Aging is the main risk factor for many chronic degenerative diseases and cancer. Increased senescent cell burden in various tissues is a major contributor to aging and age-related diseases. Recently, a new class of drugs termed senolytics were demonstrated to extending healthspan, reducing frailty and improving stem cell function in multiple murine models of aging. To identify novel and more optimal senotherapeutic drugs and combinations, we established a senescence associated β-galactosidase assay as a screening platform to rapidly identify drugs that specifically affect senescent cells. We used primary Ercc1 −/− murine embryonic fibroblasts with reduced DNA repair capacity, which senesce rapidly if grown at atmospheric oxygen. This platform was used to screen a small library of compounds that regulate autophagy, identifying two inhibitors of the HSP90 chaperone family as having significant senolytic activity in mouse and human cells. Treatment of Ercc1 −/∆ mice, a mouse model of a human progeroid syndrome, with the HSP90 inhibitor 17-DMAG extended healthspan, delayed the onset of several age-related symptoms and reduced p16INK4a expression. These results demonstrate the utility of our screening platform to identify senotherapeutic agents as well as identified HSP90 inhibitors as a promising new class of senolytic drugs.
P53
January 4, 2020
TELOMERE SHORTENING & PREMATURE AGING
January 7, 2020Hsp90 (heat shock protein 90) is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against heat stress, and aids in protein degradation. It also stabilizes a number of proteins required for tumor growth, which is why Hsp90 inhibitors are investigated as anti-cancer drugs.
Heat shock proteins, as a class, are among the most highly expressed cellular proteins across all species.[3] As their name implies, heat shock proteins protect cells when stressed by elevated temperatures. They account for 1–2% of total protein in unstressed cells. However, when cells are heated, the fraction of heat shock proteins increases to 4–6% of cellular proteins.[4]
Heat shock protein 90 (Hsp90) is one of the most common of the heat-related proteins. The “90” comes from the fact that it weighs roughly 90 kiloDaltons. A 90 kDa protein is considered fairly large for a non-fibrous protein. Hsp90 is found in bacteria and all branches of eukarya, but it is apparently absent in archaea.[5] Whereas cytoplasmic Hsp90 is essential for viability under all conditions in eukaryotes, the bacterial homologue HtpG is dispensable under non-heat stress conditions.[6]
This protein was first isolated by extracting proteins from cells stressed by heating, dehydrating or by other means, all of which caused the cell’s proteins to begin to denature.[7] However it was later discovered that Hsp90 also has essential functions in unstressed cells. -wiki
SCIENTIFIC STUDIES
- Combinatorial attack on multistep oncogenesis by inhibiting the Hsp90 molecular chaperone
- Inhibiting the Hsp90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression
- Inhibiting Hsp90 to treat cancer: a strategy in evolution
- Molecular simulation of HER2/neu degradation by inhibiting HSP90
- Inhibiting the Hsp90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease
- Black tea polyphenols induce human leukemic cell cycle arrest by inhibiting Akt signaling: Possible involvement of Hsp90, Wnt/β‐catenin signaling and FOXO1
- Microparticles from patients with the acute coronary syndrome impair vasodilatation by inhibiting the Akt/eNOS-Hsp90 signaling pathway
- Cks1 proteasomal degradation is induced by inhibiting Hsp90-mediated chaperoning in cancer cells
- Inhibiting the molecular evolution of cancer through HSP90
- A chemical compound inhibiting the Aha1–Hsp90 chaperone complex
- Hsp90 is a novel target molecule of CDDO-Me in inhibiting proliferation of ovarian cancer cells
- Inhibiting heat shock protein 90 (Hsp90) limits the formation of liver cysts induced by conditional deletion of Pkd1 in mice
- Inhibiting Hsp90 prevents the induction of myeloid-derived suppressor cells by melanoma cells
- 3-O-(Z)-coumaroyloleanolic acid overcomes Cks1b-induced chemoresistance in lung cancer by inhibiting Hsp90 and MEK pathways
- Uncaria rhynchophylla Ameliorates Parkinson’s Disease by Inhibiting Hsp90 Expression: Insights from Quantitative Proteomics
- Targeting Hsp90-Cdc37: a promising therapeutic strategy by inhibiting Hsp90 chaperone function
- Combination Immunotherapy of Melanoma by inhibiting Hsp90 and targeting its client proteins.(TUM7P. 934)
- Influence of co-inhibiting mTORC2 and Hsp90 on proliferation apoptosis of multiple myeloma cells
- Hsp90 inhibiting anti-cancer therapeutics enhance bone loss by increasing osteoclast formation: Mechanism of action.
- Abstract# 1854: Superoxide-dependent hepatotoxicity of the Hsp90 inhibiting anticancer drugs geldanamycin and its two derivatives
- Development of Small Molecules Blocking Glucose Transporter Or Inhibiting Hsp90 for the Therapy of Cancer
- Gambogic acid attenuates liver fibrosis by inhibiting the PI3K/AKT and MAPK signaling pathways via inhibiting HSP90
- Ritonavir inhibits breast cancer cell proliferation, in part, by inhibiting Hsp90 function and Akt phosphorylation
- The effect of curcumin on bortezomib by inhibiting Hsp90 of myeloma MM1. R
- Diosgenin suppressed LPS-induced inflammation through inhibiting Hsp90 induced phosphorylation of NF-κb p65
- Inhibiting protein-protein interactions of Hsp90 as a novel approach for targeting cancer
- Inhibiting protein-protein interactions in Hsp90 dimerization as a novel approach for targeting cancer
- Characterization of celastrol to inhibit Hsp90 and cdc37 interaction
- Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase
- Synthesis and evaluation of coumermycin A1 analogues that inhibit the Hsp90 protein folding machinery
- Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to inhibit glioblastoma by geldanamycin
- Structure-activity relationship (SAR) of withanolides to inhibit Hsp90 for its activity in pancreatic cancer cells
- Disruption of the Bcr-Abl/Hsp90 protein complex: a possible mechanism to inhibit Bcr-Abl-positive human leukemic blasts by novobiocin
- Hsp90 blockers inhibit adipocyte differentiation and fat mass accumulation
- Cyclic lipopeptide antibiotics bind to the N-terminal domain of the prokaryotic Hsp90 to inhibit the chaperone activity
- New, Non‐quinone Fluorogeldanamycin Derivatives Strongly Inhibit Hsp90
- Ca2+/S100 proteins inhibit the interaction of FKBP38 with Bcl-2 and Hsp90
