• SHOP
    • COMBOS
    • TESTIMONIALS
    • CART
    • INGREDIENTS
      • 2-Deoxy-D-Glucose (2DG)
      • Acacia Cyanophylla Flower
      • Acori Graminei Rhizoma
      • Aegle Marmelos Correa
      • Agaricus Blazei
      • Aged Garlic Extract
      • Aframomum Melegueta
      • Aloe Arborescens
      • Albizia
      • Alpinia Officinarum
      • Alternanthera Sessilis
      • American Ginseng
      • Amygdalin
      • Anacyclus Pyrethrum
      • Angelica Archangelica
      • Angelica Sinensis
      • Antrodia
      • Artichoke Leaf
      • Artocarpin
      • Ajuga Turkestanica
      • Ashwagandha
      • Aspalathin
      • Astragalus Complanatus
      • Avena Sativa
      • Bacopa Monnieri
      • Bavachin
      • Bee Pollen
      • Betulinic Acid
      • Boswellic Acid
      • Brevilin A
      • Campesterol
      • Casticin
      • Chrysin
      • Cinnamomum Zeylanicum
      • Citrullus Colocynthis
      • Citrus Reticulata Peel
      • Codonopsis
      • Costunolide
      • Cucurbitacin D
      • Daidzein
      • Decursin
      • Delphinidin
      • Digitalis Purprea (Digoxin)
      • Diosmin
      • Embelin
      • Gallic Acid
      • Glycitein
      • Glycyrrhizin
      • Hyperforin
      • Icariin
      • Isorhamnetin
      • Isoorientin
      • Isovitexin
      • Jaceosidin
      • Kaempferol
      • Kurarinone
      • Lemon balm
      • Licoricidin
      • Lipoic acid
      • Lupeol
      • Magnolol
      • Mulberry Leaf
      • Naringenin
      • Nobiletin
      • Oleacein
      • Oleanolic acid
      • Oridonin
      • Parthenolide
      • Phloroglucinol
      • Piceatannol
      • Pristimerin
      • Proanthocyanidins
      • Procyanidin B3
      • Pseudolaric acid b
      • Pterostilbene
      • Rutin
      • Solidago Virgaurea
      • Tangeretin
      • Taraxasterol
      • Trichostatin A
      • Wedelolactone
      • Wogonin
      • Yerba Mate
    • ABOUT
    • SCIENTIFIC STUDIES
      • ALLERGIES & CYTOKINES
      • ANTI-ACNE EFFECT OF FLAVONOIDS AND POLYPHENOLS
      • ADVANCED GLYCATION END PRODUCTS (AGES)
      • AMPK
      • ANTI-AGING EFFECTS OF FLAVONOIDS & POLYPHENOLS
      • ANTI-APOPTOTIC PATHWAYS
      • ANTI-CANCER EFFECTS OF FLAVONOIDS & POLYPHENOLS
      • ANTI-INFLAMMATORY EFFECTS OF FLAVONOIDS & POLYPHENOLS
      • ANTI-VIRAL EFFECTS OF FLAVONOIDS & POLYPHENOLS
      • APOPTOSIS
      • AUTOPHAGY
      • BCL-2
      • BCL-W
      • BCL-XL
      • BECLIN-1 & AUTOPHAGY
      • BH3 MIMETICS
      • BIM aka BCL2L11
      • BMI-1
      • CARDIAC GLYCOSIDES
      • CENTENARIANS
      • CYP2E1
      • CYTOKINES IN PAIN, INFLAMMATION & AGING
      • DAF-16
      • EPIGENETIC MODIFIERS
      • FGF21
      • KLOTHO
      • FASTING, CALORIE RESTRICTION & EXTENDING LIFESPAN
      • FOXO3
      • FOXO4
      • HMGB1
      • HSP90 INHIBITORS
      • HYPERINSULINEMIA
      • IKK
      • IL-6/STAT3
      • INFECTOBESITY
      • INFLAMMATION & ANXIETY
      • INFLAMMATION & CANCER
      • INFLAMMATION & DEPRESSION
      • INFLAMMATION & OBESITY
      • INFLAMMAGING
      • INSULIN & AGING
      • JAK INHIBITION ALLEVIATES SASP
      • JNK ACTIVATION PREVENTS PREMATURE SENESCENCE
      • KETONE BODIES
      • KETOGENIC DIET
      • LIFESPAN EXTENSION
      • MATRIX METALLOPROTEINASES (MMPs)
      • MCL-1
      • MDM2 INHIBITION AS SASP INHIBITOR
      • MSG (MONOSOSODIUM GLUTAMATE)
      • mTOR: THE RAPID AGING PATHWAY
      • NEUROINFLAMMATION
      • NMDA & ANXIETY & DEPRESSION
      • NOOTROPICS
      • NRF2: MASTER REGULATOR OF THE AGING PROCESS
      • NF-KB
      • ONCOGENE ACTIVATION INDUCED SENESCENCE
      • OXIDATIVE STRESS & AGING
      • P16INK4A
      • P38MAPK
      • P53: TUMOR SUPRESSOR
      • PPARY2
      • PREMATURE SENESCENCE
      • SASP & ADIPOSE TISSUE
      • SENESCENT CELLS, SASP & SENOLYTICS
      • SENESCENCE-BETA-GALACTOSIDASE (SA-β-gal or SABG)
      • SKIN PHOTOAGING (Preventing & Repairing)
      • SIRT1 & LONGEVITY
      • SUGAR & AGING
      • STAT3
      • TELOMERE SHORTENING & PREMATURE AGING
    • HOME
    • FAQ
    • CONTACT
    • INTERSTELLAR 88/8: EXTREME WEIGHTLOSS PROTOCOL
    • The Ultimate Dry Fasting Resource
    Klotho
    July 30, 2019
    HSP90
    January 6, 2020
    1. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
    2. Human SIR2 deacetylates p53 and antagonizes PML/p53‐induced cellular senescence
    3. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
    4. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    5. PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
    6. Regulation of cellular senescence by p53
    7. Reversal of human cellular senescence: roles of the p53 and p16 pathways
    8. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
    9. A role for both RB and p53 in the regulation of human cellular senescence
    10. Senescence and aging: the critical roles of p53
    11. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy
    12. Paradoxical suppression of cellular senescence by p53
    13. Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence
    14. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
    15. Oncogenic ras and p53 cooperate to induce cellular senescence
    16. Escape from senescence in human diploid fibroblasts induced directly by mutant p53.
    17. Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53
    18. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21CIP1, but not p16INK4a
    19. Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence
    20. JunD protects cells from p53-dependent senescence and apoptosis
    21. Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer
    22. p53, ROS and senescence in the control of aging
    23. Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction
    24. Pathways connecting telomeres and p53 in senescence, apoptosis, and cancer
    25. Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53
    26. p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC
    27. SIRT1 and p53, effect on cancer, senescence and beyond
    28. Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence
    29. Weak p53 permits senescence during cell cycle arrest
    30. The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway
    31. Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence
    32. Significant role for p16INK4a in p53-independent telomere-directed senescence
    33. Tumour suppression by p53: the importance of apoptosis and cellular senescence
    34. Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence.
    35. Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53‐dependent cellular senescence
    36. p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence
    37. DNA damage signaling and p53-dependent senescence after prolonged β-interferon stimulation
    38. Suppression of p53-dependent senescence by the JNK signal transduction pathway
    39. A two-stage, p16INK4A-and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status
    40. Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells
    41. Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform
    42. p53-independent regulation of p21Waf1/Cip1 expression and senescence by Chk2
    43. ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence
    44. Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs
    45. Hsp27 modulates p53 signaling and suppresses cellular senescence
    46. Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage
    47. Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers
    48. A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19ARF–p53 signaling
    49. p53 Mediates the accelerated onset of senescence of endothelial progenitor cells in diabetes
    50. p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer
    51. PML interaction with p53 and its role in apoptosis and replicative senescence
    52. SOCS1 links cytokine signaling to p53 and senescence
    53. The p400 E1A-associated protein is a novel component of the p53→ p21 senescence pathway
    54. Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice
    55. p53: guardian of cellular senescence
    56. From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: the telomere loss/DNA damage model of cell aging
    57. Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence
    58. Senescence regulation by the p53 protein family
    59. The M‐type receptor PLA2R regulates senescence through the p53 pathway
    60. Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence
    61. Manganese superoxide dismutase induces p53-dependent senescence in colorectal cancer cells
    62. Apoptosis or senescence-like growth arrest: influence of cell-cycle position, p53, p21 and bax in H2O2 response of normal human fibroblasts
    63. p21Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53
    64. … damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence
    65. p53-Dependent accelerated senescence induced by ionizing radiation in breast tumour cells
    66. ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation
    67. Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence
    68. http://genesdev.cshlp.org/content/16/22/2923.short
    69. CPEB regulation of human cellular senescence, energy metabolism, and p53 mRNA translation
    70. Disturbed flow promotes endothelial senescence via a p53-dependent pathway
    71. p53-dependent translational control of senescence and transformation via 4E-BPs
    72. Deregulation of oncogene‐induced senescence and p53 translational control in X‐linked dyskeratosis congenita
    73. Cellular senescence: ex vivo p53-dependent asymmetric cell kinetics
    74. Induced p53 expression in lung cancer cell line promotes cell senescence and differentially modifies the cytotoxicity of anti-cancer drugs
    75. p53 is preferentially recruited to the promoters of growth arrest genes p21 and GADD45 during replicative senescence of normal human fibroblasts
    76. Mutant p53 rescues human diploid cells from senescence without inhibiting the induction of SDI1/WAF1
    77. H2O2 accelerates cellular senescence by accumulation of acetylated p53 via decrease in the function of SIRT1 by NAD+ depletion
    78. Expression of SUMO-2/3 induced senescence through p53-and pRB-mediated pathways
    79. Cooperative interactions between RB and p53 regulate cell proliferation, cell senescence, and apoptosis in human vascular smooth muscle cells from atherosclerotic …
    80. DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence
    81. Interferon-γ induces cellular senescence through p53-dependent DNA damage signaling in human endothelial cells
    82. 5‐Lipoxygenase regulates senescence‐like growth arrest by promoting ROS‐dependent p53 activation
    83. Induction of p53-dependent senescence by the MDM2 antagonist nutlin-3a in mouse cells of fibroblast origin
    84. Definition of pRB-and p53-dependent and-independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci
    85. Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence
    86. Transient activation of p53 in G2 phase is sufficient to induce senescence
    87. A dominant role for p53-dependent cellular senescence in radiosensitization of human prostate cancer cells
    88. Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence
    89. Sodium Butyrate Induces NIH3T3 cells to senescence-like state and enhances promoter activity of p21WAF/CIP1in p53-Independent manner
    90. Chronic treatment with resveratrol induces redox stress-and ataxia telangiectasia-mutated (ATM)-dependent senescence in p53-positive cancer cells
    91. Human fibroblasts require the Rb family of tumor suppressors, but not p53, for PML-induced senescence
    92. Klotho RNAi induces premature senescence of human cells via a p53/p21 dependent pathway
    93. Caveolin-1 regulates the antagonistic pleiotropic properties of cellular senescence through a novel Mdm2/p53-mediated pathway
    94. AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy
    95. p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6
    96. Activation of p53 by nutlin-3a induces apoptosis and cellular senescence in human glioblastoma multiforme
