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May 20, 2020

AUTONOMOUS / NOOTROPIC TOUR DE FORCE 💥🧠💥 200:1

September 18, 2020

VICTORIOUS : Science Based Anti Viral Formula 200:1

Name: VICTORIOUS : Science Based Anti Viral Formula 200:1
SKU: 17048
Price: 275.00 USD
Availability: InStock
Rating: 5.00 (26 reviews)

Rated 5.00 out of 5 based on 26 customer ratings

(26 customer reviews)

$275.00

SKU: N/A Categories: Exclusive Products, Featured

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introducing

INTERSTELLAR blend

“victorious”

SCIENCE BASED INGREDIENTS

THE MOST COMPREHENSIVE ALL NATURAL ANTIVIRAL FORMULA EVER CREATED

Featuring: 1-Dehydrogingerdione – Zingiber Officinale (Ginger)• 3,2᾿Dihydroxyflavone (3,2᾿Dhf) & 3,4᾿Dihydroxyflavone (3,4᾿Dhf) – Trifolium Repens L. • 6-Gingerol – Zingiber Officinale (Ginger)• Acidicheteroglucan – Tremella Fuciformis • Aconitum Carmichaelii Debx • Ailanthus Altissima Stem Bark • Allantoin – Glyoxylic Acid • Alphitonia Philippinensis Stems • Amygdalin – Semen Armeniacae Amarum • Anemarrhena Asphodeloides • Angelica Sinensis (Oliv.) Diels • Apigenin – Celery • Arctigerin, Arctin – Burdock (Arctium Lappa) • Artemisinin – Artemisia Annua • Aspalathin – Rooibos Tea • Atractylodin ,Β-Eudesmol, Hinesol, Hydroxy-Atractylo – Rhizoma Areactylodis Lanceae • Baicalein – Scutellaria Baicalensis Georgi • Benzaldehyde – Laurus Nobilis Leaves • Berberine – Coptis Chinensis • Beta-Sitosterol – Rice Bran Oil • Betulinic Acid – Betula Platyphylla Suk Bark • Bisdemethoxycurcumin – Turmeric Rhizome • Brachyamide B – Piper Boehmeriaefolium (Miq.) C. Dc • Bulbocapnine – Corydalis Decumbens(Thunb.) • Caffeic Acid – Cimicifuga Simplex (Dc.) Wormsk. Ex Turcz.Root • Calanolide A – Calophyllum Lanigerum • Campesterol – Rapeseed Oil • Carvacrol – Oregano • Chavicine – Black Pepper • Chelidimerine – Chelidonium Majus • Chlorogenic Acid – Green Coffee Bean • Chrysin – Pinus Mon-Ticola Dougl • Cinanserin – Cinnamic Acid • Cinnamomum Cassia Presl Dried Bark • Cirsilineol – Cirsium Lineare (Thunb.) Sch. • Cirsimaritin – Rabdosia Eriocalyx • Cis-Capsaicin (Civamide) – • Colchicine – Colchicum Autumnale L. • Cordifolioside A – Viola Verecunda • Crategolic Acid – Hawthorn • Curcumin – Turmeric Root • Cycloastragenol – Astragalus Membranaceus • Cyclocurcumin – Turmeric Root • Demethoxycurcumin – Turmeric Root • Dianthus Caryophyllus Seed – Carnation • Dioscin, Diosgenin – Wild Yam （Dioscorea Oppositae Thunb）• Douchi (Semen Sojae Praepatum) – Semen Sojae Praepatum • Egcg – Green Tea • Emodin – Rhubarb • Eriodictyol – Lemon • Eugenitin – Clove • Ferruginol – Podocarpus Ferruginea • Fisetin – Rhus Succedanea L • Flavonol Glucoside – Trichilia Connaroides Leaves • Forskolin – Coleus Forskohlii • Fructus Perillae – Perillafrutescens • Fumarophycine – Laptopyrum Reichb • Galangin – Alpinia Officinarum Hance Root • Gallic Acid – Rheumpalmatum L.Root • Genistein – Genista Tinctoria Linn Root • Glycyrrhizic Acid – Licorice Root • Gossypol – Cotton Seed • Guineensine – Piper Longum L. • Gypsum Fibrosum – Gypsum • Hawthorn Flavone – Crataegus Pinnatifida Bunge • Herba Dendrobii – Dendrobium Nobile Lindl • Herbacetin – Flaxseed • Hesperetin – Citrus Aurantium • –Hesperidin Nobiletin B-Phellandrene – Pericarpium Citri Reticulatae • Himachalol – Cupressus Funebris Endl. • Honokiol – Magnolia Officinalis • Houttuynia Cordata – Houttuynia Cordata Thunb • Hypericin Pseudohypericin Protohypericin – Forsythia Suspensa • Isochavicine – Pepper • Isoliquiritigenin – Glycyrrhiza Uralensisfisch Root • Isopiperine – Pepper • Isothymonin – Kaempferia Galanga L • Jatrorrhizine – Phellodendron Amurense Rupr. • Jujuboside A+B – Jujube • Kaempferol – Kaempferol Galanga L • Kaempferol 3-O-Robinobioside – Robinia Pseudoacacia L. • Leachianone – Morus Alba Root Bark • Lepidium Meyenii (Maca ) • Lily – Lilium Auratum • Luteoforol (A Flavan-4-Ol) – Peanut Shell • Luteolin – Peanut Shell • Lycoris Radiata – Lycoris Radiata (L’her.) Herb. • Macaranga Barteri Leaves • Maclura Cochinchinensis (Loureiro) Corner Root • Magnoflorine – Thalictrum Aquilegifolium Root • Marrubium Peregrinum L (Lamiaceae) • Meliacine – Melia Azedarach L • Mint – Mentha Haplocalyx Briq.• Morroniside,7-0-Methylmorroniside, Sweroside, Loganin, Cornus-Tannin 1,2,3 – Cornus Officinalis (Fructus Corni) • Morroniside,Cornus-Tannin 1,2,3 – Fructus Corni • Myricetin – Black Bayberry Fruit • N-Acetylcysteine ethyl ester (NACET) • Naringenin – Amacardi-Um Occidentale L.) • Ndoxyl-Β-Glucoside Uridine, Salicylic Acid,Daucosterol, Β-Sitostero – Radix Isatidis P.E (Satis Tinctoria L. Isatis Indigotica Fort.) • Nothofagin – Aspalathus Linearis • Oleanolic Acid – Olea Europaea L.Leaves • Olomoucine Ii – • Ophiocarpine – Corydalis Ophiocarpa Hook. F. Et Thoms • Ophiopogonin A B C D – Ophiopogon Root • Orientin – Globeflower • Oxypeucedanin Stiamasterol Β-Sitosterol Β-Daucosterin – Angelica Dahurica • Paeoniflorin – Radix Paeoniae Rubra • Patrinia Villosa Juss. – Patrinia Villosa (Thunb. ) Juss. • Peach Kernel – Emen Persicae • Pectolinarin – Linaria Vulgaris Hill Subsp. • Pelargonium Sidoides – Pelargonium Peltatum (L.) Ait. • Pentadienoylpiperidine – Pepper • Phragmitescommunis Trin – Phragmites Australis (Cav.) Trin. Ex Steud • Phyllanthus Orbicularis – Phyllanthus Orbicularis Kunth • Pinusolidic Acid – Vanillin & Malonic Acid • Piperettine – Pepper • Pipericide – Pepper • Piperine – Pepper • Piperolein B – Pepper • Poria Cocos Polysaccharide – Poria Cocos(Schw.)Wolf. • Protocatechuic Acid – Stenoloma Chusanum(L.) Ching Leaves • Protopine – Corydalis Yanhusuo W.T.Wang • Quercetin – Sophora Japonica • Quercetin-3-B-Galactoside – St. John’s Wort • Quercetin-3,7-O-Α-L-Dirhamnoside （Quercitrin） – Sabina Pingii Var. Wilsonii • Quinic Acid – Cinchona Bark • Radix Codonopsis Root • Radix Glehniae – Coasiai Giehnia Root • Radix　Platycodonis Platycodigenin, Polygalacic Acid – Platycodon Grandiflorum Root • Radix Scrophulariae Root • Reserpine – Rauvolfia Verticillata (Lour.) Baill. • Resveratrol – Polygonum Cuspidatum • Retrofractamide A – Black Pepper • Rhamnetin – Syzygium Aromaticum • Rhizoma Atractylodis Macrocephalae Root • Rhizoma Pinelliae – Pinellia Ternata (Thunb.) Breit • Rhoifolin – Turpinia Arguya Seem Leaves • Rosmarinic Acid – Rosemary • Rupestonic Acid – Artemisia Rupestris L. • Rutin – Ruta Graveolens L. • Saikosapoins A B C D – Bupleurum (Radix Stellariae) • Salicin – Salix Babylonical Bark • Salidroside, Rosavine, Rosin，Rosarin，Rhodiolin – Rhodiola Rosea • Samarangenin B – Limonium Bicolor (Bag.) Kuntze • Saposhnikovia Divaricata (Trucz.) Schischk Root • Savinin • Schisandrin, Deoxyschisandrin, Neoschisandrin – Schisandra Chinensis • Schizonepeta Tenusfolia Briq Dried Flower • Selaginella Moellendorfii Hieron • Semen Lepidii Semen Descurainiae – Eruca Sativa Mill • Silibinin – Milk Thistle • Silymarin – Milk Thistle • Solanum Rantonnetii Aerial Parts Extact – Lycianthes Rantonnetii Bitter • Somniferine – Ashwagandha/Ajagandha/Kanaje • Stigmasterol – Soybean • Synephrine – Citrus Aurantium Powde • Taxillus Sutchuenensis – Taxillus Sutchuenensis (Lecomte ) Danser • Tinocordifolin – Tinospora Cordifolia • Tinocordifolioside – Tinospora Cordifolia • Tinosporide – Tinospora Cordifolia • Trichostachine – Piper Hancei Maxim • Triterpenoid Saponins – Trichosanthes Kirilowii (Mongolian Snakegourd Fruit) • Umbelliferone – Ruta Graveolens L. • Ursolic Acid – Loquat Leaf • Valinomycin – Bacterium Streptomyces • Verbascum Thapsus L – Mullein • Vicenin – Desmodium Styracifolium • Vincamine – Catharanthus Roseus （L.）G. Don • Vitex Polygama – Vitex Negundo L. Var. Cannabifolia (Sieb. Et Zucc.) Hand.-Mazz • Withaferin A – Ashwagandha • Withanolide – Ashwagandha • Withanolide B – Ashwagandha • Withanone – Ashwaganda • Wogonin – Scutellaria Baicalensis （Radix Scutellariae） • Wrinkled Giant hyssop – Agastache Rugosa (Fisch. Et Mey.) O. Ktze. • Yohimbine – Yohimbe Bark

200:1 CONCENTRATION

very potent

300 1/8 tsp servings per 100g bag.

Take 1/8 – 1/4 serving 2-4 times a day.

ANTIVIRAL EFFECTS OF FLAVONOIDS AND POLYPHENOLS (THOUSANDS OF STUDIES – CLICK TO READ)

May Polyphenols Have a Role Against Coronavirus Infection? An Overview of the Evidence

Overall, this evidence suggests that polyphenols may exert a marked and well-demonstrated activity against coronaviruses, at least in vitro, in addition to the previously demonstrated antiviral activity in vivo. Studies available in the literature agree in establishing that the reduction of virus titer and the inhibition of nucleocapsid protein expression are their main general mechanisms of action at the base of this promising effect of polyphenols. These elucidated mechanisms are of great interest, since nowadays no effective treatments have been licensed, and the development of novel synthetic drugs against specific coronavirus molecular targets are still far from being achieved.