- 2D-QSAR of purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells
- Discovery of 18β-glycyrrhetinic acid conjugated aminobenzothiazole derivatives as Hsp90-Cdc37 interaction disruptors that inhibit cell migration and reverse drug …
- Single-walled carbon nanotubes (SWCNTs) inhibit heat shock protein 90 (Hsp90) signaling in human lung fibroblasts and keratinocytes
- Sarqaquinoic acid and related synthetic naphthoquinones inhibit the function of Hsp90
- Deguelin analogues, L80 and SH-1242, inhibit Hsp90 activity and exert potent anticancer efficacy with limited toxicities in non-small cell lung cancer (NSCLC)
- Abstract B80: Hsp90 inhibitor SNX‐2112 and prodrug SNX‐5422 (PF‐04929113) inhibit key signal pathways Akt, Src and STAT3 and reactivate tumor suppressor …http://mct.aacrjournals.org/
content/8/12_Supplement/B80. short - Hsp90 inhibition decreases mitochondrial protein turnover
- Hsp90 inhibition depletes Chk1 and sensitizes tumor cells to replication stress
- Engineered biosynthesis of geldanamycin analogs for Hsp90 inhibition
- Inhibition of Hsp90: a multitarget approach to radiosensitization
- Hsp90 inhibition results in autophagy-mediated proteasome-independent degradation of IκB kinase (IKK)
- Hsp90 inhibition is effective in breast cancer: a phase II trial of tanespimycin (17-AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer …
- Hsp90 inhibition: two-pronged exploitation of cancer dependencies
- 17 AAG for Hsp90 inhibition in cancer-from bench to bedside
- Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent Akt and Erk activation
- Antiviral activity and RNA polymerase degradation following Hsp90 inhibition in a range of negative strand viruses
- Quantitative proteomics reveals that Hsp90 inhibition preferentially targets kinases and the DNA damage response
- Hsp90 modulates actin dynamics: inhibition of Hsp90 leads to decreased cell motility and impairs invasion
- … reticulum vacuolization and valosin-containing protein relocalization result from simultaneous Hsp90 inhibition by geldanamycin and proteasome inhibition by …
- To fold or not to fold: modulation and consequences of Hsp90 inhibition
- Mechanistic studies on Hsp90 inhibition by ansamycin derivatives
- ErbB3 expression predicts tumor cell radiosensitization induced by Hsp90 inhibition
- Inhibition of Hsp90 in Trypanosoma cruzi induces a stress response but no stage differentiation
- Hsp90 Inhibition with Resorcylic Acid Lactones (RALs)
- 3-Arylcoumarin derivatives manifest anti-proliferative activity through Hsp90 inhibition
- Targeting HSF1 sensitizes cancer cells to Hsp90 inhibition
- Combined EGFR/MET or EGFR/Hsp90 inhibition is effective in the treatment of lung cancers codriven by mutant EGFR containing T790M and MET
- Heat shock protein 90 (Hsp90) inhibition targets canonical TGF-β signalling to prevent fibrosis
- Hsp90 inhibition protects against inherited retinal degeneration
- FGFR3 translocations in bladder cancer: differential sensitivity to Hsp90 inhibition based on drug metabolism
- Hsp90 inhibition by 17-DMAG attenuates oxidative stress in experimental atherosclerosis
- Targeting multiple signal transduction pathways through inhibition of Hsp90
- Inhibition of Hsp90 molecular chaperones: moving into the clinic
- Differential effects of Hsp90 inhibition on protein kinases regulating signal transduction pathways required for myoblast differentiation
- Efficacy of Hsp90 inhibition for induction of apoptosis and inhibition of growth in cervical carcinoma cells in vitro and in vivo
- Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition
- Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53/ATM status in chronic …
- Heat-induced Oligomerization of the Molecular Chaperone Hsp90 INHIBITION BY ATP AND GELDANAMYCIN AND ACTIVATION BY TRANSITION METAL …
- Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin
- Phase I–II study of vorinostat plus paclitaxel and bevacizumab in metastatic breast cancer: evidence for vorinostat-induced tubulin acetylation and Hsp90 inhibition in …
- Inhibition of Hsp90: a new strategy for inhibiting protein kinases
- Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells
- Hsp90 inhibition by PU-H71 induces apoptosis through endoplasmic reticulum stress and mitochondrial pathway in cancer cells and overcomes the …
- Sensitivity of epidermal growth factor receptor and ErbB2 exon 20 insertion mutants to Hsp90 inhibition
- Hsp90 inhibition: Elimination of shock and stress
- Inhibition of MDM2 by Hsp90 contributes to mutant p53 stabilization
- Inhibition of N-terminal ATPase on Hsp90 attenuates colitis through enhanced Treg function
- Inhibition of Hsp90 compromises the DNA damage response to radiation
- Hsp90 inhibition enhances cancer immunotherapy by upregulating interferon response genes
- Mineralocorticoid receptor degradation is promoted by Hsp90 inhibition and the ubiquitin-protein ligase CHIP
- Inhibition of ALK, PI3K/MEK, and Hsp90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene
- Protein kinase CK2 protects multiple myeloma cells from ER stress–induced apoptosis and from the cytotoxic effect of Hsp90 inhibition through regulation of the …
- Hsp90 inhibition increases p53 expression and destabilizes MYCN and MYC in neuroblastoma
- Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics
- Hsp90 inhibition enhances PI-3 kinase inhibition and radiosensitivity in glioblastoma
- Receptor ligand-triggered resistance to alectinib and its circumvention by Hsp90 inhibition in EML4-ALK lung cancer cells
- Inhibition of heat shock protein Hsp90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic …
- Hsp90 inhibition by 17-DMAG reduces inflammation in J774 macrophages through suppression of Akt and nuclear factor-κB pathways
- Identification of a new scaffold for Hsp90 C-terminal inhibition
- Hsp90 inhibition protects against biomechanically induced osteoarthritis in rats
- Therapeutic potential of Hsp90 inhibition for neurofibromatosis type 2
- Hsp90 inhibition downregulates thymidylate synthase and sensitizes colorectal cancer cell lines to the effect of 5FU-based chemotherapy
- Hsp90 inhibition overcomes HGF-triggering resistance to EGFR-TKIs in EGFR-mutant lung cancer by decreasing client protein expression and angiogenesis
- Induction of premature senescence by Hsp90 inhibition in small cell lung cancer
- Inhibition of Hsp90 attenuates inflammation in endotoxin-induced uveitis
