RAPAMYCIN (MTOR INHIBITION) | Interstellar Blends

NON OPIOD ANALGESICS

March 22, 2021

Isoflavones

March 22, 2021

Mechanism of action of the immunosuppressant Rapamycin
Rapamycin in transplantation: a review of the evidence
Rapamycin: Clinical Results and Future Opportunities1
Targets for cell cycle arrest by the immunosuppressant Rapamycin in yeast
The target of Rapamycin (TOR) proteins
Solubilization of Rapamycin
Rapamune (Sirolimus, Rapamycin): an overview and mechanism of action.
Total synthesis of Rapamycin
Activity of Rapamycin (AY-22, 989) against transplanted tumors
Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k
SDZ RAD, a new Rapamycin derivative: pharmacological properties in vitro and in vivo
Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase
Regulation of cellular growth by the Drosophila target of Rapamycin dTOR
Bench to bedside: the development of Rapamycin and its application to stent restenosis
Rapamycin (AY-22, 989), a new antifungal antibiotic II. Fermentation, isolation and characterization
Two TOR complexes, only one of which is Rapamycin sensitive, have distinct roles in cell growth control
Rapamycin (AY-22, 989), a new antifungal antibiotic I. Taxonomy of the producing streptomycete and isolation of the active principle
The Rapamycin-sensitive signal transduction pathway as a target for cancer therapy
A mammalian protein targeted by G1-arresting Rapamycin–receptor complex
Rapamycin inhibits vascular smooth muscle cell migration.
TOR mutations confer Rapamycin resistance by preventing interaction with FKBP12-Rapamycin
Isolation of a protein target of the FKBP12-Rapamycin complex in mammalian cells
Rapamycin selectively represses translation of the” polypyrimidine tract” mRNA family
Phosphorylation of the translational repressor PHAS-I by the mammalian target of Rapamycin
Rapamycin: distribution, pharmacokinetics and therapeutic range investigations: an update.
Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor
Elucidating TOR signaling and Rapamycin action: lessons from Saccharomyces cerevisiae
Biosynthesis of erythromycin and Rapamycin
Blood distribution of Rapamycin.
Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of Rapamycin
Regulation of hypoxia-inducible factor 1α expression and function by the mammalian target of Rapamycin
Studies on the mechanism of resistance to Rapamycin in human cancer cells
A Rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus
Rapamycin: distribution, pharmacokinetics, and therapeutic range investigations.
Rapamycin blocks tumor progression: unlinking immunosuppression from antitumor efficacy1
Structure of the FKBP12-Rapamycin complex interacting with binding domain of human FRAP
Expression and disruption of the Arabidopsis TOR (target of Rapamycin) gene
Rapamycin enhances apoptosis and increases sensitivity to cisplatin in vitro
The biosynthetic gene cluster for the polyketide immunosuppressant Rapamycin
Mammalian target of Rapamycin (mTOR): pro-and anti-apoptotic
SDZ RAD, a new Rapamycin derivative: synergism with cyclosporine
Rapamycin (AY-22, 989), A NEW ANTIFUNGAL ANTIBIOTIC III. IN VITRO AND IN VIVO EVALUATION
RAFT1: a mammalian protein that binds to FKBP12 in a Rapamycin-dependent fashion and is homologous to yeast TORs
p53/p21CIP1 cooperate in enforcing Rapamycin-induced G1 arrest and determine the cellular response to Rapamycin
Raptor, a binding partner of target of Rapamycin (TOR), mediates TOR action
Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase
The principal target of Rapamycin‐induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.
Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases
The immunosuppressant Rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation
Rapamycin-FKBP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells
TOR kinase domains are required for two distinct functions, only one of which is inhibited by Rapamycin
inhibition of cell cycle progression by Rapamycin induces T cell clonal anergy even in the presence of costimulation
Revised NMR assignments for Rapamycin
Rapamycin blocks the phosphorylation of 4E‐BP1 and inhibits cap‐dependent initiation of translation.
Absorption and intestinal metabolism of SDZ-RAD and Rapamycin in rats
Rapamycin resistance tied to defective regulation of p27Kip1.
RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/Rapamycin complex
Targeted disruption of p70s6k defines its role in protein synthesis and Rapamycin sensitivity
Target of Rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression
Rapamycin prolongs survival and arrests pathophysiologic changes in murine systemic lupus erythematosus
Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins
SIROLIMUS (Rapamycin)-BASED THERAPY IN HUMAN RENAL TRANSPLANTATION: Similar Efficacy and Different Toxicity Compared with Cyclosporine: 1, 2
Inhibitors of mammalian target of Rapamycin as novel antitumor agents: from bench to clinic
Cytoplasmic–nuclear shuttling of FKBP12-Rapamycin-associated protein is involved in Rapamycin-sensitive signaling and translation initiation
A protein kinase B-dependent and Rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification
Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability
A chemical genomics approach toward understanding the global functions of the target of Rapamycin protein (TOR)
Mechanism of metabolic control: target of Rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors
Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a Rapamycin-sensitive pathway
inhibition of human B lymphocyte cell cycle progression and differentiation by Rapamycin
Mammalian target of Rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on …
Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or Rapamycin.
Cyclosporin A, FK506 and Rapamycin: more than just immunosuppression
Rapamycin inhibits human adipocyte differentiation in primary culture
Rapamycin impairs recovery from acute renal failure: role of cell-cycle arrest and apoptosis of tubular cells
inhibition of T and B lymphocyte proliferation by Rapamycin.
Target of Rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation
Partitioning the transcriptional program induced by Rapamycin among the effectors of the Tor proteins
Rapamycin (AY-22, 989), A NEW ANTIFUNGAL ANTIBIOTIC IV. MECHANISM OF ACTION
Control of translation by the target of Rapamycin proteins
Control of Ser2448 phosphorylation in the mammalian target of Rapamycin by insulin and skeletal muscle load
Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of Rapamycin mediated by a protein kinase B signaling pathway
Serum‐stimulated, Rapamycin‐sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI
Rapamune®(RAPA, Rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle …
Regulation of Ribosome Biogenesis by the Rapamycin-sensitive TOR-signaling Pathway in Saccharomyces cerevisiae
Enhancement of human platelet aggregation and secretion induced by Rapamycin.
A Rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1
Biochemical correlates of mTOR inhibition by the Rapamycin ester CCI-779 and tumor growth inhibition
The mammalian target of Rapamycin regulates C2C12 myogenesis via a kinase-independent mechanism
Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via Rapamycin (mTOR)‐dependent signaling
Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites
Immunopurified mammalian target of Rapamycin phosphorylates and activates p70 S6 kinase α in vitro
The principal Rapamycin-sensitive p70 (s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by Rapamycin-insensitive kinase kinases.
Direct inhibition of the signaling functions of the mammalian target of Rapamycin by the phosphoinositide 3‐kinase inhibitors, wortmannin and LY294002.
The Rapamycin-binding domain governs substrate selectivity by the mammalian target of Rapamycin
Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells
Interaction of RAFT1 with gephyrin required for Rapamycin-sensitive signaling
Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells
Suppression of B cell activation by cyclosporin A, FK506 and Rapamycin
Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins
Rapamycin and FK506 binding proteins (immunophilins)
Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis
On the chemistry and high field nuclear magnetic resonance spectroscopy of Rapamycin
Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and Rapamycin
Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, Rapamycin and cyclosporin A
Activated mammalian target of Rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors
inhibition of the mammalian target of Rapamycin sensitizes U87 xenografts to fractionated radiation therapy
Atomic structure of the Rapamycin human immunophilin FKBP-12 complex
The FKBP12-Rapamycin-binding domain is required for FKBP12-Rapamycin-associated protein kinase activity and G1 progression
A novel pathway regulating the mammalian target of Rapamycin (mTOR) signaling
Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the Rapamycin target mTOR
Mammalian target of Rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling
Rapamycin: a bone sparing immunosuppressant?
Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of Rapamycin
Mechanism of action of Rapamycin: New insights into the regulation of G1-phase progression in eukaryotic cells
Preclinical evaluation of a new potent immunosuppressive agent, Rapamycin.
Early clinical experience with a novel Rapamycin derivative
Antitumor activity of the Rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination …
AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of Rapamycin (mTOR) signaling
Total synthesis of Rapamycin and demethoxyRapamycin
Rapamycin induces the G0 program of transcriptional repression in yeast by interfering with the TOR signaling pathway
Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and Rapamycin in rat adipocytes
Synergistic interactions of cyclosporine and Rapamycin to inhibit immune performances of normal human peripheral blood lymphocytes in vitro.
Interaction between FKBP12-Rapamycin and TOR involves a conserved serine residue.
Comparison of acute Rapamycin nephrotoxicity with cyclosporine and FK506
Refined structure of the FKBP12–Rapamycin–FRB ternary complex at 2.2 Å resolution
Immunosuppressants FK506 and Rapamycin function as reversal agents of the multidrug resistance phenotype
Regulation of the cell integrity pathway by Rapamycin-sensitive TOR function in budding yeast
Rapamycin, a potent immunosuppressive drug, causes programmed cell death in B lymphoma cells
Sirolimus (Rapamycin) for the treatment of steroid-refractory acute graft-versus-host disease1
Hyperlipidemia in renal transplant recipients treated with sirolimus (Rapamycin)
Effects of Rapamycin on Ryanodine Receptor/Ca2+-Release Channels From Cardiac Muscle
Conversion to Rapamycin immunosuppression in renal transplant recipients: report of an initial Experience1
Global and specific translational control by Rapamycin in T cells uncovered by microarrays and proteomics
Synergistic effects of cyclosporine and Rapamycin in a chronic nephrotoxicity model1
Rapamycin inhibits constitutive p70s6k phosphorylation, cell proliferation, and colony formation in small cell lung cancer cells
Total synthesis of (-)-Rapamycin using an Evans-Tishchenko fragment coupling
FKBP12-Rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions
Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein.
Rapamycin blocks cell cycle progression of activated T cells prior to events characteristic of the middle to late G1 phase of the cycle
FKBP12-Rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction
Modulation of transcription of rRNA genes by Rapamycin
The effect of Rapamycin on kidney function in the Sprague-Dawley rat.
Organization of the biosynthetic gene cluster for Rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase
Growth-dependent translation of IGF-II mRNA by a Rapamycin-sensitive pathway
Effects of Rapamycin in experimental organ allografting.
Metabolic and autocrine regulation of the mammalian target of Rapamycin by pancreatic β-cells
Predominant nuclear localization of mammalian target of Rapamycin in normal and malignant cells in culture
Effect of nitrogen source on biosynthesis of Rapamycin by Streptomyces hygroscopicus
Rapamycin‐sensitive phase of 3T3‐L1 preadipocyte differentiation after clonal expansion
The mammalian target of Rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus
Rapamycin eluting stent: the onset of a new era in interventional cardiology
Efficacy of sirolimus (Rapamycin) administered concomitantly with a subtherapeutic dose of cyclosporin in the treatment of severe psoriasis: a randomized controlled …
B cell receptor-associated protein α4 displays Rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A
The immunosuppressant Rapamycin induces inactivation of p70s6k through dephosphorylation of a novel set of sites
Regulation of translational effectors by amino acid and mammalian target of Rapamycin signaling pathways: possible involvement of autophagy in cultured …
Molecular mechanisms of immunosuppression by cyclosporine, FK506, and Rapamycin.
… vascular smooth muscle cell DNA synthesis. inhibition of basic fibroblast growth factor and platelet-derived growth factor action and antagonism of Rapamycin by …
Mammalian target of Rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and …
Influence of cyclosporin, tacrolimus and Rapamycin on renal function and arterial hypertension after renal transplantation
Antifungal activities of Rapamycin and its derivatives, prolylRapamycin, 32-desmethylRapamycin, and 32-desmethoxyRapamycin
Rapamycin inhibits macropinocytosis and mannose receptor–mediated endocytosis by bone marrow–derived dendritic cells
Pharmacokinetics of Rapamycin.
The immunosuppressant Rapamycin represses human immunodeficiency virus type 1 replication
Treatment with Rapamycin and mycophenolic acid reduces arterial intimal thickening produced by mechanical injury and allows endothelial replacement.
Rapamycin inhibits arterial intimal thickening caused by both alloimmune and mechanical injury. Its effect on cellular, growth factor, and cytokine response in injured …
Rapamycin reverses chronic graft vascular disease in a novel cardiac allograft model
Total synthesis of Rapamycin via a novel titanium-mediated aldol macrocyclization reaction
Cyclosporin A, FK-506, and Rapamycin: pharmacologic probes of lymphocyte signal transduction
Enhancement of the antifungal activity of Rapamycin by the coproduced elaiophylin and nigericin
… X-ray structures of the major binding protein for the immunosuppressant FK506 (tacrolimus) in unliganded form and in complex with FK506 and Rapamycin
Mammalian target of Rapamycin-dependent phosphorylation of PHAS-I in four (S/T) P sites detected by phospho-specific antibodies
Rapamycin induces apoptosis in monocyte-and CD34-derived dendritic cells but not in monocytes and macrophages
Activation of mRNA translation in rat cardiac myocytes by insulin involves multiple Rapamycin-sensitive steps
Clinical development of mammalian target of Rapamycin inhibitors
Identification of an 11-kDa FKBP12-Rapamycin-binding domain within the 289-kDa FKBP12-Rapamycin-associated protein and characterization of a critical serine …
COMBINED COSTIMULATION BLOCKADE PLUS Rapamycin BUT NOT CYCLOSPORINE PRODUCES PERMANENT ENGRAFTMENT1
Effect of amino acids on Rapamycin biosynthesis by Streptomyces hygroscopicus
Rapamycin antifungal action is mediated via conserved complexes with fkbp12 and tor kinase homologs incryptococcus neoformans
Rapamycin-induced inhibition of p34cdc2 kinase activation is associated with G1/S-phase growth arrest in T lymphocytes.
Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate Rapamycin cytotoxicity.
… autophagy and activation of lysosome-dependent proteolysis in C2C12 myotubes through a mammalian target of Rapamycin-independent signaling pathway
Control of PHAS-I by insulin in 3T3-L1 adipocytes: synthesis, degradation, and phosphorylation by a Rapamycin-sensitive and mitogen-activated protein …
Stress-activated protein kinase-2/p38 and a Rapamycin-sensitive pathway are required for C2C12 myogenesis
Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR
Rapamycin (sirolimus, rapamune).
Organisation of the biosynthetic gene cluster for Rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase
Rapamycin selectively inhibits angiotensin II–induced increase in protein synthesis in cardiac myocytes in vitro: potential role of 70-kD S6 kinase in angiotensin II …
Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of Rapamycin-dependent signaling pathway
Resistance to Rapamycin: a novel anticancer drug
Carbon source nutrition of Rapamycin biosynthesis in Streptomyces hygroscopicus
Osteoblastic differentiation is enhanced by Rapamycin in rat osteoblast-like osteosarcoma (ROS 17/2.8) cells
Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of Rapamycin phosphorylation site
The Rapamycin analogue SDZ RAD attenuates bleomycin-induced pulmonary fibrosis in rats
Regulation of translation elongation factor‐2 by insulin via a Rapamycin‐sensitive signalling pathway.
The FKBP12‐Rapamycin‐associated protein (FRAP) is a CLIP‐170 kinase
Rapamycin selectively inhibits the growth of childhood rhabdomyosarcoma cells through inhibition of signaling via the type I insulin-like growth factor receptor
Molecular characterization of a plant FKBP12 that does not mediate action of FK506 and Rapamycin
Synergistic effect of Rapamycin and cyclosporin A in the treatment of experimental autoimmune uveoretinitis.
