-induced senescence (MIS): Fluidity Induces senescent Type Cell Death of Lung Cancer Cells via Insulin-Like Growth Factor Binding Protein 5
    1079. Abstract 361: Effects of Chronic, Intermittent senescent Cell Clearance in Combination with Lipid Lowering on Inflammation in Perivascular Adipose Tissue
    1080. Active, Dormant, or on the Path to Elimination: What Does a senescent Cell Do?
    1081. The connection between the cardiac glycoside‐induced senescent cell morphology and Rho/Rho kinase pathway
    1082. Cloning of animals from senescent cell nuclei–what are the implications for aging research?
    1083. Cell Cycle Traverse and Growth Arrest Control in senescent Human Fibroblasts
    1084. senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition
    1085. Aging and cancer: Cell non-autonomous effects of senescent fibroblasts on tissue microenvironment
    1086. Klotho‐mediated targeting of CCL2 suppresses the induction of colorectal cancer progression by stromal cell senescent microenvironments
    1087. Hydroxyurea‐induced senescent peripheral blood mesenchymal stromal cells inhibit bystander cell proliferation of JAK2V617F‐positive human erythroleukemia cells
    1088. Aging and cancer: Cell non-autonomous effects of senescent fibroblasts on tissue microenvironment
    1089. Antibodies to senescent Antigen and C3 Are Not Required for Normal Red Blood Cell Lifespan in a Murine Model
    1090. Removing senescent cells from a mixed cell population or tissue using a phosphoinositide 3-kinase (pi3k) inhibitor
    1091. Differential Regulation of Methylation-Regulating Enzymes by senescent Stromal Cells Drives Colorectal Cancer Cell Response to DNA-Demethylating Epi-Drugs
    1092. senescent Pulmonary-Artery Smooth Muscle Cell (PA-SMC)-Derived Osteopontin Promotes PA-SMC Proliferation in Chronic Obstructive Pulmonary Disease
    1093. 303: A role for senescent cell-derived IL6 in HER2+ breast cancer progression
    1094. A New LIM Protein Containing an Autoepitope Homologous to ‘senescent Cell Antigen,’
    1095. Aging and the senescent cell
    1096. Differences between cytotoxicity of chemicals determined in vitro on young and old cells of a senescent cell line
    1097. Modulation of Phenotype and Induction of Apoptosis in Vascular Smooth Muscle Cells (VSMC) by Transfer of Human senescent Cell-Derived Inhibitor-1 Gene: 190
    1098. Adventitial gene transfer of the antisense to senescent cell-derived inhibitor 1 results in increased neointima
    1099. senescent CELL DERIVED INHIBITORS OF DNA SYNTHESIS
    1100. Cell cycle and apoptosis: death of a senescent cell
    1101. MIMETICS OF senescent CELL DERIVED INHIBITORS OF DNA SYNTHESIS
    1102. senescent cell distribution in human skeletal muscle : Role of exercise and protein availability
    1103. A new LIM protein containing an autoepitope homologous to’senescent cell antigen’ (vol 201, pg 1127, 1994)
    1104. Chemotherapeutics-treated cancer cells display stem-like and senescent cell features
    1105. Fisetin is a senotherapeutic that extends health and lifespan
    1106. The emerging field of senotherapeutic drugs
    1107. SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs.
    1108. Src Tyrosine Kinase Inhibitors: New Perspectives on Their Immune, Antiviral, and Senotherapeutic Potential
    1109. Senotherapy: growing old and staying young?
    1110. Senotherapy for attenuation of cellular senescence in aging and organ implantation
    1111. Targeting normal and cancer senescent cells as a strategy of senotherapy
    1112. Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)
    1113. SASP reflects senescence
    1114. SASP mediates chemoresistance and tumor-initiating-activity of mesothelioma cells
    1115. Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses
    1116. Detection of the senescence-associated secretory phenotype (SASP)
    1117. Melatonin regulates PARP 1 to control the senescence‐associated secretory phenotype (SASP) in human fetal lung fibroblast cells
    1118. Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2
    1119. SASP: tumor suppressor or promoter? Yes!
    1120. The experimental demonstration of a SASP-based full software radio receiver
    1121. Anti-TNF-α treatment modulates SASP and SASP-related microRNAs in endothelial cells and in circulating angiogenic cells
    1122. Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans
    1123. Evaluation of the mutagenicity of the anti-inflammatory drug salicylazosulfapyridine (SASP)
    1124. Whole Chromosome Instability induces senescence and promotes SASP
    1125. SASP gene delivery: a novel antibacterial approach
    1126. Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells
    1127. The small acid soluble proteins (SASP α and SASP β) of Bacillus weihenstephanensis and Bacillus mycoides group 2 are the most distinct among the Bacillus cereus …
    1128. ATM, MacroH2A. 1, and SASP: the checks and balances of cellular senescence
    1129. … absorption of 5-aminosalicylic acid (5-ASA) after administration of a 5-ASA enema and salazosulfapyridine (SASP) after an SASP suppository in Japanese volunteers
    1130. SASP (Small, Acid-Soluble Spore Proteins) and Spore Properties in Bacillus thuringiensis israelensis and Bacillus sphaericus