- Inhibition of Hsp90 down-regulates mutant epidermal growth factor receptor (EGFR) expression and sensitizes EGFR mutant tumors to paclitaxel
- Radiosensitization of human vascular endothelial cells through Hsp90 inhibition with 17-N-allilamino-17-
demethoxygeldanamycin - Efficient synthesis of a novel resorcyclide as anticancer agent based on Hsp90 inhibition
- Inhibition of heat shock protein 90 (Hsp90) as a therapeutic strategy for the treatment of myeloma and other cancers
- UBR1 promotes protein kinase quality control and sensitizes cells to Hsp90 inhibition
- S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities
- Blocking NF-κB and Akt by Hsp90 inhibition sensitizes Smac mimetic compound 3-induced extrinsic apoptosis pathway and results in synergistic cancer cell death
- Hsp90 inhibition as a means of radiosensitizing resistant, aggressive soft tissue sarcomas
- Inhibition of Hsp90 function by ansamycins causes retinoblastoma gene product-dependent G1 arrest
- Hsp90 inhibition and the expression of phenotypic variability in the rainforest species Drosophila birchii
- Combined inhibition of Wee1 and Hsp90 activates intrinsic apoptosis in cancer cells
- Additive viability-loss following hsp70/hsc70 double interference and Hsp90 inhibition in two breast cancer cell lines
- Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone
- Intrinsic inhibition of the Hsp90 ATPase activity
- Resistance to Hsp90 inhibition involving loss of MCL1 addiction
- Hsp90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia
- PI3K-independent mTOR activation promotes lapatinib resistance and IAP expression that can be effectively reversed by mTOR and Hsp90 inhibition
- Enhanced in vivo antitumor efficacy of dual-functional peptide-modified docetaxel nanoparticles through tumor targeting and Hsp90 inhibition
- Molecular mechanism of inhibition of the human protein complex Hsp90–Cdc37, a kinome chaperone–cochaperone, by triterpene celastrol
- Inhibition of Hsp90 function delays and impairs recovery from heat shock
- Hsp90 inhibition induces cytotoxicity via down-regulation of Rad51 expression and DNA repair capacity in non-small cell lung cancer cells
- SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis
- Inhibition of Hsp90 as a special way to inhibit protein kinases
- Disruption of zebrafish somite development by pharmacologic inhibition of Hsp90
- Drug-mediated targeted disruption of multiple protein activities through functional inhibition of the Hsp90 chaperone complex
- 18β-Glycyrrhetinic acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial
- Effect of heat-shock protein-90 (Hsp90) inhibition on human hepatocytes and on liver regeneration in experimental models
- Marked enhancement of lysosomal targeting and efficacy of ErbB2-targeted drug delivery by Hsp90 inhibition
- Hsp90 inhibition by NVP-AUY922 and NVP-BEP800 decreases migration and invasion of irradiated normoxic and hypoxic tumor cell lines
- Inhibition of Hsp90 with AUY922 induces synergy in HER2-amplified trastuzumab-resistant breast and gastric cancer
- 5-Episinuleptolide acetate, a norcembranoidal diterpene from the formosan soft coral Sinularia sp., induces leukemia cell apoptosis through Hsp90 inhibition
- Heat shock protein 90 (Hsp90) is overexpressed in p16-negative oropharyngeal squamous cell carcinoma, and its inhibition in vitro potentiates the effects of …
- Influence of Hsp90 and HDAC inhibition and tubulin acetylation on perinuclear protein aggregation in human retinal pigment epithelial cells
- 17-DMCHAG, a new geldanamycin derivative, inhibits prostate cancer cells through Hsp90 inhibition and survivin downregulation
- Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol
- Destabilization of PDK1 by Hsp90 inactivation suppresses hepatitis C virus replication through inhibition of PRK2-mediated viral RNA polymerase phosphorylation
- Pharmacologic and genetic inhibition of Hsp90-dependent trafficking reduces aggregation and promotes degradation of the expanded glutamine androgen receptor …
- Inhibition of Hsp90 with Pochoximes: SAR and Structure‐Based Insights
- Hsp90 inhibition suppresses lipopolysaccharide-induced lung inflammation in vivo
- Inhibition of GR‐mediated transcription by p23 requires interaction with Hsp90
- Inhibition of heat shock protein 90 (Hsp90) in proliferating endothelial cells uncouples endothelial nitric oxide synthase activity
- Radioresistant human lung adenocarcinoma cells that survived multiple fractions of ionizing radiation are sensitive to Hsp90 inhibition
- Induction of nitric oxide synthase-dependent telomere shortening after functional inhibition of Hsp90 in human tumor cells
- Targeting Hsp90 prevents escape of breast cancer cells from tyrosine kinase inhibition
- Inhibition of Hsp90 function by ansamycins causes downregulation of cdc2 and cdc25c and G2/M arrest in glioblastoma cell lines
- The Hsp70 inhibiting peptide aptamer A17 potentiates radiosensitization of tumor cells by Hsp90 inhibition
- Enhancement of radiation sensitivity in lung cancer cells by celastrol is mediated by inhibition of Hsp90
- Inhibition of Hsp90 by AUY922 preferentially kills mutant KRAS colon cancer cells by activating Bim through ER stress
- Inhibition of Hsp90 leads to cell cycle arrest and apoptosis in human malignant pleural mesothelioma
- Targeted inhibition of Hsp90 by ganetespib is effective across a broad spectrum of breast cancer subtypes
- Molecular imaging of EGFR and CD44v6 for prediction and response monitoring of Hsp90 inhibition in an in vivo squamous cell carcinoma model
- Blocking the survival of the nastiest by Hsp90 inhibition
- Dynamic cycling with Hsp90 stabilizes neuronal nitric oxide synthase through calmodulin-dependent inhibition of ubiquitination
- Hsp90 inhibition induces both protein-specific and global changes in the ubiquitinome
- Inhibition of Hsp90 via 17-DMAG induces apoptosis in a p53-dependent manner to prevent medulloblastoma
- Oxidative inhibition of Hsp90 disrupts the super‐chaperone complex and attenuates pancreatic adenocarcinoma in vitro and in vivo
- Induction of heat shock protein HSPA6 (HSP70B′) upon Hsp90 inhibition in cancer cell lines
- Blocking the heat shock response and depleting HSF-1 levels through heat shock protein 90 (Hsp90) inhibition: a significant advance on current Hsp90 …
- Hsp90 inhibition blocks ERBB3 and RET phosphorylation in myxoid/round cell liposarcoma and causes massive cell death in vitro and in vivo
- Inhibition of the mitochondrial Hsp90 chaperone network: a novel, efficient treatment strategy for cancer?