    97. p53 and its homologues, p63 and p73, induce a replicative senescence through inactivation of NF-Y transcription factor
    98. Dynamic regulation of p53 subnuclear localization and senescence by MORC3
    99. Splicing-factor oncoprotein SRSF1 stabilizes p53 via RPL5 and induces cellular senescence
    100. The relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescence
    101. MOZ increases p53 acetylation and premature senescence through its complex formation with PML
    102. p53-dependent senescence delays Eμ-myc-induced B-cell lymphomagenesis
    103. Shifting senescence into quiescence by turning up p53
    104. Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate
    105. Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence
    106. The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence
    107. Repression of the human papillomavirus E6 gene initiates p53-dependent, telomerase-independent senescence and apoptosis in HeLa cervical carcinoma cells
    108. … papillomavirus oncoprotein E7 targets the promyelocytic leukemia protein and circumvents cellular senescence via the Rb and p53 tumor suppressor pathways
    109. p53 mediates senescence-like arrest induced by chronic replicational stress
    110. Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging
    111. Characterization of the p53 response to oncogene-induced senescence
    112. Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence
    113. Bach1 inhibits oxidative stress–induced cellular senescence by impeding p53 function on chromatin
    114. Ionizing radiation‐induced long‐term expression of senescence markers in mice is independent of p53 and immune status
    115. Control of p53 and NF-κB signaling by WIP1 and MIF: role in cellular senescence and organismal aging
    116. WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway
    117. UVB-induced senescence in human keratinocytes requires a functional insulin-like growth factor-1 receptor and p53
    118. SOCS1, a novel interaction partner of p53 controlling oncogene-induced senescence
    119. Senescence-associated alterations of cytoskeleton: extraordinary production of vimentin that anchors cytoplasmic p53 in senescent human fibroblasts
    120. Pharmacologic p53 activation blocks cell cycle progression but fails to induce senescence in epithelial cancer cells
    121. Mdm2–p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin
    122. CENP-A reduction induces a p53-dependent cellular senescence response to protect cells from executing defective mitoses
    123. Insulin‐like growth factor‐1 regulates the SIRT 1‐p53 pathway in cellular senescence
    124. Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression
    125. YPEL3, a p53-regulated gene that induces cellular senescence
    126. TGF-β signaling engages an ATM-CHK2-p53–independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial cells
    127. p53 isoforms regulate aging-and tumor-associated replicative senescence in T lymphocytes
    128. The ARF-p53 senescence pathway in mouse and human cells
    129. Nek6 overexpression antagonizes p53-induced senescence in human cancer cells
    130. An accelerated senescence response to radiation in wild-type p53 glioblastoma multiforme cells
    131. Molecular chaperones regulate p53 and suppress senescence programs
    132. Contribution of p16INK4a and p21CIP1 pathways to induction of premature senescence of human endothelial cells: permissive role of p53
    133. Indoxyl sulfate promotes vascular smooth muscle cell senescence with upregulation of p53, p21, and prelamin A through oxidative stress
    134. β-catenin expression results in p53-independent DNA damage and oncogene-induced senescence in prelymphomagenic thymocytes in vivo
    135. Hyperoxia-induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS
    136. p53_inducing_drug_dosage_may_determine_quiescence_or_senescence/links/54ccad9b0cf298d6565aaada.pdf”>The p53 inducing drug dosage may determine quiescence or senescence
    137. Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p53
    138. Negative regulation of transcription factor FoxM1 by p53 enhances oxaliplatin-induced senescence in hepatocellular carcinoma
    139. Knockin mice expressing a chimeric p53 protein reveal mechanistic differences in how p53 triggers apoptosis and senescence
    140. Indoxyl sulfate induces endothelial cell senescence by increasing reactive oxygen species production and p53 activity
    141. Repression of the SUMO‐specific protease Senp1 induces p53‐dependent premature senescence in normal human fibroblasts
    142. Cooperation between p53 and p130 (Rb2) in induction of cellular senescence
    143. Resistance to UV‐induced apoptosis in human keratinocytes during accelerated senescence is associated with functional inactivation of p53
    144. Vitamin C inhibits p53-induced replicative senescence through suppression of ROS production and p38 MAPK activity
    145. Inactivation of p53 function in cultured human mammary epithelial cells turns the telomere-length dependent senescence barrier from agonescence into crisis
    146. The ATM/p53/p21 pathway influences cell fate decision between apoptosis and senescence in reoxygenated hematopoietic progenitor cells
    147. hAda3 regulates p14ARF-induced p53 acetylation and senescence
    148. Perturbation of ribosome biogenesis drives cells into senescence through 5S RNP-mediated p53 activation
    149. p53 and p16INK4A independent induction of senescence by chromatin-dependent alteration of S-phase progression
    150. Aurora A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice
    151. Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells
    152. Activation of PPARγ/p53 signaling is required for curcumin to induce hepatic stellate cell senescence
    153. MageA2 restrains cellular senescence by targeting the function of PMLIV/p53 axis at the PML-NBs
    154. Expression profiles of p53 and p66shc during oxidative stress-induced senescence in fetal bovine fibroblasts
    155. Oxidative stress-induced inhibition of Sirt1 by caveolin-1 promotes p53-dependent premature senescence and stimulates the secretion of interleukin 6 (IL-6)
    156. Telomeres, p53 and cellular senescence
    157. Ha-RasG12V induces senescence in primary and immortalized human esophageal keratinocytes with p53 dysfunction
    158. Low concentration of metformin induces a p53-dependent senescence in hepatoma cells via activation of the AMPK pathway
    159. Bcl-2 can promote p53-dependent senescence versus apoptosis without affecting the G1/S transition
    160. Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification
    161. Redox control and interplay between p53 isoforms: roles in the regulation of basal p53 levels, cell fate, and senescence
    162. Bcl-xL and E1B-19K proteins inhibit p53-induced irreversible growth arrest and senescence by preventing reactive oxygen species-dependent p38 activation
    163. Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence
    164. Expression of an IFN-inducible cellular senescence gene, IFI16, is up-regulated by p53
    165. Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?
    166. Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging
    167. Sunitinib induces cellular senescence via p53/D ec1 activation in renal cell carcinoma cells
    168. Irradiation of adult human dental pulp stem cells provokes activation of p53, cell cycle arrest, and senescence but not apoptosis
    169. SCFFbxo22-KDM4A targets methylated p53 for degradation and regulates senescence
    170. Influence of p53 and caspase 3 activity on cell death and senescence in response to methotrexate in the breast tumor cell
    171. Rb2/p130 is the dominating pocket protein in the p53–p21 DNA damage response pathway leading to senescence
    172. CLCA2 as a p53-inducible senescence mediator
    173. Culturing on Wharton’s jelly extract delays mesenchymal stem cell senescence through p53 and p16INK4a/pRb pathways
    174. Reduced mitochondrial membrane potential and altered responsiveness of a mitochondrial membrane megachannel in p53-induced senescence
    175. 20 (S)-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway
    176. Possible involvement of p21 but not of p16 or p53 in keratinocyte senescence
    177. Expression of hepaCAM is downregulated in cancers and induces senescence-like growth arrest via a p53/p21-dependent pathway in human breast cancer cells
    178. p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells
    179. Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence
    180. Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality
    181. Interstitial chromatin alteration causes persistent p53 activation involved in the radiation-induced senescence-like growth arrest
    182. Role of in Replicative Senescence and DNA Damage-Induced Premature Senescence in p53-Deficient Human Cells
    183. NORE1A is a Ras senescence effector that controls the apoptotic/senescent balance of p53 via HIPK2
    184. Autophagic degradation of the inhibitory p53 isoform Δ133p53α as a regulatory mechanism for p53-mediated senescence
    185. Induction of Cellular Senescence by Secretory Phospholipase A2 in Human Dermal Fibroblasts through an ROS-Mediated p53 Pathway
    186. p63 and p73 coordinate p53 function to determine the balance between survival, cell death, and senescence in adult neural precursor cells
    187. IGFBP-rP1 induces p21 expression through a p53-independent pathway, leading to cellular senescence of MCF-7 breast cancer cells
    188. Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence
    189. Nutlin-3, the small-molecule inhibitor of MDM2, promotes senescence and radiosensitises laryngeal carcinoma cells harbouring wild-type p53
    190. Activation of p53 with Nutlin-3a radiosensitizes lung cancer cells via enhancing radiation-induced premature senescence
    191. … peroxide induced premature senescence: senescence-associated β-galactosidase and DNA synthesis index in human diploid fibroblasts with down-regulated p53 or …
    192. Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: in vivo and in vitro evidence
    193. MDM2 inhibitor nutlin-3a induces apoptosis and senescence in cutaneous T-cell lymphoma: role of p53
    194. Replicative senescence in sheep fibroblasts is a p53 dependent process
    195. IGF-I enhances cellular senescence via the reactive oxygen species–p53 pathway
    196. The p53-p21Cip1/WAF1 pathway is necessary for cellular senescence induced by the inhibition of protein kinase CKII in human colon cancer cells
    197. Metformin and resveratrol inhibited high glucose-induced metabolic memory of endothelial senescence through SIRT1/p300/p53/p21 pathway
    198. p53-dependent induction of prostate cancer cell senescence by the PIM1 protein kinase
    199. Wnt/β-catenin signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients through the p53/p21 pathway
    200. Reactive oxygen species and p21Waf1/Cip1 are both essential for p53-mediated senescence of head and neck cancer cells
    201. Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging
    202. p53-Rb signaling pathway is involved in tubular cell senescence in renal ischemia/reperfusion injury
    203. Down‐regulation of Aurora B kinase induces cellular senescence in human fibroblasts and endothelial cells through a p53‐dependent pathway
    204. Interferon-β induces cellular senescence in cutaneous human papilloma virus-transformed human keratinocytes by affecting p53 transactivating activity
    205. Physiological ageing: role of p53 and PARP-1 tumor suppressors in the regulation of terminal senescence
    206. POZ/BTB and AT-hook-containing zinc finger protein 1 (PATZ1) inhibits endothelial cell senescence through a p53 dependent pathway
    207. Dehydroepiandrosterone inhibits the progression phase of mammary carcinogenesis by inducing cellular senescence via a p16-dependent but p53 …
    208. PML IV/ARF interaction enhances p53 SUMO-1 conjugation, activation, and senescence
    209. p53-induced autophagy and senescence