Rapamycin-insensitive regulation of 4e-BP1 in regenerating rat liver
Tuberous sclerosis complex-1 and-2 gene products function together to inhibit mammalian target of Rapamycin (mTOR)-mediated downstream signaling
Evidence that phosphorylation of human Upfl protein varies with intracellular location and is mediated by a wortmannin-sensitive and Rapamycin-sensitive PI 3-kinase …
Failure of hormone therapy in prostate cancer involves systematic restoration of androgen responsive genes and activation of Rapamycin sensitive signaling
Differential anti-inflammatory effects of immunosuppressive drugs: cyclosporin, Rapamycin and FK-506 on inducible nitric oxide synthase, nitric oxide, cyclooxygenase …
cAMP-and Rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells
A Rapamycin-selective 25-kDa immunophilin
FKBP12‐Rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol‐4 kinase activity.
Pharmacokinetics and safety of single oral doses of sirolimus (Rapamycin) in healthy male volunteers
Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and Rapamycin in 3T3-L1 adipocytes: evidence for the involvement …
The TOR (target of Rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae
Heat capacity changes and hydrophobic interactions in the binding of FK506 and Rapamycin to the FK506 binding protein
Attenuation of mammalian target of Rapamycin activity by increased cAMP in 3T3-L1 adipocytes
Rapamycin specifically interferes with the developmental response of fission yeast to starvation.
CD28 signaling causes a sustained down-regulation of I kappa B alpha which can be prevented by the immunosuppressant Rapamycin.
Incorporation of acetate, propionate, and methionine into Rapamycin by Streptomyces hygroscopicus
… Virus 1 Envelope Glycoprotein Complex-induced Apoptosis Involves Mammalian Target of Rapamycin/FKBP12-Rapamycin–associated Protein–mediated p53 …
The efficacy and toxicity of Rapamycin in murine islet transplantation. In vitro and in vivo studies.
Rapamycin partially prevents insulin resistance induced by chronic insulin treatment
Rapamycin potentiates transforming growth factor β-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells
Molecular mechanisms of action of new xenobiotic immunosuppressive drugs: tacrolimus (FK506), sirolimus (Rapamycin), mycophenolate mofetil and leflunomide
Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex
Prolongation of renal allograft survival in a large animal model by oral Rapamycin monotherapy.
The effect of a high‐fat meal on the oral bioavailability of the immunosuppressant sirolimus (Rapamycin)
Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a target of Rapamycin-dependent manner
SIROLIMUS (Rapamycin) HALTS AND REVERSES PROGRESSION OF ALLOGRAFT VASCULAR DISEASE IN NON-HUMAN PRIMATES1
The isolation, synthesis and characterization of an isomeric form of Rapamycin
Effects of cyclosporin, FK506, and Rapamycin on graft-vessel disease
… translational control of GLUT1 and GLUT4 glucose transporter mRNAs in response to insulin: role of mammalian target of Rapamycin, protein kinase b, and …
Rapamycin inhibition of interleukin-2-dependent p33cdk2 and p34cdc2 kinase activation in T lymphocytes.
A Unified Total Synthesis of the Immunomodulators (−)-Rapamycin and (−)-27-DemethoxyRapamycin: Assembly of the Common C (1− 20) Perimeter and Final …
Mechanism of the combination immunosuppressive effects of Rapamycin with either cyclosporine or tacrolimus
The antimicrobial activities of cyclosporine, FK506, and Rapamycin
Molecular cloning of a membrane-associated human FK506-and Rapamycin-binding protein, FKBP-13.
Contrasting impacts of immunosuppressive agents (Rapamycin, FK506, cyclosporin A, and dexamethasone) on bidirectional dendritic cell-T cell interaction during …
… new protein that forms specific complexes with both immunophilins FKBP59 and FKBP12: prevention by the immunosuppressant drugs FK506 and Rapamycin
Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and Rapamycin in man and rat.
Rapamycin Inhibits α1-Adrenergic Receptor–Stimulated Cardiac Myocyte Hypertrophy but Not Activation of Hypertrophy-Associated Genes: Evidence for Involvement …
FK506 and Rapamycin: novel pharmacological probes of the immune response
Target of Rapamycin
Mutagenesis of the Rapamycin producer Streptomyces hygroscopicus FC904
The effect of Rapamycin on T cell development in mice
The effects of Rapamycin in murine peripheral nerve isografts and allografts
4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to Rapamycin
A putative sirolimus (Rapamycin) effector protein
Rapamycin: In Vitro Profile of a New Immunosuppressive Macrolide.
The Upregulation of p27Kip1 by Rapamycin Results in G1 Arrest in Exponentially Growing T-Cell Lines
Generation of novel Rapamycin structures by microbial manipulations
Consensus guidelines for therapeutic drug monitoring of Rapamycin: report of the consensus panel
Comparative study of cyclosporine and tacrolimus vs newer immunosuppressants mycophenolate mofetil and Rapamycin on coronary endothelial function
Convergence of the target of Rapamycin and the Snf1 protein kinase pathways in the regulation of the subcellular localization of Msn2, a transcriptional …
FKBP-Rapamycin inhibits a cyclin-dependent kinase activity and a cyclin D1-Cdk association in early G1 of an osteosarcoma cell line.
Neointimal formation after balloon-induced vascular injury in Yucatan minipigs is reduced by oral Rapamycin
Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by Rapamycin-insensitive pathways in skeletal muscle …
Roles of peptidyl-prolyl cis-trans isomerase and calcineurin in the mechanisms of antimalarial action of cyclosporin A, FK506, and Rapamycin
Studies on the chemistry of Rapamycin: novel transformations under Lewis-acid catalysis
Rapamycin on trial
Effects of Rapamycin on cultured hepatocyte proliferation and gene expression
Therapeutic monitoring of Rapamycin: a new immunosuppressive drug.
Chlamydia trachomatis Mip‐like protein has peptidylprolyl cis/trans isomerase activity that is inhibited by FK506 and Rapamycin and is implicated in initiation of …
MID1 and MID2 homo-and heterodimerise to tether the Rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical …
Rapamycin (sirolimus) inhibits proliferating cell nuclear antigen expression and blocks cell cycle in the G1 phase in human keratinocyte stem cells.
Rapamycin prevents the onset of insulin‐dependent diabetes mellitus (IDDM) in NOD mice
Sensitive and specific quantification of sirolimus (Rapamycin) and its metabolites in blood of kidney graft recipients by HPLC/electrospray-mass spectrometry
… LYMPHOCYTES MAY DISTINGUISH CYCLOSPORINE EFFECT IN RENAL TRANSPLANT RECIPIENTS RECEIVING A CYCLOSPORINE+ Rapamycin REGIMEN1
Rapamycin, a potential disease-modifying antiarthritic drug.
The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a Rapamycin-sensitive point immediately …
Myogenic differentiation is dependent on both the kinase function and the N-terminal sequence of mammalian target of Rapamycin
Treatment of autoimmune uveoretinitis in the rat with Rapamycin, an inhibitor of lymphocyte growth factor signal transduction
Rapamycin, a potent immunosuppressive drug for vascularized heart, kidney, and small bowel transplantation in the rat.
lnterleukin-2-mediated elimination of the p27 Kipl cyclin-dependent kinase inhibitor prevented by Rapamycin
Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and Rapamycin
Ultraviolet-induced phosphorylation of p70S6K at Thr389 and Thr421/Ser424 involves hydrogen peroxide and mammalian target of Rapamycin but not Akt and atypical …
Toxicity of Rapamycin–a comparative and combination study with cyclosporine at immunotherapeutic dosage in the rat.
L-Asparaginase inhibits the Rapamycin-targeted signaling pathway
The Rapamycin and FKBP12 target (RAFT) displays phosphatidylinositol 4-kinase activity
The Target of Rapamycin Signaling Pathway Regulates mRNA Turnover in the Yeast Saccharomyces cerevisiae
Protein kinase activity and identification of a toxic effector domain of the target of Rapamycin TOR proteins in yeast
inhibition of in vitro immunoglobulin production by Rapamycin.