    1131. Isolation and identification of Lom-SG-SASP, a salivation stimulating peptide from the salivary glands of Locusta migratoria
    1132. Targeting the SASP to combat ageing: Mitochondria as possible intracellular allies?
    1133. “Social Life” of Senescent Cells: What Is SASP and Why Study It?
    1134. Synthesis and characterization of a 29-amino acid residue DNA-binding peptide derived from α/β-type small, acid-soluble spore proteins (SASP) of bacteria
    1135. Effects of NAT2 polymorphism on SASP pharmacokinetics in Chinese population
    1136. Sensitive detection and monitoring of senescence-associated secretory phenotype by SASP-RAP assay
    1137. Another classic of EU sports jurisprudence: Legal implications of Olympique Lyonnais SASP v Olivier Bernard and Newcastle UFC (C-325/08)
    1138. Clinical Observation on 30 Cases of Ulcerative Colitis of Damp Heat in the Large Intestine Stagnation Type Treated with Kuijieling Granules Combinated SASP [J]
    1139. SASP regulation by noncoding RNA
    1140. Scavenger effect of sulphasalazine (SASP), 5-aminosalicylic acid (5-ASA), and olsalazine (OAZ)
    1141. SASP, a Senescence-Associated Subtilisin Protease, is involved in reproductive development and determination of silique number in Arabidopsis
    1142. Symbol manipulation in FORTRAN: SASP I subroutines
    1143. Chronic resveratrol treatment inhibits MRC5 fibroblast SASP-related protumoral effects on melanoma cells
    1144. Pharmacokinetics of salazosulfapyridine (Sulfasalazine, SASP)(I): Plasma kinetics and plasma metabolites in the rat after a single intravenous or oral administration
    1145. Sirt1 and Parp1 as epigenome safeguards and microRNAs as SASP-associated signals, in cellular senescence and aging
    1146. SASP, a Production Planning and Control System for Shipbuilding on Individual Orders
    1147. TORn about SASP regulation
    1148. Case C-325/08, Olympique Lyonnais SASP v. Olivier Bernard and Newcastle United UFC, Judgment of the Court of Justice (Grand Chamber) of 16 March 2010
    1149. Beneficial effect of salazosulfapyridine (SASP) in a patient with secondary renal amyloidosis
    1150. Optical design and performance of the SASP spectrometer at TRIUMF
    1151. Detecting the senescence-associated secretory phenotype (SASP) by high content microscopy analysis
    1152. Pharmacokinetics of Salazosulfapyridine (Sulfasalazine, SASP)(V): Pharmacokinetics of SASP after a single intravenous or oral administration in the dog.
    1153. Comparison of SKP (semi-automated kinetic perimetry) and SASP (suprathreshold automated static perimetry) techniques in patients with advanced glaucoma
    1154. SIN3B, the SASP, and pancreatic cancer
    1155. Pharmacokinetics of Salazosulfapyridine (Sulfasalazine, SASP)(III) Metabolism and biliary excretion of SASP in the rat after a single intravenous or oral administration.
    1156. PAI-1 Regulation of TGF-β1-induced ATII Cell Senescence, SASP Secretion, and SASP-mediated Activation of Alveolar Macrophages
    1157. Maintenance treatment of ulcerative colitis (UC) with oral 5-aminosalicylic acid (5-ASA) in patients unable to take sulphasalazine (SASP)
    1158. Observation of curative effect of Sanguis Draxonis combined with SASP in the treatment of non-specific ulcerative colitis
    1159. Replica exchange molecular dynamics simulations of an α/β-type small acid soluble protein (SASP)
    1160. 98: Term fetal membranes and senescence associated secretory phenotype (SASP)-like gene expression: a signal for parturition?
    1161. COMPARATIVE STUDY OF THE EFFECT OF SULPHASALAZINE (SASP) AND 3 5 DIPS ON GLUTATHIONE (GSH) LEVEL IN RED CELLS OF HUMAN BLOOD IN …
    1162. Inhibition of neutral proteases from polymorphonuclear (PMN) neutrophils by salicylazosulfapyridine (SASP)
    1163. Senescence-associated secretory phenotype (SASP) involvement in the development of cancer, aging, and age related diseases
    1164. RNA-binding Protein Immunoprecipitation (RIP) to examine AUF1 binding to senescence-associated secretory phenotype (SASP) factor mRNA
    1165. Modified bacteriophage including an alpha/beta small acid-soluble spore protein (SASP) gene
    1166. Modified bacteriophage including an alpha/beta small acid-soluble spore protein (SASP) gene
    1167. Arabidopsis subtilase SASP is involved in the regulation of ABA signaling and drought tolerance by interacting with OPEN STOMATA 1
    1168. The first experimental demonstration of a SASP-based full Software Radio receiver
    1169. A low power digitally-enhanced SASP-based receiver architecture for mobile DVB-S applications in the Ku-band (10.7–12.75 GHz)
    1170. Senescence can be BETter without the SASP?
    1171. Cancer cell cannibalism and the SASP: Ripples in the murky waters of tumor dormancy
    1172. Methyl caffeate and some plant constituents inhibit age-related inflammation: effects on senescence-associated secretory phenotype (SASP) formation
    1173. Dissecting cellular senescence and SASP in Drosophila
    1174. 169: IL-19, a novel SASP factor, is upregulated during senescence and in response to DSBs
    1175. Growth arrest by sulfasalazine (SASP) of subrenal capsule prostate cancer xenografts in immuno-deficient mice is coupled to a decrease in the number of tumor …