    210. Cell contact accelerates replicative senescence of human mesenchymal stem cells independent of telomere shortening and p53 activation: roles of Ras and oxidative …
    211. ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets
    212. Methylseleninic acid superactivates p53-senescence cancer progression barrier in prostate lesions of pten-knockout mouse
    213. The BRG1 ATPase of chromatin remodeling complexes is involved in modulation of mesenchymal stem cell senescence through RB–p53 pathways
    214. p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage
    215. Dexamethasone reduces sensitivity to cisplatin by blunting p53-dependent cellular senescence in non-small cell lung cancer
    216. Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal …
    217. BCL6-mediated attenuation of DNA damage sensing triggers growth arrest and senescence through a p53-dependent pathway in a cell context-dependent manner
    218. 2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-d-glucoside ameliorates vascular senescence and improves blood flow involving a mechanism of p53 deacetylation
    219. Busulfan selectively induces cellular senescence but not apoptosis in WI38 fibroblasts via a p53-independent but extracellular signal-regulated kinase-p38 mitogen …
    220. Loss of the osteogenic differentiation potential during senescence is limited to bone progenitor cells and is dependent on p53
    221. Novel ARF/p53-independent senescence pathways in cancer repression
    222. FL118 induces p53-dependent senescence in colorectal cancer cells by promoting degradation of MdmX
    223. p53 deacetylation by SIRT1 decreases during protein kinase CKII downregulation-mediated cellular senescence
    224. Induction of senescence-like phenotype and loss of paclitaxel sensitivity after wild-type p53 gene transfection of p53-null human non-small cell lung cancer H358 cells …
    225. Nucleophosmin 1, upregulated in adenomas and cancers of the colon, inhibits p53‐mediated cellular senescence
    226. Phosphatidylcholine‐specific phospholipase C, p53 and ROS in the association of apoptosis and senescence in vascular endothelial cells
    227. Suppression of the p53-dependent replicative senescence response by lysophosphatidic acid signaling
    228. Chemokine receptor CXCR 2 is transactivated by p53 and induces p38‐mediated cellular senescence in response to DNA damage
    229. Another”” Janus paradox”” of p53: induction of cell senescence versus quiescence
    230. A new p53 target gene, RKIP, is essential for DNA damage-induced cellular senescence and suppression of ERK activation
    231. … a senescence-like change via the down-regulation of SIRT1 and up-regulation of p53 protein in human esophageal squamous cancer cells with a wild-type p53 gene …
    232. A single-codon mutation converts HPV16 E6 oncoprotein into a potential tumor suppressor, which induces p53-dependent senescence of HPV-positive HeLa …
    233. Multiple facets of p53 in senescence induction and maintenance
    234. Regulation of p53 during senescence in normal human keratinocytes
    235. mTOR favors senescence over quiescence in p53-arrested cells
    236. Wild-type and Hupki (Human p53 Knock-in) Murine Embryonic Fibroblasts p53/ARF PATHWAY DISRUPTION IN SPONTANEOUS ESCAPE FROM SENESCENCE
    237. Cellular senescence induced by p53‐ras cooperation is independent of p21waf1 in murine embryo fibroblasts
    238. Role for p53 in selenium-induced senescence
    239. IGF-I induces senescence of hepatic stellate cells and limits fibrosis in a p53-dependent manner
    240. The p53/p21WAF/CIP Pathway Mediates Oxidative Stress and Senescence in Dyskeratosis Congenita Cells with Telomerase Insufficiency
    241. Arginase‐II Induces Vascular Smooth Muscle Cell Senescence and Apoptosis Through p66Shc and p53 Independently of Its l‐Arginine Ureahydrolase Activity …
    242. Be quiet and you’ll keep young: does mTOR underlie p53 action in protecting against senescence by favoring quiescence?
    243. TRIB3 promotes APL progression through stabilization of the oncoprotein PML-RARα and inhibition of p53-mediated senescence
    244. ATP‐citrate lyase regulates cellular senescence via an AMPK‐and p53‐dependent pathway
    245. Loss of BRG1 induces CRC cell senescence by regulating p53/p21 pathway
    246. … p53 codon 72 Pro/Pro genotype identifies poor-prognosis neuroblastoma patients: correlation with reduced apoptosis and enhanced senescence by the p53 …
    247. Inhibition enhancer of zeste homologue 2 promotes senescence and apoptosis induced by doxorubicin in p53 mutant gastric cancer cells
    248. CHIP-dependent p53 regulation occurs specifically during cellular senescence
    249. ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence
    250. Contribution of estrogen receptor α to oncogenic K-Ras-mediated NIH3T3 cell transformation and its implication for escape from senescence by modulating the p53 …
    251. Molecular insights into SIRT1 protection against UVB-induced skin fibroblast senescence by suppression of oxidative stress and p53 acetylation
    252. MAD2 depletion triggers premature cellular senescence in human primary fibroblasts by activating a p53 pathway preventing aneuploid cells propagation
    253. 58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway
    254. Retinoblastoma‐independent regulation of cell proliferation and senescence by the p53–p21 axis in lamin A/C‐depleted cells
    255. The regulation of cellular functions by the p53 protein: cellular senescence
    256. p53/p21 Pathway involved in mediating cellular senescence of bone marrow-derived mesenchymal stem cells from systemic lupus erythematosus patients
    257. Elevated p53 expression in benign meningiomas protects against recurrence and may be indicative of senescence
    258. p53: The pivot between cell cycle arrest and senescence
    259. RRM2B suppresses activation of the oxidative stress pathway and is up-regulated by p53 during senescence
    260. Partial proteasome inhibition in human fibroblasts triggers accelerated M1 senescence or M2 crisis depending on p53 and Rb status
    261. … suppression of HMGB1 induces cell cycle arrest and senescence in association with p21 (Waf1/Cip1) up-regulation via a p53-independent, Sp1-dependent …
    262. SIRT1 alleviates senescence of degenerative human intervertebral disc cartilage endo-plate cells via the p53/p21 pathway
    263. CARF: an emerging regulator of p53 tumor suppressor and senescence pathway
    264. VentX trans-activates p53 and p16ink4a to regulate cellular senescence
    265. Caveolin-1/PTRF upregulation constitutes a mechanism for mediating p53-induced cellular senescence: implications for evidence-based therapy of delayed wound …
    266. Cooperation between p21 and Akt is required for p53‐dependent cellular senescence
    267. Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency
    268. Numb is required to prevent p53-dependent senescence following skeletal muscle injury
    269. RNA-binding protein FXR1 regulates p21 and TERC RNA to bypass p53-mediated cellular senescence in OSCC
    270. Overexpression of the pituitary tumor transforming gene induces p53-dependent senescence through activating DNA damage response pathway in normal human …
    271. Increased expression of SIRT2 is a novel marker of cellular senescence and is dependent on wild type p53 status
    272. Arsenite induces premature senescence via p53/p21 pathway as a result of DNA damage in human malignant glioblastoma cells
    273. Serpine 1 induces alveolar type II cell senescence through activating p53‐p21‐Rb pathway in fibrotic lung disease
    274. Senescence of bone marrow mesenchymal stromal cells is accompanied by activation of p53/p21 pathway in myelodysplastic syndromes
    275. Implication of p53-dependent cellular senescence related gene, TARSH in tumor suppression
    276. … inhibitors combined with retinoic acid can enhance differentiation of neuroblastoma cells and trigger ERK-and AKT-dependent, p53-independent senescence
    277. The effects of fucodian on senescence are controlled by the p16INK4a-pRb and p14Arf-p53 pathways in hepatocellular carcinoma and hepatic cell lines
    278. BS69 is involved in cellular senescence through the p53–p21Cip1 pathway
    279. Cellular and organismal ageing: Role of the p53 tumor suppressor protein in the induction of transient and terminal senescence
    280. Simvastatin rises reactive oxygen species levels and induces senescence in human melanoma cells by activation of p53/p21 pathway
    281. The p53-reactivating small molecule RITA induces senescence in head and neck cancer cells
    282. An indirect role for ASPP1 in limiting p53‐dependent p21 expression and cellular senescence
    283. Depletion of securin induces senescence after irradiation and enhances radiosensitivity in human cancer cells regardless of functional p53 expression
    284. … S6 kinase (RSK) inhibitor BI-D1870 prevents gamma irradiation-induced apoptosis and mediates senescence via RSK-and p53-independent accumulation of …
    285. Inhibitory effect of Lycium barbarum polysaccharides on cell apoptosis and senescence is potentially mediated by the p53 signaling pathway
    286. … anti-tumor mechanisms include Hsp60 post-translational modifications leading to the Hsp60/p53 complex dissociation and instauration of replicative senescence
    287. … secreted PDZ domain-containing protein 2 (sPDZD2) induces senescence or quiescence of prostate, breast and liver cancer cells via transcriptional activation of p53
    288. Silencing of protein kinase D2 induces glioma cell senescence via p53-dependent and-independent pathways
    289. Identification of p53-dependent genes potentially involved in UVB-mediated premature senescence of human skin fibroblasts using siRNA technology
    290. Suppression of the DHX9 helicase induces premature senescence in human diploid fibroblasts in a p53-dependent manner
    291. … -glycoside-A fraction of Gonolobus condurango induces DNA damage associated senescence and apoptosis via ROS-dependent p53 signalling pathway in HeLa …
    292. Engaging the p53 metabolic brake drives senescence
    293. NQO1 stabilizes p53 in response to oncogene-induced senescence
    294. Shikonin induces apoptosis, necrosis, and premature senescence of human A549 lung cancer cells through upregulation of p53 expression
    295. Preventive Effects of Epigallocatechin-3-O-Gallate against Replicative Senescence Associated with p53 Acetylation in Human Dermal Fibroblasts
    296. mTOR inactivation by ROS-JNK-p53 pathway plays an essential role in psedolaric acid B induced autophagy-dependent senescence in murine fibrosarcoma L929 …
    297. The matricellular protein CCN1 suppresses lung cancer cell growth by inducing senescence via the p53/p21 pathway
    298. Integrated stochastic model of DNA damage repair by non-homologous end joining and p53/p21-mediated early senescence signalling
    299. Diosmin-induced senescence, apoptosis and autophagy in breast cancer cells of different p53 status and ERK activity
    300. Cell-penetrating superoxide dismutase attenuates oxidative stress-induced senescence by regulating the p53-p21Cip1 pathway and restores osteoblastic …
    301. HJURP regulates cellular senescence in human fibroblasts and endothelial cells via a p53-dependent pathway
    302. pRB, p53, p16 INK4a, senescence and malignant transformation
    303. Centrosome aberrations associated with cellular senescence and p53 localization at supernumerary centrosomes
    304. TSH overcomes BrafV600E-induced senescence to promote tumor progression via downregulation of p53 expression in papillary thyroid cancer
    305. Truncated HBx‐dependent silencing of GAS2 promotes hepatocarcinogenesis through deregulation of cell cycle, senescence and p53‐mediated apoptosis
    306. Phospholipase D2 downregulation induces cellular senescence through a reactive oxygen species–p53–p21Cip1/WAF1 pathway
    307. miR-29c-3p promotes senescence of human mesenchymal stem cells by targeting CNOT6 through p53–p21 and p16–pRB pathways