Rapamycin inhibits corneal allograft rejection and neovascularization
Base catalyzed degradations of Rapamycin
Rapamycin inhibits the generation of graft-versus-host disease-and graft-versus-leukemia-causing T cells by interfering with the production of Th1 or Th1 cytotoxic …
The immunosuppressive macrolides FK-506 and Rapamycin act as reciprocal antagonists in murine T cells.
Rapamycin: FK506’s fraternal twin or distant cousin?
Substrate specificity for the human rotamase FKBP: a view of FK506 and Rapamycin as leucine-(twisted amide)-proline mimics
Structure-activity studies of Rapamycin analogs: evidence that the C-7 methoxy group is part of the effector domain and positioned at the FKBP12-FRAP …
Rapamycin reduces hybridoma cell death and enhances monoclonal antibody production
A novel FK506-and Rapamycin-binding protein (FPR3 gene product) in the yeast Saccharomyces cerevisiae is a proline rotamase localized to the nucleolus.
p70s6k integrates phosphatidylinositol 3-kinase and Rapamycin-regulated signals for E2F regulation in T lymphocytes
DIFFERENTIAL EFFECTS OF CYCLOSPORINE A, METHYLPREDNISOLONE, MYCOPHENOLATE, AND Rapamycin ON CD154 INDUCTION AND REQUIREMENT …
Target of Rapamycin proteins and their kinase activities are required for meiosis
Rapamycin-FKBP12 blocks proliferation, induces differentiation, and inhibits cdc2 kinase activity in a myogenic cell line.
inhibition by Rapamycin of PDGF-and bFGF-induced human tenon fibroblast proliferation in vitro.
New process control strategy used in a Rapamycin fermentation
Tacrolimus-Rapamycin combination therapy for experimental autoimmune uveoretinitis
Serotonin Activates S6 Kinase in a Rapamycin-Sensitive Manner inAplysia Synaptosomes
A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of Rapamycin in mitogen-stimulated and transformed cells
Insulin regulates lipoprotein lipase activity in rat adipose cells via wortmannin-and Rapamycin-sensitive pathways
Phosphate, ammonium, magnesium and iron nutrition of Streptomyces hygroscopicus with respect to Rapamycin biosynthesis
Constitutive activation of S6 kinase by deletion of amino-terminal autoinhibitory and Rapamycin sensitivity domains.
Growth of Streptomyces hygroscopicus in rotating-wall bioreactor under simulated microgravity inhibits Rapamycin production
Structure of Rapamycin: an NMR and molecular‐dynamics investigation
40-O-(2-Hydroxyethyl)-Rapamycin Attenuates Pulmonary Arterial Hypertension and Neointimal Formation in Rats
The Drosophila p70s6k homolog exhibits conserved regulatory elements and Rapamycin sensitivity
Structure-activity studies of nonmacrocyclic Rapamycin derivatives
Gene disruption and replacement in the Rapamycin-producing Streptomyces hygroscopicus strain ATCC 29253
Production of synergistic but nonidentical mechanisms of immunosuppression by Rapamycin and cyclosporine.
A Unified Total Synthesis of the Immunomodulators (−)-Rapamycin and (−)-27-DemethoxyRapamycin: Construction of the C (21− 42) Perimeters
Design and Synthesis of a Rapamycin-based high affinity binding FKBP12 ligand
Synthetic investigations of Rapamycin. 2. Synthesis of a C (22)-C (42) fragment
The immunosuppressant Rapamycin, alone or with transforming growth factor-b, enhances osteoclast differentiation of RAW264. 7 monocyte-macrophage cells in the …
Origin and true nature of the starter unit for the Rapamycin polyketide synthase
… , p70 S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement of the mammalian target of Rapamycin (mTOR) pathway in the …
Impaired phosphate handling of renal allografts is aggravated under Rapamycin‐based immunosuppression
… in stereochemical communication: a strategy for the stereospecific synthesis and stabilization of the triene substructure of Rapamycin through sulfone substitution
TACROLIMUS (FK506) AND SIROLIMUS (Rapamycin) IN COMBINATION ARE NOT ANTAGONISTIC BUT PRODUCE EXTENDED GRAFT SURVIVAL IN CARDIAC …
Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and Rapamycin.
Raf/MAPK and Rapamycin-sensitive pathways mediate the anti-apoptotic function of p21Ras in IL-3-dependent hematopoietic cells
Rapamycin INDUCES TRANSFORMING GROWTH FACTOR-β PRODUCTION BY LYMPHOCYTES1
Insulin release and suppression by tacrolimus, Rapamycin and cyclosporin A are through regulation of the ATP‐sensitive potassium channel
… kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by Rapamycin: evidence that wortmannin …
The Pipecolate‐Incorporating Enzyme for the Biosynthesis of the Immunosuppressant Rapamycin—Nucleotide Sequence Analysis, Disruption and Heterologous …
Graft-versus-host disease prevention by Rapamycin: cellular mechanisms
Regulation of both glycogen synthase and PHAS-I by insulin in rat skeletal muscle involves mitogen-activated protein kinase-independent and Rapamycin …
Quantitative analysis of sirolimus (Rapamycin) in blood by high-performance liquid chromatography–electrospray tandem mass spectrometry
Potentiation of glucocorticoid receptor-mediated gene expression by the immunophilin ligands FK506 and Rapamycin.
Isolation of two immunosuppressive metabolites after in vitro metabolism of Rapamycin.
p-Glycoprotein-mediated transport of a fluorescent Rapamycin derivative in renal proximal tubule
Expression, enzyme activity, and subcellular localization of mammalian target of Rapamycin in insulin-responsive cells
Insulin regulation of glucose-6-phosphate dehydrogenase gene expression is Rapamycin-sensitive and requires phosphatidylinositol 3-kinase
Rapamycin blocks IL-2-driven T cell cycle progression while preserving T cell survival
Molecular cloning of a 25-kDa high affinity Rapamycin binding protein, FKBP25.
The immediate precursor of the nitrogen-containing ring of Rapamycin is free pipecolic acid
Cholestasis and regulation of genes related to drug metabolism and biliary transport in rat liver following treatment with cyclosporine A and sirolimus (Rapamycin)
A novel ring contraction of Rapamycin
Prolongation of canine pancreatic islet allograft survival with combined Rapamycin and cyclosporine therapy at low doses. Rapamycin efficacy is blood level related.
inhibition of liver, kidney, and intestine regeneration by Rapamycin
Ig receptor binding protein 1 (α4) is associated with a Rapamycin-sensitive signal transduction in lymphocytes through direct binding to the catalytic subunit of protein …
… of the International Society for Heart and Lung Transplantation working formulation for heart transplant biopsy specimens. Rapamycin Cardiac Rejection Treatment …
Effect of Rapamycin on the cyclosporin A–resistant CD28-mediated costimulatory pathway
Lack of change of cancellous bone volume with short-term use of the new immunosuppressant Rapamycin in rats
Studies towards the total synthesis of Rapamycin: A convergent and stereoselective synthesis of the C22 C32 carbon framework
Rapamycin and wortmannin enhance replication of a defective encephalomyocarditis virus
… factor and its transcriptional activator, hypoxia inducible factor-1α, through a pathway involving phosphoinositide 3-kinase and the mammalian target of Rapamycin
… acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by Rapamycin, and is independent …
Effect of p27 deficiency and Rapamycin on intimal hyperplasia: in vivo and in vitro studies using a p27 knockout mouse model
The effect of dexamethasone, cyclosporine, and Rapamycin on T-lymphocyte proliferation in vitro: comparison of cells from patients with glucocorticoid-sensitive and …
Rapamycin increases the cellular concentration of the BCL-2 protein and exerts an anti-apoptotic effect
Complete amino acid sequence of the FK506 and Rapamycin binding protein, FKBP, isolated from calf thymus
Effects of Rapamycin, cyclosporin A, and dexamethasone on interleukin 5‐induced eosinophil degranulation and prolonged survival
Microbial conversion of Rapamycin
Therapeutic blood levels of sirolimus (Rapamycin) in the allografted rat
Effect of Rapamycin on the expression of the IL‐2 receptor (CD25)
Rapamycin inhibits transplant vasculopathy in long-surviving rat heart allografts.
