GYPENOSIDE
September 24, 2022EXTRACELLULAR MICROVESICLES
September 24, 2022- Metabolic messengers: FGF21
- Advances in biological functions and clinical studies of FGF21
- FGF21 in obesity and cancer: New insights
- A pyrexic effect of FGF21 independent of energy expenditure and UCP1
- FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes
- FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit
- Stress-induced FGF21 and GDF15 in obesity and obesity resistance
- FGF19 and FGF21: In NASH we trust
- The roles and pharmacological effects of FGF21 in preventing aging-associated metabolic diseases
- Hepatic hormone FGF21 and its analogues in clinical trials
- Gut microbiota mediate the FGF21 adaptive stress response to chronic dietary protein-restriction in mice
- Association between serum FGF21 level and sarcopenia in older adults
- FGF21 facilitates autophagy in prostate cancer cells by inhibiting the PI3K–Akt–mTOR signaling pathway
- Neuroprotective effects of the FGF21 analogue LY2405319
- Hepatic FGF21 preserves thermoregulation and cardiovascular function during bacterial inflammation
- A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21
- FGF21 is required for protein restriction to extend lifespan and improve metabolic health in male mice
- Pharmacological treatment with FGF21 strongly improves plasma cholesterol metabolism to reduce atherosclerosis
- Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21
- The Nuanced Metabolic Functions of Endogenous FGF21 Depend on the Nature of the Stimulus, Tissue Source, and Experimental Model
- OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21
- Diagnostic value of serum biomarkers FGF21 and GDF15 compared to muscle sample in mitochondrial disease
- Hepatic P38 activation modulates systemic metabolism through FGF21-mediated interorgan communication
- FGF21 promotes non-small cell lung cancer progression by SIRT1/PI3K/AKT signaling
- Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and-independent mechanisms
- Central FGF21 production regulates memory but not peripheral metabolism
- Differential roles of GDF15 and FGF21 in systemic metabolic adaptation to the mitochondrial integrated stress response
- FGF21 prevents low-protein diet-induced renal inflammation in aged mice
- The same metabolic response to FGF21 administration in male and female obese mice is accompanied by sex-specific changes in adipose tissue gene expression
- Higher fasting plasma FGF21 concentration is associated with lower ad libitum soda consumption in humans
- Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer’s disease in comparison with healthy aging
- FGF21 is required for the metabolic benefits of IKKε/TBK1 inhibition
- Hepatic CPT1A Facilitates Liver–Adipose Cross Talk via Induction of FGF21 in Mice
- LLF580, an FGF21 analog, reduces triglycerides and hepatic fat in obese adults with modest hypertriglyceridemia
- FGF21 (Fibroblast Growth Factor 21) defines a potential cardiohepatic signaling circuit in end-stage heart failure
- FGF21 serum levels are related to insulin resistance, metabolic changes and obesity in Mexican people living with HIV (PLWH)
- FGF21 promotes migration and differentiation of epidermal cells during wound healing via SIRT1‐dependent autophagy
- Relationship between FGF21 and drug or nondrug therapy of type 2 diabetes mellitus
- Integration of FGF21 signaling and metabolomics in high-fat diet-induced obesity
- FGF21 induced by the ASK1-p38 pathway promotes mechanical cell competition by attracting cells
- FGF21/adiponectin ratio predicts deterioration in glycemia: a 4.6-year prospective study in China
- FGF21 ameliorates hepatic fibrosis by multiple mechanisms
- Ultrasound-assisted C3F8-filled PLGA nanobubbles for enhanced FGF21 delivery and improved prophylactic treatment of diabetic cardiomyopathy
- Anterograde regulation of mitochondrial genes and FGF21 signaling by hepatic LSD1
- Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure
- Dynamic folding modulation generates FGF21 variant against diabetes
- Serum FGF21 levels are altered by various factors including lifestyle behaviors in male subjects
- FoxO1 suppresses FGF21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance
- FGF21 modulates mitochondrial stress response in cardiomyocytes only under mild mitochondrial dysfunction
- Association of plasma FGF21 levels with muscle mass and muscle strength in a national multicentre cohort study: Korean Frailty and Aging Cohort Study
- Bupleuri radix extract ameliorates impaired lipid metabolism in high-fat diet-induced obese mice via gut microbia-mediated regulation of FGF21 signaling …
- FGF21: A novel regulator of glucose and lipid metabolism and whole-body energy balance
- Pubertal FGF21 deficit is central in the metabolic pathophysiology of an ovine model of polycystic ovary syndrome
- Severe protein deficiency induces hepatic expression and systemic level of FGF21 but inhibits its hypothalamic expression in growing rats
- Short‐term protein restriction at advanced age stimulates FGF21 signalling, energy expenditure and browning of white adipose tissue
- Sulforaphane Regulates Glucose and Lipid Metabolisms in Obese Mice by Restraining JNK and Activating Insulin and FGF21 Signal Pathways
- Phytochemicals from the cocoa shell modulate mitochondrial function, lipid and glucose metabolism in hepatocytes via activation of FGF21/ERK, AKT, and mTOR …
- Sulforaphane ameliorates non-alcoholic fatty liver disease in mice by promoting FGF21/FGFR1 signaling pathway
- Serum levels of FGF21, β-klotho, and BDNF in stable coronary artery disease patients with depressive symptoms: a cross-sectional single-center study
- Retinal glial remodeling by FGF21 preserves retinal function during photoreceptor degeneration
- Dietary Patterns and Their Associations With the FTO and FGF21 Gene Variants Among Emirati Adults
- Alginate self-adhesive hydrogel combined with dental pulp stem cells and FGF21 repairs hemisection spinal cord injury via apoptosis and autophagy …
- Mice with high FGF21 serum levels had a reduced preference for morphine and an attenuated development of acute antinociceptive tolerance and physical …
- Leptin, Acting at Central Level, Increases FGF21 Expression in White Adipose Tissue via PPARβ/δ
- FGF21 promotes ischaemic angiogenesis and endothelial progenitor cells function under diabetic conditions in an AMPK/NAD+‐dependent manner
- Ketone body and FGF21 coordinately regulate fasting-induced oxidative stress response in the heart
- FOXO1 inhibition synergizes with FGF21 to normalize glucose control in diabetic mice
- Preparation, characterization, and pharmacological study of a novel long-acting FGF21 with a potential therapeutic effect in obesity
- Ahnak deficiency attenuates high-fat diet-induced fatty liver in mice through FGF21 induction
- Plasma from healthy donors protects blood–brain barrier integrity via FGF21 and improves the recovery in a mouse model of cerebral ischaemia
- FGF21 attenuates high uric acid‑induced endoplasmic reticulum stress, inflammation and vascular endothelial cell dysfunction by activating Sirt1
- P7C3‐A20 alleviates fatty liver by shaping gut microbiota and inducing FGF21/FGF1, via the AMP‐activated protein kinase/CREB regulated transcription coactivator 2 …
- The miR-182-5p/FGF21/acetylcholine axis mediates the crosstalk between adipocytes and macrophages to promote beige fat thermogenesis
- Levels of β-klotho determine the thermogenic responsiveness of adipose tissues: Involvement of the autocrine action of FGF21
- Neural afferents as potential targets to ameliorate FGF21-mediated sympathoexcitation
- The role of FGF21 in the pathogenesis of cardiovascular disease
- Fibroblast growth factor 21 (FGF21) alleviates senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the SIRT1-mTOR signaling …
- Pharmacological FGF21 signals to glutamatergic neurons to enhance leptin action and lower body weight during obesity
- Long-term adjustment of hepatic lipid metabolism after chronic stress and the role of FGF21
- MiR-26b-5p regulates the preadipocyte differentiation by targeting FGF21 in goats
- Does FGF21 Mediate the Potential Decrease in Sweet Food Intake and Preference Following Bariatric Surgery?
- FGF21 enhances therapeutic efficacy and reduces side effects of dexamethasone in treatment of rheumatoid arthritis
- FGF21 Serum Levels in the Early Second Trimester Are Positively Correlated With the Risk of Subsequent Gestational Diabetes Mellitus: A Propensity …
- Behavioral, Hormonal, Inflammatory, and Metabolic Effects Associated with FGF21-Pathway Activation in an ALS Mouse Model
- FGF21: a promising therapeutic agent for alcoholic cardiomyopathy?†
- Evaluation of testicular glycogen storage, FGF21 and LDH expression and physiological parameters of sperm in hyperglycemic rats treated with …
- The relationship between sarcopenia detected in newly diagnosed colorectal cancer patients and FGF21, irisin and CRP levels
- FGF21 attenuates hypoxia‑induced dysfunction and inflammation in HPAECs via the microRNA‑27b‑mediated PPARγ pathway
- Pegbelfermin, a PEGylated FGF21 analogue, has pharmacology without bone toxicity after 1-year dosing in skeletally-mature monkeys
- FGF21 controls hepatic lipid metabolism via sex-dependent interorgan crosstalk
- Suppressive Effect of Autocrine FGF21 on Autophagy-Deficient Hepatic Tumorigenesis
- Novel adipokines CTRP1, CTRP9, and FGF21 in pediatric type 1 and type 2 diabetes: a cross-sectional analysis
- A novel GLP-1 and FGF21 dual agonist has therapeutic potential for diabetes and non-alcoholic steatohepatitis
- FGF21 impedes peripheral myelin development by stimulating p38 MAPK/c‐Jun axis
- Bicistronic reporter mice for monitoring of FGF21 expression
- Nutritional Regulation of Hepatic FGF21 by Dietary Restriction of Methionine
- FGF21 response to sucrose is associated with BMI and dorsal striatal signaling in humans
- Impact of Acutely Increased Endogenous-and Exogenous Ketone Bodies on FGF21 Levels in Humans
- FGF21-FGFR4 signaling in cardiac myocytes promotes concentric cardiac hypertrophy in mouse models of diabetes
- Mesenchymal stem cells modified by FGF21 and GLP1 ameliorate lipid metabolism while reducing blood glucose in type 2 diabetic mice
- Protein-carbohydrate interaction effects on energy balance, FGF21, IGF-1, and hypothalamic gene expression in rats
- Dietary induction of obesity and insulin resistance is associated with changes in FGF21 DNA methylation in liver of mice
- Hepatic Hedgehog Signaling Participates in the Crosstalk between Liver and Adipose Tissue in Mice by Regulating FGF21
- Combined genetic deletion of GDF15 and FGF21 has modest effects on body weight, hepatic steatosis and insulin resistance in high fat fed mice
- Brite Adipocyte FGF21 Attenuates Cardiac Ischemia/Reperfusion Injury in Rat Hearts by Modulating NRF2
- Subcutaneous delivery of FGF21 mRNA therapy reverses obesity, insulin resistance, and hepatic steatosis in diet-induced obese mice
- Deficiency of Cathelicidin Attenuates High-Fat Diet Plus Alcohol-Induced Liver Injury through FGF21/Adiponectin Regulation
- Lycopene attenuates oxidative stress-induced hepatic dysfunction of insulin signal transduction: involvement of FGF21 and mitochondria
- Plasma Tsukushi Concentration Is Associated with High Levels of Insulin and FGF21 and Low Level of Total Cholesterol in a General Population without Medication
- Therapeutic effect and mechanism of combined use of FGF21 and insulin on diabetic nephropathy
- FGF21 alleviates acute liver injury by inducing the SIRT1‐autophagy signalling pathway
- Association of Elevated Plasma FGF21 and Activated FGF21 Signaling in Visceral White Adipose Tissue and Improved Insulin Sensitivity in Gestational …
- Effects of feeding frequency on growth performance, feed intake, metabolism and expression of FGF21 in grass carp (Ctenopharyngodon idellus)
- FGF21 outperforms GDF15 as a diagnostic biomarker of mitochondrial disease in children
- Plasma FGF21 concentrations and spontaneous self-selection of protein suggest that 15% protein in the diet may not be enough for male adult rats
- Acute deletion of the FOXO1-dependent hepatokine FGF21 does not alter basal glucose homeostasis or lipolysis in mice
- The Roles of FGF21 and ALCAT1 in Aerobic Exercise-Induced Cardioprotection of Postmyocardial Infarction Mice
- Rats self-select a constant protein-to-carbohydrate ratio rather than a constant protein-to-energy ratio and have low plasma FGF21 concentrations
- FGF21 alleviates pulmonary hypertension by inhibiting mTORC1/EIF4EBP1 pathway via H19
- Genome-wide association study for circulating FGF21 in patients with alcohol use disorder: Molecular links between the SNHG16 locus and catecholamine …
- Sitagliptin reduces FAP-activity and increases intact FGF21 levels in patients with newly detected glucose abnormalities
- FGF21 regulates alcohol intake: New hopes on the rise for alcohol use disorder treatment?