    308. Mutant lamin A links prophase to a p53 independent senescence program
    309. CUL4B impedes stress-induced cellular senescence by dampening a p53-reactive oxygen species positive feedback loop
    310. CDK2 transcriptional repression is an essential effector in p53-dependent cellular senescence—implications for therapeutic intervention
    311. Soluble egg antigens of Schistosoma japonicum induce senescence in activated hepatic stellate cells by activation of the STAT3/p53/p21 pathway
    312. HBP1-mediated regulation of p21 protein through the Mdm2/p53 and TCF4/EZH2 pathways and its impact on cell senescence and tumorigenesis
    313. Δ133p53 represses p53-inducible senescence genes and enhances the generation of human induced pluripotent stem cells
    314. Estrogens decrease γ-ray–induced senescence and maintain cell cycle progression in breast cancer cells independently of p53
    315. Knockdown of MBP-1 in human foreskin fibroblasts induces p53-p21 dependent senescence
    316. Downregulation of Polo-like kinase 1 induces cellular senescence in human primary cells through a p53-dependent pathway
    317. Secreted protein acidic and rich in cysteine-induced cellular senescence in colorectal cancers in response to irinotecan is mediated by p53
    318. Activation of adenosine receptor A2A increases HSC proliferation and inhibits death and senescence by down-regulation of p53 and Rb
    319. p53 and senescence: a little goes a long way
    320. Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling …
    321. Foxp3 is a key downstream regulator of p53-mediated cellular senescence
    322. TWEAK increases SIRT1 expression and promotes p53 deacetylation affecting human hepatic stellate cell senescence
    323. Radiosensitization of prostate cancer by priming the wild-type p53-dependent cellular senescence pathway
    324. SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes
    325. p53 suppresses stress-induced cellular senescence via regulation of autophagy under the deprivation of serum
    326. The homeobox transcription factor Prox1 inhibits proliferation of hepatocellular carcinoma cells by inducing p53-dependent senescence-like phenotype
    327. ZEB1-induced tumourigenesis requires senescence inhibition via activation of DKK1/mutant p53/Mdm2/CtBP and repression of macroH2A1
    328. Activation of p53 contributes to pseudolaric acid B-induced senescence in human lung cancer cells in vitro
    329. CARF Regulates p19ARF‐p53‐p21WAF1 Senescence Pathway by Multiple Checkpoints
    330. Mithramycin depletes specificity protein 1 and activates p53 to mediate senescence and apoptosis of malignant pleural mesothelioma cells
    331. Egg antigen p40 of Schistosoma japonicum promotes senescence in activated hepatic stellate cells by activation of the STAT3/p53/p21 pathway
    332. Knockdown of CDK2AP1 in primary human fibroblasts induces p53 dependent senescence
    333. Cr (VI) induces premature senescence through ROS-mediated p53 pathway in L-02 hepatocytes
    334. COH-203, a novel microtubule inhibitor, exhibits potent anti-tumor activity via p53-dependent senescence in hepatocellular carcinoma
    335. Jekyll and Hyde, the p53 protein, pleiotropics antagonisms and the thrifty aged hypothesis of senescence
    336. Senescence evasion in melanoma progression: uncoupling of DNA‐damage signaling from p53 activation and p21 expression
    337. Cellular senescence regulated by SWI/SNF complex subunits through p53/p21 and p16/pRB pathway
    338. Resveratrol sequentially induces replication and oxidative stresses to drive p53-CXCR2 mediated cellular senescence in cancer cells
    339. mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53
    340. Regulation of the p19Arf/p53 pathway by histone acetylation underlies neural stem cell behavior in senescence‐prone SAMP8 mice
    341. p53 and ATF-2 partly mediate the overexpression of COX-2 in H2O2-induced premature senescence of human fibroblasts
    342. Cyclopentenyl cytosine induces senescence in breast cancer cells through the nucleolar stress response and activation of p53
    343. Inhibition of p53 prevents diabetic cardiomyopathy by preventing early-stage apoptosis and cell senescence, reduced glycolysis, and impaired angiogenesis
    344. Agmatine ameliorates high glucose-induced neuronal cell senescence by regulating the p21 and p53 signaling
    345. Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung …
    346. A novel cell-penetrating peptide derived from WT1 enhances p53 activity, induces cell senescence and displays antimelanoma activity in xeno-and syngeneic …
    347. An RNA interference screen for identifying downstream effectors of the p53 and pRB tumour suppressor pathways involved in senescence
    348. Identification of a DNA Damage–Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers
    349. Mitotic centromere-associated kinase (MCAK/Kif2C) regulates cellular senescence in human primary cells through a p53-dependent pathway
    350. Depletion of CSN5 inhibits Ras-mediated tumorigenesis by inducing premature senescence in p53-null cells
    351. A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM–p53 signaling
    352. The introduction of dominant-negative p53 mutants suppresses temperature shift-induced senescence in immortal human fibroblasts expressing a thermolabile SV40 …
    353. Loss of MECP2 leads to activation of p53 and neuronal senescence
    354. Cholesterol retards senescence in bone marrow mesenchymal stem cells by modulating autophagy and ROS/p53/p21Cip1/Waf1 pathway
    355. Identification and characterization of a potent activator of p53-independent cellular senescence via a small-molecule screen for modifiers of the integrated stress …
    356. … tumor cells and glioblastoma cell lines to N, N-bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines: cell death versus p53-independent senescence
    357. NORE1A is a double barreled Ras senescence effector that activates p53 and Rb
    358. p53-dependent downregulation of hTERT protein expression and telomerase activity induces senescence in lung cancer cells as a result of pterostilbene …
    359. … mTOR pathway inhibition and autophagy induction attenuates adriamycin-induced vascular smooth muscle cell senescence through decreased expressions of p53 …
    360. Cancer-associated S100P protein binds and inactivates p53, permits therapy-induced senescence and supports chemoresistance
    361. UBTD1 induces cellular senescence through an UBTD1–Mdm2/p53 positive feedback loop
    362. The suppressed proliferation and premature senescence by ganciclovir in p53-mutated human non-small-lung cancer cells acquiring herpes simplex virus-thymidine …
    363. Shifting p53-induced senescence to cell death by TIS21/BTG2/Pc3 gene through posttranslational modification of p53 protein
    364. p53 restoration in induction and maintenance of senescence: differential effects in premalignant and malignant tumor cells
    365. … mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic …
    366. The CEACAM1 tumor suppressor is an ATM and p53-regulated gene required for the induction of cellular senescence by DNA damage
    367. p53 in bronchial club cells facilitates chronic lung inflammation by promoting senescence
    368. A p53/ARF-dependent anticancer barrier activates senescence and blocks tumorigenesis without impacting apoptosis
    369. Regulation of cellular senescence via the FOXO4‐p53 axis
    370. Resistance of primary cultured mouse hepatic tumor cells to cellular senescence despite expression of p16Ink4a, p19Arf, p53, and p21Waf1/Cip1
    371. Suppression of senescence in normal human fibroblasts by introduction of dominant-negative p53 mutants or human papilloma virus type 16 E6 protein
    372. p53-dependent senescence in mesenchymal stem cells under chronic normoxia is potentiated by low-dose γ-irradiation
    373. Glutaredoxin-1 silencing induces cell senescence via p53/p21/p16 signaling axis
    374. Combined therapies that induce senescence and stabilize p53 block melanoma growth and prompt antitumor immune responses
    375. Aberrant anaplastic lymphoma kinase activity induces a p53 and RB-dependent senescence-like arrest in the absence of detectable p53 stabilization
    376. Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program
    377. p53 shares an antigenic determinant with proteins of 92 and 150 kilodaltons that may be involved in senescence of human cells.
    378. Mechanisms of cellular senescence by tumor suppressor p53
    379. Research advances on the relationship between cell senescence and oxidative stress, p16, p53/p 21
    380. Actin-binding doliculide causes premature senescence in p53 wild type cells
    381. MicroRNA-16 feedback loop with p53 and Wip1 can regulate cell fate determination between apoptosis and senescence in DNA damage response
    382. Inhibition of Twist1-mediated invasion by Chk2 promotes premature senescence in p53-defective cancer cells
    383. LncRNA‑mediated SIRT1/FoxO3a and SIRT1/p53 signaling pathways regulate type II alveolar epithelial cell senescence in patients with chronic obstructive …
    384. Downregulation of B‐myb promotes senescence via the ROS‐mediated p53/p21 pathway, in vascular endothelial cells
    385. SIRT1 reverses senescence via enhancing autophagy and attenuates oxidative stress-induced apoptosis through promoting p53 degradation
    386. Ectopic AP4 expression induces cellular senescence via activation of p53 in long-term confluent retinal pigment epithelial cells
    387. … Not Affect the Overexpression of p21WAF‐1 after Exposure of IMR‐90 hTERT Fibroblasts to a Sublethal Concentration of H2O2 Leading to Premature Senescence
    388. Cellular senescence in mouse hippocampus after irradiation and the role of p53 and p21
    389. The PPARγ‐SETD8 axis constitutes an epigenetic, p53‐independent checkpoint on p21‐mediated cellular senescence
    390. A simple stochastic model for the feedback circuit between p16INK4a and p53 mediated by p38MAPK: implications for senescence and apoptosis
    391. Senescence process in primary Wilms’ tumor cell culture induced by p53 independent p21 expression
    392. Hydroxylated-graphene quantum dots induce cells senescence in both p53-dependent and-independent manner
    393. Accumulation of smooth muscle 22α protein accelerates senescence of vascular smooth muscle cells via stabilization of p53 in vitro and in vivo
    394. Cytoplasmic E3 ubiquitin ligase CUL9 controls cell proliferation, senescence, apoptosis and genome integrity through p53
    395. Effect of lycium bararum polysaccharides on angiotensin II-induced senescence of human umbilical vein endothelial cells and expressions of p53 and P16
    396. Gallotannin is a DNA damaging compound that induces senescence independently of p53 and p21 in human colon cancer cells
    397. Tris (2-chloroethyl) phosphate induces senescence-like phenotype of hepatocytes via the p21Waf1/Cip1-Rb pathway in a p53-independent manner
    398. Activation of p53/p21waf1 pathway is associated with senescence during v-Ha-ras transformation of immortal C2C12 myoblasts.
    399. Cyclic mechanical tension reinforces DNA damage and activates the p53-p21-Rb pathway to induce premature senescence of nucleus pulposus cells
    400. p53 levels govern the choice between senescence and quiescence
    401. Acute loss of DP1, but not DP2, induces p53 mRNA and augments p21Waf1/Cip1 and senescence
    402. p53_growth_suppression.pdf#page=214″>Non-apoptotic responses to anticancer agents: Mitotic catastrophe, senescence and the role of p53 and p21
    403. Acute HSF1 depletion induces cellular senescence through the MDM2-p53-p21 pathway in human diploid fibroblasts
    404. Linking Nek6 to p53-induced senescence
    405. p41-Arc, a regulatory subunit of Arp2/3 complex, can induce premature senescence in the absence of p53 and Rb
    406. Effect of CCNB1 silencing on cell cycle, senescence, and apoptosis through the p53 signaling pathway in pancreatic cancer
