CARBONYL SCAVENGER
February 2, 2022PUFAS
February 2, 2022- SIRT1 and insulin resistance
- The ups and downs of SIRT1
- SIRT1: recent lessons from mouse models
- Phosphorylation of HuR by Chk2 regulates SIRT1 expression
- Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity
- Phosphorylation regulates SIRT1 function
- Protective roles of SIRT1 in atherosclerosis
- Mammalian SIRT1: insights on its biological functions
- SIRT1 regulates aging and resistance to oxidative stress in the heart
- Mechanism of human SIRT1 activation by resveratrol
- JNK1 phosphorylates SIRT1 and promotes its enzymatic activity
- Regulation of SIRT1 in cellular functions: role of polyphenols
- Metabolic benefits from SIRT1 and SIRT1 activators
- A review of SIRT1 and SIRT1 modulators in cardiovascular and metabolic diseases
- SIRT1 is significantly elevated in mouse and human prostate cancer
- AMPK and SIRT1: a long-standing partnership?
- How does SIRT1 affect metabolism, senescence and cancer?
- Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
- SIRT1 and endocrine signaling
- DBC1 is a negative regulator of SIRT1
- SIRT1 and neuronal diseases
- SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1♦
- Tissue-specific regulation of SIRT1 by calorie restriction
- Shear stress, SIRT1, and vascular homeostasis
- JNK2-dependent regulation of SIRT1 protein stability
- SIRT1 regulates adipose tissue inflammation
- The critical role of the class III histone deacetylase SIRT1 in cancer
- SIRT1 controls endothelial angiogenic functions during vascular growth
- Function of the SIRT1 protein deacetylase in cancer
- SIRT1: roles in aging and cancer
- Cellular regulation of SIRT1
- A role for the NAD-dependent deacetylase SIRT1 in the regulation of autophagy
- Increase in activity during calorie restriction requires SIRT1
- Regulation of SIRT1 protein levels by nutrient availability
- A novel pathway regulates memory and plasticity via SIRT1 and miR-134
- SIRT1 is essential for normal cognitive function and synaptic plasticity
- Biochemical effects of SIRT1 activators
- Progressive loss of SIRT1 with cell cycle withdrawal
- Emerging roles of SIRT1 in vascular endothelial homeostasis
- SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence
- Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
- SIRT1, is it a tumor promoter or tumor suppressor?
- Metabolic adaptations through the PGC-1α and SIRT1 pathways
- Resveratrol is not a direct activator of SIRT1 enzyme activity
- Nutrient availability regulates SIRT1 through a forkhead-dependent pathway
- SIRT1 and p53, effect on cancer, senescence and beyond
- SIRT1 protects against high-fat diet-induced metabolic damage
- SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease
- Cytoplasm‐localized SIRT1 enhances apoptosis
- Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
- SIRT1 regulation of apoptosis of human chondrocytes
- Caloric restriction, SIRT1 and longevity
- Protective role of SIRT1 in diabetic vascular dysfunction
- Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
- Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival
- SIRT1 is a novel regulator of key pathways of human labor
- Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
- Expression and role of SIRT1 in hepatocellular carcinoma
- Brain SIRT1: anatomical distribution and regulation by energy availability
- Calorie restriction, SIRT1 and metabolism: understanding longevity
- Mammalian SIRT1 represses forkhead transcription factors
- Hormonal control of androgen receptor function through SIRT1
- SIRT1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
- SIRT1 transgenic mice show phenotypes resembling calorie restriction
- SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B
- SIRT1 shows no substrate specificity in vitro
- SIRT1 regulates energy metabolism and response to caloric restriction in mice
- SIRT1 modulation as a novel approach to the treatment of diseases of aging
- SIRT1 is an inhibitor of proliferation and tumor formation in colon cancer
- SIRT1 gain of function increases energy efficiency and prevents diabetes in mice
- Dietary activators of SIRT1
- miR-34a repression of SIRT1 regulates apoptosis
- SIRT1-null mice develop an autoimmune-like condition
- SIRT1: regulation of longevity via autophagy
- SIRT1 negatively regulates the mammalian target of rapamycin
- The interaction between FOXO and SIRT1: tipping the balance towards survival
- STAT3 inhibition of gluconeogenesis is downregulated by SIRT1
- SIRT1 stimulation by polyphenols is affected by their stability and metabolism
- Negative regulation of the deacetylase SIRT1 by DBC1
- SIRT1 improves healthy ageing and protects from metabolic syndrome-associated cancer
- SIRT1 modulates premature senescence-like phenotype in human endothelial cells
- Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration
- SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity
- Exercise training promotes SIRT1 activity in aged rats
- SIRT1 regulates the function of the Nijmegen breakage syndrome protein
- Interactions between E2F1 and SIRT1 regulate apoptotic response to DNA damage
- A c-Myc–SIRT1 feedback loop regulates cell growth and transformation
- The physiological roles of SIRT1 in skeletal muscle
- SIRT1 acts as a modulator of neointima formation following vascular injury in mice
- FoxO1 mediates an autofeedback loop regulating SIRT1 expression
- SIRT1 deacetylates and positively regulates the nuclear receptor LXR
- Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation
- Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
- Stabilization of Suv39H1 by SIRT1 is part of oxidative stress response and ensures genome protection
- SIRT1-mediated acute cardioprotection
- Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues
- SIRT1 regulates circadian clock gene expression through PER2 deacetylation
- SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes
- Role of SIRT1 in homologous recombination
- SIRT1 promotes differentiation of normal human keratinocytes
- SIRT1 as a potential therapeutic target for treatment of nonalcoholic fatty liver disease
- Inhibition of transcriptional activity of c-JUN by SIRT1
- Age‐associated loss of SIRT1‐mediated enhancement of glucose‐stimulated insulin secretion in beta cell‐specific SIRT1‐overexpressing (BESTO) mice
- Hypothalamic SIRT1 regulates food intake in a rodent model system
- Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress
- SIRT1 genetic variation is related to BMI and risk of obesity
- Modulation of SIRT1 expression in different neurodegenerative models and human pathologies
- Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation
- Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
- SIRT1: a metabolic master switch that modulates lifespan
- miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues
- SIRT1 contributes critically to the redox-dependent fate of neural progenitors
- A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells
- SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase
- Expression and prognostic significance of SIRT1 in ovarian epithelial tumours
- SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging
- The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
- A protein deacetylase SIRT1 is a negative regulator of metalloproteinase‐9
- SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase
- AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
- Controlling SIRT1 expression by microRNAs in health and metabolic disease
- Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1
- The anti-aging, metabolism potential of SIRT1.
- PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
- Strong expression of a longevity-related protein, SIRT1, in Bowen’s disease
- SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive
- SIRT1 activation protects the mouse renal medulla from oxidative injury
- SIRT1 Activation by Small Molecules: KINETIC AND BIOPHYSICAL EVIDENCE FOR DIRECT INTERACTION OF ENZYME AND ACTIVATOR♦
- SIRT1 regulates insulin secretion by repressing UCP2 in pancreatic β cells
- Function of SIRT1 in physiology
- SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis
- Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1
- SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism
- SIRT1 increases skeletal muscle precursor cell proliferation
- SIRT1 promotes DNA repair activity and deacetylation of Ku70
- Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle
- Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α
- SIRT1 regulates HIV transcription via Tat deacetylation
- DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1
- SIRT1 protects the heart from aging and stress
- SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1α
- SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis
- SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress
- Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation
- Human SIRT1 interacts with histone H1 and promotes formation of facultative heterochromatin
- Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells
- Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α
- Age related changes in NAD+ metabolism oxidative stress and SIRT1 activity in wistar rats
- The expression of SIRT1 in nonalcoholic fatty liver disease induced by high‐fat diet in rats
- SIRT1 deficiency attenuates spermatogenesis and germ cell function
- SIRT1 in muscle physiology and disease: lessons from mouse models
- SIRT1 involvement in rd10 mouse retinal degeneration
- High-intensity interval training increases SIRT1 activity in human skeletal muscle
- Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions
- Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma
- SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation
- Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma
- Association of SIRT1 gene variation with visceral obesity
- Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1
- Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice
- SIRT1 regulates UV-induced DNA repair through deacetylating XPA
- Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure
- Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis
- Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1
- Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress
- The role of SIRT1 in tumorigenesis
- Low SIRT1 expression, which is upregulated by fasting, in human adipose tissue from obese women
- SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/-mice
- The type III histone deacetylase SIRT1 is essential for maintenance of T cell tolerance in mice
- Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver
- Deacetylation of cortactin by SIRT1 promotes cell migration
- SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance
- SIRT1 gene is associated with major depressive disorder in the Japanese population
- SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress
- SIRT1 contributes to telomere maintenance and augments global homologous recombination
- Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation
- SIRT1 deacetylates APE1 and regulates cellular base excision repair
- Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage
- SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages
- Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-Lα
- SIRT1 acts in association with PPARα to protect the heart from hypertrophy, metabolic dysregulation, and inflammation
- SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents
- SIRT1 expression is associated with poor prognosis of diffuse large B-cell lymphoma
- SIRT1: tumor promoter or tumor suppressor?
- SIRT1 activation confers neuroprotection in experimental optic neuritis
- Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
- Resveratrol regulates human adipocyte number and function in a SIRT1-dependent manner
- SIRT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons
- Activation of SIRT1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells
- Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1
- Suppression of FOXO1 activity by FHL2 through SIRT1‐mediated deacetylation
- The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control
- Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction
- SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities
- Peptide switch is essential for SIRT1 deacetylase activity
- SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity
- Activation of SIRT1 by resveratrol inhibits TNF-α induced inflammation in fibroblasts
- SIRT1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression
- Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
- The direct involvement of SIRT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation
- Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase
- Physiological and pathophysiological functions of SIRT1
- Effect of chronic alcohol consumption on Hepatic SIRT1 and PGC-1α in rats
- SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1, 2 and HMGCS1, 2
- SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1
- Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction
- Roles of SIRT1 in the acute and restorative phases following induction of inflammation
- SIRT1 and AMPK in regulating mammalian senescence: a critical review and a working model
- Expression of SIRT1 in gastric cardiac cancer and its clinicopathologic significance
- SIRT1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction
- Modulation of SIRT1 by resveratrol and nicotinamide alters proliferation and differentiation of pig preadipocytes
- SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2
- The NAD World: a new systemic regulatory network for metabolism and aging—SIRT1, systemic NAD biosynthesis, and their importance
- Balance between SIRT1 and DBC1 expression is lost in breast cancer
- Enzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promoters
- Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein
- Resveratrol-activated AMPK/SIRT1/autophagy in cellular models of Parkinson’s disease
- Human SIRT1: a potential biomarker for tumorigenesis?
- RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10
- SIRT1 protects against microglia-dependent amyloid-β toxicity through inhibiting NF-κB signaling
- Overexpression of SIRT1 protects pancreatic β-cells against cytokine toxicity by suppressing the nuclear factor-κB signaling pathway
- SIRT1 is a circadian deacetylase for core clock components
- SIRT1-null mice develop tumors at normal rates but are poorly protected by resveratrol
- SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance
- SIRT1-dependent regulation of chromatin and transcription: linking NAD+ metabolism and signaling to the control of cellular functions
- SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1: possible role in AMP-activated protein kinase activation
- Distribution analysis of deacetylase SIRT1 in rodent and human nervous systems
- SIRT1 fails to affect p53‐mediated biological functions
- Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo
- High glucose downregulates endothelial progenitor cell number via SIRT1
- Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1
- SIRT1: linking adaptive cellular responses to aging-associated changes in organismal physiology
- SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells
- Neurogenesis directed by SIRT1
- Lysine deacetylation in ischaemic preconditioning: the role of SIRT1
- miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells
- SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization
- Regulation of cartilage-specific gene expression in human chondrocytes by SIRT1 and nicotinamide phosphoribosyltransferase
- Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage
- Kidney-specific overexpression of SIRT1 protects against acute kidney injury by retaining peroxisome function
- Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells
- Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations
- Resveratrol protects human endothelium from H2O2-induced oxidative stress and senescence via SIRT1 activation
- Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK–SIRT1–PGC-1α pathway
- Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C
- Roles of FoxO1 and SIRT1 in the central regulation of food intake
- SIRT1 is a redox‐sensitive deacetylase that is post‐translationally modified by oxidants and carbonyl stress
- Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation
- SIRT1 deacetylates c-Myc and promotes c-Myc/Max association
- Calorie restriction enhances cell adaptation to hypoxia through SIRT1-dependent mitochondrial autophagy in mouse aged kidney
- Translating cell survival and cell longevity into treatment strategies with SIRT1
- Deacetylation of FoxO by SIRT1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes
- Macrophage α1 AMP-activated protein kinase (α1AMPK) antagonizes fatty acid-induced inflammation through SIRT1
- The controversial links among calorie restriction, SIRT1, and resveratrol
- Resveratrol inhibits insulin responses in a SIRT1-independent pathway
- SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein α transcriptional complex
- SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly (ADP-ribose) polymerase 1
- The role of SIRT1: at the crossroad between promotion of longevity and protection against Alzheimer’s disease neuropathology
- Protein deacetylation by SIRT1: an emerging key post-translational modification in metabolic regulation
- Role of SIRT1 in regulation of LPS-or two ethanol metabolites-induced TNF-α production in cultured macrophage cell lines
- SIRT1 interacts with p73 and suppresses p73‐dependent transcriptional activity
- SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor α in breast cancer
- FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states
- Emerging roles of SIRT1 deacetylase in regulating cardiomyocyte survival and hypertrophy
- Role of sirtuin histone deacetylase SIRT1 in prostate cancer: a target for prostate cancer management via its inhibition?
- Resveratrol and neurodegenerative diseases: activation of SIRT1 as the potential pathway towards neuroprotection
- ΔNp63&alpha overexpression induces downregulation of SIRT1 and an accelerated aging phenotype in the mouse
- Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP
- Impact of SIRT1 on mammalian aging
- Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases
- SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism
- Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice
- A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development
- Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats
- The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD+
- SIRT1/eNOS axis as a potential target against vascular senescence, dysfunction and atherosclerosis
- PPARα-SIRT1 complex mediates cardiac hypertrophy and failure through suppression of the ERR transcriptional pathway
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- Hepatic SIRT1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance
- Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity
- SIRT1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras–MAPK signaling in human cancer cells
- Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the SIRT1 pathway
- SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells
- SIRT1 inhibits transforming growth factor β-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation
- SIRT1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling
- Melatonin, a novel SIRT1 inhibitor, imparts antiproliferative effects against prostate cancer in vitro in culture and in vivo in TRAMP model
- The SIRT1 deacetylase modulates the insulin-like growth factor signaling pathway in mammals
- SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60
- SIRT1 hyperexpression in SHR heart related to left ventricular hypertrophy
- Cigarette smoke-induced autophagy is regulated by SIRT1–PARP-1-dependent mechanism: implication in pathogenesis of COPD
- Relationship between SIRT1 expression and mitochondrial proteins during conditions of chronic muscle use and disuse
- Regulation of MEF2 by histone deacetylase 4-and SIRT1 deacetylase-mediated lysine modifications
- SIRT1 Gene, Age-Related Diseases, and Mortality: The Leiden 85-Plus Study
- Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype
- Interaction of aging-associated signaling cascades: Inhibition of NF-κB signaling by longevity factors FoxOs and SIRT1
- Modulations of hMOF autoacetylation by SIRT1 regulate hMOF recruitment and activities on the chromatin
- Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt
- Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island
- SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling
- Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells
- SIRT1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells
- PPARβ/δ regulates the human SIRT1 gene transcription via Sp1
- SIRT1 regulates oxidant-and cigarette smoke-induced eNOS acetylation in endothelial cells: role of resveratrol
- SIRT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats
- Cilostazol inhibits oxidative stress–induced premature senescence via upregulation of SIRT1 in human endothelial cells
- NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance
- SIRT1 and mir‐9 expression is regulated during glucose‐stimulated insulin secretion in pancreatic β‐islets
- SIRT1 modulates expression of matrix metalloproteinases in human dermal fibroblasts
- SIRT1 Is a Regulator of Bone Mass and a Repressor of Sost Encoding for Sclerostin, a Bone Formation Inhibitor
- Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1‐dependent adenosine monophosphate–activated kinase pathway
- Lack of SIRT1 (Mammalian Sirtuin 1) Activity Leads to Liver Steatosis in the SIRT1+/− Mice: A Role of Lipid Mobilization and Inflammation
- SIRT1 longevity factor suppresses NF‐κB‐driven immune responses: regulation of aging via NF‐κB acetylation?
- Resveratrol protects cardiomyocytes from hypoxia-induced apoptosis through the SIRT1–FoxO1 pathway
- SIRT1 takes a backseat to AMPK in the regulation of insulin sensitivity by resveratrol
- SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus
- Interference between PARPs and SIRT1: a novel approach to healthy ageing?
- Nuclear SIRT1 activity, but not protein content, regulates mitochondrial biogenesis in rat and human skeletal muscle
- Agrp neurons mediate SIRT1‘s action on the melanocortin system and energy balance: roles for SIRT1 in neuronal firing and synaptic plasticity
- Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands
- Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 inhibitors
- Control of multidrug resistance gene mdr1 and cancer resistance to chemotherapy by the longevity gene SIRT1
- Endurance exercise increases the SIRT1 and peroxisome proliferator-activated receptor γ coactivator-1α protein expressions in rat skeletal muscle
- Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice
- CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage
- SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity
- Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2
- CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability
- SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53
- Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1α expression in experimental stroke
- Metabolic regulation of SIRT1 transcription via a HIC1: CtBP corepressor complex
- Tumor necrosis factor α–mediated cleavage and inactivation of SIRT1 in human osteoarthritic chondrocytes
- Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SIRT1 expression
- Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIRT1
- Resveratrol improves oxidative stress and protects against diabetic nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1-independent pathway
- SIRT1: a novel target to prevent atherosclerosis
- SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse
- Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy
- Do we age on SIRT1 expression?
- SIRT1—a metabolic sensor that controls blood vessel growth
- Proatherogenic abnormalities of lipid metabolism in SIRT1 transgenic mice are mediated through Creb deacetylation
- Deacetylation of PGC-1α by SIRT1: importance for skeletal muscle function and exercise-induced mitochondrial biogenesis
- SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL
- SIRT1, stem cells, aging, and stem cell aging
- Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation
- SIRT1 negatively regulates HDAC1-dependent transcriptional repression by the RBP1 family of proteins
- Resveratrol promotes osteogenesis of human mesenchymal stem cells by upregulating RUNX2 gene expression via the SIRT1/FOXO3A axis
- The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation
- Role of p53 in the anti-proliferative effects of SIRT1 inhibition in prostate cancer cells
- C/EBPα regulates SIRT1 expression during adipogenesis
- The SIRT1 activator resveratrol protects SK‐N‐BE cells from oxidative stress and against toxicity caused by α‐synuclein or amyloid‐β (1‐42) peptide
- Activation of SIRT1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells
- SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53
- A role for SIRT1 in the hypoxic response
- Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation
- SIRT1 overexpression antagonizes cellular senescence with activated ERK/S6k1 signaling in human diploid fibroblasts
- Inhibition of SIRT1 deacetylase suppresses estrogen receptor signaling
- Role of NAD‐dependent deacetylases SIRT1 and SIRT2 in radiation and cisplatin‐induced cell death in vertebrate cells
- SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer
- Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients
- SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity
- Chromatin remodeling, metabolism and circadian clocks: the interplay of CLOCK and SIRT1
- SIRT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin‐like growth factor receptor …
- Dissecting systemic control of metabolism and aging in the NAD World: the importance of SIRT1 and NAMPT-mediated NAD biosynthesis
- Induction of endothelial nitric oxide synthase, SIRT1, and catalase by statins inhibits endothelial senescence through the Akt pathway
- SIRT1 plays an important role in mediating greater functionality of human ES/iPS-derived vascular endothelial cells
- Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice
- H2O2 accelerates cellular senescence by accumulation of acetylated p53 via decrease in the function of SIRT1 by NAD+ depletion
- SIRT1 modulates the estrogen–insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice
- Therapeutic potential of SIRT1 and NAMPT-mediated NAD biosynthesis in type 2 diabetes
- Antidiabetic activity of resveratrol, a known SIRT1 activator in a genetic model for type‐2 diabetes
- Nutrient-dependent regulation of PGC-1α’s acetylation state and metabolic function through the enzymatic activities of SIRT1/GCN5
- SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells
- Ionizing radiation induces cellular senescence of articular chondrocytes via negative regulation of SIRT1 by p38 kinase
- SIRT1 associates with eIF2-alpha and regulates the cellular stress response
- SIRT1 transcription is decreased in visceral adipose tissue of morbidly obese patients with severe hepatic steatosis
- SIRT1 confers protection against UVB‐ and H2O2‐induced cell death via modulation of p53 and JNK in cultured skin keratinocytes
- Comparative and pharmacophore model for deacetylase SIRT1
- Mediobasal hypothalamic SIRT1 is essential for resveratrol’s effects on insulin action in rats
- SIRT1 is involved in glucocorticoid-mediated control of uncoupling protein-3 gene transcription
- Induction of hypothalamic SIRT1 leads to cessation of feeding via agouti-related peptide
- SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability
- Changes in SIRT1 expression and its downstream pathways in age-related cataract in humans
- SIRT1 stabilizes PML promoting its sumoylation
- Aberrant cytoplasm localization and protein stability of SIRT1 is regulated by PI3K/IGF-1R signaling in human cancer cells
- The LXXLL motif of murine forkhead transcription factor FoxO1 mediates SIRT1-dependent transcriptional activity
- Effect of estrogens on bone marrow adipogenesis and SIRT1 in aging C57BL/6J mice
- Fasting promotes the expression of SIRT1, an NAD+-dependent protein deacetylase, via activation of PPARα in mice
- Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti‐aging and metabolic effects of sirtuins
- SIRT1 variants are associated with aging in a healthy Han Chinese population
- Stimulation of SIRT1-regulated FoxO protein function by the ligand-bound vitamin D receptor
- The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration
- The time of metabolism: NAD+, SIRT1, and the circadian clock
- SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) gene in skeletal muscle through the PGC-1α …
- The deacetylase enzyme SIRT1 is not associated with oxidative capacity in rat heart and skeletal muscle and its overexpression reduces mitochondrial biogenesis
- Silencing insulin resistance through SIRT1
- Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-κB pathways and inhibition of intracellular ROS/RNS …
- PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation
- Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor-induced neurite outgrowth in PC12 cells
- SIRT1 modulates aggregation and toxicity through deacetylation of the androgen receptor in cell models of SBMA
- SIRT1 inhibits angiotensin II-induced vascular smooth muscle cell hypertrophy
- Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via SIRT1–FOXO1 signaling pathway
- Erythropoietin employs cell longevity pathways of SIRT1 to foster endothelial vascular integrity during oxidant stress
- SIRT1 brings stemness closer to cancer and aging
- Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition
- The histone deacetylase SIRT1 controls male fertility in mice through regulation of hypothalamic-pituitary gonadotropin signaling
- Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E β-cells and human islets through a SIRT1-dependent mechanism
- … Prevents NAD+ Depletion and Protects Neurons Against Excitotoxicity and Cerebral Ischemia: NAD+ Consumption by SIRT1 may Endanger Energetically …
- SIRT1 markedly extends replicative lifespan if the NAD+ salvage pathway is enhanced
- Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1-and HEY2-mediated transcriptional repression
- Early apoptotic vascular signaling is determined by SIRT1 through nuclear shuttling, forkhead trafficking, bad, and mitochondrial caspase activation
- Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in mice through SIRT1-mediated deacetylation of p53
- Interactions between SIRT1 and AP-1 reveal a mechanistic insight into the growth promoting properties of alumina (Al 2 O 3 ) …
- SIRT1 is involved in energy metabolism: the role of chronic ethanol feeding and resveratrol
- MST1 promotes apoptosis through regulating SIRT1-dependent p53 deacetylation
- Role of SIRT1 in heat stress-and lipopolysaccharide-induced immune and defense gene expression in human dental pulp cells
- Tetrahydroxystilbene glucoside ameliorates diabetic nephropathy in rats: involvement of SIRT1 and TGF-β1 pathway
- Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide
- Nϵ-Thioacetyl-Lysine-Containing Tri-, Tetra-, and Pentapeptides as SIRT1 and SIRT2 Inhibitors
- SIRT1 regulation of wakefulness and senescence-like phenotype in wake neurons
- FoxO1 and SIRT1 regulate β-cell responses to nitric oxide
- Nicotinamide blocks proliferation and induces apoptosis of chronic lymphocytic leukemia cells through activation of the p53/miR-34a/SIRT1 tumor suppressor network
- Amurensin G, a potent natural SIRT1 inhibitor, rescues doxorubicin responsiveness via down-regulation of multidrug resistance 1
- Resveratrol is neuroprotective because it is not a direct activator of SIRT1—A hypothesis
- Resveratrol upregulated SIRT1, FOXO1, and adiponectin and downregulated PPARγ1–3 mRNA expression in human visceral adipocytes
- Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of SIRT1 in diabetic Wistar …
- Disruption of a SIRT1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation
- Expression changes in EZH2, but not in BMI-1, SIRT1, DNMT1 or DNMT3B are associated with DNA methylation changes in prostate cancer
- #VALUE!
- p16INK4a Suppression by Glucose Restriction Contributes to Human Cellular Lifespan Extension through SIRT1-Mediated Epigenetic and Genetic …
- Inhibition of SIRT1 promotes neural progenitors toward motoneuron differentiation from human embryonic stem cells
- Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats
- SIRT1 deficiency downregulates PTEN/JNK/FOXO1 pathway to block reactive oxygen species-induced apoptosis in mouse embryonic stem cells
- Downregulation of SIRT1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells
- SIRT1 is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type 2 diabetes in Pima Indians
- SIRT1 modulates high‐mobility group box 1‐induced osteoclastogenic cytokines in human periodontal ligament cells
- Aging and exercise affect the level of protein acetylation and SIRT1 activity in cerebellum of male rats
- SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome
- A functional link between SIRT1 deacetylase and NBS1 in DNA damage response
- SIRT1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor κB-mediated transcription
- Could SIRT1-mediated epigenetic effects contribute to the longevity response to dietary restriction and be mimicked by other dietary interventions?
- SIRT1 and caloric restriction: an insight into possible trade-offs between robustness and frailty
- Effects of dairy consumption on SIRT1 and mitochondrial biogenesis in adipocytes and muscle cells
- Induction of SIRT1 by mechanical stretch of skeletal muscle through the early response factor EGR1 triggers an antioxidative response
- SIRT1, neuronal cell survival and the insulin/IGF-1 aging paradox
- Distribution of the longevity gene product, SIRT1, in developing mouse organs
- A single-nucleotide variation in a p53-binding site affects nutrient-sensitive human SIRT1 expression
- Roles of SIRT1 in high glucose-induced endothelial impairment: association with diabetic atherosclerosis
- Activating SIRT1: a new strategy to prevent atherosclerosis?
- Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional …
- Basic leucine zipper transcription factor, ATF-like (BATF) regulates epigenetically and energetically effector CD8 T-cell differentiation via SIRT1 expression
- SIRT1 regulates Tat-induced HIV-1 transactivation through activating AMP-activated protein kinase
- SIRT1—a sensor for monitoring self-renewal and aging process in retinal stem cells
- Reciprocal roles of DBC1 and SIRT1 in regulating estrogen receptor α activity and co-activator synergy
- Transcriptional regulation of neuronal genes and its effect on neural functions: NAD-dependent histone deacetylase SIRT1 (Sir2α)
- Protective effects of resveratrol through the up-regulation of SIRT1 expression in the mutant hSOD1-G93A-bearing motor neuron-like cell culture model of amyotrophic …
- Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) …
- Metformin opposes impaired AMPK and SIRT1 function and deleterious changes in core clock protein expression in white adipose tissue of genetically‐obese db/db …
- SIRT1-independent mechanisms of the putative sirtuin enzyme activators SRT1720 and SRT2183
- SIRT1 gene, schizophrenia and bipolar disorder in the Japanese population: an association study
- Methyl donor deficiency induces cardiomyopathy through altered methylation/acetylation of PGC‐1α by PRMT1 and SIRT1
- FoxO-dependent and-independent mechanisms mediate SIRT1 effects on IGFBP-1 gene expression
- A novel chalcone polyphenol inhibits the deacetylase activity of SIRT1 and cell growth in HEK293T cells
- Transcription factor FOXL2 protects granulosa cells from stress and delays cell cycle: role of its regulation by the SIRT1 deacetylase
- Silibinin protects against isoproterenol-induced rat cardiac myocyte injury through mitochondrial pathway after up-regulation of SIRT1
- Genetic study between SIRT1, PPARD, PGC-1 α genes and Alzheimer’s disease
- SIRT1 controls circadian clock circuitry and promotes cell survival: a connection with age‐related neoplasms
- SIRT1, AMP-activated protein kinase phosphorylation and downstream kinases in response to a single bout of sprint exercise: influence of glucose ingestion
- Akt/FOXO3a/SIRT1-Mediated Cardioprotection by n-Tyrosol against Ischemic Stress in Rat in Vivo Model of Myocardial Infarction: Switching Gears toward Survival …
- Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation
- Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by SIRT1 and FoxO1
- Proteomic analyses of SIRT1-mediated cisplatin resistance in OSCC cell line
- AROuSing SIRT1: identification of a novel endogenous SIRT1 activator
- SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin
- Myristica fragrans Houtt. methanolic extract induces apoptosis in a human leukemia cell line through SIRT1 mRNA downregulation
- Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates β-catenin signaling and NFκB-specific transcription activity leading to MDR1 and Bcl-xL gene …
- Energy sensing factors PGC-1α and SIRT1 modulate PXR expression and function
- Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1‐independent sensitization to TRAIL‐induced apoptosis
- SIRT1, a calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications
- Simplification of the tetracyclic SIRT1-selective inhibitor MC2141: coumarin-and pyrimidine-based SIRT1/2 inhibitors with different selectivity profile
- SIRT1 links CIITA deacetylation to MHC II activation
- Phloroglucinol derivatives guttiferone G, aristoforin, and hyperforin: inhibitors of human sirtuins SIRT1 and SIRT2
- Resveratrol with antioxidant activity inhibits matrix metalloproteinase via modulation of SIRT1 in human fibrosarcoma cells
- Overexpression of SIRT1 in mouse forebrain impairs lipid/glucose metabolism and motor function
- Structure-based design of pseudopeptidic inhibitors for SIRT1 and SIRT2
- SIRT1 regulates tyrosine hydroxylase expression and differentiation of neuroblastoma cells via FOXO3a
- SIRT1 regulates thyroid-stimulating hormone release by enhancing PIP5Kγ activity through deacetylation of specific lysine residues in mammals
- SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention–the TULIP Study
- The type III histone deacetylase SIRT1 protein suppresses p300-mediated histone H3 lysine 56 acetylation at Bclaf1 promoter to inhibit T cell activation
- Resveratrol inhibition of inducible nitric oxide synthase in skeletal muscle involves AMPK but not SIRT1
- Dual role of Zn2+ in maintaining structural integrity and suppressing deacetylase activity of SIRT1
- Resveratrol prevents antibody-induced apoptotic death of retinal cells through upregulation of SIRT1 and Ku70
- NO targets SIRT1: a novel signaling network in endothelial senescence
- Low-frequency electroacupuncture improves insulin sensitivity in obese diabetic mice through activation of SIRT1/PGC-1 in skeletal muscle
- SIRT1 regulates the ribosomal DNA locus: epigenetic candles twinkle longevity in the Christmas tree
- Delivery of Oct4 and SIRT1 with cationic polyurethanes-short branch PEI to aged retinal pigment epithelium
- SIRT1 physically interacts with Tip60 and negatively regulates Tip60-mediated acetylation of H2AX
- Resveratrol-activated SIRT1 in liver and pancreatic β-cells: a Janus head looking to the same direction of metabolic homeostasis
- PARP-2 regulates SIRT1 expression and whole-body energy expenditure
- Involvement of the p65/RelA subunit of NF-κB in TNF-α-induced SIRT1 expression in vascular smooth muscle cells
- Effects of resveratrol on NO secretion stimulated by insulin and its dependence on SIRT1 in high glucose cultured endothelial cells
- BCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repression
- Interactions between DBC1 and SIRT1 are deregulated in breast cancer cells
- SIRT1 top 40 hits: use of one-bead, one-compound acetyl-peptide libraries and quantum dots to probe deacetylase specificity
- SIRT1 and SIRT5 activity expression and behavioral responses to calorie restriction
- Aberrant expression pattern of histone acetylation modifiers and mitigation of lupus by SIRT1-siRNA in MRL/lpr mice
- Acute and long-term nutrient-led modifications of gene expression: potential role of SIRT1 as a central co-ordinator of short and longer-term programming of tissue …
- Activation of SIRT1 by resveratrol represses transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) by deacetylating hepatic …
- SIRT1: a guardian at the gates of adipose tissue inflammation
- Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear receptor estrogen receptor-related receptor γ transactivation
- Oncogenic viral protein HPV E7 up-regulates the SIRT1 longevity protein in human cervical cancer cells
- Mthfr deficiency induces endothelial progenitor cell senescence via uncoupling of eNOS and downregulation of SIRT1
- The role of SIRT1 in renal rejuvenation and resistance to stress
- Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity
- Tat-SIRT1 tango
- Deleted in breast cancer–1 regulates SIRT1 activity and contributes to high-fat diet–induced liver steatosis in mice
- Reciprocal roles of SIRT1 and SKIP in the regulation of RAR activity: implication in the retinoic acid-induced neuronal differentiation of P19 cells
- Transcriptional activation of NAD+-dependent protein deacetylase SIRT1 by nuclear receptor TLX
- Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation
- Interactions between dietary vitamin E intake and SIRT1 genetic variation influence body mass index
- A fluorometric assay of SIRT1 deacetylation activity through quantification of nicotinamide adenine dinucleotide
- Upregulation of SIRT1 deacetylase in phenylephrine-treated cardiomyoblasts
- Serum withdrawal up‐regulates human SIRT1 gene expression in a p53‐dependent manner
- Hexosamines stimulate apoptosis by altering SIRT1 action and levels in rodent pancreatic β-cells.
- Expression and localization of Werner syndrome protein is modulated by SIRT1 and PML
- Nicotinamide phosphoribosyltransferase is essential for interleukin-1β-mediated dedifferentiation of articular chondrocytes via SIRT1 and extracellular signal …
- Ambient glucose levels qualify the potency of insulin myogenic actions by regulating SIRT1 and FoxO3a in C2C12 myocytes
- Limited role of SIRT1 in cancer protection by dietary restriction
- Zyxin is a novel interacting partner for SIRT1
- Influence of aging and hemorrhage injury on SIRT1 expression: possible role of myc-SIRT1 regulation in mitochondrial function
- From heterochromatin islands to the NAD World: a hierarchical view of aging through the functions of mammalian SIRT1 and systemic NAD biosynthesis
- Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the α-myosin heavy chain expression
- Is SIRT1 a miracle bullet for longevity?
- Nε-Modified lysine containing inhibitors for SIRT1 and SIRT2
- … receptor β/δ (PPARβ/δ) agonist GW501516 prevents TNF-α-induced NF-κB activation in human HaCaT cells by reducing p65 acetylation through AMPK and SIRT1
- Role of SIRT1-FoxO1 signaling in dietary saturated fat-dependent upregulation of liver adiponectin receptor 2 in ethanol-administered mice
- Does hypothalamic SIRT1 regulate aging?
- Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1
- Activation of the SIRT1 pathway and modulation of the cell cycle were involved in silymarin’s protection against UV-induced A375-S2 cell apoptosis
- WldS enhances insulin transcription and secretion via a SIRT1-dependent pathway and improves glucose homeostasis
- Metabolic signals regulate SIRT1 expression
- Old drug acquires new target: metformin and SIRT1
- Resveratrol induces SIRT1-and energy–stress-independent inhibition of tumor cell regrowth after low-dose platinum treatment
- MiR-34, SIRT1, and p53: the feedback loop
- Food restriction improves glucose and lipid metabolism through SIRT1 expression: a study using a new rat model with obesity and severe hypertension
- Does LKB1 mediate activation of hepatic AMP-protein kinase (AMPK) and sirtuin1 (SIRT1) after Roux-en-Y gastric bypass in obese rats?
- Calorie restriction and obesity under the regulation of SIRT1
- Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SIRT1 activity
- Resveratrol (trans‐3, 5, 4′‐trihydroxystilbene) suppresses EL4 tumor growth by induction of apoptosis involving reciprocal regulation of SIRT1 and NF‐κB
- SIRT1 performs a balancing act on the tight-rope toward longevity
- p53 deacetylation by SIRT1 decreases during protein kinase CKII downregulation-mediated cellular senescence
- SIRT1 deficiency attenuates MPP+-induced apoptosis in dopaminergic cells
- Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca 2+ and AMPK/SIRT1
- SIRT1 protein levels in cancer: Tuning SIRT1 to the needs of a cancer cell
- Human SIRT1 associates with mitotic chromatin and contributes to chromosomal condensation
- Red wine triggers cell death and thioredoxin reductase inhibition: effects beyond resveratrol and SIRT1
- Peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis
- CBP/p300 and SIRT1 are involved in transcriptional regulation of S-phase specific histone genes
- Regulatory role of SIRT1 on the gene expression of fatty acid‐binding protein 3 in cultured porcine adipocytes
- Effects of caloric restriction on SIRT1 expression and apoptosis of islet beta cells in type 2 diabetic rats
- Restriction of advanced glycation end products improves insulin resistance in human type 2 diabetes: potential role of AGER1 and SIRT1
- Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity
- MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating SIRT1
- Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1
- Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors
- Is systemic activation of SIRT1 beneficial for ageing-associated metabolic disorders?
- TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SIRT1
- Poly (ADP-ribose) polymerase-2 depletion reduces doxorubicin-induced damage through SIRT1 induction
- Red wine decreases asymmetric dimethylarginine via SIRT1 induction in human endothelial cells
- Anticancer Effects of 15d-Prostaglandin-J2 in Wild-Type and Doxorubicin-Resistant Ovarian Cancer Cells: Novel Actions on SIRT1 and HDAC
- Pharmacophore mapping and virtual screening for SIRT1 activators
- Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1)
- Sirtuin 1 (SIRT1) the misunderstood HDAC
- Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1
- Substrate specificity of SIRT1-catalyzed lysine Nε-deacetylation reaction probed with the side chain modified Nε-acetyl-lysine analogs
- Reduced expression of SIRT1 is associated with diminished glucose-induced insulin secretion in islets from calorie-restricted rats
- Decreased SIRT1 deacetylase activity in sporadic inclusion-body myositis muscle fibers
- … peroxisome proliferator-activated receptor γ regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in …
- MicroRNA 132 regulates nutritional stress-induced chemokine production through repression of SIRT1
- Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and SIRT1
- A nutrient‐sensitive interaction between SIRT1 and HNF‐1α regulates Crp expression
- High dose of dietary resveratrol enhances insulin sensitivity in healthy rats but does not lead to metabolite concentrations effective for SIRT1 expression
- Dual targeting of the antagonistic pathways mediated by SIRT1 and TXNIP as a putative approach to enhance the efficacy of anti-aging interventions
- Cisplatin induces SIRT1 in association with histone deacetylation and increased Werner syndrome protein in the kidney
- Determinants of serum-induced SIRT1 expression in older men: the CHAMP study
- Roles of SIRT1 and phosphoinositide 3-OH kinase/protein kinase C pathways in evodiamine-induced human melanoma A375-S2 cell death
- Anti-aging protein SIRT1: A role in cervical cancer?
- SIRT1 deacetylase activity and the maintenance of protein homeostasis in response to stress: an overview
- Dysregulation of Myeloid‐specific Transcription Factors in Congenital Neutropenia: Rescue by NAMPT/NAD+/SIRT1
- SIRT1 inhibitory diterpenoids from the Vietnamese medicinal plant Croton tonkinensis
- Impact of 6-mo caloric restriction on myocardial ischemic tolerance: possible involvement of nitric oxide-dependent increase in nuclear SIRT1
- The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO
- Comparative deacetylase activity of wild type and mutants of SIRT1
- Discovery of oxazolo [4, 5-b] pyridines and related heterocyclic analogs as novel SIRT1 activators
- SIRT1, notch and stem cell” age asymmetry”
- Glucagon-like peptide 1 inhibits the sirtuin deacetylase SIRT1 to stimulate pancreatic β-cell mass expansion
- PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity
- Protection by EGb 761 against β-amyloid-induced neurotoxicity: involvement of NF-κB, SIRT1, and MAPKs pathways and inhibition of amyloid fibril formation
- Resveratrol inhibited Tat-induced HIV-1 LTR transactivation via NAD+-dependent SIRT1 activity
- Discovery of Imidazo[1,2-b]thiazole Derivatives as Novel SIRT1 Activators
- Regulated expression of neuronal SIRT1 and related genes by aging and neuronal β2-containing nicotinic cholinergic receptors
- Measurement of the cellular deacetylase activity of SIRT1 on p53 via LanthaScreen® technology
- A novel role of SIRT1 in sildenafil induced cardioprotection in mice
- p53-, SIRT1-, and PARP-1-independent downregulation of p21WAF1 expression in nicotinamide-treated cells
- Decreased SIRT1 expression and LKB1 phosphorylation occur with long-term high-fat diet feeding, in addition to AMPK phosphorylation impairment in the early phase
- Effects of calorie restriction on SIRT1 expression in liver of nonalcoholic fatty liver disease: experiment with rats
- Silencing metabolic disorders by novel SIRT1 activators
- WldS Reduces Paraquat-Induced Cytotoxicity via SIRT1 in Non-Neuronal Cells by Attenuating the Depletion of NAD
- Ethanol extracts of black pepper or turmeric down-regulated SIRT1 protein expression in Daudi culture cells
- High fat diet increases and the polyphenol, S17834, decreases acetylation of the SIRT1-dependent lysine-382 on p53 and apoptotic signaling in …
- Effects of resveratrol on pig primary preadipocytes proliferation, differentiation and transcription expression of SIRT1 gene
- SIRT1 promotes DNA damage repair and cellular survival
- Effect of 40% restriction of dietary amino acids (except methionine) on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver
- Negative regulation of stress‐induced matrix metalloproteinase‐9 by SIRT1 in skin tissue
- Leptin gene transfer regulates fibromuscular development and lipid deposition in muscles via SIRT1, FOXO3a and PGC-1α in mice in vivo
- A biotin switch-based proteomics approach identifies 14-3-3ζ as a target of SIRT1 in the metabolic regulation of caspase-2
- Functional interplay between Parp-1 and SIRT1 in genome integrity and chromatin-based processes
- Correction: Corrigendum: SIRT1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
- Intra-arterial targeted islet-specific expression of SIRT1 protects β cells from streptozotocin-induced apoptosis in mice
- Poly (ADP‐ribose) polymerase 1 is involved in glucose toxicity through SIRT1 modulation in HepG2 hepatocytes
- SIRT1 as a key regulator orchestrating the response to caloric restriction
- Isolation of megastigmane sesquiterpenes from the silkworm (Bombyx mori L.) droppings and their promotion activity on HO-1 and SIRT1
- SIRT1 Activation Mediates Sildenafil-Induced Cardioprotection Against Ischemia/Reperfusion Injury in Mice
- Effects of baicalin against oxidative stress injury of SH-SY5Y cells by up-regulating SIRT1
- … acid B protects beta-cells from cytokine-induced apoptosis by alleviating apoptotic pathways and activating anti-apoptotic pathways of Nrf2–HO-1 and SIRT1
- SIRT1 as a new therapeutic target in metabolic and age-related diseases
- EVI1 up-regulates the stress responsive gene SIRT1 which triggers deacetylation and degradation of EVI1
- Real-time fluorescence imaging of SIRT1 cytosolic translocation under the treatment of growth factor deprivation
- SIRT1, p53 and mitotic chromosomes
- High-affinity Na+-dependent dicarboxylate cotransporter promotes cellular senescence by inhibiting SIRT1
- #VALUE!