- Changes in hepatic triglyceride content with the activation of ER stress and increased FGF21 secretion during pregnancy
- Combined Therapy with a CCR2/CCR5 Antagonist and FGF21 Analogue Synergizes in Ameliorating Steatohepatitis and Fibrosis
- Recombinant FGF21 Attenuates Polychlorinated Biphenyl-Induced NAFLD/NASH by Modulating Hepatic Lipocalin-2 Expression
- ZFP36L1 regulates FGF21 mRNA turnover and modulates alcoholic hepatic steatosis and inflammation in mice
- Neuroprotective Effect of Lentivirus-Mediated FGF21 Gene Delivery in Experimental Alzheimer’s Disease is Augmented when Concerted with Rapamycin
- Efruxifermin, a long‐acting Fc‐fusion FGF21 analogue, reduces body weight gain but does not increase sympathetic tone or urine volume in Sprague Dawley rats
- Aerobic exercise regulates FGF21 and NLRP3 inflammasome-mediated pyroptosis and inhibits atherosclerosis in mice
- Another Kid on the Block: Long-acting FGF21 Analogue to Treat Dyslipidemia and Fatty Liver
- Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis
- FGF21 normalizes plasma glucose in mouse models of type 1 diabetes and insulin receptor dysfunction
- FGF21 attenuates pulmonary arterial hypertension via downregulation of miR‐130, which targets PPARγ
- Liraglutide regulates lipid metabolism via FGF21-LKB1-AMPK-ACC1 pathway in white adipose tissues and macrophage of type 2 diabetic mice
- Single Nucleotide Polymorphisms in Close Proximity to the Fibroblast Growth Factor 21 (FGF21) Gene Found to Be Associated with Sugar Intake in a Swedish …
- Pyruvate Upregulates Hepatic FGF21 Expression by Activating PDE and Inhibiting cAMP–Epac–CREB Signaling Pathway
- Plasma FGF21 concentrations are regulated by glucose independently of insulin and GLP-1 in lean, healthy humans
- Associations of FGF21 and GDF15 with mitochondrial dysfunction in children living with perinatally-acquired HIV: A cross-sectional evaluation of pediatric …
- The effect of FGF21 and its genetic variants on food and drug cravings, adipokines and metabolic traits
- Dynamic effects of dietary protein restriction on body weights, food consumption, and protein preference in C57BL/6J and FGF21‐KO mice
- Association between FGF19, FGF21 and lipocalin-2, and diabetes progression in PCOS
- Attenuation of FGF21 signalling might aggravate the impairment of glucose homeostasis during the high sucrose diet induced transition from prediabetes to …
- Hepatocyte-Secreted Autotaxin Exacerbates Nonalcoholic Fatty Liver Disease Through Autocrine Inhibition of the PPARα/FGF21 Axis
- An FGF21-like gene from swamp eel (Monopterus albus): Recombinant expression and its potential roles in glucose and lipid homeostasis
- … SIRT1 to regulate cell apoptosis, inflammatory response, and oxidative stress in acute myocardial infarction in rats via modulation of the FGF21/CREB/PGC1α pathway
- FGF21 and chronic kidney disease
- Potential of Hibiscus sabdariffa Linn. in managing FGF21 resistance in diet‐induced‐obesity rats via miR‐34a regulation
- High baseline FGF21 levels are associated with poor glucose-lowering efficacy of exenatide in patients with type 2 diabetes
- Dimethyl itaconate attenuates palmitate-induced insulin resistance in skeletal muscle cells through the AMPK/FGF21/PPARδ-mediated suppression of inflammation
- FGF21 Reduces Lipid Accumulation in Bovine Hepatocytes by Enhancing Lipid Oxidation and Reducing Lipogenesis via AMPK Signaling
- TWIST2 inhibits EMT and induces oxidative stress in lung cancer cells by regulating the FGF21-mediated AMPK/mTOR pathway
- Elevated serum FGF21 predicts the major adverse cardiovascular events in STEMI patients after emergency percutaneous coronary intervention
- DPP-4 inhibitor induces FGF21 expression via sirtuin 1 signaling and improves myocardial energy metabolism
- Non-Alcoholic Steatohepatitis Severity Associates with FGF21 Level and Kidney Glucose Uptake
- … -Cas9-based genome-wide screening identified novel targets for treating sorafenib-resistant hepatocellular carcinoma: a cross-talk between FGF21 and the NRF2 …
- Fatty Acid Desaturase 1 Influences Hepatic Lipid Homeostasis by Modulating the PPARα‐FGF21 Axis
- SNAI1 is upregulated during muscle regeneration and represses FGF21 and ATF3 expression by directly binding their promoters
- Production of active human FGF21 using tobacco mosaic virus-based transient expression system
- Circulating FGF21 vs. Stress Markers in Girls during Childhood and Adolescence, and in Their Caregivers: Intriguing Inter-Relations between Overweight/Obesity …
- Increased fibroblast growth factor 21 (FGF21) concentration in early second trimester amniotic fluid and its association with fetal growth
- Epigallocatechin-3-gallate ameliorates hepatic damages by relieve FGF21 resistance and promotion of FGF21–AMPK pathway in mice fed a high fat diet
- Dietary Essential Amino Acid Restriction Promotes Hyperdipsia via Hepatic FGF21
- Refined-JinQi-JiangTang tablet ameliorates hypertension through activation of FGF21/FGFR1 axis in fructose-fed rats
- Non-Alcoholic Fatty Liver Disease in Long-Term Type 2 Diabetes: Role of rs738409 PNPLA3 and rs499765 FGF21 Polymorphisms and Serum Biomarkers
- Fibroblast Growth Factor 21 (FGF21) Administration Sex-Specifically Affects Blood Insulin Levels and Liver Steatosis in Obese Ay Mice
- FGF21 contributes to metabolic improvements elicited by combination therapy with exenatide and pioglitazone in patients with type 2 diabetes
- Visceral adipose tissue-directed FGF21 gene therapy improves metabolic and immune health in BTBR mice
- Alternate-day fasting alleviates high fat diet induced non-alcoholic fatty liver disease through controlling PPARα/FGF21 signaling
- Serum levels of the cold stress hormones FGF21 and GDF-15 after cardiac arrest in infants and children enrolled in single center therapeutic hypothermia clinical trials
- Alcoholic fatty liver is blunted by rFGF21 administration in mice lacking adipose FGFR1: The role of FGF21 in PPARα-mediated regulation of adipose tissue mass
- The role of increased FGF21 in VLDL-TAG secretion and thermogenic gene expression in mice under protein malnutrition
- Sustained reduction of triglyceride and LDL cholesterol from single administration of the novel long-acting FGF21 analogue 0499
- FGF21 alleviates chronic inflammatory injury in the aging process through modulating polarization of macrophages
- KLF4 downregulates FGF21 to activate inflammatory injury and oxidative stress of LPS‑induced ATDC5 cells via SIRT1/NF‑κB/p53 signaling
- Does an increase in serum FGF21 level predict 28-day mortality of critical patients with sepsis and ARDS?
- Changes and significance of serum FGF21 in children with primary nephrotic syndrome and chronic renal failure
- Reduced triglycerides and LDL cholesterol from once-weekly administration of the well-tolerated novel FGF21 analogue 0499
- The Regulation Mechanism of different hair types in Inner Mongolia Cashmere Goat based on PI3K-AKT Pathway and FGF21
- Estradiol-dependent and independent effects of FGF21 in obese female mice
- Fibroblast growth factor 21 (FGF21) is increased in MDD and interacts with body mass index (BMI) to affect depression trajectory
- β-Hydroxybutyrate upregulates FGF21 expression through inhibition of histone deacetylases in hepatocytes
- FGF21 promotes wound healing of rat brain microvascular endothelial cells through facilitating TNF-α-mediated VEGFA and ERK1/2 signaling pathway
- FGF21 has a sex-specific role in calorie-restriction-induced beiging of white adipose tissue in mice
- FGF21 improves LPS-induced pulmonary microvascular endothelial cell dysfunction and inflammatory response through SIRT1-mediated NF-κB deacetylation
- Autotaxin, PPARs, and FGF21: An Eye Opener for Progressive Liver Disease?
- Author Correction: Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice
- FGF21 Counteracts Alcohol Intoxication by Activating Noradrenergic Neurons
- hsa_circ_0001955 Promotes Colorectal Cancer Progression by Regulating miR-583/FGF21 Axis
- Src homology 3 domain binding kinase 1 protects against hepatic steatosis and insulin resistance through the Nur77–FGF21 pathway
- Relationship between Serum FGF21 and vWF Expression and Carotid Atherosclerosis in Elderly Patients with Hypertension
- FGF21 defines a potential cardio-hepatic signaling circuit in human heart failure
- GATA2/FGF21 Axis Regulates the Effects of High Glucose on the Apoptosis, Autophagy and Oxidative Stress of Human Umbilical Vein Endothelial Cell via PI3K/AKT …
- Autocrine FGF21 signalling promotes beiging
- Elabela prevents angiotensin II-induced apoptosis and inflammation in rat aortic adventitial fibroblasts via the activation of FGF21–ACE2 signaling
- Circulating myokines IL-6, IL-15 and FGF21 response to training is altered by exercise type but not by menopause in women with obesity
- Cardiovascular autonomic reflex tests and serum FGF21 levels in overweight and normal-weight men and women
- Protein preference and elevated plasma FGF21 induced by dietary protein restriction is similar in both male and female mice
- Involvement of FGF21 in pulmonary fibrosis
- Serum FGF21 levels are altered with various factors including lifestyle behaviors
- How a metabolic hormone, FGF21 (fibroblast growth factor 21) impacts reproduction
- FGF21 Response Varies by Sugar Type and is Associated with Body Weight, Dietary Added Sugar, and Neural Signaling in Humans
- Increased Plasma FGF21 and Activated FGF21 Signaling in Adipose Tissue and Its Possible Association With Insulin Sensitivity in Specific GDM Subtype
- Brite Adipocyte FGF21 Attenuates Cardiac Ischemia/Reperfusion Injury in Rat Hearts by Modulating NRF2. Cells 2022, 11, 567
- Early warning for inactive ovaries based on liver function index, serum MDA, IL-6, FGF21 and ANGPTL8 in dairy cows
- Fibroblast growth factor 21 (FGF21) is a sensitive marker of osteoporosis in haemodialysis patients: a cross-sectional observational study
- Activating Effects of the Bioactive Compounds From Coffee By-Products on FGF21 Signaling Modulate Hepatic Mitochondrial Bioenergetics and Energy …
- Effect of aquatic training on serum Fetuin-A, ANGPTL4 and FGF21 levels in type 2 diabetic obese women
- Effect of Exercise Training on Serum FGF21 Level in Adults with Metabolic Disorders, A Meta-Analysis
- … -Transcriptome Sequencing Reveals CeRNA Regulatory Network of mRNAs, lncRNAs, miRNAs and circRNAs in Pulmonary Hypertension Treated with FGF21
- FGF21 Is a Potential Therapeutic for Morphine Preference and Dependence
- Correlation between Serum FGF21 Level and Diabetic Peripheral Neuropathy
- 115-LB: Liver-Derived FGF21 Mediates the Promoting Effect of Glucagon Receptor Antagonism on Beta-Cell Regeneration in Type 2 Diabetic Mice
- FGF21 Promotes Proliferation and Estradiol Synthesis in Porcine Granulosa Cells
- Virtual Reality Alleviates Post-Stroke Depression by Regulating FGF21
- Homocysteine-induced endoplasmic reticulum stress activates FGF21 via CREBH, resulting in browning and atrophy of white adipose tissue in Bhmt knockout mice
- Endogenous GDF15 and FGF21 additively alleviate hepatic steatosis and insulin resistance in obese mice.
- Population Pharmacokinetics (PK) and Pharmacodynamics (PD) of BIO89-100, a Novel GlycoPEGylated FGF21, in a Phase 1b/2a POC Study in Nonalcoholic …
- Obesity-resistance of UCP1-deficient mice associates with sustained FGF21 sensitivity in inguinal adipose tissue
- … 21 (FGF21) is increased in individuals with gestational diabetes mellitus (GDM) after 24 gestational weeks. However, it is unknown whether the increase in FGF21 …
- Pharmacokinetics of FGF21-164 fusion protein in mice using UHPLC-MS/MS method
- Effects of different exercise on liver lipid accumulation and FGF21 secretion in obese rats
- Association of Common Variants of FGF21 Gene Polymorphism Rs499765 and Rs838133 with Type 2 Diabetes Mellitus in Iraqi Population
- The effect of high Intensity Interval Training (HIIT) on adipsin, FGF21 and ABCA1 indices in obese men
- Design and characterization of a FGF1-FGF21 chimeric protein with increased stability and enhanced antidiabetic activities.
- Erratum. Hepatic CPT1A Facilitates Liver-Adipose Cross Talk via Induction of FGF21 in Mice. Diabetes 2022; 71: 31-42
- 144-OR: Adipose Modeling of FGF21 Signaling Mutations in a Severe Insulin Resistance Syndrome
- MiR-26b-5p Promotes Osteogenesis of Bone Mesenchymal Stem Cells via Suppressing FGF21
- The effect of special training exercise on FGF21 expression and FGFR-1 among CABG patients
- Multi-year participation in prolonged athletic training is associated with higher risk of chronic fatigue and abnormal serum FGF21 levels in professional athletes
- LLF580, an FGF21 Analog, Reduces Triglycerides and Hepatic Fat in obese persons with modestly elevated triglycerides: A 12 Week Randomized Double Blind …
- Abstract TP235: Delayed FGF21 Administration Improves Cerebrovascular Remodeling And White Matter Repair After Focal Stroke In Diabetic Mice
- FGF21 restores hippocampual mitochondrial dysfunction via enhancing Nrf2/HO-1 and AMPK/SirT1/PGC-1α signaling pathways to alleviate chronic …
- … Select Abstract: The Beneficial Effect of Fenofibrate on Diabetic Retinopathy Is Influenced by PPARA Genetic Variability and Is Mediated by an Increase in FGF21 …
- Effect of Eight Weeks of Aerobic Exercise with Ginger Supplementation on FGF21, Irisin and Insulin Resistance in Women with Type 2 Diabetes
- The Hepatokine FGF21 Increases the Human Spermatozoa Motility
- Homocysteine-induced endoplasmic reticulum stress activates FGF21 via CREBH, resulting in browning and atrophy of white adipose tissue in Bhmt knockout mice
- FGF21 Levels and Bone Mineral Density in Metabolically Healthy and Metabolically Unhealthy Obese Children
- The association between FGF21 and diabetic erectile dysfunction: Evidence from clinical and animal studies
- FGF21 is released during increased lipogenesisis state following rapid-onset radioiodine-induced hypothyroidism
- 1379-P: Combination of FGF21 and ß3-Adrenergic Treatment in Obese Mice
- FGF21 Promotes Senescence, Apoptosis, and Extracellular Matrix Degradation in Osteoarthritis via the AMPK Signaling Pathway
- 286-OR: FGF21 Decreases Hepatic Triglycerides in a Weight Loss-Independent but Sex-Dependent Manner
- Close association between lifestyle and circulating FGF21 levels: A systematic review and meta-analysis
- FGF21/FGFR1-β-KL Cascade in Cardiomyocytes Modulates Angiogenesis and Inflammation Under Metabolic Stress
- FGF21 Normalizes Plasma Glucose in Mouse Models of Type 1 Diabetes and Insulin Receptor Dysfunction John L Diener1, 2, Sarah Mowbray1, Waan-Jeng …
- Serum FGF21 Levels Predict the MACE in Patients With Myocardial Infarction After Coronary Artery Bypass Graft Surgery
- Multi-organ FGF21-FGFR1 signaling in metabolic health and disease
- Corrigendum to” Dietary protein dilution limits dyslipidemia in obesity through FGF21-driven fatty acid clearance”[The Journal of Nutritional Biochemistry 57 (2018) …
- Circulating FGF21 and GDF15 as Biomarkers for Screening, Diagnosis, and Severity Assessment of Primary Mitochondrial Disorders in Children
- (+)-Dehydrovomifoliol Alleviates Oleic Acid-Induced Lipid Accumulation in HepG2 Cells via the PPARα–FGF21 Pathway
- The effect of 8 weeks of high-intensity interval training (HIIT) Tribulus terrestris supplementation on serum BDNF and FGF21 in obese women
- 212-LB: Therapeutic Effect of a Novel Long-Acting GLP-1/GCG/FGF21/Anticytokine Tetra-Specific Liver Microenvironment-Targeting Drug (OGB21502) in MCD …
- Maternal High-Fat Diet Alters the Characteristics of Astrocytes and Worsens the Outcome of Stroke in Rat Offspring, Which Improves After FGF21 …
- 211-LB: Antifibrotic Effect of a Novel Long-Acting GLP-1/GCG/FGF21/Anti-Cytokine Tetra-Specific Liver Microenvironment-Targeting Drug (OGB21502) in CCl4 …
- FGF21 contributes to metabolic improvements elicited by combination therapy with exenatide and pioglitazone in patients with type 2 diabetes
- Hepatic Stearoyl-CoA desaturase deficiency-mediated induction of the insulin-like growth factor-binding protein 1 requires FGF21.