    407. p53 shares an antigenic determinant with proteins of 92 and 150 kilodaltons that may be involved in senescence of human cells.
    408. Nore1a drives Ras to flick the p53 senescence switch
    409. Caveolin‑1 regulates oxidative stress‑induced senescence in nucleus pulposus cells primarily via the p53/p21 signaling pathway in vitro
    410. Hydrogen alleviates cellular senescence via regulation of ROS/p53/p21 pathway in bone marrow-derived mesenchymal stem cells in vivo
    411. Par-4-dependent p53 up-regulation plays a critical role in thymoquinone-induced cellular senescence in human malignant glioma cells
    412. Effect of silencing p53 and p21 on delaying senescence of nucleus pulposus cells
    413. Gadd45a gene silencing by RNAi promotes cell proliferation and inhibits apoptosis and senescence in skin squamous cell carcinoma through the p53 signaling …
    414. The imidazoacridinone C-1311 induces p53-dependent senescence or p53-independent apoptosis and sensitizes cancer cells to radiation
    415. LRP6 targeting suppresses gastric tumorigenesis via P14ARF–Mdm2–p53-dependent cellular senescence
    416. Immortalized mouse embryo fibroblasts are resistant to miR-290-induced senescence regardless of p53 status
    417. Correction: RNA-binding protein FXR1 regulates p21 and TERC RNA to bypass p53-mediated cellular senescence in OSCC
    418. Repeated stimulation by LPS promotes the senescence of DPSCs via TLR4/MyD88-NF-κB-p53/p21 signaling
    419. N-acetylcysteine ameliorates cisplatin-induced renal senescence and renal interstitial fibrosis through sirtuin1 activation and p53 deacetylation
    420. Role of p53-senescence induction in suppression of LNCaP prostate cancer growth by cardiotonic compound bufalin
    421. CSL-p53: From senescence to CAF activation
    422. Farnesyltransferase inhibitor induces p53-dependent cellular senescence in colon cancer cells
    423. PGE2 mediates senescence-induced inflammation in COPD lung fibroblasts via an EP2/p53 pathway
    424. Abstract B1: p53 isoforms, Δ133p53 and p53β, regulate aging-associated T lymphocyte senescence.
    425. The Influence of Overexpression of Wild Type p53 and UVB Radiation on Senescence of Human Skin Fibroblasts [J]
    426. Abstract A06: NORE1A is a double-barreled Ras senescence effector linking Ras to p53 and Rb
    427. Effect of microRNA-34a/SIRT1/p53 signal pathway on notoginsenoside R₁delaying vascular endothelial cell senescence
    428. Excess centrosomes induce p53-dependent senescence without DNA damage in endothelial cells
    429. Pharmacological DNA-PK inhibition induces ATM/p53 dependent premature senescence with immunomodulatory phenotype in irradiated cancer cells
    430. ASF1a inhibition induces p53-dependent growth arrest and senescence of cancer cells
    431. The p53/miRNAs/Ccna2 pathway serves as a novel regulator of cellular senescence: Complement of the canonical p53/p21 pathway
    432. … of human melanocytes to UVB twice and subsequent incubation leads to cellular senescence and senescence-associated pigmentation through the prolonged p53 …
    433. Differential radiation sensitivity in p53 wild-type and p53-deficient tumor cells associated with senescence but not apoptosis or (nonprotective) autophagy
    434. ALDH2 mediates the dose-response protection of chronic ethanol against endothelial senescence through SIRT1/p53 pathway
    435. Interleukin‑10 promotes primary rat hepatic stellate cell senescence by upregulating the expression levels of p53 and p21
    436. WITHDRAWN: Hexavalent chromium induces premature senescence through reactive oxygen species-mediated p53 pathway in L-02 hepatocytes
    437. Combined treatment with CCI779 and SB203580 induces cellular senescence in renal cell carcinoma cell line via p53 pathway
    438. Conjugated Physiological Resveratrol Metabolites Induce Senescence in Breast Cancer Cells: Role of p53/p21 and p16/Rb Pathways, and ABC Transporters
    439. Upregulation of MiR-126 Delays the Senescence of Human Glomerular Mesangial Cells Induced by High Glucose via Telomere-p53-p21-Rb Signaling Pathway
    440. Transcription of the tumor suppressor genes p53 and RB in lymphocytes from patients with chronic kidney disease: evidence of molecular senescence?
    441. … species induced by the compound bisphenol-a-diglycidylether cause senescence and apoptosis in colorectal cancer cell lines regardless of MDR1 or p53 …
    442. p53 restoration leads to tumor senescence and regression: implications for cancer therapy
    443. 23 SV40 oncoproteins and p53 deficiency impair stress-induced mesothelial cell senescence
    444. Senescence. Telomere, mitochondria and p53
    445. Methylseleninic acid super-activates p53 senescence axis as a preventive barrier to prostate tumorigenesis driven by Pten deficiency in vivo.
    446. p53 isoform delta133p53 in tumor senescence
    447. Comparative induction of p53-regulated gene expression by replicative senescence, pharmacological senescence, and DNA damage
    448. Inflammation, senescence and cancer: interweaving microRNA, inflammatory cytokines and p53 networks
    449. The role of Mip130/LIN-9, a cell cycle regulator, in the p19ARF/MDM2/p53 senescence pathway
    450. Role of mitochondria elongation in p53-induced cellular senescence
    451. Overexpression of MnSOD induces mitochondrial depolarization and p53-dependent senescence
    452. Critical roles of p53 and p16 in selenium-induced senescence
    453. Abstract A20: Excess centrosomes induce p53-dependent senescence in endothelial cells
    454. Cigarette Smoke Induces Cellular Senescence Via p53-Mediated Werner’s Syndrome Protein
    455. Abstract B30: Identification of new regulator in p53-mediated cellular senescence
    456. 1, 25‐Dihydroxyvitamin D exerts an antiaging role by activation of Nrf2‐antioxidant signaling and inactivation of p16/p53‐senescence signaling
    457. p53 gene expression is epigenetically regulated during replicative senescence in keratinocytes
    458. Inflammation, senescence and cancer: interweaving microRNA, inflammatory cytokines and p53 networks
    459. p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence
    460. Vitamin C inhibits p53-induced senescence by preventing ROS generation and p38 MAPKinase activation
    461. The role of p53 induced cellular senescence in age related disorders.
    462. Hyperoxic Exposure Increases Senescence in Type II-Like Mouse Lung Epithelial Cells: Role of p53 Signaling
    463. Rapid senescence induced by overexpression of p53 in NIH3T3 cells
    464. Abstract# SY15-4: Functions of p53 in cell senescence and survival
    465. CS-33DISCOVERY OF A p53-INDEPENDENT SUPPRESSOR OF SENESCENCE OF GLIOBLASTOMA MULTIFORME
    466. Transient p53-Mediated Regenerative Senescence in the Injured Heart
    467. Influence of RNA interference-induced repression of p53 expression on senescence in human skin fibroblasts
    468. SENP3 Postpones Cellular Senescence of p53-mediated Pathway under Mild Oxidative Stress
    469. p53-dependent, replicative cell senescence suppresses chronic hypoxia-Induced pulmonary hypertension in mice
    470. p53 action in apoptosis and senescence
    471. Activation of p53 by radiation and induction of senescence-like growth arrest
    472. The role of the p53 target Wig-1 in senescence and cancer
    473. p53-is-a-barrier-to-environmentalcarcinogenesis-37237.html”>Cellular Senescence Controlled by p53 is a Barrier to Environmental Carcinogenesis
    474. Abstract SY14-02: p53-mediated senescence impairs the apoptotic response to chemotherapy in breast cancer
    475. Molecular Mechanisms of p53-and ROS-induced senescence
    476. Abstract# 1702: Molecular basis for the accelerated senescence response to doxorubicin in p53 wild-type and p53 null/mutant breast tumor cells.
    477. Sirt1 antagonizes Stra13 Mediated p53 Acetylation and Senescence
    478. Role of p53 in Mammary Epithelial Cell Senescence
    479. Loss of Adipocyte MDM2 Causes Lipodystrophy by Inducing p53-Dependent Apoptosis and Senescence
    480. Supplemental Data Significant Role for p16INK4a in p53-Independent Telomere-Directed Senescence
    481. The p53-MDM2-Rb network in controlling cell growth, apoptosis and senescence
    482. TAp63 induces cellular senescence and blocks Ras-driven tumor formation through p53-depdendent and-indepdendent mechanisms
    483. The role of DEC1 in p53-dependent cellular senescence
    484. P19 ARF-p53 Tumor Suppressor Pathway During Oncogene-Induced Apoptosis and Senescence
    485. Differential efficacy of p53 restoration in induction and maintenance of senescence in premalignant and malignant cells
    486. p53 induces senescence in the unstable progeny of aneuploid cells
    487. Bisphenol A exposure under metabolic stress induces accelerated cellular senescence in vivo in a p53 independent manner
    488. Identification of novel p53-target genes and their physiological roles in tumor suppression and cellular senescence.
    489. A novel DNA damage-induced alternative splicing pathway that regulates p53 and cellular senescence markers
    490. Cellular Senescence Controlled by p53 is a Barrier to Environmental Carcinogenesis
    491. p53 restoration in liver carcinomas induces cellular senescence and tumor clearance through an innate immune response
    492. Modulating Effects and Mechanisms of p53-miR-34a-SIRT1 Feedback Loop on Reproductive Senescence of Vascular Endothelial Progenitor Cells
    493. Cellular senescence as a tumor suppressor mechanism is mediated by sequential activation of the p53 and RB pathways
    494. p53-dependent stromal senescence-induced tumor dormancy in the pre-metastatic reservoir thymus
    495. Genome–Epigenome–Senescence: Is TET1 a Caretaker of p53-Injured Lung Cancer Cells?
    496. … DECISIONS: SENESCENCE, REPAIR, AND REGENERATION: Plasminogen Activator Inhibitor-1 Induces Alveolar Type 2 Cell Senescence Through Activating p53 …
    497. Abstract A33: A whole genome RNAi screen identifies BRD7 and BAF180 as p53 regulators required for senescence
    498. Abstract PR08: Autophagic degradation of Δ133p53 during replicative cellular senescence: An isoform-specific protein degradation mechanism for p53
    499. Id4 acts as a tumor suppressor by inducing apoptosis and senescence in p53-dependent manner
    500. Overexpression of the 58-kDa microspherule protein (MSP58) triggers cellular senescence via the p53-p21 signaling axis
    501. ITGB 4 deficiency induces senescence of airway epithelial cells through p53 activation
    502. p53 induces senescence through Lamin A/C stabilization-mediated nuclear deformation
    503. Correction: NLRP6 targeting suppresses gastric tumorigenesis via P14ARF–Mdm2–p53-dependent cellular senescence
    504. The Mdm2-a splice variant alters development, lifespan, cellular growth and senescence in a p53-dependent manner
    505. Targeting NEK2 Induces Cellular Senescence in B-Cell Malignancies through p53-Independent Signaling Pathways
    506. Olaparib induced senescence under P16 or p53 dependent manner in ovarian cancer
    507. Synaptotagmin-7, a binding protein of p53, inhibits the senescence and promotes the tumorigenicity of lung cancer cells
    508. Plasminogen Activator Inhibitor-1 Induces Alveolar Type 2 Cell Senescence Through Activating p53-P21-Rb Pathways In Vitro And In Vivo
    509. Dissecting the function of p53 in cellular senescence by identification and characterization of p53 target genes
    510. CARF Regulates Cellular Senescence and Apoptosis through p53-Dependent and-Independent Pathways
    511. Loss of MECP2 leads to induction of p53 and cell senescence
    512. Susceptibility to Radiation Induced Apoptosis and Senescence in p53 Wild Type and p53 Mutant Breast Tumor Cells
    513. Coagulation Factor Xa Promotes Endothelial Cell Senescence Via p53 Up-regulation
    514. Abstract SY02-02: Tumor suppression in the absence of p53-mediated cell cycle arrest, apoptosis, and senescence.
    515. Notch Signaling Regulates Vascular Endothelial Cell Senescence via a p53-Dependent Pathway
    516. Chromatin interacting proteins RBL2/p130, MRG15 and p53 in cellular senescence
