“Ashwagandha”–This Ancient Indiant Plant Completely Rebuilds Your Brain & extend Lifespan 10-Hydroxy-2-Decenoic Acid, The Major Lipid Component Of Royal Jelly, extends The Lifespan Of Caenorhabditis Elegans Through Dietary Restriction And Target Of … 2-Secd Treatment extends Lifespan, Improves Healthspan And Enhances Resistance To Stress In Caenorhabditis Elegans 35. Systemic Administration Of Raav6-Microdystrophin Preserves Muscle Function And extends Lifespan In The Dystrophin-/Utrophin-Mouse Model Of Severe … 4E-Bp extends Lifespan Upon Dietary Restriction By Enhancing Mitochondrial Activity In Drosophila 629. Intravenous Delivery Of A Mtmr2-Encoding Aav9 Vector extends Lifespan And Improves Muscle Function In Mice With X-Linked Myotubular Myopathy 713. Intracsf Administration Of Aav9/Mecp2 extends Lifespan Of Mecp2-Null Mice While Preventing Toxicity Associated With Iv Administration A Better Strategy To extend The Proliferative Lifespan Of Human T-Cells In Vitro. A Carboxyfullerene Sod Mimetic Improves Cognition And extends The Lifespan Of Mice A C-Terminal Truncated Mutation Of Spr-3 Gene extends Lifespan In Caenorhabditis Elegans A Cytosolic Catalase Is Needed To extend Adult Lifespan In C. Elegans Daf-C And Clk-1 Mutants A Deuterohemin Peptide extends Lifespan And increases Stress Resistance In Caenorhabditis Elegans A Double Whammy For Aging? Rapamycin extends Lifespan And Inhibits Cancer In Inbred Female Mice A Fucose Containing Polymer-Rich Fraction From The Brown Alga Ascophyllum Nodosum Mediates Lifespan increase And Thermal-Tolerance In Caenorhabditis Elegans, By … A High-Fat Jelly Diet Restores Bioenergetic Balance And extends Lifespan In The Presence Of Motor Dysfunction And Lumbar Spinal Cord Motor Neuron Loss In Tdp … A Matter Of Life And Death: Discovering The Factors That Control The Lifespan Of The Cells That Form Blood Clots Could Improve Cancer Treatments And extend The Shelf-Life Of … A New Active Power‐Decoupling Topology And Control Mechanism To extend The Lifespan And Reduce The Number Of Passive Components A New Schizosaccharomyces Pombe Chronological Lifespan Assay Reveals That Caloric Restriction Promotes Efficient Cell Cycle Exit And extends Longevity A Novel Disease Caused By increase Of The Lifespan: Chronic Cutaneous Insufficiency Syndrome Or Dermatoporosis A Novel Endogenous Indole Protects Rodent Mitochondria And extends Rotifer Lifespan A Novel Gene, Ecl1+, extends The Chronological Lifespan In Fission Yeast A Novel Response To Cellular Hypoxia increases Lifespan In C. Elegans A Nutritional Supplement Containing Lactoferrin Stimulates The Immune System, extends Lifespan, And Reduces Amyloid Β Peptide Toxicity In Caenorhabditis Elegans A Parasite That increases Host Lifespan A Persistent Level Of Cisd2 extends Healthy Lifespan And Delays Aging In Mice A Reduction In Age-Enhanced Gluconeogenesis extends Lifespan A Regulated Response To Impaired Respiration Slows Behavioral Rates And increases Lifespan In Caenorhabditis Elegans A Salicylic Acid Derivative extends The Lifespan Of Caenorhabditis Elegans By Activating Autophagy And The Mitochondrial Unfolded Protein Response A Single Intrauterine Infusion Of Sustained Recombinant Ovine Interferon-Τ extends Corpus Luteum Lifespan In Cyclic Ewes A Small Molecule Modulator Of Prion Protein increases Human Mesenchymal Stem Cell Lifespan, Ex Vivo Expansion, And Engraftment To Bone Marrow In Nod/Scid Mice A Steroid Hormone That extends The Lifespan Of Caenorhabditis Elegans A Steroidal Saponin From Ophiopogon Japonicus extends The Lifespan Of Yeast Via The