- Examining the potential of Urolithins to induce hepatic Fibroblast Growth Factor 21 (FGF21) Expression and Release in High Fat Diet Induced Obesity
- 208-LB: Peripheral CB1 Inverse Agonism Improves Metabolism in DIO Mice Independent of Hepatic FGF21
- Understanding the physiology of FGF21
- Inventing new medicines: the FGF21 story
- The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic
- FGF21 is an Akt-regulated myokine
- FGF21 Requires βklotho to Act In Vivo
- FGF21 and cardiac physiopathology
- Going back to the biology of FGF21: new insights
- The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes
- PPARα is a key regulator of hepatic FGF21
- Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans
- FGF21 reloaded: challenges of a rapidly growing field
- FGF21 as a stress hormone: the roles of FGF21 in stress adaptation and the treatment of metabolic diseases
- A dozen years of discovery: insights into the physiology and pharmacology of FGF21
- FGF21 as a hepatokine, adipokine, and myokine in metabolism and diseases
- Different roles of N‐and C‐termini in the functional activity of FGF21
- FGF21 is an endocrine signal of protein restriction
- Discrete aspects of FGF21 in vivo pharmacology do not require UCP1
- A new frontier in FGF21 biology
- FGF21-based pharmacotherapy–potential utility for metabolic disorders
- FGF21: a novel prospect for the treatment of metabolic diseases
- FGF21 regulates sweet and alcohol preference
- FGF21 revolutions: recent advances illuminating FGF21 biology and medicinal properties
- Thermogenic activation induces FGF21 expression and release in brown adipose tissue
- FGF21 as Modulator of Metabolism in Health and Disease
- Interplay between FGF21 and insulin action in the liver regulates metabolism
- Defining the nutritional and metabolic context of FGF21 using the geometric framework
- Paradoxical regulation of human FGF21 by both fasting and feeding signals: is FGF21 a nutritional adaptation factor?
- FGF21 and the late adaptive response to starvation in humans
- FGF21 regulates metabolism through adipose-dependent and-independent mechanisms
- Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice
- FGF21 N-and C-termini play different roles in receptor interaction and activation
- FGF21: a missing link in the biology of fasting
- Increased serum FGF21 levels in patients with nonalcoholic fatty liver disease
- Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress
- Physiological and pharmacological roles of FGF21 in cardiovascular diseases
- The fasting polypeptide FGF21 can enter brain from blood
- FGF21 and the physiological regulation of macronutrient preference
- TNF-α represses β-Klotho expression and impairs FGF21 action in adipose cells: involvement of JNK1 in the FGF21 pathway
- Long-term cold adaptation does not require FGF21 or UCP1
- Inhibition of growth hormone signaling by the fasting-induced hormone FGF21
- FGF21 regulates metabolism and circadian behavior by acting on the nervous system
- Acute exercise induces FGF21 expression in mice and in healthy humans
- Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice
- Novel locus including FGF21 is associated with dietary macronutrient intake
- Lack of overt FGF21 resistance in two mouse models of obesity and insulin resistance
- Autophagy deficiency leads to protection from obesity and insulin resistance by inducing FGF21 as a mitokine
- Serum levels of the adipokine FGF21 depend on renal function
- Pharmacologic effects of FGF21 are independent of the “browning” of white adipose tissue
- The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARα activation in man
- FGF21 contributes to neuroendocrine control of female reproduction
- Targeting FGF21 for the treatment of nonalcoholic steatohepatitis
- FGF21 is an exocrine pancreas secretagogue
- Understanding the Physical Interactions in the FGF21/FGFR/β‐Klotho Complex: Structural Requirements and Implications in FGF21 Signaling
- Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity
- Fundamentals of FGF19 & FGF21 Action In Vitro and In Vivo
- FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders
- FGF21 is a sugar-induced hormone associated with sweet intake and preference in humans
- FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss
- Brown adipose tissue responds to cold and adrenergic stimulation by induction of FGF21
- Fatty liver and FGF21 physiology
- FGF21 attenuates lipolysis in human adipocytes–a possible link to improved insulin sensitivity
- Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans
- FGF21 gene therapy as treatment for obesity and insulin resistance
- FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
- Serum FGF21 levels are associated with brown adipose tissue activity in humans
- Treating diabetes and obesity with an FGF21-mimetic antibody activating the βKlotho/FGFR1c receptor complex
- FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
- FGF21-receptor agonists: an emerging therapeutic class for obesity-related diseases
- Fructose ingestion acutely stimulates circulating FGF21 levels in humans
- FGF21 mediates the lipid metabolism response to amino acid starvation
- Novel insights into the cardio-protective effects of FGF21 in lean and obese rat hearts
- The roles of FGF21 in atherosclerosis pathogenesis
- LY2405319, an engineered FGF21 variant, improves the metabolic status of diabetic monkeys
- FGF21 mimetic shows therapeutic promise
- Dynamic change of serum FGF21 levels in response to glucose challenge in human
- An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice
- FGF21 takes a fat bite
- FGF21 signals protein status to the brain and adaptively regulates food choice and metabolism
- The regulation of FGF21 gene expression by metabolic factors and nutrients
- Fibroblast growth factors in cardiovascular disease: The emerging role of FGF21
- Rationale-based engineering of a potent long-acting FGF21 analog for the treatment of type 2 diabetes
- Stressed liver and muscle call on adipocytes with FGF21
- FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting
- Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding
- Regulation of longevity by FGF21: Interaction between energy metabolism and stress responses
- Defining “FGF21 Resistance” during obesity: Controversy, criteria and unresolved questions
- Tissue-specific expression of βKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21
- Endocrine protection of ischemic myocardium by FGF21 from the liver and adipose tissue
- FGF21 as an endocrine regulator in lipid metabolism: from molecular evolution to physiology and pathophysiology
- The FGF21–adiponectin axis in controlling energy and vascular homeostasis
- FGF21 promotes metabolic homeostasis via white adipose and leptin in mice
- FGF21 mediates endocrine control of simple sugar intake and sweet taste preference by the liver
- FGF21 as a therapeutic reagent
- Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models—association with liver and adipose tissue effects
- Serum FGF21 levels in adult m. 3243A> G carriers: clinical implications
- Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop
- Circulating FGF21 levels in human health and metabolic disease
- Hepatic FGF21 expression is induced at birth via PPARα in response to milk intake and contributes to thermogenic activation of neonatal brown fat
- Circulating FGF21 proteolytic processing mediated by fibroblast activation protein
- The role of FGF21 in type 1 diabetes and its complications
- A novel approach to improve the function of FGF21
- Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob/ob mice
- Aging is associated with increased FGF21 levels but unaltered FGF21 responsiveness in adipose tissue
- A long-acting FGF21 molecule, PF-05231023, decreases body weight and improves lipid profile in non-human primates and type 2 diabetic subjects
- Plasma FGF21 is elevated by the intense lipid mobilization of lactation
- FGF21 is an insulin-dependent postprandial hormone in adult humans
- SGLT2 inhibition reprograms systemic metabolism via FGF21-dependent and-independent mechanisms
- Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine
- Circulating FGF21 levels are progressively increased from the early to end stages of chronic kidney diseases and are associated with renal function in …
- Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes
- FGF21: an emerging therapeutic target for non-alcoholic steatohepatitis and related metabolic diseases
- Liver derived FGF21 maintains core body temperature during acute cold exposure
- FGF21-mediated improvements in glucose clearance require uncoupling protein 1
- Opposite alterations in FGF21 and FGF19 levels and disturbed expression of the receptor machinery for endocrine FGFs in obese patients
- Research perspectives on the regulation and physiological functions of FGF21 and its association with NAFLD
- Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys
- KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference
- Nrf2 represses FGF21 during long-term high-fat diet–induced obesity in mice
- FGF21: The center of a transcriptional nexus in metabolic regulation
- FGF21 is a hormonal mediator of the human “thrifty” metabolic phenotype
- A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism
- Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice
- FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents
- Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23
- Metabolic responses to dietary protein restriction require an increase in FGF21 that is delayed by the absence of GCN2
- Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21
- Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action
- FGF21 regulates hepatic metabolic pathways to improve steatosis and inflammation
- FGF21 lowers plasma triglycerides by accelerating lipoprotein catabolism in white and brown adipose tissues
- Leptin as a Potential Regulator of FGF21
- Metformin stimulates FGF21 expression in primary hepatocytes
- mTORC1 is a major regulatory node in the FGF21 signaling network in adipocytes
- PGC-1α negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erbα axis
- Effects of insulin and exercise training on FGF21, its receptors and target genes in obesity and type 2 diabetes
- Exercise alleviates obesity-induced metabolic dysfunction via enhancing FGF21 sensitivity in adipose tissues
- Circulating FGF21 in humans is potently induced by short term overfeeding of carbohydrates
- FGF21 signals to glutamatergic neurons in the ventromedial hypothalamus to suppress carbohydrate intake
- Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB
- Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy
- ATF4-and CHOP-dependent induction of FGF21 through endoplasmic reticulum stress
- FGF21 is required for cardiac remodeling in pregnancy
- iNKT cells induce FGF21 for thermogenesis and are required for maximal weight loss in GLP1 therapy
- Dietary methionine restriction reduces inflammation independent of FGF21 action
- FGF21 Is Increased by Inflammatory Stimuli and Protects Leptin-Deficient ob/ob Mice from the Toxicity of Sepsis
- FGF21 as a mediator of adaptive responses to stress and metabolic benefits of anti-diabetic drugs
- FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process
- Metabolic actions of FGF21: molecular mechanisms and therapeutic implications
- FGF21 attenuates pathological myocardial remodeling following myocardial infarction through the adiponectin-dependent mechanism
- FGF21 mediates the thermogenic and insulin-sensitizing effects of dietary methionine restriction but not its effects on hepatic lipid metabolism
- Increased FGF21 plasma levels in humans with sepsis and SIRS
- The PPARα-FGF21 hormone axis contributes to metabolic regulation by the hepatic JNK signaling pathway
- Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice
- A specific ChREBP and PPARα cross-talk is required for the glucose-mediated FGF21 response
- An overview of FGF19 and FGF21: the therapeutic role in the treatment of the metabolic disorders and obesity
- FGF19 and FGF21 for the treatment of NASH—two sides of the same coin? Differential and overlapping effects of FGF19 and FGF21 from mice to human
- Rush to the fire: FGF21 extinguishes metabolic stress, metaflammation and tissue damage
- Impaired mitochondrial fat oxidation induces FGF21 in muscle
- FGF21 increases water intake, urine output and blood pressure in rats
- Obesity is a fibroblast growth factor 21 (FGF21)-resistant state
- Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity
- Plasma FGF21 displays a circadian rhythm during a 72‐h fast in healthy female volunteers
- The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes
- Circadian expression of FGF21 is induced by PPARα activation in the mouse liver
- A long‐acting FGF21 alleviates hepatic steatosis and inflammation in a mouse model of non‐alcoholic steatohepatitis partly through an FGF21‐adiponectin‐IL17A …
- FGF21 attenuates pulmonary fibrogenesis through ameliorating oxidative stress in vivo and in vitro
- Low protein-induced increases in FGF21 drive UCP1-dependent metabolic but not thermoregulatory endpoints
- FGF21 acts as a negative regulator of bile acid synthesis
- FGF21 deficiency is associated with childhood obesity, insulin resistance and hypoadiponectinaemia: the BCAMS Study
- FGF19 subfamily members: FGF19 and FGF21
- Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation
- The FGF21 receptor signaling complex: Klothoβ, FGFR1c, and other regulatory interactions
- FGF21 protects myocardial ischemia-reperfusion injury through reduction of miR-145-mediated autophagy
- The hormone FGF21 stimulates water drinking in response to ketogenic diet and alcohol
- Serum FGF21 levels are increased in newly diagnosed type 2 diabetes with nonalcoholic fatty liver disease and associated with hsCRP levels independently
- High-level expression and purification of soluble recombinant FGF21 protein by SUMO fusion in Escherichia coli
- Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21
- FGF21 mediates mesenchymal stem cell senescence via regulation of mitochondrial dynamics
- Homeostatic sensing of dietary protein restriction: a case for FGF21
- Plasma FGF21 levels are increased in patients with hypothyroidism independently of lipid profile
- FGF21 response to critical illness: effect of blood glucose control and relation with cellular stress and survival
- Development of a novel long-acting antidiabetic FGF21 mimetic by targeted conjugation to a scaffold antibody
- Regulation of FGF21 expression and secretion by retinoic acid receptor-related orphan receptor α
- Hepatic insulin resistance and increased hepatic glucose production in mice lacking FGF21
- FGF21 ameliorates nonalcoholic fatty liver disease by inducing autophagy
- Divergent effects of resistance and endurance exercise on plasma bile acids, FGF19, and FGF21 in humans
- Plasma FGF21 levels in obese patients undergoing energy-restricted diets or bariatric surgery: a marker of metabolic stress?