Antiviral effect of flavonoids on human viruses

The effect of several naturally occurring dietary flavonoids including quercetin, naringin, hesperetin, and catechin on the infectivity and replication of herpes simplex virus type 1 (HSV-1), polio-virus type 1, parainfluenza virus type 3 (Pf-3), and respiratory syncytial virus (RSV) was studied in vitro in cell culture monolayers employing the technique of viral plaque reduction. Quercetin caused a concentration-dependent reduction in the infectivity of each virus. In addition, it reduced intracellular replication of each virus when monolayers were infected and subsequently cultured in medium containing quercetin. Preincubation of tissue culture cell monolayers with quercetin did not affect the ability of the viruses to infect or replicate in the tissue culture monolayers. Hesperetin had no effect on infectivity but it reduced intracellular replication of each of the viruses. Catechin inhibited the infectivity but not the replication of RSV and HSV-1 and had negligible effects on the other viruses. Naringin had no effect on either the infectivity or the replication of any of the viruses studied. Thus, naturally occurring flavonoids possess a variable spectrum of antiviral activity against certain RNA (RSV, Pf-3, polio) and DNA (HSV-1) viruses acting to inhibit infectivity and/or replication.

Discovery of anti-2019-nCoV agents toward respiratory diseases via docking screening

The 2019 novel coronavirus (2019-nCoV) causes novel coronavirus pneumonia (NCP). Given that approved drug repurposing becomes a common strategy to quickly find antiviral treatments, a collection of FDA-approved drugs can be powerful resources for new anti-NCP indication discoveries. In addition to synthetic compounds, Chinese Patent Drugs (CPD), also play a key role in the treatment of virus related infections diseases in China. Here we compiled major components from 38 CPDs that are commonly used in the respiratory diseases and docked them against two drug targets, ACE2 receptor and viral main protease. According to our docking screening, 10 antiviral components, including hesperidin, saikosaponin A, rutin, corosolic acid, verbascoside, baicalin, glycyrrhizin, mulberroside A, cynaroside, and bilirubin, can directly bind to both host cell target ACE2 receptor and viral target main protease. In combination of the docking results, the natural abundance of the substances, and botanical knowledge, we proposed that artemisinin, rutin, glycyrrhizin, cholic acid, hyodeoxycholic acid, puerarin, oleanic acid, andrographolide, matrine, codeine, morphine, chlorogenic acid, and baicalin (or Yinhuang Injection containing chlorogenic acid and baicalin) might be of value for clinical trials during a 2019-nCov outbreak.

Antiviral potential of phytoligands against chymotrypsin-like protease of COVID‐19 virus using molecular docking studies: An optimistic approach

A recent outbreak of the novel coronavirus, COVID‐19, in the city of Wuhan, Hubei province, China and its ensuing worldwide spread have resulted in lakhs of infections and thousands of deaths. As of now, there are no registered therapies for treating the contagious COVID‐19 infections, henceforth drug repositioning may provide a fast way out. In the present study, a total of thirty-five compounds including commonly used anti-viral drugs were screened against chymotrypsin-like protease (3CLpro) using SwissDock. Interaction between amino acid of targeted protein and ligands was visualized by UCSF Chimera. Docking studies revealed that the phytochemicals such as cordifolin, anisofolin A, apigenin 7-glucoside, luteolin, laballenic acid, quercetin, luteolin-4-glucoside exhibited significant binding energy with the enzyme viz. – 8.77, -8.72, -8.36, -8.35, -8.13, -8.04 and -7.87 Kcal/Mol respectively. Therefore, new lead compounds can be used for drug development against SARS‐CoV‐2 infections.

Identification of potent COVID-19 main protease (Mpro) inhibitors from natural polyphenols: An in silico strategy unveils a hope against CORONA

COVID-19, a rapidly spreading new strain of coronavirus, has affected more than 150 countries and received worldwide attention. The lack of efficacious drugs or vaccines against SARS-CoV-2 has further worsened the situation. Thus, there is an urgent need to boost up research for the development of effective therapeutics and affordable diagnostic against COVID-19. The crystallized form of SARS-CoV-2 main protease (Mpro) was demonstrated by a Chinese researcher Liu et al. (2020) which is a novel therapeutic drug target.

This study was conducted to evaluate the efficacy of medicinal plant-based bioactive compounds against COVID-19 Mpro by molecular docking study. Molecular docking investigations were performed by using Molegro Virtual Docker 7 to analyze the inhibition probability of these compounds against COVID-19. COVID-19 Mpro was docked with 80 flavonoid compounds and the binding energies were obtained from the docking of (PDB ID: 6LU7: Resolution 2.16 Å) with the native ligand. According to obtained results, hesperidin, rutin, diosmin, apiin, diacetylcurcumin, (E)-1-(2-Hydroxy-4-methoxyphenyl)-3-[3-[(E)-3-(2-hydroxy-4- methoxyphenyl)-3-oxoprop-1-enyl]phenyl]prop-2-en-1-one, and beta,beta’-(4-Methoxy-1,3- phenylene)bis(2′-hydroxy-4′,6′-dimethoxyacrylophenone have been found as more effective on COVID-19 than nelfinavir. So, this study will pave a way for doing advanced experimental research to evaluate the real medicinal potential of these compounds to cure COVID-19.

Potential of Flavonoid-Inspired Phytomedicines against COVID-19

Flavonoids are widely used as phytomedicines. Here, we report on flavonoid phytomedicines with potential for development into prophylactics or therapeutics against coronavirus disease 2019 (COVID-19). These flavonoid-based phytomedicines include: caflanone, Equivir, hesperetin, myricetin, and Linebacker. Our in silico studies show that these flavonoid-based molecules can bind with high affinity to the spike protein, helicase, and protease sites on the ACE2 receptor used by the severe acute respiratory syndrome coronavirus 2 to infect cells and cause COVID-19. Meanwhile, in vitro studies show potential of caflanone to inhibit virus entry factors including, ABL-2, cathepsin L, cytokines (IL-1β, IL-6, IL-8, Mip-1α, TNF-α), and PI4Kiiiβ as well as AXL-2, which facilitates mother-to-fetus transmission of coronavirus.

Recognition of Natural Products as Potential Inhibitors of COVID-19 Main Protease (Mpro): In-Silico Evidences

Since most of the drug candidates presently available for COVID-19 substantially act on viral main protease, by using molecular docking analysis, we have predicted the protease inhibitor activity of several natural products that can emerge as potential drug candidates inhibiting viral protease. A promising binding of natural products with the COVID-19 main protease was revealed by docking analysis. Among the several natural products screened by docking analysis, glycyrrhizin, tryptanthrine, rhein, and berberine were found to exhibit a higher degree of interaction with the viral protease accompanied by lowest binding energy with favorable drug-like properties. Thus these natural products may emerge as potential COVID-19 main protease inhibitor. However, additional exploration is inevitable for the investigation of the inherent use of the herbs containing these natural products and their in-vivo activity.

Targeting SARS-CoV-2 Spike Protein of COVID-19 with Naturally Occurring Phytochemicals

Spike glycoprotein found on the surface of SARS-CoV-2 (SARS-CoV-2S) is a class I fusion protein which helps the virus in its initial attachment with human Angiotensin converting enzyme 2 (ACE2) receptor and its consecutive fusion with the host cells. The attachment is mediated by the S1 subunit of the protein via its receptor binding domain. Upon binding with the receptor the protein changes its conformation from a pre-fusion to a post-fusion form. The membrane fusion and internalization of the virus is brought about by the S2 domain of the spike protein. From ancient times people have relied on naturally occurring substances like phytochemicals to fight against diseases and infection. Among these phytochemicals, flavonoids and non-flavonoids have been found to be the active source of different anti-microbial agents. Recently, studies have shown that these phytochemicals have essential anti-viral activities. We performed a molecular docking study using 10 potential naturally occurring flavonoids/non-flavonoids against the SARS-CoV-2 spike protein and compared their affinity with the FDA approved drug hydroxychloroquine (HCQ). Interestingly, the docking analysis suggested that C-terminal of S1 domain and S2 domain of the spike protein are important for binding with these compounds.

Kamferol, curcumin, pterostilbene, and HCQ interact with the C-terminal of S1 domain with binding energies of -7.4, -7.1, -6.7 and -5.6 Kcal/mol, respectively. Fisetin, quercetin, isorhamnetin, genistein, luteolin, resveratrol and apigenin on the other hand, interact with the S2 domain of spike protein with the binding energies of -8.5, -8.5, -8.3, -8.2, -8.2, -7.9, -7.7 Kcal/mol, respectively. Our study suggested that, these flavonoid and non-flavonoid moieties have significantly high binding affinity for the two main important domains of the spike protein which is responsible for the attachment and internalization of the virus in the host cell and their binding affinities are much higher compared to that of HCQ. In addition, ADME (absorption, distribution, metabolism and excretion) analysis also suggested that these compounds consist of drug likeness property which may help for further explore as anti-SARS-CoV-2 agents. Further, in vitro and in vivo study of these compounds will provide a clear path for the development of novel compounds that would most likely prevent the receptor binding or internalization of the SARS-CoV-2 spike protein and therefore could be used as drugs for COVID-19 therapy.

Roles of flavonoids against coronavirus infection

In terms of public health, the 21st century has been characterized by coronavirus pandemics: in 2002-03 the virus SARS-CoV caused SARS; in 2012 MERS-CoV emerged and in 2019 a new human betacoronavirus strain, called SARS-CoV-2, caused the unprecedented COVID-19 outbreak. During the course of the current epidemic, medical challenges to save lives and scientific research aimed to reveal the genetic evolution and the biochemistry of the vital cycle of the new pathogen could lead to new preventive and therapeutic strategies against SARS-CoV-2. Up to now, there is no cure for COVID-19 and waiting for an efficacious vaccine, the development of “savage” protocols, based on “old” anti-inflammatory and anti-viral drugs represents a valid and alternative therapeutic approach. As an alternative or additional therapeutic/preventive option, different in silico and in vitro studies demonstrated that small natural molecules, belonging to polyphenols family, can interfere with various stages of coronavirus entry and replication cycle.

Here, we reviewed the capacity of well-known (e.g. quercetin, baicalin, luteolin, hesperetin, gallocatechin gallate, epigallocatechin gallate) and uncommon (e.g. scutellarein, amentoflavone, papyriflavonol A) flavonoids, secondary metabolites widely present in plant tissues with antioxidant and anti-microbial functions, to inhibit key proteins involved in coronavirus infective cycle, such as PL^pro, 3CL^pro, NTPase/helicase. Due to their pleiotropic activities and lack of systemic toxicity, flavonoids and their derivative may represent target compounds to be tested in future clinical trials to enrich the drug arsenal against coronavirus infections.