    1176. COMPARISON OF THE EFFICACY OF 5 ASA AND SASP IN TREATMENT OF ULCERATIVE COLITIS
    1177. A La Recherche of Functions for the Spore Protein SASP-E from Bacillus subtilis
    1178. SASP: a symbolic algorithm for shortest paths
    1179. Molecules and Clusters in Motion: Looking Back and Looking Forward, SASP and Beyond
    1180. I no longer dread teaching physics, I now enjoy it!’Participant reflections from the SASP physics course
    1181. The salivary gland salivation stimulating peptide from Locusta migratoria (Lom-SG-SASP) is not a typical neuropeptide
    1182. Pharmacokinetics of Salazosulfapyridine (Sulfasalazine, SASP)(II) Tissue distribution and excretion of SASP in the rat after a single intravenous or oral administration.
    1183. Deciphering the mechanism for induction of senescence-associated secretory phenotype (SASP) and its role in ageing and cancer development
    1184. Optimisation of a screening platform for determining IL-6 inflammatory signalling in the senescence-associated secretory phenotype (SASP)
    1185. Overexpression of Klotho Inhibits HELF Fibroblasts SASP-related Protumoral Effects on Non-small Cell Lung Cancer Cells
    1186. SASP-Dependent Interactions between Senescent Cells and Platelets Modulate Migration and Invasion of Cancer Cells
    1187. SKYNET Applications Software Package (SASP) Operators’ and Users’ Handbook, Version 2.
    1188. The rehabilitation village-Paper presented at SASP Congress 1993
    1189. Designing in uncertainty: The I-SASP model for tactical and innovative risk management in the hi-performing professional practice
    1190. Characterization of structural changes in alpha/beta-type small, acid-soluble spore proteins (SASP) upon binding to DNA.
    1191. SASP: The future of School Psychology
    1192. Regulation of the senescence-associated secretory phenotype (SASP)
    1193. Micromanaging fibroblast senescence: The role of small non-coding RNAs in senescence associated secretory phenotype (SASP)
    1194. Effect of sulfasalazine (SASP) on sodium flux in rat colon
    1195. Senescence utilises inflammatory caspases to drive SASP
    1196. Outcome of Patients with Ankylosing Spondyloarthritis Continuing Treated with Thalidomide and SASP after a Short Course of Etanercept Therapy [J]
    1197. Study on Effect of Regulation to Th1/Th2 in AUC Patients with Chinese Medicine Combined with SASP Enema under Guidance of Synchronous Treatment of Lung …
    1198. Effect of combine probiotics with SASP on inflammatory bowel disease
    1199. Changes of T regulatory cells in rats with experimental colitis after drug treatment with SASP and PSL
    1200. Clinical effects of 99Tc-2MDP combined with SASP for ankylosing spondylitis
    1201. Ex-SASP-erating cancer
    1202. ETDEWEB/Search Results/Proceedings of the DASS/SASP (Dual Arm Spectrometer System/Second Arm Spectrometer) workshop
    1203. Immunological Responses and Protection in Dairy Cows Vaccinated with Staphylococcus aureus Surface Proteins (SASP) and Staphylococcus chromogenes …
    1204. Studies on the Role of SASP in Heat and Radiation Resistance of Bacterial Spores and on Regulation of a SASP Specific Protease
    1205. Scavenger effect of sulphasalazine (SASP)
    1206. SASP: targeted delivery to Gram-negative pathogens
    1207. Slow-Release 5-Aminosalicylic Acid (Pentasa) versus Sulphasalazine (SASP) in the Maintenance Treatment of Ulcerative Colitis (82)
    1208. SKYNET Applications Software Package (SASP) Programmers’ Handbook, Version 2.
    1209. Signatures analysis systems prototype (SASP)
    1210. PAI-1-Stimulated AT2 Cell SASP Promotes Profibrotic Polarization of Alveolar Macrophages
    1211. … serum antibodies to bacterial antigens may be used as markers for the likelihood of response to SASP could have implications regarding the tailoring of SASP …
    1212. Advances in pain management and research presented at the 2015 Scientific Meeting of the Scandinavian Association for the Study of Pain (SASP)
    1213. SASP-A digital signal processor system for speech processing applications
    1214. Poster-abstracts from SASP–The Scandinavian Association for the Study of Pain scientific meeting, Oslo, Norway, April 7–9, 2014
    1215. The salivary gland salivation stimulating peptide from Locusta migratoria (Lom-SG-SASP) is not a neuropeptide
    1216. Poor attendance at the SASP annual meeting
    1217. … OF SOLUBLE TAU AGGREGATES IN BRAIN MICROVASCULAR ENDOTHELIAL CELLS PROMOTES CELLULAR SENESCENCE/SASP AND BLOCKS ENOS …
    1218. Senescence-Associated Secretory Pheno-type (SASP)
    1219. Provisional programme for SASP congress
    1220. THE MANIPULATIVE THERAPISTS’GROUP OF THE SASP
    1221. Algorithms for arithmetic operation in a systolic array of single-bit processor (SASP)
    1222. SASP Erwin Schrödinger Gold Medal 2010
    1223. Lipid metabolism is involved in mitotic slippage-induced SASP upon treatment with anti-mitotic drugs
    1224. The role of SASP in tumor microenvironment.
    1225. Effection of Tripterygium Wilfordii Unions SASP Moves to Rheumatoid Arthritis [J]
    1226. Prospects for (p, pi) physics in the Delta region using the SASP spectrometer
    1227. Scientific presentations at the 2017 annual meeting of the Scandinavian Association for the Study of Pain (SASP)