A Central Role For Stat3 In Il‐6‐Induced Regulation Of Growth And Differentiation In M1 Leukemia Cells. A High-Affinity Protein Binder That Blocks The Il-6/Stat3 Signaling Pathway Effectively Suppresses Non–Small Cell Lung Cancer A Muscle Specific Protein “Myoferlin” Modulates Il-6/Stat3 Signaling By Chaperoning Activated Stat3 To Nucleus A Muscle-Specific Protein 'Myoferlin'Modulates Il-6/Stat3 Signaling By Chaperoning Activated Stat3 To Nucleus A New Bioassay For Measuring The Strength Of Il-6/Stat3 Signal Inhibition By Tocilizumab In Patients With Rheumatoid Arthritis A Novel Anti-Cancer Agent Icaritin Suppresses Hepatocellular Carcinoma Initiation And Malignant Growth Through The Il-6/Jak2/Stat3 Pathway A Novel Positive Feedback Regulation Between Long Noncoding Rna Uicc And Il-6/Stat3 Signaling Promotes Cervical Cancer Progression A Novel Role For Histone Deacetylase 6 In The Regulation Of The Tolerogenic Stat3/Il-10 Pathway In Apcs A Novel Small Molecule, Lll12, Inhibits Il-6 Induced Stat3 Phosphorylation And Nuclear Translocation A Shift In The Il-6/Stat3 Signalling Pathway Imbalance Towards The Shp2 Pathway In Severe Asthma Results In Reduced Proliferation Process A Small Molecule, Lll12 Inhibits Constitutive Stat3 And Il‐6‐Induced Stat3 Signaling And Exhibits Potent Growth Suppressive Activity In Human Multiple Myeloma … A Socs-1 Peptide Mimetic Inhibits Both Constitutive And Il-6 Induced Activation Of Stat3 In Prostate Cancer Cells A Stat3/Nfκb Complex Is Necessary For The Expression Of Fascin In Metastatic Breast Cancer Cells In Response To Il-6 And Tnf-Α A Synthesis Of Novel Pyrazolylthienopyrimidine Derivatives As Il-6/Stat3 Inhibitors A1. 15 Il-6 Driven Stat3 Phosphorylation In Circulating Lymphocytes Is Specific For Cd4+ T Cells In Early Rheumatoid Arthritis A20 Promotes Liver Regeneration By Decreasing Socs3 Expression To Enhance Il‐6/Stat3 Proliferative Signals A63 Death To The Infidels! Cellular Apoptosis In Lung Disease: Notch Regulation Of Cell Density-Dependent Apoptosis Via Il-6/Stat3 Signaling Pathway Ab0040 Il-29 Induces Production Of Il-6 And Il-8 In Rheumatoid Arthritis Synovial Fibroblasts Via Jak/Stat3 And Mapk/Nf-Kb Signaling Pathways Ab0100 Mtx Combined With Ctx Inhibited Il-6 Induced Jak2-Stat3 Activation And The Induction Of P-Gp In Peripheral Blood Lymphocytes Of Rheumatoid Arthritis Patients Ab0214 Tlr2 Ligation Induces The Production Of Il-23/Il-17 Via Il-6, Stat3 And Nf-Kb Pathway In Patients With Primary Sjögren'S Syndrome Aberrant Expression Of Cul4A Is Associated With Il-6/Stat3 Activation In Colorectal Cancer Progression Aberrantly Expressed Fra-1 By Il-6/Stat3 Transactivation Promotes Colorectal Cancer Aggressiveness Through Epithelial–Mesenchymal Transition Abnormally Expressed Junb Transactivated By Il-6/Stat3 Signaling Promotes Uveal Melanoma Aggressiveness Via Epithelial–Mesenchymal Transition Abstract B36: Inhibition Of The Autocrine Il-6-Jak2-Stat3-Calprotectin Axis As Targeted Therapy For Hr-/Her2+ Breast Cancers Abstract B68: Targeted Inhibition Of Tgfβr2 Reduces Il-6 Production From Cancer-Associated Fibroblasts, Suppresses Stat3 Activation In Pancreatic Cancer Cells And … Abstract P2-06-07: Prkcq Regulates Taxol Sensitivity Of Triple Negative Breast Cancer Cells Via Il-6/Stat3 Signaling Abstract# 1154: Il-6 Induces Il-10 Expression And Promotes Cancer Progression After Activation Of Stat3 In Human Colon Carcinoma Cells Abstract# 1546: The Il-6/Jak2/Stat3 Signaling Pathway Upregulates Er-\# 946; Expression In Lung Adenocarcinoma Cells Abstract# 4893: Quantitative Phosphoproteomic Analysis Of Stat3/Il-6/Hif1\# 945; Signaling Partners In Ns11 Glioblastoma Stem Cells With Multiplexed Tandem Mass … Abstract# 5489: Sorafenib Inhibits Il-6 Induced Stat3 Signaling In Cholangiocarcinoma Cells And Demonstrates In