In conclusion, the interest of scientists for the antiviral capacity of flavonoids against human coronavirus infections can benefit of the enormous amount of resources that governments, health agencies, and private companies are pouring in the field, searching for a cure against SARS-CoV-2. This situation barely resembles what happened in the eighties-nineties following the AIDS pandemic, when the basic knowledge in the immunological mechanisms controlling the response to HIV infection underwent amazing and unpredictable progresses. Waiting for a valuable vaccine against COVID-19, the pharmacological approach remains a priority and flavonoids may contribute to it. In this scenario, the “pleiotropic” properties of flavonoids that we mentioned at the beginning of this review, risks to become the passepartout to counteract coronaviruses since they can be effective on both sides, viral and host cells, to inhibit infection. In fact, recent works hypothesized that flavonoids can inhibit both TMPRSS2 and Furin, which cleave the SARS-CoV-2 Spike protein facilitating SARS-CoV-2 infectivity. Molecular docking-based screening and in vitro assays using recombinant proteins indicated that (−)-epicatechin 3-O-(3′-O-methyl) gallate for TMPRSS2 [⁸⁴] and baicalein and oroxylin A glycoside for Furin [⁸⁵] can bind and inhibit their respective proteases blocking virus propagation.

INGREDIENTS & studies

3,2᾿dihydroxyflavone (Trifolium repens L.)

Antiviral activity of 3,4′-dihydroxyflavone on influenza a virus

Influenza virus infection causes thousands of deaths and millions of hospitalizations worldwide every year and the emergence of resistance to anti-influenza drugs has prompted scientists to seek new natural antiviral materials. In this study, we screened 13 different flavonoids from various flavonoid groups to identify the most potent antiviral flavonoid against human influenza A/PR/8/34 (H1N1). The 3-hydroxyl group flavonoids, including 3,2᾿dihydroxyflavone (3,2᾿DHF) and 3,4᾿dihydroxyflavone (3,4᾿DHF), showed potent anti-influenza activity. They inhibited viral neuraminidase activity and viral adsorption onto cells. To confirm the anti-influenza activity of these flavonoids, we used an in vivo mouse model.

In mice infected with human influenza, oral administration of 3,4᾿DHF significantly decreased virus titers and pathological changes in the lung and reduced body weight loss and death. Our data suggest that 3-hydroxyl group flavonoids, particularly 3,4᾿DHF, have potent antiviral activity against human influenza A/PR/8/34 (H1N1) in vitro and in vivo. Further clinical studies are needed to investigate the therapeutic and prophylactic potential of the 3-hydroxyl group flavonoids in treating influenza pandemics.

6-gingerol (ginger extract)

Acidicheterogluca (Tremella fuciformis)

Structure, bioactivities and applications of the polysaccharides from Tremella fuciformis mushroom: A review

Tremella fuciformis is an important edible mushroom that has been widely cultivated and used as food and medicinal ingredient in traditional Chinese medicine. In the past decades, many researchers have reported that T. fuciformis polysaccharides (TPS) possess various bioactivities, including anti-tumor, immunomodulatory, anti-oxidation, anti-aging, repairing brain memory impairment, anti-inflammatory, hypoglycemic and hypocholesterolemic. The structural characteristic of TPS has also been extensively investigated using advanced modern analytical technologies such as NMR, GC–MS, LC-MS and FT-IR to dissect the structure-activity relationship (SAR) of the TPS biomacromolecule. This article reviews the recent progress in the extraction, purification, structural characterization and applications of TPS.

Antitumor and immunomodulatory

In recent years, studies on the mechanism of polysaccharides have shown that polysaccharides have an immunosuppressive activity protecting against tumor growth. TPS exerts anti-tumor activity by promoting the host’s natural immune defenses. These polysaccharides can modulate the body’s immune functions by regulating immune organs, immune cells and immune molecules, and their immune activity without significant side effects [34]. TPS also has the effect of regulating body immunity and inhibiting tumor growth. Its inhibitory effect on tumors is achieved through the intermediate host effect, that is, by enhancing the body’s immune function to a tumor. TPS can inhibit the growth of Hep G22 cells and at concentrations of 50 mg/ml, the antitumor activity can reach 92% [12]. TPS can reduce side effects during treatment of tumors and can enable patients to rebuild their own immune system improving their cancer resistance [35]. Polysaccharides mainly play an immune function through macrophages, and macrophages can respond to infections, tumors and inflammation.

Macrophages directly kill pathogens through phagocytosis and present antigens to elicit an immune response [36]. Macrophages produce a large number of biologically active molecules, including nitric oxide (NO), reactive oxygen species (ROS), and cytokines including tumor necrosis factor TNF-α, interleukin (IL)-1α, IL-1β, for defense of IL-6, IL-10 [37]. TPS can reverse the effect of proliferation and polarization of CD4+ T cells in Pseudomonas aeruginosa infected scald mice, resulting in a decline in the level of IL-10 [38]. TPS can inhibit modulate cyclophosphamide-induced mouse leukopenia. Leukocytes increase in a dose-dependent fashion [39]. Cyclophosphamide significantly reduces the mRNA expression of IL-1β, IL-4 and IL-12 in liver and spleen, and significantly increases the expression of TGF-β in liver and spleen. CY significantly reduces serum immune organ index and serum cytokine levels (IL-2, IL-12, INF-γ, and Ig G) and increases serum TGF-β levels. These results suggest that low-dose TPS has no obvious effect,

Aconitum carmichaelii

Antiviral activity of aconite alkaloids from Aconitum carmichaelii Debx

Four diterpenoid alkaloids, namely, (a) hypaconitine, (b) songorine, (c) mesaconitine and (d) aconitine, were isolated from the ethanol root extract of Aconitum carmichaelii Debx. The antiviral activities of these alkaloids against tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV) were evaluated. Antiviral activity test in vivo showed that compounds a and c, which were C19-diterpenoid alkaloids, showed inactivation efficacy values of 82.4 and 85.6% against TMV at 500 μg/mL, respectively.

By contrast, compound c presented inactivation activity of 52.1% against CMV at 500 μg/mL, which was almost equal to that of the commercial Ningnanmycin (87.1% inactivation activity against TMV and 53.8% inactivation activity against CMV). C19-Diterpenoid alkaloids displayed moderate to high antiviral activity against TMV and CMV at 500 μg/mL, dosage plays an important role in antiviral activities. This paper is the first report on the evolution of aconite diterpenoid alkaloids for antiviral activity against CMV.

Ailanthus altissima

Virus-Cell Fusion Inhibitory Compounds from Ailanthus altissima Swingle

In order to search for the anti-HIV agents from natural products, eighty MeOH extracts of medicinal plants were applied to a syncytia formation inhibition assay which is based on the interaction between the HIV-1 envelope glycoprotein gp120/gp41 and the cellular membrane protein CD4 of T lymphocytes. Among them, Ailanthus altissima showed a potent virus-cell fusion inhibitory activity.

allantoin (Glyoxylic acid)

Alphitonia philippinensis

Flavonol glycosides derived from the stems of Alphitonia philippinensis have been reported to inhibit the replication of HSV-1.

Three new flavonol glycosides, namely, isorhamnetin 3-O-(6″-O-(Z)-p-coumaroyl)-β-d-glucopyranoside, quercetin 3-O-α-l-rhamnopyranosyl(1-2)-α-l-arabinopyranosyl(1-2)-α-l-rhamnopyranoside, and quercetin 3-O-α-l-arabinopyranosyl(1-2)-α-l-rhamnopyranoside, were isolated from the stems of Alphitonia philippinensis collected from Hainan Island, China. Some of the isolated triterpenoids and flavonoid glycosides showed cytotoxicity against human PC-3 cells and hepatoma HA22T cells, and the inhibition of replication on HSV-1 (131). Viral diseases, especially of skin, can be treated with a virucide encapsulated in multilamellar phospholipid liposomes. Rosmarinic acid (70), incorporated in phospholipid mixture demonstrated effectiveness in humans afflicted with HSV (132). Flavonol glycosides (from quercetin and isorhamnetin) derived from the stems of Alphitonia philippinensis have been reported to inhibit the replication of HSV-1.

Amygdalin (Semen Armeniacae Amarum)

Amygdalin could Inhibit IFN-γ, NF-κB and NLRP3 signaling pathways so as to reduce the inflammatory response (Paoletti et al., 2013; Zhang et al., 2017). These reports provided the scientific ground of integrating TCM therapy from the aspects of their compositions’ potential targeting proteins and signaling pathways in the treatment of COVID-19.

Anemarrhena asphodeloides

Anti-respiratory syncytial virus (RSV) activity of timosaponin A-III from the rhizomes of Anemarrhena asphodeloides

Two known steroidal saponins, timosaponin A-III (1) and anemarsaponin B (2) were isolated from the BuOH fraction of the rhizomes of Anemarrhena asphodeloides Bunge (Liliaceae) together with the xanthone derivatives, mangiferin (3) and neomangiferin (4). Structures of the isolates were identified using 1D and 2D NMR techniques and by comparison with the published values. Timosaponin A-III (1) exhibited potent inhibitory effects on the respiratory syncytial virus (RSV), with an IC₅₀ value of 1.00 µM.

Angelica sinensis

Angelica sinensis may provide protection against human immunodeficiency virus infection

Increased oxidative stress and disturbed glutathione redox system play an important role in the pathogenesis of human immunodeficiency virus (HIV) infection. Depletion in intracellular levels of reduced glutathione (GSH) contributes to an increment in tumor necrosis factor α (TNF-α)-stimulated-HIV-1-transcription, activation of HIV-1-replication, sensitivity to TNF-α-induced cell death, and impairment of CD4+ cell function and survival. Therefore, several studies have investigated the effect of GSH-enhancer agents such as N-acetyl cystein in the treatment of patients with HIV infection. With regard to the beneficial effects of Angelica sinensis, a Chinese medicinal herb, on GSH redox system and the pathogenic role of GSH depletion in HIV infection and the immunomodulator effects of active ingredients of this herb, we postulated that Angelica sinensis may be of value in the treatment of HIV-infected patients.

Apigenin (celery extract)

Targeting SARS-CoV-2 Spike Protein of COVID-19 with Naturally Occurring Phytochemicals

Apigenin has shown potent antiviral activity against hepatitis B virus, adenoviruses, african swine fever virus and some RNA viruses in vitro.

arctigeNin, arctin (Arctium Lappa)

Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus

Arctiin and its aglucone, arctigenin from the fruits of Arctium lappa L. showed potent in vitro antiviral activities against influenza A virus (A/NWS/33, H1N1) (IFV). Based on the data from time-of-addition experiments and on release tests of progeny viruses, arctigenin was assumed to interfere with early event(s) of viral replication after viral penetration into cells, and to suppress the release of progeny viruses from the host cells. Arctiin was orally effective against either IFV-inoculated normal or 5-fluorouracil (5-FU)-treated mice, being less effective as compared with oseltamivir.

Noticeably, arctiin produced a larger amount of virus-specific antibody than those of control and oseltamivir in sera collected from 5-FU-treated mice. Furthermore, oral treatment of 5-FU-treated mice with arctiin did not induce any resistant viruses, although the same treatment with oseltamivir induced resistant viruses at a 50% frequency. When the combination of arctiin and oseltamivir was administered to normal mice infected with IFV, the virus yields in both bronchoalveolar lavage fluids and lungs were significantly reduced relative to those in the mice treated with arctiin or oseltamivir alone. Thus, monotherapy of arctiin or combined therapy of arctiin with oseltamivir would be another treatment option for influenza.

artemisinin (Artemisia annua)

Discuss about the application of Artemisia annua prescriptions in the treatment of COVID-19

The applications of traditional Chinese medicine (TCM) have been playing an important role in treating the epidemics of Coronavirus Disease 2019 (COVID-19), which is now prevalent all over the world. Exploring the mechanisms of TCM compound prescriptions might be difficult though, pharmacological studies on elucidating the effective components of TCM could serve as the experimental basis in the application of TCM compound prescription in treating COVID-19. As the critical active ingredients of Qinghao (Artemisia annua), artemisinin was initially used as antimalaria drug.