    1228. Assessing Functional Roles of the Senescence-Associated Secretory Phenotype (SASP)
    1229. Report of first AGM of obstetric group of SASP
    1230. Conceptual design study Science and Application Space Platform SASP. Volume 1: Executive summary
    1231. Pharmacokinetics of Salazosulfapyridine (Sulfasalazine, SASP)(IV): Pharmacokinetics of SASP in the rat following consecutive oral doses.
    1232. SASP/” target=”_blank” rel=”noopener” data-saferedirecturl=”https://www.google.com/url?q=https://transhumanist-party.org/tag/SASP/&source=gmail&ust=1579109268616000&usg=AFQjCNHXsxzxNxwQBGqCzklmOCoFKpYYsg”>Browsed by Tag: SASP
    1233. Treating 150 Cases with Active Ankylosing Spondylitis with Chinese Peashrub Root Powder Capsule combined with SASP
    1234. TOE MANIPULATIVE THERAPISTS’GROUP OF THE SASP
    1235. … of long term radionuclide data for lead-210 and beryllium-7 collected at Murdoch University for the Surface Air Sampling Program (SASP) of the Environmental …
    1236. Human SLE bone marrow mesenchymal stem cells (BMSCs) have a senescence-associated secretory phenotype (SASP) mediated by a MAVS-IFNβ …
    1237. Secondary amine selective Petasis (SASP) bioconjugation
    1238. The senescence-associated secretory phenotype (SASP) from mesenchymal stromal cells impairs growth of immortalized prostate cells but has no effect on …
    1239. Convergent validity of the Richmond Reversal Rating in relation to visual-spatial perception as measured by the SASP
    1240. In Search of Nutritional Anti-Aging Targets: TOR Inhibitors, SASP Modulators And BCL-2 Family Suppressors
    1241. Non-overlapping roles of the RP and p19Arf pathways in protecting oncogenic induced HCC and their roles to modulate SASP
    1242. XXth Symposium on Atomic, Cluster and Surface Physics 2016 (SASP 2016)
    1243. Hep:: HepNames:: Institutions:: Conferences:: Jobs:: Experiments:: Journals:: Help Home> Conferences> DASS/SASP (Dual Arm Spectrometer System …
    1244. 14 ANALYSIS OF SASP REFERENCES: INSIGHTS FOR EFFECTIVE CONTINUING MEDICAL EDUCATION FOR UROLOGISTS
    1245. Correction to: Optimisation of a screening platform for determining IL-6 inflammatory signalling in the senescence-associated secretory phenotype (SASP)
    1246. Brief Overview of the ECJ Judgement in the Case of Olympique Lyonais SASP v. Olivier Bernard and Newcastle United Football Club
    1247. The Senescence-Associated Secretory Phenotype (SASP) and Redox-Dependent Invasion of Metastatic Cancer Cells
    1248. PO-112 The senescence associated secretory phenotype (SASP)-factor ccl2 fosters vascular dysfunction and endothelial cell loss in radiation-induced lung disease
    1249. Efficacy of artemisinin and SASP on chicken coccidiosis induced by Eimeria tenella.
    1250. AISA can control the inflammatory facet of SASP
    1251. Momentum Calibration for the SASP Spectrometer
    1252. … Article Folic Acid Supplementation Suppresses Sleep Deprivation-Induced Telomere Dysfunction and Senescence-Associated Secretory Phenotype (SASP)
    1253. Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase
    1254. SASP. Contributions to the 13. Symposium on atomic and surface physics and related topics
    1255. Folic Acid Supplementation Suppresses Sleep Deprivation-Induced Telomere Dysfunction and Senescence-Associated Secretory Phenotype (SASP)
    1256. SKYNET Applications Software Package (SASP) Operator’s and User’s Handbook.
    1257. Unmasking senescence: context-dependent effects of SASP in cancer
    1258. VOLUME II-TECHNICAL REPORT PART A SASP SPECIAL EMPHASIS TRADE STUDIES’k
    1259. Sexual Assault Services Program (SASP) and Sexual Offense Services (SOS)
    1260. Review of Best Practices for ICJI Program Areas: Sexual Assault Services Program (SASP) and Sexual Offense Services (SOS)
    1261. Chronic resveratrol treatment inhibits MRC5 fibroblast SASP-related pro-tumoral effects on melanoma cells
    1262. P10 CELL SURFACE INTERLEUKIN-1α, WHICH DRIVES THE SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP), IS TETHERED VIA IL …
    1263. The annual meeting of the Scandinavian Association for the Study of Pain (SASP) 18-20 April 2018− S1
    1264. Science and Applications Space Platform (SASP) End-to-End Data System Study
    1265. … Responses and Protection in Dairy Cows Vaccinated withStaphylococcus aureusSurface Proteins (SASP) andStaphylococcus chromogenes Surface Proteins …
    1266. … /REPERFUSION (I/R) INDUCED INFLAMMAGING BY INHIBITING SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) IN TUBULAR EPITHELIAL …
    1267. SASP-Symposium on atomic, cluster and surface physics’ 94
    1268. The Triumf Second Arm Spectrometer System (SASP)
    1269. Proceedings of the DASS/SASP (Dual Arm Spectrometer System/Second Arm Spectrometer) Workshop, Vancouver, March 17-18, 1986
    1270. The Abstracts of SASP 2001: The Seventh Annual Meeting of the Society of Australasian Social Psychologists
    1271. SASP’86: Symposium on atomic and surface physics
    1272. 1‐Amino‐2‐(Silyloxymethyl) Pyrrolidines (SASP)
    1273. Address at the opening Jubilee Congress of the SASP by the Minister of Health and Welfare
    1274. SASP. Symposium on atomic and surface physics’ 82. Contributions