β-Agonists regulate Na, K-ATPase via novel MAPK/ERK and Rapamycin-sensitive pathways
Assessment of cell‐signaling pathways in the regulation of mammalian target of Rapamycin (mTOR) by amino acids in rat adipocytes
Beneficial effects of cyclosporine and Rapamycin in small bowel ischemic injury
Routine clinical monitoring of sirolimus (Rapamycin) whole-blood concentrations by HPLC with ultraviolet detection
inhibition by Rapamycin of P‐glycoprotein 170‐mediated export from normal lymphocytes
Sample clean-up and high-performance liquid chromatographic techniques for measurement of whole blood Rapamycin concentrations
THE METABOLIC IMPACT OF Rapamycin (SIROLIMUS) IN CHRONIC CANINE ISLET GRAFT RECIPIENTS1
Rapamycin inhibits ribosomal protein synthesis and induces G1 prolongation in mitogen-activated T lymphocytes.
Dominant mutations confer resistance to the immunosuppressant, Rapamycin, in variants of a T cell lymphoma
Effects of cyclosporine and Rapamycin on immunoglobulin production by preactivated human B cells
Facile synthesis of the “tricarbonyl” subunit in the immunosuppressant Rapamycin
Effects of FK506 and Rapamycin on excitation‐contraction coupling in skeletal muscle fibres of the rat.
Involvement of a Rapamycin-sensitive pathway in CD40-mediated activation of murine B cells in vitro
Degradation of Rapamycin: synthesis of a Rapamycin derived fragment containing the tricarbonyl and triene sectors
Calcineurin inhibitor‐induced chronic nephrotoxicity in liver transplant patients is reversible using Rapamycin as the primary immunosuppressive agent
EFFECT OF TACROLIMUS (FK506) AND SIROLIMUS (Rapamycin) MONO-AND COMBINATION THERAPY IN PROLONGATION OF RENAL ALLOGRAFT …
Efficacy of Rapamycin and FK 506 in prolonging rat hind limb allograft survival.
Distinct repression of translation by wortmannin and Rapamycin
Evidence that Rapamycin inhibits interleukin-12-induced proliferation of activated T lymphocytes.
Determination of Rapamycin in whole blood by HPLC
Total synthesis of Rapamycin
Rapamycin inhibits p34cdc2 expression and arrests T lymphocyte proliferation at the G1/S transition.
Uncoupling p70s6 kinase activation and proliferation: Rapamycin-resistant proliferation of human CD8+ T lymphocytes
Exogenous shikimic acid stimulates Rapamycin biosynthesis inStreptomyces hygroscopicus
Ryanodine receptors from rabbit skeletal muscle are reversibly activated by Rapamycin
Synthetic studies toward Rapamycin: a solution to a problem in chirality merger through use of the Ireland reaction
The nature of the starter unit for the Rapamycin polyketide synthase
Invasive aspergillosis in mice immunosuppressed with cyclosporin A, tacrolimus (FK506), or sirolimus (Rapamycin)
Proinflammatory effects in experimental mesangial proliferative glomerulonephritis of the immunosuppressive agent SDZ RAD, a Rapamycin derivative
USE OF ANTI-CD25 MONOCLONAL ANTIBODY IN COMBINATION WITH Rapamycin TO ELIMINATE CYCLOSPORINE TREATMENT DURING THE INDUCTION …
Loss of ypk1 function causes Rapamycin sensitivity, inhibition of translation initiation and synthetic lethality in 14-3-3-deficient yeast
Acute effects of Rapamycin on glomerular dynamics: a micropuncture study in the rat
Cyclosporine, FK506, and Rapamycin. Some effects on early activation events in serum-free, mitogen-stimulated mouse spleen cells.
The cyclohexane moiety of Rapamycin is derived from shikimic acid in Streptomyces hygroscopicus
Murine recipients of fully mismatched donor marrow are protected from lethal graft-versus-host disease by the in vivo administration of Rapamycin but develop an …
In vitro and in situ absorption of SDZ-RAD using a human intestinal cell line (Caco-2) and a single pass perfusion model in rats: comparison with Rapamycin
Degradative studies on the tricarbonyl containing macrolide Rapamycin
The potential role of Rapamycin in pediatric transplantation as observed from adult studies
Comparison of the effects of FK-506, cyclosporin A and Rapamycin on IL-2 production.
Insulin-stimulated kinase from rat fat cells that phosphorylates initiation factor 4E-binding protein 1 on the Rapamycin-insensitive site (serine-111)
The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and Rapamycin.
Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells
Effect of Rapamycin on rat aortic ring vasomotion.
… cycle protein expression in vascular smooth muscle cells in vitro and in vivo is regulated through phosphatidylinositol 3-kinase and mammalian target of Rapamycin
Rapamycin blocks sexual development in fission yeast through inhibition of the cellular function of an FKBP12 homolog
Simultaneous on-line extraction and analysis of sirolimus (Rapamycin) and ciclosporin in blood by liquid chromatography–electrospray mass spectrometry
Both Rapamycin-sensitive and-insensitive pathways are involved in the phosphorylation of the initiation factor-4E-binding protein (4E-BP1) in response to insulin in rat …
Compared to mycophenolate mofetil, Rapamycin induces significant changes on growth factors and growth factor receptors in the early days postkidney …
Mammalian RAFT1 kinase domain provides Rapamycin-sensitive TOR function in yeast.
Conversion from liquid to solid Rapamycin formulations in stable renal allograft transplant recipients
Secretion of FK506/FK520 and Rapamycin by Streptomyces inhibits the growth of competing Saccharomyces cerevisiae and Cryptococcus neoformans
Side effects of Rapamycin in the rat
The effect of Rapamycin on single ENaC channel activity and phosphorylation in A6 cells
Rapamycin (Sirolimus) inhibits vascular smooth muscle DNA synthesis in vitro and suppresses narrowing in arterial allografts and in balloon-injured carotid arteries …
Measurement of Rapamycin in whole blood using reverse-phase high-performance liquid chromatography.
Regulation of the Rapamycin and FKBP-target 1/mammalian target of Rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase
Rapamycin stimulates viral protein synthesis and augments the shutoff of host protein synthesis upon picornavirus infection.
Two discrete regions of interleukin-2 (IL2) receptor β independently mediate IL2 activation of a PD98059/Rapamycin/wortmannin-insensitive Stat5a/b serine …
The tyrosine89 residue of yeast FKBP12 is required for Rapamycin binding
Assignment of the human FKBP12-Rapamycin-associated protein (FRAP) gene to chromosome 1p36 by fluorescence in situ hybridization
Rapamycin, but not FK506 and GPI-1046, increases neurite outgrowth in PC12 cells by inhibiting cell cycle progression
Rapamycin: personal algorithms for use based on 250 treated renal allograft recipients.