A Hopeful Natural Product, Pristimerin, Induces Apoptosis, Cell Cycle Arrest, And Autophagy In Esophageal Cancer Cells Aberrantly Expressed Fra-1 By Il-6/Stat3 Transactivation Promotes Colorectal Cancer Aggressiveness Through Epithelial–Mesenchymal Transition Acquisition Of Resistance To Trastuzumab In Gastric Cancer Cells Is Associated With Activation Of Il-6/Stat3/Jagged-1/Notch Positive Feedback Loop Activation Of Stat3 In Human Gastric Cancer Cells Via Interleukin (Il)-6-Type Cytokine Signaling Correlates With Clinical Implications Anticancer Activity Of Pristimerin In Epidermal Growth Factor Receptor 2-Positive Skbr3 Human Breast Cancer Cells Anticancer Activity Of Pristimerin In Ovarian Carcinoma Cells Is Mediated Through The Inhibition Of Prosurvival Akt/Nf-Κb/Mtor Signaling Anticancer Potential And Molecular Targets Of Pristimerin: A Mini-Review Anticytomegalovirus Activity Of Pristimerin, A Triterpenoid Quinone Methide Isolated From Maytenus Heterophylla (Eckl. & Zeyh.) Antifungal Activity Of Maytenin And Pristimerin Antifungal Properties Of Pristimerin And Celastrol Isolated From Celastrus Hypoleucus Anti-Inflammatory Effect Of Pristimerin On Lipopolysaccharide-Induced Inflammatory Responses In Murine Macrophages Antiproliferative Activity Of Pristimerin Isolated From Maytenus Ilicifolia (Celastraceae) In Human Hl-60 Cells Antitumoral, Mutagenic And (Anti) Estrogenic Activities Of Tingenone And Pristimerin Aspirin Induces Apoptosis Through The Blockade Of Il-6-Stat3 Signaling Pathway In Human Glioblastoma A172 Cells Aspirin Promotes Apoptosis In A Murine Model Of Colorectal Cancer By Mechanisms Involving Downregulation Of Il-6–Stat3 Signaling Pathway Autocrine Il-6-Induced Stat3 Activation Contributes To The Pathogenesis Of Lung Adenocarcinoma And Malignant Pleural Effusion Combination Of Pristimerin And Paclitaxel Additively Induces Autophagy In Human Breast Cancer Cells Via Erk1/2 Regulation Deletion Of The Innate Immune Nlrp3 Receptor Abolishes Cardiac Ischemic Preconditioning And Is Associated With Decreased Il-6/Stat3 Signaling Dna Damage Induces The Il-6/Stat3 Signaling Pathway, Which Has Anti-Senescence And Growth-Promoting Functions In Human Tumors Dysregulated Mir-124 And Mir-200 Expression Contribute To Cholangiocyte Proliferation In The Cholestatic Liver By Targeting Il-6/Stat3 Signalling Embelin Reduces Colitis-Associated Tumorigenesis Through Limiting Il-6/Stat3 Signaling Epigenetic Alterations In Cholangiocarcinoma-Sustained Il-6/Stat3 Signaling In Cholangio-Carcinoma Due To Socs3 Epigenetic Silencing Hepatic Acute Phase Proteins–Regulation By Il-6-And Il-1-Type Cytokines Involving Stat3 And Its Crosstalk With Nf-Κb-Dependent Signaling Hmgb1-Il-23-Il-17-Il-6-Stat3 Axis Promotes Tumor Growth In Murine Models Of Melanoma Hplc Profile And Simultaneous Quantitative Analysis Of Tingenone And Pristimerin In Four Celastraceae Species Using Hplc-Uv-Dad-Ms Il-17 Induces Akt-Dependent Il-6/Jak2/Stat3 Activation And Tumor Progression In Hepatocellular Carcinoma Il-6 Promotes Head And Neck Tumor Metastasis By Inducing Epithelial–Mesenchymal Transition Via The Jak-Stat3-Snail Signaling Pathway Il-6 Trans-Signaling Modulates Tlr4-Dependent Inflammatory Responses Via Stat3 Il-6 Trans-Signaling Via Stat3 Directs T Cell Infiltration In Acute Inflammation Il-6/Stat3/Tff3 Signaling Regulates Human Biliary Epithelial Cell Migration And Wound Healing In Vitro Il-6–Gp130–Stat3 In T Cells Directs The Development Of Il-17+ Th With A Minimum Effect On That Of Treg In The Steady State Improved Extraction Of The Natural Anticancerigen Pristimerin From Mortonia Greggii Root Bark Using Green Solvents And Aqueous Two-Phase Systems Inducible Microrna-223 Down-Regulation Promotes Tlr-Triggered Il-6 And Il-1Β Production In Macrophages By Targeting Stat3 Induction Of Cell‐Cycle Arrest And Apoptosis In Human Cholangiocarcinoma Cells By Pristimerin Inhibition Of Htert In Pancreatic Cancer Cells By Pristimerin Involves Suppression Of Epigenetic Regulators Of Gene Transcription Inhibition Of Il-6/Stat3 Axis And Targeting Axl And Tyro3