    517. p53 Isoforms in Cellular Senescence-and Ageing-Associated Biological and Physiological Functions
    518. Oncogene-induced senescence and the role of p53 in BRAFV600E melanoma
    519. Ionizing radiation-induced senescence of breast tumor cells is dependent on p53 and associated with telomere dysfunction.
    520. Sharp-1 Mediates p53-dependent cellular senescence through antagonism of Sirt1
    521. Hsp90β interacts with MDM2 to suppress p53‐dependent senescence during skeletal muscle regeneration
    522. p53 regulates mitochondrial dynamics by inhibiting Drp1 translocation into mitochondria during cellular senescence
    523. … RECEPTOR BLOCKER, FIMASARTAN REDUCES VASCULAR SMOOTH MUSCLE CELL SENESCENCE BY INHIBITING CYR61 AND ERK/P38MAPK/p53 …
    524. Abstract# 3478: Diminution of p53 during cellular senescence and organismal aging in normal human keratinocytes occurs at the post-transcriptional level
    525. MDM2-mediated degradation of WRN promotes cellular senescence in a p53-independent manner
    526. P4500 Cellular senescence of endothelial cells impairs angiogenesis by altering energy metabolism through p53-tigar axis
    527. Induction of p53 Dependent Cellular Senescence Through HdmX Inhibition or YPEL3 Expression
    528. TIS21/BTG2/PC3 triggers cancer cell death, instead of cellular senescence, by enhancing proapoptotic gene expression at the downstream of p53
    529. A retroviral tamoxifen-inducible human Tp53ER protein activates a conserved p53 response but fails to promote senescence in mouse fibroblasts
    530. Human colorectal cancer derived-MSCs promote tumor cells escape from senescence via p53/P21 pathway
    531. Depletion of GAPDH promotes p53 signaling, cell senescence and altered response to chemotherapeutic agents in human carcinoma cells
    532. In Cellular Senescence, the Third Circle of the Cell Life’s Network, p53 Acts Vital Role
    533. Induction of p53-mediated senescence is essential for the eventual anticancer therapeutic effect of RH1
    534. Abstract# 3473: Down regulation of HDAC2 in senescent fibroblasts involves cellular senescence through induction of p53 independent p21cip1/sdi1 transactivation
    535. TIS21 shifts p53-induced response of EJ bladder carcinoma cells from senescence to apoptosis
    536. Depletion of TRRAP induces p53‐independent senescence in liver cancer by downregulating mitotic genes
    537. 17β-estradiol inhibits human umbilical vascular endothelial cell senescence by regulating autophagy via p53
    538. The Kindlin2-p53-SerpinB2 signaling axis is required for cellular senescence in breast cancer
    539. Corrigendum: Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence …
    540. Abstract LB-082: The Kindlin2-p53-SerpinB2 signaling axis is required for the regulation of cellular senescence in breast cancer
    541. l-Carnitine inhibits the senescence-associated secretory phenotype of aging adipose tissue by JNK/p53 pathway
    542. ID: 1051 Telomerase activity, telomere length and p53 mutation detection on cellular senescence of Human Amnion Mesenchymal Stem Cells (HAMCs)
    543. Time-dependent p53 inhibition determines senescence attenuation and long-term outcome after renal ischemia-reperfusion
    544. The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1
    545. Influence of RNA interference in p53 gene on the expressions of genes involved in ultraviolet B-induced premature senescence and photocarcinogenesis in human …
    546. Involvement of p53 in senescence arrest and caspase 3 activity in the cell death response to methotrexate in the breast tumor cell
    547. Inhibition of DYRK1A-EGFR axis by p53-MDM2 cascade mediates the induction of cellular senescence
    548. … II-INDUCED CELLULAR SENESCENCE IN HUMAN CORONARY ARTERY SMOOTH MUSCLE CELLS BY INHIBITING CYR61 AND ERK/P38MAPK/p53 SIGNALING …
    549. … MECHANISMS THAT LINK AGING WITH LUNG DISEASE: THE CUTTING EDGE: Acrolein Induces p53-Mediated Cellular Senescence Accompanied By Enhanced …
    550. CALB1 enhances the interaction between p53 and MDM2, and inhibits the senescence of ovarian cancer cells
    551. Induction of a p21 mediated senescence program by p53 impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer
    552. Atrial Fibrillation Progression Is Associated with Cell Senescence Burden as Determined by p53 and p16 Expression
    553. Retraction: Interferon-β Induces Cellular Senescence in Cutaneous Human Papilloma Virus-Transformed Human Keratinocytes by Affecting p53 Transactivating …
    554. Possible role of cellular senescence in the pathogenesis of psoriasis–expression of 53BP1, γH2AX, p16, p21 and p53 in lesional psoriatic skin
    555. Methotrexate-induced senescence of human colon cancer cells depends on p53 acetylation, but not genomic aberrations
    556. BMI1 and dominant negative p53 cooperate to suppress AKT-mediated oncogene-induced senescence and promote transformation in human neural stem cells.
    557. PM 10 from Mexico City (MC) induce senescence-like phenotype and ATM, γH2A. X and p53 activation linked to oxidative stress
    558. Vascular Senescence Promotes the Development of Insulin Resistance: Role of Endothelial p53 in Glucose Metabolism
    559. Interleukin-10 induces senescence of activated hepatic stellate cells via STAT3-p53 pathway to attenuate liver fibrosis
    560. Decline of p300 contributes to cell senescence and growth inhibition of hUC-MSCs through p53/p21 signaling pathway
    561. P4239Bradykinin inhibits High Glucose-Induced Senescence of c-kit Positive Cardiac Stem Cells via B2R/PI3K/AKT/mTOR/p53 signal pathway
    562. Small molecule inhibitor of MDM2 induces p53-dependent HMGB1 secretion followed by apoptosis in cancer cells and incomplete senescence in normal fibroblasts
    563. Sirtuin 2 expression suppresses oxidative stress and senescence of nucleus pulposus cells through inhibition of the p53/p21 pathway
    564. circ LARP 4 induces cellular senescence through regulating miR‐761/RUNX 3/p53/p21 signaling in hepatocellular carcinoma
    565. 20 (S)-Ginsenoside Rg3 Promotes Senescence And Apoptosis In Gallbladder Cancer Cells Via The p53 Pathway [Corrigendum]
    566. Abstract A060: Inhibition of Aurora B kinase activity triggers senescence that can be bypassed by blocking p53 and RB function, promoting replication stress
    567. Wild-type p53-induced phosphatase 1 (Wip1) prevents cellular senescence at physiological oxygen levels by regulating DNA damage signaling during DNA …
    568. MicroRNA‐145 induces the senescence of activated hepatic stellate cells through the activation of p53 pathway by ZEB2
    569. Negative regulation of p53-induced senescence by N-WASP is crucial for DMBA/TPA-induced skin tumor formation
    570. Avenanthramide A Induces Cellular Senescence via miR-129-3p/Pirh2/p53 Signaling Pathway To Suppress Colon Cancer Growth
    571. Abstract P1-04-03: A Role for Cyclin D1 in Neoplastic Transformation in MCF-7 Breast Cancer Cells Post p14ARF-p53 Induced Senescence
    572. Mitotic catastrophe and p53-dependent senescence induction in T-cell malignancies exposed to nonlethal dosage of GL-V9
    573. Upregulation of the p53-p21 pathway by G2019S LRRK2 contributes to the cellular senescence and accumulation of α-synuclein
    574. p53 loss does not permit escape from BrafV600E-induced senescence in a mouse model of lung cancer
    575. Jun dimerization protein 2 controls hypoxia‐induced replicative senescence via both the p16Ink4a‐pRb and Arf‐p53 pathways
    576. Caveolin-1 mediated p53 activation in stress induced premature senescence and its antagonistic pleiotropic implications in cancer
    577. 0359: Cyclosporine A prevents the induction of replicative senescence in cultured coronary artery endothelial cells: role of eNOS-derived NO and the p53/p21 and p16 …
    578. The p53-p21 pathway is necessary for cellular senescence induced by the inhibition of protein kinase CKII in human colon cancer cells.
    579. TDF-ß signaling engages an ATM-CHK2-p53-independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial …
    580. Dephosphorylation of p53 Ser 392 Enhances Trimethylation of Histone H3 Lys 9 via SUV39h1 Stabilization in CK2 Downregulation-Mediated Senescence
    581. Supplemental Data Telomere Shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a
    582. Role of tea polyphenols in delaying hyperglycemia-induced senescence in human glomerular mesangial cells via miR-126/Akt–p53–p21 pathways
    583. The synergistic action of phosphate and interleukin-6 enhances senescence-associated calcification in vascular smooth muscle cells depending on p53
    584. Insulin-like growth factor-1 attenuates oxidative stress-induced hepatocyte premature senescence in liver fibrogenesis via regulating nuclear p53–progerin …
    585. Abstract C34: Senescence as a mechanism of resistance to the Aurora kinase and angiokinase inhibitor, ENMD-2076, in p53 mutated triple-negative breast cancer …
    586. C2-Ceramide-Induced Rb-Dominant Senescence-Like Phenotype Leads to Human Breast Cancer MCF-7 Escape from p53-Dependent Cell Death
    587. Loss of Cdh1 Triggers Premature Senescence in Part via Activation of Both the RB/E2F1 and the CLASPIN/CHK1/p53 Tumor Suppressor Pathways
    588. … anti-TOPO-1-containing sera from systemic sclerosis-related diseases with Raynaud’s phenomenon induce vascular endothelial cell senescence not via classical p53 …
    589. TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 …
    590. Roberson RS, Kussick SJ, Vallieres E, Chen SY, Wu DYEscape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in …
    591. Epigenetic regulation and molecular mechanisms of cellular senescence by tumor suppressor p53
    592. Editorial comment on ‘A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy’by Schmitt et al.
    593. However, cells that use Myc or loss of RB/p53 to circumvent senescence will eventually experience rampant genome instability due to the loss of their …
    594. Hyperglycemia-induced endothelial senescence mediated by the p53 deacetylase SIRT1 contributes to diabetic vasculopathy
    595. … EGFR and Mutant p53 Facilitates Epithelial-Mesenchymal Transition By Negating Oncogene-Activated Cellular Senescence in Transformed Human …
    596. OC-0050: Radiation-induced endothelial senescence is under the control of p53 and mitochondrial dysfunction
    597. Replicative Senescence of Human Oral Keratinocytes, Telomerase, Telomere, p53 and p21WAF¹/CIP¹
    598. P180 HEME OXYGENASE-1 PREVENTS VASCULAR SENESCENCE THROUGH MECHANISMS INVOLVING ROS/SIRT1/p53 PATHWAY IN AGED …
    599. Mo1744–Nlrp6 Targeting Suppresses Colonic Tumorigenesis Via p53-Dependent and Independent Cellular Senescence
    600. Sa1790 p53-Dependent Senescence Suppresses the Proliferation of Esophageal Epithelial Cells With Acetaldehyde-Derived DNA Damage
    601. Sa1715 Regulation of Cellular Senescence by the microRNA-34a/p53 Axis During Alcoholic Liver Injury
    602. Acrolein Induces p53-Mediated Cellular Senescence Accompanied By Enhanced Werner’s Syndrome Protein Degradation And Telomere Shortening
    603. H2O2 accelerates cellular senescence by accumulation of acetylated p53 via decrease in the function of SIRT1 by NAD [+] depletion
    604. Induction of Premature Senescence in Cardiomyocytes by Oxidative Stress Via PML-acetylated p53 Pathway in Cardiomyocytes
    605. p53 restoration in liver carcinomas induces cellular senescence and tumor clearance through an innate immune response
    606. CHIP ligase plays a central role in p53 regulation during senescence
    607. Altered expression of p53 ubiquitin ligases in human senescence
    608. 217 Localization of Phosphorylated H2AX and Phosphorylated p53 in Cells Inducing X-ray-induced Senescence-like Growth Arrest (Physics, chemistry …
    609. Telomere function and p16/RB and p53-mediated senescence pathways in human cancer
    610. Partial proteasome inhibition triggers p53-dependent premature senescence
    611. CARF is a novel regulator of p53 pathway that controls senescence and apoptosis