- Bone and calcium update; diagnosis and therapy of bone metabolism disease update. Regulatory Mechanism of Mammalian Sirtuin SIRT1 in Vascular calcification …
- Effects of 2-deoxyglucose and dehydroepiandrosterone on intracellular NAD+ level, SIRT1 activity and replicative lifespan of human Hs68 cells
- No significant association between SIRT1 gene and methamphetamine‐induced psychosis in the Japanese population
- Myocardial SIRT1 expression following endurance and resistance exercise training in young and old rats
- SIRT1 and neurodegenerative diseases
- Targeting SIRT1-a multitasker
- Genetic and expression analysis of the SIRT1 gene in gastric cancers
- Insulin downregulates SIRT1 and AMPK activation and is associated with changes in liver fat, but not in inflammation and mitochondrial oxidative capacity, in …
- Resveratrol (trans-3, 5, 4′-trihydroxystilbene) induces SIRT1 and down-regulates NF-κB activation to abrogate DSS-induced colitis
- Identification of single nucleotide polymorphisms of SCD and SIRT1 and evaluation of their genetic diversities in chickens
- Not miR-ly aging: SIRT1 boosts memory via a microRNA-dependent mechanism
- Inhibition of SIRT1 increases EZH2 protein level and enhances the repression of EZH2 on target gene expression
- Effect of SIRT1 gene on cardiac function and life
- SIRT1 enhances survival of human osteoarthritic chondrocytes by repressing PTP1B and activating the IGF receptor pathway
- Mechanism of apoptosis induced by SIRT1 deacetylase inhibitors in human breast cancer MCF-7 drug-resistant cells
- Nicotinamide, a Recognized Inhibitor of SIRT1, Promotes Expansion in Ex Vivo Cultures of Short and Long-Term Repopulating Cells.
- SIRT1 inhibits IL-1β mRNA transcription in lipopolysaccharide tolerant THP-1 cells
- Effect of resveratrol derivative BTM-0512 on high glucose-induced dysfunction of endothelial cells: role of SIRT1
- SIRT1 increases satellite cell cycle progression
- 3D-QSAR of SIRT1 activators targeting against diet-induced metabolic syndrome
- Research progression of deacetylase (SIRT1)
- Disruption of Igfbp1 fails to rescue the phenotype of SIRT1−/− mice
- iNOS inactivates SIRT1, a key regulator of stress resistance and metabolism, by S-Nitrosylation
- Abstract SY11-03: SIRT1 transgenic and cancer models
- Effects of resveratrol on SIRT1 expression, eNOS activity and NO secretion of hyperlipid cultured HUVEC
- SIRT1: a novel adipocyte and myocyte regulatory factor
- Toward productive aging: SIRT1, systemic NAD biosynthesis, and the NAD world
- Expression of SIRT1 in primary human uveal melanoma
- Involvement of SIRT1 in mouse myocardial hypertrophy induced by isorenin [J]
- Modeling miRNA regulation in signaling networks: miR-34a regulation of the p53/SIRT1 module
- SIRT1 regulates bone mass in vivo through regulation of osteoblast and osteoclast differentiation
- The antioxidative role of SIRT1/PGC-1α pathway in Parkinson disease
- SIRT1 activators promote p65 deacetylation and suppress TNFa stimulated NF‐kB activation
- Trans-resveratrol inhibits phosphorylation of Smad2/3 and represses FSHβ gene expression by a SIRT1-independent pathway in LβT2 gonadotrope cells
- Overexpression of SIRT1, a Longevity Gene-Encoded Protein, and Induction of Apoptosis by Its Inhibition In Adult T-Cell Leukemia Cells
- #VALUE!
- SIRT1 expression in adult acute leukemia and its clinical significance [J]
- Overexpression of the Sirtuin SIRT1 Increases Insulin Sensitivity in Aging Mice.
- Development of Fluorescent Quantitative PCR Assay for Porcine SIRT1 Gene
- Nox4 regulates cellular survival by modulating FoxO3a activity and SIRT1 expression
- Neuroprotective mechanisms of SIRT1
- Mechanism of SIRT1 acting on tumor formation
- SIRT1, a Stress-responsive Deacetylase is Required for Development of Compensatory Cardiac Hypertrophy
- The race to control aging and diseases: Sir2/SIRT1 against Ras, TOR and Akt/S6K
- SIRT1 overexpression modifies cardiac energy metabolism
- SIRT1 activator SRT1720 suppresses inflammatory reaction in OVA-induced asthma model mouse
- SIRT1 is not required for exercise‐induced mitochondrial biogenesis, but maintains basal organelle content and function
- Both the Activity and Stability of the Transcriptional Repressor PLZF Are Modified by the Class III Histone Deacetylase SIRT1.
- Long-Term Calorie Restriction increases SIRT1 expression and Inhibits Vascular Senescence in Mice
- Reduced SIRT1 leads to increased Th2 cytokine expression via hyper-acetylation of GATA3
- SIRT1 and adult stem cell senescence
- Mechanism of regulating deacetylase SIRT1 expression and activity.
- SIRT1 Deficiency Suppresses the Maintenance of Hematopoietic Stem Cell Pool.
- SIRT1, a Longevity Gene Encoded Protein, Regulates Apoptosis of Adult T-Cell Leukemia Cells and Its Inhibition by Sirtinol Induces Apoptosis.
- The Longevity Factor SIRT1 Protects Heart from Ischemia/Reperfusion Stress
- SIRT1 and Ku70 expression in acute leukemia and its clinical significance
- SIRT1 regulates human vascular smooth muscle cell Lifespan
- Upregulation of SIRT1 protects lens epithelial cells in oxidative conditions and cataract formation in humans
- Role of SIRT1 in Proliferation and Self-Renewal of Mouse Embryonic Stem Cells.
- SIRT1 controls endothelial angiogenic functions during vascular growth and maturation
- SIRT1 diminishes atherogenesis by suppressing NF-kB signaling-mediated pro-inflammatory events
- Role of SIRT1 histone deacetylase in melanoma: A target for melanoma management via its inhibition
- Abstract# 4441: c-Myc/SIRT1 feedback loop: A novel regulation of c-Myc induced cellular transformation
- SIRT1 overexpression in pancreatic adenocarcinomas correlates with shortened patient survival and small molecule inhibition as well as target knockdown of SIRT1 …
- Caloric restriction and SIRT1 modulate APP metabolism in vitro and in vivo
- Nuclear shuttling of SIRT1 is associated with caloric restriction-induced cardioprotection
- In silico evidence supports a role for DNA methylation in SIRT1-mediated effects of dietary restriction
- Regulation of translation and transcription by SIRT1: Potential novel mechanisms for regulating stress response and aging
- Treatment with the SIRT1 activator SRT1720 reduces large elastic artery stiffness, superoxide production and inflammation in old mice
- SIRT1 Activators Attenuate Retinal Ganglion Cell Loss During Acute Optic Neuritis
- BDNF-deficiency downregulates SIRT1 and upregulates SIRT2 expression in aging mouse retina
- Chronic treatment with SIRT1 activator SRT1720 ameliorates age-associated vascular endothelial dysfunction in B6D2F1 mice
- SIRT1 inhibition induces apoptosis in human CML progenitors by enhancing p53 acetylation and activation
- A novel SIRT1 activator SIRT1720 triggers in vitro and in vivo cytotoxicity in multiple myeloma via ATM-dependent mechanism
- SIRT1-Mediated Deacetylation Promotes Akt Membrane Localization and Activation During Development of Cardiac Hypertrophy.
- The Role of SIRT1 in Reproduction.
- SIRT1 Regulates PTEN/Akt/FOXO1 Pathway to Trigger ROS-Induced Apoptosis In Mouse Embryonic Stem Cells.
- Pharmacological inhibition of the stress-related deacetylase SIRT1 enhances eradication of cml stem cells
- SIRT1 modulates foxo-dependent transcription and prevents smooth muscle cell apoptosis in response to oxidative stress
- SIRT1 and Heart Disease [J]
- SIRT1 takes down tumors
- Study on the clinicopathologic significance and expression of SIRT1
- Brain space for SIRT1
- SIRT1 and Tumorigenesis
- Resveratrol, an Activator of Protein Deacetylase SIRT1, Suppresses Oxidative Stress-Induced Cell Death by Upregulating MnSOD Expression through Transactivation …
- SIRT1 keeps escapees quiet
- SIRT1 in transcription regulation
- Significance of SIRT1 expression in breast cancer
- The SIRT1 Activator Resveratrol Suppresses Cardiomyocyte Hypertrophy by Promoting Histone H3 Lys9 Deacetylation and Tri-methylation
- Response to Gomez-Cabrera et al: update on SIRT1 signaling
- SIRT1 and cell migration
- Abstract# 5092: Inhibition of SIRT1 by sirtinol causes p53-independent activation of FoxO1 in human prostate cancer cells.
- Inhibition of FoxO1-SIRT1 Signaling by Sustained Acetylation of PGC-1 Alpha Promotes Angiotensin II-Induced Vascular Senescence
- Expression and significance of SIRT1 in breast cancer with diabetes meilitus
- SIRT1 and neoplasms
- Abstract# 4126: SIRT1 is required for normal prostate gland development and androgen signaling in vivo
- Evidence for a Common Mechanism of SIRT1 Regulation by
- The skinny on SIRT1 regulation
- SIRT1 and neoplasms.
- The regulatory effect of SIRT1 on CⅡTA under hypoxia
- 152. Involvement of Trp53 in SIRT1 function during embryo development
- Identification of DNA Targets for SIRT1 in Human Cells
- Authentic SIRT1 activators? No, for Sirtin
- SIRT1 Gene Eukaryotic Eexpression of SD Rat
- SIRT1 Fluorometric Drug Discovery Kit
- Protective Roles of SIRT1 in Vascular Diseases
- SIRT1 Phosphorylation and Cell Proliferation
- Effect of SIRT1 on insulin secretion in MIN6 cell line and its mechanism
- SIRT1 Rabbit Polyclonal Antibody
- The Correlation of SIRT1 and Skin Senescence
- A potential tumor suppressive role of SIRT1 in Cancer
- Nuclear SIRT1 activity regulates oxidative capacity
- SIRT1 Regulates Notch4 Signaling In Endothelial Cells
- SIRT1 promotes DNA repair activity in response to radiation
- The Regulation of SIRT1 in Endocrine and Metabolism
- Effects of dairy consumption on SIRT1 and metabolic risk in humans
- Inhibition of SIRT1 Catalytic Activity
- SIRT1 promotes differentiation of normal human keratinocytes
- SIRT1, metabolism and calorie restriction
- The role of SIRT1 in restricted energy intake
- Expression and significance of SIRT1 in breast cancer with diabetes mellitus
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- Expression of SIRT1 in Retinoblastoma: A Potential Therapeutic Target
- Cancer Connection: Tumor-fighter throttles life-extending protein SIRT1
- Identification of a novel SIRT1/FEN1 interaction and their regulation by karyopherins
- SIRT1 DIMINISHES ATHEROGENESIS BY SUPPRESSING NF-‐ΚB SIGNALING-‐MEDIATED PRO-‐INFLAMMATORY EVENTS
- The SIRT1 mRNA expression in human intervertebral disc
- SIRT1 Involvement in Mouse and Human Retinal Development and Function
- miR-200a targets SIRT1 for malignant transformation
- The Role of SIRT1 in Resveratrol Toxicity
- Role of SIRT1 in Smooth Muscle Cell Function and Vascular Remodeling
- SIRT1 enhances drug resistance of CML K562 cells
- On the role of TLR2 and SIRT1 in the development of diabetes mellitus
- Effect of SIRT1 on the Transcription of HIV-1 Induced by Tat
- Abstract B46: Essential roles of SIRT1 for BCR‐ABL transformation and genetic mutations
- Effects of CR on H_2O_2-Induced Stress Injury and Expression of SIRT1 in PC12 Cells
- The SIRT1 Inhibitor Tenovin-6 Induces Monocytic Differentiation in APL Cells
- SIRT1 Gene Silencing: A Potential Therapeutic Strategy for Pancreatic Cancer
- Molecular mechanisms of a disease susceptibility variant of SIRT1: Genotoxic stress‐induced, CTCF‐dependent activation of SIRT1 gene expression
- Deficiency Of SIRT1 Enhances Elastase-induced Emphysema In Mice
- SIRT1 ACTIVATION SEEMS TO PROMOTE APOPTOSIS OF HUMAN OSTEOSARCOMA CELLS
- Characterization of the role of SIRT1 and its potential as a chemotherapeutic target in breast cancer
- SIRT1 Regulates the Mouse Gastric Emptying and Intestinal Growth
- Roles of SIRT1 in neuronal oxidative damage and brain function
- Negative Regulation of STAT3-mediated Cellular Respiration by SIRT1
- SIRT1 Inhibits VSMC Proliferation and Migration Underlying Neointima Formation Following Vascular Injury
- Effects of calorie restriction on expression of SIRT1 and SIRT2
- SIRT1 modulates E2/ERα-associated oncogenic signaling in human breast cancer
- The Research Progression of NAD~+, Nampt and SIRT1 [J]
- Phosphorylation of Thr522 activates SIRT1 and is required for DYRK‐mediated cell survival in response to DNA damage
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- Establishment of Stable SIRT1 Gene-Downregulated Hepatocarcinoma Cell Lines by Lentiviral Vector
- Constitutive SIRT1 Overexpression Impairs Mitochondrial Function in Mice
- SIRT1 deacetylation regulates NFAT transcriptional activity
- Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells
- FoxO1 Mediates an Auto-feedback Loop Regulation of SIRT1 Expression
- PPARalpha-SIRT1 Complex Mediates Metabolic Adaptation in Response to Starvation in the Heart
- Effects of silencing SIRT1 gene expression on proliferation and apoptosis of pancreatic cancer cell line PANC1
- SIRT1 Is Critical for Pdx1 Transcription and β‐Cell Formation
- Th lf Si t1 i The role of SIRT1 in restricted energy intake
- Involvement of SIRT1 in ultraviolet radiation mediated damages and transformation of skin keratinocytes
- SIRT1 Regulates Hyperglycemia-Induced Vascular Senescence
- Expressions of SIRT1 as prognostic biomarker on resectable gastric cancer patient
- Expression of SIRT1 during axonal degeneration by NAD.
- Muscle‐Specific Disruption of SIRT1 Reduces Mitochondrial Function and Increases Reactive Oxygen Species Production
- SIRT1 Is Required for Mouse Embroyonic Stem Cell Commitment to Hematopoietic Cell Differentiation.
- Expression of SIRT1 mRNA in abdominal aorta in rats with spontaneous type 2 diabetic mellitus
- Growth factor deprivation induces cytosolic translocation of SIRT1
- SIRT1 Mediates Pressure Overload-Induced Cardiac Hypertrophy and Failure in vivo
- SIRT1-Dependent and-Independent Effects of Resveratrol on Cardiovascular Oxidative Stress
- Nutrient and hormonal control of the protein deacetylase SIRT1
- The Development of Choroidal Neovascular Membranes in Patients With AMD Is a SIRT1-Independent Process
- SIRT1 Activation Affects the Transmission of Photoperiodic Information by Melatonin
- SIRT1 and AMPK: the Seesaw Effect in Regulating Endothelial Sene-scence
- Effect of SIRT1 and telomerase on stem cells
- Histone deacetylase SIRT1 promotes the differentiation of P19CL6 cells into cardiomyocytes
- Research Progress of the Nonalcoholic Fatty Liver Based on the SIRT1 Target Spot
- SIRT1 REGULATES CIGARETTE SMOKE-MEDIATED IMPAIRMENT OF ENDOTHELIAL CELL SIGNALING
- The pro-apoptotic effect of vitamin C on colon cancer cell lines, HCT116 via the regulation of SIRT1 expression (165.11)
- Stress and survival: Possible role of SIRT1 in the diencephalon during fasting
- Role of the longevity gene hSir2 (SIRT1) in cancer resistance to chemotherapy
- SIRT1 Decreases Lox-1 Mediated Foam Cell Formation in Atherogenesis
- Transcriptional control of glucose homeostasis through SIRT1 and PGC-1alpha
- HIGH LEVELS OF E-SELECTIN ARE ASSOCIATED WITH A REDUCTION OF SIRT1 EXPRESSION IN LYMPHOMONOCYTES FROM SUBJECTS WITH METABOLIC …
- SIRT1 Overexpression Modulates Cardiac Metabolic Genes Expression and Induces Dilated Cardiomyopathy
- Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators
- Resveratrol upregulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights
- Overexpression of SIRT1 and induction of apoptosis by its inhibition in adult T-cell leukemia cells
- Investigation on SIRT1 in Peripheral Blood Mononuclear Cell (PBMC) and Relationship with Pathogenesis of Psoriasis
- Primary study on the association of expression between SIRT1 and FOXO1 in B cells of islet in rat.
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- Regulation of the NAD+‐dependent histone deacetylase SIRT1 in conditions of muscle use and disuse
- Regulation of SIRT1 protein in cancer metabolism and ribosome biogenesis
- Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction
- Characterization and investigation of seven SIRT proteins in human cell aging: down-regulation of SIRT1 extends cellular lifespan
- Role of SIRT1 and Sirt6 Expression in the Pathophysiology of the rd10 Mouse Retinal Degeneration
- Alcohol consumption and Western style diet alter colonic SIRT1 gene expression during aging
- SIRT1 is expressed in prostatic adenocarcinomas and increases tumor cell invasion when overexpressed in DU145 cells
- SIRT1 Stabilizes PML promoting its Sumoylation
- Transcription Regulator SIRT1 Protects Choroidal Endothelial Cells from Oxidative Stress
- Effects of resveratrol on cardiomyocyte apoptosis induced by anoxia and the expression of SIRT1
- Modulation of Angiogenesis and Postnatal Vascular Growth by the NAD-Dependent Histone Deacetylase SIRT1
- SIRT1 Activation Restores Cardioprotection in the Aged Heart Against Ischemia/Reperfusion Injury
- PPARalpha-SIRT1 Complex Downregulates Mitochondrial Gene Expression Through Suppression of the ERR Response Element in the Heart Under Pressure …
- Selenoprotein S Suppression Enhances the Late Stage Differentiation of Proerythrocytes Via SIRT1
- The Longevity Factor SIRT1 Exacerbates LV Dysfunction and Energy Depletion in Response to Pressure Overload
- SIRT1 represses MMP13 expression in human articular chondrocytes.
- The role of TNFα in circadian rhythmic responses and regulation of metabolic regulator SIRT1 in liver
- Effects of CR on H2O2-induced stress injury and expression of SIRT1 in PC12 cells.
- Aging and vascular endothelial cell senescence: potential role of SIRT1 in development of inflammation and dysfunction
- Abstract P233: PPARα-SIRT1 Complex Mediates Metabolic Adaptation in Response to Starvation in the Heart
- NAD-Dependent Histone Deacetylase, SIRT1, Plays Essential Roles in the Maintenance of Hematopoietic Stem Cells.
- Impaired Nucleocytoplasmic Shuttling of SIRT1 in the Senescent Heart in Response to Ischemic Stress
- SIRT1 promotes N-Myc oncogenesis stabilizing N-Myc protein
- SIRT1 ACTIVATES CELL PROLIFERATION ACTIVITY OF HUMAN INTERVERTEBRAL DISC BOTH IN LOW NUTRITIONAL AND CHEMICAL HYPOXIC CONDITIONS …
- SIRT1 blocks apoptosis in human chondrocytes via activation of the IGF-1 Receptor/Akt pathway
- Uncoupling Insulin: SIRT1 boosts insulin release by blocking mitochondrial protein
- The Role of SIRT1 Activation of AMP-Activated Protein Kinase in the Effect of Polyphenols on Lipid Metabolism in HepG2 Cells Exposed to High Glucose.
- SIRT1 deficiency compromises mouse embryonic stem cell differentiation, and embryonic and adult hematopoiesis in the mouse
- Impaired Nucleocytoplasmic Shuttling and Activity of SIRT1 in Response to Ischemic Stress in the Senescent Heart
- Identification of novel mechanisms regulating the NAD+-dependent deacetylase SIRT1
- The SIRT1 activator resveratrol inhibits the mTOR-p70/S6K pathway
- GENETIC VARIANTS IN THE SIRT1 GENE MAY AFFECT DIABETES RISK IN INTERACTION WITH PRENATAL EXPOSURE TO FAMINE: 7E. 01
- p63 overexpression induces downregulation of SIRT1 and accelerated aging phenotypes in the mouse
- Oral SIRT1 Activators Are Neuroprotective for Retinal Ganglion Cells in Experimental Optic Neuritis
- Increased Nuclear Translocation of SIRT1 and MnSOD Up-regulation in Failing Hearts: A Novel Mechanism of the Cardiomyocyte Death Suppression
- AMPKα2 deletion leads to marked alterations in SIRT1 activity, CPT1 expression and basal FA muscle metabolism in high‐fat‐fed mice
- The protective effect of resveratrol on myocardial ischemia-reperfusion injury by SIRT1-p53 pathway in rats
- SIRT1 Activator 3 Potently Induces Apoptosis in Multiple Myeloma Cell Lines and in Primary Human Multiple Myeloma Cells.
- Construction and identification of eukaryotic plasmid expression vectors encoding the short hairpin RNA targeting human SIRT1
- Resveratrol and Other SIRT1 Activators Exert Similar Neuroprotective Effects in Experimental Optic Neuritis
- The NAD-dependent protein deacetylase SIRT1 regulates POMC transcription and ACTH synthesis
- Sirtuin histone deacetylases SIRT1 and SIRT2 as novel targets for the management of prostate cancer
- Interactions between SIRT1 and AP1 reveal a mechanistic insight into the growth promoting properties of alumina…
- The effect of resveratrol intervention on the expression of SIRT1 in the atrial tissues in pigs with chronic atrial fibrillation induced by right atrial tachypacing
- Effect of High Fat and High Energy Diet on Expression of SIRT1/FOXO1 in White Fat Tissue of Young Rats
- Opposing Effects of Sirtuins on Neuronal Survival: SIRT1-Mediated Neuroprotection Is Independent of Its
- The NAD-dependent protein deacetylase SIRT1 is present in the human anterior pituitary gland where it plays a role in GH transcription
- AMP-Activated Protein Kinase Activity Is Altered by Changes in Redox State in HepG2 Cells by a SIRT1-Dependent Mechanism.
- Identification of cofactor network, including SIRT1 and SRC-3, which converges on energy expenditure through PGC-1α
- SIRT1 Limits Endothelial Notch Signaling During Blood Vessel Growth Through NICD Deacetylation
- Effects of SIRT1 inhibition by lentivirus-mediated shRNA vector on apoptosis of porcine preadipocytes.
- A targeted knockdown of sirtuin histone deacetylase SIRT1 imparts significant growth inhibitory effects in human prostate cancer cells.
- SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity Swami R. Narala, Richard C. Allsopp† …
- SIRT1 activator SRT1720 promotes tumor cell migration and lung metastasis in mouse models of breast cancer
- The role of NAMPT/SIRT1/FOXO3a pathway for the leukemic transformation in severe congenital neutropenia (CN) patients.
- p22phox-Based Nox4 Regulates Cellular Survival by Modulating FOXO3A Activity and SIRT1 Expression
- Expression of senescence-associated miR-34c and SIRT1 in premature senescence of human skin fibroblasts induced by ultraviolet B
- Regulatory Role of Resveratrol on SIRT1-mediated Metabolic Syndrome and Significance of SIRT Family Proteins for Prevention and Treatment of Metabolic …
- Role of the SIRT1 Deacetylase in Survival and Imatinib Resistance of CML CD34+ Progenitors.
- Activation of the Longevity Factor, SIRT1 Deacetylase Blocks the Phenylephrine-induced Cardiomyocyte Hypertrophy
- Effects of SIRT1 Hyper-expression Induced by Calorie Restriction on Life Span of β Cells and Insulin Secretion
- Atorvastatin Affects Expression of SIRT1 via Microrna-34a in Circulating Their Progenitor Cells Get Pirated From be with Coronary Artery Disease
- SIRT1 Mediated Deacetylation of Foxo1 Is Involved in Starvation Induced Autophagy in the Heart
- Signal-Responsive Repression of Notch1 Signaling by the SIRT1 Deacetylase Regulates Sprouting Angiogenesis
- Dual role of SIRT1 as a regulator of retinal development and a therapeutic target in age-related macular degeneration
- SIRT1 signalling promotes lipopolysaccharide-induced TNF-a expression in cardiomyocytes
- Endothelial Biology/Homeostasis: The Roles of AMPK and SIRT1 in eNOS Phosphorylation and Deacetylation
- Erratum to “SIRT1 is involved in energy metabolism: The role of chronic ethanol feeding and resveratrol”[Exp. Mol. Path. 85 (2008) 155–159]
- Fetal Hepatic SIRT1, a Histone H3 Deacetylase, Is Decreased in a Nonhuman Primate Model of Maternal Obesity.
- Treatment with a SIRT1 Activator Resveratrol Prevents Cardiomyopathy in Dystrophin-Deficient Mice
- Cisplatin induces SIRT1 in association with histone deacetylation and increased Werner syndrome protein in the kidney
- Activation of SIRT1, a Longevity Gene, Prevents the Development of Diabetic Vasculopathy by Inhibiting Endothelial Senescence
- Expression and function of SIRT1, Sirt4, and glutamate dehydrogenase 1 within the central nervous system
- Nicotinamide Phosphoribosyltransferase (Nampt) Induces NAD+ / SIRT1 Mediated Deacetylation of p53 in Myeloid Cells.
- Activation of a Protein Deacetylase, SIRT1, by Resveratrol Suppresses Progression of Heart Failure and Improves Survival by Up-Regulation of Mn-SOD
- Melatonin, a novel SIRT1 inhibitor, imparts anti-proliferative effects against PCa in vitro in cell culture and in vivo in transgenic adenocarcinoma of mouse prostate …
- SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kγgamma Activity through Deacetylation of Specific Lysine Residues in Mammals
- Enhanced cell viability and decreased expression of a senescence marker exhibited in SIRT1-induced human skin cells Claude dal Farra, PhD, Vincience, Sophia …
- Nicotinamide Phosphoribosyltransferase (Nampt) Induces NAD+/SIRT1 Mediated Deacetylation of FOXO3a in Myeloid Cells.
- Activation of a Class-III Histone Deacetylase, SIRT1, Prevents the Oxidative-stress Mediated Cell-death by Suppressing the Activity of Poly (ADP) Ribose Polymerase …
- Long-Term Treatment with the SIRT1 Activator Resveratrol Ameliorates Cardiomyopathy in Dystrophin-Deficient Mice
- Control of Notch Signaling by Reversible Acetylation Through the Antagonistic Activities of p300/PCAF and SIRT1 in Endothelial Cells
- Activation of SIRT1 Suppresses Hypertrophic Response of Cardiomyocytes by Inhibition of H3K9 Acetylation via Proteasome-mediated p300 Degradation.
- Modulation of the longevity proteins FOXO3a and SIRT1 by chorionic gonadotropin prevents hepatocellular injury during acute liver inflammation
- Down‐regulation of MnSOD via SIRT1/FoxO3a complex increase oxidative stress with cardiac overexpression of Type 5 Adenylyl Cyclase
- Novel SIRT1 Agonists, SRT501 and SRT2183, Induce Expression of DNA Repair Genes and Apoptosis of Ph− Acute Lymphoblastic Leukemia Cells Alone and in …
- Increased SIRT1 following repetitive hypoxic preconditioning: A mechanism for mediating long-term tolerance (LTT) to focal stroke in adult mouse brain
- Apo-10′-lycopenoic acid increases both mRNA and protein levels of SIRT1 as well as decreasing the fat accumulation in the livers of ob/ob mice
- Hepatitis B virus X (HBX) Protein Inhibits the Expression of SIRT1 Deacetylase, Leading to Up-regulation of Survivin for the Survival of Hepatocellular Carcinoma Cells
- Nicotinamide activates the p53/miR-34a/SIRT1 tumor suppressor network leading to apoptosis of chronic lymphocytic leukemia cells
- Regulation of WRN Function by Acetylation and SIRT1-Mediated Deacetylation in Response to DNA Damage: A Dissertation
- Resveratrol Induces Cell Growth Arrest and Cell Death of Adult T-Cell Leukemia Cells Via Deacetylation of STAT3 by SIRT1
- … protein kinase α1 silencing provides evidence for a Metformin‐induced decrease in FA uptake and oxidation and increase in glucose uptake and SIRT1 activity in L6 …
- Endothelial Cell Polyploidization Induces an Atherogenic Phenotype and is Prevented by Activating the Nampt-SIRT1 Axis
- 441 INTRAUTERINE GROWTH RETARDATION MODULATES SIRT1 DEACETYLASE, FOXO3 TRANSCRIPTION FACTOR, AND SUPEROXIDE DISMUTASE 2 …
- Acetyltransfer in gene regulation: Structural and biochemical studies of human SIRT1 deacetylase, its FoxO1 substrate, and archaeal PAT acetyltransferase
- Nicotinamide Promotes Apoptosis In Chronic Lymphocytic Leukemia through Activation of the p53/Mir-34a/SIRT1 Tumor Suppressor Network
- Cardiac protective effects of resveratrol and SIRT1 in old rat with emphysema induced by cigarette smoke-expose and lipopolysaccharide instillation: attenuation of …
- Abstract# 183: SIRT1 contributes to tumorigenicity and radioresistance in glioblastoma CD133+ cells
- SIRT1 inhibits transforming growth factor β-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation
- SIRT1 represses estrogen-signaling, ligand-independent estrogen receptor alpha-mediated transcription, and cell proliferation in breast cancer cells via …
- Cover Picture: Phloroglucinol Derivatives Guttiferone G, Aristoforin, and Hyperforin: Inhibitors of Human Sirtuins SIRT1 and SIRT2 (Angew. Chem. Int. Ed. 27/2007)
- 875 RESVERATROL, A POLYPHENOLIC SIRT1 ACTIVATOR, IMPROVES ERECTILE FUNCTION IN STREPTOZOTOCIN INDUCED DIABETIC RATS
- TR-FRET Assay for Sirtuin 1 (SIRT1) Inhibitor Screening
- Co-Upregulation of Peroxisome Proliferator-Activated Receptor-Alpha (PPARalpha) and Silent Information Regulator 1 (SIRT1) Negatively Regulates Cardiac Function …
- Sirtuin 1 (SIRT1) regulates the HSF1-dependent pro-survival mechanism in neurons
- Interplay Between Hypoxia-inducible Factor 1 [alpha] and SIRT1 Protein Deacetylase in Hypoxic Cancer Cells
- 57: Histone deacetylase SIRT1 alterations parallel fetal epigenetic and metabolic reprogramming in response to a maternal high fat (MHF) diet
- Abstract# 3569: Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates\# 946;-Catenin signaling and NF\# 954; B-specific transcription activity leading …
- 032 A REDUCTION IN SIRT1 LEVELS IN OA ARTICULAR CARTILAGE IS ASSOCIATED WITH AN INCREASE IN PTP1B, MMP13 AND CHONDROCYTE APOPTOSIS
- Regulation of the transcription factor GATA-3 within T cells-Involvement of SIRT1, a class III histone deacetylase
- Activation of the AKT Pathway Mediates Upregulation of Hif-1α and SIRT1 via Downregulation of miR-199a and is Neutralized by Beta-adrenergic Stimulation
- Abstract LB-427: Differential effects of resveratrol-induced SIRT1 in prostate cancer: A novel therapeutic target
- Influence of AP endonuclease 1 deacetylation by protein deacetylase SIRT1 on DNA base excision repair
- Microrna-195 Promotes Apoptosis in Cardiomyocytes by Down-Regulating SIRT1
- Influence of Ethnicity in Association of UCP2‐866G/A, PGC1α (Gly 482 Ser) and SIRT1‐1400T/C Polymorphisms in North Indian Punjabi Population Groups
- Abstract LB-185: Oxidative damage targets complexes containing DNA methyltransferases, SIRT1 and polycomb members to promoter CpG islands
- SIRT1 and energy metabolism
- The roles of SIRT1 in cancer
- The ways and means that fine tune SIRT1 activity
- MicroRNA regulation of SIRT1
- Negative regulation of inflammation by SIRT1
- SIRT1 in type 2 diabetes: mechanisms and therapeutic potential
- Neuroprotective role of SIRT1 in mammalian models of Huntington’s disease through activation of multiple SIRT1 targets
- Evidence for a common mechanism of SIRT1 regulation by allosteric activators
- Crosstalk between oxidative stress and SIRT1: impact on the aging process
- The role of SIRT1 in ocular aging
- Regulation of FOXOs and p53 by SIRT1 modulators under oxidative stress
- Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders
- SIRT1: new avenues of discovery for disorders of oxidative stress
- SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons
- SIRT1, metabolism and cancer
- Identification of a SIRT1 mutation in a family with type 1 diabetes
- Regulation of SIRT1 by microRNAs
- Targeting cardiovascular disease with novel SIRT1 pathways
- SIRT1 and SIRT2: emerging targets in neurodegeneration
- Janus-faced role of SIRT1 in tumorigenesis
- SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging
- Redox regulation of SIRT1 in inflammation and cellular senescence
- SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
- Stress inducibility of SIRT1 and its role in cytoprotection and cancer
- Regulation of SIRT1 activity by genotoxic stress
- Emerging roles of SIRT1 in cancer drug resistance
- Overexpression of SIRT1 protein in neurons protects against experimental autoimmune encephalomyelitis through activation of multiple SIRT1 targets
- SIRT1 is required for long-term growth of human mesenchymal stem cells
- Towards elucidating the role of SIRT1 in osteoarthritis.
- Roles of SIRT1 in leukemogenesis
- SIRT1: regulator of p53 deacetylation
- The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop
- Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis
- SIRT1 in metabolic syndrome: where to target matters
- SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin
- Brown remodeling of white adipose tissue by SIRT1-dependent deacetylation of Pparγ
- Brain activation of SIRT1: role in neuropathology
- SIRT1 activation by resveratrol is substrate sequence-selective
- Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways
- High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction
- The effects of SIRT1 on Alzheimer’s disease models
- SIRT1 promotes tumorigenesis and resistance to chemotherapy in hepatocellular carcinoma and its expression predicts poor prognosis
- Deacetylation by SIRT1 reprograms inflammation and cancer
- The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing
- Antitumor effect of SIRT1 inhibition in human HCC tumor models in vitro and in vivo
- SIRT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a/PGC-1α complex
- SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells
- SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis
- Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib
- SIRT1 protects against α-synuclein aggregation by activating molecular chaperones
- MicroRNA-34a regulates the longevity-associated protein SIRT1 in coronary artery disease: effect of statins on SIRT1 and microRNA-34a expression
- Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary
- SIRT1 as a therapeutic target in inflammaging of the pulmonary disease
- SIRT1 expression is associated with good prognosis in colorectal cancer
- Metabolic actions of hypothalamic SIRT1
- SIRT1 regulates dendritic development in hippocampal neurons
- SIRT1 mediates hyperbaric oxygen preconditioning-induced ischemic tolerance in rat brain
- SIRT1 negatively regulates the activities, functions, and protein levels of hMOF and TIP60
- Peripheral blood monocyte SIRT1 expression is reduced in patients with coronary artery disease
- Dilated cardiomyopathy and mitochondrial dysfunction in SIRT1-deficient mice: a role for SIRT1-Mef2 in adult heart
- Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1α protein under hypoxic conditions
- Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress
- The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin‐1β in human chondrocytes
- SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice
- SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis
- SIRT1-deficient mice exhibit an altered cartilage phenotype
- SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity
- SIRT1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH
- Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain
- SIRT1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway
- SIRT1 contains N-and C-terminal regions that potentiate deacetylase activity
- Anti-aging molecule, SIRT1: a novel therapeutic target for diabetic nephropathy
- Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex
- Adipose tissue and liver expression of SIRT1, 3, and 6 increase after extensive weight loss in morbid obesity
- Discovery of Thieno[3,2-d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3
- Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights
- SIRT1 modulates MAPK pathways in ischemic–reperfused cardiomyocytes
- SIRT1 is dispensable for function of hematopoietic stem cells in adult mice
- SIRT1 regulation modulates stroke outcome
- Renal tubular SIRT1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes
- The role of SIRT1 in muscle mitochondrial turnover
- Age-associated decrease of SIRT1 expression in rat hippocampus: prevention by late onset caloric restriction
- A SUMOylation-dependent pathway regulates SIRT1 transcription and lung cancer metastasis
- Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence
- SIRT1 catalytic activity is required for male fertility and metabolic homeostasis in mice
- SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency
- SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes
- Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol
- SIRT1: Def-eating senescence?
- SIRT1 promotes axonogenesis by deacetylation of Akt and inactivation of GSK3
- Regulation of SIRT1 by oxidative stress-responsive miRNAs and a systematic approach to identify its role in the endothelium
- SIRT1-an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis
- SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas
- Effects of resveratrol and SIRT1 on PGC-1α activity and mitochondrial biogenesis: a reevaluation
- Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SIRT1 mice
- USP22 antagonizes p53 transcriptional activation by deubiquitinating SIRT1 to suppress cell apoptosis and is required for mouse embryonic development
- New synthetic approach to paullones and characterization of their SIRT1 inhibitory activity
- A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration
- A maternal high‐fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates
- SIRT1 is a highly networked protein that mediates the adaptation to chronic physiological stress
- SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury
- SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression
- Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1
- SIRT1 signaling as potential modulator of skeletal muscle diseases
- Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity
- Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo
- SIRT1 Polymorphism, Long-Term Survival and Glucose Tolerance in the General Population
- SIRT1 enhances matrix metalloproteinase‐2 expression and tumor cell invasion in prostate cancer cells
- A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers
- SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: implications for vascular aging
- High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma
- SIRT1 promotes proliferation and inhibits apoptosis of human malignant glioma cell lines
- SIRT1 is a direct coactivator of thyroid hormone receptor β1 with gene-specific actions
- Resveratrol inhibits ionising irradiation-induced inflammation in MSCs by activating SIRT1 and limiting NLRP-3 inflammasome activation
- SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism
- AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells
- SIRT1 is downregulated in gastric cancer and leads to G1-phase arrest via NF-κB/Cyclin D1 signaling
- Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer
- SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells
- SIRT1 inactivation induces inflammation through the dysregulation of autophagy in human THP-1 cells
- Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria
- SIRT1 protein, by blocking the activities of transcription factors FoxO1 and FoxO3, inhibits muscle atrophy and promotes muscle growth
- Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression
- SIRT1 expression is associated with the chemotherapy response and prognosis of patients with advanced NSCLC
- The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury
- A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53
- Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinoma
- SIRT1, a histone deacetylase, regulates prion protein-induced neuronal cell death
- Essential role of SIRT1 signaling in the nucleus accumbens in cocaine and morphine action
- SIRT1 regulates the neurogenic potential of neural precursors in the adult subventricular zone and hippocampus
- Neuronal SIRT1 deficiency increases insulin sensitivity in both brain and peripheral tissues
- Genetic analysis of the SIRT1 gene promoter in myocardial infarction
- miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease
- Genetic analysis of SIRT1 gene promoter in sporadic Parkinson’s disease
- SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer’s Disease
- Expression of SIRT1 and DBC1 is associated with poor prognosis of soft tissue sarcomas
- SIRT1 regulates endothelial Notch signaling in lung cancer
- SIRT1 negatively regulates amyloid-beta-induced inflammation via the NF-κB pathway
- Autophagy induced by the class III histone deacetylase SIRT1 prevents prion peptide neurotoxicity
- Resveratrol inhibits β-amyloid-induced neuronal apoptosis through regulation of SIRT1-ROCK1 signaling pathway
- Extranuclear localization of SIRT1 and PGC-1α: an insight into possible roles in diseases associated with mitochondrial dysfunction
- Resveratrol Inhibits CD4+ T Cell Activation by Enhancing the Expression and Activity of SIRT1
- PIASy mediates hypoxia-induced SIRT1 transcriptional repression and epithelial-to-mesenchymal transition in ovarian cancer cells
- Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK–SIRT1–PGC1α axis in db/db mice
- Nicotinamide-induced mitophagy: event mediated by high NAD+/NADH ratio and SIRT1 protein activation
- High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T‐cell leukemia cells
- Resveratrol protects cardiomyocytes from oxidative stress through SIRT1 and mitochondrial biogenesis signaling pathways
- Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase
- SIRT1 inhibition by melatonin exerts antitumor activity in human osteosarcoma cells
- Resveratrol reduces acute lung injury in a LPS‑induced sepsis mouse model via activation of SIRT1
- Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice
- SIRT1 and CLOCK 3111T> C combined genotype is associated with evening preference and weight loss resistance in a behavioral therapy treatment for obesity
- SIRT1 regulates cd40 expression induced by tnf-α via nf-ĸb pathway in endothelial cells
- Expression of SIRT1 and DBC1 in Gastric Adenocarcinoma
- Activation of SIRT1 protects pancreatic β-cells against palmitate-induced dysfunction
- Modulatory effect of resveratrol on SIRT1, SIRT3, SIRT4,PGC1α and NAMPT gene expression profiles in wild-type adult zebrafish liver
- Nicotinamide, a SIRT1 inhibitor, inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and …
- SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice
- The loss of SIRT1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing
- Resveratrol‐mediated apoptosis of hodgkin lymphoma cells involves SIRT1 inhibition and FOXO3a hyperacetylation
- Cross-talk between SIRT1 and p66Shc in vascular diseases
- Accelerated recovery of renal mitochondrial and tubule homeostasis with SIRT1/PGC-1α activation following ischemia–reperfusion injury
- SIRT1 resists advanced glycation end products-induced expressions of fibronectin and TGF-β1 by activating the Nrf2/ARE pathway in glomerular mesangial cells
- SIRT1 promotes RGC survival and delays loss of function following optic nerve crush
- SIRT1 attenuates palmitate-induced endoplasmic reticulum stress and insulin resistance in HepG2 cells via induction of oxygen-regulated protein 150
- Interferon gamma (IFN-γ) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcription
- SIRT1 expression is associated with good prognosis for head and neck squamous cell carcinoma patients
- Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer
- Unraveling the complexities of SIRT1-mediated mitochondrial regulation in skeletal muscle
- Angiogenic Deficiency and Adipose Tissue Dysfunction Are Associated with Macrophage Malfunction in SIRT1−/− Mice
- NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells
- Resveratrol protects against hyperglycemia-induced oxidative damage to mitochondria by activating SIRT1 in rat mesangial cells
- Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway
- SIRT1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of Akt pathway
- Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation
- Resveratrol inhibits the growth of gastric cancer by inducing G1 phase arrest and senescence in a SIRT1-dependent manner
- Resveratrol activates SIRT1 in a Lamin A-dependent manner
- SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human …
- SIRT1 gene polymorphisms are associated with growth traits in Nanyang cattle
- Expression of SIRT1 is associated with lymph node metastasis and poor prognosis in both operable triple-negative and non-triple-negative breast cancer
- Identification of a small molecule activator of SIRT1 gene expression
- SIRT1, p66Shc, and Set7/9 in vascular hyperglycemic memory: bringing all the strands together
- Systemic SIRT1 insufficiency results in disruption of energy homeostasis and steroid hormone metabolism upon high‐fat‐diet feeding
- BCL6 controls neurogenesis through SIRT1-dependent epigenetic repression of selective Notch targets
- SIRT1 silencing confers neuroprotection through IGF‐1 pathway activation
- SIRT1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenanceSIRT1 in adult stem cell homeostasis
- Variants in the SIRT1 gene may affect diabetes risk in interaction with prenatal exposure to famine
- Resveratrol facilitates pain attenuation in a rat model of neuropathic pain through the activation of spinal SIRT1
- Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway
- Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms
- SIRT1 prevents replicative senescence of normal human umbilical cord fibroblast through potentiating the transcription of human telomerase reverse transcriptase …
- Hydrogen sulfide prevents H2O2-induced senescence in human umbilical vein endothelial cells through SIRT1 activation
- PPARα and SIRT1 mediate erythropoietin action in increasing metabolic activity and browning of white adipocytes to protect against obesity and metabolic disorders
- Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative breast cancer cells
- Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis
- SIRT1 inhibits the transcription factor CREB to regulate pituitary growth hormone synthesis
- Impaired cardiac SIRT1 activity by carbonyl stress contributes to aging-related ischemic intolerance
- SIRT1 suppresses breast cancer growth through downregulation of the Bcl-2 protein
- SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling
- Discovery of a potent small molecule SIRT1/2 inhibitor with anticancer effects
- Association between low SIRT1 expression in visceral and subcutaneous adipose tissues and metabolic abnormalities in women with obesity and type 2 diabetes
- Effect of dietary macronutrient composition on AMPK and SIRT1 expression and activity in human skeletal muscle
- The full capacity of AICAR to reduce obesity-induced inflammation and insulin resistance requires myeloid SIRT1
- Hepatitis B virus X (HBX) protein upregulates β-catenin in a human hepatic cell line by sequestering SIRT1 deacetylase
- Resveratrol protects HUVECs from oxidized-LDL induced oxidative damage by autophagy upregulation via the AMPK/SIRT1 pathway
- Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate
- Testosterone deficiency accelerates neuronal and vascular aging of SAMP8 mice: protective role of eNOS and SIRT1
- CBX8 suppresses Sirtinol-induced premature senescence in human breast cancer cells via cooperation with SIRT1
- Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear …
- SIRT1 overexpression decreases cisplatin-induced acetylation of NF-κB p65 subunit and cytotoxicity in renal proximal tubule cells
- Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis
- A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex
- SIRT1 positively regulates breast cancer associated human aromatase (CYP19A1) expression
- Resveratrol improves cardiac contractility following trauma-hemorrhage by modulating SIRT1
- Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats
- Decreased vitamin B12 availability induces ER stress through impaired SIRT1-deacetylation of HSF1
- SIRT1 regulates adaptive response of the growth hormone–insulin-like growth factor-I axis under fasting conditions in liver
- Regulation of SIRT1-nucleomethylin binding by rRNA coordinates ribosome biogenesis with nutrient availability
- SIRT1 is highly expressed in brain metastasis tissues of non-small cell lung cancer (NSCLC) and in positive regulation of NSCLC cell migration
- mIGF‐1/JNK1/SIRT1 signaling confers protection against oxidative stress in the heart
- Regulation of SIRT1 determines initial step of endometrial receptivity by controlling E-cadherin expression
- Endothelium-specific SIRT1 overexpression inhibits hyperglycemia-induced upregulation of vascular cell senescence
- DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage
- Resveratrol Improves Cardiomyopathy in Dystrophin-deficient Mice through SIRT1 Protein-mediated Modulation of p300 Protein*[S]
- TNF-α inhibits PPARβ/δ activity and SIRT1 expression through NF-κB in human adipocytes
- A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells
- SIRT1 is required for the effects of rapamycin on high glucose-inducing mesangial cells senescence
- The role of SIRT1 on angiogenic and odontogenic potential in human dental pulp cells
- SIRT1 regulates TNF-α-induced expression of CD40 in 3T3-L1 adipocytes via NF-κB pathway
- Transcription factor NFκB regulates the expression of the histone deacetylase SIRT1
- The Interactive Effect of SIRT1 Promoter Region Polymorphism on Type 2 Diabetes Susceptibility in the North Indian Population
- Inhibition of cortactin and SIRT1 expression attenuates migration and invasion of prostate cancer DU145 cells
- Terpenylated Coumarins As SIRT1 Activators Isolated from Ailanthus altissima
- Resveratrol induces SIRT1-dependent apoptosis in 3T3-L1 preadipocytes by activating AMPK and suppressing AKT activity and survivin expression
- The PPARδ-mediated inhibition of angiotensin II-induced premature senescence in human endothelial cells is SIRT1-dependent
- Fortifying the link between SIRT1, resveratrol, and mitochondrial function
- SIRT1 prevents atherosclerosis via liver‑X‑receptor and NF‑κB signaling in a U937 cell model
- Hepatic deletion of SIRT1 decreases hepatocyte nuclear factor 1α/farnesoid X receptor signaling and induces formation of cholesterol gallstones in mice
- Skeletal muscle-specific overexpression of SIRT1 does not enhance whole-body energy expenditure or insulin sensitivity in young mice
- Association of SIRT1 expression with shear stress induced endothelial progenitor cell differentiation
- The involvement of SIRT1 and transcription factor NF-κB (p50/p65) in regulation of porcine ovarian cell function
- Enterocyte-Specific Inactivation of SIRT1 Reduces Tumor Load in the APC+/min Mouse Model
- The SIRT1 modulators AROS and DBC1 regulate HSF1 activity and the heat shock response
- Spiro heterocycles as potential inhibitors of SIRT1: Pd/C-mediated synthesis of novel N-indolylmethyl spiroindoline-3, 2′-quinazolines
- Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity
- SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of β …
- SIRT1 protects against thrombomodulin down-regulation and lung coagulation after particulate matter exposure
- A deacetylase-deficient SIRT1 variant opposes full-length SIRT1 in regulating tumor suppressor p53 and governs expression of cancer-related genes
- Visfatin is expressed in human granulosa cells: regulation by metformin through AMPK/SIRT1 pathways and its role in steroidogenesis
- SIRT1 inhibits TNF-α-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1
- … protein kinase α (AMPKα) by doxorubicin accentuates genotoxic stress and cell death in mouse embryonic fibroblasts and cardiomyocytes: role of p53 and SIRT1
- Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in …
- Hepatitis C virus core protein induces hepatic metabolism disorders through down-regulation of the SIRT1–AMPK signaling pathway
- SIRT1 as a novel potential treatment target for vascular aging and age-related vascular diseases
- 17‐β Oestradiol prevents cardiovascular dysfunction in post‐menopausal metabolic syndrome by affecting SIRT1/AMPK/H3 acetylation
- SIRT1 overexpression protects murine osteoblasts against TNF-α-induced injury in vitro by suppressing the NF-κB signaling pathway
- Nicotinamide‑mediated inhibition of SIRT1 deacetylase is associated with the viability of cancer cells exposed to antitumor agents and apoptosis
- SIRT1 attenuates diabetic albuminuria
- Telmisartan ameliorates insulin sensitivity by activating the AMPK/SIRT1 pathway in skeletal muscle of obese db/db mice
- … in overweight males ameliorates obesity-related metabolic alterations and cellular adaptations through anti-aging effects, possibly including AMPK and SIRT1 …
- Overexpression of SIRT1 Promotes High Glucose–Attenuated Corneal Epithelial Wound Healing via p53 Regulation of the IGFBP3/IGF-1R/AKT Pathway
- Pharmacological activation of SIRT1 ameliorates polyglutamine-induced toxicity through the regulation of autophagy
- Suppression of ERR targets by a PPARα/SIRT1 complex in the failing heart
- SIRT1 represses estrogen-signaling, ligand-independent ERα-mediated transcription, and cell proliferation in estrogen-responsive breast cells
- SIRT1 regulates radiosensitivity of hepatoma cells differently under normoxic and hypoxic conditions
- Omega-3 polyunsaturated fatty acids antagonize macrophage inflammation via activation of AMPK/SIRT1 pathway
- SIRT1-mediated FoxO1 deacetylation is essential for multidrug resistance-associated protein 2 expression in tamoxifen-resistant breast cancer cells
- Isoflavones derived from soy beans prevent MuRF1-mediated muscle atrophy in C2C12 myotubes through SIRT1 activation
- SIRT1 regulates the human alveolar epithelial A549 cell apoptosis induced by Pseudomonas aeruginosa lipopolysaccharide
- Autophagy counteracts apoptosis in human multiple myeloma cells exposed to oridonin in vitro via regulating intracellular ROS and SIRT1
- The NAD+-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status
- Effects of SIRT1 on DNA methylation and expression of genes affected by dietary restriction
- SIRT1 inhibits akt2-mediated porcine adipogenesis potentially by direct protein-protein interaction
- The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD+) and an Indole (EX527 Analogue) Reveals a Novel …
- When is SIRT1 activity bad for dying neurons?