- Glucagon stimulates hepatic FGF21 secretion through a PKA-and EPAC-dependent posttranscriptional mechanism
- FGF21 is essential for haematopoiesis in zebrafish
- A high circulating FGF21 level as a prognostic marker in patients with acute myocardial infarction
- Polyethylene glycol modified FGF21 engineered to maximize potency and minimize vacuole formation
- Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease
- Peripherally derived FGF21 promotes remyelination in the central nervous system
- An engineered FGF21 variant, LY2405319, can prevent non-alcoholic steatohepatitis by enhancing hepatic mitochondrial function
- FGF21 expression and release in muscle cells: involvement of MyoD and regulation by mitochondria-driven signalling
- Exercise-induced secretion of FGF21 and follistatin are blocked by pancreatic clamp and impaired in type 2 diabetes
- The autocrine role of FGF21 in cultured adipocytes
- Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase
- ANGPTL6 expression is coupled with mitochondrial OXPHOS function to regulate adipose FGF21
- FGF21 resistance is not mediated by downregulation of beta-klotho expression in white adipose tissue
- Liver fat but not other adiposity measures influence circulating FGF21 levels in healthy young adult twins
- parameters, characteristics, and criteria for defining the term “FGF21 resistance”
- FGF21 attenuates high-fat diet-induced cognitive impairment via metabolic regulation and anti-inflammation of obese mice
- FGF19, FGF21, and an FGFR1/β-Klotho-activating antibody act on the nervous system to regulate body weight and glycemia
- FGF21 conducts a metabolic orchestra and fat is a key player
- FGF19 and FGF21 serum concentrations in human obesity and type 2 diabetes behave differently after diet-or surgically-induced weight loss
- Ketogenic diet impairs FGF21 signaling and promotes differential inflammatory responses in the liver and white adipose tissue
- Impact of short-term high-fat feeding and insulin-stimulated FGF21 levels in subjects with low birth weight and controls
- FGF21 improves glucose homeostasis in an obese diabetes-prone mouse model independent of body fat changes
- A liver-bone endocrine relay by IGFBP1 promotes osteoclastogenesis and mediates FGF21-induced bone resorption
- A common allele in FGF21 associated with sugar intake is associated with body shape, lower total body-fat percentage, and higher blood pressure
- Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution
- The FGF21-CCL11 axis mediates beiging of white adipose tissues by coupling sympathetic nervous system to type 2 immunity
- FGF21 prevents angiotensin II-induced hypertension and vascular dysfunction by activation of ACE2/angiotensin-(1–7) axis in mice
- Human HMGCS2 regulates mitochondrial fatty acid oxidation and FGF21 expression in HepG2 cell line
- FGF21 attenuates neurodegeneration through modulating neuroinflammation and oxidant-stress
- Distinct association of serum FGF21 or adiponectin levels with clinical parameters in patients with type 2 diabetes
- Liver-enriched transcription factor CREBH interacts with peroxisome proliferator-activated receptor α to regulate metabolic hormone FGF21
- Loss of FGF21 in diabetic mouse during hepatocellular carcinogenetic transformation
- Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease
- FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway
- FGF21, energy expenditure and weight loss–how much brown fat do you need?
- FGF21 can be mimicked in vitro and in vivo by a novel anti-FGFR1c/β-Klotho bispecific protein
- Epigenetic modulation of FGF21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood
- FGF21 Attenuated LPS-Induced Depressive-Like Behavior via Inhibiting the Inflammatory Pathway
- Impact of FGF21 on glycemic control
- High‐protein diet more effectively reduces hepatic fat than low‐protein diet despite lower autophagy and FGF21 levels
- Dietary betaine supplementation increases FGF21 levels to improve glucose homeostasis and reduce hepatic lipid accumulation in mice
- FGF21 signaling in glutamatergic neurons is required for weight loss associated with dietary protein dilution
- FGF21 administration suppresses retinal and choroidal neovascularization in mice
- Serum FGF21 is associated with future cardiovascular events in patients with coronary artery disease
- Fenofibrate increases cardiac autophagy via FGF21/SIRT1 and prevents fibrosis and inflammation in the hearts of Type 1 diabetic mice
- Glucagon and lipid interactions in the regulation of hepatic AMPK signaling and expression of PPARα and FGF21 transcripts in vivo
- FGF21 alleviates neuroinflammation following ischemic stroke by modulating the temporal and spatial dynamics of microglia/macrophages
- Serum FGF21 levels in obese Korean children and adolescents
- A2A receptor activation attenuates hypertensive cardiac remodeling via promoting brown adipose tissue-derived FGF21
- FGF21 mitigates atherosclerosis via inhibition of NLRP3 inflammasome-mediated vascular endothelial cells pyroptosis
- CREBH improves diet-induced obesity, insulin resistance, and metabolic disturbances by FGF21-dependent and FGF21-independent mechanisms
- FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance
- Inhibition of insulin resistance by PGE1 via autophagy-dependent FGF21 pathway in diabetic nephropathy
- Probiotic culture supernatant improves metabolic function through FGF21-adiponectin pathway in mice
- Up-regulation of Nrf2 is involved in FGF21-mediated fenofibrate protection against type 1 diabetic nephropathy
- FGF21 functions as a sensitive biomarker of APAP-treated patients and mice
- Central resistin/TLR4 impairs adiponectin signaling, contributing to insulin and FGF21 resistance
- Protective effect of FGF21 on type 1 diabetes-induced testicular apoptotic cell death probably via both mitochondrial-and endoplasmic reticulum stress-dependent …
- Serum FGF21 increases with hepatic fat accumulation in pediatric onset intestinal failure
- FGF21 mediates alcohol-induced adipose tissue lipolysis by activation of systemic release of catecholamine in mice [S]
- FGF21 underlies a hormetic response to metabolic stress in methylmalonic acidemia
- Autophagic control of cardiac steatosis through FGF21 in obesity-associated cardiomyopathy
- FGF21, a liver hormone that inhibits alcohol intake in mice, increases in human circulation after acute alcohol ingestion and sustained binge drinking at …
- Lactate induces FGF21 expression in adipocytes through a p38-MAPK pathway
- CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysis
- FGF21 protects dopaminergic neurons in Parkinson’s disease models via repression of Neuroinflammation
- Oncogenic KRAS reduces expression of FGF21 in acinar cells to promote pancreatic tumorigenesis in mice on a high-fat diet
- FGF21 improves cognition by restored synaptic plasticity, dendritic spine density, brain mitochondrial function and cell apoptosis in obese-insulin resistant male rats
- Overexpression of β-klotho in adipose tissue sensitizes male mice to endogenous FGF21 and provides protection from diet-induced obesity
- Skeletal muscle increases FGF21 expression in mitochondrial disorders to compensate for energy metabolic insufficiency by activating the mTOR–YY1–PGC1α …
- Fasting decreases plasma FGF21 in obese subjects and the expression of FGF21 receptors in adipose tissue in both lean and obese subjects
- FGF21 ameliorates the neurocontrol of blood pressure in the high fructose-drinking rats
- FGF21 is not a major mediator for bone homeostasis or metabolic actions of PPARα and PPARγ agonists
- FGF21 protects the blood–brain barrier by upregulating PPARγ via FGFR1/β-klotho after traumatic brain injury
- Mice lacking neutral amino acid transporter B0AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control
- A novel Fc-FGF21 with improved resistance to proteolysis, increased affinity toward β-klotho, and enhanced efficacy in mice and cynomolgus monkeys
- Anti-inflammatory effects of exercise training in adipose tissue do not require FGF21
- Fibroblast growth factor (FGF21) protects mouse liver against D-galactose-induced oxidative stress and apoptosis via activating Nrf2 and PI3K/Akt pathways
- FGF21 and DPP-4 inhibitor equally prevents cognitive decline in obese rats
- Metformin prevents fatty liver and improves balance of white/brown adipose in an obesity mouse model by inducing FGF21
- FGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival
- Hormone resistance in diabetes and obesity: insulin, leptin, and FGF21
- Physiological modulation of circulating FGF21: relevance of free fatty acids and insulin
- FGF21 protects against hypoxia injury through inducing HSP72 in cerebral microvascular endothelial cells
- The hepatokine FGF21 is crucial for peroxisome proliferator-activated receptor-α agonist-induced amelioration of metabolic disorders in obese mice
- FGF21 alleviates hepatic endoplasmic reticulum stress under physiological conditions
- FGF21 and the second coming of PPARγ
- … diet induces, whereas high-protein diet reduces hepatic FGF21 production in mice, but glucose and not amino acids up-regulate FGF21 in cultured hepatocytes
- Hepatic FGF21 mediates sex differences in high-fat high-fructose diet-induced fatty liver
- The nuclear receptor Rev-erbα regulates adipose tissue-specific FGF21 signaling
- Hydrodynamic delivery of FGF21 gene alleviates obesity and fatty liver in mice fed a high-fat diet
- HRD1‐ERAD controls production of the hepatokine FGF21 through CREBH polyubiquitination
- FGF21 induced by carbon monoxide mediates metabolic homeostasis via the PERK/ATF4 pathway
- Lack of FGF21 promotes NASH-HCC transition via hepatocyte-TLR4-IL-17A signaling
- Liver-derived FGF21 is essential for full adaptation to ketogenic diet but does not regulate glucose homeostasis
- Tanycytes regulate lipid homeostasis by sensing free fatty acids and signaling to key hypothalamic neuronal populations via FGF21 secretion
- Activation of cardiac AMPK-FGF21 feed-forward loop in acute myocardial infarction: Role of adrenergic overdrive and lipolysis byproducts
- Association between insulin resistance and impairment of FGF21 signal transduction in skeletal muscles
- Treatment of CIA mice with FGF21 down-regulates TH17-IL-17 axis
- FGF10 and FGF21 as regulators in adipocyte development and metabolism
- FGF21 signalling pathway and metabolic traits–genetic association analysis
- … enzyme-linked immunosorbent assay and ligand-binding mass spectrometry for analysis of biotransformation of protein therapeutics: application to various FGF21 …
- Pharmacokinetics and pharmacodynamics of PF‐05231023, a novel long‐acting FGF21 mimetic, in a first‐in‐human study
- Transcriptional repressor E4-binding protein 4 (E4BP4) regulates metabolic hormone fibroblast growth factor 21 (FGF21) during circadian cycles and feeding
- Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity
- Interactions between FGF21 and BMP-2 in osteogenesis
- FGF21 is not required for glucose homeostasis, ketosis or tumour suppression associated with ketogenic diets in mice
- Time-imposed daily restricted feeding induces rhythmic expression of FGF21 in white adipose tissue of mice
- Dietary protein dilution limits dyslipidemia in obesity through FGF21-driven fatty acid clearance
- Serum FGF21 levels are elevated in association with lipodystrophy, insulin resistance and biomarkers of liver injury in HIV-1-infected patients
- Baseline HOMA IR and circulating FGF21 levels predict NAFLD improvement in patients undergoing a low carbohydrate dietary intervention for weight loss: a …
- Long-term caloric restriction in ApoE-deficient mice results in neuroprotection via FGF21-induced AMPK/mTOR pathway
- Metformin ameliorates experimental-obesity-associated autoimmune arthritis by inducing FGF21 expression and brown adipocyte differentiation
- Hepatic Sel1L‐Hrd1 ER‐associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH
- Pegylated FGF21 rapidly normalizes insulin-stimulated glucose utilization in diet-induced insulin resistant mice
- Diet polyphenol curcumin stimulates hepatic FGF21 production and restores its sensitivity in high-fat-diet–fed male mice
- Long-acting FGF21 inhibits retinal vascular leakage in in vivo and in vitro models
- FGF21 impairs adipocyte insulin sensitivity in mice fed a low-carbohydrate, high-fat ketogenic diet
- Physiology and Endocrinology Symposium: FGF21: Insights into mechanism of action from preclinical studies,
- Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice
- Altered GDF15 and FGF21 levels in response to strenuous exercise: a study in marathon runners
- FGF21 attenuates hypoxia‑induced dysfunction and apoptosis in HPAECs through alleviating endoplasmic reticulum stress
- Selective regulation of FGF19 and FGF21 expression by cellular and nutritional stress
- Hepatic posttranscriptional network comprised of CCR4–NOT deadenylase and FGF21 maintains systemic metabolic homeostasis
- FGF21 mimics a fasting-induced metabolic state and increases appetite in zebrafish
- Relationship between FGF21 and UCP1 levels under time-restricted feeding and high-fat diet
- Molecular Characterization and Mapping of FGF21 Gene in a Foodfish Species Asian Seabass
- Improved FGF21 sensitivity and restored FGF21 signaling pathway in high-fat diet/streptozotocin-induced diabetic rats after duodenal-jejunal bypass and …
- Targeted DNA demethylation of the FGF21 promoter by CRISPR/dCas9-mediated epigenome editing
- Fibroblast growth factor 21 (FGF21) promotes formation of aerobic myofibers via the FGF21‐SIRT1‐AMPK‐PGC1α pathway
- Early increases in serum FGF21 levels predict mortality of septic patients
- Head over hepatocytes for FGF21
- Pharmacokinetics (PK), pharmacodynamics (PD) and integrated PK/PD modeling of a novel long acting FGF21 clinical candidate PF-05231023 in diet …
- Additive protection by LDR and FGF21 treatment against diabetic nephropathy in type 2 diabetes model
- Increased plasma FGF21 level as an early biomarker for insulin resistance and metabolic disturbance in obese insulin-resistant rats
- Elevated FGF21 secretion, PGC-1α and ketogenic enzyme expression are hallmarks of iron–sulfur cluster depletion in human skeletal muscle
- Macronutrient Intake–Associated FGF21 Genotype Modifies Effects of Weight-Loss Diets on 2-Year Changes of Central Adiposity and Body Composition: The …
- Recombinant FGF21 protects against blood-brain barrier leakage through Nrf2 upregulation in type 2 diabetes mice
- FGF21 trafficking in intact human cells revealed by cryo-electron tomography with gold nanoparticles
- Increased serum level of FGF21 in gestational diabetes mellitus
- Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion
- FGF21 suppresses hepatic glucose production through the activation of atypical protein kinase Cι/λ
- FGF21 is induced in cisplatin nephrotoxicity to protect against kidney tubular cell injury
- FGF21 decreases body weight without reducing food intake or bone mineral density in high-fat fed obese rhesus macaque monkeys
- Free fatty acids impair FGF21 action in HepG2 cells
- Low-protein and methionine, high-starch diets increase energy intake and expenditure, increase FGF21, decrease IGF-1, and have little effect on adiposity in mice