    612. RB and p53 Regulate Cell Proliferation, Cell Senescence and Apoptosis in Human Vascular Smooth Muscle Cells from Atherosclerotic Plaques
    613. ARF, p53 AND THE CONTROL OF CELLULAR SENESCENCE IN MOUSE MELANOCYTES.
    614. PJ-149 Hyperglycemia-induced Senescence of Endothelial Cells through the p53 Deacetylase SIRT1 (Diabetes/Obesity/Metabolic syndrome-10 (H) PJ25 …
    615. Protein Kinase CKII Inhibition-Induced Senescence is p53-Dependent
    616. … A Induces DNA Double Strand Break and Activates the ATM-p53-GDF15 Signaling Pathway Leading to Cell Cycle Arrest and Senescence in Human Fetal …
    617. FRS-071 Premature Senescence can be Induced by Oxidative Stress via PML-p53 Acetylation Pathway in Cardiomyocytes (Heart Failure Research (M) …
    618. mTOR directly phosphorylates p53 in PTEN-loss-induced cellular senescence
    619. ISDN2014_0058: p63 and p73 coordinate p53 function to determine the balance between survival, cell death and senescence in adult neural precursor …
    620. The relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescence
    621. GW29-e0204 Bradykinin Inhibits High-Glucose-Induced Senescence of Cardiac Progenitor Cells through the B2R/PI3K/AKT/mTOR/p53 Signal Pathways
    622. Senescence-related expression of p53 ligases
    623. Study on the mechanism of p53 family-mediated senescence= p53 단백질군에 의한세포노화의 기작에 관한 연구
    624. TIS21 shifts H-RasV12 oncogene-induced senescence to apoptosis in EJ bladder cancer cells in a p53 dependent manner
    625. p53 expression in the senescence induced with H2O2 in gastric epithelial cell
    626. Localization of Phosphorylated H2AX and Phosphorylated p53 in Cells Inducing X-ray-induced Senescence-like Growth Arrest
    627. Imidazoacridinone derivative C-1311 (SymadexTM) induces apoptosis, mitotic catastrophe or senescence in human colon carcinoma HCT116 cells depending on p53 …
    628. SCF (Fbxo22)-KDM4A targets methylated p53 for degradation and regulates senescence (細胞老化過程における p53 標的遺伝子 Fbxo22 の機能解析)< 内容の…
    629. 4-methyl-1-nitroacridine derivative C-1748 induces apoptosis, mitotic catastrophe or senescence in human colon carcinoma HCT116 cells depending on p53 status
    630. Transcriptional coactivator Sp110 associates with p53 and regulates p53-dependent cellular senescence
    631. Aging & Cellular Senescence: A Molecular Mechanism of p53-induced Senescence
    632. … and Cancer: RHI, a bioreductive agent exerts its anti-cancer effect through both apoptosis and senescence accompanied with marked induction of p53
    633. Akt Induces Endothelial Cell Senescence via a p53/p21-Dependent Pathway
    634. p53 codon 72 polymorphism and longevity: additional data on centenarians from continental Italy and Sardinia
    635. Why do centenarians escape or postpone cancer? The role of IGF-1, inflammation and p53
    636. p53 variants predisposing to cancer are present in healthy centenarians.
    637. Metabolic gene polymorphisms and p53 mutations in healthy centenarians and younger controls
    638. Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21‐dependent pathway
    639. New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53−/− mice by delaying carcinogenesis
    640. New tricks of an old molecule: lifespan regulation by p53
    641. p53/CEP‐1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress
    642. Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms
    643. Loss of p53 function accelerates acquisition of telomerase activity in indefinite lifespan human mammary epithelial cell lines
    644. Sequential extension of proliferative lifespan in human fibroblasts induced by over-expression of CDK4 or 6 and loss of p53 function
    645. Cockayne syndrome B protein (CSB): linking p53, HIF-1 and p300 to robustness, lifespan, cancer and cell fate decisions
    646. Systemic Akt1 deletion after tumor onset in p53−/− mice increases lifespan and regresses thymic lymphoma emulating p53 restoration
    647. Impaired p53/CEP‐1 is associated with lifespan extension through an age‐related imbalance in the energy metabolism of C. elegans
    648. The late effects of radiation on lifespan, lymphocyte proliferation and p53 haplodeficiency in mice
    649. Polμ deficiency induces moderate shortening of p53−/− mouse lifespan and modifies tumor spectrum
    650. The Mdm2-a splice variant alters development, lifespan, cellular growth and senescence in a p53-dependent manner
    651. Results-II. Haploinsufficiency of p53 Rescues Lifespan and Premature Aging-Associated Abnormalities in Sirt6-Deficient Mice
    652. AKT NEGATIVELY REGULATES HUMAN ENDOTHELIAL CELL LIFESPAN VIA THE p53/P21 DEPENDENT PATHWAY
    653. Akt negatively regulates the in vitro lifespan of human endothelial Cells via a p53/p21-dependent pathway
    654. The effects of p53 on whole organism longevity are mediated by autophagy
    655. p53: guardian AND suppressor of longevity?
    656. Tumor suppressor p53 Arg72Pro polymorphism and longevity, cancer survival, and risk of cancer in the general population
    657. The common germline Arg72Pro polymorphism of p53 and increased longevity in humans
    658. p53: Pro-aging or pro-longevity?
    659. The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor
    660. Reduced Expression of the Caenorhabditis elegans p53 Ortholog cep-1 Results in Increased Longevity
    661. The regulation of aging and longevity: a new and complex role of p53
    662. p53 codon 72 polymorphism and longevity: additional data on centenarians from continental Italy and Sardinia
    663. The p53–Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity
    664. Using mice to examine p53 functions in cancer, aging, and longevity
    665. Altered longevity‐assurance activity of p53: p44 in the mouse causes memory loss, neurodegeneration and premature death
    666. Lower antioxidant capacity and elevated p53 and p21 may be a link between gender disparity in renal telomere shortening, albuminuria, and longevity
    667. Rapamycin as longevity enhancer and cancer preventative agent in the context of p53 deficiency
    668. A role for p53 in mitochondrial stress response control of longevity in C. elegans
    669. Longevity regulation in flies: a role for p53
    670. CEP-1, the Caenorhabditis elegans p53 homolog, mediates opposing longevity outcomes in mitochondrial electron transport chain mutants
    671. Sir2 and longevity: the p53 connection
    672. P44, the ‘longevity‐assurance’isoform of p53, regulates tau phosphorylation and is activated in an age‐dependent fashion
    673. p53, longevity assurance and longevity suppression
    674. Transcription factors CEP‐1/p53 and CEH‐23 collaborate with AAK‐2/AMPK to modulate longevity in Caenorhabditis elegans.
    675. Germline genetics of the p53 pathway affect longevity in a gender specific manner
    676. Are the conspicuous interdependences of fecundity, longevity and cognitive abilities in humans caused in part by p53?
    677. A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models
    678. p53: Pro-aging or pro-longevity?
    679. The impact of p53 codon 72 SNP upon aging and longevity in mouse models
    680. Role of p53 in Extending Longevity in Untransformed Fibroblasts
    681. p53_Codon_72_Polymorphism_and_Longevity_20161220-25567-4p981f.pdf”>p53 Codon 72 Polymorphism and Longevity: Additional Data on Centenarians from Continental Italy and…
    682. On the discovery and elucidation of the mechanism via which repression of the Caenorhabditis elegans p53 ortholog cep-1 results in longevity.
    683. Sirtuin1, a longevity gene, is over-expressed and enhances proliferation and survival of endometrial carcinoma cells via deacetylation of p53.
    684. On the discovery and elucidation of the mechanism via whichrepression of the Caenorhabditis elegans p53 ortholog cep-1 results in longevity
    685. Elephants, longevity, cancer and p53
    686. Glutathione depletion induces antioxidant response via the p53-mediated transcription of PGC-1a: a novel longevity pathway?
    687. allintitle: p53 Aging: 195 results; 37 citations w/ no links provided: 158 Links
    688. Two faces of p53: aging and tumor suppression
    689. Senescence and aging: the critical roles of p53
    690. The p53 network: cellular and systemic DNA damage responses in aging and cancer
    691. Does p53 affect organismal aging?
    692. p53, ROS and senescence in the control of aging
    693. p53, oxidative stress, and aging
    694. Increased p53 protein associated with aging in human diploid fibroblasts
    695. Tumor suppression and normal aging in mice with constitutively high p53 activity
    696. The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging
    697. The Arf/p53 pathway in cancer and aging
    698. The tumor suppressor p53: cancer and aging
    699. Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform
    700. ATM‐dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post‐translational activation of p53 protein involving poly (ADP‐ribose) …
    701. Aging and chronic DNA damage response activate a regulatory pathway involving miR‐29 and p53
    702. Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program
    703. Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations
    704. From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: the telomere loss/DNA damage model of cell aging
    705. p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice
    706. p53: Pro-aging or pro-longevity?
    707. p53 as an intervention target for cancer and aging
    708. The regulation of aging and longevity: a new and complex role of p53
    709. DNA repair and aging: the impact of the p53 family
    710. Wnt/β-catenin signaling induces the aging of mesenchymal stem cells through the DNA damage response and the p53/p21 pathway
    711. Mdm2–p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin
    712. Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging
    713. p53 and aging: A fresh look at an old paradigm
    714. Accelerated development and aging of the immune system in p53-deficient mice
    715. Insights into aging obtained from p53 mutant mouse models
    716. Control of p53 and NF-κB signaling by WIP1 and MIF: role in cellular senescence and organismal aging
    717. Using mice to examine p53 functions in cancer, aging, and longevity
    718. p53 isoforms regulate aging-and tumor-associated replicative senescence in T lymphocytes
    719. Fragile fugue: p53 in aging, cancer and IGF signaling
    720. Complicating the role of p53 in aging
    721. Sun-exposure-and aging-dependent p53 protein accumulation results in growth advantage for tumour cells in carcinogenesis of nonmelanocytic skin cancer
    722. Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging
    723. Cancer and aging: yin, yang, and p53.
    724. Glycolysis links p53 function with NF‐κB signaling: Impact on cancer and aging process
    725. DNA sequence variants of p53: cancer and aging
    726. Aging-associated truncated form of p53 interacts with wild-type p53 and alters p53 stability, localization, and activity
    727. Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 3. Inhibitory effect of SkQ1 on tumor development from p53 …
    728. p53 induces skin aging by depleting Blimp1+ sebaceous gland cells
    729. Oxidative damage to DNA, p53 gene expression and p53 protein level in the process of aging in rat brain
    730. Aging splenocyte and thymocyte apoptosis is associated with enhanced expression of p53, bax, and caspase-3
    731. cep-1/p53-dependent dysplastic pathology of the aging C. elegans gonad
    732. p53 pro-oxidant activity in the central nervous system: implication in aging and neurodegenerative diseases
    733. Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging
    734. p53 mutations associated with aging-related rise in cancer incidence rates
    735. Pharmacogenetics and pharmagenomics, trends in normal and pathological aging studies: focus on p53
    736. Interaction between the Cockayne syndrome B and p53 proteins: implications for aging
    737. Recent discoveries in the cycling, growing and aging of the p53 field