- Novel acridinedione derivatives: design, synthesis, SIRT1 enzyme and tumor cell growth inhibition studies
- Aerobic endurance capacity affects spatial memory and SIRT1 is a potent modulator of 8-oxoguanine repair
- IL-15 overexpression promotes endurance, oxidative energy metabolism, and muscle PPARδ, SIRT1, PGC-1α, and PGC-1β expression in male mice
- Identification and characterization of novel indole based small molecules as anticancer agents through SIRT1 inhibition
- Angiotensin-converting-enzyme inhibition counteracts angiotensin II-mediated endothelial cell dysfunction by modulating the p38/SIRT1 axis
- Enantioselective Synthesis of Cyclohepta[b]indoles: Gram-Scale Synthesis of (S)-SIRT1-Inhibitor IV
- Resveratrol suppresses the STAT3 signaling pathway and inhibits proliferation of high glucose-exposed HepG2 cells partly through SIRT1
- Inhibition of SIRT1 by HIV-1 viral protein Tat results in activation of p53 pathway
- Rejuvenating SIRT1 activators
- Visceral adiposity is associated with SIRT1 expression in peripheral blood mononuclear cells: a pilot study
- Histone deacetylase SIRT1 modulates and deacetylates DNA base excision repair enzyme thymine DNA glycosylase
- Metabolic energy sensors (AMPK and SIRT1), protein carbonylation and cardiac failure as biomarkers of thermal stress in an intertidal limpet: linking energetic …
- The effects of caloric restriction and a high-fat diet on ovarian lifespan and the expression of SIRT1 and SIRT6 proteins in rats
- c-MYC and SIRT1 locked in a vicious cycle
- SIRT1 interacts with metabolic transcriptional factors in the pancreas of insulin-resistant and calorie-restricted rats
- The role of SIRT1/AKT/ERK pathway in ultraviolet B induced damage on human retinal pigment epithelial cells
- Hepatic menin recruits SIRT1 to control liver steatosis through histone deacetylation
- SIRT1 deacetylates FOXA2 and is critical for Pdx1 transcription and β-cell formation
- SIRT1 deacetylates RFX5 and antagonizes repression of collagen type I (COL1A2) transcription in smooth muscle cells
- SIRT1 pathway dysregulation in the smoke-exposed airway epithelium and lung tumor tissue
- Involvement of SIRT1 in hypoxic down-regulation of c-Myc and β-catenin and hypoxic preconditioning effect of polyphenols
- WISP1 neuroprotection requires FoxO3a post-translational modulation with autoregulatory control of SIRT1
- The Tellurium compound, AS101, increases SIRT1 level and activity and prevents type 2 diabetes
- Carvacrol protects against hepatic steatosis in mice fed a high-fat diet by enhancing SIRT1-AMPK signaling
- SIRT1 Regulation—It Ain’t All NAD
- β-Cryptoxanthin restores nicotine-reduced lung SIRT1 to normal levels and inhibits nicotine-promoted lung tumorigenesis and emphysema in A/J mice
- Regulation of Glycolytic Enzyme Phosphoglycerate Mutase-1 by SIRT1 Protein-mediated Deacetylation♦
- Activation of type 2 cannabinoid receptors (CB2R) promotes fatty acid oxidation through the SIRT1/PGC-1α pathway
- Salvianolic acid A preconditioning confers protection against concanavalin A-induced liver injury through SIRT1-mediated repression of p66shc in mice
- Expression of SIRT1 and DBC1 in developing and adult retinas
- Epsilon PKC increases brain mitochondrial SIRT1 protein levels via heat shock protein 90 following ischemic preconditioning in rats
- Ethylenediamine diacetate (EDDA) mediated synthesis of aurones under ultrasound: Their evaluation as inhibitors of SIRT1
- Acetylation status of P53 and the expression of DBC1, SIRT1, and androgen receptor are associated with survival in clear cell renal cell carcinoma patients
- Current advances in the synthesis and antitumoral activity of SIRT1-2 inhibitors by modulation of p53 and pro-apoptotic proteins
- Nicotinamide prohibits proliferation and enhances chemosensitivity of pancreatic cancer cells through deregulating SIRT1 and Ras/Akt pathways
- SIRT1 activation protects against autoimmune T cell-driven retinal disease in mice via inhibition of IL-2/Stat5 signaling
- Expression of SIRT1 in choroidal neovascular membranes
- Expression patterns and potential roles of SIRT1 in human medulloblastoma cells in vivo and in vitro
- Cellular NAD depletion and decline of SIRT1 activity play critical roles in PARP-1-mediated acute epileptic neuronal death in vitro
- Transcriptional and translational regulation of C/EBPβ-HDAC1 protein complexes controls different levels of p53, SIRT1, and PGC1α proteins at the early and late …
- Activation of SIRT1 by resveratrol requires lamin A
- Docosahexaenoic acid improves vascular function via up-regulation of SIRT1 expression in endothelial cells
- Association between SIRT1 gene polymorphisms and longevity of populations from Yongfu region of Guangxi
- MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cells
- SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-κ B/STAT3 complex to its promoter in …
- PARP1 inhibition affects pleural mesothelioma cell viability and uncouples AKT/mTOR axis via SIRT1
- Does SIRT1 determine exercise-induced skeletal muscle mitochondrial biogenesis: differences between in vitro and in vivo experiments?
- Anti-correlation between longevity gene SIRT1 and Notch signaling in ascending aorta biopsies from patients with bicuspid aortic valve disease
- MiR-199a-5p promotes migration and tube formation of human cytomegalovirus-infected endothelial cells through downregulation of SIRT1 and eNOS
- Exendin-4 improves steatohepatitis by increasing SIRT1 expression in high-fat diet-induced obese C57BL/6J mice
- DBC1 does not function as a negative regulator of SIRT1 in liver cancer
- SIRT1–Claudin-1 crosstalk regulates renal function
- Inhibition of SIRT1 combined with gemcitabine therapy for pancreatic carcinoma
- PPARα agonist fenofibrate attenuates TNF-α-induced CD40 expression in 3T3-L1 adipocytes via the SIRT1-dependent signaling pathway
- SIRT1 interacts with and protects glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from nuclear translocation: implications for cell survival after irradiation
- Molecular architecture of the human protein deacetylase SIRT1 and its regulation by AROS and resveratrol
- Region-specific changes in the immunoreactivity of SIRT1 expression in the central nervous system of SOD1G93A transgenic mice as an in vivo model of amyotrophic …
- Epigallocatechin-3-gallate suppresses 1-methyl-4-phenyl-pyridine-induced oxidative stress in PC12 cells via the SIRT1/PGC-1α signaling pathway
- SIRT1 inhibits the mouse intestinal motility and epithelial proliferation
- … and anti‐inflammatory effects of melatonin in hydrogen peroxide‐stimulated CHON‐001 human chondrocyte cell line and rabbit model of osteoarthritis via the SIRT1 …
- Amurensin G, a novel SIRT1 inhibitor, sensitizes TRAIL-resistant human leukemic K562 cells to TRAIL-induced apoptosis
- Vitamin D protects human endothelial cells from H 2 O 2 oxidant injury through the Mek/Erk-SIRT1 axis activation
- The identification of the SIRT1 activator SRT2104 as a clinical candidate
- The brain: A new organ for the metabolic actions of SIRT1
- SIRT1 suppresses PMA and ionomycin-induced ICAM-1 expression in endothelial cells
- SIRT1 and the clock gene machinery in colorectal cancer
- Hypermethylation of HIC1 promoter and aberrant expression of HIC1/SIRT1 might contribute to the carcinogenesis of pancreatic cancer
- Molecular dissection of the interaction between HIC1 and SIRT1
- Human SIRT1 regulates DNA binding and stability of the Mcm10 DNA replication factor via deacetylation
- Aggravation of nonalcoholic steatohepatitis by moderate alcohol consumption is associated with decreased SIRT1 activity in rats
- … Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFα)-induced apoptosis through SIRT1 …
- Poor glycaemic control in type 2 diabetes patients reduces endothelial progenitor cell number by influencing SIRT1 signalling via platelet-activating factor …
- Expression of SIRT1 in ocular surface squamous neoplasia
- SIRT1 inhibits resistin expression in aortic stenosis
- Association of Sirtuin 1 (SIRT1) Gene SNPs and Transcript Expression Levels With Severe Obesity
- Skeletal muscle SIRT1 and the genetics of metabolic health: therapeutic activation by pharmaceuticals and exercise
- Modeling miRNA regulation in cancer signaling systems: miR-34a regulation of the p53/SIRT1 signaling module
- Bitter melon extract attenuating hepatic steatosis may be mediated by FGF21 and AMPK/SIRT1 signaling in mice
- Insulin signal meets SIRT1 at Akt
- SIRT1 confers hypoxia-induced radioresistance via the modulation of c-Myc stabilization on hepatoma cells
- hMOF acetylation of DBC1/CCAR2 prevents binding and inhibition of SIRT1
- #VALUE!
- Regulation of SIRT1 in vascular smooth muscle cells from streptozotocin-diabetic rats
- Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity
- SIRT1, p53, and p38MAPK Are Crucial Regulators of Detrimental Phenotypes of Embryonic Stem Cells with Max Expression Ablation
- Androgen depletion in humans leads to cavernous tissue reorganization and upregulation of SIRT1–eNOS axis
- The time-dependent autophagy protects against apoptosis with possible involvement of SIRT1 protein in multiple myeloma under nutrient depletion
- Activation of AMPK–SIRT1 pathway by telmisartan in white adipose tissue: A possible link to anti-metabolic effects
- SIRT1 attenuates camptothecin-induced apoptosis through caspase-3 pathway in porcine preadipocytes
- Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism
- SIRT1 mediates the protective function of Nkx2. 5 during stress in cardiomyocytes
- Metabolic stress modulates Alzheimer’s β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons
- MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration
- Pentamethylquercetin reduces fat deposition via SIRT1-mediated pathways in male obese mice induced by a high fat diet
- The hydrolase DDAH2 enhances pancreatic insulin secretion by transcriptional regulation of secretagogin through a SIRT1‐dependent mechanism in mice
- Late-onset running biphasically improves redox balance, energy-and methylglyoxal-related status, as well as SIRT1 expression in mouse hippocampus
- The expression of SIRT1 and DBC1 in laryngeal and hypopharyngeal carcinomas
- An autoregulatory loop reverts the mechanosensitive SIRT1 induction by EGR1 in skeletal muscle cells
- SIRT1 attenuates neointima formation by inhibiting HIF-1α expression in neointimal lesion of a murine wire-injured femoral artery
- MiR-34a is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation through the SIRT1/NFκB pathway
- Three single nucleotide variants of the SIRT1 gene are associated with overweight in a Chinese population: a case control study
- SIRT1 deacetylates SATB1 to facilitate MAR HS2 -MAR ε interaction and promote ε-globin expression
- Diet-induced obesity promotes murine gastric cancer growth through a nampt/SIRT1/c-myc positive feedback loop
- MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1
- Resveratrol prevents dexamethasone-induced expression of the muscle atrophy-related ubiquitin ligases atrogin-1 and MuRF1 in cultured myotubes through a SIRT1 …
- SIRT1 exerts anti-inflammatory effects and promotes steroidogenesis in Leydig cells
- The tumor suppressor protein menin inhibits NF-κB-mediated transactivation through recruitment of SIRT1 in hepatocellular carcinoma
- SIRT1 suppresses RNA synthesis after UV irradiation in combined xeroderma pigmentosum group D/Cockayne syndrome (XP-D/CS) cells
- SIRT1 sensitizes hepatocellular carcinoma cells expressing hepatitis B virus X protein to oxidative stress-induced apoptosis
- The mitochondrial SIRT1–PGC-1α axis in podocyte injury
- SIRT1, heme oxygenase-1 and NO-mediated vasodilation in a human model of endogenous angiotensin II type 1 receptor antagonism: implications for …
- Chitooligosaccharide induces mitochondrial biogenesis and increases exercise endurance through the activation of SIRT1 and AMPK in rats
- SIRT1 and Connexin40 Mediate the normal shear stress-induced inhibition of the proliferation of endothelial cells co-cultured with vascular smooth muscle cells
- Growth inhibition and apoptosis-inducing effects of cudraflavone B in human oral cancer cells via MAPK, NF-κB, and SIRT1 signaling pathway
- Synergistic actions of insulin-sensitive and SIRT1-mediated pathways in the differentiation of mouse embryonic stem cells to osteoblast
- α-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase
- Investigation of silent information regulator 1 (SIRT1) agonists from Traditional Chinese Medicine
- Involvement of SIRT1–AMPK signaling in the protective action of indole-3-carbinol against hepatic steatosis in mice fed a high-fat diet
- MicroRNA-217 promotes ethanol-induced fat accumulation in hepatocytes by down-regulating SIRT1
- Genetic analysis of the SIRT1 gene promoter in ventricular septal defects
- Upregulation of SIRT1 by 17β-estradiol depends on ubiquitin-proteasome degradation of PPAR-γ mediated by NEDD4-1
- SIRT1 activators: the evidence STACks up
- Hypoxanthine-xanthine oxidase down-regulates GLUT1 transcription via SIRT1 resulting in decreased glucose uptake in human placenta
- miR‐520c and miR‐373 upregulate MMP9 expression by targeting mTOR and SIRT1, and activate the Ras/Raf/MEK/Erk signaling pathway and NF‐κB factor in …
- Omentin-1, a new adipokine, promotes apoptosis through regulating SIRT1-dependent p53 deacetylation in hepatocellular carcinoma cells
- SIRT1 expression and activity are up-regulated in the brain tissue of epileptic patients and rat models
- The combined effects of genetic variation in the SIRT1 gene and dietary intake of n-3 and n-6 polyunsaturated fatty acids on serum LDL-C and HDL-C levels …
- Active regulator of SIRT1 is required for ribosome biogenesis and function
- Nurr1 represses tyrosine hydroxylase expression via SIRT1 in human neural stem cells
- … -associated TDP-43 interacts with fragile X mental retardation protein (FMRP)/Staufen (STAU1) and regulates SIRT1 expression in neuronal cells
- Resistin impairs SIRT1 function and induces senescence-associated phenotype in hepatocytes
- Sirt7 promotes adipogenesis by binding to and inhibiting SIRT1
- Insulin induces neurite outgrowth via SIRT1 in SH-SY5Y cells
- Monacolin K affects lipid metabolism through SIRT1/AMPK pathway in HepG2 cells
- Angiogenic Dysfunction in Bone Marrow‐Derived Early Outgrowth Cells from Diabetic Animals Is Attenuated by SIRT1 Activation
- Saponins from Platycodon grandiflorum inhibit hepatic lipogenesis through induction of SIRT1 and activation of AMP-activated protein kinase in high-glucose-induced …
- SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer
- Activating transcription factor 4 confers a multidrug resistance phenotype to gastric cancer cells through transactivation of SIRT1 expression
- MiR-217 is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation by down-regulation of SIRT1
- Search for a novel SIRT1 activator: Structural modification of SRT1720 and biological evaluation
- Porphyromonas gingivalis lipopolysaccharide regulates interleukin (IL)-17 and IL-23 expression via SIRT1 modulation in human periodontal ligament cells
- Identification of benzofuran-3-yl (phenyl) methanones as novel SIRT1 inhibitors: binding mode, inhibitory mechanism and biological action
- Bisdemethoxycurcumin increases SIRT1 to antagonize t-BHP-induced premature senescence in WI38 fibroblast cells
- Clinicopathological significance of SIRT1 and p300/CBP expression in gastroesophageal junction (GEJ) cancer and the correlation with E-cadherin and MLH1
- Genetic variation in SIRT1 affects susceptibility of lung squamous cell carcinomas in former uranium miners from the Colorado plateau
- Effect of breed on the expression of Sirtuins (SIRT1-7) and antioxidant capacity in porcine brain
- Ginkgolide B reduces LOX-1 expression by inhibiting Akt phosphorylation and increasing SIRT1 expression in oxidized LDL-stimulated human umbilical vein …
- Lentivirus-mediated SIRT1 shRNA and resveratrol independently induce porcine preadipocyte apoptosis by canonical apoptotic pathway
- Potential neuroprotective effects of SIRT1 induced by glucose deprivation in PC12 cells
- Effect of metformin on the expression of SIRT1 and UCP2 in rat liver of type 2 diabetes mellitus and nonalcoholic fatty liver
- Functional Complementation of sir2Δ Yeast Mutation by the Human Orthologous Gene SIRT1
- Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1
- Fragmentation studies of SIRT1‐activating drugs and their detection in human plasma for doping control purposes
- Expression of SIRT1 in right auricle tissues and the relationship with oxidative stress in patients with atrial fibrillation
- Ku70 acetylation and modulation of c-Myc/ATF4/CHOP signaling axis by SIRT1 inhibition lead to sensitization of HepG2 cells to TRAIL through induction of DR5 and …
- Inverse Regulation of the Cytosolic Ca2+ Buffer Parvalbumin and Mitochondrial Volume in Muscle Cells via SIRT1/PGC-1α Axis
- SIRT1 suppresses cellular accumulation of β-TrCP E3 ligase via protein degradation
- Novel SIRT1 mutation linked to autoimmune diabetes in humans
- Upregulation of SIRT1 in carbon-tetrachloride–induced acute liver injury
- Hypothalamic SIRT1 and regulation of food intake
- Cardioprotective mIGF-1/SIRT1 signaling induces hypertension, leukocytosis and fear response in mice
- Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene
- MicroRNA-217 promotes angiogenesis of human cytomegalovirus-infected endothelial cells through downregulation of SIRT1 and FOXO3A
- Sirtuin 1 (SIRT1) and steroid hormone receptor activity in cancer
- Methods to investigate the role of SIRT1 in endothelial senescence
- Electroconvulsive shock increases SIRT1 immunoreactivity in the mouse hippocampus and hypothalamus
- SIRT1 is a useful biomarker for high-grade dysplasia and carcinoma in Barrett’s esophagus
- Resveratrol-poor red wines modulate SIRT1 in human renal cells
- SRT1720, a SIRT1 activator, aggravates bleomycin-induced lung injury in mice
- Resveratrol targeting of carcinogen-induced brain endothelial cell inflammation biomarkers MMP-9 and COX-2 is SIRT1-independent
- Effects of gambogic acid on the activation of caspase-3 and downregulation of SIRT1 in RPMI-8226 multiple myeloma cells via the accumulation of ROS
- SILAC-based quantification of SIRT1-responsive lysine acetylome
- MicroRNAs in the growth plate are responsive to nutritional cues: association between miR-140 and SIRT1
- Diethyl phthalate enhances expression of SIRT1 and DNMT3a during apoptosis in PC12 cells
- Dissecting the Roles of the N‐and C‐Flanking Residues of Acetyllysine Substrates for SIRT1 Activity
- RETRACTED ARTICLE: MicroRNA-126 inhibits osteosarcoma cells proliferation by targeting SIRT1
- Accelerating cancer evolution: a dark side of SIRT1 in genome maintenance
- Commentaries on Viewpoint: Does SIRT1 determine exercise-induced skeletal muscle mitochondrial biogenesis: differences between in vitro and in vivo experiments …
- MicroRNA-142 reduces monoamine oxidase A expression and activity in neuronal cells by downregulating SIRT1
- Nephroprotective action of sirtuin 1 (SIRT1)
- Indole-3-carbinol directly targets SIRT1 to inhibit adipocyte differentiation
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- Measles virus nucleocapsid protein, a key contributor to Paget’s disease, increases IL-6 expression via down-regulation of FoxO3/SIRT1 signaling
- Mechanism of temozolomide-induced anti-tumor effects on glioblastoma cells in vitro is via ROS-dependent SIRT1 signaling pathway
- GATA-binding protein 4 (GATA-4) and T-cell acute leukemia 1 (TAL1) regulate myogenic differentiation and erythropoietin response via cross-talk with Sirtuin1 (SIRT1)
- Mass spectrometric studies on the in vitro generated metabolites of SIRT1 activating drugs for doping control purposes
- Relative quantitative comparison between lipotoxicity and glucotoxicity affecting the PARP-NAD-SIRT1 pathway in hepatocytes
- Metformin, metabolic stress, and mitochondria. Focus on “A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein …
- Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation
- Deacetylase SIRT1 and vascular endothelial function
- PARP-2 knockdown protects cardiomyocytes from hypertrophy via activation of SIRT1
- Involvement of SIRT1 in Zn2+, streptozotocin, non-obese diabetic, and cytokine-mediated toxicities of β-cells
- Cloning expression and purification of human truncated SIRT1
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- SIRT1 inhibits p53 but not NF-κB transcriptional activity during differentiation of mouse embryonic stem cells into embryoid bodies
- Yet another role for SIRT1: reduction of α-synuclein aggregation in stressed neurons
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- Last Word on Viewpoint: Does SIRT1 determine exercise-induced skeletal muscle mitochondrial biogenesis: differences between in vitro and in vivo experiments?
- SIRT1 and anxiety
- A multicancer-like syndrome in a dog characterized by p53 and cell cycle-checkpoint kinase 2 (CHK2) mutations and sirtuin gene (SIRT1) down-regulation
- Resveratrol stimulates extracellular matrix synthesis in degenerative nucleus pulposus cells via upregulation of SIRT1
- SIRT1 suppresses activating transcription factor 4 (ATF4) expression in response to proteasome inhibition
- Incretin-stimulated interaction between β-cell Kv1. 5 and Kvβ2 channel proteins involves acetylation/deacetylation by CBP/SIRT1
- Discovery and Characterization of Protein‐Modifying Natural Products by MALDI Mass Spectrometry Reveal Potent SIRT1 and p300 Inhibitors
- SIRT1 negatively regulates the protein stability of HIPK2
- Resveratrol administration or SIRT1 overexpression does not increase LXR signaling and macrophage-to-feces reverse cholesterol transport in vivo
- Expression and significance of SIRT1 and survivin in endometrial carcinoma
- Effects of exercise training duration on SIRT1 and eNOS expression in rat aortas
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- SRT2379, a small-molecule SIRT1 activator, fails to reduce cytokine release in a human endotoxemia model
- Hepatic SIRT1 and UCP2 expressions in rats with type 2 diabetes mellitus and nonalcoholic fatty liver
- miR-520c and miR-373 target mTOR and SIRT1, activate the Ras/Raf/MEK/Erk pathway and NF-κB, with up-regulation of MMP9 in human fibrosarcoma cells
- The modulation of SIRT1 expression by different types of high fat state in hepatocytes
- AMPK-SIRT1-PGC-1α signaling regulates mitochondrial function in human articular chondrocytes
- Role of SIRT1 in Resistance Exercise‐Induced Changes in Vascular Function
- SIRT1 knockout impairs the differentiation of adipocyte in C57BL/6J mice and its underlying mechanism
- Research progress of SIRT1 and osteoporosis
- Implications of a novel point mutation of SIRT1 in T1DM
- The role of SIRT1 in the activation of innate immune responses during RSV infection (68.6)
- Expressions and clinical significance of SIRT1, P53 and P-gp in gastric carcinoma.
- SIRT1 Activators in Development
- SIRT1‐independent epigenetic effects of resveratrol mediated through the estrogen receptor
- Pancreatic ductal cells acquire mesenchymal characteristics through cell fusion with bone marrow-derived mesenchymal stem cells and SIRT1 attenuates the apoptosis …
- Is a deceptive role of IGF-1 in SIRT1–PARP1 interactions the primary step of postnatal regression of hypertrophic cardiomyopathy in infants of diabetic mothers?
- Role of SIRT1/UCP2 signaling pathway in resveratrol-induced inhibition of oxidative injury in vascular endothelial cells
- Reproductive effects of SIRT1 expression in astrocytes
- Abstract P2-06-02: Pparg deacetylation by SIRT1 determines breast tumor lipid synthesis and growth
- Mammalian target of rapamycin (mTOR) sigaling pathway involved in the inhibition of silence information regulator1 (SIRT1) on fat deposition of mice.
- Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of MnSOD via the SIRT1/FoxO3a pathway
- Mutual inhibition between miR-34a and SIRT1 contributes to regulation of DNA double-strand break repair
- Importance of NAMPT-mediated NAD-biosynthesis and NAD-dependent deacetylase SIRT1 in the crosstalk between circadian rhythm and metabolism
- Electrochemical Immunosensor Based on AuNPs/PDDA-GO for Detection of SIRT1
- Expression of SIRT1 and P55PIK in Gastric Cancer and Clinical Significance
- SIRT1 deacetylase is essential for hematopoietic stem cell activity
- Metformin modulates hyperglycemia‐induced endothelial dysfunction through SIRT1
- PPARalpha/SIRT1 Complex is Involved in the Deterioration of Fatty Acid Metabolism During the Pathological Development of Heart Failure
- SIRT1 protects cortical neurons from shear stress induced mechanical injury
- GSPE enhance eNOS expression through AMPK/SIRT1–KLF2 pathway and modulate blood pressure in ouabain induced hypertensive rats
- Inhibition of SIRT1 Transcription in Resveratrol-differentiated Medulloblastoma Cells
- Construction of recombinant lentiviral vector of shRNA targeting SIRT1 gene and its effects on the proliferation of breast cancer cell
- SIRT1 Deacetylase Is Essential for Hematopoietic Stem Cell Activity Via Regulation of Foxo3.
- The role of melatonin in SIRT1 and p-AMPK regulation in HT-29 cell line
- Inhibition studies of SIRT1
- Leucine modulation of AMPK and mitochondrial biogenesis in C2C12 myotubes is SIRT1 dependent
- Relationship between SIRT1 expression in atrial tissue and atrial fibrosis in patients with atrial fibrillation
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- Research on the Morphological Changes of Ischemic Cell Mediated via SIRT1 Pathway in the Intervention with Xuefu Zhuyu Capsules
- Conjugated linoleic acid (CLA) activates PGC‐1alpha via AMPK and SIRT1 in C2C12 myotubes
- Hepatic deletion of SIRT1 decreases HNF1α/FXR signaling and induces formation of cholesterol gallstones in mice
- Caloric restriction ameliorates myocardial ischemia/reperfusion injury by suppressing complement activation in a SIRT1-dependent manner
- Research on Effect of SIRT1 on Ameliorating Lipid Metabolism Disorder of Type 2 Diabetic Rats after Exercise and Oral Resveratrol [J]
- Ezetimibe Inhibit Hyperacetylation of SREBP-1c in Lipid-Loaded Cells Derived from VSMC Required for SIRT1 [J]
- Tafluprost Protects Human Trabecular Meshwork Cells From Oxidative Stress Through The Activation Of C-myc/SIRT1 Transcription Pathway
- The Role of SIRT1 in Central Nervous System
- Pharmacological Inhibition Of The SIRT1 Deacetylase With The Small Molecule Inhibitor Tenovin-6 Enhances Ablation Of FLT3-ITD+ LSC In Combination With TKI …
- Adiponectin induces autophagic cell death in breast cancer cells through SIRT1 mediated deacetylation of LKB1 leading to ATG1 activation.
- Effects of SIRT1 on material metabolism and influence factors
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- Abstract A37: Beta-cryptoxanthin restores nicotine-reduced lung SIRT1 to normal levels and inhibits nicotine-promoted lung tumorigenesis and emphysema in A/J …
- THU0033 SET7/9 and SIRT1 induce promoter-driven collagen 2ALPHA1 expression in 3D cultured human chodrocytes
- SIRT1 limits the function and fate of myeloid-derived suppressor cells in
- SIRT1 as a Potential Therapeutic Target in Breast Cancer
- Research progress of SIRT1 in suppressing inflammatory response.
- Activation of SIRT1 by an N-terminal Regulatory Domain
- Examination of the reproductive effects of SIRT1 expression in neurons
- The deacetylase SIRT1 is down-regulated in gastric cancer and leads to G1 phase
- Role of SIRT1 in inflammation-associated carcinogenesis
- SIRT1: A novel target for treatment in cardiovascular diseases
- Roles of SIRT1 in tumorigenesis and tumor progression
- Expression of SIRT1 in tissues of patients with gastric carcinoma
- GW24-e2135 SIRT1 significantly influences Old sourced MSCs aging and proliferation
- Deciphering the role of 75kDa SIRT1 fragment in osteoarthritis
- The Role of SIRT1 in Preventing Mitochondrial Dysfunction with Obesity and Aging
- Research advances in SIRT1 regulating microRNA
- SIRT1-mediated suppression of cell death in breast cancer.
- Co-location of SIRT1 and IR in the adult mouse brain
- SIRT1 against breast cancer through downregulating Bcl-2 protein.
- Unravelling New Roles for SIRT1 in Mitochondrial Biollogy
- GW24-e3662 The comparative study on expression of SIRT1 signal transduction by Xuefuzhuyu capsule
- Functional complementation of sir2Δ yeast mutation by the human orthologous gene SIRT1
- THE LIPID SECOND MESSENGER PHOSPHATIDYLINOSITOL-5-PHOSPHATE STIMULATES SIRT1 DEACETYLASE ACTIVITY
- Isolation and Characterization of New Sirtuin1 (SIRT1) Activators from Medicinal Plants
- SIRT1 Inactivation Reduces Tumor Growth in Colon Cancer Model
- Role of adipose SIRT1 in regulating systemic energy metabolism
- Constitutive SIRT1 overexpression impairs mitochondria and
- Influence of Mailuoning on SIRT1 expression of brain tissue in Alzheimer′ s disease rat model
- The impact of SIRT1 inhibition on zebrafish morphology and behavior
- Recent Advances of Deacetylase SIRT1 on Apoptosis Regulation
- FLT3-ITD+ AML Stem/Progenitor Cells Demonstrate Increased SIRT1 Expression and Enhanced Sensitivity to SIRT1 Inhibition
- Supression of SIRT1 in angiogenesis of endothelial cells induced by HCMV infection
- Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinoma
- PPARdelta-SIRT1 Interaction Protects Endothelial Function in Diabetic Mice
- The neuroprotective effects of SIRT1 on NMDA-induced excitotoxicity
- Red Wine Molecule Makes a Comeback to Activate SIRT1
- Expression and significance of SIRT1 and p53 in endometrial carcinoma with diabetes mellitus
- SIRT1 Mediated Mitochondrial Biogenesis for The Protection of RGC-5 Cell During Oxidative Stress
- Leptin-induced SIRT1 expression: a potential linker between obesity and cancer
- Role of SIRT1 in regulation of hepatic gene expression by thyroid hormone
- The Role Of SIRT1 In The Pathogenesis Of Dry Age-related Macular Degeneration
- The Effects of SIRT1 SiRNA on the Bloodfat and Actived Platelets in Insulin Resistance Mice
- SIRT1 enhances Th17 cell generation by deacetylating RORγt (P1163)
- Expression of SIRT1 and p27 during progression of human cervical cancer
- Transgenic Mice Lacking SIRT1 or SIRT1 Catalytic Activity Exhibit Greater Susceptibility to Pulmonary Hypertension in Response to Chronic Hypoxia
- SIRT1 enhances endothelium‐dependent relaxation through an eNOS‐independent mechanism
- Original article SIRT1-deficient mice exhibit an altered cartilage phenotype
- Immunomodulation and Mechanism of Protein Deacetylase SIRT1
- Screening of SIRT1 activating compounds and their cytotoxicity in prostate cancer cell lines.
- PPARa Activation Inhibits Inflammatory Response in Endothelial Cells via the SIRT1-dependent Signaling Pathway
- Contrasting Effects of Enhanced SIRT1 Activity in Normal and BCR-ABL1-Depedent Haematopoiesis
- Regularity analysis of deacetylase SIRT1 expression in different pig organs and tissues
- Keratinocyte-specific deletion in mice reveals gene dose-dependent function of SIRT1 in tumorigenesis.
- Variant analysis of the Sirtuin [SIRT1] gene in multiple sclerosis
- AMPK-SIRT1 axis: a potential therapeutic target for prostate cancer management.
- Cloning and prokaryotic expression of SIRT1 gene from torafugu Takifugu rubripes
- SIRT1 silencing confers neuroprotection through IGF-1 pathway activation
- Inhibition of SIRT1 Impairs the Accumulation and Transcriptional Activity of HIF
- Interactions of SIRT1 with Acetyl Substrate, NAD+ or Nicotinamide
- Adipocyte-selective disruption of SIRT1 accelerates high fat diet
- Does resveratrol act independently of SIRT1 to affect genes relevant to ageing?
- Preliminary research of the relationship between coronary artery atherosclerosis and the genetic expression of AMPK and SIRT1
- MicroRNA-29c functions as a tumor suppressor by direct targeting endogenous SIRT1 in hepatocarcinogenesis
- SIRT1 Delays RGC Loss Following Optic Nerve Crush By Reducing Oxidative Stress
- SIRT1 links tumor suppressive NOTCH signaling to p53
- Mechanism of anti-proliferative effects of SIRT1 inhibition in melanoma cells: a proteomics approach.
- Expression and significance of SIRT1 and p53 in endometrial carcinoma with diabetes mellitus
- INHIBITION OF SIRT1 INDUCES APOPTOSIS IN BREAST CANCER STEM CELLS; POSTER PRESENTATION
- The signal pathway of SIRT1 underlying the neuroprotection in NMDA-induced excitotoxicity
- The novel SIRT1 activator srt3025 provides atheroprotection through increased hepatic low-density lipoprotein receptor expression
- Regulation of Skeletal Muscle Insulin Action by SIRT1 and STAT3
- Impact of SIRT1 silencing on DNA damage repair and chemoradiotherapy resistance in human pancreatic cancer
- Region-specific changes in the immunoreactivity of SIRT1 expression in the central nervous system of SOD1ᴳ⁹³ᴬ transgenic mice as an in vivo model of amyotrophic …
- Amelioration of Age-Related Vascular Dysfunction with SIRT1 Activation
- Changes of PGC-1α and SIRT1 expression in hippocampus of type 2 diabetes mellitus rats and its significance
- Effects of Endurance Exercise on Hepatic SIRT1 and PGC-1α Protein Expression in Ovariectomized Rats
- Metformin regulates hyperglycemia-induced vascular senescence through SIRT1
- Anti-aging Effects of Simvastatin on ox-LDL Induced Endothelial Cells Via Upregulation of SIRT1
- Strategies of SIRT1 enhancement against frailty in aging and neurodegeneration
- CDK5-MEDIATED HYPERPHOSPHORYLATION CONTRIBUTES TO THE LOSS-OF-SIRT1 FUNCTION DURING THE DEVELOPMENT OF ENDOTHELIAL …
- FRI0036 Epigallocatechin gallate modulates SIRT1 expression in CPP crystal-induced inflammation
- SIRT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a/PGC-1a complex in vascular endothelial cells
- Evaluation of energy requirement in growing Lanyu pigs and the role of hepatic SIRT1 under different caloric levels.
- Neuroprotective Role of Sirtuin (SIRT1) Against Hypoxia in Retinal Ganglion Cells
- GW24-e0624 Impairted cardiac SIRT1 activity by carbonyl stress increase susceptibility of aged hearts to ischaemia reperfusion injury
- Obesity Accelerates Ovarian Follicle Development and Loss through Supressing SIRT1 Signaling in Rats
- The Relation between Resveratrol, SIRT1, mTOR and Autophagy
- SIRT1 Protects Against Lung Endothelial Cell Dysfunction Following Particulate Matter Exposure
- Influence of chidamide on proliferation, apoptosis with expression of Notch1 and SIRT1 in gastric carcinoma cell line SGC-7901
- Eicosapentaenoic acid enhances nitric oxide production through up‐regulating SIRT1 expression in human endothelial cells
- Disruption of SIRT1 in chondrocytes causes accelerated development of osteoarthritis induced by joint instability in the mouse
- SIRT1 acutely modulates glucose sensing of POMC neurons in the hypothalamus
- SIRT1 Regulation of the Heat Shock Response in an HSF1-Dependent Manner and the Impact of Caloric Restriction
- Exploring the Possibility of Changes in SIRT1 Activity in Lipotoxicity-mediated β-cell Dysfunction
- Correction: SIRT1 Regulates Endothelial Notch Signaling in Lung Cancer
- Improvement Of Corneal Staining By A SIRT1 Activator In A Mouse Model Of Dry Eye
- NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells
- MicroRNA-34a regulates diabetes-induced impaired angiogenesis: Role of SIRT1
- Significance and expression of SIRT1 gene in human cervical endplate chondrocyte in vitro degeneration
- Silencing of Pericyte MicroRNA-132 Reduces Renal Fibrosis and Myofibroblast Proliferation and is Associated with Altered SIRT1 and Cox2 Expression
- The role of SIRT1/AKT/ERK pathway in ultraviolet B induced damage on human retinal pigment epithelial cells.
- Expression Of FLT3-ITD Dysregulates The DBC1-SIRT1-p53 Signaling and Promotes Therapy Resistance
- Targeted inhibition of SIRT1 histone deacetylase by small-molecule inhibitor Tenovin-1 imparts significant anti-proliferative effects in human melanoma cells
- Cloning and prokaryotic expression of SIRT1 gene from torafugu Takifugu rubripes.