A Distinct Pattern of Beclin-1 Staining Helps Distinguish Sessile Serrated Adenomas A non-canonical MEK/ERK signaling pathway regulates autophagy via regulating Beclin 1 A novel role of Beclin-1, cytokinetic abscission A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation A role for autophagic protein Beclin 1 early in lymphocyte development A tumor-associated mutation of FYVE-CENT prevents its interaction with Beclin 1 and interferes with cytokinesis A179L, a new viral Bcl2 homolog targeting Beclin 1 autophagy related protein A6799 Ginsenoside Rb1 alleviate ox-LDL induced HUVEC senescence via SIRT1/Beclin-1/autophagy axis A80-C MOLECULAR AND IMMUNOBIOLOGY OF LUNG CANCER: High Levels Of Beclin-1 In Induced Sputum Of Lung Cancer Patients As A Marker Of Increased … Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency Aberrant Beclin 1 expression is closely linked to carcinogenesis, differentiation, progression, and prognosis of ovarian epithelial carcinoma Aberrant expression of Beclin-1 and LC3 correlates with poor prognosis of human hypopharyngeal squamous cell carcinoma Abstract C150: CaMKKβ-mediated phosphorylation of Beclin 1 regulates autophagy and cell differentiation in neuroblastoma cells. Abstract P046: Hsp20 Promotes Cardiac autophagy via Interaction with Beclin-1 Abstract# 1872: Mechanistic role of acetylated heat shock protein 70 in the VPS34/Beclin-1 triggered autophagy in breast cancer cells Abstract# 387: Regulation of autophagy by the Beclin 1-targeted microRNA in cancer cells Abstract# 867: Beclin 1 augments the action of a polyamine analogue in MCF-7 breast cancer cells Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth Activating transcription factor 3 protects against pressure-overload heart failure via the autophagy molecule Beclin-1 pathway Activation of RIG-I-mediated antiviral signaling triggers autophagy through the MAVS-TRAF6-Beclin-1 signaling axis Acute phase expression pattern of ZnTs, LC3, and Beclin-1 in rat Hippocampus and its regulation by 3-methyladenine following recurrent neonatal seizures Adiponectin inhibits inflammatory cytokines production by Beclin‐1 phosphorylation and B‐cell lymphoma 2 mRNA destabilization: role for autophagy induction Age-dependent molecular alterations in the autophagy pathway in HIVE patients and in a gp120 tg mouse model: reversal with Beclin-1 gene transfer Akt-Mediated Regulation of autophagy and Tumorigenesis Through Beclin 1 Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation Aldosterone Induces autophagy via an ERK-JNK/Phospho-Bcl-2/Beclin-1 Dependent Pathway in Isolated Adult Rat Ventricular Myocytes Alleviation of autophagy by knockdown of Beclin-1 enhances susceptibility of hippocampal neurons to proapoptotic signals induced by amino acid starvation All-Trans-Retinoid Acid (ATRA) Induced Upregulation of autophagy Related Proteins (LC3–1, II and Beclin 1) in Acute Promyelocytic Leukemia Allyl Isothiocyanate Induces autophagy through the Up-Regulation of Beclin-1 in Human Prostate Cancer Cells Alterations of apoptosis and autophagy in developing brain of rats with epilepsy: changes in LC3, P62, Beclin-1 and Bcl-2 levels Altered mTOR and Beclin-1 mediated autophagic activation during right ventricular remodeling in monocrotaline-induced pulmonary hypertension Alternative messenger RNA splicing of autophagic gene Beclin 1 in human B-cell acute lymphoblastic

  Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL Senescent cells, formed in response to physiological and oncogenic stresses, facilitate protection from tumourigenesis and aid in tissue repair. However, accumulation of such cells in tissues contributes to age-related pathologies. Resistance of senescent cells to apoptotic stimuli may contribute to their accumulation, yet the molecular mechanisms allowing their prolonged viability are poorly characterized. Here we show that senescent cells upregulate the anti-apoptotic proteins BCL-W and BCL-XL. Joint inhibition of BCL-W and BCL-XL by siRNAs or the small-molecule ABT-737 specifically induces apoptosis in senescent cells. Notably, treatment of mice with ABT-737 efficiently eliminates senescent cells induced by DNA damage in the lungs as well as senescent cells formed in the epidermis by activation of p53 through transgenic p14ARF. Elimination of senescent cells from the epidermis leads to an increase in hair-follicle stem cell proliferation. The finding that senescent cells can be eliminated pharmacologically paves the way to new strategies for the treatment of age-related pathologies. 1088: Novel Bispecific Antisense Oligonucleotides Inhibiting Both Bcl-2 And Bcl-Xl Expression Induce Apoptosis And Enhance Chemosensitivity In Human … 130 Regulates Cardiac Myocyte Survival In Doxorubicin-Induced Apoptosis Through Phosphatidylinositol 3-Kinase/Akt Phosphorylation And Bcl-Xl/Caspase-3 Interaction 148 Epidermal Growth Factor Induces Bcl-Xl Gene Expression And Reduces Apoptosis In Porcine Parthenotes Developing In Vitro 168 Molecular Interaction Between Bcl-Xl And Bnip3 Determines The Cell Fate Of Hypertrophic Chondrocytes 1-Bp Inhibits Nf-Κb Activity And Bcl-Xl Expression In Astrocytes In Vitro And Reduces Bcl-Xl Expression In The Brains Of Rats In Vivo 201. A Bcl-Xl Antisense Antisense Antisense Adenoviral V Adenoviral V Adenoviral Vector: A Novel And Novel And Effective Pro-Apoptotic Gene Therapy Construct 21P Role Of Cytoplasmic Bcl-Xl In Interplay Apoptosis And Autophagy In Combination Of Genistein With Radiation-Induced Cell Death 2249081. Bcl-Xl Transformed Peanut (Arachis Hypogaea L.) Exhibits Paraquat Tolerance 2-Methoxy Antimycin Reveals A Unique Mechanism For Bcl-Xl Inhibition 3′-Deoxy-3′-18F-Fluorothymidine Pet/Ct To Guide Therapy With Epidermal Growth Factor Receptor Antagonists And Bcl-Xl Inhibitors In Non–Small Cell Lung Cancer 326-Lb: Bcl-Xl/Bcl2L1 Is A Critical Anti-Apoptotic Protein That Suppresses Bak To Promote Pancreatic Specification From Human Pluripotent Stem Cells 3D-Qsar Pharmacophore Modeling And In Silico Screening Of New Bcl-Xl Inhibitors 3-Thiomorpholin-8-Oxo-8H-Acenaphtho [1, 2-B] Pyrrole-9-Carbonitrile (S1) Derivatives As Pan-Bcl-2-Inhibitors Of Bcl-2, Bcl-Xl And Mcl-1 4 Monoclonal Antibody, Induces Death Receptor 4-Mediated Apoptotic Cell Death In Anaplastic Thyroid Cancer Cells Via Downregulation Of Bcl-Xl With Reactive Oxygen … 4-1Bb Promotes The Survival Of Cd8+ T Lymphocytes By Increasing Expression Of Bcl-Xl And Bfl-1 5‐Azacytidine Specifically Inhibits The Nih‐3T3 Pcd Process Induced By Tnf‐Alpha And Cycloheximide Via Affecting Bcl‐Xl 834. Protective Effect Of Bcl-Xl Gene Expression On The Radiation-Induced Acute Intestinal Injuries 86 Mesenchymal Stem Cells Induce Lymphocytes Apoptosis Independent Of Bim And Bcl-Xl In Lupus Mice 926. Bcl-Xl Gene Transfer Improves Graft Survival And Prolongs The Cold-Preservation Time In The Heart Transplantation 947. Rnai-Mediated Bcl-Xl Depletion Sensitizes Pancreatic Cancer Cells To Tnf [Alpha] Induced Apoptosis 947. Rnai-Mediated Bcl-Xl Depletion Sensitizes Pancreatic Cancer Cells To Tnfα Induced Apoptosis 97P At-101 (-/-Gossypol) In