- Inhibition of Hsp90 could be possible mechanism for anti-cancer property of amniotic membrane
- Dicoumarol down-regulates human PTTG1/Securin mRNA expression through inhibition of Hsp90
- Calpain genetic disruption and Hsp90 inhibition combine to attenuate mammary tumorigenesis
- Hsp90 inhibition enhances antimitotic drug-induced mitotic arrest and cell death in preclinical models of non-small cell lung cancer
- Hsp90 inhibition by AUY922 as an effective treatment strategy against myxoid liposarcoma
- Inhibition of Hsp90 suppresses PI3K/AKT/mTOR signaling and has antitumor activity in Burkitt lymphoma
- Inhibition of Hsp90 acts synergistically with topoisomerase II poisons to increase the apoptotic killing of cells due to an increase in topoisomerase II mediated DNA …
- Combined inhibition of Hsp90 and the proteasome affects NSCLC proteostasis and attenuates cell migration
- The interplay between inhibition of JAK2 and HSP90
- Structural basis for topoisomerase VI inhibition by the anti-Hsp90 drug radicicol
- Inhibition of cell death by a novel 16.2 kD heat shock protein predominantly via Hsp90 mediated lipid rafts stabilization and Akt activation pathway
- Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells
- Targeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease
- Hsp90 inhibition results in apoptosis of Philadelphia acute lymphoblastic leukaemia cells: an attractive prospect of new targeted agents
- Down-regulation of MSH2 expression by Hsp90 inhibition enhances cytotoxicity affected by tamoxifen in human lung cancer cells
- Synthesis of flavokawain analogues and their anti-neoplastic effects on drug-resistant cancer cells through Hsp90 inhibition
- Inhibition of Hsp90 and 70 sensitizes melanoma cells to hyperthermia using ferromagnetic particles with a low Curie temperature
- Inhibition of Hsp90 with resorcylic acid macrolactones: synthesis and binding studies
- Combined BRAF and Hsp90 Inhibition in Patients with Unresectable BRAFV600E-Mutant Melanoma
- Down-regulation of cellular FLICE-inhibitory protein (Long Form) contributes to apoptosis induced by Hsp90 inhibition in human lung cancer cells
- Migration pattern, actin cytoskeleton organization and response to PI3K-, mTOR-, and Hsp90-inhibition of glioblastoma cells with different invasive capacities
- Inhibition of HSP90‐dependent telomerase activity in amyloid β‐induced apoptosis of cerebral endothelial cells
- Hsp90 inhibition in HER2-positive breast cancer cells
- Synthesis of butein analogues and their anti-proliferative activity against gefitinib-resistant non-small cell lung cancer (NSCLC) through Hsp90 inhibition
- Regulating the cytoprotective response in cancer cells using simultaneous inhibition of Hsp90 and Hsp70
- Inhibition of heat shock protein 70 and 90 (Hsp70 and Hsp90) in target spesific cancer treatment
- Dynamic impacts of the inhibition of the molecular chaperone Hsp90 on the T-cell proteome have implications for anti-cancer therapy
- Combined inhibition of extracellular signal-regulated kinases and Hsp90 sensitizes human colon carcinoma cells to ionizing radiation
- Hsp90 inhibition by WK88-1 potently suppresses the growth of gefitinib-resistant H1975 cells harboring the T790M mutation in EGFR
- Identification of mixed lineage leukemia 1 (MLL1) protein as a coactivator of heat shock factor 1 (HSF1) protein in response to heat shock protein 90 (Hsp90) inhibition
- Antiproliferative and proapoptotic activity of GUT-70 mediated through potent inhibition of Hsp90 in mantle cell lymphoma
- Hsp90 inhibition increases SOCS3 transcript and regulates migration and cell death in chronic lymphocytic leukemia
- Hsp90 inhibition suppresses NF-κB transcriptional activation via Sirt-2 in human lung microvascular endothelial cells
- Concomitant inhibition of HSP90, its mitochondrial localized homologue TRAP1 and HSP27 by green tea in pancreatic cancer HPAF‐II cells
- Prospective identification of resistance mechanisms to Hsp90 inhibition in KRAS mutant cancer cells
- Hsp90 inhibition sensitizes head and neck cancer to platin-based chemoradiotherapy by modulation of the DNA damage response resulting in chromosomal …
- Co-inhibition of HSP70/Hsp90 synergistically sensitizes nasopharyngeal carcinoma cells to thermotherapy
- EGFR Exon 20 insertion mutations display sensitivity to Hsp90 inhibition in preclinical models and lung adenocarcinomas
- Boosting the effects of hyperthermia-based anticancer treatments by Hsp90 inhibition
- Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma
- Evaluation of prostate-specific antigen as a novel biomarker of Hsp90 inhibition
- AIDing cancer treatment: reducing AID activity via Hsp90 inhibition
- Pharmacological inhibition of Hsp90 and ras activity as a new strategy in the treatment of HNSCC
- Anti-Candida-biofilm activity of micafungin is attenuated by voriconazole but restored by pharmacological inhibition of Hsp90-related stress responses
- Effects of Hsp90 inhibition in neuroblastoma: analysis of drug sensitivity, target modulation and the influence of bone marrow microenvironment.
- Pharmacological inhibition of Hsp90 activity negatively modulates myogenic differentiation and cell survival in C2C12 cells
- Hsp90 inhibition results in glucocorticoid receptor degradation in association with increased sensitivity to paclitaxel in triple-negative breast cancer
- … β peptide-induced inhibition of endothelial nitric oxide production involves oxidative stress-mediated constitutive eNOS/Hsp90 interaction and disruption of …
- Hsp90 inhibition renders iNOS aggregation and the clearance of iNOS aggregates by proteasomes requires SPSB2
- Hsp90 inhibition without heat shock response
- Hsp90-mediated inhibition of FKBP38 regulates apoptosis in neuroblastoma cells
- Reactive oxygen species-dependent Hsp90 protein cleavage participates in arsenical As+ 3-and MMA+ 3-induced apoptosis through inhibition of telomerase activity …
- Sulphoxythiocarbamates modify cysteine residues in Hsp90 causing degradation of client proteins and inhibition of cancer cell proliferation
- Inhibition of Hsp90 attenuates porcine reproductive and respiratory syndrome virus production in vitro
- Magnetic nanoparticle-mediated hyperthermia therapy induces tumour growth inhibition by apoptosis and Hsp90/AKT modulation
- Changes in heat-shock protein synthesis and thermotolerance of Arabodopsis thaliana seedlings resulting from Hsp90 inhibition by geldanamycin
- Down-regulation of ERK1/2 and AKT-mediated X-ray repair cross-complement group 1 protein (XRCC1) expression by Hsp90 inhibition enhances the gefitinib …
- Combined inhibition of Hsp90 and heme oxygenase-1 induces apoptosis and endoplasmic reticulum stress in melanoma
- Inhibition of Plasmodium falciparum Hsp90 Contributes to the Antimalarial Activities of Aminoalcohol-carbazoles
- Dysregulated fibronectin trafficking by Hsp90 inhibition restricts prostate cancer cell invasion
- Hsp90 inhibition alters the chemotherapy-driven rearrangement of the oncogenic secretome
- Strong antitumor synergy between DNA crosslinking and Hsp90 inhibition causes massive premitotic DNA fragmentation in ovarian cancer cells
- Inhibition and flare patterns of metabolic response to the heat shock protein 90 (Hsp90) inhibitor IPI-504 visualized by FDG-PET in patients (pts) with advanced …
- Inhibition of Hsp90 attenuates pro-inflammatory cytokines and prevents LPS induced liver injury
- Little effect of Hsp90 inhibition on the quantitative wing traits variation in Drosophila melanogaster
- Inhibition of HIV-1 reactivation by a telomerase-derived peptide in a Hsp90-dependent manner
- Tomato plant cell death induced by inhibition of Hsp90 is alleviated by Tomato yellow leaf curl virus infection
- Pharmacologic inhibition of Hsp90 to prevent GLT-1 degradation as an effective therapy for epilepsy
- Effect of inhibition of the ubiquitin-proteasome system and Hsp90 on growth and survival of rhabdomyosarcoma cells in vitro
- Inhibition of Hsp90 augments docetaxel therapy in castrate resistant prostate cancer
- Expression of focal adhesion kinase in uveal melanoma and the effects of Hsp90 inhibition by 17-AAG