Artemisia annua prescriptions take significant effect against pneumonia. Sharing similarities in pharmacology with artemisinin, chloroquine has been confirmed effective in inhibiting Severe Acute Respiratory Syndrome coronavirus 2 (SARS-Cov-2) both in vitro and practically. In this context, we discussed the application of Artemisia annua prescriptions against COVID-19 along with the antiviral effect of chloroquine.

Conclusion

With similar pharmacological effects between chloroquine and artemisinin in treating infectious diseases, this paper discusses the modern scientific basis for the application of Artemisia annua prescriptions in COVID-19. Except for antimalarial, most of the other pharmacological studies on artemisinin and its derivatives are still on the bench or at animal level, with only a few in clinical trials. Artemisinin treatment on COVID-19 has not been reported yet. As a treasure of TCM, compound prescription has played an important role in plagues in history. The main cause of COVID-19 in Wuhan is damp-heat according to TCM theory. The prescription for clearing heat and eliminating dampness based on Artemisia annua is widely used in this epidemic. Based on the antiviral and anti-inflammatory effects of artemisinin and its derivatives, Artemisia annua prescriptions have great value to dig into and are promising to be used in more infectious diseases. But more in vitro experiments need to be carried out to provide more evidence, such as the influence of Artemisia or Artemisia annua prescriptions on inflammatory factors express

aspalathin

Aspalathus Linearis (Burm.f.) R. Dahlrgen (Rooibos)

Aspalathin and nothofagin extracted from Rooibos have been shown to effectively inhibit LPS-induced release of HMGB1, and suppressed HMGB1-mediated septic responses, such as hyperpermeability, adhesion and migration of leukocytes, and expression of cell adhesion molecules [124]. These molecules, as part of ethanol and alkaline extracts of the Rooibos plant, have also been shown to reduce Influenza A viral load at a late stage of the infection in vitro [125].

atractylodin (Areactylodis Lanceae)

Antiviral activities of atractylon from Atractylodis Rhizoma

Atractylodis Rhizoma is a traditional medicinal herb, which has antibacterial, antiviral, anti-inflammatory and anti-allergic, anticancer, gastroprotective and neuroprotective activities. It is widely used for treating fever, cold, phlegm, edema and arthralgia syndrome in South-East Asian nations. In this study, 6 chemical compositions of Atractylodis Rhizoma were characterized by spectral analysis and their antiviral activities were evaluated in vitro and in vivo. Among them, atractylon showed most significant antiviral activities. Atractylon treatment at doses of 10–40 mg/kg for 5 days attenuated influenza A virus (IAV)-induced pulmonary injury and decreased the serum levels of interleukin (IL)-6, tumor necrosis factor-α and IL-1β, but increased interferon-β (IFN-β) levels.

Atractylon treatment upregulated the expression of Toll-like receptor 7 (TLR7), MyD88, tumor necrosis factor receptor-associated factor 6 and IFN-β mRNA but downregulated nuclear factor-κB p65 protein expression in the lung tissues of IAV-infected mice. These results demonstrated that atractylon significantly alleviated IAV-induced lung injury via regulating the TLR7 signaling pathway, and may warrant further evaluation as a possible agent for IAV treatment.

Baicalein (Scutellaria baicalensis)

benzaldehyde (Laurus nobilis)

Berberine (Coptis chinensis)

Beta-sitosterol

BS has been shown to act as a powerful immune modulator [134]. BS exhibits immune-modulating activities in HIV-infected patients [135]. It has also been reported that BS targets specific T-helper (Th) lymphocytes, increasing Th1 activity and improving T-lymphocyte and natural killer (NK) cell activity [135,136]. In another study it was observed that BS maintains stable CD 4 cell counts in AIDS, declines apoptosis of CD 4 lymphocytes slightly, thereby slowing HIV. A significant decrease in IL-6 levels in the same study leads to a further claim that there is slowing down of viral replication rates in infected cells thereby decreasing viral load [137]. Neurath et al. (2005) proposes BS as an envelope virus neutralizing compound (EVNC) and thus acting as an HIV-1 entry inhibitor [138].

This claim has been substantiated by the fact that the EVNCs in the body fluid neutralize viruses in the blood stream and elicit an immune response to the neutralized authentically folded virus particle [139,140]. Even though the effect of BS on entry and exit out of the cell is not available, it is evident that BS facilitates the development of a potentially protective immunity against HIV. However, further study for considering BS as potential therapeutic agent has not progressed. Therefore, extensive study is suggested.

Betulinic acid (Betula platyphylla)

Bisdemethoxycurcumin (turmeric)

Brachyamide B (Piper boehmeriaefolium)

Broussonetia papyrifera

Identification of polyphenols from Broussonetia papyrifera as SARS CoV-2 main protease inhibitors using in silico docking and molecular dynamics simulation approaches

bulbocapnine (Corydalis decumbens)

caffeic acid

Calanolide A (Calophyllum lanigerum)

Campesterol (Rapeseed oil)

Carvacrol (Oregano)

Antiviral activity of the Lippia graveolens (Mexican oregano) essential oil and its main compound carvacrol against human and animal viruses

Mexican oregano (Lippia graveolens) is a plant found in Mexico and Central America that is traditionally used as a medicinal herb. In the present study, we investigated the antiviral activity of the essential oil of Mexican oregano and its major component, carvacrol, against different human and animal viruses. The MTT test (3–4,5-dimethythiazol-2yl)-2,5-diphenyl tetrazolium bromide) was conducted to determine the selectivity index (SI) of the essential oil, which was equal to 13.1, 7.4, 10.8, 9.7, and 7.2 for acyclovir-resistant herpes simplex virus type 1 (ACVR-HHV-1), acyclovir-sensitive HHV-1, human respiratory syncytial virus (HRSV), bovine herpesvirus type 2 (BoHV-2), and bovine viral diarrhoea virus (BVDV), respectively.

The human rotavirus (RV) and BoHV-1 and 5 were not inhibited by the essential oil. Carvacrol alone exhibited high antiviral activity against RV with a SI of 33, but it was less efficient than the oil for the other viruses. Thus, Mexican oregano oil and its main component, carvacrol, are able to inhibit different human and animal viruses in vitro. Specifically, the antiviral effects of Mexican oregano oil on ACVR-HHV-1 and HRSV and of carvacrol on RV justify more detailed studies.

Chavicine (black pepper)

chelidimerine (Chelidonium majus)

chlorogenic acid

Chrysin (Pinus monticola)

Cinnamomum cassia bark

Cirsilineol (Cirsium lineare)

Cirsimaritin (Rabdosia eriocalyx)

cis-capsaicin (civamide)

colchicine (Colchicum autumnale)

Cordifolioside A (Viola verecunda)

Crategolic acid (Loquat leaf)

Curcumin (Turmeric Root)

Cycloastragenol (Astragalus membranaceus)

dehydrogingerdione (ginger extract)

Dendrobium nobile

Demethoxycurcumin

Dianthus caryophyllus

Dioscin (Dioscorea oppositae)

Douchi (Sojae Praepatum)

Egcg (green tea extract)

Emodin (Rhubarb extract)

Eriodictyol (lemon extract)

Eugenitin (clove extract)

ferruginol (PodocarpuS ferruginea)

Fisetin (Rhus succedanea)

Flavonol glucoside (Trichilia connaroides)

forskolin (Coleus Forskohlii)

Fructus Perillae

fumarophycine (Laptopyrum Reichb)

galangin (Alpinia officinarum)

gallic acid (Rheumpalmatum)

Genistein (Genista tinctoria)

Glycyrrhizic acid (licorice root)

gossypol (cotton seed)

Guineensine (Piper longum)

GYPSUM FIBROSUM extract

Hawthorn Extract

herbacetin (flaxseed)

Hesperetin (Citrus Aurantium)

hesperidin
(Pericarpium Citri Reticulatae Extract)

SARS-CoV-2 or COVID-19 is representing the major global burden that implicated more than 4.7 million infected cases and 310 thousand deaths worldwide in less than 6 months. The prevalence of this pandemic disease is expected to rise every day. The challenge is to control its rapid spread meanwhile looking for a specific treatment to improve patient outcomes. Hesperidin is a classical herbal medicine used worldwide for a long time with an excellent safety profile. Hesperidin is a well-known herbal medication used as an antioxidant and anti-inflammatory agent. Available shreds of evidence support the promising use of hesperidin in prophylaxis and treatment of COVID 19.

Herein, we discuss the possible prophylactic and treatment mechanisms of hesperidin based on previous and recent findings. Hesperidin can block coronavirus from entering host cells through ACE2 receptors which can prevent the infection. Anti-viral activity of hesperidin might constitute a treatment option for COVID-19 through improving host cellular immunity against infection and its good anti-inflammatory activity may help in controlling cytokine storm. Hesperidin mixture with diosmin co-administrated with heparin protect against venous thromboembolism which may prevent disease progression. Based on that, hesperidin might be used as a meaningful prophylactic agent and a promising adjuvant treatment option against SARS-CoV-2 infection.

Hesperidin and SARS-CoV-2: New Light on the Healthy Functions of Citrus Fruit

Among the many approaches to COVID-19 prevention, the possible role of diet has so far been somewhat marginal. Nutrition is very rich in substances with a potential beneficial effect on health and some of these could have an antiviral action or in any case be important in modulating the immune system and in defending cells from the oxidative stress associated with infection. This short review draws the attention on some components of Citrus fruits and especially of the orange (Citrus sinensis), well known for its vitamin content, but less for the function of its flavonoids. Among the latter, hesperidin has recently attracted the attention of researchers, because it binds to the key proteins of the SARS-CoV-2 virus.

Several computational methods, independently applied by different researchers, showed that hesperidin has a low binding energy both with the coronavirus “spike” protein, and with the main protease that transforms the early proteins of the virus (pp1a and ppa1b) into the complex responsible for viral replication. The affinity of hesperidin for these proteins is comparable if not superior to that of common chemical antivirals. The preventive efficacy of vitamin C, at dosage attainable by diet, against viral infections is controversial, but recent reviews suggest that this substance may be useful in case of increased stress on the immune system. Finally, the reasons that suggest undertaking appropriate research on the Citrus fruits addition in the diet, as a complementary prevention and treatment of COVID-19, are discussed.

himachalol (Cupressus funebris)

honokiol (Magnolia officinalis)

houttuynia cordata

Hypericin (Forsythia suspensa)

isoliquiritigenin (glycyrrhiza uralensisfisch)

Isopiperine (pepper extract)

Isothymonin (Kaempferia galanga)

Jatrorrhizine (Phellodendron amurense)

Jujuboside A+B (Jujube extract)

Kaempferol (kaempferol galanga)

Kaempferol 3-O-robinobiosid

leachianone (Morus alba)

Lepidium meyenii (maca extract)

Lily Extract (Lilium auratum)

luteoforol (a flavan-4-ol

Luteolin

LUTeolin specifically binds to the surface spike protein of SARS‐Cov‐2 and inhibits entry of the virus into host cells.