- The CREB SIRT1 axis mediates Neural Stem Cells modulation by nutrient availability
- Duration-and concentration-dependent induction of SIRT1 on human degenerative endplate chondrocytes by Resveratrol
- Supplementary Figures The NAD+-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status
- The Histone Deacetylase SIRT1 Modulates STAT3 Activity and Prevents De-differentiation and Proliferation of Vascular Smooth Muscle Cells
- Sirtuin1 (SIRT1) regulates HBV transcription and replication by targeting transcription factor AP-1.
- OP0256 SIRT1 Regulates Cigarette Smoke-Induced IL8 Expression and TNFA-Mediated Il6 Release in Rheumatoid Arthritis Synovial Fibroblasts
- SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements
- New molecular insights in APE1 binding to nCaRE elements of gene promoters: identification of SIRT1 as novel target gene
- Abolished Daily Expression Patterns of SIRT1, SIRT2, and SIRT5 in Human Chronic Myeloid Leukemia
- SIRT1 is Associated with Age-related Susceptibility to Acute Kidney Injury caused by Ischemia-reperfusion in Mice
- The growth arrest and apoptosis of adult T-cell leukemia cell lines MT2 induced by SIRT1 deacetylases inhibitor.
- Moderate alcohol consumption alters hepatic AdipoR1/SREBP‐1c and SIRT1 activity in rats with pre‐existing NASH
- SIRT1 regulates cigarette smoke-induced production of reactive oxygen species in myocardial mitochondria: Role of resveratrol [J]
- Correlation between estrogen secretion and SIRT1 gene expression levels in porcine ovarian granulosa cells.
- SIRT1 Activators Attenuate RGC Cell Loss By Reducing Oxidative Stress In MHV-A59 Induced Optic Neuritis
- PGE2 cigarette smoke-induced modulates endothelial tissue factor: role of EP1 receptor and SIRT1
- Combined Effect of Flow‐Mediated Shear Stress and Resveratrol on SIRT1/PGC‐1α Pathway in Vascular Endothelial Cells.
- A SUMOylation-dependent pathway regulates SIRT1 transcription and cancer metastasis
- Dimer Conversion of PPARalpha/RXR To PPARalpha/SIRT1 Suppresses Fatty Acid Oxidation Genes
- Abstract A86: SIRT1 regulates Rac1-GTPase activation via the guanine nucleotide exchange factor TIAM1
- SIRT1 antagonizes Stra13 Mediated p53 Acetylation and Senescence
- Overcoming of radiochemoresistance in glioblastoma stem cells via inhibition of lipid catabolism and SIRT1 deacetylase.
- Fullerenol Protects RPE cells from Oxidative-stress Induced Premature Senescence via Activation of SIRT1
- Accelerated Senescence of Cord Blood Endothelial Progenitor Cells From Premature Neonates is Driven by SIRT1 Decreased Expression
- Sirtuin (SIRT1/Sirt2) protect human pluripotent stem cells from DNA damage-induced apoptosis
- AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver
- Age-Associated Reduction of SIRT1 in Vascular Smooth Muscle Accelerates Angiotensin II-Induced Vascular Aging and Abdominal Aortic Aneurysm in Mice
- SIRT1 Activation with SRT1720 Reverses Impaired Endothelium‐Dependent Dilation in Old Mice by Augmenting COX‐2 Mediated Vasodilation
- The Role of SIRT1 in Exercise-and Resveratrol-induced Muscle Mitochondrial Biogenesis
- Inflammation and apoptosis in the synovium of patients with rheumatoid arthritis: the role of SIRT1 and microRNA-34a
- Resveratrol Displays Cardioprotection in Postinfarction Remodeling Through Autophagic Activation Associated With Ampk but not SIRT1 Pathway
- Epigenetic Regulation of p66Shc by SIRT1 Causes Persistent Myocardial Oxidative Stress and Inflammation Despite Optimal Glycemic Control in Diabetes
- Quercetin can increase mRNA expression of PGC-1α and SIRT1, and mtDNA and cytochrome c in both skeletal muscle and brain.
- Thrombosis Protection In Klkb1-/- (Prekallikrein KO) Mice Is Mediated By Increased Renal Mas Receptor, Plasma Prostacyclin, and Aortic SIRT1
- Inhibition of SIRT1 Sensitizes TRAIL-Resistant MCF-7 Cells by Upregulation of DR5 and Inhibition of c-FLIP
- The stability and bifurcation of modeling micro RNA regulation in signaling networks: miR-34a regulation of the p53/SIRT1 module
- NAMPT/NAD+/SIRT1-Triggered Deacetylation Of Hematopoietic Cell-Specific Lyn-Substrate 1 (HCLS1) In Congenital Neutropenia
- Resveratrol-induced activation of the SIRT1/AMPK axis in human CD4 T cells triggers replicative stress and an ATR-dependent cell cycle arrest
- Abstract LB-133: A novel tumor suppressor role for SIRT1 inhibiting mitophagy in prostate mouse tissue.
- Abstract LB-266: SIRT1 governs GnRH neuron migration and The Kallmann syndrome phenotype.
- H2S and L‐Cysteine Increase the Glucose Utilization via the PIP3 Mediated Insulin Dependent (PI3K/AKT) and the Insulin Independent (SIRT1/AMPK/PPAR gamma) …
- 496 Transgenic Mice Lacking SIRT1 Catalytic Activity Exhibit Greater Susceptibility to Pulmonary Hypertension in Response to Chronic Hypoxia
- Lycopene metabolite, apo‐10′‐lycopenoic acid, inhibits diet‐induced obesity‐promoted liver carcinogenesis via the up‐regulation of SIRT1 signaling and the …
- POLY (ADP‐RIBOSE) POLYMERASE‐2 DEPLETION REDUCES DOXORUBICIN‐INDUCED DAMAGE THROUGH SIRT1 INDUCTION
- Hematopoietic-specific lyn-substrate 1 (HCLS) is deacetylated by NAMPT/NAD+/SIRT1 pathway
- HEMATOPOIETIC-SPECIFIC LYN-SUBSTRATE 1 (HCLS) IS DEACETYLAT-ED BY NAMPT/NAD+/SIRT1 PATHWAY
- Phosphodiesterase-5 (PDE-5) Inhibitor, Tadalafil, Activates NO/SIRT1/PGC-1 Signaling And Attenuates Mitochondrial Dysfunction In Type 2 Diabetic Hearts
- Linking lipids to acetylation novel roles of of PI (5) P and PIP4K in SIRT1 regulation and development
- PHOSPHATIDYLINOSITOL-5-PHOSPHATE 4 KINASE BETA (PIP4Kβ) BINDS TO AND IS DEACETYLATED BY SIRT1
- Resveratrol Inhibits IL-6-induced STAT3 Activation in Human Colon Epithelial Cells: SIRT1 as a Potential Target
- the effects of GLP-1 on SIRT1 and on the related metabolic pathways in vascular endothelial cells: potential effects on vascular injury in diabetic patients
- Effect of crocin-1 on learning, memory, and expression of SIRT1 in hippocampus of rats under acute hypoxia
- Angiogenesis Inhibitor Vasohibin-1 Prevents Paraquat-Induced Lung Injury Via The Induction Of SOD2 And SIRT1
- Linking the pro‐oxidant influences of epigallocatechin gallate (EGCG) to intestinal cholesterol metabolism via alterations in sirtuin 1 (SIRT1) using Caco‐2 cells
- Set7/9 represses SIRT1 to induce collagen type II expression in 3D cultured human chodrocytes
- Identification of Novel Acetylation Sites in Nrf1 (NFE2L1) and Their Regulation by Sirtuin 1 (SIRT1)
- Endothelial Overexpression of LOX-1 Protects From in vivo Arterial Thrombosis and Modulates Oct-1 and SIRT1 Expression
- TP 40 Implication of SIRT1 and its downstream pathways in dystrophic process
- … pancreatic beta cells from cytokine-induced apoptosis by both alleviating apoptotic pathways and activating anti-apoptotic pathways of Nrf2\2013HO-1 and SIRT1
- Sharp-1 Mediates p53-dependent cellular senescence through antagonism of SIRT1
- Structural and functional analysis of human SIRT1
- SIRT1 and other sirtuins in metabolism
- SIRT1 in cardiovascular aging
- Multifaceted modulation of SIRT1 in cancer and inflammation
- SIRT1 in neurodevelopment and brain senescence
- SIRT1 metabolic actions: integrating recent advances from mouse models
- Small molecule SIRT1 activators for the treatment of aging and age-related diseases
- SIRT1: role in cardiovascular biology
- The role of SIRT1 in cancer: the saga continues
- SIRT1 and NAD as regulators of ageing
- The role of SIRT1 in diabetic kidney disease
- SIRT1 Gene Polymorphisms Affect the Protein Expression in Cardiovascular Diseases
- SIRT1 in cerebral ischemia
- Diverse roles of SIRT1 in cancer biology and lipid metabolism
- SIRT1 and kidney function
- SIRT1 is decreased during relapses in patients with multiple sclerosis
- The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet
- SIRT1, a negative regulator of matrix metalloproteinase-9 in diabetic retinopathy
- A Remarkable Age-Related Increase in SIRT1 Protein Expression against Oxidative Stress in Elderly: SIRT1 Gene Variants and Longevity in Human
- Downregulation of SIRT1 as aging change in advanced heart failure
- Crystallographic structure of a small molecule SIRT1 activator-enzyme complex
- High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients
- SIRT1 positively regulates autophagy and mitochondria function in embryonic stem cells under oxidative stress
- P53 and SIRT1: routes of metabolism and genome stability
- SIRT1 deacetylates RORγt and enhances Th17 cell generation
- Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma
- An exploratory double‐blind, randomized clinical trial with selisistat, a SIRT1 inhibitor, in patients with H untington’s disease
- Epigenetic effects of natural polyphenols: A focus on SIRT1‐mediated mechanisms
- Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21
- SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome
- Molecular links between caloric restriction and Sir2/SIRT1 activation
- The N-terminal domain of SIRT1 is a positive regulator of endogenous SIRT1-dependent deacetylation and transcriptional outputs
- NAD+-dependent activation of SIRT1 corrects the phenotype in a mouse model of mitochondrial disease
- SIRT1 restrains lung inflammasome activation in a murine model of sepsis
- SIRT1 regulates YAP2-mediated cell proliferation and chemoresistance in hepatocellular carcinoma
- SIRT1/PGC1α-dependent increase in oxidative phosphorylation supports chemotherapy resistance of colon cancer
- SIRT1 in the brain—connections with aging-associated disorders and lifespan
- MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma
- Role of SIRT1 and AMPK in mesenchymal stem cells differentiation
- Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol
- Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma
- Metformin modulates hyperglycaemia‐induced endothelial senescence and apoptosis through SIRT1
- Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients
- SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function
- SIRT1 activation ameliorates renal fibrosis by inhibiting the TGF‐β/Smad3 pathway
- Hydrogen sulfide protects against apoptosis under oxidative stress through SIRT1 pathway in H9c2 cardiomyocytes
- Disruption of SIRT1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice
- SIRT1 suppresses doxorubicin-induced cardiotoxicity by regulating the oxidative stress and p38MAPK pathways
- The expression and correlation of SIRT1 and Phospho-SIRT1 in colorectal cancer
- Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: A mechanism including AMPKα1/SIRT1 [S]
- Adversity in childhood and depression: linked through SIRT1
- SIRT1 signalling protects mouse oocytes against oxidative stress and is deregulated during aging
- SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia
- Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis
- SIRT1 protects against myocardial ischemia–reperfusion injury via activating eNOS in diabetic rats
- Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway
- Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut
- Age-related loss of SIRT1 expression results in dysregulated human vascular smooth muscle cell function
- The NAD+-dependent SIRT1 deacetylase translates a metabolic switch into regulatory epigenetics in skeletal muscle stem cells
- Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through SIRT1 protein stabilization
- SIRT1 is involved in oncogenic signaling mediated by GPER in breast cancer
- Quercetin is a potent anti‐atherosclerotic compound by activation of SIRT1 signaling under oxLDL stimulation
- A potential treatment of non-alcoholic fatty liver disease with SIRT1 activators
- CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1
- Spinal SIRT1 activation attenuates neuropathic pain in mice
- Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells
- Shear stress regulates endothelial cell autophagy via redox regulation and SIRT1 expression
- Effect of caloric restriction on the SIRT1/mTOR signaling pathways in senile mice
- Identification, stability and expression of SIRT1 antisense long non-coding RNA
- A high-fat diet and NAD+ activate SIRT1 to rescue premature aging in cockayne syndrome
- SIRT1 suppresses the senescence-associated secretory phenotype through epigenetic gene regulation
- SIRT1 is required in the male germ cell for differentiation and fecundity in mice
- Relationship between mitochondrial DNA copy number and SIRT1 expression in porcine oocytes
- Role of SIRT1 during the ageing process: relevance to protection of synapses in the brain
- Age-dependent tissue expression patterns of SIRT1 in senescence-accelerated mice
- Expression of SIRT1 and oxidative stress in diabetic dry eye
- SIRT1 is a regulator of autophagy: Implications in gastric cancer progression and treatment
- Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats
- Effects of exercise and body temperature on eNOS, SIRT1, SIRT3 and Hsp70 expression in rat plantaris muscles (1164.6)
- The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice
- SIRT1-mediated eNAMPT secretion from adipose tissue regulates hypothalamic NAD+ and function in mice
- SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β
- The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome
- Fluoride induces oxidative damage and SIRT1/autophagy through ROS-mediated JNK signaling
- SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation
- Dendritic cell SIRT1–HIF1α axis programs the differentiation of CD4+ T cells through IL-12 and TGF-β1
- NiO nanoparticles induce apoptosis through repressing SIRT1 in human bronchial epithelial cells
- SIRT1 expression is associated with poor prognosis of lung adenocarcinoma
- SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism
- Intercellular interplay between SIRT1 signalling and cell metabolism in immune cell biology
- mTOR, AMPK, and SIRT1: key players in metabolic stress management
- Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver
- Dual role of SIRT1 in UVB-induced skin tumorigenesis
- SIRT1 deacetylates and stabilizes hypoxia-inducible factor-1α (HIF-1α) via direct interactions during hypoxia
- AMPK-dependent phosphorylation of GAPDH triggers SIRT1 activation and is necessary for autophagy upon glucose starvation
- Overexpression of SIRT1 in vascular smooth muscle cells attenuates angiotensin II-induced vascular remodeling and hypertension in mice
- SIRT1 protects pig oocyte against in vitro aging
- Radioprotective and antioxidant effect of resveratrol in hippocampus by activating SIRT1
- Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure
- SIRT1 is a regulator in high glucose-induced inflammatory response in RAW264. 7 cells
- New indole–isoxazolone derivatives: Synthesis, characterisation and in vitro SIRT1 inhibition studies
- Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice
- SIRT1 suppresses cardiomyocyte apoptosis in diabetic cardiomyopathy: an insight into endoplasmic reticulum stress response mechanism
- SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma
- SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer
- Leucine modulates mitochondrial biogenesis and SIRT1-AMPK signaling in C2C12 myotubes
- Resveratrol activates duodenal SIRT1 to reverse insulin resistance in rats through a neuronal network
- NAD+-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1
- SIRT1 suppresses self-renewal of adult hippocampal neural stem cells
- SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells
- Roles of microRNA-34a targeting SIRT1 in mesenchymal stem cells
- SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cells
- Role of SIRT1 in autoimmune demyelination and neurodegeneration
- Association of genetic variants of SIRT1 with type 2 diabetes mellitus
- SIRT1 inhibition in pancreatic cancer models: contrasting effects in vitro and in vivo
- Expression of SIRT1 and SIRT3 varies according to age in mice
- Caloric restriction, resveratrol and melatonin: role of SIRT1 and implications for aging and related-diseases
- Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia
- SIRT1 deletion leads to enhanced inflammation and aggravates endotoxin-induced acute kidney injury
- SIRT1 limits the function and fate of myeloid-derived suppressor cells in tumors by orchestrating HIF-1α–dependent glycolysis
- Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1‐BMAL1 pathway
- SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements
- A randomized, placebo-controlled study of SRT2104, a SIRT1 activator, in patients with moderate to severe psoriasis
- … resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression, including SIRT1-dependent γ-H2AX and …
- SIRT1 directly regulates SOX2 to maintain self‐renewal and multipotency in bone marrow‐derived mesenchymal stem cells
- The SIRT1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression
- Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity
- Role of SIRT1 in the growth and regulation of normal hematopoietic and leukemia stem cells
- SIRT1 mediates the effect of GLP-1 receptor agonist exenatide on ameliorating hepatic steatosis
- SIRT1 in B [a] P-induced lung tumorigenesis
- The deacetylase SIRT1 is an essential regulator of Aire-mediated induction of central immunological tolerance
- SIRT1-FOXO3a regulate cocaine actions in the nucleus accumbens
- Muscle-specific SIRT1 gain-of-function increases slow-twitch fibers and ameliorates pathophysiology in a mouse model of duchenne muscular dystrophy
- SIRT1 and AMPK mediate hypoxia-induced resistance of non–small cell lung cancers to cisplatin and doxorubicin
- SIRT1 is necessary for proficient telomere elongation and genomic stability of induced pluripotent stem cells
- SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin
- Age-associated weight gain, leptin, and SIRT1: a possible role for hypothalamic SIRT1 in the prevention of weight gain and aging through modulation of leptin …
- SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and …
- DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia
- The SIRT1/HIF2α axis drives reductive glutamine metabolism under chronic acidosis and alters tumor response to therapy
- SIRT1 knockdown promotes neural differentiation and attenuates the heat shock response
- Dysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemness
- ATGL-catalyzed lipolysis regulates SIRT1 to control PGC-1α/PPAR-α signaling
- SIRT1 regulates lamellipodium extension and migration of melanoma cells
- SIRT1 attenuates severe ischemic damage by preserving cerebral blood flow
- Modulation of SIRT1-Foxo1 signaling axis by resveratrol: implications in skeletal muscle aging and insulin resistance
- Diabetes causes bone marrow autonomic neuropathy and impairs stem cell mobilization via dysregulated p66Shc and SIRT1
- Leptin attenuates BACE1 expression and amyloid-β genesis via the activation of SIRT1 signaling pathway
- In vivo RNA interference models of inducible and reversible SIRT1 knockdown in kidney cells
- PRMT1 and PRMT4 regulate oxidative stress-induced retinal pigment epithelial cell damage in SIRT1-dependent and SIRT1-independent manners
- SIRT1 expression is associated with a poor prognosis, whereas DBC1 is associated with favorable outcomes in gastric cancer
- A phase II, randomized, placebo‐controlled, double‐blind, multi‐dose study of SRT2104, a SIRT1 activator, in subjects with type 2 diabetes
- Activation of SIRT1 by curcumin blocks the neurotoxicity of amyloid-β25–35 in rat cortical neurons
- SIRT1 counteracted the activation of STAT3 and NF-κB to repress the gastric cancer growth
- Accelerated senescence of cord blood endothelial progenitor cells in premature neonates is driven by SIRT1 decreased expression
- Differential roles of SIRT1 in HIF-1α and HIF-2α mediated hypoxic responses
- Sirtuin1 (SIRT1) promotes cortical bone formation by preventing β-catenin sequestration by FoxO transcription factors in osteoblast progenitors
- Resveratrol treatment restores peripheral insulin sensitivity in diabetic mice in a SIRT1‐independent manner
- SIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells
- Fasting protects liver from ischemic injury through SIRT1-mediated downregulation of circulating HMGB1 in mice
- The p53/miR-34a/SIRT1 positive feedback loop in quercetin-induced apoptosis
- Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1
- Interferon β protects against lethal endotoxic and septic shock through SIRT1 upregulation
- Resveratrol relieves ischemia‑induced oxidative stress in the hippocampus by activating SIRT1
- SIRT1 protects against oxidative stress‐induced endothelial progenitor cells apoptosis by inhibiting FOXO3a via FOXO3a ubiquitination and degradation
- Piceatannol and its metabolite, isorhapontigenin, induce SIRT1 expression in THP-1 human monocytic cell line
- Oxidative stress-induced inhibition of SIRT1 by caveolin-1 promotes p53-dependent premature senescence and stimulates the secretion of interleukin 6 (IL-6)
- Resveratrol induces vascular smooth muscle cell differentiation through stimulation of SIRT1 and AMPK
- The natural phytochemical dehydroabietic acid is an anti-aging reagent that mediates the direct activation of SIRT1
- Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1-NF-κB signaling pathway
- Correlation and prognostic value of SIRT1 and Notch1 signaling in breast cancer
- Association between the SIRT1 mRNA expression and acute coronary syndrome
- SIRT1 activation rescues doxorubicin-induced loss of functional competence of human cardiac progenitor cells
- Overexpression of SIRT1 induced by resveratrol and inhibitor of miR-204 suppresses activation and proliferation of microglia
- SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis
- Suppression of native defense mechanisms, SIRT1 and PPARγ, by dietary glycoxidants precedes disease in adult humans; relevance to lifestyle-engendered chronic …
- High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression
- NAD+-dependent SIRT1 deactivation has a key role on ischemia–reperfusion-induced apoptosis
- Attenuation of β‐amyloid‐induced tauopathy via activation of CK2α/SIRT1: Targeting for cilostazol
- Loss-of-SIRT1 function during vascular ageing: hyperphosphorylation mediated by cyclin-dependent kinase 5
- Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating SIRT1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-β1 in rat …
- Simvastatin attenuates TNF‑α‑induced apoptosis in endothelial progenitor cells via the upregulation of SIRT1
- Carbon monoxide protects against hepatic ischemia/reperfusion injury by modulating the miR-34a/SIRT1 pathway
- Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease
- Linking DNA damage, NAD+/SIRT1, and aging
- SIRT1 plays a protective role in intervertebral disc degeneration in a puncture-induced rodent model
- Calorie restriction attenuates cerebral ischemic injury via increasing SIRT1 synthesis in the rat
- Resveratrol increases brown adipose tissue thermogenesis markers by increasing SIRT1 and energy expenditure and decreasing fat accumulation in adipose tissue …
- Suppression of deacetylase SIRT1 mediates tumor-suppressive NOTCH response and offers a novel treatment option in metastatic Ewing sarcoma
- Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis
- Adiponectin promotes pancreatic cancer progression by inhibiting apoptosis via the activation of AMPK/SIRT1/PGC-1α signaling
- Maternal high-fat feeding increases placental lipoprotein lipase activity by reducing SIRT1 expression in mice
- Modulating effect of SIRT1 activation induced by resveratrol on Foxo1‐associated apoptotic signalling in senescent heart
- Sesamin ameliorates doxorubicin-induced cardiotoxicity: involvement of SIRT1 and Mn-SOD pathway
- SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activation
- SIRT1 activating compounds reduce oxidative stress mediated neuronal loss in viral induced CNS demyelinating disease
- Myeloid deletion of SIRT1 aggravates serum transfer arthritis in mice via nuclear factor-κB activation
- Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the SIRT1/AMPK and the Nrf2/antioxidant defense pathways in a …
- Metformin induces microRNA-34a to downregulate the SIRT1/Pgc-1α/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress …
- Ligand and structure-based approaches for the identification of SIRT1 activators
- Leishmania infantum Modulates Host Macrophage Mitochondrial Metabolism by Hijacking the SIRT1-AMPK Axis
- FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway
- Resveratrol protects against doxorubicin‐induced cardiotoxicity in aged hearts through the SIRT1‐USP7 axis
- Myeloid SIRT1 regulates macrophage infiltration and insulin sensitivity in mice fed a high-fat diet
- Ketosis may promote brain macroautophagy by activating SIRT1 and hypoxia-inducible factor-1
- Specific turn-on fluorescent probe with aggregation-induced emission characteristics for SIRT1 modulator screening and living-cell imaging
- SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling
- SIRT1 is upregulated in cutaneous T-cell lymphoma, and its inhibition induces growth arrest and apoptosis
- Over-expression of SIRT1 contributes to chemoresistance and indicates poor prognosis in serous epithelial ovarian cancer (EOC)
- Oct4 maintains the pluripotency of human embryonic stem cells by inactivating p53 through SIRT1‐mediated deacetylation
- MicroRNA-34a induces vascular smooth muscle cells senescence by SIRT1 downregulation and promotes the expression of age-associated pro-inflammatory …
- Flavonoid fraction of Bergamot juice reduces LPS-induced inflammatory response through SIRT1-mediated NF-κB inhibition in THP-1 monocytes
- Resveratrol-induced SIRT1 activation promotes neuronal differentiation of human bone marrow mesenchymal stem cells
- Safety, pharmacokinetics, pharmacogenomics and QT concentration− effect modelling of the SIRT1 inhibitor selisistat in healthy volunteers
- Distinctive role of SIRT1 expression on tumor invasion and metastasis in breast cancer by molecular subtype
- Pharmacological activation of AMPK ameliorates perivascular adipose/endothelial dysfunction in a manner interdependent on AMPK and SIRT1
- Resveratrol induced premature senescence is associated with DNA damage mediated SIRT1 and SIRT2 down-regulation
- … -specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways
- Reduced thrombosis in Klkb1−/− mice is mediated by increased Mas receptor, prostacyclin, SIRT1, and KLF4 and decreased tissue factor
- Resveratrol prevents doxorubicin-induced cardiotoxicity in H9c2 cells through the inhibition of endoplasmic reticulum stress and the activation of the SIRT1 …
- … of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1–p53 signaling pathways
- SIRT1 is a tumor promoter in lung adenocarcinoma
- Metabolomic profiling of the heart during acute ischemic preconditioning reveals a role for SIRT1 in rapid cardioprotective metabolic adaptation
- Cross-talk between SIRT1 and endocrine factors: effects on energy homeostasis
- SIRT1 promoter polymorphisms as clinical modifiers on systemic lupus erythematosus
- High glucose induces renal tubular epithelial injury via SIRT1/NF-kappaB/microR-29/Keap1 signal pathway
- SIRT1 mediated inhibition of VEGF/VEGFR2 signaling by Resveratrol and its relevance to choroidal neovascularization
- SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system
- Melatonin Improves Mitochondrial Function by Promoting MT1/SIRT1/PGC-1 Alpha-Dependent Mitochondrial Biogenesis in Cadmium-Induced Hepatotoxicity In Vitro
- Intra‐articular resveratrol injection prevents osteoarthritis progression in a mouse model by activating SIRT1 and thereby silencing HIF‐2α
- Salvianolic acid B protects against acute ethanol-induced liver injury through SIRT1-mediated deacetylation of p53 in rats
- Polydatin alleviates small intestine injury during hemorrhagic shock as a SIRT1 activator
- Dietary blueberry and bifidobacteria attenuate nonalcoholic fatty liver disease in rats by affecting SIRT1-mediated signaling pathway
- Activation of miR-34a/SIRT1/p53 signaling contributes to cochlear hair cell apoptosis: implications for age-related hearing loss
- SIRT1-deficiency causes defective protein quality control
- Korean Red Ginseng attenuates ethanol-induced steatosis and oxidative stress via AMPK/SIRT1 activation
- Novel downstream molecular targets of SIRT1 in melanoma: a quantitative proteomics approach
- Loss of SIRT1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer
- Transplantation of SIRT1-engineered aged mesenchymal stem cells improves cardiac function in a rat myocardial infarction model
- SIRT1 protects rat lung tissue against severe burn-induced remote ALI by attenuating the apoptosis of PMVECs via p38 MAPK signaling
- Metformin and resveratrol inhibited high glucose-induced metabolic memory of endothelial senescence through SIRT1/p300/p53/p21 pathway
- Kaempferol protects cardiomyocytes against anoxia/reoxygenation injury via mitochondrial pathway mediated by SIRT1
- miR-34a inhibits cell proliferation in prostate cancer by downregulation of SIRT1 expression
- Minireview: central SIRT1 regulates energy balance via the melanocortin system and alternate pathways
- SIRT1 relays nutritional inputs to the circadian clock through the Sf1 neurons of the ventromedial hypothalamus
- rhEPO affects apoptosis in hippocampus of aging rats by upregulating SIRT1
- The effects of resveratrol and SIRT1 activation on dystrophic cardiomyopathy
- Pyrroloquinoline quinone increases the expression and activity of SIRT1 and-3 genes in HepG2 cells
- A divergent role of the SIRT1-TopBP1 axis in regulating metabolic checkpoint and DNA damage checkpoint
- SIRT1-dependent myoprotective effects of resveratrol on muscle injury induced by compression
- SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth
- TNF‐α and LPS activate angiogenesis via VEGF and SIRT1 signalling in human dental pulp cells
- Macrophage‐specific NOX2 contributes to the development of lung emphysema through modulation of SIRT1/MMP‐9 pathways
- miR-195 regulates SIRT1-mediated changes in diabetic retinopathy
- Resveratrol induces expression of the slow, oxidative phenotype in mdx mouse muscle together with enhanced activity of the SIRT1-PGC-1α axis
- Hypothalamic SIRT1 in aging
- ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation
- Alpha-lipoic acid upregulates SIRT1-dependent PGC-1α expression and protects mouse brain against focal ischemia
- The SIRT1 activator SRT1720 attenuates angiotensin II-induced atherosclerosis in apoE−/− mice through inhibiting vascular inflammatory response
- High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased …
- Reduced SIRT1 expression correlates with enhanced oxidative stress in compensated and decompensated heart failure
- Effect of resveratrol, a SIRT1 activator, on the interactions of the CLOCK/BMAL1 complex
- A TagSNP in SIRT1 Gene Confers Susceptibility to Myocardial Infarction in a Chinese Han Population
- … acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway
- Activation of the SIRT1/p66shc antiapoptosis pathway via carnosic acid-induced inhibition of miR-34a protects rats against nonalcoholic fatty liver disease
- Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion
- SIRT1-mediated deacetylation of CRABPII regulates cellular retinoic acid signaling and modulates embryonic stem cell differentiation
- Resveratrol differentially regulates NAMPT and SIRT1 in hepatocarcinoma cells and primary human hepatocytes
- Genetic polymorphisms at SIRT1 and FOXO1 are associated with carotid atherosclerosis in the SAPHIR cohort
- Roles of SIRT1 in granulosa cell apoptosis during the process of follicular atresia in porcine ovary
- Resveratrol enhanced FOXO3 phosphorylation via synergetic activation of SIRT1 and PI3K/Akt signaling to improve the effects of exercise in elderly rat hearts
- SIRT1 expression in the cochlea and auditory cortex of a mouse model of age-related hearing loss
- α-Mangostin regulates hepatic steatosis and obesity through SIRT1-AMPK and PPARγ pathways in high-fat diet-induced obese mice
- Resveratrol inhibition of human keratinocyte proliferation via SIRT1/ARNT/ERK dependent downregulation of aquaporin 3
- Expression of SIRT1 in the ovaries of rats with polycystic ovary syndrome before and after therapeutic intervention with exenatide
- Recombinant human SIRT1 protects against nutrient deprivation-induced mitochondrial apoptosis through autophagy induction in human intervertebral disc …
- Exercise training enhanced SIRT1 longevity signaling replaces the IGF1 survival pathway to attenuate aging-induced rat heart apoptosis
- SIRT1 functions as an important regulator of estrogen-mediated cardiomyocyte protection in angiotensin II-induced heart hypertrophy
- SIRT1 inhibition by sirtinol aggravates brain edema after experimental subarachnoid hemorrhage
- Loss of SIRT1 promotes prostatic intraepithelial neoplasia, reduces mitophagy, and delays PARK2 translocation to mitochondria
- Neophobia, NQO1 and SIRT1 as premorbid and prodromal indicators of AD in 3xTg-AD mice
- Acetylation of HDAC1 and degradation of SIRT1 form a positive feedback loop to regulate p53 acetylation during heat-shock stress
- SIRT1 suppresses human T-cell leukemia virus type 1 transcription
- SIRT1 Polymorphisms Associate with Seasonal Weight Variation, Depressive Disorders, and Diastolic Blood Pressure in the General Population
- MiR-34a inhibits migration and invasion by regulating the SIRT1/p53 pathway in human SW480 cells
- Circadian control of fatty acid elongation by SIRT1 protein-mediated deacetylation of acetyl-coenzyme A synthetase 1
- SIRT1/PGC-1α signaling protects hepatocytes against mitochondrial oxidative stress induced by bile acids
- A BCL6/BCOR/SIRT1 complex triggers neurogenesis and suppresses medulloblastoma by repressing Sonic Hedgehog signaling
- SIRT1 activation ameliorates hyperglycaemia by inducing a torpor-like state in an obese mouse model of type 2 diabetes
- The effect of alcohol on SIRT1 expression and function in animal and human models of hepatocellular carcinoma (HCC)
- GABA protects pancreatic beta cells against apoptosis by increasing SIRT1 expression and activity
- Clinicopathological and prognostic role of SIRT1 in breast cancer patients: a meta-analysis
- Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation
- AROS has a context-dependent effect on SIRT1
- Inhibition of HMGB1-induced angiogenesis by cilostazol via SIRT1 activation in synovial fibroblasts from rheumatoid arthritis
- … antioxidant are regulated by mitochondrial balance of fusion and fission leading to mitophagy triggered by a signaling network of SIRT1-Sirt3-Foxo3-PINK1 …
- SIRT1 attenuates high glucose-induced insulin resistance via reducing mitochondrial dysfunction in skeletal muscle cells
- Liquid fructose downregulates SIRT1 expression and activity and impairs the oxidation of fatty acids in rat and human liver cells
- Involvement of AMPK/SIRT1 pathway in anti-allodynic effect of troxerutin in CCI-induced neuropathic pain
- Simiao pill ameliorates renal glomerular injury via increasing SIRT1 expression and suppressing NF-κB/NLRP3 inflammasome activation in high fructose-fed rats
- FoxM1 regulates SIRT1 expression in glioma cells
- Changed profile of microRNAs in acute lung injury induced by cardio-pulmonary bypass and its mechanism involved with SIRT1
- Fullerenol protects retinal pigment epithelial cells from oxidative stress–induced premature senescence via activating SIRT1
- … SIRT1 activators SRT2183 and SRT3025 inhibit RANKL-induced osteoclastogenesis in bone marrow-derived macrophages and down-regulate Sirt3 in SIRT1 …
- AGEs-RAGE system down-regulates SIRT1 through the ubiquitin-proteasome pathway to promote FN and TGF-β1 expression in male rat glomerular mesangial cells
- SIRT1-metabolite binding histone macroH2A1. 1 protects hepatocytes against lipid accumulation
- SIRT1 inhibition affects angiogenic properties of human MSCs
- Intestine-specific deletion of SIRT1 in mice impairs DCoH2–HNF-1α–FXR signaling and alters systemic bile acid homeostasis
- Luteolin exerts an anticancer effect on NCI-H460 human non-small cell lung cancer cells through the induction of SIRT1-mediated apoptosis
- Short‑term calorie restriction activates SIRT1‑4 and‑7 in cardiomyocytes in vivo and in vitro
- Curcumin attenuates hydrogen peroxide-induced premature senescence via the activation of SIRT1 in human umbilical vein endothelial cells
- Intracellular NAMPT–NAD+–SIRT1 cascade improves post-ischaemic vascular repair by modulating Notch signalling in endothelial progenitors
- Pancreas-specific SIRT1-deficiency in mice compromises beta-cell function without development of hyperglycemia
- Arsenic exposure disrupts epigenetic regulation of SIRT1 in human keratinocytes
- HuR and TIA1/TIAL1 are involved in regulation of alternative splicing of SIRT1 pre-mRNA
- SIRT1 inactivation evokes antitumor activities in NSCLC through the tumor suppressor p27
- Isocaloric pair-fed high-carbohydrate diet induced more hepatic steatosis and inflammation than high-fat diet mediated by miR-34a/SIRT1 axis in mice
- Molecular insights into SIRT1 protection against UVB-induced skin fibroblast senescence by suppression of oxidative stress and p53 acetylation
- Curcumin enhanced cholesterol efflux by upregulating ABCA1 expression through AMPK-SIRT1-LXRα signaling in THP-1 macrophage-derived foam cells
- Regulation of cell cycle regulators by SIRT1 contributes to resveratrol-mediated prevention of pulmonary arterial hypertension
- Nutraceutical activators of AMPK/SIRT1 axis inhibit viral production and protect neurons from neurodegenerative events triggered during HSV-1 infection
- Investigating the role of SIRT1-modulated oxidative stress in relation to benign paroxysmal positional vertigo and Parkinson’s disease
- Humulus japonicus extract exhibits antioxidative and anti‑aging effects via modulation of the AMPK‑SIRT1 pathway
- SIRT1 deacetylates TopBP1 and modulates intra-S-phase checkpoint and DNA replication origin firing
- SIRT1 inhibits adipogenesis and promotes myogenic differentiation in C3H10T1/2 pluripotent cells by regulating Wnt signaling
- KAP1 deacetylation by SIRT1 promotes non-homologous end-joining repair
- SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis
- Histone/protein deacetylase SIRT1 is an anticancer therapeutic target
- New SIRT1 activator from alkaline hydrolysate of total saponins in the stems-leaves of Panax ginseng
- The involvement of NFAT transcriptional activity suppression in SIRT1-mediated inhibition of COX-2 expression induced by PMA/Ionomycin
- Cilostazol upregulates autophagy via SIRT1 activation: reducing amyloid-β peptide and APP-CTFβ levels in neuronal cells
- SIRT1 gene variants are related to risk of childhood obesity
- Set7/9 Impacts COL2A1 Expression Through Binding and Repression of SIRT1 Histone Deacetylation
- Defective mitophagy in XPA via PARP-1 hyperactivation and NAD+/SIRT1 reduction
- Dammarane Triterpenes as Potential SIRT1 Activators from the Leaves of Panax ginseng
- Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer …
- Brown Alga Ecklonia cava Polyphenol Extract Ameliorates Hepatic Lipogenesis, Oxidative Stress, and Inflammation by Activation of AMPK and SIRT1 in High-Fat Diet …
- MicroRNAs and SIRT1: a strategy for stem cell renewal and clinical development?