Rapamycin INHIBITS DEVELOPMENT OF OBLITERATIVE AIRWAY DISEASE IN A MURINE HETEROTOPIC AIRWAY TRANSPLANT MODEL1
The immunosuppressant Rapamycin blocks in vitro responses to hematopoietic cytokines and inhibits recovering but not steady-state hematopoiesis in vivo
Estrogen and Rapamycin effects on cell cycle progression in T47D breast cancer cells
The effects of the immunosuppressant Rapamycin on the growth of rheumatoid arthritis (RA) synovial fibroblast
Deletion of rapQONML from the Rapamycin gene cluster of Streptomyces hygroscopicus gives production of the 16-O-desmethyl-27-desmethoxy analog
Rapamycin may prevent post-transplant lymphoma
… π-face selectivity in anti aldol reactions of E-enol borinates from chiral alkoxymethyl ketones: stereocontrolled synthesis of a C24-C32 polyol subunit of Rapamycin
… of MAP kinases, pp90rsk and pp70‐S6 kinases in mouse mast cells by signaling through the c‐kit receptor tyrosine kinase or FcϵRI: Rapamycin inhibits activation of …
Intramolecular hydrogen transfer reactions of o-(bromophenyl) dialkylsilyl ethers. Preparation of Rapamycin-d1
… 3-kinase, protein kinase B, and p70 S6 kinases in lipopolysaccharide-stimulated Raw 264.7 cells: differential effects of Rapamycin, Ly294002, and wortmannin on …
Rapamycin dissociates p70S6K activation from DNA synthesis stimulated by bombesin and insulin in Swiss 3T3 cells
Rapamycin inhibits the phosphorylation of p70 S6 kinase in IL-2 and mitogen-activated human T cells
Rapamycin: immunosuppression, hyporesponsiveness, and side effects in a porcine renal allograft model.
Effect of cyclosporine, mycophenolic acid, and Rapamycin on the proliferation of rat aortic vascular smooth muscle cells: in vitro study
Single-channel activity of the Ca2+-dependent K+ channel is modulated by FK506 and Rapamycin
Use of Rapamycin for the suppression of alloimmune reactions in vivo: schedule dependence, tolerance induction, synergy with cyclosporine and FK 506, and effect on …
Failure of Rapamycin to block proliferation once resting cells have entered the cell cycle despite inactivation of p70 S6 kinase
Rapamycin inhibits proteasome activator expression and proteasome activity
ASSOCIATION OF GLUCOCORTICOIDS AND CYCLOSPORIN A OR Rapamycin PREVENTS E-SELECTIN AND IL-8 EXPRESSION DURING LPS-AND TNFα …
The zinc finger protein GLI induces cellular sensitivity to the mTOR inhibitor Rapamycin
Sirolimus (Rapamycin) in clinical transplantation
Rapamycin inhibits didemnin B‐induced apoptosis in human HL‐60 cells: Evidence for the possible involvement of FK506‐binding protein 25
Siloxanes: versatile templates for acyclic stereocontrol. Synthesis of the C27-C33 segment of Rapamycin
Dose-dependent pharmacokinetics of Rapamycin-28-N,N-dimethylglycinate in the mouse
Interstitial pneumonitis associated with sirolimus (Rapamycin) therapy after liver transplantation
The relationship of blood concentrations of Rapamycin and cyclosporine to suppression of allograft rejection in a rabbit heterotopic heart transplant model.
… -severe combined immunodeficient (HuPBL-SCID) mouse/skin allograft model is T cell mediated and inhibited by a combination of cyclosporine and Rapamycin
… hydration contributions to the thermodynamics of ligand binding by proteins. Enthalpy and heat capacity changes of tacrolimus and Rapamycin binding to FK506 …
Selective epimerization of Rapamycin via a retroaldol/aldol mechanism mediated by titanium tetraisopropoxide
inhibition of proliferation but not erythroid differentiation of J2E cells by Rapamycin
The 14-3-3 proteins positively regulate Rapamycin-sensitive signaling
Systemic toxicity following administration of sirolimus (formerly Rapamycin) for psoriasis: association of capillary leak syndrome with apoptosis of lesional lymphocytes
Oral administration of Rapamycin and cyclosporine differentially alter intestinal function in rabbits
p70 S6 kinase sensitivity to Rapamycin is eliminated by amino acid substitution of Thr229.
High‐Sensitivity sequencing of large proteins: Partial structure of the Rapamycin‐fkbp12 target
Renal effects of Rapamycin in the spontaneously hypertensive rat
Effects of immunosuppressants FK506 and Rapamycin on the heterooligomeric form of the progesterone receptor
Sirolimus (Rapamycin, Rapamune®) and combination therapy with cyclosporin A in the rat developing adjuvant arthritis model: correlation with blood levels and the …
The effect of Rapamycin on renal function in the rat: a comparative study with cyclosporine
Efficient Removal of Pipecolinate from Rapamycin and FK506 by Reaction with n-Bu4N+ CN−
Rapamycin resistance in ataxia-telangiectasia.
Regulation of ribosomal S6 kinase 2 by mammalian target of Rapamycin
Induction of differentiation of human myeloid leukemia cells by immunosuppressant macrolides (Rapamycin and FK506) and calcium/calmodulin-dependent kinase …
Lipophilic benzamide and anilide derivatives as high-performance liquid chromatography internal standards: application to sirolimus (Rapamycin) determination
Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with Rapamycin
… by insulin and insulin-like growth factor-I: glycogen synthase activation is antagonized by wortmannin or LY294002 but not by Rapamycin or by inhibiting …
Pharmacokinetics of Rapamycin: single-dose studies in the rabbit.
Preferential production of Rapamycin vs prolylRapamycin by Streptomyces hygroscopicus
Successful myoblast allotransplantation in mdx mice using Rapamycin
A second type-I PKS gene cluster isolated from Streptomyces hygroscopicus ATCC 29253, a Rapamycin-producing strain
Pediatric utilization of Rapamycin for severe cardiac allograft rejection
An application of the suárez reaction to the regiospecific and stereospecific synthesis of the C28-C42 segment of Rapamycin
Immunopharmacology of Rapamycin
Manipulation of the Rapamycin effector domain. selective nucleophilic substitution of the C7 methoxy group
High performance liquid chromatographic isolation, spectroscopic characterization, and immunosuppressive activities of two Rapamycin degradation products
Antifungal Rapamycin analogues with reduced immunosuppressive activity
… localization of the human α4/IGBP1 gene, the structure of which is closely related to the yeast TAP42 protein of the Rapamycin-sensitive signal transduction pathway
Antagonistic roles for CTLA-4 and the mammalian target of Rapamycin in the regulation of clonal anergy: enhanced cell cycle progression promotes recall antigen …
inhibition by Rapamycin of ornithine decarboxylase and epithelial cell proliferation in intestinal IEC‐6 cells in culture
Insulin stimulation of muscle protein synthesis in obese Zucker rats is not via a Rapamycin-sensitive pathway
Stability of sirolimus (Rapamycin) in whole blood
Automated simultaneous quantification of the immunosuppressants 40-O-(2-hydroxyethyl)Rapamycin and cyclosporine in blood with electrospray-mass spectrometric …
Cytokine and alloantibody networks in long term cardiac allografts in rat recipients treated with Rapamycin.
FK506 and Rapamycin modulate the functional activities of human peripheral blood eosinophils
Sirolimus (Rapamycin) potentiates cyclosporine in prevention of acute lung rejection
Rapamycin potentiates dexamethasone-induced apoptosis and inhibits JNK activity in lymphoblastoid cells
FAP1, a homologue of human transcription factor NF‐X1, competes with Rapamycin for binding to FKBP12 in yeast
Rapamycin destabilizes interleukin-3 mRNA in autocrine tumor cells by a mechanism requiring an intact 3’untranslated region.
Effect of Rapamycin on morphological and functional parameters in the kidney of the rabbit
Synthetic investigations of Rapamycin. 1. Synthesis of a C10-C21 fragment
Suppression of acute rejection in allogeneic rat lung transplantation: a study of the efficacy and pharmacokinetics of Rapamycin derivative (SDZ RAD) used alone and …
Proton and nitrogen sequential assignments and secondary structure determination of the human FK506 and Rapamycin binding protein
Abrogation by Rapamycin of accelerated rejection in sensitized rats by inhibition of alloantibody responses and selective suppression of intragraft mononuclear and …
FK506 binding protein 12 mediates sensitivity to both FK506 and Rapamycin in murine mast cells
Post-translational reduction of cell surface expression of insulin receptors by cyclosporin A, FK506 and Rapamycin in bovine adrenal chromaffin cells
Antiproliferative effect of Rapamycin on growth factor-stimulated human adult lung fibroblasts in vitro may explain its superior efficacy for prevention and treatment of …
Effects of the combination of Rapamycin with tacrolimus or cyclosporin on experimental intimal hyperplasia
Anisomycin and Rapamycin define an area upstream of p70/85S6k containing a bifurcation to histone H3-HMG-like protein phosphorylation and c-fos-c-jun induction.