    738. Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors
    739. It’s all about balance: p53 and aging
    740. Apurinic/apyrimidinic endonuclease 1, p53, and thioredoxin are linked in control of aging in C. elegans
    741. Anxiety and the aging brain: Stressed out over p53?
    742. Tumor suppression by p53 without accelerated aging: just enough of a good thing?
    743. Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner
    744. SnoN activates p53 directly to regulate aging and tumorigenesis
    745. Dysfunction of the MDM2/p53 axis is linked to premature aging
    746. Relationship of telomeres and p53 in aging bovine corneal endothelial cell cultures
    747. Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming
    748. Increased Arf/p53 activity in stem cells, aging and cancer
    749. Loss of androgen receptor in aging and oxidative stress through Myb protooncoprotein-regulated reciprocal chromatin dynamics of p53 and poly (ADP-ribose) …
    750. FGF21 represses cerebrovascular aging via improving mitochondrial biogenesis and inhibiting p53 signaling pathway in an AMPK-dependent manner
    751. Amelioration of premature aging in mtDNA mutator mouse by exercise: the interplay of oxidative stress, PGC-1α, p53, and DNA damage. A hypothesis
    752. Relevance of the p53–MDM2 axis to aging
    753. Multinucleated variant endothelial cells (MVECs) of human aorta: expression of tumor suppressor gene p53 and relationship to atherosclerosis and aging
    754. p53andaging-%20roleofp66Shc-%20impactaging.com%202013.pdf”>p53 and aging: role of p66Shc
    755. Control of cellular aging, tissue function, and cancer by p53 downstream of telomeres
    756. p53 and mouse aging models
    757. Modelling the p53/p66Shc aging pathway in the shortest living vertebrate Nothobranchius furzeri
    758. p53 isoforms regulate premature aging in human cells
    759. Altered S-nitrosylation of p53 is responsible for impaired antioxidant response in skeletal muscle during aging
    760. … expression of the p16 (INK4a)-Rb and p19 (Arf)-p53-p21 (Cip/Waf1) signaling pathways in the regulation of hematopoietic stem cell aging by ginsenoside Rg1
    761. p53 synthesis and phosphorylation in the aging diet-restricted rat following retinoic acid administration
    762. Delaying vascular aging with Chinese medicine: Implications from an overview of the p53 and miR-34s family
    763. Aging or tumor: The crosstalk between telomerase and p53
    764. The genetic architecture of aging: Sexual antagonistic plieotropy of p53 and foxo
    765. Transcription factor p53 and skin aging
    766. SirT3 and p53 deacetylation in aging and cancer
    767. Proliferative activity and expression of cyclin-dependent kinase inhibitor p21WAF1 and p53 protein in endothelial cells of human aorta during replicative aging in vitro
    768. p53-pathway.pdf”>USP22 down-regulation facilitates human retinoblastoma cell aging and apoptosis via inhibiting TERT/p53 pathway
    769. p53, sex, and aging: lessons from the fruit fly
    770. Apoptosis is induced in aging SV40 T antigen-transformed human fibroblasts through p53-and p21CIP1/WAF1-independent pathways
    771. Do p53 stress responses impact organismal aging?
    772. Yifuning postpones ovarian aging through antioxidant mechanisms and suppression of the Rb/p53 signal transduction pathway
    773. Dual signaling mechanisms of estrogen: Phosphorylation of p53 at Ser15 in aging HMEC in the absence of estrogen receptor
    774. Effect of Angelica sinensis polysaccharide on expression of telomere, telomerase and p53 in mice aging hematopoietic stem cells
    775. Commitment of protein p53 and amyloid-beta peptide (Aβ) in aging of human cerebellum
    776. A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models
    777. Therapeutic applications of p53 isoforms in regenerative medicine, aging and cancer
    778. Elevated levels of oxidative DNA damage activate p53 and caspases in brain of ayu with aging
    779. Influence of Electro-acupuncture of Yongquan-point on the Expression of p53 and bcl-2 in the Aging Model Rat Induced by D-dalactose
    780. The Dysfunctional MDM2–p53 Axis in Adipocytes Contributes to Aging-Related Metabolic Complications by Induction of Lipodystrophy
    781. DNA methylation and specific sequience motifs: association with genetics instability in p53 in cancer, and other loci in degenerative disorders and aging
    782. Between Scylla and Charybdis: p53 links tumor suppression and aging
    783. The p53 Pathway, Cancer and Aging
    784. Nervous System Aging, Degeneration, and the p53 Family
    785. DNA damage, p53 gene expression and p53 protein level in the rat brain aging
    786. Aging and p53: getting it straight A commentary on a recent paper by Gentry and Venkatachalam
    787. Therapeutic applications of p53 isoforms in regenerative medicine, aging and cancer
    788. EXPRESSIONS OF p53/Rb CELLULAR TRANSDUCTION PATHWAY RELATED GENES AND PROTEINS IN AGING RATS TESTES [J]
    789. p53-suppressed oncogene TET1 prevents cellular aging in lung cancer
    790. Abstract B1: p53 isoforms, Δ133p53 and p53β, regulate aging-associated T lymphocyte senescence.
    791. Therapeutic applications of p53 isoforms in regenerative medicine, aging and cancer
    792. Involvement of p53 and Bcl-2 in sensory cell degeneration in aging rat cochleae
    793. Effect of Heshouwuyin on Rb/p53 Signal Transduction Pathway in Brain Tissue Cells of Aging Rat [J]
    794. Moxibustion on Carbonyl Stress and Expression of p19ARF and p53 mRNA in Livers of D-galactose-Induced Aging Rats
    795. Polysaccharides from Athyrium multidentatum (Doll.) Ching an Attenuated d-Galactose-Induced Mouse Aging via SIRT1-p53-p21 Pathway
    796. It’s all about balance: p53 and aging
    797. Effect of Heshouwuyin on Rb/p53 signal transduction pathway in aging rat testis tissue cells
    798. Insights into stem cells and aging provided by a p53 mutant mouse
    799. p53: Pro-aging or pro-longevity?
    800. Unraveling the link between the Mdm2-p53 axis and aging
    801. p53 mediated transcription of Omi/HtrA2 in aging myocardium
    802. The role of p53 signaling pathway in aging and cancer
    803. An investigation of p53 in skeletal muscle aging
    804. Gene dosage and aging in lung tumorigenesis in p53 (273H) transgenic mice
    805. Cyclin D1 and p53 and their expression in human Leydig cells during aging
    806. The impact of p53 codon 72 SNP upon aging and longevity in mouse models
    807. The Effects of Ultraviolet Radiation on Aging and p53 Expression in Human Skin
    808. Silent information regulator 1 gene induces aging of hepatocellular carcinoma cells via p53/p21 pathway
    809. Role of telomere dysfunction, DNA damage response and p53 mutations in tumorigenesis and aging
    810. New Targets of p53 Regulation: From Aging to Immune Response
    811. Inhibition of Cytosolic p53 Preserves Mitochondrial Integrity and Prevents Cardiac Aging
    812. Estrogen-induced phosphorylation of p53 at Ser15 in aging HMEC in the absence of estrogen receptor
    813. Interleukin 6 Knockout Inhibits Aging-Related Accumulation of p53 in the Mouse Myocardium
    814. p53 Promotes Cardiac Aging Through The Inhibition Of Parkin Mediated Mitochondrial Quality Control
    815. Abstract# 596: p53 deletion impairs clearance of chromosomal instable stem cells and accelerates epithelial aging in telomere dysfunctional mice
    816. l-Carnitine inhibits the senescence-associated secretory phenotype of aging adipose tissue by JNK/p53 pathway
    817. Aging and DNA-damage response activate a regulatory pathway involving miR-29 and p53
    818. Results-II. Haploinsufficiency of p53 Rescues Lifespan and Premature Aging-Associated Abnormalities in Sirt6-Deficient Mice
    819. Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53
    820. Abstract# 3478: Diminution of p53 during cellular senescence and organismal aging in normal human keratinocytes occurs at the post-transcriptional level
    821. P1842 Repetitive postprandial glucose/triglyceride spikes activate p53 in bone marrow progenitor cells and induce premature aging of bone marrow
    822. p53 in metabolism, aging and cancer.
    823. THE ROLE OF THE p53/P66SHC PATHWAY IN DEVELOPMENT AND AGING: DANIO RERIO (ZEBRAFISH) AND NOTHOBRANCHIUS AS MODEL ORGANISMS
    824. Expression of Aβ42, τ-Protein, p16, p53 in Buccal Epithelium: Prospects for Use in the Diagnostics of Alzheimer’s Disease and Rate of Aging
    825. Influence of aging on the interaction of the PI3K survival pathway and the p53-mediated apoptosis pathway in a rat model of myocardial ischemia-reperfusion
    826. C21 MECHANISMS THAT LINK AGING WITH LUNG DISEASE: THE CUTTING EDGE: Acrolein Induces p53-Mediated Cellular Senescence Accompanied By …
    827. … plays a pivotal role in collateral development under ischemia by suppressing aging-induced production of oxidative stress, expression of p53 and pro-apoptotic …
    828. Cytotoxicity effects of tert-butyl hydroperoxide-induced p53-mediated cell-cycle arrest, apoptosis and aging in rat aortic endotheial cells and aorta: inhibition by …
    829. … Plays a Pivotal Role in Collateral Development Under Ischemia by Suppressing Aging-Induced Production of Oxidative Stress, Expression of p53 and Pro-Apoptotic …
    830. Effects of electroacupuncture of yongquan acupoint on the expression of p53 and bcl-2 in aging model rats
    831. Is p53 a key to understanding the distinction of aging process between normal human and rodent cells?
    832. Aging, p53 and the ’24 gene mutant’: getting it right A reply to Vijg and Hasty
    833. Mitochondrial DNA damage contributes to premature aging through p53-dependent response mechanisms
    834. TheHarlequinMouse Model of Premature Aging Displays Increased p53 Signalling, Evidence of Vascular Dysfunction and Inflammation in the Retina and …
    835. REGc DEFICIENCY PROMOTES PREMATURE AGING VIA A CK1D-MDM2-p53 PATHWAY
    836. The p53 family in neurodegeneration, aging, and neural stem cell function
    837. Mechanism of p53-mediated aging and metabolism
    838. < SYMPOSIUM: Biology of Aging and Age-associated Skin Disorders> TELOMERASE ACTIVITY, p53 VS BCL-2 EXPRESSION AND APOPTOSIS IN HUMAN SKIN …
    839. … act as a negative regulator of aging in human gingival fibroblast via p53 and Sp1 transcription factors= 히스톤 탈아세틸화 효소인 HDAC1 과 HSIR2 는 p53 과 Sp1 전사 …
    840. Aging and Cancer: RHI, a bioreductive agent exerts its anti-cancer effect through both apoptosis and senescence accompanied with marked induction of …
    841. Aging and Cancer: p53 mediated apoptosis
    842. Aging & Cellular Senescence: A Molecular Mechanism of p53-induced Senescence
    843. Aging and Cancer: Statin induces p53-dependent ER stress and apoptosis
    844. Aging and Cancer: Simvastatin induces ER stress-mediated apoptosis through enhancing p53 and Bax translocation to mitochondria
    845. Aging and Cancer: Activation of p53 by an antitumor antibiotic, ascochlorin, distinct from DNA damaging agents

     

    Share
    0
    Interstellar Blend
    Interstellar Blend

    Related posts

    October 6, 2020

    PPARY2


    Read more
    September 16, 2020

    NMDA & ANXIETY & DEPRESSION


    Read more
    September 16, 2020

    INFECTOBESITY


    Read more

    Comments are closed.

    Recent Posts

    • PPARY2
    • NMDA & ANXIETY & DEPRESSION
    • INFECTOBESITY
    • Anti-Acne effect of Flavonoids and Polyphenols
    • NOOTROPICS
    © 2021 Interstellar Blends | Activate Your Super Powers!. © 2019 Interstellar Blends | Activate Your Super Powers!. All Rights Reserved.

    Mandatory FDA Disclaimer
    Privacy Policy
    Terms and Conditions
    Have Questions?
    Contact Gavin Robert McGowen Here

    Join the following facebook groups to learn more:
    Ultimate Weightloss Challenge , Dry Fasting, Longevity Agents , Interstellar Blend Seven Sages, The Infinitely Postive, THE INTERSTELLAR BLEND CHALLENGE: Fluid Restricted Fasting w/ Superherbs

    Love this Website? Contact David Rodriguez to build you one!