- Calorie restriction prevents metabolic aging caused by abnormal SIRT1 function in adipose tissues
- The metabolic sensors FXRα, PGC‐1 α, and SIRT1 cooperatively regulate hepatitis B virus transcription
- Novel small-molecule SIRT1 inhibitors induce cell death in adult T-cell leukaemia cells
- Nicotinamide ameliorates palmitate-induced ER stress in hepatocytes via cAMP/PKA/CREB pathway-dependent SIRT1 upregulation
- Aspirin targets SIRT1 and AMPK to induce senescence of colorectal carcinoma cells
- SIRT1 and FOXO mediate contractile differentiation of vascular smooth muscle cells under cyclic stretch
- SIRT1 is required for oncogenic transformation of neural stem cells and for the survival of “cancer cells with neural stemness” in a p53-dependent manner
- Aspirin attenuates vinorelbine-induced endothelial inflammation via modulating SIRT1/AMPK axis
- Neuroprotective effects of resveratrol on damages of mouse cortical neurons induced by β‐amyloid through activation of SIRT1/Akt1 pathway
- Antagonistic crosstalk between SIRT1, PARP-1, and-2 in the regulation of chronic inflammation associated with aging and metabolic diseases
- Protective effects of icariin‑mediated SIRT1/FOXO3 signaling pathway on intestinal ischemia/reperfusion‑induced acute lung injury
- Calorie restriction inhibits ovarian follicle development and follicle loss through activating SIRT1 signaling in mice
- SIRT1-related inhibition of pro-inflammatory responses and oxidative stress are involved in the mechanism of nonspecific low back pain relief after exercise through …
- Fisetin induces SIRT1 expression while inhibiting early adipogenesis in 3T3-L1 cells
- Sensitization of chemo-resistant human chronic myeloid leukemia stem-like cells to Hsp90 inhibitor by SIRT1 inhibition
- Modulation of the AMPK/SIRT1 axis during neuronal infection by herpes simplex virus type 1
- Electroacupuncture upregulates SIRT1-dependent PGC-1α expression in SAMP8 Mice
- Peripheral leukocyte expression of the potential biomarker proteins Bdnf, SIRT1, and Psen1 is not regulated by promoter methylation in Alzheimer’s disease patients
- Chronic inhibition of phosphodiesterase 5 with tadalafil attenuates mitochondrial dysfunction in type 2 diabetic hearts: potential role of NO/SIRT1/PGC-1α signaling
- Prognostic role of SIRT1 in hepatocellular carcinoma
- Repression of SIRT1 promotes the differentiation of mouse induced pluripotent stem cells into neural stem cells
- Palmitate inhibits SIRT1-dependent BMAL1/CLOCK interaction and disrupts circadian gene oscillations in hepatocytes
- Sirtuin 1 (SIRT1) Deacetylase Activity and NAD+/NADH Ratio Are Imperative for Capsaicin-Mediated Programmed Cell Death
- Higher expression of SIRT1 induced resistance of esophageal squamous cell carcinoma cells to cisplatin
- TNFα regulates SIRT1 cleavage during ocular autoimmune disease
- Chikusetsu saponin IVa confers cardioprotection via SIRT1/ERK1/2 and Homer1a pathway
- SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: effect of starvation
- SIRT1 and Sirt6 mediate beneficial effects of rosiglitazone on hepatic lipid accumulation
- MiR-9a-5p regulates proliferation and migration of hepatic stellate cells under pressure through inhibition of SIRT1
- Polydatin protects hepatocytes against mitochondrial injury in acute severe hemorrhagic shock via SIRT1-SOD2 pathway
- Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of SIRT1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells
- Activation of PPAR alpha by fenofibrate inhibits apoptosis in vascular adventitial fibroblasts partly through SIRT1-mediated deacetylation of FoxO1
- Chronic pancreatitis and pancreatic cancer demonstrate active epithelial–mesenchymal transition profile, regulated by miR-217-SIRT1 pathway
- Visfatin/Nampt and SIRT1
- Sensitization of multidrug-resistant human cancer cells to Hsp90 inhibitors by down-regulation of SIRT1
- BET inhibition upregulates SIRT1 and alleviates inflammatory responses
- SIRT1 mediates the effect of the heme oxygenase inducer, cobalt protoporphyrin, on ameliorating liver metabolic damage caused by a high-fat diet
- SIRT1 mediates FOXA2 breakdown by deacetylation in a nutrient-dependent manner
- Homocysteine facilitates LOX-1 activation and endothelial death through the PKCβ and SIRT1/HSF1 mechanism: relevance to human hyperhomocysteinaemia
- Effects of resveratrol in patients with type 2 diabetes mellitus on skeletal muscle SIRT1 expression and energy expenditure
- Mitochondrial complex I deficiency enhances skeletal myogenesis but impairs insulin signaling through SIRT1 inactivation
- Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure
- Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors
- Programmed hyperphagia secondary to increased hypothalamic SIRT1
- Effects of long-term resveratrol-induced SIRT1 activation on insulin and apoptotic signalling in aged skeletal muscle
- Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance
- Cryptosporidium parvum induces SIRT1 expression in host epithelial cells through downregulating let-7i
- The protective effect of fenofibrate against TNF-α-induced CD40 expression through SIRT1-mediated deacetylation of NF-κB in endothelial cells
- Differential SIRT1 expression in hepatocellular carcinomas and cholangiocarcinoma of the liver
- Guignardins A–F, spirodioxynaphthalenes from the endophytic fungus Guignardia sp. KcF8 as a new class of PTP1B and SIRT1 inhibitors
- Inhibition of SIRT1 signaling sensitizes the antitumor activity of silybin against human lung adenocarcinoma cells in vitro and in vivo
- Intrathecal SRT1720, a SIRT1 agonist, exerts anti-hyperalgesic and anti-inflammatory effects on chronic constriction injury-induced neuropathic pain in rats
- Ubiquitin-specific peptidase USP22 negatively regulates the STAT signaling pathway by deubiquitinating SIRT1
- SIRT1-Deficient Mice Have Hypogonadotropic Hypogonadism due to Defective GnRH Neuronal Migration
- Fentanyl increases colorectal carcinoma cell apoptosis by inhibition of NF-κB in a SIRT1-dependent manner
- Vitamin C protected human retinal pigmented epithelium from oxidant injury depending on regulating SIRT1
- The miR-29b–SIRT1 axis regulates self-renewal of mouse embryonic stem cells in response to reactive oxygen species
- Loss of sirtuin 1 (SIRT1) disrupts skin barrier integrity and sensitizes mice to epicutaneous allergen challenge
- CPEB1 modulates differentiation of glioma stem cells via downregulation of HES1 and SIRT1 expression
- Nicotinic acid inhibits vascular inflammation via the SIRT1-dependent signaling pathway
- Structure-based drug design of small molecule SIRT1 modulators to treat cancer and metabolic disorders
- SIRT1 and STAT3 protect retinal pigmented epithelium cells against oxidative stress
- SIRT1 inhibition restores apoptotic sensitivity in p53-mutated human keratinocytes
- SIRT1 gene is associated with cardiovascular disease in the Iranian population
- SIRT1 Overexpression Maintains Cell Phenotype and Function of Endothelial Cells Derived from Induced Pluripotent Stem Cells
- Coumestrol induces mitochondrial biogenesis by activating SIRT1 in cultured skeletal muscle cells
- The comparative study on expression of SIRT1 signal transduction by Xuefuzhuyu capsule
- Globular adiponectin causes tolerance to LPS-induced TNF-α expression via autophagy induction in RAW 264.7 macrophages: involvement of SIRT1/FoxO3A …
- Hydrogen sulfide delays nicotinamide-induced premature senescence via upregulation of SIRT1 in human umbilical vein endothelial cells
- Divalproex sodium enhances the anti-leukemic effects of imatinib in chronic myeloid leukemia cells partly through SIRT1
- The protective effect of FGF21 on diabetes-induced male germ cell apoptosis is associated with up-regulated testicular AKT and AMPK/SIRT1/PGC-1α signaling
- Emodin inhibits HMGB1-induced tumor angiogenesis in human osteosarcoma by regulating SIRT1
- Effect of shikonin on multidrug resistance in HepG2: The role of SIRT1
- SIRT1 rescues the obesity induced by insulin‐resistant constitutively‐nuclear FoxO1 in POMC neurons of male mice
- Licochalcone suppresses LXRα-induced hepatic lipogenic gene expression through AMPK/SIRT1 pathway activation
- Protective effect of saponins extract from Panax japonicus on myocardial infarction: involvement of NF-κB, SIRT1 and mitogen-activated protein kinase signalling …
- Sirtuin 1 (SIRT1) activation mediates sildenafil induced delayed cardioprotection against ischemia-reperfusion injury in mice
- Acetylcholinesterase inhibitors and compounds promoting SIRT1 expression from Curcuma xanthorrhiza
- Correction: SIRT1 regulates insulin secretion by repressing UCP2 in pancreatic β cells
- Butyric acid-induced rat jugular blood cytosolic oxidative stress is associated with SIRT1 decrease
- … ‐3‐glucoside protects human umbilical vein endothelial cells against oxidized low‐density lipoprotein‐induced injury by autophagy upregulation via the AMPK/SIRT1 …
- MicroRNA-204-5p–mediated regulation of SIRT1 contributes to the delay of epithelial cell cycle traversal in diabetic corneas
- … functions as a potent suppressor of oncogene‐induced senescence in prostate cancer via its transcriptional co‐regulation of the CDKN1A (p21WAF1/CIP1) and SIRT1 …
- SIRT1 mediates a primed response to immune challenge after traumatic lung injury
- SIRT1 induction confers resistance to etoposide-induced genotoxic apoptosis in thyroid cancers
- Cilostazol suppresses β‐amyloid production by activating a disintegrin and metalloproteinase 10 via the upregulation of SIRT1‐coupled retinoic acid receptor‐β
- Angiotensin II induces mitochondrial oxidative stress and mtDNA damage in osteoblasts by inhibiting SIRT1–FoxO3a–MnSOD pathway
- SIRT1 overexpression in skeletal muscle in vivo induces increased insulin sensitivity and enhanced complex I but not complex II–V functions in individual …
- The role of SIRT1 in the pathogenesis of insulin resistance in skeletal muscle
- Silent information regulator 1 (SIRT1) promotes the migration and proliferation of endothelial progenitor cells through the PI3K/Akt/eNOS signaling pathway
- Lycopene-rich tomato oleoresin modulates plasma adiponectin concentration and mRNA levels of adiponectin, SIRT1, and FoxO1 in adipose tissue of obese rats
- MicroRNA 34a inhibits beige and brown fat formation in obesity in part by suppressing adipocyte fibroblast growth factor 21 signaling and SIRT1 function
- RhNRG-1β protects the myocardium against irradiation-induced damage via the ErbB2-ERK-SIRT1 signaling pathway
- The multifunctional sorting protein PACS-2 regulates SIRT1-mediated deacetylation of p53 to modulate p21-dependent cell-cycle arrest
- Enhancement of NAD+-dependent SIRT1 deacetylase activity by methylselenocysteine resets the circadian clock in carcinogen-treated mammary epithelial …
- A novel role of SIRT1 in gammaherpesvirus latency and replication
- Cooperative action of Cdk1/cyclin B and SIRT1 is required for mitotic repression of rRNA synthesis
- SIRT1 mediates the effects of a short-term high-fat diet on the heart
- Celecoxib Sensitizes Staphylococcus aureus to Antibiotics in Macrophages by Modulating SIRT1
- Silencing angiopoietin‐like protein 4 (ANGPTL4) protects against lipopolysaccharide‐induced acute lung injury via regulating SIRT1/NF‐kB pathway
- Dysregulated miR-34a–SIRT1–acetyl p65 axis is a potential mediator of immune activation in the colon during chronic simian immunodeficiency virus infection of …
- Role of SIRT1-mediated mitochondrial and Akt pathways in glioblastoma cell death induced by Cotinus coggygria flavonoid nanoliposomes
- Hepatic SIRT1-dependent gain of function of stearoyl-CoA desaturase-1 conveys dysmetabolic and tumor progression functions
- Endoplasmic reticulum (ER) stress induces sirtuin 1 (SIRT1) expression via the PI3K-Akt-GSK3β signaling pathway and promotes hepatocellular injury
- Di-(2-ethylhexyl) phthalate inhibits DNA replication leading to hyperPARylation, SIRT1 attenuation and mitochondrial dysfunction in the testis
- SIRT1 knockdown potentiates radiation-induced bystander effect through promoting c-Myc activity and thus facilitating ROS accumulation
- The SIRT1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice
- Reversible acetylation of Lin28 mediated by PCAF and SIRT1
- WRN translocation from nucleolus to nucleoplasm is regulated by SIRT1 and required for DNA repair and the development of chemoresistance
- Visfatin is involved in TNFα-mediated insulin resistance via an NAD+/SIRT1/PTP1B pathway in 3T3-L1 adipocytes
- SIRT1 affects DNA methylation of polycomb group protein target genes, a hotspot of the epigenetic shift observed in ageing
- SIRT1 attenuates PAF-induced MMP-2 production via down-regulation of PAF receptor expression in vascular smooth muscle cells
- SIRT1 is involved in decreased bone formation in aged apolipoprotein E-deficient mice
- SIRT1 synchs satellite cell metabolism with stem cell fate
- Fructose mediated non-alcoholic fatty liver is attenuated by HO-1-SIRT1 module in murine hepatocytes and mice fed a high fructose diet
- Vestibular rehabilitation ameliorates chronic dizziness through the SIRT1 axis
- A novel mutation in SIRT1-AS leading to a decreased risk of HCC
- Exendin-4 attenuates endoplasmic reticulum stress through a SIRT1-dependent mechanism
- Epigenetic regulation of angiotensin-converting enzyme 2 (ACE2) by SIRT1 under conditions of cell energy stress
- Depletion of sirtuin 1 (SIRT1) leads to epigenetic modifications of telomerase (TERT) gene in hepatocellular carcinoma cells
- Effects of nitric oxide synthase inhibition on fiber-type composition, mitochondrial biogenesis, and SIRT1 expression in rat skeletal muscle
- SIRT1 activation ameliorates aldara-induced psoriasiform phenotype and histology in mice
- Tenovin-6-mediated inhibition of SIRT1/2 induces apoptosis in acute lymphoblastic leukemia (ALL) cells and eliminates ALL stem/progenitor cells
- Potato protein hydrolysate attenuates high fat diet-induced cardiac apoptosis through SIRT1/PGC-1a/Akt signalling
- Functional sequence variants within the SIRT1 gene promoter in indirect inguinal hernia
- Central SIRT1 regulates body weight and energy expenditure along with the POMC-derived peptide α-MSH and the processing enzyme CPE production in diet-induced …
- Sirtuin-1 (SIRT1) is required for promoting chondrogenic differentiation of mesenchymal stem cells
- AAV8-mediated SIRT1 gene transfer to the liver prevents high carbohydrate diet-induced nonalcoholic fatty liver disease
- Enhancement in efferocytosis of oxidized low‑density lipoprotein-induced apoptotic RAW264. 7 cells through SIRT1-mediated autophagy
- Rhein promotes the expression of SIRT1 in kidney tissues of type 2 diabetic rat
- Gene expression profiling of SIRT1, FoxO1, and PPARγ in backfat tissues and subcutaneous adipocytes of Lilu bulls
- Comprehensive silencing of target-sharing microRNAs is a mechanism for SIRT1 overexpression in cancer
- Methylation gets into rhythm with NAD+-SIRT1
- Quantitative insights for the design of substrate-based SIRT1 inhibitors
- SIRT1 regulates autophagy and diploidization in parthenogenetic haploid embryonic stem cells
- Ubiquitinated sirtuin 1 (SIRT1) function is modulated during DNA damage-induced cell death and survival
- Dysregulated serum IL-23 and SIRT1 activity in peripheral blood mononuclear cells of patients with rheumatoid arthritis
- Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer
- Stem cell transplantation upregulates SIRT1 and antioxidant expression, ameliorating fatty liver in type 2 diabetic mice
- Regulation of HepG2 cell apoptosis by hepatitis C virus (HCV) core protein via the SIRT1–p53–bax pathway
- Genetic variation in SIRT1 is associated with lipid profiles but not with longevity in Ashkenazi Jews
- 5-Aminolevulinic acid-mediated sonodynamic therapy induces anti-tumor effects in malignant melanoma via p53-miR-34a-SIRT1 axis
- Dynamic partnership between TFIIH, PGC-1α and SIRT1 is impaired in trichothiodystrophy
- Resveratrol relieves hydrogen peroxide-induced premature senescence associated with SIRT1 in human mesenchymal stem cells
- Resveratrol attenuates morphine antinociceptive tolerance via SIRT1 regulation in the rat spinal cord
- Molecular characterization, expression profiles, and analysis of Qinchuan cattle SIRT1 gene association with meat quality and body measurement traits (Bos taurus)
- Endothelial cell senescence increases traction forces due to age-associated changes in the glycocalyx and SIRT1
- SIRT1 modulates miRNA processing defects in p53-mutated human keratinocytes
- Mitochondrial aldehyde dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile dysfunction: role of AMPK, SIRT1, and mitochondrial function
- Ectopic expression of miR-494 inhibited the proliferation, invasion and chemoresistance of pancreatic cancer by regulating SIRT1 and c-Myc
- Overexpression of SIRT1 is a poor prognostic factor for advanced colorectal cancer
- Acetylated 8-oxoguanine DNA glycosylase 1 and its relationship with p300 and SIRT1 in lens epithelium cells from age-related cataract
- Down-regulation of mir-221 and mir-222 restrain prostate cancer cell proliferation and migration that is partly mediated by activation of SIRT1
- SIRT1 interacts with and deacetylates ATP6V1B2 in mature adipocytes
- Central SIRT1 regulates body weight and energy expenditure along with the POMC-derived peptide α-MSH and the processing enzyme CPE production in diet-induced …
- Resveratrol inhibits hyperxia-induced cell apoptosis through up-regulating SIRT1 expression in HPAECs
- Acetylome analysis identifies SIRT1 targets in mRNA-processing and chromatin-remodeling in mouse liver
- Resveratrol Regulates the Quiescence‐Like Induction of Activated Stellate Cells by Modulating the PPARγ/SIRT1 Ratio
- Scrapie infection in experimental rodents and SMB-S15 cells decreased the brain endogenous levels and activities of SIRT1
- Suppression of RANKL-induced osteoclast differentiation by cilostazol via SIRT1-induced RANK inhibition
- MiR-132 inhibits expression of SIRT1 and induces pro-inflammatory processes of vascular endothelial inflammation through blockade of the SREBP-1c metabolic …
- Selenium nanoparticles involve HSP-70 and SIRT1 in preventing the progression of type 1 diabetic nephropathy
- Potent SIRT1 Enzyme-stimulating and Anti-glycation Activities of Polymethoxyflavonoids from Kaempferia parviflora
- Nicotinamide and resveratrol regulate bovine adipogenesis through a SIRT1-dependent mechanism
- Mass spectrometric studies on the in vivo metabolism and excretion of SIRT1 activating drugs in rat urine, dried blood spots, and plasma samples for doping control …
- Expression of SIRT1 and FoxP3 in classical Hodgkin lymphoma and tumor infiltrating lymphocytes: implications for immune dysregulation, prognosis and …
- JAZ (Znf346), a SIRT1-interacting protein, protects neurons by stimulating p21 (WAF/CIP1) protein expression
- The TRPA1 channel is a cardiac target of mIGF-1/SIRT1 signaling
- Taurine attenuates amyloid β 1–42-induced mitochondrial dysfunction by activating of SIRT1 in SK-N-SH cells
- Astragalus polysaccharides affect insulin resistance by regulating the hepatic SIRT1-PGC-1α/PPARα-FGF21 signaling pathway in male Sprague Dawley rats …
- MicroRNA-212 negatively regulates starvation induced autophagy in prostate cancer cells by inhibiting SIRT1 and is a modulator of angiogenesis and cellular …
- MicroRNA-449 suppresses proliferation of hepatoma cell lines through blockade lipid metabolic pathway related to SIRT1
- Resveratrol could reverse the expression of SIRT1 and MMP-1 in vitro
- Myeloid-specific deletion of SIRT1 increases hepatic steatosis and hypothalamic inflammation in mice fed a high-fat diet
- The SIRT1/TP53 axis is activated upon B-cell receptor triggering via miR-132 up-regulation in chronic lymphocytic leukemia cells
- Protective efficacy of carnosic acid against hydrogen peroxide induced oxidative injury in HepG2 cells through the SIRT1 pathway
- Insulin attenuates arsenic-induced neurite outgrowth impairments by activating the PI3K/Akt/SIRT1 signaling pathway
- Effect of nasal CPAP on SIRT1 and endothelial function in obstructive sleep apnea syndrome
- SIRT1 and HMGB1 Regulate the AGE-Induced Pro-Inflammatory Cytokines in Human Retinal Cells.
- miR-27b overexpression improves mitochondrial function in a SIRT1-dependent manner
- CTGF siRNA ameliorates tubular cell apoptosis and tubulointerstitial fibrosis in obstructed mouse kidneys in a SIRT1-independent manner
- Resveratrol restores sirtuin 1 (SIRT1) activity and pyruvate dehydrogenase kinase 1 (PDK1) expression after hemorrhagic injury in a rat model
- Myeloid-specific SIRT1 deletion aggravates hepatic inflammation and steatosis in high-fat diet-fed mice
- Role of SIRT1 in the protection of intestinal epithelial barrier under hypoxia and its mechanism
- SIRT1 downregulation enhances chemosensitivity and survival of adult T-cell leukemia-lymphoma cells by reducing DNA double-strand repair
- Donepezil attenuates high glucose-accelerated senescence in human umbilical vein endothelial cells through SIRT1 activation
- SIRT1 expression is associated with lymphangiogenesis, lymphovascular invasion and prognosis in pN0 esophageal squamous cell carcinoma
- … peroxisome proliferator-activated receptor-δ and-γ inhibit lipopolysaccharide-primed release of high mobility group box 1 through upregulation of SIRT1
- SIRT1 activity in peripheral blood mononuclear cells from patients with rheumatoid arthritis
- Chikusetsu saponin V attenuates MPP+-induced neurotoxicity in SH-SY5Y cells via regulation of SIRT1/Mn-SOD and GRP78/caspase-12 pathways
- … ‑enriched exopolysaccharides produced by Enterobacter cloacae Z0206 alleviate adipose inflammation in diabetic KKAy mice through the AMPK/SIRT1 …
- Identification of a novel polyprenylated acylphloroglucinol‑derived SIRT1 inhibitor with cancer‑specific anti-proliferative and invasion-suppressing activities
- Frizzled 7 expression is positively regulated by SIRT1 and β-catenin in breast cancer cells
- Emerging role of silent information regulator 1 (SIRT1) in hepatocellular carcinoma: a potential therapeutic target
- Ablation of Lgr4 enhances energy adaptation in skeletal muscle via activation of Ampk/SIRT1/Pgc1α pathway
- Effect of pure total flavonoids from citrus on hepatic SIRT1/PGC-1alpha pathway in mice with NASH
- Alteration in bioenergetic regulators, SIRT1 and Parp1 expression precedes oxidative stress in rats subjected to transient cerebral focal ischemia: molecular and …
- MiR-138 promotes smooth muscle cells proliferation and migration in db/db mice through down-regulation of SIRT1
- Fuzhisan, a chinese herbal medicine, suppresses beta-secretase gene transcription via upregulation of SIRT1 expression in N2a-APP695 cells
- SIRT1 is reduced in gastric adenocarcinoma and acts as a potential tumor suppressor in gastric cancer
- Enantioselective induction of SIRT1 gene by syringaresinol from Panax ginseng berry and Acanthopanax senticosus Harms stem
- Association of SIRT1 and tumor suppressor gene TAp63 expression in head and neck squamous cell carcinoma
- Single Nucleotide Polymorphisms of the Sirtuin 1 (SIRT1) Gene are Associated With age-Related Macular Degeneration in Chinese Han Individuals: A Case …
- CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase
- Morphoproteomics identifies constitutive activation of the mTORC2/Akt and NF-κB pathways and expressions of IGF-1R, SIRT1, COX-2, and FASN in peripheral …
- SIRT1 regulates microtubule dynamics through negative regulation of Plk1 in mitosis
- Synthesis and Characterization of 4,11-Diaminoanthra[2,3-b]furan-5,10-diones: Tumor Cell Apoptosis through tNOX-Modulated NAD+/NADH Ratio and SIRT1
- … the expression of adiponectin in 3T3-L1 adipocytes via the activation of silent mating type information regulation 2 homologue 1 (SIRT1)-deacetylase and peroxisome …
- The Effect of SIRT1 Gene Polymorphisms on Ambulatory Blood Pressure of Hypertensive Patients in the Kazakh Population
- Interaction between NLRP3 inflammasome and SIRT1/6: metabolomics approach
- Down-regulation of the miR-543 alleviates insulin resistance through targeting the SIRT1
- IL-15 is required for postexercise induction of the pro-oxidative mediators PPARδ and SIRT1 in male mice
- The effect of SIRT1 protein knock down on PGC-1α acetylation during skeletal muscle contraction
- Role of SIRT1 in Streptococcus pneumoniae-induced human β-defensin-2 and interleukin-8 expression in A549 cell
- The role of SIRT1 in bile acid regulation during calorie restriction in mice
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- A Nampt inhibitor FK866 mimics vitamin B 3 deficiency by causing senescence of human fibroblastic Hs68 cells via attenuation of NAD+-SIRT1 signaling
- SIRT1 promote GTM cell DSBs repair and resist cellular senescence
- PPARα agonist WY-14643 induces SIRT1 activity in rat fatty liver ischemia-reperfusion injury
- 3, 5, 4′-Tri-O-acetylresveratrol attenuates lipopolysaccharide-induced acute respiratory distress syndrome via MAPK/SIRT1 pathway
- VEGF receptor-2–linked PI3K/calpain/SIRT1 activation mediates retinal arteriolar dilations to VEGF and shear stress
- Resveratrol: brain effects on SIRT1, GPR50 and photoperiodic signaling
- Transgenic supplementation of SIRT1 fails to alleviate acute loss of nigrostriatal dopamine neurons and gliosis in a mouse model of MPTP-induced …
- Differential effect of estradiol and bisphenol A on Set8 and SIRT1 expression in prostate cancer
- Nontoxic-dose of deguelin induce NPMC+ aml cell differentiation by selectively targeting MT NPM1/SIRT1 instead of HDAC1/3
- Inflammation contributes to NKX3. 1 loss and augments DNA damage but does not alter the DNA damage response via increased SIRT1 expression
- Growth inhibition of human hepatocellular carcinoma by miRNA-204 via down-regulation of Bcl-2 and SIRT1 expression
- CYP epoxygenase metabolites of docosahexaenoic acid protect HL-1 cardiac cells against LPS-induced cytotoxicity through SIRT1
- … acid inhibits insulin-induced activation of sterol regulatory-element binding protein 1 and cyclooxygenase-2 expression through upregulation of SIRT1 in human colon …
- Vitamin D (VD) prevents oxidative stress via regulating NOX4/Nrf2/Trx signaling cascade and upregulates SIRT1‐mediated AMPK/IRS1/GLUT4 pathway and glucose …
- The effect of the SIRT1 2827 A> G polymorphism, resveratrol, exercise, age and occupation in Turkish population with cardiovascular disease
- Up-regulation of the Sirtuin 1 (SIRT1) and Peroxisome Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) Genes in White Adipose Tissue of Id1 Protein-deficient …
- Photobiomodulation on Bax and Bcl-2 Proteins and SIRT1/PGC-1α Axis mRNA Expression Levels of Aging Rat Skeletal Muscle
- Inhibition of P-TEFb by DRB suppresses SIRT1/CK2α pathway and enhances radiosensitivity of human cancer cells
- The SIRT1 promoter polymorphic site rs12778366 increases IL-6 related human mortality in the prospective study “Treviso Longeva (TRELONG)”
- Upregulation of Unc-51-like kinase 1 by nitric oxide stabilizes SIRT1, independent of autophagy
- Improved Expression of SIRT1 on Thymic Epithelial Cells of SAMP10 after Intrabone Marrow–Bone Marrow Transplantation
- β-Lapachone ameliorates murine cisplatin nephrotoxicity: NAD+, NQO1, and SIRT1 at the crossroads of metabolism, injury, and inflammation
- SIRT1 contributes to aldose reductase expression through modulating NFAT5 under osmotic stress: In vitro and in silico insights
- MiR-34a inhibits beige and brown fat formation in obesity in part by suppressing adipocyte FGF21 signaling and SIRT1 function
- SIRT1 silencing suppresses prostate cancer growth and metastasis in an orthotopic prostate cancer mouse model
- SIRT1 inhibition suppresses multiple sclerosis
- The cytokine homeostasis was regulated by over-expression of SIRT1 in collagen-induced arthritis mice
- The role of SIRT1 in the treatment of diabetic nephropathy
- Structure–activity relationship and interaction studies of new SIRT1 inhibitors with the scaffold of 3-(furan-2-yl)-[1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazole
- The influence of ethnicity in the association of WC, WHR, hypertension and PGC-1α (Gly482Ser), UCP2− 866 G/A and SIRT1− 1400 T/C polymorphisms with T2D in …
- Rosuvastatin improves insulin sensitivity in overweight rats induced by high fat diet. Role of SIRT1 in adipose tissue
- Effects of Vam3 on sodium nitroprusside-induced apoptosis and SIRT1 and p53 expression in rat articular chondrocytes
- RETRACTED: Role of mammalian sirtuin 1 (SIRT1) in lipids metabolism and cell proliferation of goose primary hepatocytes
- Retraction Notice to: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10
- SIRT1 and rRNA in the nucleolus: regulating the regulator
- Effect of SIRT1 on cellular apoptosis and steroidogenesis in bovine ovarian granulosa cells in vitro
- Effects of single and combined genotypes of SIRT1 and SIRT2 genes on meat quality traits in Qinchuan cattle.
- Phosphoproteomics combined with quantitative 14-3-3-affinity capture identifies SIRT1 and RAI as novel regulators of cytosolic double-stranded RNA …
- CD150− Side Population Defines Leukemia Stem Cells in a BALB/c Mouse Model of CML and Is Depleted by Genetic Loss of SIRT1
- Docosahexaenoic acid inhibits white Adipogenesis and enhances mitochondrial biogenesis through SIRT1 and Hh signaling
- SIRT1 and Osteoarthritis. Comments on the Paper by Gabay Et Al.:” SIRT1-deficient Mice Exhibit an Altered Cartilage Phenotype”, Joint Bone Spine 2013
- Novel therapies for cancer treatment: designing high affinity and selectivity ligands against SIRT1
- A knockout Combo: eradicating AML Stem Cells with TKI plus SIRT1 inhibition
- Valproic acid suppresses SIRT1 inducing hepatotoxicity
- SIRT1, IGFBP-3 and CAV1 promoter DNA methylation in aging
- Benzothiazole derivatives upregulate SIRT1 and relevant genes in high-fat fed C57BL/6J mice
- Modulation of tumorigenesis by dietary intervention is not mediated by SIRT1 catalytic activity
- Synthesis of four SIRT1 activators based on an imidazo [1, 2-b] thiazole structure, in vitro derived metabolites and deuterated analogs
- Cigarette smoke impairs SIRT1 activity and promotes pro-inflammatory responses in bronchial epithelial cells
- microRNA‐34a mediates impaired angiogenesis in diabetes: role of SIRT1 and metformin (1051.2)
- Effect of a new dietary SIRT1 activator on high fat diet‐induced obesity and the involvement of microRNAs
- Cinnamon polyphenols increase oxygen‐glucose deprivation of decreased PGE2 production by upregulation of SIRT1 and alleviation of the anti‐inflammatory effects …
- Correlation between polymorphisms of SIRT1 gene and carcass traits in beef cattle.
- Mammary gland-specific deletion of SIRT1 delays mammary tumor growth and progression
- Analysis of expression Of SIRT1 gene in patients with chronic myeloid leukemia resistant to imatinib mesylate
- Correction: SIRT1 is a regulator in high glucose-induced inflammatory response in RAW264. 7 Cells
- High dose of epigallocatechin-3-gallate inhibits proliferation and induces apoptosis of H9C2 cardiomyocytes through down-regulation of SIRT1
- A TiO 2-Au–polymer hybrid system for the photoelectrochemical immunoassay of SIRT1
- SIRT1 as a key factor for histone code establishment in early embryo, from a perspective of assisted reproduction
- Danshensu delays the senescence of rat aortic endothelial cells via activation of SIRT1-SOD pathway
- GW25-e1653 SIRT1 enhances therapeutic efficacy of aged mesenchymal stem cells in rat myocardial infarction via lightening MSCs aging and heightening stress …
- Genistein promotes a gene expression profile characteristic of brown rather than white adipocytes and increases SIRT1 expression in mouse NIH3T3‐L1 cells (372.7)
- Regulation of neurons in the dorsal motor nucleus of the vagus by SIRT1
- 17β-Estradiol attenuates hematoma expansion through ERα/SIRT1/NF-κB pathway in hyperglycemic intracerebral hemorrhage mice
- GW25-e2369 Lipoic acid inhibits oxidative stress-induced premature senescence via upregulation of SIRT1 in human umbilical vascular endothelial cells
- OP0216 Resveratrol ameliorates pulmonary fibrosis and inhibits human lung fibroblasts activation VIA modulating SIRT1 and GLI1 signaling
- Research progress on SIRT1-FoxO-autophagy pathway
- Crystallographic Structure of a Small Molecule SIRT1 Activator/Enzyme Complex
- Correction: Globular Adiponectin Causes Tolerance to LPS-Induced TNF-α Expression via Autophagy Induction in RAW 264.7 Macrophages: Involvement of SIRT1 …
- SIRT1 and Inflammaging in Chronic Obstructive Pulmonary Disease
- P79 SIRT1 modulates endoplasmic reticulum stress-induced autophagy in heart.
- Effects of dietary restriction on antioxidant capacity and SIRT1 expression in hyperlipideima mice
- Construction of elderly SIRT1 gene knockout mouse models of knee osteoarthritis
- Tetramethylpyrazine (TMP) switches energy signalling from the PKCζ-GLUT4-glucose pathway back to the SIRT1-CD36-fatty acid pathway similar to …
- PPARα Association With SIRT1 Suppresses Cardiac Fatty Acid Metabolism in the Failing Heart
- AB199. Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats
- Jamming Up the “β-Staple”: Regulation of SIRT1 Activity by Its C-Terminal Regulatory Segment (CTR)
- GW25-e3514 resveratrol alleviates diabetic cardiomyopathy through improvement of mitochondrial biogenesis and function in a SIRT1-dependent manner
- Protective effect of SIRT1 on rat mesangial cells by decreasing high glu-cose-induced acetylation of NF-κB p65
- Hyperoxia induces reactive oxygen species production and promotes SIRT1 nucleocytoplasmic shuttling of peripheral blood mononuclear cells in premature infants in …
- Podocyte SIRT1 Deficiency Contributes to Albuminuria and Renal Fibrosis in Diabetic Kidney Damage in Mice
- Research progression of SIRT1
- SIRT1 inhibits related protein expression of endoplasmic reticulum stress in myocardial ischemic/reperfusion by activation of ERK1/2 pathway in rat
- Expression of SIRT1, Sirt2, Sirt5, and Sirt6 in the Mouse Testis
- ChREBP, SIRT1 and ethanol metabolism–a complicated network in alcohol-induced hepatic steatosis
- A high-fat meal alters post-prandial mRNA expression of SIRT1, SIRT4, and SIRT6
- Expression of SIRT1 in mouse testes
- Leucine-Metformin Synergy Activates the AMPK/SIRT1 Pathway to Increase Insulin Sensitivity in Skeletal Muscle and Glucose and Lipid Metabolism and Lifespan …
- Upregulation of Cardiac MicroRNA 34a, SIRT1, and Notch1 Following Oral Ingestion of Beetroot Juice and Doxorubicin Treatment: A Novel Protective Signaling Against …
- Synthesis of a SIRT1 Inhibitor
- SIRT1 in vascular related diseases: its progress
- Functional mechanism of SIRT1 gene in tumor
- Prognostic role of SIRT1 in hepatocellular carcinoma
- Expression and clinical significance of SIRT1 in hepatocellular carcinoma
- Research Progress of SIRT1 in Hepatic Injury
- Abstract P2-06-08: SIRT1 inhibitors significantly reduce cancer stem cells and block epithelial mesenchymal transformation in breast cancer cells
- Expression and its significance of SIRT1-FL and its alternative splicing variant SIRT1-△ Exon7 in rat hippocampus and cortex
- AB200. SIRT1 expression is elevated in human prostate cancer
- Construction of SIRT1 promoter expression vector and its activity analysis as well as influence of AML1-ETO on transcriptional regulation of SIRT1 gene
- SIRT1: A New Promising Drug Target
- The expression of SIRT1 in brainstem of rats in different types of hypoxia and its significance
- Study on the Differential Expressions of SIRT1 Gene in Ovine Tissues and Organs
- Construction and verification of SIRT1 and its mutant T200I, E420K eukaryotic expression vector
- The role of SIRT1 for regulating VEGF in human RPE
- SIRT1 is decreased during relapses in patients with multiple sclerosis
- Role of SIRT1 in Vascular Complications of Diabetes
- Expression of SIRT1 in bone marrow biopsy tissues and its clinical significance among children with acute myeloid leukemia
- A novel small-molecule SIRT1 inhibitor induces apoptosis in leukemic cell lines
- The progress in the study of SIRT1 effect on the bone repair of mesenchymal stem cells
- MicroRNA-455 targets SIRT1
- The Study of SIRT1 Regulatory Mechanism in DNA Repair Pathway Choice
- SIRT1 Negatively Regulates Cardiac Inflammation Induced by Metabolic Stress
- Effect of Estrogen on Expression of SIRT1 in Ovariectomized Rats
- SIRT1 differently regulates oncogenesis by diverse p53 types in hepatocellular carcinoma
- Age-related Expression of SIRT1 in the Cochlea of C57BL/6 Mice
- Correlation and prognostic value of SIRT1 and Notch1 signaling in breast cancer
- Corrigendum to “SIRT1 Inhibition Affects Angiogenic Properties of Human MSCs”
- Effect of SIRT1 siRNA interference on the expression of IL-6 after radiation
- Research Progress of Estrogen Upregulation of SIRT1 Activity in Anti-aging
- The roles played by the transcriptional regulators PPARalpha, HIF-1alpha and SIRT1 in the control of cardiac metabolism
- Progress in Stat3 and SIRT1 gene in the pathogenesis of rheumatoid arthristis
- Regulation of Acute KSHV Infection by SIRT1
- 1, 25 Dihydroxyvitamin D3 protects the heart against pressure overload-induced hypertrophy without affecting SIRT1 mRNA level
- SIRT1 Overexpression Together with EX527 Reduce Excitotoxicity-Induced Neuronal Loss in Cortical Neurons
- Action machanism of SIRT1 involves TNF-α-induced intestinal epithelial barrier destroy
- SIRT1 nutrient signaling regulates fetal programming of nephrogenesis (1033.10)
- SIRT1, A Negative Regulator of Matrix Metalloproteinase-9 in Diabetic Retinopathy
- Loss of SIRT1 Function Improves Intestinal Anti-Bacterial Defense and Protects
- Protein Deacetylases SIRT1 and Epigenetic Modification of Matrix Metalloproteinase-9 in Diabetic Retinopathy
- SIRT1 mRNA Phasic Expresson During C2C12 Myoblast Proliferation
- SIRT1 gene variants are related to risk of childhood obesity
- Suppression of HTLV-1 transcription by SIRT1 deacetylase
- Effects of SIRT1 mutation or over-expression in astrocytes on metabolism and reproduction
- Effect of SIRT1 on cell proliferation and senescence of human pancreaticβ-cells CRL-1837
- Role of genetic variations at SIRT1 and FOXO1 genes in carotid atherosclerosis
- The nuclear protein bovine SIRT1 is regulated by resveratrol and nicotinamide
- Dysregulation of SIRT1 Activity in the Pathogenesis of Huntington’s Disease
- Maturation conditions do not affect Myst1, Hat1, and SIRT1 mRNA abundance in horse oocytes
- Preventing disease and preserving health with moxibustion and ‘longevity gene’SIRT1
- Role of SIRT1 During the Ageing Process: Relevance to Protection of Synapses in the Brain
- Differential roles of SIRT1 in HIF‐1a and HIF‐2a mediated hypoxic responses (LB269)
- Expression of SIRT1 and Related Oxidative Stress in Diabetic Dry Eye Mouse
- P0913Astrocytic Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Extremely Low Frequency Electromagnetic Field through Modulating SIRT1
- Evaluating cathepsin activity and SIRT1 cleavage in experimental osteoarthritis
- The role of an NAD-dependent deacetylase SIRT1 in cellular response to kidney injury
- SIRT1 upregulators from high‐throughput screening as anti‐proliferation and anti‐migration agents in vascular smooth muscle cells (654.2)
- Cardiac SIRT1 Deficiency Sensitizes Myocardium to Ischemia and Reperfusion Injury
- DNA sequences differentially associated with SIRT1 and Dnmt3b during melanoma progression
- Expression of c-Myc, SIRT1 and acetyl-p53 in breast carcinoma and prognostic significance
- Relationship between expression of SIRT1 and SIRT6 genes and the response to ovarian stimulation
- SIRT1 contributes to LPS-induced lung injury through interaction with mitochondrial ROS generation
- GW26-e1360 Effects of SIRT1 on Protection Against Atherosclerosis Plaque via Anti-angiogenesis in Mice
- Apolipoprotein E4 and SIRT1 Interaction in Alzheimer’s Disease
- Modulating the Vascular Healing Response via SIRT1 Transgene Delivery
- Targeting SIRT1 and Its Pathway for Therapeutic Intervention of Cancer: Drug Design and Biological Evaluation
- The Protective Role of SIRT1 Activator in Renal Tubulointerstitial Fibrosis and Its Mechanism
- ANALYSIS OF EXPRESSION OF SIRT1 GENE IN PATIENTS WITH CHRONIC MYELOID LEUKEMIA RESISTANT TO IMATINIB MESYLATE
- Metformin alleviates hepatosteatosis through SIRT1-mediated autophagy induction
- Correction: Functional Complementation of sir2Δ Yeast Mutation by the Human Orthologous Gene SIRT1
- The tissue specific role of SIRT1 in joint inflammation and anabolic cartilage gene expression
- SRT1720, a SIRT1 activator, Attenuates Organ Injury and Inflammatory Response in Sepsis
- Synthesis and SIRT1 modulation studies of amides and hydrazides of benzoic acid incorporating a (2-trifluoromethylpyridin-4-yl) amino moiety
- #VALUE!
- The role of SIRT1 on the crosstalk of p65 and NFATS in U937 monocytes under hyperosmotic stress
- Effect of SIRT1 regulating cholesterol synthesis in repairing retinal ganglion cells after optic nerve injury in rats
- SIRT1 as a Novel Regulator of Cardiac Na+ Channels: A Potential Therapeutic Target for Arrhythmia
- B46 HEALTH EFFECTS OF AIR POLLUTION AND NANOPARTICLES: SIRT1 Protects Against Particulate Matter-Induced Lung Injury
- Survival of colorectal cancer cells following chemotherapy relies on a SIRT1-dependent increase in oxidative phosphorylation
- The natural phytochemical dehydroabietic acid is an anti-aging reagent that mediates the direct activation SIRT1
- Research on Effect of SIRT1 on Ameliorating Hepatic Lipid Metabolism Disorder of APOE~(-/-) after Aerobic Exercise
- SIRT1 in the Cardiomyocyte Counteracts Doxorubicin Cardiotoxicity in vivo
- SIRT1 suppresses the senescence-associated secretory phenotype through epigenetic gene regulation
- Role of SIRT1 in renal ischemia-reperfusion injury and its effect on NF-κBp65-PGC-1α signal pathway in mice
- A novel potential prognostic marker SIRT1 on tumor invasion and metastasis, and tumor recurrence in triple negative breast cancer
- Moderate SIRT1 Overexpression Protects against High Fat Diet Induced Insulin Resistance and Mitochondrial Dysfunction
- OP0267 SIRT1 Regulates Canonical Tgf-Beta Signaling to Control Fibroblast Activation and Tissue Fibrosis
- Effects of NLRP3 and IL-1β on radiation-induced expression through SIRT1 gene silencing
- Design and Synthesis of 2-Arylbenzothiazole Analogues as Novel SIRT1 Activators
- Starvation-Mediated Autophagy Attenuates Liver Ischemia Reperfusion Injury By SIRT1 in Mice.: Abstract# C1644
- Danshensu Delays the Senescence of Rat Aortic Endothelial Cells through SIRT1-SOD Signal Pathway
- #VALUE!
- Differential roles of SIRT1 in HIF-1αand HIF-2αmediated hypoxic responses
- A Clinical study on activity of NAMPT and SIRT1 gene expression in neutropenia with cancer chemotherapy
- Expression of apoptosis factors in porcine ovarian granulosa cells affected by SIRT1.
- SIRT1 Expression Is Higher in Human Follicular Lymphoma and Correlates with Ki67 and Bcl-6 Overexpression
- Functional analysis of SIRT1-interacting protein JAZ (Znf346) in neurons
- Sirtuin1 (SIRT1) is a Neuroprotectin D1 (NPD1) target in retinal pigment epithelial cell survival signaling
- A60 OUTCOMES OF SLEEP DISORDERED BREATHING AND SLEEP LOSS: Effect Of Treatment By Nasal Cpap On SIRT1 And Endothelial Function In Obstructive …
- SIRT1 Regulates Cell Survival, Collagen VI Expression of Human TM Cells and Permeability Of Endothelial Cells of Schlemm’s Canal
- The effects of SIRT1 on hypoxia induced by cobalt chloride in human fetal retinal pigment epithelial cells
- SIRT1 overexpression ameliorates TGF-β_1-induced human kidney proximal tubular cell apoptosis by inhibiting CTGF
- A21 THE MESENCHYME AND THE EPITHELIUM IN AIRWAY INFLAMMATION: SIRT1 Attenuates Nasal Polypogenesis By Suppressing Hypoxia-Inducible Factor-1 …
- SIRT1 deacetylates RORγt and enhances Th17 cell generation
- SIRT1 activators promote neuronal differentiation in human bone marrow mesenchymal stem cells
- SIRT1 overexpression protects against high fat diet‐induced cerebral artery endothelial dysfunction (1070.10)
- The Protective Role of AMPK/SIRT1/PGC-1α Signalling in Retinal Astrocytes
- SIRT1 Expression in B-Cell Acute Lymphoblastic Leukemia and Dose-Dependent Effect of Vorinostat
- SIRT1 in the Ventromedial Hypothalamus: A Nutrient Sensor Input Into the Internal Timekeeper
- Investigating the Potential Role of SIRT1 in Glioblastoma Multiforme: A Comparison Between Glioma and Normal Astrocyte Cells in Culture
- Effect of SIRT1 on high glucose-induced NF-κB p65 subunit acetylation and MCP-1 expression in rat mesangial cells
- Abstract PR10: Inhibition of deacetylase SIRT1 offers a novel treatment option in metastatic Ewing sarcoma
- SIRT1 and SIRT2 Gene Expression in Peripheral Blood Mononuclear Cells of Obese Children and Adolescents and their Relationship with Metabolic …
- SIRT1-responsive microRNA-182 contributes to a regulatory loop for recovery of peripheral nerve injury in experimental diabetic neuropathy
- Identification of SIRT1 as a novel regulator of NFAT5 dependent aldose reductase expression under osmatic stress
- Atorvastatin Inhibits High Glucose-induced Oxidative Stress Injury in Human Umbilical Vein Endothelial Cells by SIRT1/NADPH Oxidase Pathway
- THU0471 Myeloid Deletion of SIRT1 Suppresses Collagen-Induced Arthritis in Mice by Modulating Dendritic Cell Function
- PPARalpha/SIRT1 Heterodimer Suppresses Fatty Acid Oxidation Genes in the Heart Under Pressure Overload
- EXOGENOUS SIRT1 INHIBITION OF APOPTOSIS VIA AUTOPHAGY UNDER LOW NUTRITIONAL CONDITION IN HUMAN NUCLEUS PULPOSUS CELLS: GP52.
- SIRT1 Suppresses Self-Renewal of Adult Hippocampal Neural Stem Cells
- Changes in expression of Ac-H3 and SIRT1 in dorsal root ganglions in a rat model of negative phenotype neuropathic pain
- Expression of deacetylase SIRT1 in porcine different developmental stages of follicular granulosa cells.
- Epigallocatechin gallate inhibited proliferation and induced apoptosis of nasopharyngeal carcinoma cells by inhibiting expression of SIRT1
- Resveratrol protects oxygen-glucose deprivation rat cortical neurons by regulating SIRT1/AMPK signaling pathways
- KSY-PH1 Prevents UVB-Induced Damage and Promotes Wound Healing In Skin Cells via Coregulation of SIRT1 and Pin1
- SIRT1 Expression Related with Sarcoma Growth after Stem Cell Transplantation Combined with Depletion of Myeloid-Derived Suppressor Cells
- Abstract T P247: Neuronal SIRT1 Activation Negatively Regulates Rho Kinase in Photothrombotic Stroke
- Insulin Antagonizes SIRT1 and NF‐κB Signaling in Skeletal Muscle of Neonatal Pigs during Chronic Infection
- C108 AGING: THE COMMON DENOMINATOR: SIRT1 eduction Is Involved In Clock Dysfunction, Telomere Attrition, And Inflammosenescence In COPD
- The SIRT1 Activator, SRT1720, Attenuates Cardiac Hypertrophy and Fibrosis in a Rodent Pressure Overload Model
- Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells
- SIRT1-Mediated Inhibition of p66shc Expression Alleviates Liver Ischemia/Reperfusion Injury
- Study on Effect of Buqi-Tongluo-Jiedu Decoction on Protein Concentration of HIC1/SIRT1 of Pancreatic Cancer Model Mice
- SIRT1 regulates the function of the KRAB-associated protein 1 (KAP1) in DNA damage response signaling
- SIRT1 activator SRT3025 provides atheroprotection in ApoE⁻/⁻ mice by increasing hepatic LDL receptor
- SIRT1 Modulates Varicella Zoster Virus Replication in the Rat Dorsal Root Ganglion Neurons
- GW26-e0716 Forestalling SIRT1 Carbonyl Stress by ALDH2 Restores Autophagy in Aged Heart
- Shear Stress-Induced SIRT1 Activation: Effects on Mitochondrial Biogenesis and Endothelial Senescence.