Rapamycin inhibits production of cytotoxic but not noncytotoxic antibodies and preferentially activates T helper 2 cells that mediate long-term survival of heart …
Studies towards the total synthesis of Rapamycin: Preparation of the C10 C17 carbon unit
Effects of Rapamycin on apoptosis of rheumatoid synovial cells
Rapamycin and T cell costimulatory blockade as post-transplant treatment promote fully MHC-mismatched allogeneic bone marrow engraftment under …
Mean field analysis of FKBP12 complexes with FK506 and Rapamycin: Implications for a role of crystallographic water molecules in molecular recognition and …
Effects of immunosuppressive peptidyl-prolyl cis-trans isomerase (PPIase) inhibitors, cyclosporin A, FK506, ascomycin and Rapamycin, on hair growth initiation in …
High performance liquid chromatographic isolation and spectroscopic characterization of three major metabolites from the plasma of rats receiving Rapamycin …
Implication of alpha4 phosphoprotein and the Rapamycin-sensitive mammalian target-of-Rapamycin pathway in prolactin receptor signalling
Effects of Rapamycin on human HLA-unrestricted cell killing
cDNA Cloning of a human 5 kDa FK506 and Rapamycin binding protein
Identification of a new metabolite of macrolide immunosuppressant, like Rapamycin and SDZ RAD, using high performance liquid chromatography and electrospray …
Evidence that Rapamycin has differential effects of IL-4 function. Multiple IL-4 signaling pathways and implications for in vivo use.
Calcium/calmodulin kinase inhibitors and immunosuppressant macrolides Rapamycin and FK506 inhibit progestin-and glucocorticosteroid receptor-mediated …
CsA, FK506, corticosteroids and Rapamycin inhibit TNFα production by cultured PTEC
Augmentation of SR Ca2+ release by Rapamycin and FK506 causes K+‐channel activation and membrane hyperpolarization in bladder smooth muscle
Dihydroxylation of the triene subunit of Rapamycin
Rituximab and Rapamycin for posttransplant lymphoproliferative disease treatment: report of three cases
Effect of single-dose Rapamycin-based immunosuppression on the development of cardiac allograft vasculopathy.
Rapamycin, FK506 and cyclosporin A inhibit human prolactin gene expression
The immunomodulatory drugs cyclosporin A, mycophenolate mofetil, and sirolimus (Rapamycin) inhibit allergen-induced proliferation and IL-5 production by PBMCs …
Rapamycin selectively blocks interleukin-2-induced proliferating cell nuclear antigen gene expression in T lymphocyte: evidence for inhibition of CREB/ATF …
Rapamycin treatment depresses intragraft expression of KC/MIP-2, granzyme B, and IFN-gamma in rat recipients of cardiac allografts.
Reversal of ongoing heart, kidney, and pancreas allograft rejection and suppression of accelerated heart allograft rejection in the rat by Rapamycin.
Glucocorticoid-induced insulin resistance of protein synthesis is independent of the Rapamycin-sensitive pathways in rat skeletal muscle
Long-term in vivo effects of Rapamycin on humoral and cellular immune responses in the rat
… signals that control cell proliferation in mammalian balance epithelia: key roles for phosphatidylinositol-3 kinase, mammalian target of Rapamycin, and S6 kinases in …
Rapamycin, a potent inhibitor of T-cell function, prevents graft rejection in murine recipients of allogeneic T-cell-depleted donor marrow [published erratum appears in …
Immunosuppressant Rapamycin inhibits protein kinase C α and p38 mitogen-activated protein kinase leading to the inhibition of chondrogenesis
FK506 and Rapamycin selectively enhance degradation of IL-2 and GM-CSF mRNA.
THE IMMUNOSUPPRESSIVE EFFECT OF Rapamycin ON MOUSE SMALL BOWEL TRANSPLANTATION1
Studies on selective reductions of Rapamycin
Rapamycin: biological and therapeutic effects, binding by immunophilins and molecular targets of action
PHARMACOKINETICS AND TOLERABILITY OF 40–0-[2-HYDROXYETHYL] Rapamycin IN DE NOVO LIVER TRANSPLANT RECIPIENTS1
The synergistic interactions in vitro and in vivo of brequinar sodium with cyclosporine or Rapamycin alone and in triple combination.
The future role of target of Rapamycin inhibitors in renal transplantation
Rapamycin-induced long-term allograft survival depends on persistence of alloantigen.
Effects of Rapamycin on renal hemodynamics, water and sodium excretion, and plasma levels of angiotensin II, aldosterone, atrial natriuretic peptide, and vasopressin …
Structural identification of three metabolites and a degradation product of the macrolide immunosuppressant sirolimus (Rapamycin) by electrospray-MS/MS after …
Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant Rapamycin.
Comparison of the effect of Rapamycin and FK506 on release of prostacyclin and endothelin in vitro
A nonimmunosuppressive triene-modified Rapamycin analog is a potent inhibitor of peptidyl prolyl cis-trans-isomerase
Cleavage of the cyclohexyl-subunit of Rapamycin results in loss of immunosuppressive activity
A high performance liquid chromatographic method for the determination of Rapamycin (sirolimus) in rat serum, plasma, and blood and in monkey serum
Cyclosporin A, FK506, Rapamycin: the use of a quantitative analytic tool to discriminate immunosuppressive drug interactions.
Quantitative comparison of Rapamycin and cyclosporine effects on cytokine gene expression studied by reverse transcriptase-competitive polymerase chain reaction.
Methionine Interference in Rapamycin Production Involves Repression of DemethylRapamycin Methyltransferase andS-Adenosylmethionine Synthetase
A highly convergent strategy towards Rapamycin. Stereoselective construction of the C 8–C 18 fragment
FK506 and Rapamycin binding to FKBP: Common elements in immunophilin-ligand complexation
Cloning and sequence analysis of a Rapamycin-binding protein-encoding gene (RBP1) from Candida albicans
Functional and histopathologic effects of Rapamycin on mouse kidney
Reversal of multidrug resistance in Chinese hamster ovary cells by the immunosuppressive agent Rapamycin
Structural basis for peptidomimicry by the effector element of Rapamycin
Involvement of the Rapamycin-sensitive pathway in the insulin regulation of muscle protein synthesis in streptozotocin-diabetic rats
COADMINISTRATION OF NEORAL AND THE NOVEL Rapamycin ANALOG, SDZ RAD, TO RAT LUNG ALLOGRAFT RECIPIENTS: Potentiation of …
Efficacies of sirolimus (Rapamycin) and cyclosporine in allograft vascular disease in non-human primates: trough levels of sirolimus correlate with inhibition of …
ADJUNCTIVE Rapamycin AND CsA TREATMENT INHIBITS MONOCYTE/MACROPHAGE ASSOCIATED CYTOKINES/CHEMOKINES IN SENSITIZED CARDIAC …
Rapamycin (sirolimus) inhibits heart cell growth in vitro
Rapamycin‐resistant phosphorylation of the initiation factor‐4E‐binding protein (4E‐BP1) in v‐SRC‐transformed hamster fibroblasts
Acid catalyzed functionalization of Rapamycin
Discordant effects of Rapamycin on proliferation and p70S6 kinase phosphorylation in normal and neoplastic rat chromaffin cells
Missense mutations at the FKBP12-Rapamycin-binding site of TOR1
Nutritional and intestinal effects of the novel immunosuppressive agents: deoxyspergualin, Rapamycin, and mycophenolate mofetil
Rapamycin inhibits protein kinase C activity and stimulates Na+ transport in A6 cells
inhibition by Rapamycin of leukocyte migration and bronchial hyperreactivity induced by injection of Sephadex beads to guinea‐pigs
The RB/p107/p130 phosphorylation pathway is not inhibited in Rapamycin-induced G1-prolongation of NIH3T3 cells.