- FGF21 mimetic antibody stimulates UCP1-independent brown fat thermogenesis via FGFR1/βKlotho complex in non-adipocytes
- GCN2 and FGF21 are likely mediators of the protection from cancer, autoimmunity, obesity, and diabetes afforded by vegan diets
- A solid-phase PEGylation strategy for protein therapeutics using a potent FGF21 analog
- FAP finds FGF21 easy to digest
- Inhibition of vascular neointima hyperplasia by FGF21 associated with FGFR1/Syk/NLRP3 inflammasome pathway in diabetic mice
- FGF21 represses cerebrovascular aging via improving mitochondrial biogenesis and inhibiting p53 signaling pathway in an AMPK-dependent manner
- FGF21 promotes functional recovery after hypoxic-ischemic brain injury in neonatal rats by activating the PI3K/Akt signaling pathway via FGFR1/β-klotho
- Hepatic tristetraprolin promotes insulin resistance through RNA destabilization of FGF21
- YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity
- FGF21 ameliorates diabetic cardiomyopathy by activating the AMPK-paraoxonase 1 signaling axis in mice
- FGF21 regulates insulin sensitivity following long-term chronic stress
- Membraneless reproducible MoS2 field-effect transistor biosensor for high sensitive and selective detection of FGF21
- Hepatic Crtc2 controls whole body energy metabolism via a miR-34a-FGF21 axis
- FGF21 induces autophagy‐mediated cholesterol efflux to inhibit atherogenesis via RACK1 up‐regulation
- FGF21-FGFR1 coordinates phospholipid homeostasis, lipid droplet function, and ER stress in obesity
- Mild cold exposure modulates fibroblast growth factor 21 (FGF21) diurnal rhythm in humans: relationship between FGF21 levels, lipolysis, and cold-induced …
- Acute hyperenergetic, high-fat feeding increases circulating FGF21, LECT2, and fetuin-A in healthy men
- Single ingestion of soy β-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects
- High plasma FGF21 levels predicts major cardiovascular events in patients treated with atorvastatin (from the Treating to New Targets [TNT] Study)
- Negative correlation between cerebrospinal fluid FGF21 levels and BDI scores in male Chinese subjects
- Long-acting hypoglycemic effects of PEGylated FGF21 and insulin glargine in mice with type 1 diabetes
- Heme-regulated eIF2α kinase modulates hepatic FGF21 and is activated by PPARβ/δ deficiency
- Contribution of serum FGF21 level to the identification of left ventricular systolic dysfunction and cardiac death
- Delayed recanalization at 3 days after permanent MCAO attenuates neuronal apoptosis through FGF21/FGFR1/PI3K/Caspase-3 pathway in rats
- High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice
- … scoparia extract attenuates non-alcoholic fatty liver disease in diet-induced obesity mice by enhancing hepatic insulin and AMPK signaling independently of FGF21 …
- KLF15‐activating Twist2 ameliorated hepatic steatosis by inhibiting inflammation and improving mitochondrial dysfunction via NF‐κB‐FGF21 or SREBP1c‐FGF21 …
- Mutual promotion of FGF21 and PPARγ attenuates hypoxia-induced pulmonary hypertension
- The protective effect of FGF21 on diabetes-induced male germ cell apoptosis is associated with up-regulated testicular AKT and AMPK/Sirt1/PGC-1α signaling
- Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non‐alcoholic fatty liver disease by up‐regulating the FGF21/PGC‐1α pathway
- Circulating FGF19 and FGF21 surge in early infancy from infra-to supra-adult concentrations
- The suitability of FGF21 and FGF23 as new biomarkers in endometrial cancer patients
- Exercise ameliorates the FGF21–adiponectin axis impairment in diet-induced obese mice
- The effect of eight weeks high intensity interval training (HIIT) on serum amounts of FGF21 and irisin in sedentary obese women
- Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARα-FGF21 axis
- Elevated FGF21 leads to attenuated postnatal linear growth in preterm infants through GH resistance in chondrocytes
- Roux-en-Y gastric bypass surgery has unique effects on postprandial FGF21 but not FGF19 secretion
- Adiponectin—a mediator of specific metabolic actions of FGF21
- FGF21 increases cholesterol efflux by upregulating ABCA1 through the ERK1/2–PPARγ–LXRα pathway in THP1 macrophage-derived foam cells
- Cord blood FGF21 in gestational diabetes and its relationship with postnatal growth
- Alternate-day fasting alleviates diabetes-induced glycolipid metabolism disorders: roles of FGF21 and bile acids
- Bitter melon extract attenuating hepatic steatosis may be mediated by FGF21 and AMPK/Sirt1 signaling in mice
- The FGF21 response to fructose predicts metabolic health and persists after bariatric surgery in obese humans
- Recruitment of histone methyltransferase G9a mediates transcriptional repression of FGF21 gene by E4BP4 protein
- Hepatic FGF21 production is increased in late pregnancy in the mouse
- Brown adipose tissue and browning agents: irisin and FGF21 in the development of obesity in children and adolescents
- REV-ERBα regulates FGF21 expression in the liver via hepatic nuclear factor 6
- Pemafibrate prevents retinal pathological neovascularization by increasing FGF21 level in a murine oxygen-induced retinopathy model
- Inhibition of the ox-LDL-induced pyroptosis by FGF21 of human umbilical vein endothelial cells through the TET2-UQCRC1-ROS pathway
- Fibroblast growth factor 21 (FGF21) protects against high fat diet induced inflammation and islet hyperplasia in pancreas
- Bone marrow mesenchymal stem cells: fat on and blast off by FGF21
- FGF21 protects human umbilical vein endothelial cells against high glucose-induced apoptosis via PI3K/Akt/Fox3a signaling pathway
- Suppression of Nrf2 attenuates adipogenesis and decreases FGF21 expression through PPAR gamma in 3T3-L1 cells
- HDAC3 inhibition in diabetic mice may activate Nrf2 preventing diabetes-induced liver damage and FGF21 synthesis and secretion leading to aortic protection
- … intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway: a meta …
- Serum FGF21 and RBP4 levels in patients with chronic hepatitis C
- Pharmacological efficacy of FGF21 analogue, liraglutide and insulin glargine in treatment of type 2 diabetes
- FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in …
- The effects of high intensity interval training on serum levels of FGF21 and insulin resistance in obese men
- Fibroblast growth factor 21 (FGF21) inhibits macrophage-mediated inflammation by activating Nrf2 and suppressing the NF-κB signaling pathway
- FGF21 promotes endothelial cell angiogenesis through a dynamin-2 and Rab5 dependent pathway
- Novel sandwich immunoassays for the measurement of total and active FGF21
- Increased leptin, decreased adiponectin and FGF21 concentrations in adolescent offspring of women with gestational diabetes
- Time‐restricted feeding alleviates cardiac dysfunction induced by simulated microgravity via restoring cardiac FGF21 signaling
- Valproic acid and other HDAC inhibitors upregulate FGF21 gene expression and promote process elongation in glia by inhibiting HDAC2 and 3
- Changes in plasma concentrations and mRNA expression of hepatokines fetuin A, fetuin B and FGF21 in physiological pregnancy and gestational diabetes …
- FGF21 reverses hepatic steatosis, increases energy expenditure and improves insulin sensitivity in diet-induced obese mice
- FGF21 is associated with metabolic effects and treatment response in depressed bipolar II disorder patients treated with valproate
- High FGF21 levels are associated with altered bone homeostasis in HIV-1-infected patients
- Exercise increases serum fibroblast growth factor 21 (FGF21) levels
- The cell adhesion molecule L1 regulates the expression of FGF21 and enhances neurite outgrowth
- Age‐related bone loss is associated with FGF21 but not IGFBP1 in healthy adults
- Commentary: FGF21 holds promises for treating obesity-related insulin resistance and hepatosteatosis
- A new FGF21 analog for the treatment of fatty liver disease
- Hepatic-specific PPARα-FGF21 action in NAFLD
- Effect of circulating glucagon and free fatty acids on hepatic FGF21 production in dairy cows
- Fibroblast growth factor 21 (FGF21) ameliorates collagen-induced arthritis through modulating oxidative stress and suppressing nuclear factor-kappa B pathway
- FGF21 protects against aggravated blood-brain barrier disruption after ischemic focal stroke in diabetic db/db male mice via cerebrovascular PPARγ activation
- Upregulation of rat liver PPARα‐FGF21 signaling by a docosahexaenoic acid and thyroid hormone combined protocol
- Optimization and characterization of a novel FGF21 mutant
- Interaction of glucocorticoids with FXR/FGF19/FGF21-mediated ileum-liver crosstalk
- Factors associated with cognitive impairment in elderly versus nonelderly patients with metabolic syndrome: the different roles of FGF21
- AKR-001, an Fc-FGF21 analog, showed sustained pharmacodynamic effects on insulin sensitivity and lipid metabolism in type 2 diabetes patients
- High-efficiency expression and secretion of human FGF21 in Bacillus subtilis by intercalation of a mini-cistron cassette and combinatorial optimization of cell …
- Fibroblast growth factor 21 (FGF21) inhibits chondrocyte function and growth hormone action directly at the growth plate
- Deficiency of fibroblast growth factor 21 (FGF21) promotes hepatocellular carcinoma (HCC) in mice on a long term obesogenic diet
- Therapeutic effect of dichloroacetate against atherosclerosis via hepatic FGF21 induction mediated by acute AMPK activation
- Activation of GR but not PXR by dexamethasone attenuated acetaminophen hepatotoxicities via FGF21 induction
- Diminished diet-induced hyperglycemia and dyslipidemia and enhanced expression of PPARa and FGF21 in mice with hepatic ablation of brain-derived …
- Protein intake and amino acid supplementation regulate exercise recovery and performance through the modulation of mTOR, AMPK, FGF21, and immunity
- … of circulating exosomes derived from normal-weight and obese women on gluconeogenesis, glycogenesis, lipogenesis and secretion of FGF21 and fetuin A …
- Hepatic c-Jun regulates glucose metabolism via FGF21 and modulates body temperature through the neural signals
- SIRT1 mediates effects of FGF21 to ameliorate cisplatin-induced acute kidney injury
- Alcohol ingestion induces pancreatic islet dysfunction and apoptosis via mediation of FGF21 resistance
- Alterations in Hepatic FGF21, Co-Regulated Genes, and Upstream Metabolic Genes in Response to Nutrition, Ketosis and Inflammation in Peripartal Holstein …
- FGF21 in ataxia patients with spinocerebellar atrophy and mitochondrial disease
- Glyco-engineered long acting FGF21 variant with optimal pharmaceutical and pharmacokinetic properties to enable weekly to twice monthly subcutaneous …
- Activation of AK005401 aggravates acute ischemia/reperfusion mediated hippocampal injury by directly targeting YY1/FGF21
- Recombinant Lactococcus lactis NZ3900 expressing bioactive human FGF21 reduced body weight of Db/Db mice through the activity of brown adipose tissue
- Weight loss and concomitant adipose autophagy in methionine-restricted obese mice is not dependent on adiponectin or FGF21
- Whole transcriptome analysis and validation of metabolic pathways in subcutaneous adipose tissues during FGF21-induced weight loss in non-human …
- The sum of all browning in FGF21 therapeutics
- Sterol 12α-hydroxylase aggravates dyslipidemia by activating the ceramide/mTORC1/SREBP-1C pathway via FGF21 and FGF15
- Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation
- Cardiac FGF21 synthesis and release: an autocrine loop for boosting up antioxidant defenses in failing hearts
- Sex dimorphism in the FGF21 gene expression in liver and adipose tissues is dependent on the metabolic condition
- Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21
- TGF-β2, EGF, and FGF21 growth factors present in breast milk promote mesenteric lymph node lymphocytes maturation in suckling rats
- FGF21 decreases food intake and body weight in obese Göttingen minipigs
- Glucagon-dependent suppression of mTORC1 is associated with upregulation of hepatic FGF21 mRNA translation
- Ampelopsin improves insulin resistance by activating PPARγ and subsequently up-regulating FGF21-AMPK signaling pathway
- FGF21 exerts comparable pharmacological efficacy with Adalimumab in ameliorating collagen-induced rheumatoid arthritis by regulating systematic inflammatory …
- Srebp-1c/FGF21/Pgc-1α axis regulated by leptin signaling in adipocytes—possible mechanism of caloric restriction-associated metabolic remodeling of white adipose …
- Integrated Regulation of Hepatic Metabolism by Fibroblast Growth Factor 21 (FGF21) in Vivo
- Development of a long acting FGF21 analogue-albumin fusion protein and its anti-diabetic effects
- FGF21 protects against ox-LDL induced apoptosis through suppressing CHOP expression in THP1 macrophage derived foam cells
- FGF21 and glycemic control in patients with T1D
- FGF21 mediates the associations between exercise, ageing and glucose regulation
- The effect of two concurrent exercise modalities on serum concentrations of FGF21, irisin, follistatin, and myostatin in men with type 2 diabetes mellitus
- Insulin sensitizes FGF21 in glucose and lipid metabolisms via activating common AKT pathway
- Alteration in serum concentrations of FGF19, FGF21, and FGF23 in patients with urothelial carcinoma
- Reduced oxidative stress and enhanced FGF21 formation in livers of endurance-exercised rats with diet-induced NASH
- Alterations in 3-hydroxyisobutyrate and FGF21 metabolism are associated with protein ingestion–induced insulin resistance
- The effect of hydration status on plasma FGF21 concentrations in humans: A subanalysis of a randomised crossover trial
- FGF21 is dispensable for hypothermia induced by fasting in mice
- Role of PPAR in the control of torpor through FGF21-NPY pathway: from circadian clock to seasonal change in mammals
- Whey protein isolate inhibits hepatic FGF21 production, which precedes weight gain, hyperinsulinemia and hyperglycemia in mice fed a high-fat diet
- Metformin promotes cholesterol efflux in macrophages by up-regulating FGF21 expression: a novel anti-atherosclerotic mechanism
- Effects of central FGF21 infusion on the hypothalamus–pituitary–thyroid axis and energy metabolism in rats
- Fasting induces FGF21 in humans
- The metabolic hormone FGF21 is associated with endothelial dysfunction in hemodialysis patients
- Expression and purification of FGF21 in Pichia pastoris and its effect on fibroblast-cell migration
- Ethyl acetate extract of sappanwood alleviates experimental atherosclerosis in rats through changes in FGF21 and SREBP-2 expression
- Hypocaloric diet prevents the decrease in FGF21 elicited by high phosphorus intake
- Gene expression profiling reveals that PXR activation inhibits hepatic PPARα activity and decreases FGF21 secretion in male C57BL6/J mice
- … of a new HRI activator as a new strategy to improve high‐fat‐diet‐induced glucose intolerance, hepatic steatosis, and hypertriglyceridaemia through FGF21
- Metabolic hormone FGF21 is induced in ground squirrels during hibernation but its overexpression is not sufficient to cause torpor