The new coronavirus (severe acute pulmonary syndrome [SARS]‐CoV‐2) originated in China, where it spread rapidly,1 and has reached pandemic proportions because of its high rate of infectivity as well as high morbidity and mortality, associated with COVID‐19.2 This coronavirus infects by first binding to the ectoenzyme angiotensin‐converting enzyme 2 (ACE₂),3, 4 a serine protease acting as the receptor, while another serine protease is necessary for priming the viral “S” protein required for entering the cells.5 Defense against the virus apparently does not involve inflammatory cytokines,6 but pulmonary infection and its serious sequelae result from the release of multiple chemokines and cytokines that damage the lungs.

A recent report correlated coronaviruses infection with activation of mast cells and subsequent cytokine storms in the lungs.7Mast cells are known to be triggered by viruses.8 Mast cells are unique immune cells that are ubiquitous in the body, especially the lungs,9 and are critical for allergic and pulmonary diseases,10 including mastocytosis11 by secreting histamine, leukotrienes, and proteases. Mast cells are also involved in the development of inflammation12 via release of multiple pro‐inflammatory cytokines and chemokines.13, 14

Mast cells contain the serine protease ACE₂, which can convert angiotensin I into angiotensin II.15 In addition to the bronchoconstrictive action of mast cell‐derived leukotrienes, mast cells cause further bronchoconstriction via an active renin‐angiotensin generating system in the lungs.16Moreover, mast cells express a number of serine proteases,17 especially the mast cell‐serine protease tryptase,18 which are necessary for infection by SARS‐CoV‐2. A serine protease inhibitor, camostat mesylate, was recently shown to prevent entry of the virus into the lung cells of SARS‐CoV‐2‐infected patients.19 It would be important to not only inhibit entry of SARS‐CoV‐2 but also prevent SARS associated with COVID‐19.

The possible use of nonsteroidal anti‐inflammatory agents has come into question for possibly aggravating pulmonary symptoms,20 while broad‐spectrum immune suppressors, such as corticosteroids,21 would not be advisable given that an intact immune system is necessary to fight the infection and it may even lead to increased plasma viral load.22

Inhibition of mast cell‐associated inflammation could be accomplished with natural molecules, especially the polyphenolic flavonoids.23 The flavone luteolin (not lutein, which is a carotenoid) has been shown to have broad antiviral properties.24–26 Luteolin specifically binds to the surface spike protein of SARS‐Cov‐2 and inhibits entry of the virus into host cells.27 Furthermore, luteolin inhibits serine proteases,28 including the SARS‐CoV 3CL protease29 required for viral infectivity.

Moreover, luteolin inhibits mast cells30, 31and has anti‐inflammatory properties.32 A novel luteolin analogue, tetramethoxyluteolin, is even more potent32 and can also inhibit secretion of the pro‐inflammatory cytokines TNF and IL‐1β,33, 34 as well as the chemokines CCL2 and CCL535 from human mast cells.

Lycoris radiata

Macaranga barteri

In Vitro Antiviral Activity Of Twenty-Seven Medicinal Plant Extracts From Southwest Nigeria Against Three Serotypes Of Echovirus es

Maclura cochinchinensis

Magnoflorine (Thalictrum aquilegifolium)

Marrubium peregrinum L (Lamiaceae)

Meliacine (Melia azedarach)

Mint extract

morroniside (Cornus officinalis)

myricetin (black Bayberry)

naringenin (Amacardi-um occidentale)

ndoxyl-β-glucoside (Isatis indigotica)

nothofagin (Aspalathus Linearis)

Oleanolic acid (olea europaea)

ophiocarpine (Corydalis ophiocarpa)

ophiopogonin A (Ophiopogon Root)

Orientin (Globeflower Extract)

Elucidating The Effects Of Orientin And Madecassoside On Saffold virus Infection In Bv2 Microglial And Ne-4C Neural Stem Cells

oxypeucedanin
(Angelica dahurica Extract)

paeoniflorin (Radix Paeoniae)

Patrinia villosa

pectolinarin (Linaria vulgaris)

Pelargonium sidoides (Pelargonium peltatum)

Pentadienoylpiperidine

Phragmitescommunis

Phyllanthus orbicularis

Piperettine (pepper extract)

Piperine / Pipercide (pepper extract)

Piperolein b (pepper extract)

Poria Cocos

protocatechuic acid (Stenoloma chusanum)

protopine (Corydalis yanhusuo)

Quercetin (sophora japonica)

Quercetin-3-b-galactoside

quercetin-3,7-O-α-l-dirhamnoside

In Vitro And In Silico Study To Evaluate The Effectiveness Of Quercitrin As Antiviral Drug To Dengue virus

Human adenovirus (HAdV)-36 is one of the viruses that are known to cause infectobesity in humans. Unlike extensive research on preventing obesity and developing anti-obesity drugs, little research has been conducted specifically on the prevention and treatment of infectobesity. Therefore, this study aimed to evaluate the effects of phytochemicals from D. racemosum on the replication of HAdV-36. A549 cells infected with HAdV-36 were treated with an ethyl acetate fraction of a D. racemosum leaf extract (DRE), and the virus titer was calculated based on the hemagglutination (HA) titer.

The results showed a concentration-dependent inhibitory effect of DRE treatment on HA titers. DRE treatment was also found to inhibit the cytopathic effects of the virus and the expression of viral genes. Quercitrin was identified as the constituent of DRE exerting an inhibitory effect on HAdV-36 replication. This study shows that DRE can be used as a candidate substance for the development of treatment for HAdV-36 infections. In addition, this study provides a basis to further investigate DRE for the development of anti-infectobesity medication

quinic acid (Cinchona bark)

Radix Codonopsis

Radix Glehniae (CoasiaI GIehnia)

Radix Platycodonis (Platycodon grandiflorum)

Radix Scrophulariae

Reserpine (Rauvolfia verticillata)

Resveratrol (Polygonum cuspidatum)

Retrofractamide A

Rhamnetin (Syzygium aromaticum)

Rhizoma Atractylodis Macrocephalae

Rhizoma Pinelliae (Pinellia ternata)

rhoifolin (Turpinia arguya)

Rosmarinic acid (rosemary)

rupestonic acid (Artemisia rupestris)

Rutin (Ruta graveolens)

saikosapoins (Bupleurum)

Salicin (Salix babylonicaL)

Isolation of Salicin Derivatives from Homalium cochinchinensis and Their Antiviral Activities

Salidroside (Rhodiola Rosea)

Salvadora persica

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

In December 2019, an outbreak of coronavirus disease 2019 (COVID-19) commenced in Wuhan, China and affected around 210 countries and territories in a matter of weeks. It has a phylogenetic similarity to SARS-CoV and it was named coronavirus 2 (SARS-CoV-2) and caused severe acute respiratory syndrome that could lead to death. One of the promising therapeutic strategies for virus infection is the search for enzyme inhibitors among natural compounds using molecular docking in order to obtain products with minimal side effects. COVID-19 virus main protease plays a vital role in mediating viral transcription and replication, introducing it as an attractive antiviral agent target. Metabolic profiling of the aqueous extract of Salvadora persicaL. (Salvadoraceae) aerial parts dereplicated eleven known flavonol glycosides using LC-HRESIMS.

All the annotated flavonoids exhibited significant binding stability at the N3 binding site to different degrees, except isorhamnetin-3-O-β-D-glucopyranoside, when compared with the currently used COVID-19 main protease inhibitor, darunavir. Structural similarity between the identified flavonoids enabled the study of the relationship between their structure and interactions with the receptor in the N3 binding site of the COVID-19 main protease. The results indicate that the basic flavonol nucleus possesses activity itself. Moreover, the presence of a rutinose moiety at the 3 position of ring C and absence of an O-methyl group in ring B of the flavonol structure could increase the binding stability. This study provides a scientific basis for the health benefits of the regular use of S. persica as it leaches bioactive flavonoids in the aqueous saliva.

samarangenin B (Limonium bicolor)

Saposhnikovia divaricata

sarracenia purpurea

schisandrin (Schisandra chinensis)

Schizonepeta tenusfolia

Selaginella moellendorffii

Semen Lepidii (Eruca sativa Mill)

Silibinin (Milk Thistle Extract)

Silymarin (Milk Thistle Extract)

Solanum rantonnetii

Potent Antiviral Activity Of Solanum Rantonnetii And The Isolated Compounds Against Hepatitis C virus In Vitro

SOmniferine A (Ashwaganda)

Evaluation of Traditional Ayurvedic Preparation for Prevention and Management of the Novel Coronavirus (SARS-CoV-2) Using Molecular Docking Approach

Since the emergence of novel Coronavirus (SARS-CoV-2) infection in Wuhan, China in December 2019, it has now spread to over 205 countries. The ever-growing list of globally spread corona virus-19 disease (COVID19) patients has demonstrated the high transmission rate among human population. Although 12 new drugs are being tried for management of COVID19, currently there are no FDA approved drugs or vaccines to prevent and treat the infection of the SARS-CoV-2. Considering the current state of affairs, there is an urgent unmet medical need to identify novel and effective approaches for prevention and treatment of COVID19 by re-evaluating the knowledge of traditional medicines and repurposing of drugs. Here, we used molecular docking approach to explore the beneficial roles of an array of phytochemicals and active pharmacological agents present in the Indian herbs (Tulsi, Haldi, Giloy, Black pepper, Ginger, Clove, Cardamom, lemon, and Ashwagandha) which are widely used in the preparation of Ayurvedic medicines in the form of Kadha to control various respiratory disorders such as cough, cold and flu. The evaluation was made based on the docking scores calculated by AutoDock Vina. Our study has identified an array of phytochemicals present in these herbs which have significant docking scores and potential to inhibit different stages of SARS-CoV-2 infection as well as other Coronavirus target proteins.

Molecular docking also indicated that, the phytochemicals present in these herbs possess significant anti-inflammatory property. Overall our study provides scientific justification in terms of binding of active ingredients present in different plants used in Kadha preparation with viral proteins and target proteins for prevention and treatment of the COVID19. This preparation can boost individual’s immunity and inhibit the viral severity by interfering at different stages of virus multiplication in the infected person. Our study predicts that an array of the phytochemicals such as Withaferin A, Withanolide B, Withanolide, Withanone, Campesterol, Cyclocurcumin,Somniferine A,Stigmasterol, Eriodictyol, Isopiperine, Oleanolic acid, Rhamnetin, Orientin, Quercetin, Piperine, Vicenin etc. found in the preparation of the Kadha, have significant binding affinity with the many of these inflammatory mediators or the molecules involved in this process (Table 7). It is well known that, NF-κB is the master regulator for several genes such as COX-2, VEGF (vascular endothelial growth Factor), proinflammatory cytokines (IL-1, IL-2, IL-6, and TNFα), chemokines (e.g., IL-8, MIP-1α, and MCP1), adhesion molecules, immunoreceptors, growth factors, and other agents involved in proliferation and invasion. NF-κB activation is mediated by two distinctly different redoxrelated signalling pathways. The first pathway involves NIK/IKK whereas second pathway involve MAPKs and both causes the induction of transcriptional activation of NF-κB. NF-κBinducing kinase (NIK) is a key mediator of the non-canonical NF-κB signalling pathway. NF-κB is also one of the main inducible transcription factors shown to respond directly to oxidative stress.