- Efficacy of Hsp90 inhibition for the induction of apoptosis and inhibition of growth in cervical carcinoma cells in vitro and in vivo
- In silico investigations on Hsp90 and its inhibition for the therapeutic prevention of breast cancer
- … not HSP90, confers neuroprotection against fatal endotoxemia via augmentation of nitric-oxide synthase I (NOS I)/protein kinase G signaling pathway and inhibition of …
- Hsp90 inhibition suppresses PGE2 production via modulating COX-2 and 15-PGDH expression in HT-29 colorectal cancer cells
- Dual inhibition of Bcr-Abl and Hsp90 by C086 potently inhibits the proliferation of imatinib-resistant CML cells
- Targeting the MYC oncogene in Burkitt lymphoma through Hsp90 inhibition
- Hsp90 inhibition induces destabilization of actin cytoskeleton in tumor cells: functional significance of Hsp90 interaction with F–actin
- Ascorbic acid inhibition of Candida albicans Hsp90-mediated morphogenesis occurs via the transcriptional regulator Upc2
- The targeted inhibition of mitochondrial Hsp90 overcomes the apoptosis resistance conferred by Bcl-2 in Hep3B cells via necroptosis
- Bioactive metabolites from Chaetomium aureum: Structure elucidation and inhibition of the Hsp90 machine chaperoning activity
- Heat shock protein 90 (Hsp90) inhibition in acute myeloid leukemia—Targeting of disease heterogeneity through direct and indirect antileukemic effects
- HER3-Mediated Resistance to Hsp90 Inhibition Detected in Breast Cancer Xenografts by Affibody-Based PET Imaging
- Selective Inhibition of HDAC6 regulates preferential cytotoxicity in cancer cells by modulating p53 and Hsp90 stability
- 2-Aroylquinoline-5, 8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (Hsp90) inhibition
- Epigenetic effects of inhibition of heat shock protein 90 (Hsp90) in human pancreatic and colon cancer
- Quantitative proteomics reveals molecular mechanism of gamabufotalin and its potential inhibition on Hsp90 in lung cancer
- Hsp90 inhibition affects cell metabolism by disrupting mitochondrial protein insertion
- Drug-induced Hsp90 inhibition alleviates pain in monoarthritic rats and alters the expression of new putative pain players at the DRG
- Hsp90 inhibition in adrenocortical carcinoma: Limited drug synergism with mitotane
- Hsp90 inhibition by AT13387 modulates growth factor and cytokine stimulated cell signalling in multiple cell lines.
- Hyponatremia and V2 vasopressin receptor upregulation: a result of Hsp90 inhibition
- Inhibition of hepatitis C virus using siRNA targeted to the virus and Hsp90
- … inhibition of Heat Shock Protein 90 (Hsp90) chaperone function in patienets with metastatic GIST: results of a Phase I Trial of IPI-504, a water-soluble Hsp90 …
- Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome
- Hsp90 inhibition drives degradation of FGFR2 fusion proteins: Implications for treatment of cholangiocarcinoma
- Targeting the Hsp90 C-terminal domain to induce allosteric inhibition and selective client downregulation
- Inhibition of Heat Shock proteins Hsp90 and HSP70 induce oxidative stress, suppressing cotton fiber development
- Hsp90 inhibition targets autophagy and induces a CASP9-dependent resistance mechanism in NSCLC
- MicroPET/CT imaging of AXL downregulation by Hsp90 inhibition in triple-negative breast cancer
- Hsp90 inhibition disrupts JAK-STAT signaling and leads to reductions in splenomegaly in patients with myeloproliferative neoplasms
- Radicicol binding to Swo1/Hsp90 and inhibition of growth of specific temperature-sensitive cell cycle mutants of fission yeast
- Hsp90 inhibition results in a significant delay in tumor progression in a model of emerging EGFR TKI resistance in non-small cell lung cancer
- Inhibition of Hsp90 promotes neural stem cell survival from oxidative stress through attenuating NF-κB/p65 activation
- … docking analysis of the molecular chaperone-kinase interactions: Towards allosteric inhibition of protein kinases by targeting the Hsp90-Cdc37 chaperone machinery
- Phenotypic variability of Arabidopsis thaliana seedlings as a result of inhibition of Hsp90 chaperones
- Antiangiogenic effects associated with the inhibition of Hsp90 in colorectal cancer
- Hsp90 inhibition is a potential therapeutic strategy in treatment of adenocarcinoma of the esophagus
- Hsp90 inhibition as an anticancer strategy: Novel approaches and future directions
- 17-DMAG-loaded nanofibrous scaffold for effective growth inhibition of lung cancer cells through targeting Hsp90 gene expression
- Geldanamycin derivatives as promising anticancer drugs: therapy via Hsp90 inhibition
- Effect of Hsp90 inhibition on Rac activation, cell migration, tumor growth and liver metastasis of human pancreatic carcinoma
- Targeted inhibition of mitochondrial Hsp90 induces mitochondrial elongation in Hep3B hepatocellular carcinoma cells undergoing apoptosis by increasing …
- Traditional and novel mechanisms of heat shock protein 90 (Hsp90) inhibition in cancer chemotherapy including Hsp90 cleavage
- Simultaneous inhibition of Hsp90 and mTOR synergistically reduces tumor growth and angiogenesis of hepatocellular cancer in an experimental model
- … sesterterpenoid-type metabolite, induces apoptosis in prostate LNcap cells via oxidative and ER stress combined with the inhibition of topoisomerase II and Hsp90
- AMH and AMHR2 regulate survival signaling, epithelial-mesenchymal transition (EMT) and resistance to Hsp90 inhibition in non-small cell lung cancer (NSCLC)
- Hsp90 Inhibition Reduces TLR5 Surface Expression and NF-κB Activation in Human Myeloid Leukemia THP-1 Cells
- Overcoming acquired resistance to Hsp90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer
- Evaluating dual Hsp90 and Hsp70 inhibition as a cancer therapy
- Intrinsic proteotoxic stress levels vary and act as a predictive marker for sensitivity of cancer cells to Hsp90 inhibition
- Correction: Strong antitumor synergy between DNA crosslinking and Hsp90 inhibition causes massive premitotic DNA fragmentation in ovarian cancer cells
- Changes in heat shock protein synthesis and thermotolerance of Arabidopsis thaliana seedlings as a result of inhibition of Hsp90 by geldanamycin
- Novel and less explored chemotypes of natural origin for the inhibition of Hsp90
- Hsp90 inhibition attenuates LPS-mediated NF-κB-dependent gene activation by preventing the de-acetylation and maintaining the DNA binding of acetyl-histone H3 …
- Hsp90-mediated inactivation of NF {kappa} B switches autophagy to apoptosis through becn1 transcriptional inhibition in selenite-induced NB4 cells
- … yeast into whether the rapamycin inhibition of heat shock transcription factor (Hsf1) can prevent the Hsf1 activation that results from treatment with an Hsp90 …
- Celastrol Mediated Hsp90 Protein Inhibition in Cancer
- Downregulation of androgen receptors by NaAsO2 via inhibition of AKT‐NF‐κB and Hsp90 in castration resistant prostate cancer
- Transcriptomics-based screening identifies pharmacological inhibition of Hsp90 as a means to defer aging
- Enhanced HIF1α inhibition through dual inhibition of CDK and HSP90
- Hsp90 N-and C-terminal double inhibition synergistically suppresses Bcr-Abl-positive human leukemia cells
- Inhibition of Hsp90 by triptolide (TPL) augments Bortezomib-induced U266 cells apoptosis
- Hsp90 inhibition promotes proteasome function in vascular endothelial cells
- Inhibition of elemene on Hsp90/Raf-1 molecular complex in C6 glioblastoma cells [J]
- Targeted Inhibition Of Mitochondrial Hsp90 Improves Pulmonary Arterial Hypertension
- The targeted inhibition of Hsp90 by a synthetic small molecule, DPide offers an effective treatment strategy against TNBCs
- Epilepsy: Hsp90 inhibition suppresses seizures
- A scaffold merging approach to Hsp90 C-terminal inhibition: synthesis and evaluation of a chimeric library
- Hsp90 Inhibition Reverts IL13-and IL17-Induced Goblet Cell Metaplasia in Human Airway Epithelia
- INVESTIGATION OF THE CELLULAR EFFECTS OF Hsp90 INHIBITION ON HEPATOCELLULAR CARCINOMA CELLS
- RNAi knockdown or chemical inhibition of anaphase-promoting complex components is synthetic lethal with Hsp90 inhibition
- Inhibition Of Hsp90 Repairs The LPS-Induced Ali In Mice
- A comprehensive study to analyze tumor sensitivity to Hsp90 inhibition therapy.