    [HTML] Senolytics: A Translational Bridge Between Cellular Senescence and Organismal Aging

    H Thoppil, K Riabowol – Frontiers in Cell and Developmental Biology, 2019
    … Huang et al., 1999; Montero et al., 2011). These compounds form one of the first discovered members of the senolytic class of drugs that selectively induce apoptosis in senescent cells. Four years after their initial identification as …
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    BIOMARKERS FOR CELLULAR SENESCENCE

    M Demaria – US Patent App. 16/492,410, 2020
    … 15. The drug conjugate according to claim 12, wherein the cytotoxic agent is a senolytic agent, a radioisotope, a toxin or a toxic peptide. 16 … The cytotoxic agent can be a radioisotope, a toxin, toxic peptide or a senolytic drug …
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    [HTML] Potential Role of Cellular Senescence in Asthma

    ZN Wang, RN Su, BY Yang, KX Yang, LF Yang, Y Yan… – Frontiers in Cell and …, 2020
    … proteases expressed by senescent lung fibroblasts could result in low-level inflammation and fibrosis (Schafer et al., 2017; Álvarez et al., 2017). Clearance of these senescent fibroblasts by senolytic drugs would render the reso.
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    The Heterogeneity of Senescent Cells

    LITO Salon
    … However, there is no single senolytic that has been shown to target all of our senescent cells … One example is Cleara Biotechnologies, whose founder, Dr. Peter De Keizer, has talked about senolytic “cocktails” and the problem …
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    Perspectives of the potential implications of polyphenols in influencing the interrelationship between oxi-inflammatory stress, cellular senescence and …

    R Sharma, Y Padwad – Trends in Food Science & Technology, 2020
    JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page. Skip to main content Skip to article …
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    [PDF] Special issue on “Molecular genetics of aging and longevity”: a critical time in the field of geroscience

    BA Benayoun, RA Veitia
    … aging. From the perspective of precision medicine, it will be possible to identify individu- als at higher risk of developing single or multiple morbidi- ties for devising new preventive measures, such as specific senolytic treatments …
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    Pharmacotherapy to gene editing: potential therapeutic approaches for Hutchinson–Gilford progeria syndrome

    S Saxena, S Kumar – GeroScience
    … 2017). Senescent cells also upregulate the expression of anti-apoptotic proteins BCL-W and BCL-XL, the inhibition of which with siRNA or small molecules ABT-737 or ABT-263 (senolytic drugs) leads to apoptosis (Chang …

    [PDF] Establishment of a Temperature-Sensitive Model of Oncogene-Induced Senescence in Angiosarcoma Cells

    A Costa, MY Bonner, S Rao, L Gilbert, M Sasaki… – Cancers, 2020
    … the nonpermissive temperature. This suggests that the maintenance of the senescent phenotype results in a low level of p38 signaling and that p38 activators might be effective in mediating senolytic therapies. Consistent with …
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    Cancer as a disease of old age: changing mutational and microenvironmental landscapes

    E Laconi, F Marongiu, J DeGregori – British Journal of Cancer, 2020
    Why do we get cancer mostly when we are old? According to current paradigms, the answer is simple: mutations accumulate in our tissues throughout life, and some of these mutations contribute to cancers.

    Preadipocyte secretory factors differentially modulate murine macrophage functions during aging which are reversed by the application of phytochemical EGCG

    R Kumar, A Sharma, Y Padwad, R Sharma – Biogerontology
    … Working on green tea EGCG, we have previously reported its anti- immunosenescence, anti-inflammatory, anti-senescence, senolytic and synbiotic attributes thereby suggesting its multi-faceted potency as an …

    [PDF] Novel properties of mature adipocytes in obesity and hyperinsulinemia

    Q Li – 2020
    Page 1. From the Department of Cell and Molecular Biology Karolinska Institutet, Stockholm, Sweden Novel properties of mature adipocytes in obesity and hyperinsulinemia Qian Li 李 倩 Stockholm 2020 Page 2. Cover picture …

    [PDF] Establishment of a Temperature-Sensitive Model of Oncogene-Induced Senescence in Angiosarcoma Cells

    A Costa, MY Bonner, S Rao, L Gilbert, M Sasaki… – Cancers, 2020
    … the nonpermissive temperature. This suggests that the maintenance of the senescent phenotype results in a low level of p38 signaling and that p38 activators might be effective in mediating senolytic therapies. Consistent with …
    Twitter Facebook

    Cancer as a disease of old age: changing mutational and microenvironmental landscapes

    E Laconi, F Marongiu, J DeGregori – British Journal of Cancer, 2020
    Why do we get cancer mostly when we are old? According to current paradigms, the answer is simple: mutations accumulate in our tissues throughout life, and some of these mutations contribute to cancers. Although …
    Twitter Facebook

    Preadipocyte secretory factors differentially modulate murine macrophage functions during aging which are reversed by the application of phytochemical EGCG

    R Kumar, A Sharma, Y Padwad, R Sharma – Biogerontology
    … Working on green tea EGCG, we have previously reported its anti- immunosenescence, anti-inflammatory, anti-senescence, senolytic and synbiotic attributes thereby suggesting its multi-faceted potency as an …
    Twitter Facebook

    [PDF] Novel properties of mature adipocytes in obesity and hyperinsulinemia

    Q Li – 2020
    Page 1. From the Department of Cell and Molecular Biology Karolinska Institutet, Stockholm, Sweden Novel properties of mature adipocytes in obesity and hyperinsulinemia Qian Li 李 倩 Stockholm 2020 Page 2. Cover picture …

    Targeted reduction of senescent cell burden alleviates focal radiotherapy-related bone loss.