Oxidative stress activates nuclear factor-inducing kinase (NIK)/IκB kinase (IKK) and mitogen-activated protein kinases (MAPKs). NIK/IKK and MAPK pathways activate NF-κB and migrates to the nucleus and binds to κ elements on DNA in enhancers and promoter regions. Various herbs have potential to control inflammation-associated disease by decreasing the production of the pro-inflammatory mediators by suppressing pro-inflammatory pathways (Pan et al., 2011). Our study also predicted that phytochemicals found in the Kadha have significant binding affinity with NIK (Table 7) which can stop NF-κB mediated downstream events. In a very recent study, Huang et al (2020) have shown that the patients infected with SARS-CoV-2 had high amounts of IL1, IFNγ, IP10, and MCP1, which can mediate cytokine storm associated multi-organ damage. At the same time, SARS-CoV-2 infection also initiates increased secretion of T-helper-2 (Th2) cytokines (eg, IL4 and IL10) which suppress inflammation (Huang et al., 2020). The increased secretion of inflammatory mediators was also associated with moderation of helper T cell responses in COVID19 patients.

Sars-cov-2 host entry and replication inhibitors from Indian ginseng: an in-silico approach

Withania somnifera (Solanaceae) (L.) Dunal, popularly known as ‘Ashwagandha’ and ‘Indian Ginseng’ is a prime medicinal plant of Ayurvedic and indigenous medicines from India and has been used as an herbal tonic and healthy food to treat various kinds of diseases and human ailments (Gurav & Gurav, 2014). W. somnifera contains alkaloids, flavonoids and steroidal lactones namely withanine, somniferine, somnine, somniferinine, withananine, pseudowithanine tropane, pseudo-tropine, choline, anaferine, anahydrine, isopelletierine, withaferin A and B, 27-deoxywithaferin, dihydrowithaferin A, 17-hydroxywithaferin A, withanolide A, B, C, D, E, G, J, L, M, N, O, P, Q, R and S, withanone, withanosine II, III, IV, V, VI, X and XI, Quercetin, and Quercetin-3-O-galactosyl-rhamnosyl-glucoside (QGRG; Abraham et al., 1968; Elsakka et al., 1990; Gupta & Rana, 2007; Krison & Glotter, 1980; Matsuda et al., 2001). Ashwagandha is widely claimed to have hepatoprotective, anxiolytic, antidepressant, nootropic, antimicrobial, anti-inflammatory, antioxidant, anti-stress, anticonvulsant, cardio-protective, antitumor, anti-genotoxic, anti-Parkinson and immunomodulatory properties (Dar et al., 2015; Gurav et al., 2020).

Stigmasterol (soybean)

St. Rophanthus Gratus

Solid evidence- ouabain is an effective therapeutic for the treatment of COVID-19

Worldwide efforts are underway to find therapeutics for the treatment of covid-19.. In several test series, ouabain has been identified as a highly active antiviral agent. Ouabain (known as g-Strophanthin in German) has been used successfully for decades in the treatment of heart disease, particularly in Germany. Extensive clinical experience with this active ingredient is available. These also include experience with infectious diseases. As early as 1933, Fraenkel pointed out the successful treatment of pneumonia with Ouabain. “Since the large doses (of Strophanthin ) have become commonplace in pneumonia, the acute heart failure peculiar to it has lost its terror.” [1] In 1960, Walter Neugebauer reported, “In acute circulatory failure and infectious diseases, Strophanthin will probably be hard to do without.” [2]

Antiviral effects of Ouabain.

Current research findings confirm these clinical experiences. Ouabain has pronounced antiviral effects. In several series of tests, cardiac glycosides have been identified as highly active antiviral compounds. Digoxin, digitoxin, and ouabain which are known drugs for therapy of heart disease, show efficacy against a broad spectrum of viruses in vitro and in vivo. Digoxin and ouabain also have excellent effects against SARS-CoV-2 viruses at nanomolar concentrations [3-7]. Viral titers after single-dose treatment with ouabain and digoxin showed >99% inhibition of SARS-CoV-2 replication. When administered in the post-entry phase, ouabain and digoxin significantly inhibited viral mRNA expression and protein expression. When administered in the host entry phase of the viral cycle, digoxin shows no effective antiviral activity. In contrast, ouabain inhibits approximately 50% of viral mRNA expression and protein expression even at the entry stage [6].

In a recent paper, a US research group led by Harvey Pollard has been able to show that the cardiac glycosides ouabain, digitoxin and digoxin block the entry of SARS-CoV-2 spike-pseudotyped viruses into human lung cells, thereby preventing the infectivity of native SARS-CoV-2 [8]. Cardiac glycosides block the binding reaction between ACE2 and the viral spike (S) protein, preventing virus entry into target cells. The authors conclude from their research that “Ouabain, digitoxin and digoxin competitively inhibit ACE2 binding to the SARS-CoV-2 Receptor Binding Domain (RBD), and block virus penetration and infectivity in human lung cells.” It is therefore possible to use these drugs for COVID- 19 therapy.”

synephrine (Citrus Aurantium)

Taxillus sutchuenensis

Tinocordifolin (Tinospora cordifolia)

Tinocordifolioside (Tinospora cordifolia)

Tinosporide (Tinospora cordifolia)

Trichostachine (Piper hancei)

Triterpenoid saponins

Umbelliferone (Ruta graveolens)

Ursolic acid (Loquat Leaf)

Verbascum thapsus (Mullein Extract)

Vicenin (Desmodium styracifolium)

vincamine (Catharanthus roseus)

Vitex polygama

Withaferin A, b (Ashwagandha)

Withanone (Ashwagandha)

Withanone from Withania somnifera May Inhibit Novel Coronavirus (COVID-19) Entry by Disrupting Interactions between Viral S-Protein Receptor Binding Domain and Host ACE2 Receptor

Newly emerged COVID-19 has been shown to engage the host cell ACE2 through its spike protein receptor binding domain (RBD). Here we show that natural phytochemical from a medicinal herb, Withania somnifera, have distinct effects on viral RBD and host ACE2 receptor complex.

Methods: We employed molecular docking to screen thousands of phytochemicals against the ACE2-RBD complex, performed molecular dynamics (MD) simulation, and estimated the electrostatic component of binding free energy, along with the computation of salt bridge electrostatics.

Results: We report that W. somnifera compound, Withanone, docked very well in the binding interface of AEC2-RBD complex, and was found to move slightly towards the interface centre on simulation. Withanone significantly decreased electrostatic component of binding free energies of ACE2-RBD complex. Two salt bridges were also identified at the interface; incorporation of Withanone destabilized these salt bridges and decreased their occupancies. We postulate, such an interruption of electrostatic interactions between the RBD and ACE2 would block or weaken COVID-19 entry and its subsequent infectivity.

Conclusion: Our data, for the first time, show that natural phytochemicals could well be the viable options for controlling COVID-19 entry into host cells, and W. somnifera may be the first choice of herbs in these directions to curb the COVID-19 infectivity.

Wogonin (Scutellaria baicalensis)

Korean Mint (Wrinkled Giant hyssop)

yohimbine

Mandatory FDA Warning: As with any supplement, consult your medical practitioner prior to using this product if you are pregnant, may become pregnant, breastfeeding, taking medication, other dietary supplements or have a medical condition. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. *Daily Value has not been established.