- Trypanosoma cruzi Inhibition of Hsp90 in
- Acquired resistance to Hsp90 inhibition in triple-negative breast cancer
- Inhibition of Hsp90 in Streptomyces coelicolor
- Hsp90 inhibition affects MHC class II presentation of glutamic acid decarboxylase
- Role of PRKD2 in Hsp90 inhibition-mediated suppression of cancer growth
- MRS detection of altered choline metabolism following Hsp90 inhibition
- Hsp90 inhibition radiosensitize head and neck carcinoma via EGFR degradation
- Impact of Hsp90 Inhibition on Viability and Cell Cycle in Relation to p53 Status
- Preclinical efficacy of Hsp90 inhibition by using PF-04942847 in osteosarcoma
- CLU inhibition using OGX-011 is a new adjuvant therapeutic strategy for Hsp90 inhibition in prostate cancer
- Dual inhibition of CDK1 and Hsp90 destabilizes HIF1α and synergistically induces cancer cell death
- Functional inhibition of Hsp90 potentiates the effects of ionizing radiation in colorectal cancer
- Combining Hsp90 Inhibition with Standard Therapies for HER2 Positive Breast Cancer.
- The new molecular target therapy of Hsp90 inhibition in esophageal squamous cell carcinoma
- Hsp90 inhibition decreases ovarian cancer cell proliferation and potentiates platinum sensitivity
- Hsp90 inhibition down regulates EGFR and its effector signaling proteins in pancreatic cancer cell lines
- Synthetic lethal screen identifies candidates that modulate cancer cell sensitivity in response to Hsp90 inhibition.
- CLU inhibition using OGX-011 as an adjuvant therapeutic strategy for Hsp90 inhibition in prostate cancer.
- Inhibition of Hsp90 suppresses BmNPV replication in Bombyx mori
- … : Modulation of the Hsp90 cochaperone carboxy‐terminus HSC70‐interacting protein (CHIP) increases cellular sensitivity to heat shock protein 90 (Hsp90) inhibition
- Heat shock protein 90 (Hsp90) inhibition reduces glomerular filtration rate (GFR) and sodium excretion.
- Changes in choline metabolism as potential biomarkers of Hsp90 inhibition in NEU/HER2-driven mammary carcinoma Oncomouse® cells
- Hsp90 acetylation following histone deacetylase inhibition: A role for the histone acetyltransferases p300 and PCAF
- A67 BREAKDOWN: THE CELLULAR CONTRIBUTION TO PULMONARY HYPERTENSION: Targeted Inhibition Of Mitochondrial Hsp90 Improves Pulmonary Arterial …
- HDAC and Hsp90 inhibition as therapeutic strategy for translocation renal cell carcinoma
- Hsp90 inhibition leads to a differential proteomics profile in non small cell lung cancer cell lines
- THU0057 Inhibition of Heat Shock Protein 90 (Hsp90) Prevents Fibrosis by Targeting Canonical TGF-B Signaling
- Immunostimulatory effects of Hsp90 inhibition: Insights from combinational immunotherapies targeting EphA2
- Proteomic analysis of ubiquitination identifies the interplay between Hsp90 inhibition and CUL5 in the control of autophagy
- TREATMENT OF AVIAN TIBIAL DYSCHONDROPLASIA USING TRADITIONAL CHINESE MEDICINES BY Hsp90 INHIBITION
- Supplementary Materials: Targeting the MYC Oncogene in Burkitt Lymphoma through Hsp90 Inhibition
- Abstract B16: Phenotypic plasticity in the EML cell culture system as a result of Hsp90 inhibition
- Visualizing dual downregulation of IGF-1R and VEGF by Hsp90 inhibition effect in triple negative breast cancer
- Hsp90 Inhibition Leads to the Degradation of O-Linked N-Acetylglucosamine Transferase and to the Reduction of O-GlcNAcylation
- Effect of Hsp90 inhibition in tumor cells Apoptosis and cell migration
- HER2-overexpressing lines are sensitive to Hsp90 inhibition irrespective of p53 status
- Analysis of cell cycle-related gene expressions in MDM2-transfected LNCaP-MST cells after inhibition of HSP90
- Inhibition of Hsp90 overcomes resistance to chemotherapy and radiotherapy in pancreatic cancer
- Cellular and molecular effects of Hsp90 inhibition by 17-AAG in sporadic and hereditary breast cancer
- Hsp90 Inhibition and Cellular Stress Elicits Phenotypic Plasticity in Hematopoietic Differentiation
- Therapeutic inhibition of Hsp90 in a mouse model of diabetic atherosclerosis and nephropathy
- Slow, tight binding inhibition of Hsp90 isoforms correlates with potent anti-proliferative activity in cancer cell lines
- Empirical Modeling the Effect of Hsp90 Inhibition on Cytokines Associated With Impaired Biotransport of Apoptotic Debris
- Effect of Hsp90 inhibition on the gene expression profile of MDM2 transfected LNCaP-MST prostate cancer cells
- Evaluation of biomarkers for imaging and radio-immunotherapy in combination with Hsp90 inhibition in squamous cell carcinomas
- 177Lu-octreotate therapy for neuroendocrine tumours is enhanced by Hsp90 inhibition
- Novobiocin–ferrocene conjugates possessing anticancer and antiplasmodial activity independent of Hsp90 inhibition
- A62 LUNG FIBROSIS: FIBROBLAST BIOLOGY: Hsp90 Inhibition Prevents Lung Fibroblast Activation And Epithelial-Mesenchymal Transition
- Abstract P4-16-05: Hsp90 inhibition potentiates chemotherapy effectiveness in triple negative breast cancer: Role of glucocorticoid receptor signaling
- Discovery of novel NO-releasing celastrol derivatives with Hsp90 inhibition and cytotoxic activities
- Hsp90 inhibition rescues behavioral deficits and reduces tau phosphorylation in ps19 mice model for Alzheimer’s disease (AD)
- Inhibition of heat shock protein 90 (Hsp90) and degradation of client proteins associated with oncogenesis using analogs of Novobiocin
- Hsp90 Inhibition Has Potent Activity Against T-Cell Acute Lymphoblastic Leukemia (T-ALL) Through Degradation Of TYK2 Kinase