- Protective Effect of Photoreceptor Outer Segments Phagocytosis for Retinal Pigment Epithelial Cells by PGC-1α/SIRT1
- Activation of C/EBPa Myeloid-Specific Transcription Factor By NAMPT/SIRT1-Triggered Deacetylation
- Melatonin improves mitochondrial function by promoting MT1/SIRT1/PGC-1 alpha
- ATGL‐catalyzed lipolysis regulates SIRT1 to control PGC‐1a/PPAR‐a signaling
- Metabolic adaptation of tumor cells under chronic acidosis: role of the SIRT1/HIF2alpha axis to drive reductive glutamine metabolism
- Design and Synthesis of 2-Arylbenzimidazole Analogues as Novel SIRT1 Activators for the Treatment of Type II Diabetes
- Increased p53 Acetylation By SIRT1 Inhibition Is Required for Optimal Activation of p53 Activity and Significantly Enhances the Ability of HDM2 Inhibitors to Target …
- Metabolic adaptation of tumor cells under chronic acidosis: a shift towards reductive glutamine metabolism driven by the SIRT1/HIF2α axis
- C71 THORACIC CANCER: PATHOGENESIS, PREVENTION, AND TREATMENT: Down-Regulated SIRT1 By Non-Steroidal Anti-Inflammatory Drugs Is To Inhibit Tgf …
- Trimetazidine prevents macrophage-mediated septic myocardial dysfunction via SIRT1
- Cardiac SIRT1 Mediates the Cardioprotective Effect of Caloric Restriction by Suppressing Local Complement System Activation after Ischemia/Reperfusion
- ANTI-APOPTOTIC EFFECT OF FERULIC ACID THROUGH MODIFICATION OF SIRT1, SIRT7 AND CASPASE 6 GENE EXPRESSION
- Decreased PGC‐1α‐SIRT1 Signaling Leads to Impaired Angiogenesis in Persistent Pulmonary Hypertension of the Newborn (PPHN)
- GW25-e1534 SIRT1 protects against oxidative stress-induced endothelial progenitor cells apoptosis by inhibiting FOXO3a via FOXO3a ubiquitination and degradation
- α-Mangostin Regulates Hepatic Steatosis and Obesity through SIRT1-AMPK and PPARγ Pathways in High-Fat Diet-Induced Obese Mice
- … IMPROVES INSULIN SENSITIVITY IN HIGH-FAT-DIET-INDUCED INSULIN RESISTANCE RATS VIA ACTIVATION OF SIRT1 AND GLUT4 IN QUADRICEPS …
- NMN, a NAD+ Precursor, Can Rescue Age-associated Susceptibility to Cisplatin-induced Acute Kidney Injury in a SIRT1-dependent Manner
- High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased …
- 1018: SIRT1 ACTIVATORS ALTER TRANSCRIPTIONAL PROFILES OF INFLAMMATORY RESPONSE & IMPROVE OUTCOME IN SEPSIS
- Fast Track: Editor’s choice: The SIRT1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr …
- Low-Dose Deguelin, Selective Targeting of Mt NPM1, Induces Differentiation in NPMc+ AML Cells By Regulation the Axis of SIRT1/CEBPβ/G-CSFR, Instead …
- Correction: Nurr1 Represses Tyrosine Hydroxylase Expression via SIRT1 in Human Neural Stem Cells
- Nicotinic acid synergizes with leucine to stimulate AMPK/SIRT1 signaling and regulates lipid accumulation and lifespan in C. elegans (269.7)
- GW26-e1025 Fenofibrate Prevention of Diabetic Cardiomyopathy Is Mediated by FGF21 Via SIRT1-Dependent Autophagy Modulation
- Liquid fructose downregulates SIRT1 expression and activity and impairs the oxidation of fatty acids in rat and human liver cells
- Regulatory interactions between the metabolic sensors SIRT1 and AMPK in modulating PPARα linked functions, in obesity-dependent type 2 diabetes mellitus
- GW25-e4428 Exogenous Hydrogen Sulfide Delays Nicotinamide-Induced Premature Senescence via SIRT1 pathway in Human Umbilical Vein Endothelial Cells
- SIRT1, SIRT2, SIRT6 and P21 gene expression in the lungs of mice chronically exposed to ambient particulate matter
- … fibrosis and atrial fibrillation in a canine atrial tachycardia model with left ventricular dysfunction: association with p53-microRNA34a-SIRT1 feedback-loop pathway
- Effects of core temperature on exercise-induced mitochondrial biogenesis: Potential role of PGC-1α, AMPK eNOS, SIRT1, and SIRT3
- Transgenic supplementation of SIRT1 fails to alleviate acute loss of nigrostriatal dopamine neurons and gliosis in a mouse model of MPTP-induced …
- Resveratrol stimulation of SIRT1 & exogenous delivery of FGF21 mimics metformin’s ability to alleviate non-alcoholic fatty liver disease caused by diet-induced obesity
- Thematic Poster: TP-30; SIRT1 Contributes to the Pathogenesis of LPS-Induced Lung Injury through the Modulation of PI3K-HIF-VEGF Pathway
- SIRT1 dependent IRS1 phosphorylation mediates the effect of vitamin D on GLUT4 translocation and glucose utilization via PI3K/PTEN/PTP1B/PIP3/AKT/PKCζ/λ …
- PS-1570; Pulmonary Infection: SIRT1 Contributes to the Pathogenesis of LPS-Induced Lung Injury through the Modulation of PI3K-HIF-VEGF Pathway
- Adiponectin suppress T helper 17 differentiation and limits autoimmune CNS inflammation via SIRT1/PPARγ/RORγt singling
- RNA interference of silent mating type information regulation 2 homolog 1 SIRT1 arrests cell cycle progress of prostate cancer PC3 cells
- OP-144 Attenuated SIRT1 Expression Correlates with Enhanced Oxidative Stress in Compensated and Decompensated Heart Failure
- Arginase 1 regulates SIRT1 activity and endothelial senescence in diabetes (1051.1)
- 7: Increased SIRT1 Positive Lymphocytes in Acute Cellular Cardiac Allograft Rejection: Contributor to Pathogenesis and a Therapeutic Target
- Abstract LB-167: The role of SIRT1 in tumorigenesis
- Calycosin Promotes Apoptosis of Breast Cancer Cells MCF-7 through Inhibiting SIRT1
- HO‐1 Induction Attenuates Fructose Mediated Non‐alcoholic Fatty Liver in Hepatocytes and Obese Mice: Involves SIRT1
- Free Paper Presentation: F-141; Mitochondrial ROS Induces Up-regulation of SIRT1 in LPS-Induced Acute Lung Injury
- Slide Session: OS-115; Pulmonary Infection: The Interplay Between Mitochondrial ROS and SIRT1 in LPS-Induced Lung Injury of Mice
- Free Paper Presentation: OS-115; The Interplay Between Mitochondrial ROS and SIRT1 in LPS-Induced Lung Injury of Mice
- Role of silent information regulator 1 (SIRT1) in the malignant biological behavior of prostate cancer
- The Korean Academy of Tuberculosis and Respiratory Diseases: Slide Session; OS-066: Lung Cancer; Down-Regulated SIRT1 by Non-Steroidal Anti-Infl ammatory …
- Free Paper Presentation: OS-66; Down-Regulated SIRT1 by Non-Steroidal Anti-Inflammatory Drugs Is to Inhibit TGF-β1-Induced Epithelial-Mesenchymal Transition …
- 1, 25 dihydroxyvitamin D3 protects the heart against pressure overload-induced hypertrophy without affecting SIRT1 mRNA level
- #VALUE!
- Expression of silence information regulator 1 (SIRT1) in B cells in peripheral venous blood of subacute cutaneous lupus erythematosus
- Homology modeling, Molecular Dynamic Simulation and in silico screening of Activator for the Intensification of human sirtuin type 1 (SIRT1) by novel 1, 3, 4 …
- Endothelial LOX-1 Protects Against Arterial Thrombosis via Activation of the Oct-1/SIRT1 Pathway
- GW26-e2385 Tetrahydroxystilbene Involve HSP-70 and SIRT1 in Preventing the Progression of Diabetic Cardiomyopathy
- … Receptor 2 improves therapeutic efficacy of Adipose-Derived Mesenchymal Stem Cells to alleviate myocardial ischemia injury through AMPK/SIRT1 and TLR4/NF-κB …
- 3, 5, 4 [variant prime]-Tri-O-acetylresveratrol Attenuates Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome via MAPK/SIRT1 Pathway
- Taurine attenuates amyloid β 1â 42-induced mitochondrial dysfunction by activating of SIRT1 in SK-N-SH cells
- Effects of metformin on SIRT1, Nrf2 and AhR expression in cancer cells
- SIRT1 and the mitochondria
- SIRT1 and insulin resistance
- Emerging roles of SIRT1 in fatty liver diseases
- The role of SIRT1 in epileptogenesis
- SIRT1 inhibits oxidative stress in vascular endothelial cells
- Regulation of SIRT1 in aging: roles in mitochondrial function and biogenesis
- The role of SIRT1 in diabetic cardiomyopathy
- SIRT1: role under the condition of ischemia/hypoxia
- How much successful are the medicinal chemists in modulation of SIRT1: A critical review
- Obesity weighs down memory through a mechanism involving the neuroepigenetic dysregulation of SIRT1
- The protective role of SIRT1 in vascular tissue: its relationship to vascular aging and atherosclerosis
- SIRT1, 2, 3 protect mouse oocytes from postovulatory aging
- SIRT1 regulates macrophage self‐renewal
- Spatial dynamics of SIRT1 and the subnuclear distribution of NADH species
- Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells
- LncRNA HULC triggers autophagy via stabilizing SIRT1 and attenuates the chemosensitivity of HCC cells
- SIRT1 mediates depression-like behaviors in the nucleus accumbens
- The prognostic role of SIRT1 expression in solid malignancies: a meta-analysis
- Down-Regulation of SIRT1 Gene Expression in Major Depressive Disorder
- SIRT1 as a therapeutic target for Alzheimer’s disease
- SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis
- Negative regulation of NLRP3 inflammasome by SIRT1 in vascular endothelial cells
- Negative reciprocal regulation between SIRT1 and Per2 modulates the circadian clock and aging
- SIRT1 inhibition causes oxidative stress and inflammation in patients with coronary artery disease
- SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson’s disease
- SIRT1 regulates DNA methylation and differentiation potential of embryonic stem cells by antagonizing Dnmt3l
- SIRT1 regulates canonical TGF-β signalling to control fibroblast activation and tissue fibrosis
- Association between SIRT1 gene polymorphisms and breast cancer in Egyptians
- SIRT1 enhances the survival of human embryonic stem cells by promoting DNA repair
- Histone deacetylase SIRT1 negatively regulates the differentiation of interleukin-9-producing CD4+ T cells
- SIRT1 promotes epithelial–mesenchymal transition and metastasis in colorectal cancer by regulating Fra-1 expression
- Effect of exercise training on skeletal muscle SIRT1 and PGC-1α expression levels in rats of different age
- Aquatide activation of SIRT1 reduces cellular senescence through a SIRT1-FOXO1-autophagy axis
- SIRT1 is required for resveratrol-mediated chemopreventive effects in colorectal cancer cells
- SIRT1 regulates acrosome biogenesis by modulating autophagic flux during spermiogenesis in mice
- SIRT1 activation by resveratrol alleviates cardiac dysfunction via mitochondrial regulation in diabetic cardiomyopathy mice
- SIRT1 inhibits the catabolic effect of IL-1β through TLR2/SIRT1/NF-κB pathway in human degenerative nucleus pulposus cells
- Overexpression of SIRT1 is associated with poor outcomes in patients with ovarian carcinoma
- SIRT1 improves VSMC functions in atherosclerosis
- The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction
- SIRT1 mediates Sphk1/S1P-induced proliferation and migration of endothelial cells
- SIRT1 inhibits inflammatory response partly through regulation of NLRP3 inflammasome in vascular endothelial cells
- O-GlcNAcylation of SIRT1 enhances its deacetylase activity and promotes cytoprotection under stress
- Specific SIRT1 activator-mediated improvement in glucose homeostasis requires SIRT1-independent activation of AMPK
- SIRT1/3 activation by resveratrol attenuates acute kidney injury in a septic rat model
- QSAR differential model for prediction of SIRT1 modulation using Monte Carlo method
- SIRT1 protects the heart from ER stress-induced cell death through eIF2 α deacetylation
- Resveratrol serves as a protein-substrate interaction stabilizer in human SIRT1 activation
- Sirt7 promotes adipogenesis in the mouse by inhibiting autocatalytic activation of SIRT1
- mTORC1 and SIRT1 cooperate to foster expansion of gut adult stem cells during calorie restriction
- SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2
- Mitochondria elongation is mediated through SIRT1-mediated MFN1 stabilization
- CLOCK and BMAL1 regulate muscle insulin sensitivity via SIRT1 in male mice
- ATGL promotes autophagy/lipophagy via SIRT1 to control hepatic lipid droplet catabolism
- SIRT1 AS lncRNA interacts with its mRNA to inhibit muscle formation by attenuating function of miR-34a
- Activation and overexpression of SIRT1 attenuates lung fibrosis via P300
- Novel osmotin inhibits SREBP2 via the AdipoR1/AMPK/SIRT1 pathway to improve Alzheimer’s disease neuropathological deficits
- Quercetin improves glucose and lipid metabolism of diabetic rats: involvement of Akt signaling and SIRT1
- Regulation and function of SIRT1 in rheumatoid arthritis synovial fibroblasts
- Curcumin protects against myocardial infarction-induced cardiac fibrosis via SIRT1 activation in vivo and in vitro
- SIRT1 overexpression in mouse hippocampus induces cognitive enhancement through proteostatic and neurotrophic mechanisms
- Epidermal SIRT1 regulates inflammation, cell migration, and wound healing
- Evidence for possible role of melatonin in reducing oxidative stress in multiple sclerosis through its effect on SIRT1 and antioxidant enzymes
- Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1, and eNOS
- Mir-29b regulates oxidative stress by targeting SIRT1 in ovarian cancer cells
- SIRT1-PGC1α-NFκB Pathway of Oxidative and Inflammatory Stress during Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving …
- Protective effects of SIRT1 in patients with proliferative diabetic retinopathy via the inhibition of IL-17 expression
- SIRT1 attenuates neuropathic pain by epigenetic regulation of mGluR1/5 expressions in type 2 diabetic rats
- Curcumin pretreatment attenuates inflammation and mitochondrial dysfunction in experimental stroke: The possible role of SIRT1 signaling
- SIRT1 inhibition promotes atherosclerosis through impaired autophagy
- SUV39H1 mediated SIRT1 trans-repression contributes to cardiac ischemia–reperfusion injury
- SIRT1 promotes metastasis of human osteosarcoma cells
- SIRT1 activates the expression of fetal hemoglobin genes
- SIRT1 and neural cell fate determination
- SIRT1 regulates the chemoresistance and invasiveness of ovarian carcinoma cells
- Celastrol ameliorates liver metabolic damage caused by a high-fat diet through SIRT1
- SIRT1‐mediated transcriptional regulation of SOX2 is important for self‐renewal of liver cancer stem cells
- The anti-ageing molecule SIRT1 mediates beneficial effects of cardiac rehabilitation
- Hepatic stellate cell-specific deletion of SIRT1 exacerbates liver fibrosis in mice
- The NAD+/PARP1/SIRT1 axis in aging
- Resveratrol alleviates cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasome activation through SIRT1-dependent autophagy induction
- SIRT1 activation attenuates diastolic dysfunction by reducing cardiac fibrosis in a model of anthracycline cardiomyopathy
- Modulation of mitochondrial membrane potential and ROS generation by nicotinamide in a manner independent of SIRT1 and mitophagy
- SIRT1 carboxyl-domain is an ATP-repressible domain that is transferrable to other proteins
- Clock Gene Bmal1 Modulates Human Cartilage Gene Expression by Crosstalk With SIRT1
- Resveratrol supplement inhibited the NF-κB inflammation pathway through activating AMPKα-SIRT1 pathway in mice with fatty liver
- O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway
- HIPK2 restricts SIRT1 activity upon severe DNA damage by a phosphorylation-controlled mechanism
- Expression and clinical significance of SIRT1 in colorectal cancer
- SIRT1 suppresses colorectal cancer metastasis by transcriptional repression of miR-15b-5p
- Berberine suppresses LPS-induced inflammation through modulating SIRT1/NF-κB signaling pathway in RAW264. 7 cells
- SIRT1 suppresses adipogenesis by activating Wnt/β-catenin signaling in vivo and in vitro
- SIRT1 plays a neuroprotective role in traumatic brain injury in rats via inhibiting the p38 MAPK pathway
- Reduction in podocyte SIRT1 accelerates kidney injury in aging mice
- The effect of hesperidin and quercetin on oxidative stress, NF-κB and SIRT1 levels in a STZ-induced experimental diabetes model
- SIRT1 was involved in TNF-α-promoted osteogenic differentiation of human DPSCs through Wnt/β-catenin signal
- Haploinsufficiency of SIRT1 enhances glutamine metabolism and promotes cancer development
- SIRT1 protects endothelial cells against LPS-induced barrier dysfunction
- Role of SIRT1 plays in nucleus pulposus cells and intervertebral disc degeneration
- Melatonin prevents acute kidney injury in severely burned rats via the activation of SIRT1
- Sirtuin1 (SIRT1) in the acetylation of downstream target proteins
- SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1α-mediated mitochondrial biogenesis
- Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway
- Moving to the rhythm with clock (circadian) genes, autophagy, mTOR, and SIRT1 in degenerative disease and cancer
- Resveratrol protects against spinal cord injury by activating autophagy and inhibiting apoptosis mediated by the SIRT1/AMPK signaling pathway
- Role of SIRT1/PGC-1α in mitochondrial oxidative stress in autistic spectrum disorder
- Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription
- Arctigenin attenuates ischemic stroke via SIRT1-dependent inhibition of NLRP3 inflammasome
- Resveratrol inhibits proliferation and migration through SIRT1 mediated post‑translational modification of PI3K/AKT signaling in hepatocellular carcinoma …
- MicroRNA-133b inhibits hepatocellular carcinoma cell progression by targeting SIRT1
- Blocking SIRT1 inhibits cell proliferation and promotes aging through the PI3K/AKT pathway
- SIRT1 in endothelial cells as a novel target for the prevention of early vascular aging
- Cardioprotective effects of fibroblast growth factor 21 against doxorubicin-induced toxicity via the SIRT1/LKB1/AMPK pathway
- SIRT1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury
- Vitamin D decreases adipocyte lipid storage and increases NAD-SIRT1 pathway in 3T3-L1 adipocytes
- Resveratrol and caloric restriction prevent hepatic steatosis by regulating SIRT1-autophagy pathway and alleviating endoplasmic reticulum stress in high-fat …
- SIRT1 limits adipocyte hyperplasia through c-Myc inhibition
- The SIRT1 activator, SRT1720, attenuates renal fibrosis by inhibiting CTGF and oxidative stress
- BRCA1 inhibits AR–mediated proliferation of breast cancer cells through the activation of SIRT1
- Interactions between SIRT1 and MAPKs regulate astrocyte activation induced by brain injury in vitro and in vivo
- Screening SIRT1 activators from medicinal plants as bioactive compounds against oxidative damage in mitochondrial function
- Resveratrol provides neuroprotection by inhibiting phosphodiesterases and regulating the cAMP/AMPK/SIRT1 pathway after stroke in rats
- The sirtuin family members SIRT1, SIRT3 and SIRT6: Their role in vascular biology and atherogenesis
- Clinicopathological significance of SIRT1 expression in colorectal cancer: A systematic review and meta analysis
- SIRT1 is essential for resveratrol enhancement of hypoxia-induced autophagy in the type 2 diabetic nephropathy rat
- Neuronal SIRT1 (silent information regulator 2 homologue 1) regulates glycolysis and mediates resveratrol-induced ischemic tolerance
- Resveratrol alleviates MPTP‐induced motor impairments and pathological changes by autophagic degradation of α‐synuclein via SIRT1‐deacetylated LC3
- Methyl-deficient diet promotes colitis and SIRT1-mediated endoplasmic reticulum stress
- SIRT1 may play a crucial role in overload‐induced hypertrophy of skeletal muscle
- miR-23b-3p induces the cellular metabolic memory of high glucose in diabetic retinopathy through a SIRT1-dependent signalling pathway
- Cellular localization of NRF2 determines the self-renewal and osteogenic differentiation potential of human MSCs via the P53–SIRT1 axis
- SIRT1 polymorphisms and serum-induced SIRT1 protein expression in aging and frailty: the CHAMP study
- The SIRT1 inhibitor EX-527 suppresses mTOR activation and alleviates acute lung injury in mice with endotoxiemia
- Use of the Monte Carlo Method for OECD Principles‐Guided QSAR Modeling of SIRT1 Inhibitors
- Akt2 ablation prolongs life span and improves myocardial contractile function with adaptive cardiac remodeling: Role of SIRT1‐mediated autophagy regulation
- Salmonella Typhimurium disrupts SIRT1/AMPK checkpoint control of mTOR to impair autophagy
- Harnessing the power of SIRT1 and non-coding RNAs in vascular disease
- The epigenetic regulation of HIF-1α by SIRT1 in MPP+ treated SH-SY5Y cells
- SIRT1 exerts protective effects against paraquat-induced injury in mouse type II alveolar epithelial cells by deacetylating NRF2 in vitro
- Dual SIRT1 expression patterns strongly suggests its bivalent role in human breast cancer
- AMPK and SIRT1 activation contribute to inhibition of neuroinflammation by thymoquinone in BV2 microglia
- The effect of lead exposure on expression of SIRT1 in the rat hippocampus
- SIRT1-mediated FoxOs pathways protect against apoptosis by promoting autophagy in osteoblast-like MC3T3-E1 cells exposed to sodium fluoride
- Nrf2/antioxidant defense pathway is involved in the neuroprotective effects of SIRT1 against focal cerebral ischemia in rats after hyperbaric oxygen preconditioning
- Activation of SIRT1 Attenuates Klotho Deficiency–Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity
- SIRT1 as a potential biomarker of response to treatment with glatiramer acetate in multiple sclerosis
- KRAS activation and over-expression of SIRT1/BCL6 contributes to the pathogenesis of endometriosis and progesterone resistance
- miR-34a-5p Inhibition Alleviates Intestinal Ischemia/Reperfusion-Induced Reactive Oxygen Species Accumulation and Apoptosis via Activation of SIRT1 Signaling
- Resveratrol enhances autophagic flux and promotes Ox-LDL degradation in HUVECs via upregulation of SIRT1
- MicroRNA-34a affects chondrocyte apoptosis and proliferation by targeting the SIRT1/p53 signaling pathway during the pathogenesis of osteoarthritis
- Circulating SIRT1 increases after intragastric balloon fat loss in obese patients
- SIRT1‐mediated ERβ suppression in the endothelium contributes to vascular aging
- LncRNA‑mediated SIRT1/FoxO3a and SIRT1/p53 signaling pathways regulate type II alveolar epithelial cell senescence in patients with chronic obstructive …
- SIRT1 promotes the proliferation and metastasis of human pancreatic cancer cells
- Regulation of SIRT1/Nrf2/TNF-α signaling pathway by luteolin is critical to attenuate acute mercuric chloride exposure induced hepatotoxicity
- Galangin induces autophagy via deacetylation of LC3 by SIRT1 in HepG2 cells
- Role of nutraceutical SIRT1 modulators in AMPK and mTOR pathway: Evidence of a synergistic effect
- Protective effects of resveratrol on osteoporosis via activation of the SIRT1‑NF‑κB signaling pathway in rats
- An agonist of the protective factor SIRT1 improves functional recovery and promotes neuronal survival by attenuating inflammation after spinal cord injury
- SIRT1 inhibits differentiation of monocytes to macrophages: amelioration of synovial inflammation in rheumatoid arthritis
- Isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by SIRT1 activation in experimental diabetic neuropathy
- Resveratrol ameliorates hyperglycemia-induced renal tubular oxidative stress damage via modulating the SIRT1/FOXO3a pathway
- SIRT1 ameliorates systemic sclerosis by targeting the mTOR pathway
- NAMPT regulates senescence, proliferation, and migration of endothelial progenitor cells through the SIRT1 AS lncRNA/miR-22/SIRT1 pathway
- Histone deacetylase SIRT1 controls proliferation, circadian rhythm, and lipid metabolism during liver regeneration in mice
- SIRT1 and AMPK pathways are essential for the proliferation and survival of primary effusion lymphoma cells
- CKII-SIRT1-SM22α loop evokes a self-limited inflammatory response in vascular smooth muscle cells
- Epigenetic regulation through SIRT1 in podocytes
- The effect of exercise, resveratrol or their combination on Sarcopenia in aged rats via regulation of AMPK/SIRT1 pathway
- SIRT1 disruption in human fetal hepatocytes leads to increased accumulation of glucose and lipids
- Activation of the miR-34a/SIRT1/p53 Signaling Pathway Contributes to the Progress of Liver Fibrosis via Inducing Apoptosis in Hepatocytes but Not in HSCs
- Ginsenoside Rb2 alleviates hepatic lipid accumulation by restoring autophagy via induction of SIRT1 and activation of AMPK
- Association of SIRT1 and HMGA1 expression in non-small cell lung cancer
- Fenofibrate increases cardiac autophagy via FGF21/SIRT1 and prevents fibrosis and inflammation in the hearts of Type 1 diabetic mice
- Magnolol attenuates the inflammation and apoptosis through the activation of SIRT1 in experimental stroke rats
- Inflammation downregulates UCP1 expression in brown adipocytes potentially via SIRT1 and DBC1 interaction
- LEF1‐mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes
- SIRT1 regulates Mxd1 during malignant melanoma progression
- Weight Loss Is Associated With Increased NAD+/SIRT1 Expression But Reduced PARP Activity in White Adipose Tissue
- Melatonin facilitates adipose‐derived mesenchymal stem cells to repair the murine infarcted heart via the SIRT1 signaling pathway
- The prognostic role of SIRT1-autophagy axis in gastric cancer
- Overexpression of SIRT1 prevents hypoxia‑induced apoptosis in osteoblast cells
- SIRT1 induces resistance to apoptosis in human granulosa cells by activating the ERK pathway and inhibiting NF-κB signaling with anti-inflammatory functions
- Silibinin restores NAD+ levels and induces the SIRT1/AMPK pathway in non-alcoholic fatty liver
- Lysophosphatidic acid promotes epithelial to mesenchymal transition in ovarian cancer cells by repressing SIRT1
- Erythropoietin activates SIRT1 to protect human cardiomyocytes against doxorubicin-induced mitochondrial dysfunction and toxicity
- SIRT1 regulates cognitive performance and ability of learning and memory in diabetic and nondiabetic models
- MiR-181b regulates steatosis in nonalcoholic fatty liver disease via targeting SIRT1
- SIRT1: a novel target for the treatment of muscular dystrophies
- SIRT1/Atg5/autophagy are involved in the antiatherosclerosis effects of ursolic acid
- Resveratrol protects mice from paraquat-induced lung injury: The important role of SIRT1 and NRF2 antioxidant pathways
- Restoration of SIRT1 function by pterostilbene attenuates hypoxia-reoxygenation injury in cardiomyocytes
- miR-181a increases FoxO1 acetylation and promotes granulosa cell apoptosis via SIRT1 downregulation
- SIRT1/HSF1/HSP pathway is essential for exenatide‐alleviated, lipid‐induced hepatic endoplasmic reticulum stress
- Activation of miR-34a-5p/SIRT1/p66shc pathway contributes to doxorubicin-induced cardiotoxicity
- A CREB-SIRT1-Hes1 circuitry mediates neural stem cell response to glucose availability
- The crosstalk between SIRT1 and Keap1/Nrf2/ARE anti-oxidative pathway forms a positive feedback loop to inhibit FN and TGF-β1 expressions in rat glomerular …
- Betulin alleviated ethanol-induced alcoholic liver injury via SIRT1/AMPK signaling pathway
- IRF8 is the target of SIRT1 for the inflammation response in macrophages
- SIRT1/adenosine monophosphate-activated protein kinase α signaling enhances macrophage polarization to an anti-inflammatory phenotype in rheumatoid …
- SIRT1 gain of function does not mimic or enhance the adaptations to intermittent fasting
- From the Cover: l-Carnitine via PPARγ- and SIRT1-Dependent Mechanisms Attenuates Epithelial-Mesenchymal Transition and Renal Fibrosis Caused by …
- Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α
- SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model
- SIRT1 regulates the inflammatory response of vascular adventitial fibroblasts through autophagy and related signaling pathway
- miR-200a controls hepatic stellate cell activation and fibrosis via SIRT1/Notch1 signal pathway
- SIRT1 and NAD+ precursors: Therapeutic targets in multiple sclerosis a review
- SIRT1 functions as a negative regulator of eukaryotic poly (A) RNA transport
- SIRT1 and SIRT7 expression in adipose tissues of obese and normal-weight individuals is regulated by microRNAs but not by methylation status
- Vitamin D insufficiency exacerbates adipose tissue macrophage infiltration and decreases AMPK/SIRT1 activity in obese rats
- Estrogen modulates vascular smooth muscle cell function through downregulation of SIRT1
- SIRT1 and Parp1 as epigenome safeguards and microRNAs as SASP-associated signals, in cellular senescence and aging
- The metal nanoparticle-induced inflammatory response is regulated by SIRT1 through NF-κB deacetylation in aseptic loosening
- Meta-analysis of SIRT1 expression as a prognostic marker for overall survival in gastrointestinal cancer
- Dioscin alleviates BDL-and DMN-induced hepatic fibrosis via SIRT1/Nrf2-mediated inhibition of p38 MAPK pathway
- Fisetin inhibits IL-1β-induced inflammatory response in human osteoarthritis chondrocytes through activating SIRT1 and attenuates the progression of osteoarthritis in …
- SIRT1 deacetylates the cardiac transcription factor Nkx2. 5 and inhibits its transcriptional activity
- Cilostazol modulates autophagic degradation of β-amyloid peptide via SIRT1-coupled LKB1/AMPKα signaling in neuronal cells
- Suppression of SIRT1 sensitizes lung cancer cells to WEE1 inhibitor MK-1775-induced DNA damage and apoptosis
- Berberine protects against ischemia/reperfusion injury after orthotopic liver transplantation via activating SIRT1/FoxO3α induced autophagy
- Forkhead transcription factor FOXO1 inhibits angiogenesis in gastric cancer in relation to SIRT1
- Co-ordinated overexpression of SIRT1 and STAT3 is associated with poor survival outcome in gastric cancer patients
- USP22 mediates the multidrug resistance of hepatocellular carcinoma via the SIRT1/AKT/MRP1 signaling pathway
- Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: involvement of SIRT1 and SIRT6
- Downregulation of miR-199b is associated with distant metastasis in colorectal cancer via activation of SIRT1 and inhibition of CREB/KISS1 signaling
- Resveratrol prevents ROS-induced apoptosis in high glucose-treated retinal capillary endothelial cells via the activation of AMPK/SIRT1/PGC-1α pathway
- CD38 deficiency protects the heart from ischemia/reperfusion injury through activating SIRT1/FOXOs-mediated antioxidative stress pathway
- Vitamin D protects endothelial cells from irradiation-induced senescence and apoptosis by modulating MAPK/SIRT1 axis
- Hydrogen sulfide attenuates chronic restrain stress-induced cognitive impairment by upreglulation of SIRT1 in hippocampus
- Reducing Smad3/ATF4 was essential for SIRT1 inhibiting ER stress-induced apoptosis in mice brown adipose tissue
- The expression of SIRT1 in articular cartilage of patients with knee osteoarthritis and its correlation with disease severity
- Salidroside ameliorates sepsis-induced acute lung injury and mortality via downregulating NF-κB and HMGB1 pathways through the upregulation of SIRT1
- SIRT1 rs10823108 and FOXO1 rs17446614 responsible for genetic susceptibility to diabetic nephropathy
- SIRT1 activation inhibits hyperglycemia-induced apoptosis by reducing oxidative stress and mitochondrial dysfunction in human endothelial cells
- SIRT1‐SIRT3 Axis Regulates Cellular Response to Oxidative Stress and Etoposide
- Vitamin D supplementation inhibits oxidative stress and upregulate SIRT1/AMPK/GLUT4 cascade in high glucose-treated 3T3L1 adipocytes and in adipose tissue of …
- Up-regulation of SIRT1 reduces endoplasmic reticulum stress and renal fibrosis
- Resveratrol ameliorates palmitate‐induced inflammation in skeletal muscle cells by attenuating oxidative stress and JNK/NF‐κB pathway in a SIRT1‐independent …
- Downregulation of SIRT1 signaling underlies hepatic autophagy impairment in glycogen storage disease type Ia
- Regulatory effects of the AMPKα-SIRT1 molecular pathway on insulin resistance in PCOS mice: an in vitro and in vivo study
- Effect of genistein on expression of pancreatic SIRT1, inflammatory cytokines and histological changes in ovariectomized diabetic rat
- Carnosic acid alleviates chronic alcoholic liver injury by regulating the SIRT1/ChREBP and SIRT1/p66shc pathways in rats
- SIRT1 activation by pterostilbene attenuates the skeletal muscle oxidative stress injury and mitochondrial dysfunction induced by ischemia reperfusion injury
- Activation of SIRT1/FXR signaling pathway attenuates triptolide-induced hepatotoxicity in rats
- SIRT1 protects cardiac cells against apoptosis induced by zearalenone or its metabolites α-and β-zearalenol through an autophagy-dependent pathway
- SIRT1 protects human lens epithelial cells against oxidative stress by inhibiting p53-dependent apoptosis
- The neuroprotective effects of SIRT1 on NMDA-induced excitotoxicity
- Macrophage heme oxygenase-1-SIRT1-p53 axis regulates sterile inflammation in liver ischemia-reperfusion injury
- miR-133b inhibits glioma cell proliferation and invasion by targeting SIRT1
- P66 Shc-SIRT1 Regulation of Oxidative Stress Protects Against Cardio-cerebral Vascular Disease
- SIRT1 enzymatically potentiates 1, 25-dihydroxyvitamin D3 signaling via vitamin D receptor deacetylation
- iNOS as a driver of inflammation and apoptosis in mouse skeletal muscle after burn injury: possible involvement of SIRT1 S-nitrosylation-mediated acetylation …
- Polydatin protecting kidneys against hemorrhagic shock-induced mitochondrial dysfunction via SIRT1 activation and p53 deacetylation
- miR-200a-3p promotes β-Amyloid-induced neuronal apoptosis through down-regulation of SIRT1 in Alzheimer’s disease
- Exendin-4 upregulates adiponectin level in adipocytes via SIRT1/Foxo-1 signaling pathway
- … glucagon like peptide 1 analogue, exendin-4, attenuates oxidative stress-induced retinal cell death in early diabetic rats through promoting SIRT1 and Sirt3 expression
- SIRT1-activating compounds (STAC) negatively regulate pancreatic cancer cell growth and viability through a SIRT1 lysosomal-dependent pathway
- SIRT1 protects osteoblasts against particle-induced inflammatory responses and apoptosis in aseptic prosthesis loosening
- Lycium barbarum polysaccharide attenuates high-fat diet-induced hepatic steatosis by up-regulating SIRT1 expression and deacetylase activity
- LncRNA H19 promotes the differentiation of bovine skeletal muscle satellite cells by suppressing SIRT1/FoxO1
- SIRT1 expression is associated with CD31 expression in blood cells from patients with chronic obstructive pulmonary disease
- SIRT1 decreased adipose inflammation by interacting with Akt2 and inhibiting mTOR/S6K1 pathway in mice [S]
- Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating SIRT1/AMPKα/SREBP1 signaling pathway
- SIRT1 activator ameliorates the renal tubular injury induced by hyperglycemia in vivo and in vitro via inhibiting apoptosis
- Repressed SIRT1/PGC-1α pathway and mitochondrial disintegration in iPSC-derived RPE disease model of age-related macular degeneration
- Long non-coding RNA HNF1A-AS1 mediated repression of miR-34a/SIRT1/p53 feedback loop promotes the metastatic progression of colon cancer by functioning as …
- Early-life exposure to lead induces cognitive impairment in elder mice targeting SIRT1 phosphorylation and oxidative alterations
- Genistein ameliorates ischemia/reperfusion-induced renal injury in a SIRT1-dependent manner
- The NAMPT/E2F2/SIRT1 axis promotes proliferation and inhibits p53-dependent apoptosis in human melanoma cells
- Melatonin protects premature ovarian insufficiency induced by tripterygium glycosides: role of SIRT1
- Salvianolic acid B protects against chronic alcoholic liver injury via SIRT1-mediated inhibition of CRP and ChREBP in rats
- Salidroside attenuates ventilation induced lung injury via SIRT1-dependent inhibition of NLRP3 inflammasome
- Rutin protects rat articular chondrocytes against oxidative stress induced by hydrogen peroxide through SIRT1 activation
- Mesenchymal stem cell-conditioned media ameliorate diabetic endothelial dysfunction by improving mitochondrial bioenergetics via the SIRT1/AMPK/PGC-1α pathway
- The deacetylase SIRT1 regulates the replication properties of human papillomavirus 16 E1 and E2
- Suppression of miR-34a expression in the myocardium protects against ischemia–reperfusion injury through SIRT1 protective pathway
- Impaired SIRT1 promotes the migration of vascular smooth muscle cell-derived foam cells
- Mir‐217 promotes inflammation and fibrosis in high glucose cultured rat glomerular mesangial cells via SIRT1/HIF‐1α signaling pathway
- A novel SIRT1 inhibitor, 4bb induces apoptosis in HCT116 human colon carcinoma cells partially by activating p53
- Combination treatment with quercetin and resveratrol attenuates high fat diet‑induced obesity and associated inflammation in rats via the AMPKα1/SIRT1 …
- Rhapontin ameliorates colonic epithelial dysfunction in experimental colitis through SIRT1 signaling
- Effect of the BRCA1-SIRT1-EGFR axis on cisplatin sensitivity in ovarian cancer
- Tucum-do-Cerrado (Bactris setosa Mart.) may promote anti-aging effect by upregulating SIRT1-Nrf2 pathway and attenuating oxidative stress and inflammation
- Oncogenic role of SIRT1 associated with tumor invasion, lymph node metastasis, and poor disease-free survival in triple negative breast cancer
- Protective effect of trans-δ-viniferin against high glucose-induced oxidative stress in human umbilical vein endothelial cells through the SIRT1 pathway
- Ampelopsin attenuates brain aging of D-gal-induced rats through miR-34a-mediated SIRT1/mTOR signal pathway
- SIRT1 regulates apoptosis and extracellular matrix degradation in resveratrol‑treated osteoarthritis chondrocytes via the Wnt/β‑catenin signaling pathways
- Pyrroloquinoline Quinone, a Redox-Active o-Quinone, Stimulates Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α Signaling Pathway
- Effects of BMAL1–SIRT1-positive cycle on estrogen synthesis in human ovarian granulosa cells: an implicative role of BMAL1 in PCOS
- Inhibition of microRNA-449a prevents IL-1β-induced cartilage destruction via SIRT1
- SIRT1 activator represses the transcription of TNF‑α in THP‑1 cells of a sepsis model via deacetylation of H4K16
- Design, synthesis of allosteric peptide activator for human SIRT1 and its biological evaluation in cellular model of Alzheimer’s disease
- Mechanism of SIRT1 NAD+-dependent protein deacetylase inhibition by cysteine S-nitrosation
- Sir2/SIRT1 links acute inebriation to presynaptic changes and the development of alcohol tolerance, preference, and reward
- Lipopolysaccharide modulates p300 and SIRT1 to promote PRMT1 stability via an SCFFbxl17-recognized acetyldegron
- Pharmacological SIRT1 activation improves mortality and markedly alters transcriptional profiles that accompany experimental sepsis
- Upregulated miR‐132 in Lgr5+ gastric cancer stem cell‐like cells contributes to cisplatin‐resistance via SIRT1/CREB/ABCG2 signaling pathway
- TIM4-TIM1 interaction modulates Th2 pattern inflammation through enhancing SIRT1 expression
- Tremella fuciformis polysaccharide suppresses hydrogen peroxide-triggered injury of human skin fibroblasts via upregulation of SIRT1
- Association between functional SIRT1 polymorphisms and the clinical characteristics of patients with autoimmune thyroid disease
- Ablation of systemic SIRT1 activity promotes nonalcoholic fatty liver disease by affecting liver-mesenteric adipose tissue fatty acid mobilization
- Shikonin induces apoptosis of lung cancer cells via activation of FOXO3a/EGR1/SIRT1 signaling antagonized by p300
- Nicotinamide protects hepatocytes against palmitate-induced lipotoxicity via SIRT1-dependent autophagy induction
- Polydatin inhibits the oxidative stress-induced proliferation of vascular smooth muscle cells by activating the eNOS/SIRT1 pathway
- Astaxanthin attenuated pressure overload-induced cardiac dysfunction and myocardial fibrosis: Partially by activating SIRT1
- SIRT1 deficiency protects cochlear cells and delays the early onset of age-related hearing loss in C57BL/6 mice
- The SIRT1 inhibitor, nicotinamide, inhibits hepatitis B virus replication in vitro and in vivo
- Resveratrol attenuates triglyceride accumulation associated with upregulation of SIRT1 and lipoprotein lipase in 3T3-L1 adipocytes
- Inactivation of SIRT1 in mouse livers protects against endotoxemic liver injury by acetylating and activating NF-κ B
- Dietary proanthocyanidins boost hepatic NAD+ metabolism and SIRT1 expression and activity in a dose-dependent manner in healthy rats
- A study of SIRT1 regulation and the effect of resveratrol on synoviocyte invasion and associated joint destruction in rheumatoid arthritis
- SIRT1 and LSD1 competitively regulate KU70 functions in DNA repair and mutation acquisition in cancer cells
- Pterostilbene alleviates polymicrobial sepsis-induced liver injury: possible role of SIRT1 signaling
- Capsaicin inhibits multiple bladder cancer cell phenotypes by inhibiting tumor-associated NADH oxidase (tNOX) and sirtuin1 (SIRT1)
- Obesity-linked phosphorylation of SIRT1 by casein kinase 2 inhibits its nuclear localization and promotes fatty liver
- Activation of the AMPK/SIRT1 pathway by a leucine–metformin combination increases insulin sensitivity in skeletal muscle, and stimulates glucose and lipid metabolism …
- Synthesis and assay of SIRT1-activating compounds
- Hyperbaric Oxygen Reduces Infarction Volume and Hemorrhagic Transformation Through ATP/NAD+/SIRT1 Pathway in Hyperglycemic Middle Cerebral Artery …
- Cardiometabolic effects of a novel SIRT1 activator, SRT2104, in people with type 2 diabetes mellitus
- Upregulation of SIRT1-AMPK by thymoquinone in hepatic stellate cells ameliorates liver injury
- Glycyrrhizic acid prevents diabetic nephropathy by activating AMPK/SIRT1/PGC-1α signaling in db/db mice
- Ethyl pyruvate inhibits the acetylation and release of HMGB1 via effects on SIRT1/STAT signaling in LPS-activated RAW264. 7 cells and peritoneal macrophages
- … ameliorates non‐alcoholic fatty liver disease by enhancing mitochondrial architecture and promoting autophagy through the SIRT1/SIRT3–FOXO3a pathway
- CTRP9 induces mitochondrial biogenesis and protects high glucose-induced endothelial oxidative damage via AdipoR1-SIRT1-PGC-1α activation
- SIRT1 and FOXO1 mRNA expression in PBMC correlates to physical activity in COPD patients
- Prognostic and clinicopathological significance of SIRT1 expression in NSCLC: a meta-analysis
- Myeloid deletion of SIRT1 suppresses collagen-induced arthritis in mice by modulating dendritic cell maturation
- Melatonin attenuates early brain injury via the melatonin receptor/SIRT1/NF-κB signaling pathway following subarachnoid hemorrhage in mice
- Knockdown of SIRT1 suppresses bladder cancer cell proliferation and migration and induces cell cycle arrest and antioxidant response through FOXO3a …
- Plant-derived compounds strigolactone GR24 and pinosylvin activate SIRT1 and enhance glucose uptake in rat skeletal muscle cells
- Short-term starvation attenuates liver ischemia-reperfusion injury (IRI) by SIRT1-autophagy signaling in mice
- Grape seed procyanidin B2 protects podocytes from high glucose-induced mitochondrial dysfunction and apoptosis via the AMPK-SIRT1-PGC-1α axis in vitro
- SIRT1 is required for mitochondrial biogenesis reprogramming in hypoxic human pulmonary arteriolar smooth muscle cells