- FGF21 improves the adipocyte dysfunction related to seipin deficiency
- Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21
- FGF21 inhibitor suppresses the proliferation and migration of human umbilical vein endothelial cells through the eNOS/PI3K/AKT pathway
- Fasting-induced FGF21 is repressed by LXR activation via recruitment of an HDAC3 corepressor complex in mice
- Ileal transposition surgery decreases fat mass and improves glucose metabolism in diabetic GK rats: possible involvement of FGF21
- Fibroblast growth factor 21 (FGF21) in human cerebrospinal fluid: relationship with plasma FGF21 and body adiposity
- Changes in FGF21 serum concentrations and liver mRNA expression in an experimental model of complete lipodystrophy and insulin-resistant diabetes
- Moderate-intensity continuous training improves FGF21 and KLB expression in obese mice
- Hepatic FGF21 expression is repressed after simvastatin treatment in mice
- High serum levels of FGF21 are decreased in bipolar mania patients during psychotropic medication treatment and are associated with increased metabolism …
- Sustained release of a GLP-1 and FGF21 dual agonist from an injectable depot protects mice from obesity and hyperglycemia
- Photoperiodic regulation of FGF21 production in the Siberian hamster
- Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury
- Mechanism for the effects of FGF21
- Hepatic STAMP2 mediates recombinant FGF21‐induced improvement of hepatic iron overload in nonalcoholic fatty liver disease
- Genetic fusion of human FGF21 to a synthetic polypeptide improves pharmacokinetics and pharmacodynamics in a mouse model of obesity
- LPS infusion suppresses serum FGF21 levels in healthy adult volunteers
- Reduced adiposity attenuates FGF21 mediated metabolic improvements in the Siberian hamster
- Expression and pharmacological evaluation of fusion protein FGF21-L-Fc
- Liver GCN2 controls hepatic FGF21 secretion and modulates whole body postprandial oxidation profile under a low-protein diet
- DEPP/DEPP1/C10ORF10 regulates hepatic glucose and fat metabolism partly via ROS‐induced FGF21
- Astragalus polysaccharides affect insulin resistance by regulating the hepatic SIRT1-PGC-1α/PPARα-FGF21 signaling pathway in male Sprague Dawley rats …
- Effects of EPA and lipoic acid supplementation on circulating FGF21 and the fatty acid profile in overweight/obese women following a hypocaloric diet
- Erratum. Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans. Diabetes 2008; 57: 1246–1253
- Parsing the potential neuroendocrine actions of FGF21 in primates
- Pegbelfermin (BMS‐986036), PEGylated FGF21, in patients with obesity and type 2 diabetes: results from a randomized phase 2 study
- FGF21 mediates the protective effect of fenofibrate against acetaminophen-induced hepatotoxicity via activating autophagy in mice
- Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 …
- PF-05231023, a long-acting FGF21 analogue, decreases body weight by reduction of food intake in non-human primates
- Intestinal serine protease inhibition increases FGF21 and improves metabolism in obese mice
- Digenic variants in the FGF21 signaling pathway associated with severe insulin resistance and pseudoacromegaly
- Cholesterol metabolism altered and FGF21 levels high after pediatric liver transplantation despite normal serum lipids
- … of Klothoβ (KLB) and fibroblast growth factor receptor-1 (FGFR1) in living cells reveal the fibroblast growth factor-21 (FGF21)-induced receptor complex
- Enhanced expression and distinctive characterization of a long-acting FGF21 and its potential to alleviate nonalcoholic steatohepatitis
- Restoration of leptin responsiveness in diet‐induced obese mice using an optimized leptin analog in combination with exendin‐4 or FGF21
- The Influence of Hypertensive Therapies on Circulating Factors: Clinical Implications for SCFAs, FGF21, TNFSF14 and TNF-α
- Successful glycemic control decreases the elevated serum FGF21 level without affecting normal serum GDF15 levels in a patient with mitochondrial diabetes
- FGF21 knockout mice generated using CRISPR/Cas9 reveal genetic alterations that may affect hair growth
- Decreased beige adipocyte number and mitochondrial respiration coincide with increased histone methyl transferase (G9a) and reduced FGF21 gene expression in …
- Two novel intronic polymorphisms of bovine FGF21 gene are associated with body weight at 18 months in Chinese cattle
- Increased HO‐1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21
- An Exome-Chip Association Analysis in Chinese Subjects Reveals a Functional Missense Variant of GCKR That Regulates FGF21 Levels
- Characterization and quantification of an fc-FGF21 fusion protein in rat serum using immunoaffinity LC-MS
- Changes in selected biochemical parameters (including FGF21) during subclinical and clinical ketosis in dairy cows
- Large-scale expression, purification, and glucose uptake activity of recombinant human FGF21 in Escherichia coli
- Effects of beta-conglycinin intake on circulating FGF21 levels and brown adipose tissue activity in Japanese young men: a single intake study and a …
- … okamurae extract ameliorates the hyperglycemia and body weight gain of db/db mice through regulation of the PI3K/Akt pathway and thermogenic factors by FGF21
- Baseline circulating FGF21 concentrations and increase after fenofibrate treatment predict more rapid glycemic progression in type 2 diabetes: results from the FIELD …
- Fibroblast Growth Factor 21 (FGF21) and Glucagon-Like Peptide 1 Contribute to Diabetes Resistance in Glucagon Receptor–Deficient Mice
- Modulation of the systemic immune response in suckling rats by breast milk TGF-β2, EGF and FGF21 supplementation
- Uric acid induced hepatocytes lipid accumulation through regulation of miR-149-5p/FGF21 axis
- The sweetest thing: regulation of macronutrient preference by FGF21
- Increased FGF21 in brown adipose tissue of tyrosine hydroxylase heterozygous mice: implications for cold adaptation
- FGF21 regulates melanogenesis in alpaca melanocytes via ERK1/2-mediated MITF downregulation
- Genetic variants flanking the FGF21 gene were associated with renal function in Chinese patients with type 2 diabetes
- FGF21 analogue shows promise in the clinic
- Fibroblast growth factor 21 (FGF21) and bone: is there a relationship in humans?
- The moderate essential amino acid restriction entailed by low-protein vegan diets may promote vascular health by stimulating FGF21 secretion
- Autofluorescence imaging of living pancreatic islets reveals fibroblast growth factor-21 (FGF21)-induced metabolism
- Role of fibroblast growth factor 21 (FGF21) in undernutrition-related attenuation of growth in mice
- Pharmacologic inhibition of serotonin htr2b ameliorates hyperglycemia and the altered expression of hepatic FGF21, Sdf2l1, and htr2a in db/db mice and …
- FGF21 is associated with Acanthosis nigricans in obese patients
- The role of fibroblast growth factor 21 (FGF21) on energy balance, glucose and lipid metabolism
- Lower cerebrospinal fluid/plasma fibroblast growth factor 21 (FGF21) ratios and placental FGF21 production in gestational diabetes
- Berberine-induced activation of AMPK increases hepatic FGF21 expression via NUR77
- Agonistic β-Klotho antibody mimics fibroblast growth factor 21 (FGF21) functions
- … protein diet induces body weight loss and browning of subcutaneous white adipose tissue through enhanced expression of hepatic fibroblast growth factor 21 (FGF21)
- FGF21 regulates T-cell development in the neonatal and juvenile thymus
- miR-22 inhibition reduces hepatic steatosis via FGF21 and FGFR1 induction
- Differentiated embryo chondrocyte 1 (DEC1) is a novel negative regulator of hepatic fibroblast growth factor 21 (FGF21) in aging mice
- Role of adipokines FGF21, leptin and adiponectin in self-concept of youths with obesity
- Increased expression of fibroblast growth factor 21 (FGF21) during chronic undernutrition causes growth hormone insensitivity in chondrocytes by inducing …
- Klotho, FGF21 and FGF23: novel pathways to musculoskeletal health?
- Fasting-induced G0/G1 switch gene 2 and FGF21 expression in the liver are under regulation of adipose tissue derived fatty acids
- Highly selective and sensitive measurement of active forms of FGF21 using novel immunocapture enrichment with LC–MS/MS
- Fasting insulin and alanine amino transferase, but not FGF21, were independent parameters related with irisin increment after intensive aerobic exercising
- Hepatic stearoyl CoA desaturase 1 deficiency increases glucose uptake in adipose tissue partially through the PGC-1α–FGF21 axis in mice
- Associations between FGF21, osteonectin and bone turnover markers in type 2 diabetic patients with albuminuria
- A tryptophan hydroxylase inhibitor decreases hepatic FGF21 expression and circulating FGF21 in mice fed a high-fat diet
- FGF21 and its Relationship with Inflammatory and Metabolic Parameters in HIV Patients after Antiretroviral Treatment
- Chronic activation of PPARα with fenofibrate reduces autophagic proteins in the liver of mice independent of FGF21
- Hepatic FGF21 mediates tissue tolerance during bacterial inflammation by preserving cardiac function
- Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice
- Therapeutic approaches to Alzheimer’s type of dementia: a focus on FGF21 mediated neuroprotection
- Mediterranean Tomato‐Based Sofrito Sauce Improves Fibroblast Growth Factor 21 (FGF21) Signaling in White Adipose Tissue of Obese ZUCKER Rats
- In pursuit of a biomarker of weight gain susceptibility—is FGF21 a candidate?
- Metabolic responses to 24-hour fasting and mild cold exposure in overweight individuals are correlated and accompanied by changes in FGF21 concentration
- Effects of central fibroblast growth factor 21 (FGF21) in energy balance.
- Changes in liver gene expression and plasma concentration of Rbp4, Fetuin-A, and FGF21 in sprague-dawley rats subjected to different dietary interventions …
- α1-Adrenergic receptor downregulates hepatic FGF21 production and circulating FGF21 levels in mice
- FGF21 inhibits apolipoprotein (a) expression in HepG2 cells via the FGFR1-ERK1/2-Elk-1 pathway
- FGF21-protection against fructose-induced lipid accretion and oxidative stress is influenced by maternal nutrition in male progeny
- Circulating fibroblast growth factor 21 (FGF21) as diagnostic and prognostic biomarker in renal cancer
- Pulse wave velocity is associated with increased plasma oxLDL in ageing but not with FGF21 and habitual exercise
- Fibroblast growth factor-21 (FGF21) administration to early-lactating dairy cows. I. Effects on signaling and indices of insulin action
- Mapping the response of human fibroblast growth factor 21 (FGF21) promoter to serum availability and lipoic acid in HepG2 hepatoma cells
- FGF21 drives a shift in adipokine tone to restore metabolic health
- … cyanidin-3-glucoside attenuates high-fat-diet–induced body-weight gain and impairment of glucose tolerance in mice via effects on the hepatic hormone FGF21
- Therapeutic potential of FGF21 in diabetes
- A combined docosahexaenoic acid–thyroid hormone protocol upregulates rat liver β-Klotho expression and downstream components of FGF21 signaling as a …
- Maresin 1 regulates hepatic FGF21 in diet‐induced obese mice and in cultured hepatocytes
- Fibroblast growth factor 21 (FGF21) in children and adolescents with chronic kidney disease
- Balanced coagonist of GLP-1 and glucagon receptors corrects dyslipidemia by improving FGF21 sensitivity in hamster model
- The effect of vigorous aerobic exercise on serum levels of SIRT1, FGF21 and Fetuin A in women with type Ⅱ diabetes
- The swinging pendulum of biomarkers in mitochondrial disease: the role of FGF21
- Roles of FGF21 and irisin in obesity-related diabetes and pancreatic diseases
- The effect of high intensity interval training on serum levels of FGF21, insulin resistance and lipid profile in sedentary obese women
- Fibroblast Growth Factor 21 (FGF21) Gene Expression Is Elevated in the Liver of Mice Fed a High-Carbohydrate Liquid Diet and Attenuated by a Lipid Emulsion but Is …
- TCF4/β‑catenin complex is directly upstream of FGF21 in mouse stomach cancer cells
- Therapeutic role of fibroblast growth factor 21 (FGF21) in the amelioration of chronic diseases
- Predictive value of combined serum FGF21 and free t3 for survival in septic patients
- NS5ATP6 modulates intracellular triglyceride content through FGF21 and independently of SIRT1 and SREBP1
- Physiological and transcriptome analyses of transgenic FGF21 immature Rice seeds
- A common allele in FGF21 associated with preference for sugar consumption lowers body fat in the lower body and increases blood pressure
- Lipodystrophy HIV-related and FGF21: A new marker to follow the progression of lipodystrophy?
- Circulating CTRP1 levels in type 2 diabetes and their association with FGF21
- Plasma FGF21 concentrations, adipose fibroblast growth factor receptor-1 and β-klotho expression decrease with fasting in northern elephant seals
- Serum FGF21 in boys with idiopathic short stature: relationship to lipid profile, onset of puberty and growth
- Fibroblast growth factor-21 (FGF21) administration to early-lactating dairy cows. II. Pharmacokinetics, whole-animal performance, and lipid metabolism
- TRIB3 limits FGF21 induction during in vitro and in vivo nutrient deficiencies by inhibiting C/EBP–ATF response elements in the FGF21 promoter
- Thyroid hormone-induced expression of the hepatic scaffold proteins Sestrin2, β-Klotho, and FRS2α in relation to FGF21-AMPK signaling
- Cloning of goat FGF21 gene and its expression pattern in intramuscular adipocyte.
- Corrigendum to “ATF4-and CHOP-Dependent Induction of FGF21 through Endoplasmic Reticulum Stress”
- Is FGF23 or FGF21 a promising biomarker to indicate the aging process in COPD?
- FGF21 activation-mediated islet autophagy in Type 2 diabetes with pharmacotherapeutic potential
- Pharmacologic stimulation of central GLP-1 receptors has opposite effects on the alterations of plasma FGF21 levels induced by feeding and fasting
- TM-25659-induced activation of FGF21 level decreases insulin resistance and inflammation in skeletal muscle via GCN2 pathways
- FGF21 levels in pheochromocytoma/functional paraganglioma
- Moxibustion-simulating bipolar radiofrequency suppresses weight gain and induces adipose tissue browning via activation of UCP1 and FGF21 in a mouse …
- Serum levels of FGF21 and prediction of cardiovascular events
- FGF21, not GCN2, influences bone morphology due to dietary protein restrictions
- The good, the bad, and the unknown: Fructose and FGF21
- Relationship between Circulating FGF21 Concentrations and the Severity of Coronary Artery Damage in Subjects with Cardiovascular Disease
- Practical prospects for boosting hepatic production of the “pro-longevity” hormone FGF21
- Oral bezafibrate induces daily torpor and FGF21 in mice in a PPAR alpha dependent manner
- MS-275 induces hepatic FGF21 expression via H3K18ac-mediated CREBH signal
- Are you thirsty? FGF21 might be involved in that too
- Are Circulating FGF21 and NT-proBNP promising novel biomarkers in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?