- Hsp90 inhibition ameliorates CD4+ T cell‐mediated acute Graft versus Host disease in mice
- Hsp90 inhibition depletes DNA repair proteins to sensitize acute myelogenous leukemia to nucleoside analog chemotherapeutics
- Computational modeling of Hsp90 inhibition illustrates a potential therapy to inhibit immune-mediated inflammation in systemic lupus erythematosus.(87.8)
- Hsp90 inhibition suppresses LPS-mediated NFkB target gene expression without affecting NFkB nuclear translocation in human lung microvascular endothelial cells
- Hsp90 inhibition induced cytotoxicity via downregulation of Rad51 expression and DNA repair capacity in non-small cell lung cancer cells
- Hsp90 inhibition abolishes LPS-mediated NF-κB transcriptional activation independent of IKKβ in human lung microvascular endothelial cells (HLMVEC)(847.7)
- Hsp90 inhibition prevents bacterial lipopolysaccharide-induced and RhoA-mediated signaling leading to paracellular hyper-permeability in human lung microvascular …
- USP22-dependent HSP90AB1 expression promotes resistance to Hsp90 inhibition in mammary and colorectal cancer
- Role for NQO1 and MnSOD in 17AAG-Induced Hsp90 inhibition in Pancreatic Cancer Cells
- Hsp90 inhibition results in GR, AR and JAK protein degradation, decreased triple-negative breast cancer proliferation and increased paclitaxel sensitivity
- Hsp90 inhibition prevents monocrotaline-induced pulmonary hypertension in rats, as revealed by high resolution echocardiography
- Correction: 2-Aroylquinoline-5, 8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (Hsp90) inhibition
- Compromising the constitutive p16INK4a expression sensitizes human neuroblastoma cells to Hsp90 inhibition and promotes premature senescence
- Hsp90 Inhibition Enhances the Anti-Tumor Efficacy of Combination Chemo Immunotherapy Targeting DNA Repair Proteins
- Casting a wide net: Hsp90 inhibition to circumvent resistance to TKIs in EGFR-mutated and ALK-rearranged NSCLC
- Hsp90 inhibition attenuates the LPS-mediated phosphorylation of CREB and STAT3 in human lung microvascular endothelial cells
- Ligand-independent activation of the P2X7 receptor by Hsp90 inhibition stimulates motor neuron apoptosis
- Abstract# 2835: Inhibition of heat shock protein 90 (Hsp90) modulates macrophage stimulating-1 receptor (MSR1) expression and signaling, and reduces pancreatic …
- Pharmacological Inhibition of Hsp90 as a Novel Antitumor Strategy to Target Cytoarchitecture Through Extracellular Matrix Signaling
- Metabolic profiling of drug response in prostate cancer cells following PI3K, MAPK and Hsp90 inhibition using magnetic resonance spectroscopy
- 17-AAG Hsp90 Inhibition as an Effective Therapy for Lymphoma Stem Cells.
- Chemical inhibition of Hsp90 inhibits TNF‐α mediated proliferation and induces apoptosis in human rheumatoid arthritis fibroblast‐like synoviocytes
- Integration of Hsp90 inhibition in combinational immunotherapies targeting receptor tyrosine kinase EphA2
- 17-AAG Mediated Hsp90 Inhibition as an Effective Therapy for Lymphoma Stem Cells
- A Transcriptionally Definable Subgroup of Triple-Negative Breast and Ovarian Cancer Samples Shows Sensitivity to Hsp90 Inhibition
- Visualizing dual downregulation of IGF-1 R and VEGF-A by Hsp90 inhibition effect in triple negative breast cancer
- Abstract A226: ImmunoPET with 89Zr‐DFO‐trastuzumab: Monitoring the pharmacodynamic effects on HER2/neu expression by Hsp90 inhibition in vivo
- Effects of Hsp90 inhibition and/or PKC activation on ErbB2 in MDA-MB-453 cells
- Abstract B103: Hsp90 inhibition targets the dysregulated signal and transcription factor network and malignant phenotype of head and neck squamous cell carcinoma …
- Abstract P1-03-07: Differential Effect of Specific p53 Mutations on Breast Cancer Growth and Response to Hsp90 Inhibition In Vivo
- … # 4975: Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat shock protein 90 (Hsp90) inhibition
- Effect of heat stress and Hsp90 inhibition on T-type calcium currents and voltage-dependent potassium currents in leydig cells
- This is a repository copy of FGFR3 translocations in bladder cancer: differential sensitivity to Hsp90 inhibition based on drug metabolism..
- B28 BARRIER DYNAMICS IN THE PULMONARY CIRCULATION: Hsp90 Inhibition Suppresses Bacterial Endotoxin-Mediated Nf-[kappa] b Transcriptional Activation …
- Abstract B140: Positron emission tomography imaging of HER2 expression and pharmacodynamic response to Hsp90 inhibition with the next-generation ZHER2 …
- Inhibition of heat-shock protein 90 (Hsp90) disrupts mutliple pro-angiogenic signaling pathways in gastric cancers cells in vitro and reduces tumor growth and …
- Hsp90 Inhibition Abrogates the Topoisomerase I Poison-induced G2/M Checkpoint in p53-null Tumor cells by Depleting Chk1 and Wee1
- Heat Shock Protein 90 (Hsp90) Inhibition as a Potential Novel Approach to the Treatment of Patients with ALK Mutated Non-small Cell Lung Cancer (NSCLC)
- MP64-14 TARGETING HEAT SHOCK FACTOR 1 SENSITIZES CASTRATION-RESISTANT PROSTATE CANCER CELLS TO Hsp90 INHIBITION IN PART BY …
- … mutation of PI3K p110alpha subunit in HER2-overexpressing mammary epithelial cells confers a”” stem-like”” phenotype and acute sensitivity to Hsp90 inhibition
- Heat shock protein 90 (Hsp90) inhibition in squamous cell carcinoma of the head and neck (SCCHN): An in vitro analysis with a focus on p16 status.