    A Chandra, AB Lagnado, JN Farr, DG Monroe, S Park… – Journal of bone and mineral …, 2020
    … To test if senolytic drugs, which clear senescent cells, alleviate FRT-related bone damage, we administered the senolytic agents, Dasatinib (D), Quercetin (Q), Fisetin (F), and a cocktail of D and Q (D+Q). We found moderate …
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    Treating cognitive decline and other neurodegenerative conditions by selectively removing senescent cells from neurological tissue

    RM Laberge, J Campisi, M Demaria, N David… – US Patent App. 16/584,638, 2020
    … US 20200030323 A1 US20200030323 A1 US 20200030323A1 US 201916584638 A US201916584638 A US 201916584638A US 2020030323 A1 US2020030323 A1 US 2020030323A1 Authority US United States Prior …
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    [HTML] Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis

    T Montero-Melendez, A Nagano, C Chelala, A Filer… – Nature Communications, 2020
    Rheumatoid arthritis affects individuals commonly during the most productive years of adulthood. Poor response rates and high costs associated with treatment mandate the search for new therapies. Here we show that targeting a specific …
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    [HTML] SENEBLOC, a long non-coding RNA suppresses senescence via p53-dependent and independent mechanisms

    CL Xu, B Sang, GZ Liu, JM Li, XD Zhang, LX Liu… – Nucleic Acids Research, 2020
    … Moreover, SENEBLOC was shown to be involved in both oncogenic and replicative senes- cence, and from the perspective of senolytic agents we show that the antagonistic actions of rapamycin on senescence are dependent on SENEBLOC ex- pression …
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    Repurposing cell penetrating peptides and their novel derivatives and iopromide and iodo-aryl carbonates for treatment of senescence-related diseases and disorders

    SS Çinarouglu, E Timucin, GB Akcapinar, U Sezerman… – US Patent App. 16/526,997, 2020
    … US2020031873A1 US 20200031873 A1 US20200031873 A1 US 20200031873A1 US 201916526997 A US201916526997 A US 201916526997A US 2020031873 A1 US2020031873 A1 US 2020031873A1 …
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    [HTML] Implications of Oxidative Stress and Cellular Senescence in Age-Related Thymus Involution

    A Barbouti, PVS Vasileiou, K Evangelou, KG Vlasis… – Oxidative Medicine and …, 2020

    The human thymus is a primary lymphoepithelial organ which supports the production of self-tolerant T cells with competent and regulatory functions. Paradoxically, despite the crucial role that it exerts in T cell-mediated immunity …

    [HTML] Taking in consideration the bystander effects of articular senescence

    JM Brondello, YM Pers – Annals of Translational Medicine, 2019
    … harboring shorten telomeres, by accumulating cycle-dependent kinases inhibitors driving senescence such as p16 Ink4a , p21 Cdkn1A and p57 KIP2 , and finally by producing deleterious catabolic and inflammatory mediators …
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    RNA Biology Provides New Therapeutic Targets for Human

    LW Harries – Role of RNA Modification in Disease, 2020
    … For example, strategies are emerging now which allow selective delivery of senolytic cargoes to senescent cells only using galactosaccharide nanoparticles, which harness the observation that senescent cells harbor …
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    The ageing epigenome and its rejuvenation

    W Zhang, J Qu, GH Liu, JCI Belmonte – Nature Reviews Molecular Cell Biology, 2020

    Ageing is characterized by the functional decline of tissues and organs and the increased risk of ageing-associated disorders. Several ‘rejuvenating’ interventions have been proposed to delay ageing and the onset of …

    [PDF] Beyond Tumor Suppression: Senescence in Cancer Stemness and Tumor Dormancy

    F Triana-Martínez, MI Loza, E Domínguez – Cells, 2020
    … with the promise of future directions on innovative anticancer therapies. Keywords: cellular senescence; stemness; dormancy; quiescence; senolytic 1. Introduction Natural tumor evolution is a complex process, composed of …
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    The Heterogeneity of Senescent Cells

    NK September
    … However, there is no single senolytic that has been shown to target all of our senescent cells … One example is Cleara Biotechnologies, whose founder, Dr. Peter De Keizer, has talked about senolytic “cocktails” and the problem …
    Twitter Facebook

    [PDF] Regorafenib Alteration of the BCL-xL/MCL-1 Ratio Provides a Therapeutic Opportunity for BH3-Mimetics in Hepatocellular Carcinoma Models

    B Cucarull, A Tutusaus, M Subías, M Stefanovic… – Cancers, 2020
    … A-1331852 has been proposed as an agent in cancer therapy [42,43] and, more recently, as a senolytic compound [44]. Interestingly, through a dual mechanism acting on senescent cholangiocytes and activated fibroblasts …
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    Cellular Senescence and Tumor Promotion

    M Demaria – Geriatric Oncology
    … rejuvenation of aged-tissue stem cells (Childs et al. 2017; Soto- Gamez and Demaria 2017). Currently, a limited number of senolytic agents have been identified. 2-DG, a false substrate for the glycolytic metabolism, or bafilomycin A1, a
    Twitter Facebook

    [PDF] Henry Ford Health System Scholarly Common s

    DE Citrin, PGS Prasanna, AJ Walker, ML Freeman…
    … this setting. Although preventing premature senescence has shown promise in preventing RIF, there is increasing interest in agents that can clear prematurely senescent cells from tissues using “senolytic” drugs. Indeed, clearance …
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    The role of adipose tissue senescence in obesity-and ageing-related metabolic disorders