- FGF21—the cause of having a’sweet tooth’?
- Higher increase degree of FGF21 post long-term interdisciplinary weight loss therapy preserves the free fat mass and rest metabolic rate in adolescents with …
- The Metabolic Effects of FGF21: From Physiology to Pharmacology
- FGF21 ACEs hypertension
- Study on the kidney impairment and expressions of FGF21 from a rat model of vascular calcification
- Plasma FGF21 levels in rats are dependent on dietary proteins but not on dietary carbohydrates or fats
- Mice lacking neutral amino acid transporter B⁰AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control
- IGFBP1—hepatokine and target for FGF21-mediated bone loss
- Levels of Fibroblast Growth Factor 21 (FGF21) in serum as diagnostic biomarker in patients with breast cancer
- Role of fibroblast growth factor 21 (FGF21) in the regulation of statural growth
- 1060-P: The Effect of FGF21/GLP-1 Fusion Protein on Glucose and Lipid Metabolism Using Diabetic Mice Models
- Comment on serum FGF21 and RBP4 levels in patients with chronic hepatitis C
- The effect of 8 weeks of aerobic exercise on serum levels of FGF21, Apolipoprotein A-1 and LDL-C to HDL-C ratio in obese women
- Methionine Restriction Alleviates Aging-related Cognitive Dysfunction via Stimulating FGF21-driven Mitochondrial Biogenesis (P14-026-19)
- The Role of FGF21 in Pancreatic Islet Metabolism
- Capparis spinosa improves the high fat diet-induced non-alcoholic steatohepatitis in rats: the possible role of FGF21
- The Effect of Eight Weeks of High Intensity Interval Training (HIIT) on Serum Irisin, FGF21 and Glycemic Indices in Type 2 Diabetic Women
- Comment on “FGF21 Response to Critical Illness: Effect of Blood Glucose Control and Relation With Cellular Stress and Survival” by Thiessen SE, et al
- Potential role for FGF21 as a mediator of thyroid hormone effects on metabolic regulation
- Divergent Metabolic and Cardiovascular Effects of FGF21
- Increase in FGF21 stimulates browning markers in white adipose tissue in rats fed a low protein high carbohydrate diet during acute cold exposure
- Link between FGF21 and blood pressure
- FGF21 inhibits lipid accumulation and inflammation induced by palmitate in human hepatocytes via SIRT1 pathway
- Effects of ethinylestradiol-cyproterone acetate vs. pioglitazone-flutamide-metformin on plasma FGF21 levels in adolescent girls with androgen excess
- Therapeutic Potential of FGF21 in Alzheimer’s Disease
- Evaluation of a cell model expressing βKlotho for screening FGF21 analogues
- PEG-FGF21 variant improves hepatic steatosis in a mouse model of NASH as determined by quantitative water-fat MRI
- Association of the 3′ UTR polymorphism (rs11665896) in the FGF21 gene with metabolic status and nutrient intake in children with obesity
- FGF21 levels in patients with breast cancer
- FGF21 inhibits adiponectin secretion in human adipocytes
- Pancreatitis: a loss of FGF21 function disease with potential for correction
- Effects of eight-week resistance training on serum level of βKlotho and FGF21 in diabetic women with non-alcoholic fatty liver disease
- A tryptophan hydroxylase inhibitor increases hepatic FGF21 production and decreases hepatic gluconeogenesis independently of insulin in db/db mice
- Astaxanthin Attenuates Hepatic Damages and Mitochondrial Dysfunction in Nonalcoholic Fatty Liver Disease by Regulating the FGF21/PGC-1α Pathway
- Key role for FGF21 in GLP1-mediated weight loss
- Mechanisms of action of methionine restriction and fibroblast growth factor 21 (FGF21)
- OR01-3 microRNA-34a-mediated FGF21 resistance in the adipose tissue contributes to insulin resistance and hypoadiponectinemia in diet-induced obesity
- Hepatic FGF21 is Under the Regulation of the Canonical Wnt Signaling Pathway
- The Role of FGF21 in Regulating Lipid and Glucose Metabolism
- Identification of a crucial amino acid responsible for the loss of specifying FGFR1–KLB affinity of the iodinated FGF21
- The Potential of Hibiscus sabdariffa Linn. for Treatment of Obesity: Focus on FGF21 in Liver and Adipose Tissue
- The Effect of Resistance Training with High and Moderate Intensities on Lipid Profile, Glycemic Index and FGF21 in Type 2 Diabetic Patients
- 370-OR: Hepatic FGF21 Expression Is Under the Regulation of the Canonical Wnt Signaling Pathway
- FGF21 determined angiogenic phenotypes in pulmonary endothelial cells
- P612 Involvement of the cardiomyokine FGF21 in protection against oxidative stress damage in the heart.
- The role of hepatic FGF21 (Fibroblast Growth Factor 21) in the maintenance of metabolic homeostasis during metabolic stress
- FGF21 action on human adipose tissue compromised by reduced βKlotho and FGFR1 expression in type 2 diabetes mellitus
- FGF21 alleviates neuroinflammation following ischemic stroke by modulating the temporal and spatial dynamics of microglia/macrophages
- Defective autophagy causes a maladaptive cardiac phenotype to exercise that leads to premature death and FGF21‐mediated protection against obesity and insulin …
- Protective Role of FGF21 in Adverse Cardiac Remodeling After Myocardial Infarction
- Effect of EPO on PRDM16, FGF21 expression and STAT phosphorylation of brown adipose tissue in HFD mice
- SREBP-1c knockdown attenuated fatty degeneration in hepatic L02 cells and inhibited CCL2 and FGF21 protein expression
- Positive correlations between and prediction of FGF21, adiponectin, leptin and NPY concentrations in the cerebrospinal fluid of Chinese subjects using back …
- GW29-e1353 A2A Receptor Activation Attenuates Hypertensive Cardiac Remodeling via Promoting Brown Adipose Tissue-Derived FGF21
- Construction of FGF21 knockout mouse models by the CRISPR/Cas9 system.
- Lack of FGF21 accelerates NASH-HCC transition via up-regulation of hepatic SPHK1-S1P-HIPPO signaling in murine models
- DOCTORAL DISSERTATION Translational Aspects of FGF21
- FGF21 and its Relationship with Inflammatory and Metabolic Parameters in HIV Patients after Antiretroviral Treatment
- Cloning and Expression Analysis of FGF21 Gene in Ctenopharyngodon idellus
- Restoring FGF21 reverses pancreatitis.
- Mechanisms and dynamics of mitochondrial disease stress responses: special emphasis on FGF21
- Altered FGF21 response in alcohol induced “Acute-on-chronic liver injury”(ACLI) model
- Expression, purification and characterization of recombinant canine FGF21 in Escherichia coli
- Therapeutic potential of FGF21 in cardiorenal syndrome
- Dietary protein and age-dependent female fertility: FGF21 trumps mTORC1
- The effects of eight weeks of resistance training on serum levels of FGF21, LCAT and LDL-C to HDL-C ratio in obese women
- Role of FGF21 and GCN2 in mediating the metabolic response to dietary protein restriction
- FGF21 Coordinates Adiponectin to Mediate the Beneficial Effects of Low-Protein Diet on Primordial Follicle Reserve
- Fibroblast Growth Factor 21 (FGF21) creates sugar-specific taste aversion to fructose through action in the brain in mice
- Effect of FGF21 on short-term white adipocyte adiponectin secretion
- An investigation of acute exercise and FGF21.
- The Liver-Derived Endocrine Hormone FGF21 Alters Metabolism and Diurnal Behavior via the Nervous System
- FGF21 prevents high fat diet-induced pancreatic cancer in mice expressing oncogenic Kras
- Regulation of the organokines FGF21 and chemerin by diet: metabolic and molecular effects in liver and adipose tissue of obese human subjects
- P1499 FGF21 CORRELATES POSITIVELY WITH ARTERIOVENOUS FISTULA OCCLUSION IN HEMODIALYSIS PATIENTS
- STUDIES ON THE REGULATION OF FGF21 GENE EXPRESSION BY (R)-α-LIPOIC ACID: MECHANISTIC INSIGHT INTO THE LIPID LOWERING PROPERTIES OF A …
- A2A Receptor Activation Attenuates Hypertensive Cardiac Remodeling Via Promoting Brown Adipose Tissue-Derived FGF21
- A Polymorphism in the FGF21 Gene is a Novel Risk Variant for Metabolic-Associated Steatohepatitis
- Expression of FGF21 and receptors FGFR1, FGFR2 in the first hair follicle growth cycle of mice.
- Association of FGF19, FGF21 and FGF23 with carbohydrate metabolism parameters and insulin resistance in patients with chronic kidney disease.
- FGF21 mediates corticosteroid-related bone mass loss through PPAR-
- O29: Régulation circadienne et nutritionnelle de FGF21 par PPARalpha
- Altered GDF15 and FGF21 Levels in Response to Strenuous Exercise: A Study in Marathon Runners
- Elevated FGF21 during insufficient sleep in active but not sedentary volunteers
- The secret life of FGF21
- FGF21 mediates the anti-depressant effects of exercise by coordinating the crosstalk between central and peripheral organs
- FGF21—central pathways of action unravelled
- Mistranslation drives alterations in protein levels and the effects of a synonymous variant at the FGF21 locus
- Factor-Associated Risk Factors of Mild Cognitive Impairment in Thalassemia Patients: Probable Role of FGF21
- Lack of FGF21 promotes NASH-HCC transition via exosome-mediated carcinogenetic signaling
- Fibroblast growth factor 21 (FGF21) in hyper-and hypothyroidism, association with metabolic disturbances
- FGF21: un lien entre reproduction et métabolisme
- FGF21 Expresses in Diabetic Hearts and Protects from Palmitate- and Diabetes-Induced Cardiac Cell Death In Vitro and In Vivo Via Erk1/2-Dependent P38 Mapk …
- FGF21 Prospects for Applications in Clinical Practice
- FGF21 restores photoreceptor function in type 1 diabetic mice
- FGF21: How sweet it is!
- mAb about FGF21
- Microglia-derived FGF21 as a modulator of astrocytic phenotype and cerebral ischemia injury
- Adipose and nonadipose effects of FGF21 delineated
- FGF21 as a Biomarker for Metabolic Stress in Heart Failure
- Effect of Moderate Aerobic Exercise on Serum Levels of FGF21 and Fetuin A in Women with Type 2 Diabetes
- The Physiology and Pharmacology of FGF21 in the Exocrine Pancreas
- The Consequences of LP Diet on Food Intake, Energy Expenditure and Hepatic and Hypothalamic FGF21 Are Reproduced by lLsine or Threonine Deficiency in Rats
- FGF21 action in the fat
- BIO89-100, a novel glycoPEGylated FGF21 Analog, Demonstrates Triglyceride Reduction and Broad Metabolic Effects in Spontaneously Diabetic Obese Cynomolgus …
- Correction for: Activation of AK005401 aggravates acute ischemia/reperfusion mediated hippocampal injury by directly targeting YY1/FGF21
- Ontogeny of FGF21 in the Human: Implications for Metabolic Health
- FGF21: A biomarker of neuromuscular diseases
- Regulation of glucose homeostasis by FGF21
- Comparison of Resistance, Aerobic and Combined Trainings Effects on the FGF21 Serum Levels in Active Elderly Men
- Regulation of Glucose Homeostasis by FGF21
- P3478 Glucose-dependent insulinotropic peptide is essential for maintenance of cardiac lipid metabolism via FGF21-dependent pathway
- Lack of FGF21 accelerates the Th17-IL-17 axis-mediated transition from nonalcoholic steatohepatitis to hepatocellular carcinoma
- The therapeutic effects of FGF21 on diabetic nephropathy are realized by augmenting autophagy via AMPK/mTOR signaling pathway
- FGF21 in acute and chronic alcohol consumption
- Fibroblast growth factor 21 (FGF21), free fatty acid (FFA), high sensitivity C-reactive protein (hsCRP) and homeostasis model assessment of insulin resistance (HOMA …
- FGF21 gets the juices flowing
- FGF21 prevented diabetic renal fibrosis
- Effect and mechanism of FGF21 on astrocyte damage induced by Aβ25-35
- FGF21 influences a’sweet tooth’in mice
- FGF21: starvation hormone to a clinical drug?
- 282-LB: Dysregulated FGF21 Links Hepatic Insulin Resistance to Dysfunctional BAT
- FGF21 Attenuates Neurodegeneration though Reducing Neuroinflammation and Oxidant-stress
- Mechanism of metabolic surgery mediated FGF21 in improving insulin resistance
- Glucagon Regulates Energy Balance via FGF21 Signaling in the Brain
- Pharmacological effects of recombinant FGF21 in ovariectomized mice C57Bl/6J
- The role of FGF21 in regulating energy homeostasis
- PPARα is a Key regulator of Hepatic FGF21 PPAR is a Key regulator of Hepatic FGF21
- Correlations between serum FGF21 and IRISIN levels and nutritional, biochemical, and anthropometric parameters in non-alcoholic fatty liver disease
- Expression of recombinant h-FGF21 in periplasmic space of Escherichia coli
- P rocess development of a FGF21 protein–antibody conjugate
- Regulation of FGF21 Gene Expression by Nutritional Signals and Physical Activity in vivo and in vitro
- Low protein/low methionine/high carbohydrate diets induce hyperphagia, increase energy expenditure and FGF21, but modestly affect adiposity in female BalbC mice.
- The physiology and pharmacology of the fasting-induced hormone, FGF21
- FGF21 improves glucose homeostasis in diabetes-prone NZO mice
- FGF21 in NASH and Liver Fibrosis
- Going hedonic-the role of FGF21 in the preference for sweet and alcohol
- FGF21 prevented diabetic renal fibrosis
- Mesenchymal Stem Cells Overexpressing FGF21 Improve Functional Recovery After Traumatic Brain Injury
- BIO89-100, a Novel Glycopegylated FGF21 Analogue, Demonstrates Robust Reduction in Serum Lipids and Long Half-life in a Phase 1 Randomized …
- Serum FGF21 Levels in Obese Korean Children and Adolescents (J Obes Metab Syndr 2017; 26: 204–9)
- Characterization of changes in temporal concentrations of fibroblast growth factor 21 (FGF21) before and after parturition in multiparous beef cows
- Metabolic Stress Hormone FGF21: From Physiology to Pharmacology
- Exercise, FGF21, and PGC-1: roles in hepatic metabolism
- The role of FGF21 in the metabolic response to amino acid restriction
- Hepatic FGF21 Expression Is Repressed after Simvastatin Treatment in Mice
- Hypocaloric Diet Prevents the Decrease in FGF21 Elicited by High Phosphorus Intake
- P27. The fasting hormone FGF21-an alternative therapy for Alzheimer’s disease?