- Inhibition of Hsp90 by AT13387 Delays the Emergence of
- Acetylation of Hsp90 reverses dexamethasone-mediated inhibition of insulin secretion
- Local Inhibition of Hsp90 to Prevent Intimal Hyperplasia after Balloon Injury
- Combination of Hsp90 and mTOR inhibition promotes pancreatic cancer growth inhibition
- Hsp90 characterization and inhibition: a multi-methodological study
- Immune Expression and Inhibition of Hsp90 in Retinoblastoma
- Immune Expression and Inhibition of Hsp90 in Metastatic Uveal Melanoma
- Therapeutic advantages of inhibition of Hsp90 and proteasomal inhibition in prostate cancer cells
- Immune expression and inhibition of Hsp90 in uveal melanoma
- Synthesis of Novel Hsp90 Inhibotor and Its Inhibition
- Immune Expression and Inhibition of Hsp90 in Human Uveal Melanoma
- Reduction of cardiac TGFβ-mediated profibrotic events by inhibition of Hsp90 with engineered protein
- Inhibition of Hsp90 induces BRCA1 degradation and hypersensitivity to ionizing radiation
- Cancer drug resistance: rationale for drug delivery systems and targeted inhibition of Hsp90 family proteins
- Therapeutic Inhibition Of Hsp90 Attenuates Fibroblast Activation Involved In Severe Fibrotic Lung Disease
- Inhibition of curcumin derivative C1209 on proliferation of CML cells by disrupting Hsp90 chaperon function
- Low-level inhibition of Hsp90 forces cells to tip their (antigenic) hand
- Induction of enhanced tumor-specific immunity by Hsp90 targeted photodynamic therapy (Hsp90-PDT) combined with immune checkpoint inhibition
- Inhibition of Hsp90 overcomes melphalan resistance through downregulation of Src in multiple myeloma cells
- Combinatorial inhibition of mTORC2 and Hsp90 leads to a distinctly effective therapeutic strategy in malignant pheochromocytom.
- Abstract B99: Targeting TPR cochaperones of the Hsp90 molecular chaperone complex for specific inhibition.
- The stress protein response transiently inhibits STAT1 signaling via inhibition of Hsp90 binding
- Inhibition of Hsp90 sensitizes pancreatic cancer in vitro and in vivo to chemo-radiotherapy
- Targeted blockade of Hsp90 impairs DNA-damage response proteins and increases the sensitivity of ovarian carcinoma cells to PARP inhibition
- HSP70/Hsp90 Expression in CA9-22 after thermotherapy and the effect of inhibition of HSP70/Hsp90 expression on the efficacy of thermotherapy
- INHIBITION OF Hsp90 IN TRYPANOSOMA BRUCEI AND PHARMACOKINETIC-
PHARMACODYNAMIC RELATIONSHIPS OF ANTITRYPANOSOMALS - Inhibition of Hsp90 chaperone and 26S proteasomal activities by efrapeptins in breast cancer cells
- Functional inhibition of Hsp90 induces G0/G1 arrest and downregulates thymidylate synthase in colorectal cancer
- Inhibition of heat shock protein 90 (Hsp90) by diterpenoids from roots of Zhumeria majdae
- C76 HEAT SHOCK PROTEIN: Therapeutic Inhibition Of Hsp90 Attenuates Fibroblast Activation Involved In Severe Fibrotic Lung Disease
- Inhibition of novobiocin on proliferation of HL-60/Bcr-Abl cells involves disruption of Hsp90 chaperon function
- 292 INHIBITION OF Hsp90 AGGRAVATES THE EFFECTS OF HEAT SHOCK ON DEVELOPMENTAL COMPETENCE OF BOVINE OOCYTES
- V599E B-Raf as the next Hsp90 client protein: A novel strategy for selective inhibition of mutated B-Raf
- Inhibition of Hsp90 enhances T cell-mediated antitumor immune responses through expression of interferon-alpha response Genes
- Hsp90 protects LPS induced pancreatic inflammation of AR42J cells by inhibition of p38MAPK/NF-κB pathways
- Inhibition of Hsp90 with NVP-AUY922 induces a synergistic effect in HER2-amplified, trastuzumab-resistant breast and gastric cancer
- Inhibition of histone deacetylases 1 and 2 increases p21CIP1/WAF1 expression independent of p53 and Hsp90 in colon cancer cells
- Inhibition of Hsp90 and its Client Kinase FAK has Therapeutic Potential in Squamous Cell Carcinomas of the Uterine Cervix and Oral Cavity
- In vitro and in vivo inhibition of the Hsp90 molecular chaperone by novel, synthetic, potent pyrazole/isoxazole resorcinol 5-amide analogs
- Combined Pharmacological Inhibition of Cyclophilins, FK506-Binding Proteins, Hsp90, and Hsp70 Protects Cells From Clostridium botulinum C2 Toxin
- Inhibition of Hepatitis C Replication by Targeting the Molecular Chaperone Hsp90: Synthesis and Biological Evaluation of 4,5,6,7‐Tetrahydrobenzo[1,2‐d]
thiazole … - Benzo [a] pyrene Inhibition of Follicular Development and Survival Is Associated with Dysregulation of Hsp90, Bax, CYP1A1, and CYP1B1 Expression.
- Inhibition of heat stress-related apoptosis of chicken myocardial cells through inducing Hsp90 expression by aspirin administration in vivo
- Abstract NT-094: TARGETED INHIBITION OF Hsp90 IMPAIRS DNA-DAMAGE RESPONSE PROTEINS AND INCREASES THE SENSITIVITY OF OVARIAN …
- Targeted inhibition of histone deacetylase leads to suppression of Ewing sarcoma tumor growth through an unappreciated EWS-FLI1/HDAC3/Hsp90 signaling axis
- Inhibition of heat shock protein 90 (Hsp90) sensitizes HER2-negative breast cancer derived MDA-MD-231 cell line to the cytotoxic effect of troglitazone (TRO)
- Effects of Hsp90 inhibition on galectin3 expression in human monocytic cell line THP1
- Radiosensitization of human tumor cells by Hsp90 inhibition
- Hsp90 inhibition as a way to treat cancer
- Hsp90 inhibition causes heterochronies in the skull ossification sequences of Pleurodeles waltl (Urodela). Evolutionary implications.
- Hsp90 Inhibition verbessert die antitumor Effektivität von Rapamycin durch Blockade von Akt und NF-κB
- Inhibition von Hsp90 in Gemcitabine-und 5-Fluorouracil-resistenten Pankreaskarzinomen
- Inhibition of Hsp90 with pochoximes: structure-activity relationship and structure-based insights
- Inhibition von Heat-shock Protein 90 ( Hsp90 ) mittels EC154, einem neuen synthetischen Hsp90 Antagonist, reduziert das Wachstum von humanen Magen-und…
- VII. Molekulare Onkologie: Therapie Inhibition von Heat-shock Protein 90 ( Hsp90 ) mittels EC154, einem neuen synthetischen Hsp90 Antagonist, reduziert das…