    Z Liu, KKL Wu, X Jiang, A Xu, KKY Cheng – Clinical Science, 2020

    Skip to Main Content …

    [PDF] Stress-induced Cellular Senescence Contributes to Chronic Inflammation and Cancer Progression

    S KOBASHIGAWA, YM SAKAGUCHI, S MASUNAGA… – Thermal Medicine, 2019
    … In addition, a recent study demonstrated the efficacy of senolytic drugs in the selective elimination of senescent cells123); a combined treatment of dasatinib and quercetin (D+Q) was found to reduce the number of senescent …
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    [PDF] Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice

    MJ Yousefzadeh, J Zhao, C Bukata, EA Wade… – Aging Cell
    Abstract Senescent cells accumulate with age in vertebrates and promote aging largely through their senescence‐associated secretory phenotype (SASP). Many types of stress induce senescence, includi…
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    Cardiac Glycosides as Senolytic Compounds

    N Martin, O Soriani, D Bernard – Trends in Molecular Medicine, 2020
    The identification of senolytics, compounds that eliminate senescent cells, is presently a key priority given their therapeutic promise in cancer and aging-associated diseases. Two recent papers by Triana-Martínez et al. and Guerrero et al …
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    [HTML] Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype

    AJ Barinda, K Ikeda, DB Nugroho, DA Wardhana… – Nature Communications, 2020
    Vascular senescence is thought to play a crucial role in an ageing-associated decline of organ functions; however, whether vascular senescence is causally implicated in age-related disease remains unclear. Here we show that …
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    [HTML] Urogenital Support

    BI Blog, ADN Booster
    … Current research has shown that certain plant polyphenols (ie quercetin and fisetin) are strong senolytic agents (molecules that stop senescence), and have exciting potential for reducing and preventing senescence, which …
    Twitter Facebook

    [PDF] Transplanting cells from old but not young donors causes physical dysfunction in older recipients

    B Wang, Z Liu, VP Chen, L Wang, CL Inman, Y Zhou… – Aging Cell
    … Our study potentially begins new avenues of research to discover whether pharmacological interventions, such as senolytic drugs (Tchkonia & Kirkland, 2018) or anti‐inflammatory drugs, can prevent or reverse dysfunction caused …
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    [PDF] Preclinical Pharmacological Activities of Epigallocatechin-3-gallate in Signaling Pathways: An Update on Cancer

    M Sharifi-Rad, R Pezzani, M Redaelli, M Zorzan… – Molecules, 2020
    Page 1. Molecules 2020, 25, 467; doi:10.3390/molecules25030467 www.mdpi.com/ journal/molecules Review Preclinical Pharmacological Activities of Epigallocatechin- 3-gallate in Signaling Pathways: An Update on Cancer

    Senolytic compositions and uses thereof

    MA Gallop, J Klein, M Quarta – US Patent App. 16/508,477, 2020
    UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound data: image/svg+xml; base64, PD94bWwgdmVyc2lvbj0nMS4wJyBlbm…/+ IDwvcmVjdD4KPHBhdGggY2xhc3M9J2…+Cjx0ZXh0IHg9JzIyOS45MjQnIHk9JzE1… PHRzcGFuPkg8L3RzcGFuPjwvdGV4d …
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    Impaired Myofibroblast Dedifferentiation Contributes to Non-Resolving Fibrosis in Aging

    K Kato, NJ Logsdon, YJ Shin, S Palumbo, A Knox… – American Journal of …, 2020
    … One study demonstrated that the senolytic agent, quercetin, restored apoptosis susceptibility in IPF lung myofibroblasts, and inhibited fibrotic responses to lung injury in aged mice (62). Further, the first-in-human pilot study with a senolytic …
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    [HTML] Browsed by Tag: Mitochondrial mutations

    N Bagalà, S Hill
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    [PDF] Cellular senescence contributes to age‐dependent changes in circulating extracellular vesicle cargo and function

    FJ Alibhai, F Lim, A Yeganeh, PV DiStefano… – Aging Cell
    … Instead, we show that cellular senescence contributes to changes in particle cargo and function. Notably, senolytictreatment of old mice shifted plasma particle cargo and function toward that of a younger phenotype.

    Therapy-induced senescence—an induced synthetic lethality in liver cancer?

    K Wolter, L Zender – Nature Reviews Gastroenterology & Hepatology, 2020
    … cells. Therefore, the directed use of senolytic therapies in human cancers necessitates imaging modalities to non-invasively visualize TIS, thereby enabling image-guidedapplications of senolytic therapies. Full size image. Two …
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    Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice.

    MB Cavalcante, TD Saccon, ADC Nunes, JL Kirkland… – Aging, 2020
    … Collagen deposition in the uterus is related to uterine aging. Senolytic therapies are an option for reducing health complications related to aging. We investigated effects of agingand the senolytic drug combination of dasatinib plus quercetin (D+Q) on uterine fibrosis …
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    [HTML] CMV-independent increase in CD27− CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians

    C Martin-Ruiz, J Hoffmann, E Shmeleva, T von Zglinicki… – npj Aging and Mechanisms …, 2020
    … p < 0.001; **p < 0.01; *p < 0.05 using 1-way ANOVA. Full size image. Senolytic therapy … The gating scheme is depicted in Fig. 2a. Animals, procedures and senolytictreatment. C57BL/6 mice were analyzed at either …
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    Dasatinib, a second-generation tyrosine kinase inhibitor, induces melanogenesis via ERK-CREB-MITF-tyrosinase signaling in normal human melanocytes

