FOR LONGER DRY FASTS 3+ DAYS (preparation) ALKALINIZE As the dry fast progresses urine ph will drop and continue to drop until you break fast. (Ketone bodies are acidic in nature.) ALWAYS, ALWAYS, ALWAYS alkalinize urine before and again after TO PROTECT KIDNEYS AND AVOID KIDNEY STONES. This is easily accomplished by drinking 1 teaspoon of baking soda in 8oz water. *IF you foolishly skip this step don't cry about getting a kidney stone or having kidney pain in the group as you were STRONGLY WARNED TO ALKALINIZE and dissolve all acid formed crystals in urinary tract before hand. WHY USE BAKING SODA FOR PREVENTING KIDNEY STONES OR KIDNEY PROBLEMS? Because it works and fast! I recommend raising urine ph to an 8 NOT 7 as in study before long dry fasts and once again after. PH STRIPS TO TEST URINE: HERE Conclusions: Bicarbonate therapy remains an attractive option for the treatment of radiolucent kidney stones. The presence of hyperuricaemia or hyperuricosuria appears to influence the success rate. Further prospective randomised studies are needed to identify the most tolerable and effective treatment regime as well as the optimal duration of treatment. Dual-energy CT may hold the key to identifying patients most likely to benefit from treatment. SOURCE: HERE CELLULAR ELECTRICITY I recommend "charging" cells with trace minerals via Fulvic acid. Use either Shilajit or Fulvic mineral source. Without electricity you have no energy. WATCH light bulb demo: HERE AMPK ACTIVATORS/ MTOR INHIBITORS I always utilize before hand to jump start the process SUPERTONIC HERBS that activate AMPK and inhibit mTOR and promote autophagy like what's in Interstellar Blend and Thermogenesis. THIRST AND HEAT The body heats up the longer you go because the cells are incinerating junk via autophagy. Thirst may become intense. I recommend ICE BATHS & ICE SHOWERS to cool down and keep going. You will find this blissfully rejuvenating. STUDY THIS POST AND THE LINKS. The more informed you are the less fear you will have and the greater resolve to not quit. DEHYDRATION WORRIES Skin tenting purportedly begins at 15% body water loss. At 7 days I had zero skin tenting still. NOBODY in group is in danger of dehydration in 72 hours. Nobody. Unless maybe you are in Death Valley, CA in 120+ degree heat sitting there sweating. ****IF YOU GOT FAT YOU GOT WATER.**** So have ZERO FEAR of going 3 days your first time. Alkalinize and launch! What is skin tenting or skin turgor test??? Explained HER BLOOD PRESSURE CONCERNS Be not overly concerned by blood pressure irregularities; the body as it acclimates itself to survival conditions corrects itself the longer you go. It may fluctuate up and down the first 3 days but by day 4 and onward it stabilizes. Blood pressure and resting pulse without fail on all extended dry fasts (beyond 3 days) goes down and this is very positive. Have no fear or worries; perfectly natural process. BUT WHAT ABOUT GLUCOSE REQUIREMENTS ON A
FASTING AND STEM CELL REGENERATION fasting downregulates a IGF-1/PKA pathway in stem cells Prolong fasting protects hematopoietic cells from chemotoxicity Prolonged fasting cycles promote HSC self-renewal to reverse immunosuppression Inhibition of IGF-1 or PKA signaling mimics the effects of prolonged fasting Immune system defects are at the center of aging and a range of diseases. Here, we show that prolonged fasting reduces circulating IGF-1 levels and PKA activity in various cell populations, leading to signal transduction changes in long-term hematopoietic stem cells (LT-HSCs) and niche cells that promote stress resistance, self-renewal, and lineage-balanced regeneration. Multiple cycles of fasting abated the immunosuppression and mortality caused by chemotherapy and reversed age-dependent myeloid-bias in mice, in agreement with preliminary data on the protection of lymphocytes from chemotoxicity in fasting patients. The proregenerative effects of fasting on stem cells were recapitulated by deficiencies in either IGF-1 or PKA and blunted by exogenous IGF-1. These findings link the reduced levels of IGF-1 caused by fasting to PKA signaling and establish their crucial role in regulating hematopoietic stem cell protection, self-renewal, and regeneration. SOURCE: HERE METABOLIC TRIGGERS OF AUTOPHAGY In isolated cells, autophagy is generally induced by limitations in ATP availability or a lack of essential nutrients, including glucose and amino acids (i.e. FASTING or KETOGENIC diet). SOURCE: HERE (CONTINUED IN THE NEXT BLOG "RAMADAN IS DAILY INTERMITTENT DRY FASTING")