Size	50g, 100g, 200g, 300g

26 reviews for VICTORIOUS : Science Based Anti Viral Formula 200:1

Rated 5 out of 5
Rich Ryan – August 14, 2020
Wow!
I had all the C0VID-19 symptoms (didn’t get tested, don’t want to get tracked) and upon starting a tsp a day of Victorious, all the symptoms were gone within 2 days!
I felt better and was able to goto work within about 4 hours. Amazing stuff!
With this and keto diet and intermittent fasting, there’s no need to worry about the big bad virus!
I’ve been taking it for about 4 weeks so far, and have also noticed that my skin is getting much smoother.
Nice Side Effect!
Rated 5 out of 5
Andy Williams – August 23, 2020
I’ve been using the blends for about a month now, Trinity, Seven Sages and Victorious and they are next level!
I have been taking mine in coffee with a keto diet. I stopped taking other supplements to test the effectiveness and they are nothing short of amazing. Insane energy and mental clarity and focus, waking up easier and when I added in Victorious my skin was NOTICEABLY more consistent and evenly toned, within DAYS.
I’m feeling very healthy all round. Prior to taking the blends I was already feeling great physically and mentally before starting so I was skeptical if I would feel much from the blends but let me say I feel even more amazing and they work FAST!
I did a loading phase at the start so I would personally just order the bigger sizes if you’re needing to load up for the first few days. The herbs do what Gavin says they do so you can have confidence in getting the larger amount. Just read the reviews, it’s all there or reach out to Gavin he will help you out no problem. It took around a week or so to really start feeling the effects and once they came on I backed off to the recommended amounts for maintenance which is more than enough.
Gavin has put together some pretty damn sweet blends and I’ll be using them for a long time! Don’t wait, invest in yourself and your health. It’s worth it.
Rated 5 out of 5
Abram Armas – October 1, 2020
I had all the common symptoms of Covid, the loss of taste smell and an awfully high fever that was getting worst. I felt completely fatigued and not able to function and not getting any better.
After introducing the anti viral blend I almost immediately that same day saw my symptoms improving. My fever was coming down, my nose congestion was going away, by the third day I was able to do my normal day to day tasks without the fatigue and the ill feeling.
I’m so grateful for Gavin, for putting this amazing blend together It has truly helped me tremendously In improving my symptoms and beating Covid.
Rated 5 out of 5
Andy Williams (verified owner) – October 9, 2020
Updated Victorious Review 🙂
I started taking Victorious because I got a sizeable sample with an order that I did and loved it so ordered more. One thing I noticed was that it almost immediately started clearing up my skin and “purging” my body from within.
It makes me feel incredibly healthy and gives me more energy. Some of the effects are immediate and some come on over time so it’s one to stay on for a while to get even greater benefits as you go.
It’s definitely one of the most powerful blends and you don’t need a lot to get the benefits.
My skin has totally transformed after months of use. Clearer, better complexion and tans better and more evenly. My overall vitality has definitely increased also.
Also one of the other benefits at higher dosages I felt “lean and dry” and not bloated at all. Mindset, athletic performance and health are improved.
This is WAY more than just an anti viral!! Get some!
Rated 5 out of 5
Alecxander Castro – October 14, 2020
I first heard from Interstellar blends from Shaun Lee on Instagram. I hesitated cuz of the price but after a few months I dove in and got every single product from Gavin to see which one was best for my lifestyle.
I work in a hedgefund so I need to have my brain on point all the time and I found that my favorite herbs were: Apigenin, Shilajit, Victorious, Peel, Spice, ALZ, Luteolin, Hypnotic to sleep, Super Tonic Hair, and Pine Pollen. I take them pure with hot water.
I lead a pretty active and healthy lifestyle and I found that combining these blends with my morning green shake of veggies and fruits, my cognitive functions and my brain in general works so much better. It even helps me to meditate more deeply and productively. They will be in my arsenal of tools to boost my brain. The more you use Apigenin, the more brain cells you form in your brain cuz of neuro genesis. How cool is that! If I understand it correctly, you get smarter by every month using it while leading a healthy lifestyle!
Rated 5 out of 5
Taranjit Virk – November 15, 2020
Review for Victorious:
I started to feel a little under the weather with a sore throat and headache I usually always get sick around this time as the weather starts to change. I decided to take Victorious after reading so many reviews on it and man they were not lying!! Within minutes after taking Victorious with warm water my symptoms started to disappear. Definitely buying again and passing this product on to friends and family!
Rated 5 out of 5
Cindy Smith (verified owner) – December 1, 2020
I had been visiting/staying with my dad while he was in a hospital rehab situation when he was diagnosed with Covid. Although I was feeling just fine, I had a Covid test, and my doctor also ordered the flu test. Well, I tested negative for Covid but positive for flu type A! I wonder why my mask did not keep me from getting the flu…hmmm…….
Anyway… I had just recently started taking some of the blends (Super Nova, Peel, Super Hair, Thermo, Pine Pollen) and immediately started mega dosing on the sample of Victorious I had received, as well as increasing my dosage of Peel. (Thank you so much for that sample of Victorious, Gavin!) I did not have any Spice on hand, but nonetheless I never did get really sick. The day after I was diagnosed I was a little achy in the morning, but by late afternoon that was gone. The third day I was nauseous with diarrhea, which I felt was my body disposing of the virus. Days 4 thru 6, I was just feeling a little tired, but no other symptoms. By day 7, I was back to normal. I never had any respiratory distress, coughing or congestion…nothing at all in my head and lungs.
I am convinced that the blends I had just recently started taking had already enhanced my immunity, and then starting with 1/2 tsp Victorious twice/day and increasing Peel accordingly that the flu was stopped dead in its tracks!
I am always going to have Victorious, Peel and Spice on hand for illness defense! Thank you, Gavin…I’m so glad I found your products!
Rated 5 out of 5
Trinity Blackwell – December 18, 2020
Wow. Victorious is amazing and I haven’t even ot used it on myself yet. Three months ago I brought home 3 rescue puppies, one of whom had a swollen face and swollen and weepy eyes. She also had multiple hard lumps in her ears, about which the vet couldn’t give me any insight. The prescription eye cream could only be used for a couple weeks and then the eye issues returned. I emailed Gavin and he suggested trying Victorious with her food. Within 3 days her eyes were better. If I skip a couple days it starts to return, so I don’t skip anymore. This morning I noticed that there’s only one tiny ear lump left, I’m sure soon to be gone. Amazing bonus! I’m so grateful. I feel like I’m prepared for anything now, with Victorious added to my home emergency supplies.
Rated 5 out of 5
Shirley Oey (verified owner) – December 21, 2020
Gavin sent me a free Victorious blend to try in November. While waiting for delivery, my cousin Elly called to tell me she got COVID. She is a nurse in a nursing home. She was having fevers and chills. I sent her the Victorious blend, By the time she received it, she had already vomiting.
I told her to take the blends immediately.
My goodness, she did so well she went back to work about 2 weeks later. I’m just sooooo happy we didn’t loose Elly. Thank you so much Gavin!! You saved her life!!
I’m been doing very well taking Victorious blend also. I work in the grocery store 40 hours a week while in low dose chemotherapy treatments for stage 4 breast cancer. My white blood count goes down to below normal levels.
I know the blend helps me from getting COVID.
Thank you again for creating this awesome blend.
Rated 5 out of 5
Stephen Shuman – December 31, 2020
I have been a loyal customer for years now, and once again I am shown outstanding evidence that your blends go above and beyond to protect my body. Last Saturday I was at my friends after Christmas party. It was a potluck style party where everyone brought in their Christmas left overs. Additionally there was a beautiful giant hooka set up. I’d say there were probably 20+ people there, and I thoroughly enjoyed myself. Yesterday morning I started getting reports that people were not feeling well and went to get tested, and over 75% the people there tested positive, but I was not one of them. I was not wearing a mask while I was there. I shared the hooka while I was there. I also shared drinks while I was there. I did everything that people say guarantees a covid infection. I got the regular PCR test which is 99% effective and a day later saw my negative results. Every day I take Luteolin, Victorious and Peel blends and during fasting and keto I take Trinity and Senolytics. I am 100% confident that my daily use of Gavin’s blends besides keeping me healthy in every way that matters, also protected me against a covid infection. Thank you very much Gavin!!!
Rated 5 out of 5
Kyra V – February 7, 2021
I tested positive for COVID right after Christmas. My symptoms were fairly minimal, but I lost my taste and smell, fatigue, and I ran a low fever for a day. My sister recommended victorious to me based on the reviews she had read. I ordered a sample to try and my symptoms were gone within a week. I was able to return to work without any difficulties the next week.
I don’t know if this is an additional side effect, but I have also struggled with systemic acne since adolescence. After taking victorious, I noticed that my acne has started to clear as well. Like I said, I don’t know if this is an official effect, but taking victorious is the only thing in my diet that has changed. I have tried countless cleansers and medications throughout my life and I am so happy that this is a healthier alternative to medications and chemicals used to clear acne.
After having so much success, I got some for my grandparents to take to help protect them during COVID. They have taken it and have not been sick with even a cold this season and they have reported higher energy levels and an overall improvement in how they are feeling. Needless to say,I am a believer and I will continue to tell everyone about victorious because it works!
Rated 5 out of 5
Lewis M (verified owner) – March 23, 2021
wow. this stuff is amazing, I have been reading reviews on these blends for a few months now and thinking to myself is it actually true. I decided to bite the bullet and order some victorious blend. What a delight I was in for, I brought a small package and received a free sample with my parcel that I am yet to try but im sure I will love. I just had to come back and right my review for victorious first.
working outside as a blockpaver in the uk I face a lot of weather trouble and most of the time during winter I feel run down and tired and always have a cold of a chesty cough. however after using victorious for a little under 2 weeks now ive never felt this energetic and healthy during the winter months before. usually after working in the cold all day I come home and shower and sleep but now I feel ready to take on more tasks because I don’t feel run down or ‘under the weather’. I used it in black coffee every morning and afternoon. recently I have started the dry fast that is recommended with the blends and that’s a whole different story.
I have heard about fasting before but I always thought this was for people who didn’t burn much energy during the day at work. having a very labour intense job I always though that it wasn’t possible to fast all day without consuming calories/energy. However after doing some research into ‘dry fasting’ I though why not give it a go and see how I feel. During the first day I felt hungry but that was my body jut getting used to this new plan. I had one black coffee with the blend in the morning and one just after lunch to keep my energy up at work. after day 2 I didn’t have any of the cravings for snacks or food like I normally do during work and went right through the day without any food and only a small amount of water. and I can honestly say I feel amazing I am now ready to look into the other blends and see where they take me to. very excited to get started with some of the others.
Rated 5 out of 5
Sudevika Okeahi (verified owner) – June 9, 2021
I bought several months worth of this Victorious blend and am absolutely stoked!
I’m taking it with Autonomous, Spice and Peel blends twice daily.
I haven’t felt better in my entire life.
These blends are priceless!
I wish more people knew about them the world would be a healthier and happier place.
I started off with Spice and Peel Blends over two years ago for chronic back and knee pains with complete relief after. I’ve now added Victorious and Autonomous to the mix this year and it’s like the entire army is protecting and nourishing my mind and body.
Things I was being told for years I had to live with and just cover with horrible medications that only caused nasty side effects and hardly gave me any relief are now completely gone and or totally maintained through taking these blends daily. I can’t say enough how grateful and thankful I am. I highly recommend to anyone reading this to try them for yourselves! You truly have nothing to lose and everything to gain!
Thank you again!
Rated 5 out of 5
Lexi (verified owner) – August 17, 2021
I first ordered a few blends in February this year. Since starting blends and following 22/2 protocol I have noticed so many positive changes in my overall fitness and health. I quickly found I loved Trinity, Autonomous and Luteolin so much I was ready to try some additional blends.
I decided to order Spice and Peel too. Since taking these blends and following 22/2 I have noticed improvements to my skin and I have no joint inflammation. A couple of months later, after seeing such great results, I decided to look at VICTORIOUS. Mainly because I do not intend to get the Covid vaccine. I messaged Gavin to ask if I should only take it if I’m feeling run down. He replied straight away, like always, that he takes it every day and it works well with Spice and Peel to help skin as well. I started to take it everyday and my skin has been amazing since! So much fresher and glowing and rarely a spot! I have had so many compliments and it is a massive confidence boost!
I give my children victorious when they are feeling run down or if they have a cold. They always seem to get them very mildly and improve quickly. I have found so far that I haven’t been ill since taking blends and fasting. Even when the kids have had colds I haven’t caught them.
During a recent holiday I relaxed the fasting, didn’t eat too well and was also relaxed about taking my blends. I regretted it after as my skin and joints definitely suffered! Back on 22/2 protocol and blends. Spice, Peel and Victorious have made my skin glow again. I noticed such a difference after starting spice and peel but victorious definitely seals the deal for me.
I now have tried most of Interstellar blends and they have all helped so much. I am medication free, previously I took medication for chrons disease and citalopram for depression. I very slowly weaned off off the citalopram and Gavin offered me advice to help me through the horrible withdrawal effects which I had even from just the very low dose I had been taking!! Now medication free for a few months and I couldn’t be happier about that!
Gavin posts so much research on his site and the information available is incredible to aid self healing. I’m so happy to have been introduced to blends. Feel fitter and healthier than I did even in my early 20s and I’m late 30s now! Definitely a customer for life.
Rated 5 out of 5
Allie T – October 5, 2021
First, let me preface by saying that I’ve been using these blends for a couple of years and they are simply amazing overall. They have healed so many things for me. I’m 58 years old, cancer survivor(wish I knew about these blends then..would have taken an entirely different direction with treatment for sure!!), was overweight–the blends have changed my life! So now on to Victorious…