- Berberine alleviates oxidative stress in islets of diabetic mice by inhibiting miR‐106b expression and up‐regulating SIRT1
- … Receptor Relieves Angiotensin II–Induced Senescence in Vascular Smooth Muscle Cells by Raising Nicotinamide Adenine Dinucleotide–Dependent SIRT1 Activity
- Polydatin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation by inhibiting NF-κB/NLRP3 inflammasome activation via the AMPK/SIRT1 …
- SIRT1 alleviates senescence of degenerative human intervertebral disc cartilage endo-plate cells via the p53/p21 pathway
- The polyphenol oleuropein aglycone modulates the PARP1-SIRT1 interplay: an in vitro and in vivo study
- Transcriptional repression of SIRT1 by protein inhibitor of activated STAT 4 (PIAS4) in hepatic stellate cells contributes to liver fibrosis
- MiR-34a contributes to diabetes-related cochlear hair cell apoptosis via SIRT1/HIF-1α signaling
- MicroRNA-34a induces a senescence-like change via the down-regulation of SIRT1 and up-regulation of p53 protein in human esophageal squamous cancer cells …
- Effect of SIRT1 gene on epithelial-mesenchymal transition of human prostate cancer PC-3 cells
- Short-term ursolic acid promotes skeletal muscle rejuvenation through enhancing of SIRT1 expression and satellite cells proliferation
- Alkylresorcinols activate SIRT1 and delay ageing in Drosophila melanogaster
- FOXQ1 regulates senescence-associated inflammation via activation of SIRT1 expression
- Phosphorylated SIRT1 associates with replication origins to prevent excess replication initiation and preserve genomic stability
- SIRT1 interaction with active Smad2 modulates transforming growth factor-β regulated transcription
- Brown and white adipose tissue expression of IL6, UCP1 and SIRT1 are associated with alterations in clinical, metabolic and anthropometric parameters in obese …
- Olmesartan prevents microalbuminuria in db/db diabetic mice through inhibition of angiotensin II/p38/SIRT1-induced podocyte apoptosis
- SIRT1: a novel guardian of brown fat against metabolic damage
- β2‐AR activation induces chemoresistance by modulating p53 acetylation through upregulating SIRT1 in cervical cancer cells
- Vitamin D receptor deficit induces activation of renin angiotensin system via SIRT1 modulation in podocytes
- SIRT1 negatively regulates FcεRI-mediated mast cell activation through AMPK-and PTP1B-dependent processes
- Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways
- Silencing of HJURP induces dysregulation of cell cycle and ROS metabolism in bladder cancer cells via PPARγ-SIRT1 feedback loop
- SIRT1, a class III histone deacetylase, regulates LPS-induced inflammation in human keratinocytes and mediates the anti-inflammatory effects of hinokitiol
- CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPARγ and inhibit adipogenesis
- The expression of SIRT1 regulates the metastaticplasticity of chondrosarcoma cells by inducing epithelial-mesenchymal transition
- Metformin impairs systemic bile acid homeostasis through regulating SIRT1 protein levels
- … augments ER stress and the cytotoxic effects of glycolytic inhibition in neuroblastoma by downregulating Akt in a mechanism independent of SIRT1
- SIRT1 induces tumor invasion by targeting epithelial mesenchymal transition-related pathway and is a prognostic marker in triple negative breast cancer
- An improved fluorogenic assay for SIRT1, SIRT2, and SIRT3
- Common variants in SIRT1 and human longevity in a Chinese population
- SIRT1 activity is linked to its brain region-specific phosphorylation and is impaired in Huntington’s disease mice
- SIRT1 prevents hyperuricemia via the PGC-1α/PPARγ-ABCG2 pathway
- Cardiac SIRT1 mediates the cardioprotective effect of caloric restriction by suppressing local complement system activation after ischemia-reperfusion
- SIRT1 as a promising novel therapeutic target for myocardial ischemia reperfusion injury and cardiometabolic disease
- Ginkgetin aglycone ameliorates LPS-induced acute kidney injury by activating SIRT1 via inhibiting the NF-κB signaling pathway
- Prognostic and clinicopathologic significance of SIRT1 expression in hepatocellular carcinoma
- Resveratrol promotes human embryonic stem cells self-renewal by targeting SIRT1-ERK signaling pathway
- Resveratrol ameliorates contrast induced nephropathy through the activation of SIRT1-PGC-1α-Foxo1 signaling in mice
- … crocetin and the synthetic tellurium compound AS101 protect the ovary against cyclophosphamide by modulating SIRT1 and mitochondrial markers
- Prognostic and clinical value of SIRT1 expression in gastric cancer: A systematic meta-analysis
- SIRT1 reduction is associated with sex-specific dysregulation of renal lipid metabolism and stress responses in offspring by maternal high-fat diet
- Nampt expression decreases age-related senescence in rat bone marrow mesenchymal stem cells by targeting SIRT1
- (–)-Epicatechin suppresses angiotensin II-induced cardiac hypertrophy via the activation of the SP1/SIRT1 signaling pathway
- Bushen-Yizhi formula ameliorates cognitive dysfunction through SIRT1/ER stress pathway in SAMP8 mice
- Resveratrol enhances HBV replication through activating SIRT1-PGC-1α-PPARα pathway
- Dysregulation of the SIRT1/OCT6 axis contributes to environmental stress-induced neural induction defects
- The metabolic sensor SIRT1 and the hypothalamus: Interplay between peptide hormones and pro-hormone convertases
- A novel role of SIRT1/FGF-21 in taurine protection against cafeteria diet-induced steatohepatitis in rats
- Identification of a tissue-restricted isoform of SIRT1 defines a regulatory domain that encodes specificity
- Regulation of stem cell aging by SIRT1–Linking metabolic signaling to epigenetic modifications
- Salidroside inhibits HMGB1 acetylation and release through upregulation of SIRT1 during inflammation
- Extracellular NAMPT/visfatin causes p53 deacetylation via NAD production and SIRT1 activation in breast cancer cells
- Role of SIRT1 as a Regulator of Autophagy
- VISFATIN (NAMPT) improves in vitro IGF1-induced steroidogenesis and IGF1 receptor signaling through SIRT1 in bovine granulosa cells
- miR-29b overexpression induces cochlear hair cell apoptosis through the regulation of SIRT1/PGC-1α signaling: Implications for age-related hearing loss
- Capsaicin protects cardiomyocytes against anoxia/reoxygenation injury via preventing mitochondrial dysfunction mediated by SIRT1
- Loss of miR-449a in ERG-associated prostate cancer promotes the invasive phenotype by inducing SIRT1
- The UCA1/miR-204/SIRT1 axis modulates docetaxel sensitivity of prostate cancer cells
- … proliferator-activated receptor γ agonist pioglitazone prevents NF-κB activation in cisplatin nephrotoxicity through the reduction of p65 acetylation via the AMPK-SIRT1 …
- Treadmill exercise attenuates α-synuclein levels by promoting mitochondrial function and autophagy possibly via SIRT1 in the chronic MPTP/P-induced mouse model …
- Resveratrol attenuates microglial activation via SIRT1-SOCS1 pathway
- Altered expression of micro-RNA 199a and increased levels of cardiac SIRT1 protein are associated with the occurrence of atrial fibrillation after coronary artery …
- Resveratrol protects against L-arginine-induced acute necrotizing pancreatitis in mice by enhancing SIRT1-mediated deacetylation of p53 and heat shock …
- MicroRNA-200a is up-regulated in aged rats with erectile dysfunction and could attenuate endothelial function via SIRT1 inhibition
- Identification of new inhibitors for human SIRT1: an in-silico approach
- Isoalantolactone induces apoptosis in human breast cancer cells via ROS-mediated mitochondrial pathway and downregulation of SIRT1
- … PC12 cells from tunicamycin-mediated cell death via reactive oxygen species scavenging and modulation of Nrf2-driven gene expression, SIRT1 and MAPK signaling …
- Hypermethylation of the HIC1 promoter and aberrant expression of HIC1/SIRT1 contribute to the development of thyroid papillary carcinoma
- Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1
- SIRT1-AMPK crosstalk is involved in high glucose-dependent impairment of insulin responsiveness in primary rat podocytes
- Sirt7 stabilizes rDNA heterochromatin through recruitment of DNMT1 and SIRT1
- SIRT1 inhibition impairs non-homologous end joining DNA damage repair by increasing Ku70 acetylation in chronic myeloid leukemia cells
- Different lipopolysaccharide branched-chain amino acids modulate porcine intestinal endogenous β-defensin expression through the SIRT1/ERK/90RSK pathway
- SIRT1 regulates lipopolysaccharide-induced CD40 expression in renal medullary collecting duct cells by suppressing the TLR4-NF-κB signaling pathway
- SIRT1-dependent modulation of methylation and acetylation of histone H3 on lysine 9 (H3K9) in the zygotic pronuclei improves porcine embryo development
- Chronic administration tetrahydroxystilbene glucoside promotes hippocampal memory and synaptic plasticity and activates ERKs, CaMKII and SIRT1/miR-134 in vivo
- Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients
- hnRNP A1 antagonizes cellular senescence and senescence‐associated secretory phenotype via regulation of SIRT1 mRNA stability
- SIRT1 confers protection against ischemia/reperfusion injury in cardiomyocytes via regulation of uncoupling protein 2 expression
- SIRT1-mediated deacetylation of PGC1α attributes to the protection of curcumin against glutamate excitotoxicity in cortical neurons
- Resveratrol induces human keratinocyte damage via the activation of class III histone deacetylase, SIRT1
- HDAC4 mediates IFN-γ induced disruption of energy expenditure-related gene expression by repressing SIRT1 transcription in skeletal muscle cells
- Identifying human SIRT1 substrates by integrating heterogeneous information from various sources
- Melatonin protects skin keratinocyte from hydrogen peroxide-mediated cell death via the SIRT1 pathway
- Long non-coding RNA TUG1 promotes cervical cancer progression by regulating the miR-138-5p-SIRT1 axis
- Adiponectin protects against glutamate-induced excitotoxicity via activating SIRT1-dependent PGC-1 expression in HT22 hippocampal neurons
- Temporal overexpression of SIRT1 in skeletal muscle of adult mice does not improve insulin sensitivity or markers of mitochondrial biogenesis
- Acute treatment of resveratrol alleviates doxorubicin-induced myotoxicity in aged skeletal muscle through SIRT1-dependent mechanisms
- SIRT1 exerts neuroprotective effects by attenuating cerebral ischemia/reperfusion-induced injury via targeting p53/microRNA-22
- ZLN005 protects cardiomyocytes against high glucose-induced cytotoxicity by promoting SIRT1 expression and autophagy
- Mst1 regulates hepatic lipid metabolism by inhibiting SIRT1 ubiquitination in mice
- 1, 25-dihydroxy-vitamin D3 with tumor necrosis factor-alpha protects against rheumatoid arthritis by promoting p53 acetylation-mediated apoptosis via SIRT1 in …
- … compatibility of Aconiti Lateralis Radix Praeparata and Zingiberis Rhizoma on rats with heart failure by enhancing mitochondrial biogenesis via SIRT1/PGC-1α pathway
- Carbon Monoxide Potentiation of L-Type Ca2+ Channel Activity Increases HIF-1α-Independent VEGF Expression via an AMPKα/SIRT1-Mediated PGC-1α/ERRα …
- MicroRNA-34a negatively regulates efferocytosis by tissue macrophages in part via SIRT1
- SIRT1 suppresses Wnt/βCatenin signaling in liver cancer cells by targeting βCatenin in a PKAα-dependent manner
- Visfatin attenuates the ox-LDL-induced senescence of endothelial progenitor cells by upregulating SIRT1 expression through the PI3K/Akt/ERK pathway
- Protection of CD4+ T cells from hepatitis C virus infection‐associated senescence via ΔNp63–miR‐181a–SIRT1 pathway
- SIRT1 mediates improvement in cognitive defects induced by focal cerebral ischemia following hyperbaric oxygen preconditioning in rats
- Adiponectin suppresses T helper 17 cell differentiation and limits autoimmune CNS inflammation via the SIRT1/PPARγ/RORγt pathway
- NFAT5 protects astrocytes against oxygen–glucose–serum deprivation/restoration damage via the SIRT1/Nrf2 pathway
- MiR-204 enhances mitochondrial apoptosis in doxorubicin-treated prostate cancer cells by targeting SIRT1/p53 pathway
- The combination of blueberry juice and probiotics reduces apoptosis of alcoholic fatty liver of mice by affecting SIRT1 pathway
- Ultraviolet B inhibition of DNMT1 activity via AhR activation dependent SIRT1 suppression in CD4+ T cells from systemic lupus erythematosus patients
- Docosahexaenoic acid attenuates adipose tissue angiogenesis and insulin resistance in high fat diet‐fed middle‐aged mice via a SIRT1‐dependent mechanism
- Hepatitis C virus core protein impairs metabolic disorder of liver cell via HOTAIR-SIRT1 signalling
- SIRT1 increases YAP-and MKK3-dependent p38 phosphorylation in mouse liver and human hepatocellular carcinoma
- The SIRT1/NF-kB signaling pathway is involved in regulation of endothelin type B receptors mediated by homocysteine in vascular smooth muscle cells
- Retinoic acid ameliorates high-fat diet-induced liver steatosis through SIRT1
- Scopolin ameliorates high-fat diet induced hepatic steatosis in mice: potential involvement of SIRT1-mediated signaling cascades in the liver
- Treatment with NAD+ inhibited experimental autoimmune encephalomyelitis by activating AMPK/SIRT1 signaling pathway and modulating Th1/Th17 immune …
- Hypoxia-inducible factor 1 alpha promotes cancer stem cells-like properties in human ovarian cancer cells by upregulating SIRT1 expression
- Resveratrol attenuates Aβ 25–35 caused neurotoxicity by inducing autophagy through the TYrRS-PARP1-SIRT1 signaling pathway
- Depigmenting effect of resveratrol is dependent on FOXO3a activation without SIRT1 activation
- Assessing colonic exposure, safety, and clinical activity of SRT2104, a novel oral SIRT1 activator, in patients with mild to moderate ulcerative colitis
- SIRT1 is a critical regulator of K562 cell growth, survival, and differentiation
- Vav1 regulates mesenchymal stem cell differentiation decision between adipocyte and chondrocyte via SIRT1
- Oligonol promotes anti-aging pathways via modulation of SIRT1-AMPK-Autophagy Pathway
- … myocardial ischemia–reperfusion injury by reducing oxidative stress and endoplasmic reticulum stress-mediated apoptosis in type 1 diabetic rats: role of SIRT1 …
- Resveratrol inhibits adventitial fibroblast proliferation and induces cell apoptosis through the SIRT1 pathway
- AMPK↔ SIRT1: from a signaling network to a combination drug
- Fibroblast growth factor 21 (FGF21) promotes formation of aerobic myofibers via the FGF21‐SIRT1‐AMPK‐PGC1α pathway
- Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3
- Mesenchymal stem cells with SIRT1 overexpression suppress breast tumor growth via chemokine-dependent natural killer cells recruitment
- Resveratrol attenuated estrogen-deficient-induced cardiac dysfunction: Role of AMPK, SIRT1, and mitochondrial function
- Resveratrol attenuated TNF-α–induced MMP-3 expression in human nucleus pulposus cells by activating autophagy via AMPK/SIRT1 signaling pathway
- Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis
- Finding Potent Sirt Inhibitor in Coffee: Isolation, Confirmation and Synthesis of Javamide-II (N-Caffeoyltryptophan) as SIRT1/2 Inhibitor
- MEK1 signaling promotes self-renewal and tumorigenicity of liver cancer stem cells via maintaining SIRT1 protein stabilization
- Mangiferin protects retinal ganglion cells in ischemic mouse retina via SIRT1
- SIRT1 gene polymorphisms and risk of lung cancer
- Sulforaphane prevents rat cardiomyocytes from hypoxia/reoxygenation injury in vitro via activating SIRT1 and subsequently inhibiting ER stress
- Chikusetsu saponin V attenuates H2O2-induced oxidative stress in human neuroblastoma SH-SY5Y cells through SIRT1/PGC-1α/Mn-SOD signaling pathways
- Ampelopsin attenuates the atrophy of skeletal muscle from d-gal-induced aging rats through activating AMPK/SIRT1/PGC-1α signaling cascade
- miR‐204‐5p targeting SIRT1 regulates hepatocellular carcinoma progression
- Omega-3 polyunsaturated fatty acids suppress the inflammatory responses of lipopolysaccharide-stimulated mouse microglia by activating SIRT1 pathways
- MicroRNA-133b inhibits cell proliferation and invasion in osteosarcoma by targeting SIRT1
- Functional characterization of NAD dependent de-acetylases SIRT1 and SIRT2 in B-cell chronic lymphocytic leukemia (CLL)
- Circulating SIRT1 inversely correlates with epicardial fat thickness in patients with obesity
- Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway
- Resveratrol protects against high-fat diet induced renal pathological damage and cell senescence by activating SIRT1
- Metformin regulates oxLDL-facilitated endothelial dysfunction by modulation of SIRT1 through repressing LOX-1-modulated oxidative signaling
- Anti-atherogenic properties of resveratrol: 4-week resveratrol administration associated with serum concentrations of SIRT1, adiponectin, S100A8/A9 and …
- microRNA-182 mediates SIRT1-induced diabetic corneal nerve regeneration
- Hydrogen rich water attenuates renal injury and fibrosis by regulation transforming growth factor-β induced SIRT1
- Anti-fibrotic effect of losartan, an angiotensin II receptor blocker, is mediated through inhibition of ER stress via up-regulation of SIRT1, followed by induction of HO-1 …
- Salidroside suppresses inflammation in a D-galactose-induced rat model of Alzheimer’s disease via SIRT1/NF-κB pathway
- Effects of the small molecule SIRT1 activator, SRT2104 on arterial stiffness in otherwise healthy cigarette smokers and subjects with type 2 diabetes mellitus
- 1, 4-Dihydropyridines active on the SIRT1/AMPK pathway ameliorate skin repair and mitochondrial function and exhibit inhibition of proliferation in cancer cells
- Artesunate protects pancreatic beta cells against cytokine-induced damage via SIRT1 inhibiting NF-κB activation
- Melatonin inhibits SIRT1-dependent NAMPT and NFAT5 signaling in chondrocytes to attenuate osteoarthritis
- Hydrogen sulfide attenuates inflammatory hepcidin by reducing IL-6 secretion and promoting SIRT1-mediated STAT3 deacetylation
- Emodin suppresses silica-induced lung fibrosis by promoting SIRT1 signaling via direct contact
- Biogenesis of pro-senescent microparticles by endothelial colony forming cells from premature neonates is driven by SIRT1-dependent epigenetic regulation …
- HSP25 down-regulation enhanced p53 acetylation by dissociation of SIRT1 from p53 in doxorubicin-induced H9c2 cell apoptosis
- Extremely low-frequency electromagnetic field promotes astrocytic differentiation of human bone marrow mesenchymal stem cells by modulating SIRT1 expression
- Underlying mechanism of SIRT1 on apoptosis and extracellular matrix degradation of osteoarthritis chondrocytes
- Rehabilitation training and resveratrol improve the recovery of neurological and motor function in rats after cerebral ischemic injury through the SIRT1 signaling …
- SIRT1 overexpression in cervical squamous intraepithelial lesions and invasive squamous cell carcinoma
- Betulinic acid derivative B10 inhibits glioma cell proliferation through suppression of SIRT1, acetylation of FOXO3a and upregulation of Bim/PUMA
- Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function
- Carbocysteine counteracts the effects of cigarette smoke on cell growth and on the SIRT1/FoxO3 axis in bronchial epithelial cells
- Distinct effects of SIRT1 in cancer and stromal cells on tumor promotion
- Endogenous Nampt upregulation is associated with diabetic nephropathy inflammatory‑fibrosis through the NF‑κB p65 and SIRT1 pathway; NMN alleviates …
- Sevoflurane ameliorates myocardial cell injury by inducing autophagy via the deacetylation of LC3 by SIRT1
- Sirtuin 1 (SIRT1) overexpression in BaF3 cells contributes to cell proliferation promotion, apoptosis resistance and pro-inflammatory cytokine production
- Multi-regulatory network of ROS: the interconnection of ROS, PGC-1 alpha, and AMPK-SIRT1 during exercise
- The role of de novo protein synthesis and SIRT1 in ER stress-induced Atf4 and Chop mRNA expression in mammalian cells
- Resveratrol controlled the fate of porcine pancreatic stem cells through the Wnt/β-catenin signaling pathway mediated by SIRT1
- SRT1720, a SIRT1 specific activator, protected H2O2-induced senescent endothelium
- Juglone up-regulates SIRT1 in skin cells under normal and UVB irradiated conditions
- Ligand-based virtual screening and inductive learning for identification of SIRT1 inhibitors in natural products
- The nutrient and energy sensor SIRT1 regulates the hypothalamic-pituitary-adrenal (HPA) axis by altering the production of the prohormone convertase 2 (PC2) …
- mTOR signaling promotes foam cell formation and inhibits foam cell egress through suppressing the SIRT1 signaling pathway
- Hydrogen alleviates hyperoxic acute lung injury related endoplasmic reticulum stress in rats through upregulation of SIRT1
- Palmitic acid interferes with energy metabolism balance by adversely switching the SIRT1-CD36-fatty acid pathway to the PKC zeta-GLUT4-glucose pathway in …
- Targeting SIRT1 in a rat model of high‑fat diet‑induced non‑alcoholic fatty liver disease: Comparison of Gegen Qinlian decoction and resveratrol
- miR-543 promotes gastric cancer cell proliferation by targeting SIRT1
- Effects of nasal CPAP on exhaled SIRT1 and tumor necrosis factor-α in patients with obstructive sleep apnea
- Adiponectin upregulates filaggrin expression via SIRT1-mediated signaling in human normal keratinocytes
- Over-expression of heat shock protein 70 protects mice against lung ischemia/reperfusion injury through SIRT1/AMPK/eNOS pathway
- TWEAK increases SIRT1 expression and promotes p53 deacetylation affecting human hepatic stellate cell senescence
- Carboxyamidotriazole alleviates muscle atrophy in tumor-bearing mice by inhibiting NF-κB and activating SIRT1
- Endothelial LOX-1 activation differentially regulates arterial thrombus formation depending on oxLDL levels: role of the Oct-1/SIRT1 and ERK1/2 pathways
- PDE5 inhibition ameliorates visceral adiposity targeting the miR-22/SIRT1 pathway: evidence from the CECSID trial
- microRNA‑34a overexpression inhibits cell migration and invasion via regulating SIRT1 in hepatocellular carcinoma Corrigendum in/10.3892/ol. 2019.11048
- Post-translational regulation contributes to the loss of LKB1 expression through SIRT1 deacetylase in osteosarcomas
- Nicotinic acid inhibits NLRP3 inflammasome activation via SIRT1 in vascular endothelial cells
- AML1–ETO promotes SIRT1 expression to enhance leukemogenesis of t (8; 21) acute myeloid leukemia
- Effect of sodium salt of Butrin, a novel compound isolated from Butea monosperma flowers on suppressing the expression of SIRT1 and Aurora B kinase-mediated …
- MiR-21 regulates TNF-α-induced CD40 expression via the SIRT1-NF-κB pathway in renal inner medullary collecting duct cells
- High glucose and free fatty acids induce endothelial progenitor cell senescence via PGC‐1α/SIRT1 signaling pathway
- Protective effects of isorhamnetin on cardiomyocytes against anoxia/reoxygenation-induced injury is mediated by SIRT1
- … sepsis‑induced myocardial injury in rats by suppressing neutrophil accumulation, the induction of TNF‑α and myocardial apoptosis via activation of SIRT1
- Melatonin protects chondrocytes from impairment induced by glucocorticoids via NAD+-dependent SIRT1
- Overexpressed eNOS upregulates SIRT1 expression and protects mouse pancreatic β cells from apoptosis
- SIRT1 activity is decreased in lesional psoriatic skin
- AAV-mediated SIRT1 overexpression in skeletal muscle activates oxidative capacity but does not prevent insulin resistance
- Inhibitory effects of SRT1720 on the apoptosis of rabbit chondrocytes by activating SIRT1 via p53/bax and NF-κB/PGC-1α pathways
- Mesenchymal stem cells overexpressing SIRT1 inhibit prostate cancer growth by recruiting natural killer cells and macrophages
- Resveratrol improved the progression of chronic prostatitis via the downregulation of c-kit/SCF by activating SIRT1
- Replicative Senescence in Human Fibroblasts Is Delayed by Hydrogen Sulfide in a NAMPT/SIRT1 Dependent Manner
- Bivalent SIRT1 inhibitors
- miR-22 suppresses tumorigenesis and improves radiosensitivity of breast cancer cells by targeting SIRT1
- GLP-1 receptor agonist promotes brown remodelling in mouse white adipose tissue through SIRT1
- SIRT1 inhibits EV71 genome replication and RNA translation by interfering with the viral polymerase and 5′ UTR RNA
- Resveratrol promotes recovery of hearing following intense noise exposure by enhancing cochlear SIRT1 activity
- Leucine-nicotinic acid synergy stimulates AMPK/SIRT1 signaling and regulates lipid metabolism and lifespan in Caenorhabditis elegans, and hyperlipidemia …
- Response of BAX, Bcl-2 proteins, and SIRT1/PGC-1α mRNA expression to 8-week treadmill running in the aging rat skeletal muscle
- SIRT1 at the crossroads of AKT1 and ERβ in malignant pleural mesothelioma cells
- MiR-138-5p promotes TNF-α-induced apoptosis in human intervertebral disc degeneration by targeting SIRT1 through PTEN/PI3K/Akt signaling
- SIRT1 inhibits releases of HMGB1 and HSP70 from human umbilical vein endothelial cells caused by IL-6 and the serum from a preeclampsia patient and protects the …
- … present at high levels in bitter melon seed favorably affects lipid metabolism in hepatocytes by increasing NAD+/NADH ratio and activating PPARα, AMPK and SIRT1 …
- Alteration of muscle fiber characteristics and the AMPK-SIRT1-PGC-1α axis in skeletal muscle of growing pigs fed low-protein diets with varying branched …
- Inhibiting microRNA-449 attenuates cisplatin-induced injury in NRK-52E cells possibly via regulating the SIRT1/P53/BAX pathway
- Effects of microRNA-211 on proliferation and apoptosis of lens epithelial cells by targeting SIRT1 gene in diabetic cataract mice
- … : Polysaccharide from Angelica sinensis ameliorates high-fat diet and STZ-induced hepatic oxidative stress and inflammation in diabetic mice by activating the SIRT1 …
- Reversible modulation of SIRT1 activity in a mouse strain
- Expression profiles of SIRT1 and APP genes in human neuroblastoma SK-N-SH cells treated with two epigenetic agents
- SIRT1 prevents pulmonary thrombus formation induced by arachidonic acid via downregulation of PAF receptor expression in platelets
- De-novo NAD+ synthesis regulates SIRT1-FOXO1 apoptotic pathway in response to NQO1 substrates in lung cancer cells
- miR-138-5p suppresses autophagy in pancreatic cancer by targeting SIRT1
- SIRT1 promotes tumor-like invasion of fibroblast-like synoviocytes in rheumatoid arthritis via targeting TIMP1
- Brachyury promotes tamoxifen resistance in breast cancer by targeting SIRT1
- Chikusetsu saponin IVa attenuates isoflurane-induced neurotoxicity and cognitive deficits via SIRT1/ERK1/2 in developmental rats
- Resveratrol exerts protective effects on anoxia/reoxygenation injury in cardiomyocytes via miR-34a/SIRT1 signaling pathway
- MicroRNA-141 targets SIRT1 and inhibits autophagy to reduce HBV replication
- MiR-377 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity via suppression of sirtuin-1 (SIRT1)
- Zerumbone ameliorates high-fat diet-induced adiposity by restoring AMPK-regulated lipogenesis and microRNA-146b/SIRT1-mediated adipogenesis
- … implicated in ionizing radiation-induced premature ovarian failure through antagonistic crosstalk between silencing information regulator 1 (SIRT1) and poly (ADP …
- NAMPT protects against 6-hydroxydopamine-induced neurotoxicity in PC12 cells through modulating SIRT1 activity
- CHFR negatively regulates SIRT1 activity upon oxidative stress
- Omega-3 polyunsaturated fatty acids alleviate hepatic steatosis-induced inflammation through SIRT1-mediated nuclear translocation of NF-κB p65 subunit in …
- CR6-interacting factor 1 deficiency impairs vascular function by inhibiting the SIRT1-endothelial nitric oxide synthase pathway
- Methylene blue alleviates experimental autoimmune encephalomyelitis by modulating AMPK/SIRT1 signaling pathway and Th17/Treg immune response
- Communication from tubular epithelial cells to podocytes through SIRT1 and nicotinic acid metabolism
- MicroRNA-22 inhibits cell growth and metastasis in breast cancer via targeting of SIRT1
- Association of FGFR2 rs2981582, SIRT1 rs12778366, STAT3 rs744166 gene polymorphisms with pituitary adenoma
- Aldehyde dehydrogenase 2 activation in aged heart improves the autophagy by reducing the carbonyl modification on SIRT1
- The long non-coding RNA MALAT1 promotes the migration and invasion of hepatocellular carcinoma by sponging miR-204 and releasing SIRT1
- Homocysteine up-regulates endothelin type A receptor in vascular smooth muscle cells through SIRT1/ERK1/2 signaling pathway
- SIRT1 signaling pathway mediated the protective effects on myocardium of rats after endurance training and acute exhaustive exercise
- miR-138 suppresses the proliferation, metastasis and autophagy of non-small cell lung cancer by targeting SIRT1
- Impact of SIRT1 gene expression on the development and treatment of the metabolic syndrome in oncological patients
- 1,25(OH)2D3 improves cardiac dysfunction, hypertrophy, and fibrosis through PARP1/SIRT1/mTOR‐related mechanisms in type 1 diabetes
- Are SIRT1 activators another indirect method to increase AMPK for beneficial effects on aging and the metabolic syndrome?
- miR-22 inhibits the proliferation, motility, and invasion of human glioblastoma cells by directly targeting SIRT1
- miR-204 regulates the proliferation of dairy goat spermatogonial stem cells via targeting to SIRT1
- miR-22 inhibits mouse ovarian granulosa cell apoptosis by targeting SIRT1
- Lin28a protects against postinfarction myocardial remodeling and dysfunction through SIRT1 activation and autophagy enhancement
- Highly sensitive electrochemical immunoassay integrated with polymeric nanocomposites and enhanced SiO2@ Au core-shell nanobioprobes for SIRT1 determination
- Fibroblast growth factor 21 delayed endothelial replicative senescence and protected cells from H2O2-induced premature senescence through SIRT1
- Hydroquinone-induced malignant transformation of TK6 cells by facilitating SIRT1-mediated p53 degradation and up-regulating KRAS
- AdipoR1-mediated miR-3908 inhibits glioblastoma tumorigenicity through downregulation of STAT2 associated with the AMPK/SIRT1 pathway
- Beneficial effects of omega-3 and vitamin E coadministration on gene expression of SIRT1 and PGC1α and serum antioxidant enzymes in patients with coronary artery …
- Targeting the interaction of Aurora kinases and SIRT1 mediated by Wnt signaling pathway in colorectal cancer: A critical review
- MicroRNA-22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma
- SIRT1‑mediated regulation of oxidative stress induced by Pseudomonas aeruginosa lipopolysaccharides in human alveolar epithelial cells
- Reverse chemomodulatory effects of the SIRT1 activators resveratrol and SRT1720 in Ewing’s sarcoma cells: resveratrol suppresses and SRT1720 enhances …
- In patients with coronary artery disease and type 2 diabetes, SIRT1 expression in circulating mononuclear cells is associated with levels of inflammatory …
- SIRT1-mediated downregulation of p27Kip1 is essential for overcoming contact inhibition of Kaposi’s sarcoma-associated herpesvirus transformed cells
- A minicircuitry comprised of microRNA-9 and SIRT1 contributes to leukemogenesis in t (8; 21) acute myeloid leukemia
- SIRT1 attenuated oxidative stress induced by methyl tert-butyl ether in HT22 cells
- SIRT1 regulates accumulation of oxidized LDL in HUVEC via the autophagy-lysosomal pathway
- Central metabolic sensing remotely controls nutrient-sensitive endocrine response in Drosophila via Sir2/SIRT1–upd2–IIS axis
- The NAD World 2.0: the importance of the inter-tissue communication mediated by NAMPT/NAD+/SIRT1 in mammalian aging and longevity control
- Metabolism of 20 (S)-Ginsenoside Rg2 by rat liver microsomes: bioactivation to SIRT1-activating metabolites
- Methylation changes of SIRT1, KLF4, DAPK1 and SPG20 in B-lymphocytes derived from follicular and diffuse large B-cell lymphoma
- Differential effects of estradiol and bisphenol A on SET8 and SIRT1 expression in ovarian cancer cells
- … of extracellular calcium influx results in enhanced IL-12 production in LPS-treated murine macrophages by downregulation of the CaMKK-AMPK-SIRT1 …
- Effects of SIRT1 gene knock-out via activation of SREBP2 protein-mediated PI3K/AKT signaling on osteoarthritis in mice
- The aldehyde group of gossypol induces mitochondrial apoptosis via ROS-SIRT1-p53-PUMA pathway in male germline stem cell
- Lactobacillus brevis T2102 suppresses the growth of colorectal cancer cells by activating SIRT1
- Localization of sirtuins (SIRT1-7) in the aged mouse inner ear
- Sirtuin1 (SIRT1) regulates tumor necrosis factor-alpha (TNF-α-Induced) aquaporin-2 (AQP2) expression in renal medullary collecting duct cells through …
- Suppression of miR-301a alleviates LPS-induced inflammatory injury in ATDC5 chondrogenic cells by targeting SIRT1
- Beraprost sodium, a prostacyclin analogue, reduces fructose-induced hepatocellular steatosis in mice and in vitro via the microRNA-200a and SIRT1 signaling …
- Common SIRT1 variants modify the effect of abdominal adipose tissue on aging-related lung function decline
- microRNA-199a-5p mediates high glucose-induced reactive oxygen species production and apoptosis in INS-1 pancreatic ß-cells by targeting SIRT1
- Expression of cellular protective proteins SIRT1, HSP70 and SOD2 correlates with age and is significantly higher in NK cells of the oldest seniors
- Breast cancer metastasis suppressor 1 modulates SIRT1-dependent p53 deacetylation through interacting with DBC1
- Brain-derived neurotrophic factor Val66Met polymorphism in depression and thrombosis: SIRT1 as a possible mediator
- 0404 inhibits hepatocellular carcinoma through a p53/miR-34a/SIRT1 positive feedback loop
- MicroRNA-132 cause apoptosis of glioma cells through blockade of the SREBP-1c metabolic pathway related to SIRT1
- Polymorphism in the SIRT1 gene and parameters of metabolic syndrome in a sample of the adult Brazilian population
- MicroRNA-138 inhibits cell proliferation in hepatocellular carcinoma by targeting SIRT1
- Resveratrol inhibits age-dependent spontaneous tumorigenesis by SIRT1-mediated post-translational modulations in the annual fish Nothobranchius …
- mGluR2/3 activation of the SIRT1 axis preserves mitochondrial function in diabetic neuropathy
- Oleic acid activates MMPs up-regulation through SIRT1/PPAR-γ inhibition: A probable linkage between obesity and coronary arterial disease
- SIRT1 expression is refractory to hypoxia and inflammatory cytokines in nucleus pulposus cells: Novel regulation by HIF‐1α and NF‐κB signaling
- SIRT1 controls cell proliferation by regulating contact inhibition
- … (3D-QSAR) modeling combined with virtual screening to identify novel small-molecule inhibitors of silent mating-type information regulation 2 homologue 1 (SIRT1)
- Polydatin improves the developmental competence of bovine embryos in vitro via induction of sirtuin 1 (SIRT1)
- Protective effect of unacylated ghrelin on compression-induced skeletal muscle injury mediated by SIRT1-signaling
- Obesity accelerates murine gastric cancer growth by modulating the SIRT1/YAP pathway
- DJ-1 activates SIRT1 through its direct binding to SIRT1
- #VALUE!
- microRNA‑494 is a potential prognostic marker and inhibits cellular proliferation, migration and invasion by targeting SIRT1 in epithelial ovarian cancer
- Carnosic acid attenuates acute ethanol-induced liver injury via a SIRT1/p66Shc-mediated mitochondrial pathway
- SIRT1 activation mediates heat-induced survival of UVB damaged Keratinocytes
- Deletion of SIRT1 in myeloid cells impairs glucose metabolism with enhancing inflammatory response to adipose tissue hypoxia
- Differential expression of circadian genes in leukemia and a possible role for SIRT1 in restoring the circadian clock in chronic myeloid leukemia
- Is SIRT6 activity neuroprotective and how does it differ from SIRT1 in this regard?
- PU. 1-deficient mice are resistant to thioacetamide-induced hepatic fibrosis: PU. 1 finely regulates SIRT1 expression via transcriptional promotion of miR-34a …
- Tat-mediated induction of miRs-34a &-138 promotes astrocytic activation via downregulation of SIRT1: implications for aging in HAND
- Sildenafil protects against bile duct ligation induced hepatic fibrosis in rats: Potential role for silent information regulator 1 (SIRT1)
- Anti-diabetic activity of fused PPARγ-SIRT1 ligands with limited body-weight gain by mimicking calorie restriction and decreasing SGK1 expression
- Synergic chemoprevention with dietary carbohydrate restriction and supplementation of AMPK-activating phytochemicals: the role of SIRT1
- CAY10591, a SIRT1 activator, suppresses cell growth, invasion, and migration in gingival epithelial carcinoma cells
- Exosomal miR-486 regulates hypoxia-induced erythroid differentiation of erythroleukemia cells through targeting SIRT1
- Overcoming ATM deficiency by activating the NAD+/SIRT1 axis
- G004, a synthetic sulfonylurea compound, exerts anti-atherosclerosis effects by targeting SIRT1 in ApoE−/− mice
- Intracerebroventricular tempol administration in older rats reduces oxidative stress in the hypothalamus but does not change STAT3 signalling or SIRT1/AMPK …
- Acetylome study in mouse adipocytes identifies targets of SIRT1 deacetylation in chromatin organization and RNA processing
- NS5ATP6 modulates intracellular triglyceride content through FGF21 and independently of SIRT1 and SREBP1
- Tris (2‐chloroethyl) phosphate‐induced cell growth arrest via attenuation of SIRT1‐independent PI3K/Akt/mTOR pathway
- Altered microRNA-9 expression level is directly correlated with pathogenesis of nonalcoholic fatty liver disease by targeting Onecut2 and SIRT1
- Resveratrol improves smooth muscle carcinogenesis in the progression of chronic prostatitis via the downregulation of c-kit/SCF by activating SIRT1
- Possible association between SIRT1 single nucleotide polymorphisms and predisposition to antisocial personality traits in Chinese adolescents
- Upregulation of MKP-7 in response to rosiglitazone treatment ameliorates lipopolysaccharide-induced destabilization of SIRT1 by inactivating JNK
- Transcriptional coactivator p300 and silent information regulator 1 (SIRT1) gene polymorphism associated with diabetic kidney disease in a Chinese cohort
- Effects of self-reported calorie restriction on correlations between SIRT1 polymorphisms and body mass index and long-term weight change
- The silent information regulator 1 (SIRT1) is a positive regulator of the Notch pathway in Drosophila
- Understanding genetic heterogeneity in type 2 diabetes by delineating physiological phenotypes: SIRT1 and its gene network in impaired insulin secretion
- The gender association of the SIRT1 rs7895833 polymorphism with pediatric obesity: a 3-year panel study
- Effect of daisaikoto on expressions of SIRT1 and NF-kappaB of diabetic fatty liver rats induced by high-fat diet and streptozotocin
- 1, 2, 3-Triazole-dithiocarbamate hybrids, a group of novel cell active SIRT1 inhibitors
- To Stay Happy, Keep Your SIRT1 Active
- Paliperidone Protects SH-SY5Y Cells Against MK-801-Induced Neuronal Damage Through Inhibition of Ca2+ Influx and Regulation of SIRT1/miR-134 Signal …
- SIRT1 gene polymorphisms associated with carcass traits in Luxi cattle
- Cyclic peptide-based potent and selective SIRT1/2 dual inhibitors harboring Nε-thioacetyl-lysine
- Lycium barbarum polysaccharides enhances SIRT1 expression and decreases MMP-9 and HIF-1α expressions in hypoxic pulmonary vascular smooth muscle cells
- SIRT1 Influences the sensitivity of A549 non-small cell lung cancer cell line to cisplatin via modulating the Noxa expression
- Suppressive effect of microRNA-138 on the proliferation and invasion of osteosarcoma cells via targeting SIRT1
- Activation of SIRT1 deacetylase as a therapeutic approach for myelodysplastic syndromes by restoring TET2 function
- miR-138 promotes migration and tube formation of human cytomegalovirus-infected endothelial cells through the SIRT1/p-STAT3 pathway
- Resveratrol suppresses P-selectin, PSGL-1, and VWF through SIRT1 signaling pathway
- Effect of Kangshuanyihao Formula on the Inflammatory Reaction and SIRT1/TLR4/NF-κB Signaling Pathway in Endothelial Injury
- The impact of a 48-h fast on SIRT1 and GCN5 in human skeletal muscle
- Giardia duodenalis GlSir2. 2, homolog of SIRT1, is a nuclear-located and NAD+-dependent deacethylase
- SIRT1 Regulates p53 Stability and Expression of Its Target S100B during Long-Term Potentiation in Rat Hippocampus
- FOXO3a & haematopoietic stem cells: Goodbye PI3K, hello SIRT1?
- A novel Ubc9-dependent pathway regulates SIRT1-ER-α Axis and BRCA1-associated TNBC lung metastasis
- SIRT1-positive lymphocytes in acute cellular cardiac allograft rejection: contributor to pathogenesis and a therapeutic target
- SIRT1 gene polymorphisms and its protein level in colorectal cancer
- Morphoproteomics identifies SIRT1 and EZH2 pathways as commonalities in B-cell acute lymphoblastic leukemia: pathogenetic implications and opportunities for …
- B31 SIRT1 expression, regulation and activity in R6/2 mice
- Protein inhibitor of activated STAT 4 (PIAS4) regulates pro-inflammatory transcription in hepatocytes by repressing SIRT1
- GW28-e0635 Quercetin retards progression of Diabetic cardiomyopathy through modulations of SIRT1 and AMP-activated protein kinase
- The effects of siRNA SIRT1 on the proliferation of human cervical cancer cells
- #VALUE!
- Association of single nucleotide polymorphism of SIRT1 and APOC3 with nonalcoholic fatty liver disease
- KDM2B is a histone H3K79 demethylase and induces transcriptional repression via SIRT1-mediated chromatin silencing
- Protective effects and mechanism of SIRT1 for the regulation of p38 MAPK pathway on retinal ganglion cells in rats with diabetic retinopathy
- Updated roles of SIRT1 in prostate diseases
- SIRT1 in metabolic health and disease
- Guttiferone A aggregates modulate silent information regulator 1 (SIRT1) activity
- SAT0046 Regulation of SIRT1 Maybe A Pioneering Strategy in Treatment of Rheumatoid Arthritis
- SIRT1 puts an embargo on mRNA export
- Alteration of Wnt/β-catenin signaling pathway in type2 diabetic rats’ aorta and regulation of SIRT1
- Loss of SIRT1 impairs autophagy in chondrocytes and is associated with accelerated cartilage aging and experimental osteoarthritis
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- Correction: SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington’s Disease Mice
- Propofol alleviates hepatic ischemia/reperfusion injury via the activation of the SIRT1 pathway
- Whey Protein Attenuates Angiotensin II-Primed Premature Senescence of Vascular Smooth Muscle Cells through Upregulation of SIRT1
- Is the regulation of SIRT1 by miRNA-34a the key to mesenchymal stem cell survival?