FASTING AND CARDIO-PROTECTION HORMESIS What's that? To understand dry fasting (deliberate dehydration and starvation) is to understand hormesis. "That which doesn't kill you makes you stronger." — Nietzsche "All things are poison and nothing is without poison; only the dose makes a thing not a poison." —Paracelsus Even water and oxygen in excess can be deadly; as can their absence. What we are doing is deliberately stressing the body— to make it more resilient. "Hormesis is a biological phenomenon whereby a beneficial effect (improved health, stress tolerance, growth or longevity) results from exposure to low doses of an agent that is otherwise toxic or lethal when given at higher doses." Too much dry fasting can kill just as over eating or over drinking can kill. We are in a sense flexing our cells "muscles"; making them extremely adaptable and tough. "No water? No food? No problem. Wake me up when we got a real crisis on our hands." All about hormesis HERE ***INSULIN BLOCKS SIRT1*** SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), referring to the fact that its sirtuin homolog (biological equivalent across species) in yeast (S. cerevisiae) is Sir2. SIRT1 is an enzyme that deacetylates proteins that contribute to cellular regulation (reaction to stressors, longevity). A major cause of aging is thought to result from the cumulative effects of cell loss over time. In yeast, caloric restriction (CR) delays aging by activating the Sir2 deacetylase. Here we show that expression of mammalian Sir2 (SIRT1) is induced in CR rats as well as in human cells that are treated with serum from these animals. Insulin and insulin-like growth factor 1 (IGF-1) attenuated this response. SIRT1 deacetylates the DNA repair factor Ku70, causing it to sequester the proapoptotic factor Bax away from mitochondria, thereby inhibiting stress-induced apoptotic cell death. Thus, CR could extend life-span by inducing SIRT1 expression and promoting the long-term survival of irreplaceable cells. SOURCE: HERE (CONTINUED IN THE NEXT BLOG TITLED "FASTING AND STEM CELL REGENERATION")
EXERCISE The type of exercise I recommend is of short duration and peak intensity. No lolly gagging! Hour or less. Legs one day; upper body next. Too much exercise is not good and prematurely wears the body out. Intense in and out. Cardio ideas: Sprints are wonderful. Swimming laps are great as well as stationary bike intervals 10 seconds (peak exertion) LEVEL 10 followed by 50 seconds (rest) LEVEL 1 for 15-20 cycles. AMPK ACTIVATION AND INTENSE INTERVAL EXERCISE "Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1 in human skeletal muscle In summary, the present study showed that four 30-s bouts of all out cycling increased phosphorylation of AMPK 1, AMPK 2, and p38 MAPK immediately following exercise and the mRNA expression of PGC-1 after 3 h of recovery. Specific signaling through AMPK and p38 MAPK to PGC-1 may therefore explain in part the metabolic remodeling in- duced by intense interval exercise training, including mitochondrial biogenesis and an increased capacity for glucose and fatty acid oxidation." SOURCE: HERE LEUCINE ACTIVATES mTOR and thus increases protein synthesis so it can be used to accelerate muscle growth AT BEGINNING of exercise window "We recently showed that resistance exercise and ingestion of essential amino acids with carbohydrate (EAA+CHO) can independently stimulate mammalian target of rapamycin (mTOR) signaling and muscle protein synthesis in humans. Providing an EAA+CHO solution postexercise can further increase muscle protein synthesis. Therefore, we hypothesized that enhanced mTOR signaling might be responsible for the greater muscle protein synthesis when leucine-enriched EAA+CHOs are ingested during postexercise recovery. Sixteen male subjects were randomized to one of two groups (control or EAA+CHO). The EAA+CHO group ingested the nutrient solution 1 h after resistance exercise. mTOR signaling was assessed by immunoblotting from repeated muscle biopsy samples. Mixed muscle fractional synthetic rate (FSR) was measured using stable isotope techniques. Muscle protein synthesis and 4E-BP1 phosphorylation during exercise were significantly reduced (P < 0.05). Postexercise FSR was elevated above baseline in both groups at 1 h but was even further elevated in the EAA+CHO group at 2 h postexercise (P < 0.05). Increased FSR was associated with enhanced phosphorylation of mTOR and S6K1 (P < 0.05). Akt phosphorylation was elevated at 1 h and returned to baseline by 2 h in the control group, but it remained elevated in the EAA+CHO group (P < 0.05). 