I, like many of us that take the blends, didn’t take the covid vaccination (we can save that whole thing for another day, but suffice to say–and to quote the Rolling Stones–“what if the cure is worse than the disease?”). On Wednesday 9/27 I tested positive for covid(I was supposed to fly internationally so had to take the test). Yes, I had symptoms (bit of a sore throat, cough, aches), nothing earth shattering. I didn’t blink an eye. I upped my peel and spice doses and opened up the SAMPLE pack of Victorious that Gavin and team had put into one of my orders many months ago. I began taking that (along with other blends) 3 times a day, 1/4 teaspoon each dose.
The outcome? Im writing this review 6 days later, but felt 100% better THREE DAYS after starting Victorious. There is no more virus in my body. I feel great and was at the gym 4 days after that positive test. All I know is that, while others are losing their minds over this thing, we (those of us taking the blends) just flow along knowing we are protected from all of it(flus, colds, covid, etc). Blends, eating sensibly once a day ( or, in my case, once every other day). And if you find yourself in a health situation, be strong and confident that Interstellar Blends has you covered!
Rated 5 out of 5
Alejandro Ayala (verified owner) – October 21, 2021
A good friend of mine shared me the details of the Interstellar Blends, especially since he’s been on these blends for a long while. Later on, I contacted Gavin about what blends to take for certain things. He quickly responded back, in which I really appreciate. I ordered the Victorious, Peel, and Spice.
Man, I’m telling you, when the first time I tried Peel & Spice, I was starting to have a lot of energy within 15-20 minutes. Then, I took a dosage of Victorious, and it added more energy throughout my day. I took these on a empty stomach in the morning & wasn’t hungry for long hours later. Even when I did my second dosage of these blends, I still wasn’t hungry. I usually take other herbs for years, but I usually end up eating shortly after. However, these blends help me fast for longer periods of time.
It was perfect timing when I received these blends, especially when I made a couple orders around the same time, so I gave some packs to my mom. She was really sick at the time, so when I received my orders, she immediately took Victorious. She started to feel way better within a couple days. Plus, she didn’t feel the need to eat much after her first dosage in her mornings. She gradually start taking Peel & Spice, and was getting lots of energy while recovering. She eventually became fine quickly.
As for me, as I mentioned, I was getting lots of energy & less cravings for food. My skin has been getting more clear & my hair keeps growing faster than usual, including my nails. Even though I never have issues with my hair & nails, but it’s really interesting how fast they grow after taking these blends. Also, I was surrounded by sick people, especially in close contact, and I was still good & protected. There was a point I forgot to take my Victorious blend later in the year & wasn’t on it for a while due to traveling & forgot to take it with me. After a while, I was having some allergies. So when I arrived back later on to get my Victorious blend, I immediately start taking it again, and my symptoms lessened quickly & eventually went away.
I’m grateful for these blends, and of course I’m definitely a repetitive customer. Thank you Gavin for your creation & energy!
Rated 5 out of 5
Lara (La) Sohn – November 9, 2021
I have / actually now HAD Covid19 Delta variant LONG version. It has been the most traumatic experience I honestly think I’ve ever had. I was taken by ambulance to the ER after taking Ivermectin. It lowered my sodium levels so much I could have seized. I was also put on oxygen. Recovery was a complete nightmare until I started taking Victorious along with Luteolin and Supernova. Upon doing so, I started feeling a change and BETTER within hours! Four days later and I have no brain fog and feel NORMAL again after 4 weeks down- MIRACULOUS!! So much gratitude Gavin!! Absolutely cannot thank you enough for what doctors could not do <3
Rated 5 out of 5
Jade A. – December 7, 2021
This is another excellent blend! Ok so I ended up getting Covid. At first it was strep then it morphed somehow into Covid (who knows though…the test is less than 50% accurate). I suppose my immune system was weakened by the strep since this all happened back to back. My dad lives with me. He works at the hospital so he was exposed and got sick at the same time my son and I did.
I have a history of asthma and this went into my lungs. It was really scary. Not only that before I got the Victorious blend I had a fever of a little over 103 for more than two weeks (my son got over being sick very quickly..he was on other blends that I was taking too). The weirdest part was the fever was mainly in the back of my neck. I had chills, body aches, a vice grip feeling on my lungs( apparently from fluid build up) coughing, and more. It was awful and I was desperate.
I take herbs and am into the natural way of healing…so I remembered Gavin had come out with the Victorious Anti-Viral blend. His blends were life changing for me so I got some and finally the fever lessened within the first day to 100.9!!! By the second day it was down to 99! By the third day I had no fever. Thanks to this blend. You have no idea how grateful I was. I almost went to the hospital because I didn’t know what to do! I wish I hadn’t waited so long to get the Victorious blend!! It has been a bit of a long recovery. But the Victorious blend has helped me sooo much keeping my immune system boosted while I am healing (my lungs were filled with fluid so it is taking a bit). Also my son has hung out with some friends recently and they were sick and I had him take the Victorious blend. He didn’t get sick at all. My dad also got Covid. He believes in more conventional methods of treatment so he got the monoclonal antibodies and refused taking any herbs. Well he wasn’t getting better like he thought he would. He saw me recover quickly after taking the Victorious blend so I convinced him to try it. The same thing happened to him. The fever started to lower and was completely gone by the third day. He said it will now be his go to if he starts to get sick. I tell everyone about it because it works so well!! If I could give 10 stars I would!
Rated 5 out of 5
Natalie Patricia Meyle – December 22, 2021
I was given a small amount of Victorious from my daughter as I had been spending a lot of time with people that had been double whakked. I feel the best I have in years and im getting on 7 Decades around the sun. I wish i had starting using these blends earlier. Lookig forward to getting to know more of these products and there benifits.
Rated 5 out of 5
Jennifer K (verified owner) – August 24, 2022
I have been taking blends for 1 year. Totally love it!
On any flu or Covid19 infection, I take Victorious. Half tsp day and night, all symptoms gone in 3 days. My dad of 89 years old took Victorious, the next day no more running nose and sneezing. He is out once all the symptoms are gone. Every time, I gave him the blends. He literally disappeared from the house for hours!!
Love the knowledge that Gavin is sharing with the community. I have learned so much and the blend change how I live my life and in food consumption. I am living my Best Life now. I like to thank Gavin for sharing with us this amazing product.
– JK (Aug2022)
Rated 5 out of 5
Luis Chavez – November 29, 2022
Well where can I even start? I sat on the side lines for many years just observing Interstellar Blends by recommendation of Shaun Lee. I watched Gavin’s movement before I ever considered pulling the trigger. It wasn’t until I saw that he had remedies for psoriasis which is what I have been suffering from for a few years now so I figured hey this is my chance! I pulled the trigger and it has been the best decision I have ever made!! No regrets whatsoever
To begin I started off with stomach reset combo and let me just say it has been a game changer for me. In just the short amount of time of me trying it out I saw more positive results in a week than any cleanse/ diet I have been on the last couple years. The alleviation my stomach felt was next to none and don’t even get me started on that PURGE!! Feel the burn baby it takes a lot of mental strength for these powerful blends but in time you too will feel invincible using them. What’s quite amazing is that months after the stomach reset you still feel the effects and how much it has changed your body. Foods that used to be really hard to digest for me became a thing of ease. It was almost like I hopped into a whole new body.
After this amazing cleanse I tapped into all the other blends and I just have to say I CANNOT just choose one they’re all so exquisite in their own ways. From someone that has dealt with addictive personality issues these blends have completely transformed my way of being I am much more calm and collective now. I do have to give a standing ovation to a few particular blends however those would be SPICE-PEEL-TRINITY-REWIRE- VICTORIOUS
These blends have absolutely transformed me as a human being and have made my relationship with my psoriasis condition so much better. It hasn’t gone away completely but these blends fight and they fight hard!! They have managed to give me more progress than anything any hospital or clinic could possibly offer me. The amount of relief and satisfaction I get out of life makes these blends so worth it. Whether you’re dealing with any mental issues or physical or you simply want to live better. INTERSTELLAR BLENDS is the ultimate championship elixir of life just scoop some of those magical blends into a perfectly brewed cup of coffee and enjoy the ride! I feel absolutely proud to be part of this movement of fasting and achieving optimal health because at one point I just wanted to give up.. now that I know about these blends my life has forever changed. Thank you Gavin for all your hard work 💯 BAAAMMM!!!
There is so much more to be said about each individual blend but that would take an entire book to write! In a few words I’d describe the blends as
LIFE SHAPING
SACRED
HOLY
POWERFUL
WORLD CLASS
ALLEVIATING
POWERFUL
Rated 5 out of 5
Sunday Elerson – January 31, 2023
◦ I’ve been an Interstellar costumer for 6 years. I typically make 3-4 purchases per year. These blends are an essential part of my life. When I started I used Trinity, Thermo, Matcha and Seven Sages. This combination set me up for successful 22/2 and a weight loss of 37 pounds in about 2 months. Anxiety was a thing of the past, as was obsessing over food. At the age of 44 I had more energy than I had in my 20’s and 30’s. Now I am in my 50’s and I have no problem running to emergencies at work, where some 20 years younger tell me they can’t run to emergencies and be effective.
◦ In the 6 years as a customer, Gavin is constantly outdoing himself and always tackling issues that the others are years behind or even speak about. He was at least 2 years before others to address senescence and create the most effective senolytic out there. He was talking about ice baths before many had a clue what they were and the benefits. If you want to be ahead of the game, Gavin is your resource!
◦ Recently my granddaughter got chicken pox, about 3 days into the virus and a good breakout (I wanted her to have good immunity) I gave her 1/16 tsp of Victorious 3X and she healed up in record time. We kept waiting for the older one to break out but realized that she drank the youngest special drink, thus never got the virus despite eating and drinking after her sister.
◦ In my current interstellar arsenal I have: Victorious, Plush, Thermo, Senolytic, Glucose Blocker, Apigenin, Autophagy, Anti-Adipogenic, Super Hair, Niagra, Shilajit and Pine Pollen.
◦ I will always be an interstellar customer. The customer service is the best of any company I have ever dealt with.
◦ Sunday E.
Rated 5 out of 5
Giannina Winter (verified owner) – May 30, 2023
I am taking the blends now around 2 years and my psoriasis is gone. Of course you need to take care about a good diet but I love Victorious blend so much. I like to combine it with peel & Spice. My all time daily favorites. Also my parents are taking the blends now and I am very happy that they support my family and beloved ones.
Rated 5 out of 5
Giannina Winter (verified owner) – May 30, 2023
It’s been about two years since I started incorporating blends into my diet, and I couldn’t be happier with the results. Not only has my psoriasis disappeared, but I’ve also gained a love for the Victorious blend. Pairing it with peel & Spice has become my daily go-to, as these two blends have quickly become my all-time favorites. I’m especially grateful to see my parents now taking the blends and supporting the health of our entire family. It’s wonderful to witness the power behind a good diet and quality supplements – and I’m simply in love with the blends that have made it all possible.
Rated 5 out of 5
Tamala Bell (verified owner) – September 13, 2023
All I can say is that this is a virus-fighting powerhouse!
So, a couple of days ago, my throat was itching, and the next day, I had a full-blown cold, a runny nose, congestion, and my head felt like it wanted to explode! So I used over-the-counter medications like Alka-Seltzer Cold Plus severe and Theraflu. I used it for two days, and each time it just alleviated my symptoms for an hour. How about that?
So, after testing for COVID, which was happily negative, I tested twice because I had it and the symptoms were the same, but it was not COVID (thanking GOD). So I ask Gavin (who is ALWAYS ready to answer any of my questions or worries; he’s fantastic) how I can take Victorious for a cold, and he responds with one teaspoon a day in grapefruit juice. I answered okay, and he added I could break it up into half a teaspoon in the morning and half a teaspoon at night, to which I said, “Great, thank you.” So on day three of my cold, I take Victorious in the morning, and two hours later I have no headache. The next day, I take the Victorious at night, and the congestion starts to break up. On day four, I wake up feeling almost 100% better. Mind you, this has only been one full day of taking the blend. On day four, I take it in the morning, my nose stops running, and I’m feeling a lot better. Day five, I’m like 100% better. So that’s three days on Victorious, and I’m completely over my cold!
I’m very glad I had this blend in my pantry. Victorious is an unstoppable antivirus blend, and it will always be a staple in my cabinets or freezer! I’m not going to take the over-the-counter nonsense that wrecks your kidneys and everything else. Gavin, thank you so much for taking the time to address all of my worries and questions, because you know I have 101. LOL
Rated 5 out of 5
jcastrillon08@gmail.com (verified owner) – September 28, 2023
Im a registered NURSE and i work all day from 7am to 7pm in the E.R . So this was one of the main blends that i needed to have in my little cabinet. My immune system has not been as strong as it usually is in the past years after i got covid so i made sure to get this blend. Upon taking this blend after fasting because i was so sick i also have a little 3 year old and every time she would get sick i would get sick right after and it was really starting to bug me so i did a loading phase for 2 weeks and i started to notice that i would have more energy and that if i did get sick i would recover much faster.
I also gave this blend to my mom to try for a few days when she would come down with something and she too also noticed that her recovery time was much faster which is amazing. I take this blend normally when im not feeling well along with some extra vitamin C, but i think i will soon be ordering the peel blend as it also helps to make your immune system stronger. Another blend that i have my eye on is lung power since i did have covid i think it will be proactive for me to have this blend handy, specially since winter is right around here in new york.
My immune system feels much stronger now specially after doing the extended fast, thats when i truly noticed the effects if this potent blend and i can not wait to have more blends at hand not only for myself but for my loved ones. I also practice yoga and mindful thinking because i believe all of those components play a role in ones health. Im so happy to have been able to find these blends, happy and very gratefu!!!

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