    B Kang, Y Kim, TJ Park, HY Kang – Biochemical and Biophysical Research …, 2020
    … allergic asthma. Br. J. Pharmacol., 173 (2016), pp. 1236-1247. Google Scholar. [8] JL Kirkland, T. Tchkonia, Y. Zhu, LJ Niedernhofer, PD RobbinsThe clinical potential of senolytic drugs. J. Am. Geriatr. Soc., 65 (2017), pp. 2297 …
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    [PDF] The role of the microbiota in sedentary life style disorders and ageing: Lessons from the animal kingdom

    PW O’Toole, PG Shiels – Journal of Internal Medicine, 2020
    … Nrf2 regulates over 390 stress defence genes linked to longevity and health span. Moreover, alkyl catechols comprise a group of chemicals that include the senolytic agents fisetin and quercetin, which have proven efficacy in …
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    [HTML] Browsed by Tag: cancer

    G Stolyarov II, A Grases
    … When I am 85, the senolytic DNA machinery will be far from the only addition to my cells … Inflammatory conditions of aging will be a shadow of what they once were, because of senolytic therapies presently under development …
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    Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation–induced impairment of neurovascular coupling responses protecting …

    A Yabluchanskiy, S Tarantini, P Balasubramanian… – GeroScience
    … Data are expressed as mean ± SEM. Results. WBI induces astrocyte senescence: protective effects of senolytictreatments … 3d, e). WBI impairs eicosanoid gliotransmitter-mediated NVC responses: protective effects of senolytictreatments …
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    [HTML] Astrocyte Support for Oligodendrocyte Differentiation can be Conveyed via Extracellular Vesicles but Diminishes with Age

    CM Willis, AM Nicaise, ER Bongarzone, M Givogri… – Scientific Reports, 2020
    The aging brain is associated with significant changes in physiology that alter the tissue microenvironment of the central nervous system (CNS). In the aged CNS, increased demyelination has been associated with astrocyte hypertrophy …
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    [HTML] TGF-β1/IL-11/MEK/ERK signaling mediates senescence-associated pulmonary fibrosis in a stress-induced premature senescence model of Bmi-1 deficiency

    H Chen, H Chen, J Liang, X Gu, J Zhou, C Xie, X Lv… – Experimental & Molecular …, 2020
    To study whether TGF-β1/IL-11/MEK/ERK (TIME) signaling mediates senescence-associated pulmonary fibrosis (SAPF) in Bmi-1-deficient (Bmi-1−/−) mice and determines the major downstream mediator of Bmi-1 …

    [HTML] Underlying Histopathology Determines Response to Oxidative Stress in Cultured Human Primary Proximal Tubular Epithelial Cells

    MA Khan, X Wang, KTK Giuliani, P Nag, A Grivei… – International Journal of …, 2020
    Proximal tubular epithelial cells (PTEC) are key players in the progression of kidney diseases. PTEC studies to date have primarily used mouse models and transformed human PTEC lines. However, the translatability of these …
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    [HTML] Metabolic Syndrome Support

    BI Blog, HIA You
    … Current research has shown that certain plant polyphenols (ie quercetin and fisetin) are strong senolytic agents (molecules that stop senescence), and have exciting potential for reducing and preventing senescence, which …
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    PDF] Senescent Colon and Breast Cancer Cells Induced by Doxorubicin Exhibit Enhanced Sensitivity to Curcumin, Caffeine, and Thymoquinone

    AH El-Far, NHE Darwish, SA Mousa – Integrative Cancer Therapies, 2020
    Cellular senescence is a process of physiological growth arrest that can be induced by intrinsic or extrinsic stress signals. Some cancer therapies are associated with senescence of cancer cells wi…
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    Targeting defective pulmonary innate immunity–A new therapeutic option?

    KBR Belchamber, LE Donnelly – Pharmacology & Therapeutics, 2020
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    Targeting the progression of chronic kidney disease

    M Ruiz-Ortega, S Rayego-Mateos, S Lamas, A Ortiz… – Nature Reviews Nephrology, 2020
    Chronic kidney disease (CKD) is a devastating condition that is reaching epidemic levels owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well as ageing of the population. Regardless …
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    Cellular senescence: from anti-cancer weapon to anti-aging target

    L Yuan, PB Alexander, XF Wang – Science China Life Sciences, 2020
    Cellular senescence (CS) is a state of stable cell cycle arrest characterized by the production and secretion of inflammatory molecules. Early studies desc.
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    [PDF] Targeting Age-Related Pathways in Heart Failure

    H Li, MH Hastings, J Rhee, LE Trager, JD Roh… – Circulation Research, 2020
    During aging, deterioration in cardiac structure and function leads to increased susceptibility to heart failure. The need for interventions to combat this age-related cardiac decline is becoming i…
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    [HTML] Autophagy Reprograms Alveolar Progenitor Cell Metabolism in Response to Lung Injury

    X Li, J Wu, X Sun, Q Wu, Y Li, K Li, Q Zhang, Y Li… – Stem Cell Reports, 2020
    JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page. Skip to main content Skip to article …
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    [HTML] A Newly Synthesized Rhamnoside Derivative Alleviates Alzheimer’s Amyloid-β-Induced Oxidative Stress, Mitochondrial Dysfunction, and Cell Senescence through …

    Y Li, J Lu, X Cao, H Zhao, L Gao, P Xia, G Pei – Oxidative Medicine and Cellular …, 2020
    Oxidative stress-induced mitochondrial dysfunction and cell senescence are considered critical contributors to Alzheimer’s disease (AD), and oxidant/antioxidant imbalance has been a therapeutic target in AD. SIRT3 …
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