4E-BP1 phosphorylation returned to baseline during recovery in control but became elevated when EAA+CHO was ingested (P < 0.05). eEF2 phosphorylation decreased at 1 and 2 h postexercise to a similar extent in both groups (P < 0.05). Our data suggest that enhanced activation of the mTOR signaling pathway is playing a role in the greater synthesis of muscle proteins when resistance exercise is followed by EAA+CHO ingestion." SOURCE: HERE (CONTINUED IN THE NEXT BLOG TITLED "FASTING AND CARDIO-PROTECTION")
DRY FASTING: THE ULTIMATE PATH TO LONGEVITY —A TRUE LIFE OR DEATH SCENARIO On extended dry fasts the first few days are the roughest as the body is still optimistically holding out for food or water but once it figures out that water and food are not coming and that death is imminent if it doesn't adapt and fast to given circumstance it switches gears into survival mode— this highly adapted state IS the magical key of dry fasting. Survival of the fittest. All weakness is eradicated. The option of supporting the diseased and parasitic is no longer viable. All non essentials are eliminated and recycled to sustain the essentials. This IS cellular renewal at the deepest level— unattainable by any other means. A 5 DAY DRY FAST SCIENTIFIC STUDY: "Background: Although there is considerable research in the field of fasting and fluid restriction, little is known about the impact of food and water deprivation (FWD) on body circumferences and vital parameters. Methods: During 5 days of FWD in 10 healthy adults, hemodynamic, metabolic, and renal parameters, such as weight, 5 circumferences at neck, waist, hip, chest at axilla, chest at nipples, and 1 new oblique hip circumference were measured daily. For each circumference, new quotients of daily circumference-to-weight decrease were calculated. The set of employed parameters quantified and monitored dieting persons' compliance and efficacy of the method. Results: The values of blood pressure, heart rate, hemoglobin oxygen saturation, glucose, K+, Na+, Cl-, urea, creatinine, and serum osmolality proved to be stable. The mean creatinine clearance increased up to 167%. The mean daily weight decrease (1,390 ± 60 g) demonstrated the effectiveness of FWD in weight reduction. The daily decrease of all measured circumferences and the values of the corresponding circumference-to-weight decrease quotients reflected considerable volume decrease in all measured body parts per day and kg of weight loss during FWD. Conclusion: The intervention of 5 FWD days in 10 healthy adults was found to be safe, decreased weight and all measured circumferences, and improved renal function considerably." http://www.karger.com/Article/Abstract/357718 While indeed longer duration dry fasts, 3 to 7 days and beyond, are best utilized to bring an ill or obese person back into balance—once homeostasis is restored daily dry (or zero calorie fluid restricted) fasting is the most effective disease preventive measure one can employ in maintaining optimal health and delaying aging. IMPORTANT: The exact reason why fluid is TEMPORARILY restricted will be explained in depth below; ***the goal is NOT chronic dehydration***as that would obviously have negative consequences; downregulation of Klotho being one. WHAT IS KLOTHO? Klotho, a transmembrane protein, protease, and hormone mainly expressed in renal tissue counteracts aging. Overexpression of Klotho substantially prolongs the life span. Klotho deficiency leads to excessive formation of 1,25(OH)2D3, growth deficit, accelerated aging, and early death. Aging is frequently paralleled by dehydration, which is considered to accelerate the development of age-related disorders. The present study explored the possibility that dehydration influences Klotho expression. Klotho transcript levels were determined by