- Effect of saponins extracted from Panax japonicus on inhibiting cardiomyocyte apoptosis by AMPK/SIRT1/NF-κB signaling pathway in aging rats
- SIRT1 (sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae))
- Morphoproteomics identifies the EZH2 and SIRT1 pathways as potential blocks to differentiation in yolk sac tumor of the ovary and provides therapeutic options: A …
- Mechanism of action of the SIRT1-FoxO1-AdipoR2 signaling pathway in alcoholic fatty liver disease
- Cordyceps sinensis protects HK2 cells from ischemia-reperfusion injury through SIRT1 pathway
- Multi-allele dipstick assay for visual genotyping of four novel SIRT1 gene variant alleles as candidate biomarkers for sporadic Parkinson disease
- Corrigendum to” Restoration of SIRT1 Function by Pterostilbene Attenuates Hypoxia-Reoxygenation Injury in Cardiomyocytes”[Eur. J. Pharmacol. 776 (2016) 26-33]
- Expression of AMPK, SIRT1, and ACC differs between winter-and summer-acclimatized Djungarian Hamsters
- Construction of lentiviral vector containing SIRT1 gene and its expression in retinal ganglion cell
- Anti-inflammatory effect of Chikusetsu oleanane saponin on Raw264. 7 cell through regulating SIRT1 activity
- PPAR gamma coactivator 1 beta (PGC-1β) reduces mammalian target of rapamycin (mTOR) expression via a SIRT1-dependent mechanism in neurons
- Effect of SIRT1 gene silencing on radiosensitivity of diffuse large B-cell lymphoma cells
- AB0107 The modulation of macrophage polarization by SIRT1 maybe new target therapy in rheumatoid arthritis
- Effect of SIRT1 deficiency on function of brown adipose tissue in obese mice
- Role of SIRT1 in C5b-9 mediated oligodendrocyte cell cycle activation
- Survivin and SIRT1: can be two prognostic factors in chronic myeloid leukemia?
- Intratumoral heterogeneity for inactivating frameshift mutation of CUX1 and SIRT1 genes in gastric and colorectal cancers
- The Impact of Ramadan Fasting on SIRT1 mRNA Expression in Peripheral Blood Mononuclear Cells
- A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy …
- SIRT1 is downregulated during peripheral blood stem cell mobilization in healthy donors by granulocyte-colony stimulating factor
- 3 SIRT1—A POSSIBLE MARKER FOR REPRODUCTIVE AGING OF IN VIVO-DERIVED BOVINE OOCYTES?
- SIRT1 inhibited oxidized low-density lipoprotein induced smooth muscle cells inflammatory response
- Cardiac SIRT1 Has a Protective Role in Lipotoxic Cardiomyopathy through Maintaining Membrane Fatty Acid Composition
- Effect of Qinggan Zishen Chinese Medicine on SIRT1 Protein Expression in Liver Tissue of Spontaneously Hypertensive Rats Fed with High Fat Diet
- Roles of NAD in Protection of Axon against Degeneration via SIRT1 Pathways
- Allosteric SIRT1 activators as putative anti-aging drugs
- AB059. MiR-34a inhibits cell proliferation in prostate cancer by downregulation of SIRT1 expression
- SIRT1 Activator II Protects against Myocardial Injury in High Fat Diet‐Induced Diabetic Mice
- Analysis of silent information regulator 1 (SIRT1) gene polymorphisms in antituberculosis-drug-induced hepatotoxicity in a prospective cohort study
- D-4F decreases the expression of Aβ protein through up-regulating long non coding RNA SIRT1-as in SAMP8 mice
- Correction to The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD+) and an Indole (EX527 Analogue) …
- Myeloid cell-specific SIRT1 knockout impairs innate immune responses against intracellular bacteria infection
- Enhanced Targeting of FLT3-ITD+ AML Stem Cells through Combined Inhibition of SIRT1 and Autophagic Flux
- PI3 K/Akt/SIRT1 signaling pathway mediated hydrogen sulfide postconditioning-induced protection against I/R injury
- Myeloid deletion of SIRT1 suppresses collagen-induced arthritis in mice by modulating dendritic cell maturation
- SIRT1 modulates AID expression, class switch DNA recombination and somatic hypermutation by repressing NF-kB activity
- Effect of telmisartan and insulin on endoplasmic reticulum stress and the expression of SIRT1 in testis of type 1 diabetic rats
- Different patterns of SIRT1, KLF4, DAPK1 and SPG20 methylation in B lymphocytes correlate with the clinical parameters of non-Hodgkin lymphoma subtypes
- Hypermethylation of HIC1 and aberrant expression of HIC1/SIRT1 contribute to papillary thyroid carcinoma
- Corrigendum: transcriptional repression of SIRT1 by protein inhibitor of activated STAT 4 (PIAS4) in hepatic stellate cells contributes to liver fibrosis
- Effects of Chaihu Shugan powder on hepatic lipid metabolism and AMPK/SIRT1 pathway in rats with non-alcoholic fatty liver disease
- MP369 D PINITOL ALLEVIATES CYCLOSPORINE-INDUCED RENAL FIBROSIS VIA THE ACTIVATION OF SIRT1 AND NRF2 ANTIOXIDANT PATHWAYS
- SIRT1 modulates immunoglobulin class switch DNA recombination and somatic hypermutation by regulating B lymphocyte Aicda expression through NF-kB …
- Mir-217 promotes inflammation and fibrosis induced by high glucose in rat glomerular mesangial cells via SIRT1/HIF-1αsignal pathway
- Gaba-betaine modulates SIRT1 and p16INK4A expression during high-glucose induced endothelial cell senescence
- SIRT1 and tumor resistance
- ROLE OF SIRT1 IN CANCER: A REVIEW
- Silent mating-type information regulator 2 homolog 1 (SIRT1) in Alzheimer’s disease: an update on potential mechanisms
- Consecutive stimulation of HBsAg promotes the viability of the human B lymphoblastoid cell line IM‑9 through regulating the SIRT1‑NF‑κB pathway
- Dihydroartemisinin enhances antitumor effect of 5-fluorouracil against gastric cancer by down-regulating SIRT1 expression
- Synthesis of potential SIRT1 activators
- Baicalin treatment regulates hyperactivity of HPA axis and alters SIRT1 related inflammation in the hypothalamus in a model of depression
- … Angelica Sinensis Ameliorates High-Fat Diet and STZ-induced Hepatic Oxidative Stress and Inflammation in Diabetic Mice by Activating SIRT1-AMPK Pathway”[JNB 43 …
- E1231, an activator of SIRT1, regulates cholesterol and lipid metabolism through SIRT1-LXRALPHA-ABCA1 pathway
- The correlation between SIRT1 and Muller cells in the development of CNV
- The Role of SIRT1 in Muscle Hypertrophy
- Effect of SIRT1 on the proliferation of ovarian cancer CAOV3 cells and its possible mechanism
- GW28-e0071 The Effect of Mild Hypothermia on Neurons Autophagy after Cerebral Ischemia Reperfusion in SIRT1 Knockout Mice
- SIRT1 regulates Mxd1 throughout melanoma progression
- SIRT1 Increases the Expression of Fetal Hemoglobin Genes in Human Adult and Cord Blood Erythroblasts
- The role of SIRT1 in the formation of retinal miroaneurysms during aging
- MODULATION OF SIRT1 AS AN ANTI-AGEING TARGET
- The effect of shRNA interference lentivirus vector targeting rat SIRT1 gene on the expression of SIRT1 in retinal ganglion cell
- Combined Determination of Carbohydrate Antigen 199 and SIRT1 Based on an Electrochemiluminescence Immunosensor
- THE ROLE OF SIRT1 IN AGEING AND FRAILTY
- GW28-e0612 Liver X receptor agonist T0901317 ameliorates sepsis-induced myocardial injury and dysfunction: the role of SIRT1 signaling
- The Impact of Catalytically Inactive SIRT1 on Age-Associated Cardio-Renal Dysfunction
- P220 Depigmenting effect of resveratrol is not dependent on SIRT1 activation
- A role of SIRT1 in the Notch signalling pathway
- Salinomycin suppresses TGF-β1-induced EMT by down-regulating MMP-2, 9 via AMPK-SIRT1 pathway in a non-small cell lung cancer
- ASSOCIATION OF SIRT1 RS3740051 GENE POLYMORPHISM WITH PITUITARY ADENOMA
- Exploring cellular actions and interactions of SIRT1 that may counteract ageing
- SIRT1: Expression in the cornea and its role in corneal wound healing
- Expression Changes and Significance of SIRT1 Alternative Splicing Variants of SIRT1-Exon8 mRNA in the Hippocampus of Young and Aged Mice
- Effects of maternal lead exposure on expression of 8-OHd G and SIRT1 in brain tissue of mice offspring
- SIRT1 ACTIVATION IMPROVES HEART FUNCTION THROUGH INHIBITION OF INFLAMMATION IN CHAGAS DISEASE
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- Spatial Dynamics of SIRT1 Relates to Metabolic Transitions in the Cell Nucleus
- Assessment of SIRT1 gene expression in patients with chronic myeloid leukemia by real time pcr method
- Expression of SIRT1 in a Uveal Melanoma Animal Model
- The Role of SIRT1 In Breast Cancer Stem Cells
- Non-canonical activation of AR signaling by histone deacetylase SIRT1
- Computational model of circadian oscillator in mammals: Interaction with NAD+/SIRT1 system and age-related changes in the expression of circadian oscillator genes
- Influence of EGFR in B [a] P-induced SIRT1 activation in human bronchial epithelial cells
- SIRT1 and Age-Related Macular Degeneration
- SIRT1 activators induced neuroprotection of photoreceptors in rd10 mice
- The effect of SIRT1 inhibition by EX527 on uveal melanoma cells
- Association of SIRT1 rs3740051 gene polymorphism with pituitary adenoma
- Role of variants at SIRT1 gene in pituitary adenoma
- SIRT1 inhibition exhibits decreased pluripotency in cancer stem cells of glioma
- The effects of SIRT1 inhibitors nicotinamide and Ex-527 on lymphoma cells
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- Novel therapies for cancer treatment: designing high affinity selective ligands against SIRT1 enzyme
- Does SIRT1 or cytostasis underlie the anti-ageing activity of trans-stilbenes?
- SIRT1 in Trophoblast Differentiation and Placental Development
- THE ASSOCIATION BETWEEN SIRT1 RS3740051 AND AGE-RELATED MACULAR DEGENERATION
- Knockdown of SIRT1 enhances the sensitivity to cisplatin by inhibiting autophagy in A549 cells
- Effect of supplemental Erchen decoction on role of oxidative stress and SIRT1 in rats with chronic obstructive pulmonary disease
- NAD+-Dependent SIRT1 Reprograms CD11c+ Dendritic Cells and Cd4+ T Cells to Control Immune Polarity During Sepsis
- SIRT1 decreases TLR2-mediated Mac-1 expression in atherosclerosis
- Association of single nucleotide polymorphism of SIRT1 gene with age-related cataract
- Effect of SIRT1 on dynamic expression of AQP4 in early stage of cerebral ischemia in rats
- Spatial Dynamics of SIRT1 Dictate Metabolic Transitions in the Cell Nucleus
- SIRT1 plays a pivotal role in TLR2‐mediated Mac‐1 expression in monocytes
- SIRT1 Regulates the Inflammator\Response of Vascular Adventitial Fibroblasts through Autophag\and Related Signaling Pathwa\
- Persistent global inflammation caused by the loss of SIRT1 protects against experimental osteoarthritis
- Exploring the SIRT1/P53 Pathway in Adipocytes Hyperplasia
- Endothelial SIRT1 Is Required for PGC1α-Induced Angiogenesis in Skeletal Muscle Tissue
- The study of the inhibition effects of SIRT1 on the apoptosis induced by Galangin in HepG2 cells
- Relationship between mechanism of SIRT1-mediated mitophagy in myocardium and Mfn2 in diabetic rats
- SIRT1, 2, 3 protect mouse oocytes from postovulatory aging
- Regulation of IL-4 Gene Expression By SIRT1 in Human Mast Cell
- Aging-related change of erectile function and the expression of SIRT1
- SIRT1 was involved in TNF-α-promoted osteogenic differentiation of human DPSCs through Wnt/β-catenin signal Animal
- Interactions between SIRT1 and STAT3 in the retinal pigmented epithelium cell
- Endothelial-specific SIRT1 Deletion Inhibits Retinal Vascular Endothelial Cell Migration
- SIRT1 suppresses atherosclerosis induced by TLR2-mediated monocyte adhesion to endothelium through MAC-1 expression
- Serum SIRT1 level is higher in male patient with isolated hypogonadotropic hypogonadism: The first study in human
- SIRT1 negatively regulates the expression of Prl2C3, a senescence-associated protein
- The Association between SIRT1 rs3740051 and age-related macular degeneration
- SIRT1 Attenuates Nasal Polypogenesis By Suppressing Epithelial-to-Mesenchymal Transition
- Celastrol protects against fatty liver through SIRT1
- ROS Induced Mitochondrioal Dysfunction Causes Endothelial Dyfunction by Downregulation Of SIRT1
- Effects of Buyang Huanwu Decoction against oxidative stress of rBMECs by up-regulating SIRT1
- Correlation analysis of SIRT1 gene variant and susceptibility to chronic obstructive pulmonary disease
- SIRT1 Activity Is Required For The Protective Effects Of The Female Sex In The Response To Chronic Hypoxia
- Recurrent cigarette smoke exposure impairs SIRT1 shuttling in bronchial epithelial cells
- Effect of SIRT1 on the expression and phosphorylation of Tau protein in neuroblastoma SK-N-SH cells
- CAY10591, a SIRT1 Activator, Suppresses Malignancy of Gingival Epithelial Carcinoma Cells
- SIRT1 Maintains PGC-1α Function Through Periodic Promoter Release
- Endothelial SIRT1 as a drug target for vascular ageing-related diseases.
- ASSESSMENT OF SIRT1 GENE EXPRESSION IN PATIENTS WITH CHRONIC MYELOID LEUKEMIA BY REAL TIME PCR METHOD
- miR-199a-5p enhances expression of myocardial fibrosis-related genes by targeting SIRT1
- Role of SIRT1 in the adaptive response of mouse ovaries to radiotherapy (X ray radiations)
- Impact of expression of SIRT1 and SIRT2 on outcome in the very elderly patients with colorectal cancer.
- SIRT1 Regulates Acrosome Biogenesis by Modulating Autophagic Flux During Spermiogenesis in Mice
- Studies on the mechanism of SIRT1/AMPK signaling pathway between hepatocytes and hepatic stellate cells
- Resveratrol: An Epigenetic Regulator of SIRT1–Is It a Magic Tool to Prevent Cardiovascular Disease?
- Anti‐vascular ageing effects of endothelial SIRT1‐communicating with smooth muscle cells of the arteries
- Age-related structural changes in the liver of old mice with SIRT1 overexpression in conjunction with NMN supplementation
- SIRT1 rs7896005 polymorphism may be related to coronary artery disease in Caucasians with type 2 diabetes, without affecting all-cause mortality.
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- Oscillatory Gene Promoter Regulation by Pgc-1α and SIRT1 in Cardiac Energy Metabolism
- Effects of SIRT1 gene knockout on chronic kidney disease induced by 5/6 nephrectomy in mice and VEGF/Flk-1 signaling pathway
- Regulation of SIRT1 by SREBP-1 in Adipogenic Differentiation of Mesenchymal Stem Cells
- The role of SIRT1 in LPS-induced lung endothelial barrier dysfunction and lung injury in vivo
- SIRT1 protects against radiation-induced lung injury via de-acetylating the Ku70 and P65
- Decreased SIRT1 expression is related to bronchopulmonary dysplasia in premature infants after oxygen exposure
- SIRT1 overexpression inhibits tunicamycin-induced endoplasmic reticulum stress in chondrocytes
- Correction for Shah et al.,“A Deacetylase-Deficient SIRT1 Variant Opposes Full-Length SIRT1 in Regulating Tumor Suppressor p53 and Governs Expression of …
- Association of single nucleotide polymorphism of SIRT1 and APOC3 with nonalcoholic fatty liver disease
- Inhibition of CML Development Following Conditional SIRT1 Deletion in Transgenic BCR-ABL Mice
- SIRT1 expression is associated with formation of atherosclerotic plaques in diabetic patients
- ACTIVATION OF THE SIRT1-LXR SIGNALLING PATHWAY IN RETINAL PIGMENTED EPITHELIAL CELLS PROMOTES CHOLESTEROL METBOLISM
- SIRT1 inhibited oxidized low-density lipoprotein induced smooth muscle cells inflammatory response
- Effect of Helicobacter pylori infection on SIRT1 and Sirt2 gene expression in human gastritis samples
- Circulating SIRT1 Protects Against Atherosclerosis Through Its Modulation of Pcsk9 Activity
- Glycine decarboxylase inhibits proliferation of ovarian cancer cells via SIRT1-mediated apoptosis
- Glycolysis promotes MDSCs and cancer stemness through the interaction between SIRT1 and C/EBPb
- A clinical study on activity of NAMPT and SIRT1 gene expression in neutropenia with cancer chemotherapy.
- Effect of Vitamin E on the Expression of SIRT1 and PGC-1α in Mice with Nonalcoholic Fatty Liver Disease
- The evaluation of gene expression and enzyme activity of SIRT1 in peripheral blood mononuclear cells isolated from patients with relapsing-remitting multiple …
- Abstract WMP41: Neuronal SIRT1 is Required for Resveratrol Preconditioning Induced Ischemic Tolerance
- Effect Of Oral Appliance On Circulating Leukocyte Telomere Length And SIRT1 In Obstructive Sleep Apnea Syndrome
- Loss of the longevity gene SIRT1 dysregulates chondrocytes and leads to an arthritic phenotype in vivo, via impaired autophagy
- Observation of the articular cartilage of osteoarthritis in SIRT1 gene knock-out mice through single staining and compound staining
- Alleviation of inflammation in human RPE cells by bromodomain inhibitors is independent of SIRT1
- Monomethylfumarate induces NAD+ and SIRT1 in Human Retinal Pigment Epithelial Cells: Relevance to Development of New Therapies for Dry AMD
- Non-invasive molecular imaging of SIRT1-mediated epigenetic regulation in cancer using PET/CT with a novel substrate-type radiotracer 2-[18F] PhAHA
- Adiponectin promotes normal human epidermal keratinocyte differentiation and calcium influx via SIRT1
- Myeloid deletion of SIRT1 suppresses collagen-induced arthritis in mice by modulatingdendritic cell maturation
- Cardiomyocyte SIRT1 Deficiency Alters Cardiac Substrate Metabolism and Sensitizes Myocardium to Ischemic Insults
- The relationship between serum SIRT1 and EGR1 and other inflammatory cytokines in type 2 diabetic patients with different stages of diabetic nephropathy
- D57 DON’T BE A DO-BADDER: NEW INTERVENTIONS FOR OSA: Effects Of Nasal Cpap On Exhaled SIRT1 And Tumor Necrosis Factor-[alpha] In Patients With …
- Computational Modeling of Calorie Restriction (CR) Mimetics for Age-Related Diseases: Ligands of SIRT1 Target.
- SIRT1 mediates the actions of PPARδ on the oxLDL-triggered migration and proliferation of vascular smooth muscle cells
- Downregulation of the SIRT1 and Liver X Receptor α/β signaling axis promotes diabetic retinopathy pathogenesis
- Down-Regulation of Erk and SIRT1 Signaling May Lead to Reduced Fgf-21 Sensitivity in a Mouse Model of Diabetes
- … to “Rehabilitation Training and Resveratrol Improve the Recovery of Neurological and Motor Function in Rats after Cerebral Ischemic Injury through the SIRT1 …
- Hydrogen sulfide attenuates chronic restrain stress-induced cognitive impairment by upreglulation of hippocampal SIRT1
- SIRT1 reduction is associated with sex-specific dysregulation of renal lipid metabolism and stress responses in offspring by maternal high-fat diet
- Anti-tumor effects of metformin: Effects of metformin on SIRT1, Nrf2 and AhR expression in cancer cells
- Inhibition of p53 with its specific inhibitor pifithrin‐α prevents hepatic oxidative stress and inflammation, probably via up‐regulating SIRT1/Nrf2 pathway
- SIRT1 regulates low oxygen induced bovine granulosa cell proliferation through interaction with VEGF-AKT-mTOR pathway
- Computational model for mammalian circadian oscillator: interacting with NAD+/SIRT1 pathway and age-related changes in gene expression of circadian oscillator
- Immunoprecipitation of SIRT1, sirt3 and PGC-1A from rat gastrocnemius and soleus with magnetic beads
- TET2 Activity Is Modulated By SIRT1-Mediated Protein Deacetylation: A Potential Therapeutic Target in Myelodysplastic Syndrome
- Caloric Restriction Increases the Resistance of Aged Heart to Myocardial Ischemia/Reperfusion Injury via Modulating AMPK-SIRT1 Signaling Pathway
- Cardiomyocyte Specific Deletion of SIRT1 Gene Alters Substrate Metabolism and Sensitizes Myocardium to Ischemia and Reperfusion Injury
- SIRT1 Enhances Oxidized Low-density Lipoprotein Induced Autophagy in Human Valve Interstitial Cells
- EFFECT OF HELICOBACTER PYLORI INFECTION ON SIRT1 AND SIRT2 GENE EXPRESSION IN HUMAN GASTRITIS SAMPLES
- Role of SIRT1/FoxO3α signaling pathway in berberine pretreatment-induced reduction of hypoxia/reoxygenation-caused injury to hepatic parenchymal cells
- Oligonol Induces the Expression of the Anti-aging Molecule, SIRT1, via the AMPK-Autophagy Pathway
- GW27-e0410 Effect of astaxanthin intervention on contrast induced acute kidney injury through the SIRT1/FOXO3a signal
- SIRT1 Deacetylase Mediates Klotho Gene Deficiency-induced Arterial Remodeling and Stiffness
- Platycodin D (PD) attenuates myocardial apoptosis mediated by JNK-SIRT1-HSF1-IGF-IIR-Caspase-3 signaling in hypertensive conditions
- Activation of SIRT1 Attenuates Klotho Deficiency‐induced Arterial Stiffness and Hypertension via Enhancing AMPKα and eNOS activity
- Activation of SIRT1 Deacetylase Attenuates Klotho Deficiency-induced Arterial Stiffness and Hypertension
- … ] CALORIC RESTRICTION CAN IMPROVE LEARNING AND MEMORY OF C57/BL MICE PROBABLY VIA REGULATION OF THE SIRT1/AMPK SIGNALING PATHWAY
- Oxidative Stress-Induced Mir-200c Disrupts SIRT1, Foxo1 and Enos Regulatory Loop, Causing Endothelial Dysfunction and Oxidative Stress Increase
- The non-flavonoid polyphenol resveratrol induces anti-obesity effects via SIRT1 dependent improved mitochondrial functioning
- Role of Autophagy Inhibition in Regulating Hepatic Lipid Metabolism: Molecular Cross Talk Between Proteasome Activator REGγ and SIRT1 Signaling
- Associations of SIRT1 rs12778366, FGFR2 rs2981582 and STAT3 rs744166 polymorphisms with early age-related macular degeneration development
- HGF and bFGF Secretion by Human Adipose-derived Stem cells improve Ovarian Function of Natural Aging through Activation of SIRT1-FOXO1 Signaling Pathway
- Tongluo Xingnao Effervescent Tablets ameliorates cognitive function of SAMP8 mice via Nampt/SIRT1/FOXO3 pathway
- TM4SF1 regulates cell cycle and ROS status in bladder cancer cells by targeting FOXO3a via PPARγ-SIRT1 negative feedback loop
- RGS2 and SIRT1 Link Renin Angiotensin Aldosterone System to Alzheimer’s Disease
- Hypermethylation of HIC1 and aberrant expression of HIC1/SIRT1 contribute to papillary thyroid carcinoma
- SIRT1 facilitates initial recruitment of primordial follicles through activating mTOR and AKT transcription
- SIRT1 represses PKC-zeta activation via regulating its acetylation and phosphorylation modification in cardiac hypertrophy
- Effect of SIRT1/nf-κb signal axis on delaying hematopoietic stem cell and progenitor cell senescence with ginsenoside r1 in aging model rat induced by d-galactose
- 100 SIRT1 Activation: A Strategy for Harnessing Endogenous Protection Against SAH-induced Neurovascular Dysfunction
- miR-34a augments immune response through triggering NF-κB/B7-H3/TNF-α feedforward loop via SIRT1 in colorectal carcinoma
- Gallotannin induces senescence and autophagy leading to cell death via SIRT1 inhibition and AMPK activation in hepatocellular carcinoma cells
- Myocardial Senescence Induced by Inactivation Aldh2-SIRT1-GATA4 Pathway Involves in Heart Remolding After Acute Infarction
- Inhibition of glycolysis abolishes microglial inflammatory activation via suppression of TBK1/NF-κB and HIF1α/SIRT1/p65 acetylation
- SIRT1 Inhibitor Enhances Hsp90 Inhibitor-mediated Abrogation of Hsp90 Chaperone Function and Potentiates the Cytotoxicity of Hsp90 Inhibitor in Chemo-resistant …
- Mir-217 promotes inflammation and fibrosis induced by high glucose in rat glomerular mesangial cells via SIRT1/HIF-1α signal pathway
- miR-21 Regulates TNF-α-Induced CD40 Expression via SIRT1-NF-κB Pathway in Renal Inner Medulla Collecting Duct Cells
- PS 07-12 UPREGULATED SGLT2 REDUCES PROXIMAL TUBULAR SIRT1 AND AUGMENTS RENAL GLUCONEOGENESIS IN EARLY STAGE DIABETIC …
- Muscle Through SIRT1-Dependent Mechanisms Thomas K. Sin, Bjorn T. Tam, Angus P. Yu, Shea P. Yip, Benjamin Y. Yung, Lawrence W. Chan, Cesar S. Wong, John …
- Abstract P2-03-06: Dysregulation of miR-34a-SIRT1 axis reduced breast cancer stemness
- Deciphering the PACS-2–SIRT1 interaction site and its relevance in vivo
- MMP-9, HIF-1 and SIRT1 in acute lung injury: a review
- MiR-486 Regulates the Glycometabolism of Hematopoietic Cells by Targeting SIRT1
- EP-2041: Vitamin D protects HUVEC from RT-induced senescence and apoptosis by modulating MAPK/SIRT1 axis
- MicroRNA-9 represses sirtuin 1 (SIRT1) in human keratinocytes
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- Association of serum Mir-217 level with SIRT1 and HIF-1αin type 2 diabetic patients with different urinary albumin excretion rates
- Functional Link Between Heat Shock Protein HSP90alpha and Sirtuin 1 (SIRT1) in the Pathogenesis of Diffuse Large B Cell Lymphoma
- THE EFFECT OF 10 WEEKS OF HIGH INTENSITY INTERVAL TRAINING AND GREEN TEA SUPPLEMENTS ON SERUM LEVELS OF SIRT1 AND PGC-1? IN …
- The effect of 10 weeks of high intensity interval training and green tea supplements on serum levels of SIRT1 and PGC-1α in overweight women
- MicroRNA-34a promotes apoptosis of human lens epithelial cells through down-regulation of Bcl-2 and SIRT1
- 3D-QSAR modeling and analysis of Thieno [3, 2-d] pyrimidine-6-carboxamides as potent SIRT1-3 inhibitors
- Abstract P141: GYY4137, a H2S Donor, Normalizes miR-132 Targeted SIRT1 and Ace2 Expression to Improve Kidney Function in Hypertension
- Relationship between microRNA-369-3p, SIRT1, and IL-22 in psoriasis vulgaris
- PS 04-13 CR6-INTERACTING FACTOR 1 DEFICIENCY IMPAIRS VASCULAR FUNCTION BY INHIBITING THE SIRT1-eNOS PATHWAY
- Effects of microRNA-33-agonist and-antagonist on AMPK, SIRT1 & SREBP-2 expression in AMPK-SIRT1 pathway in mice liver
- F-72 Salinomycin suppresses TGF-β1-induced EMT by down-regulating MMP-2, 9 via AMPK-SIRT1 pathway in a non-small cell lung cancer
- Allosteric SIRT1 activators as putative anti-aging drugs
- The role of SIRT1 in diabetic retinopathy
- SIRT1: a guardian of the development of diabetic retinopathy
- Role and possible mechanisms of SIRT1 in depression
- SIRT1 and HIF1α signaling in metabolism and immune responses
- SIRT1 and SIRT6 signaling pathways in cardiovascular disease protection
- Computational and experimental insights into the circadian effects of SIRT1
- SIRT1 as a therapeutic target in diabetic complications
- Brain SIRT1 mediates metabolic homeostasis and neuroprotection
- SIRT1 antisense long noncoding RNA promotes cardiomyocyte proliferation by enhancing the stability of SIRT1
- Metformin is a direct SIRT1-activating compound: computational modeling and experimental validation
- The role of SIRT1 in ischemic stroke: pathogenesis and therapeutic strategies
- SIRT1 deacetylates tau and reduces pathogenic tau spread in a mouse model of tauopathy
- SIRT1 promotes formation of breast cancer through modulating Akt activity
- SIRT1 and microRNAs: The role in breast, lung and prostate cancers
- SIRT1 is a potential drug target for treatment of diabetic kidney disease
- High levels of SIRT1 expression as a protective mechanism against disease-related conditions
- Resveratrol boosts cognitive function by targeting SIRT1
- An in vitro comparative study of the antioxidant activity and SIRT1 modulation of natural compounds
- The essential role of SIRT1 in hypothalamic-pituitary axis
- A SIRT1-centered circuitry regulates breast cancer stemness and metastasis
- SIRT1 in secretory organ cancer
- Effects of resveratrol and other polyphenols on SIRT1: relevance to brain function during aging
- SIRT1-Sirt3 axis regulates human blood-brain barrier permeability in response to ischemia
- SLAB51 probiotic formulation activates SIRT1 pathway promoting antioxidant and neuroprotective effects in an AD mouse model
- The interplay of SIRT1 and Wnt signaling in vascular calcification
- Cervical cancer is addicted to SIRT1 disarming the AIM2 antiviral defense
- Resveratrol modulates SIRT1 and DNMT functions and restores LINE-1 methylation levels in ARPE-19 cells under oxidative stress and inflammation
- SIRT1 suppresses the migration and invasion of gastric cancer by regulating ARHGAP5 expression
- Reduced expression of SIRT1 and SOD-1 and the correlation between these levels in various regions of the brains of patients with Alzheimer’s disease
- SIRT1 controls acetaminophen hepatotoxicity by modulating inflammation and oxidative stress
- Regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular signaling pathways involving ‘SIRT1 and PGC-1α’
- SIRT1, miR-132 and miR-212 link human longevity to Alzheimer’s Disease
- Narrower insight to SIRT1 role in cancer: A potential therapeutic target to control epithelial–mesenchymal transition in cancer cells
- Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1
- Cardiomyocyte-specific deletion of SIRT1 gene sensitizes myocardium to ischaemia and reperfusion injury
- SIRT1 mediates obesity-and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression
- SIRT1 attenuates murine allergic rhinitis by downregulated HMGB 1/TLR4 pathway
- SIRT1 antagonizes liver fibrosis by blocking hepatic stellate cell activation in mice
- SIRT1 induces epithelial-mesenchymal transition by promoting autophagic degradation of E-cadherin in melanoma cells
- SIRT1 activation disrupts maintenance of myelodysplastic syndrome stem and progenitor cells by restoring TET2 function
- LncRNA ANRIL regulates AML development through modulating the glucose metabolism pathway of AdipoR1/AMPK/SIRT1
- SIRT1 and estrogen signaling cooperation for breast cancer onset and progression
- SIRT1 regulates inflammation response of macrophages in sepsis mediated by long noncoding RNA
- Cerebroprotection by salvianolic acid B after experimental subarachnoid hemorrhage occurs via Nrf2-and SIRT1-dependent pathways
- CTRP3 protected against doxorubicin-induced cardiac dysfunction, inflammation and cell death via activation of SIRT1
- Histone deacetylase SIRT1 targets Plk2 to regulate centriole duplication
- Promotion of SIRT1 protein degradation and lower SIRT1 gene expression via reactive oxygen species is involved in Sb-induced apoptosis in BEAS-2b cells
- Breaking down the contradictory roles of histone deacetylase SIRT1 in human breast cancer
- SIRT1/PGC-1α signaling promotes mitochondrial functional recovery and reduces apoptosis after intracerebral hemorrhage in rats
- Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK/SIRT1 signaling pathway in OA rats
- Chlorogenic acid protects against oxLDL‐induced oxidative damage and mitochondrial dysfunction by modulating SIRT1 in endothelial cells
- Chronic exposure to low dose of bisphenol A impacts on the first round of spermatogenesis via SIRT1 modulation
- SIRT1 regulates nuclear number and domain size in skeletal muscle fibers
- Acute downregulation of miR-199a attenuates sepsis-induced acute lung injury by targeting SIRT1
- Geniposide protects against obesity-related cardiac injury through AMPKα-and SIRT1-dependent mechanisms
- Resveratrol pretreatment attenuates traumatic brain injury in rats by suppressing NLRP3 inflammasome activation via SIRT1
- SIRT1 reverses senescence via enhancing autophagy and attenuates oxidative stress-induced apoptosis through promoting p53 degradation
- Effects of Ginsenoside Rg3 on fatigue resistance and SIRT1 in aged rats
- SIRT1 acts as a potential tumor suppressor in oral squamous cell carcinoma
- Cardioprotection of CAPE-oNO2 against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and …
- Resveratrol improves glucose uptake in insulin-resistant adipocytes via SIRT1
- LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/SIRT1/HIF-1α signaling
- MiR-29a suppresses cell proliferation by targeting SIRT1 in hepatocellular carcinoma
- H2S to Mitigate Vascular Aging: a SIRT1 connection
- Inflammatory cytokines and SIRT1 levels in subcutaneous abdominal fat: relationship with cardiac performance in overweight pre-diabetics patients
- Oxidative stress induces imbalance of adipogenic/osteoblastic lineage commitment in mesenchymal stem cells through decreasing SIRT1 functions
- Yap regulates gastric cancer survival and migration via SIRT1/Mfn2/mitophagy
- Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1β in rats with COPD
- Buyang Huanwu decoction targets SIRT1/VEGF pathway to promote angiogenesis after cerebral ischemia/reperfusion injury
- Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SIRT1/PGC-1α/mitochondrial biosynthesis pathway
- MiR-29b reverses oxaliplatin-resistance in colorectal cancer by targeting SIRT1
- Disruption of the circadian clock alters antioxidative defense via the SIRT1-BMAL1 pathway in 6-OHDA-induced models of Parkinson’s disease
- Metformin overcomes high glucose-induced insulin resistance of podocytes by pleiotropic effects on SIRT1 and AMPK
- SIRT1/Nrf2 pathway is involved in oocyte aging by regulating Cyclin B1
- Overexpression of SIRT1 in mesenchymal stem cells protects against bone loss in mice by FOXO3a deacetylation and oxidative stress inhibition
- Influence of SIRT1 polymorphisms for diabetic foot susceptibility and severity
- Resveratrol, an activator of SIRT1, induces protective autophagy in non-small-cell lung cancer via inhibiting Akt/mTOR and activating p38-MAPK
- SIRT1 inhibits rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and inflammatory response via suppressing NF-κB pathway
- Mitochondrial fission is required for angiotensin II-induced cardiomyocyte apoptosis mediated by a SIRT1-p53 signaling pathway
- The dynamic shuttling of SIRT1 between cytoplasm and nuclei in bronchial epithelial cells by single and repeated cigarette smoke exposure
- miR-133b and miR-199b knockdown attenuate TGF-β1-induced epithelial to mesenchymal transition and renal fibrosis by targeting SIRT1 in diabetic nephropathy
- Exercise training augments SIRT1-signaling and attenuates cardiac inflammation in D-galactose induced-aging rats
- Resveratrol ameliorates lipid droplet accumulation in liver through a SIRT1/ATF6-dependent mechanism
- Targeting estrogen receptor beta (ERβ) for treatment of ovarian cancer: importance of KDM6B and SIRT1 for ERβ expression and functionality
- Transcriptional regulation of metabolism by SIRT1 and SIRT7
- Thymoquinone attenuates myocardial ischemia/reperfusion injury through activation of SIRT1 signaling
- Reduction of SIRT1 epigenetically upregulates NALP1 expression and contributes to neuropathic pain induced by chemotherapeutic drug bortezomib
- Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice
- NAMPT is a potent oncogene in colon cancer progression that modulates cancer stem cell properties and resistance to therapy through SIRT1 and PARP
- SIRT1 overexpression is an independent prognosticator for patients with esophageal squamous cell carcinoma
- Phenolic plant extracts induce SIRT1 activity and increase antioxidant levels in the rabbit’s heart and liver
- Dioscin alleviates non-alcoholic fatty liver disease through adjusting lipid metabolism via SIRT1/AMPK signaling pathway
- miR-30a suppresses lung cancer progression by targeting SIRT1
- Mounting evidence validates Ursolic Acid directly activates SIRT1: A powerful STAC which mimic endogenous activator of SIRT1
- High-fat diet mediates anxiolytic-like behaviors in a time-dependent manner through the regulation of SIRT1 in the brain
- Regulation of apoptosis and radiation sensitization in lung cancer cells via the SIRT1/NF-κB/Smac pathway
- SIRT1 protects from K‐Ras‐driven lung carcinogenesis
- SIRT1-dependent epigenetic regulation of H3 and H4 histone acetylation in human breast cancer
- … myocardial ischemia/reperfusion injury in type 1 diabetic rats by reducing oxidative stress and apoptosis through activating the SIRT1-Nrf2 signaling pathway
- Baicalin regulates SIRT1/STAT3 pathway and restrains excessive hepatic glucose production
- SIRT1 protects against oxidative stress-induced apoptosis in fibroblasts from psoriatic patients: A new insight into the pathogenetic mechanisms of psoriasis
- Fluoride induces apoptosis via inhibiting SIRT1 activity to activate mitochondrial p53 pathway in human neuroblastoma SH-SY5Y cells
- SIRT1 alleviates LPS induced inflammation of periodontal ligament fibroblasts via downregulation of TLR4
- Mechanical stretch induces antioxidant responses and osteogenic differentiation in human mesenchymal stem cells through activation of the AMPK-SIRT1 signaling …
- Acetylation-dependent regulation of Notch signaling in macrophages by SIRT1 affects sepsis development
- PARP-1 inhibition protects the diabetic heart through activation of SIRT1-PGC-1α axis
- MiRNA-200a induce cell apoptosis in renal cell carcinoma by directly targeting SIRT1
- High glucose up-regulates microRNA-34a-5p to aggravate fibrosis by targeting SIRT1 in HK-2 cells
- The IRF9-SIRT1-P53 axis is involved in the growth of human acute myeloid leukemia
- Icariin, a flavonoid with anti-cancer effects, alleviated paclitaxel-induced neuropathic pain in a SIRT1-dependent manner
- Ube2v1-mediated ubiquitination and degradation of SIRT1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy
- SIRT1 facilitates amyloid beta peptide degradation by upregulating lysosome number in primary astrocytes
- Resveratrol suppresses rotenone‐induced neurotoxicity through activation of SIRT1/Akt1 signaling pathway
- Melatonin attenuates postovulatory oocyte dysfunction by regulating SIRT1 expression
- Intraperitoneal injection of the SIRT1 activator SRT1720 attenuates the progression of experimental osteoarthritis in mice
- SIRT1 increases cardiomyocyte binucleation in the heart development
- A p300 and SIRT1 regulated acetylation switch of C/EBPα controls mitochondrial function
- An insulin-responsive sensor in the SIRT1 disordered region binds DBC1 and PACS-2 to control enzyme activity
- Liraglutide repairs the infarcted heart: The role of the SIRT1/Parkin/mitophagy pathway
- Chronic silymarin, quercetin and naringenin treatments increase monoamines synthesis and hippocampal SIRT1 levels improving cognition in aged rats
- Hypothalamic SIRT1 protects terminal Schwann cells and neuromuscular junctions from age‐related morphological changes
- miR-34a promotes vascular smooth muscle cell calcification by downregulating SIRT1 (Sirtuin 1) and Axl (AXL Receptor Tyrosine Kinase)
- Dioscin protects against coronary heart disease by reducing oxidative stress and inflammation via SIRT1/Nrf2 and p38 MAPK pathways
- Resveratrol reduces senescence-associated secretory phenotype by SIRT1/NF-κB pathway in gut of the annual fish Nothobranchius guentheri
- Novel SIRT1 inhibitor 15-deoxy-Δ12, 14-prostaglandin J2 and its derivatives exhibit anticancer activity through apoptotic or autophagic cell death pathways in …
- Low molecular weight fucoidan attenuates liver injury via SIRT1/AMPK/PGC1α axis in db/db mice
- Long-term l-serine administration reduces food intake and improves oxidative stress and SIRT1/NFκB signaling in the hypothalamus of aging mice
- Physical exercise improves aging-related changes in angiotensin, IGF-1, SIRT1, SIRT3, and VEGF in the Substantia Nigra
- SIRT1 deacetylase in aging‐induced neuromuscular degeneration and amyotrophic lateral sclerosis
- Moderate exercise suppresses NF-κB signaling and activates the SIRT1-AMPK-PGC1α axis to attenuate muscle loss in diabetic db/db mice
- Resveratrol prevents cognitive deficits induced by chronic unpredictable mild stress: SIRT1/miR-134 signalling pathway regulates CREB/BDNF expression in …
- Perturbations in the p53/miR-34a/SIRT1 pathway in the R6/2 Huntington’s disease model
- Spontaneous up‐regulation of SIRT1 during osteogenesis contributes to stem cells’ resistance to oxidative stress
- Paeonol ameliorates diabetic renal fibrosis through promoting the activation of the Nrf2/ARE pathway via up-regulating SIRT1
- Mouse macrophage specific knockout of SIRT1 influences macrophage polarization and promotes angiotensin II-induced abdominal aortic aneurysm formation
- SIRT1 activity in peripheral blood mononuclear cells correlates with altered lung function in patients with chronic obstructive pulmonary disease
- Inverse association of circulating SIRT1 and adiposity: a study on underweight, normal weight, and obese patients
- Paeonol alleviated acute alcohol-induced liver injury via SIRT1/Nrf2/NF-κB signaling pathway
- Anti-obesity effects of Spirulina maxima in high fat diet induced obese rats via the activation of AMPK pathway and SIRT1
- SIRT1 activation with neuroheal is neuroprotective but SIRT2 inhibition with AK7 is detrimental for disconnected motoneurons
- Berberine Improves Diabetic Encephalopathy Through the SIRT1/ER Stress Pathway in db/db Mice
- PARP1 inhibitor (PJ34) improves the function of aging-induced endothelial progenitor cells by preserving intracellular NAD+ levels and increasing SIRT1 …
- Homocysteine causes dysfunction of chondrocytes and oxidative stress through repression of SIRT1/AMPK pathway: A possible link between …
- Arginine promotes skeletal muscle fiber type transformation from fast-twitch to slow-twitch via SIRT1/AMPK pathway
- SIRT1 is a transcriptional enhancer of the glucocorticoid receptor acting independently to its deacetylase activity
- Flavonones from Penthorum chinense ameliorate hepatic steatosis by activating the SIRT1/AMPK pathway in HepG2 cells
- SIRT1: A novel way to target tau?
- 18β-Glycyrrhetinic acid protects against alpha-naphthylisothiocyanate-induced cholestasis through activation of the SIRT1/FXR signaling pathway
- ALDH2 attenuates early-stage STZ-induced aged diabetic rats retinas damage via SIRT1/Nrf2 pathway
- FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via SIRT1/AMPK/β1-integrin pathway
- Tangshen formula improves inflammation in renal tissue of diabetic nephropathy through SIRT1/NF-κB pathway
- Fisetin protects against hepatic steatosis through regulation of the SIRT1/AMPK and fatty acid β-oxidation signaling pathway in high-fat diet-induced obese mice
- Enhanced articular cartilage regeneration with SIRT1-activated MSCs using gelatin-based hydrogel
- Novel SIRT1 activator MHY2233 improves glucose tolerance and reduces hepatic lipid accumulation in db/db mice
- Liraglutide attenuates NLRP3 inflammasome-dependent pyroptosis via regulating SIRT1/NOX4/ROS pathway in H9c2 cells
- SIRT1 inhibits TGF‐β‐induced endothelial‐mesenchymal transition in human endothelial cells with Smad4 deacetylation
- Exercise intervention attenuates hyperhomocysteinemia-induced aortic endothelial oxidative injury by regulating SIRT1 through mitigating NADPH oxidase …
- Upregulation of SIRT1 inhibits H2O2‑induced osteoblast apoptosis via FoxO1/β‑catenin pathway
- Tomato powder inhibits hepatic steatosis and inflammation potentially through restoring SIRT1 activity and adiponectin function independent of carotenoid cleavage …
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