- Dietary Carbohydrates but Not Proteins Are the Main Nutritional Determinant of FGF21 Production in Mice
- Synchronizing Metabolism, Physiology, and Behavior Through mTORC1 and FGF21
- Dietary Protein Restriction and FGF21 Influence Bone Morphology
- Translational Control of FGF21 mRNA Expression is Responsive to Nutritional Stress
- Effect of FGF21 on TLR4/p38MAPK Signaling Pathway in Nonalcoholic Fatty Liver Diseases of Rats
- Long-acting FGF21 inhibits retinal vascular leakage in vivo and in vitro model
- Patent: Methods of Treating FGF21-Associated Disorders
- 1957-P: Intermittent Ketogenic Diet Ameliorates Diet-Induced Obesity and Fatty Liver with Improved FGF21 Signaling
- Abstract WMP81: FGF21 Reduces Post-Stroke Blood Brain Barrier Damage in Diabetic db/db Male Mice
- FGF21 resistance in adipose tissues as a cause of insulin resistance?
- The impact of FGF21 on cardiac and whole-body energy metabolism
- Preface to special issue on ‘The hormone FGF21: a paramount actor of endocrine metabolic regulation, and even more’
- Relationship of FGF21 Levels With Major Cardiovascular Events in Patients Treated With Atorvastatin (From the Treating to New Targets [TNT] Study)
- The role of fibroblast growth factor 21 (FGF21) in the regulation and correction of carbohydrate and lipid metabolism
- Lactobacillus helveticus-MIKI-020 enhances hepatic FGF21 expression and decreases the core body temperature during sleep in mice
- FGF21 inhibits omentin expression in adipocytes
- The Protection of FGF21 on Chronic-Binge Alcohol-Induced Liver Injury
- Low Protein/low Methionine/high Carbohydrate Diets Induce Hyperphagia, Increase Energy Expenditure and FGF21, but Modestly Affect Adiposity in Female BalbC …
- Oral fructose does not acutely affect circulating FGF21 in mice
- Administration of FGF21 analogue ameliorates hyperglycemia in streptozotocin-induced diabetic mice
- 233-LB: Spinal Cord Injury Inhibited-FGF21 Signaling Is Associated with Dysregulation of Metabolic Gene Expression in Mouse Liver and Adipose Tissue
- KLB, Encoding the Co-receptor for FGF21, is Mutated in Congenital Hypogonadotropic Hypogonadism
- Preparation of Prokaryotic Expression Construct of Human FGF21 cDNA and Its Recombinant Protein Expression
- FGF21 Is Epigenetically Regulated by a Methyl Donor Rich Diet and a Transgenerational Model of IUGR.
- Effects of eight-week resistance training on serum level of β Klotho and FGF21 in diabetic women with non-alcoholic fatty liver disease
- Mitogenic response of human carcinoma cells to the liver-derived hormone FGF21
- FGF21 promotes the growth and proliferation of melanoma cells through regulating intracellular fatty acid oxidation
- Induction of FGF21 by CO/PERK/ATF4 Pathway Mediates Metabolic Homeostasis
- Protection of FGF21 as well as metallothionein for high fat diet induced cardiomyocyte impairment.
- Estimation of FGF21 Concentration in Prepubertal Children with Growth Hormone Deficiency before and after 6 Months of Growth Hormone Treatment
- FGF21, irisin and other novel players in endocrine metabolic regulation
- 523: Fibroblast Growth Factor 21 (FGF21) protein levels in the placenta of macrosomic infants
- Cardiac Fibroblast-derived FGF21 is a Novel Therapeutic Target for Cardiac Pathological Remodeling
- Expression of FGF21 and β-Klotho regulate hepatic fibrosis through NF-κB and JNK pathways
- Serum FGF21 Levels in Obese Korean Children and Adolescents (J Obes Metab Syndr 2017; 26: 204-9)
- Protein restriction induces FGF21-dependent mechanisms that are distinct from dietary restriction to protect mice from high-fat diet-induced obesity and glucose …
- 1833-P: A Novel Genetic Modified and Pegylated FGF21 Analog for the Treatment of Nonalcoholic Steatohepatitis in Nonhuman Primates
- Central resitin infusion impairs FGF21/FGFR1/β-Klotho hypothalamic expression and promotes peripheral FGF21 resistance: involvement of resistin/TLR4 signalling …
- Serum levels of FGF21 are reduced and negatively correlated with adiponectin in children with Prader-Willi syndrome
- Autophagy, FGF21 and glucagon during critical illness: interactions and therapeutic perspectives
- The Effects of Obesity, Weight Loss, and Weight Gain on Thymic Expression of FGF21
- FGF21 regulates circadian behavior and metabolism by acting on the nervous system
- The Carbohydrate-and Alcohol Intakes Associated FGF21 Genotype, Change in Alcohol Consumption, and Weight Change
- Association of serum FGF21 levels with clinical parameters in elder patients with type 2 diabetes.
- Towards Examining FGF21 Secretion from Pancreatic Islets in a Microfluidic Device
- High Casein Diet Differentially Alters FGF21 Levels in Plasma and Cardiac Tissue in Rats
- Fructose ingestion acutely stimulates circulating FGF21 levels in humans
- Effects of Hydroalcoholic Extract of Sargassum Oligocystum on Serum Concentration of SIRT1 and FGF21 in Streptozotocin Induced Diabetic Rat
- P107: NLRP3 inflammasome activation in macrophages suppresses FGF21 production in hepatocytes
- Potential role of FGF21 in the metabolic pathophysiology of an ovine model of polycystic ovary syndrome
- Skeletal muscle mitochondrial uncoupling induces a metabolic rescue cycle involving FGF21 as a myokine
- Hepatic regulation of VLDL receptor by PPARb/d and FGF21 modulates non-alcoholic fatty liver disease
- 227-LB: Dietary Protein Restriction Induced–FGF21 Improves Metabolic Health during Aging
- Association between Serum FGF21 levels and bone mineral density in healthy postmenopausal Korean women
- Circulating FGF21 in humans is potently induced by short term overfeeding of carbohydrates
- Research progress on glycolipid metabolism regulating of FGF19 and FGF21 in adipose tissue
- Cord Blood FGF21 and Leptin as Candidate Biomarkers of Early Infant Linear Growth Velocity in a Low‐Income Country
- Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin 2 resistant mouse models—-Association with liver and adipose tissue effects 3
- THE EFFECT OF ONE SESSION OF ENDURANCE TRAINING ON SERUM LEVELS OF FGF21 AND INSULIN RESISTANCE IN SEDENTARY WOMEN
- Nutritional regulation of the hepatokine FGF21 in the liver: interdependence of the transcription factors ChREBP and PPARα
- Oral recombinant Lactococcus lactis NZ3900 expressing bioactive human FGF21 reduced body weight of DbDb mice through the activity of brown adipose tissue
- SUN-253 FGF21 correlates positively with arteriovenous fistula occlusion in hemodialysis patients
- MUSCLE-RELATED miRNAS AND ITS RELATIONSHIP WITH CIRCULATING GDF15 AND FGF21 LEVELS IN PATIENTS WITH CARDIAC CACHEXIA
- Heme Oxygenase-PPARα Induction of FGF21 in Hepatocytes Recruits pAMPK/pAKT and Attenuates Insulin Resistance in Obese Mice
- … Children and Adolescents Have Higher Bone Mineral Density Than Normal Weighted Controls but Lower than Metabolically Healthy Obeses: No Effect of FGF21 …
- LY2405319, a analog of FGF21 ameliorates α-SMA production through inhibition of succinate-GPR91 pathway in mice
- GW26-e1025 Fenofibrate Prevention of Diabetic Cardiomyopathy Is Mediated by FGF21 Via Sirt1-Dependent Autophagy Modulation
- Pterostilbene inhibits palmitate-induced lipid deposition in L6 myotubes by modulating PLIN5/FGF21 pathway.
- … ARTICLE by a Recently Elected Academy Member: Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21
- PO-163 Aerobic exercise activates myocardial FGF21/FGFR1/PI3K-AKT signaling pathway and inhibits cardiomyocyte apoptosis in post-myocardial infarction rats
- Thyroid Hormone-Induced Expression of the Hepatic Scaffold Proteins Sestrin2, β-Klotho, and FRS2α in Relation to FGF21-AMPK Signaling
- Impacts of prenatal FGF21 upregulation on the thermogenic gene expression in the white adipose tissues of male C57BL/6J mice at adult stages
- Vildagliptin Attenuates Cardiac Hypertrophy and Improves Ventricular Efficiency Through FGF21 Expression in Pressure-overloaded Mouse Heart
- 1811-P: Induction of Hepatic Steatosis by a Methionine Choline Deficient Diet Promotes FGF21-Induced Insulin Secretion Independent of Diabetes
- Effect of a bout of acute cold water immersion on circulating FGF21, Irisin and T3 hormones in SCUBA divers
- Decreased beige adipocyte number and mitochondrial respiration coincide with reduced FGF21 gene expression in Sprague Dawley rats fed prenatal low protein and …
- Inhibition of insulin resistance by PGE1 via autophagy-dependent FGF21 pathway in diabetic nephropathy Wei Wei, Xing-rong An, Shi-Jie Jin, Xiao-Xue Li, Ming Xu
- Role of PPARα in control of torpor through FGF21-NPY pathway: From circadian clock genes to seasonal change and cardiovascular disease
- The Circulating Furan Fatty Acid Metabolite CMPF Directly Enhances Hepatic FGF21 Secretion and Lipid Metabolism
- FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in …
- Withdrawal: Increased expression of fibroblast growth factor 21 (FGF21) during chronic undernutrition causes growth hormone insensitivity in chondrocytes by …
- High Intensity Aerobic Exercise Activates Hepatic Fatty Acid Metabolism Related to PPARalpha-CREBH-FGF21 Axis in Non-alcoholic Fatty Liver Mice Rater than …
- BIO89-100, a GlycoPEGylated FGF21 Analog, Improved Serum Lipids and Extended Half-Life in a Controlled Single Ascending Dose Trial in Healthy Subjects
- Resveratrol stimulation of SIRT1 & exogenous delivery of FGF21 mimics metformin’s ability to alleviate non-alcoholic fatty liver disease caused by diet-induced obesity
- Fibroblast growth factor 21 (FGF21) response in alcohol induced “acute-on-chronic liver injury”(ACLI) model
- 222-LB: Diabetes Induces Liver Inflammation and FGF21 through C-Jun NH2-Terminal Kinase Pathways
- Fibroblast Growth Factor 21 (FGF21) Mouse (E. coli), Tagless
- 1896-P: Adipocyte-Derived Fibroblast Growth Factor 21 (FGF21) Contributes to Circulating FGF21 Pools in Diet-Induced Obese Mice
- Defining the role of Fibroblast growth factor 21 (FGF21) in the pathogenesis of growth hormone resistance and subsequent growth failure in chronic childhood …
- Understanding the Molecular Basis for FGF15/19 and FGF21 Actions on Energy Homeostasis
- Hormonal Responses that Regulate the Metabolic Benefits of Exercise: The Contribution of the Melanocortin System and the Fibroblast Growth Factor 21 (FGF21) …
- … factor 21 (FGF21) coupled with reduced adipose tissue BetaKlotho and FGF21 receptor 1 (FGFR1) expression in Type 2 diabetes may in part explain FGF21 …
- Fibroblast Growth Factor 21 (FGF21) Mouse (E. coli), His-Tagged
- Pharmaceutical inactivation of Erk1/2 does not affect function of FGF21 to regulate glucose and lipid metabolic hemostasis
- R‐α‐lipoic acid potentiates fasting‐induced transcription and secretion of hepatic fibroblast growth factor 21 (FGF21)
- Fibroblast growth factor 21 (FGF21) has a beneficial effect on carbohydrate and lipid metabolism and taste preferences in male and female mice with diet-induced …
- … protein diet induces body weight loss and browning of subcutaneous white adipose tissue through enhanced expression of hepatic fibroblast growth factor 21 (FGF21 …
- Fibroblast growth factor 21 (FGF21) and diabetes-induced vascular disease
- Anti-adiposity impact of phosphodiesterase-5 inhibitor, Sildenafil is possibly through browning of white adipose tissue and FGF21 in obese rats
- Fibroblast Growth Factor 21 (FGF21) Human (E. coli), Tagless
- MON-163 Lowering of Circulating FGF21 by Modulation of Bile Acid Metabolism in Healthy Males
- The mechanistic role of Fibroblast growth factor 21 (FGF21) in Growth Hormone resistance secondary to chronic childhood conditions
- Sulforaphane Downregulates Hepatic Fibroblast Growth Factor 21 (FGF21) of Diet Induced Obese Mice
- The role of the G-protein coupled receptor 120 (GPR120) on the FGF21 system in white and brown adipose tissues
- Undernutrition and Growth Failure: Is Fibroblast Growth Factor 21 (FGF21) The Missing Link
- Aerobic and Resistance Exercises Modulate Fibroblast Growth Factor-21 (FGF21) Level in Menopause Women with Type II Diabetic
- Fibroblast Growth Factor 21 (FGF21) Human (E. coli), His-Tagged
- Differentiated embryo chondrocyte1 (DEC1) is a novel negative regulator of hepatic Fibroblast growth factor 21 (FGF21) in aging mice
- Combination of metformin plus orlistat prevents tumor progression: novel role of the metabolic hormone fibroblast growth factor 21 (FGF21)
- Reply to Correspondence HEP-15-1008 “AHR-FGF21 dissociation of fatty liver from insulin resistance: a timely matter?”
- The role of metabolic hormone fibroblast growth factor 21 (FGF21) in mammalian hibernation using transgenic ground squirrels
- Research Article Circulating CTRP1 Levels in Type 2 Diabetes and Their Association with FGF21
- 301-LB: Effects of Amino Acid Restriction on Development of Type 2 Diabetes in NZO Mice by FGF21 Secretion
- 300-LB: FGF21 and a ß3-Adrenergic Agonist Synergistically Lower Blood Glucose in Obese Mice at Thermoneutrality