The mechanism of unresponsiveness to allografts induced by Rapamycin and Rapamycin/cyclosporine treatment in rats.
Calorimetric measurements of the complexation of cyclosporin A, ascomycin, fujimycin, and Rapamycin with lithium chloride and with an immunophilin
ANALYSIS OF FUNCTIONAL RENAL ALLOGRAFT TOLERANCE WITH SINGLE-DOSE Rapamycin BASED INDUCTION IMMUNOSUPPRESSION1
Genetic relationships among actinomycetes that produce the immunosuppressant macrolides FK506, FK520/FK523 and Rapamycin
Rapamycin inhibits IL-1-mediated interferon-gamma production in the YAC-1 T cell lymphoma
Rapamycin inhibits airway leukocyte infiltration and hyperreactivity in guinea pigs
Synthetic approaches to Rapamycin
Synthesis of the Tricarbonyl Subunit (C8−C19) of Rapamycin via Tandem Chan Rearrangement−Oxidation
Rapamycin synthetic studies. 2. Elaboration of the C (10)-C (26) perimeter
Use of Rapamycin in a transplant patient who developed cyclosporin neurotoxicity
Prolactin and insulin synergize to regulate the translation modulator PHAS-I via mitogen-activated protein kinase-independent but wortmannin-and Rapamycin …
Manipulation of the C (22)-C (27) region of Rapamycin: stability issues and biological implications
Opposing effects of Rapamycin and cyclosporin A on activation-induced Ca2+ release
Detection of noncovalent FKBP-FK506 and FKBP-Rapamycin complexes by capillary electrophoresis-mass spectrometry and capillary electrophoresis-tandem mass …
Comparative effects of Rapamycin FK 506 and cyclosporine on antibody production, lymphocyte populations and immunoglobulin isotype switching in the rat
Rapamycin insensitivity in Schistosoma mansoni is not due to FKBP12 functionality
Lipase mediated hydrolysis of Rapamycin 42-hemisuccinate benzyl and methyl esters
The effect of the immunophilin ligands Rapamycin and FK506 on proliferation of mast cells and other hematopoietic cell lines.
Rapamycin: A new and highly active immunosuppressive macrolide with an efficacy superior to cyclosporine
Effect of a short course of Rapamycin, cyclosporin A, and donor-specific transfusion on rat cardiac allograft survival.
Cyclosporin A, FK506 and Rapamycin produce multiple, temporally distinct, effects on memory following single-trial, passive avoidance training in the chick
Effect of Rapamycin on renal allograft survival in canine recipients treated with antilymphocyte serum, donor bone marrow, and cyclosporine.
Synthesis of I‐125 labeled photoaffinity Rapamycin analogs
Interleukin 4-inducible phosphorylation of HMG-I (Y) is inhibited by Rapamycin
inhibition of CTL induction by Rapamycin: IL-2 rescues granzyme B and perforin expression but only partially restores cytotoxic activity.
Effects of cyclosporin A, Rapamycin, and FK520 on peripheral T-cell deletion and anergy
The effect of cyclosporin A, FK506 and Rapamycin on the murine contact sensitivity reaction
Structure of FKBP12. 6 in complex with Rapamycin
SUPERIORITY OF SIROLIMUS (Rapamycin) OVER CYCLOSPORINE IN AUGMENTING ALLOGRAFT AND XENOGRAFT SURVIVAL IN MICE TREATED WITH …
Rapamycin but not FK506 inhibits the proliferation of mononuclear phagocytes induced by colony-stimulating factors
inhibition of host-versus-graft and graft-versus-host responses after small bowel transplantation in rats by Rapamycin.
Rapamycin and FK506 differentially inhibit mast cell cytokine production and cytokine-induced proliferation and act as reciprocal antagonists.
DETERMINATION OF AN IMPROVED SIROLIMUS (Rapamycin)-BASED REGIMEN FOR INDUCTION OF ALLOGRAFT TOLERANCE IN MICE TREATED WITH …
Structure of the human 25 kDa FK506 binding protein complexed with Rapamycin
The effects of Rapamycin on humoral immunity in vivo. Suppression of primary responses but not of ongoing alloantibody synthesis or memory responses.
Hypersensitivity to Rapamycin of BJAB B lymphoblastoid cells.
… IMMUNOMODULATION LEADS TO ENHANCED ALLOGRAFT SURVIVAL IN COMBINATION WITH CYCLOSPORINE A AND Rapamycin, BUT NOT FK5061
The effect of Rapamycin on c-jun expression in human lymphocytes
Tritium labelling of RAD001—a new Rapamycin derivative
Relationship between multiple biologic effects of Rapamycin and the inhibition of pp70S6 protein kinase activity. Analysis in mutant clones of a T cell lymphoma.
In vivo inhibition of cytokine responsiveness and graft-versus-host disease mortality by Rapamycin leads to a clinical-pathological syndrome discrete from that …
Rapamycin Prolongs Survival of Murine Recipients of Fully Allogeneic Donor Grafts When Administered during the Graft‐versus‐Host Disease Process a
Isolation and identification of new Rapamycin dihydrodiol metabolites from dexamethasoneinduced rat liver microsomes
Rapamycin and FK506 induce long-term potentiation by pairing stimulation via an intracellular Ca2+ signaling mechanism in rat hippocampal CA1 neurons
… triamcinolone acetonide accumulation in mouse fibroblasts is differently modulated by the immunosuppressants cyclosporin A, FK506, Rapamycin and their analogues …
… C/EBP homologous protein (CHOP) by amino acid deprivation requires insulin-like growth factor I, phosphatidylinositol 3-kinase, and mammalian target of Rapamycin …
Insulin regulation of insulin-like growth factor-binding protein-1 gene expression is dependent on the mammalian target of Rapamycin, but independent of …
Conformational changes of Rapamycin and analogs upon complexing with FKBP associated with activity: an application of second derivative CD spectroscopy
inhibition of S6 Kinase by Rapamycin Blocks Maturation ofRana dybowskiiOocytes
Reversible isomerization of Rapamycin demonstrated by liquid chromatography
The human gene encoding FKBP-Rapamycin associated protein (FRAP) maps to chromosomal band 1p36. 2
Studies towards the total synthesis of Rapamycin: Preparation of the cyclohexyl C33 C42 fragment and further coupling to afford the C22 C42 carbon unit
The effect of anti‐IL‐4 monoclonal antibody, Rapamycin and interferon‐γ on airway hyperreactivity to acetylcholine in mice
IL-2 induces beta2-integrin adhesion via a wortmannin/LY294002-sensitive, Rapamycin-resistant pathway. Phosphorylation of a 125-kilodalton protein correlates with …
Biochemical and structural studies of the FK506-and Rapamycin-binding proteins (FKBPs).
Rapamycin-sensitive phosphorylation of ribosomal protein S17 by p70 S6 kinase
Differential inhibition of cutaneous T-cell-mediated reactions and epidermal cell proliferation by cyclosporin A, FK-506, and Rapamycin
Cyclosporine and Rapamycin affect protein kinase C induction of the intracellular activation signal, activator of DNA replication.
The effect of cyclosporin A, FK506, and Rapamycin on the murine chronic graft‐versus‐host response—an in vivo model of Th2‐like activity
Efficacy of Rapamycin, RS-61443 and cyclophosphamide in the prolongation of survival of discordant pig to rabbit cardiac xenografts.
Rapamycin graft pretreatment in small bowel and kidney transplantation in the rat.
Left main Rapamycin-coated stent: Invasive versus noninvasive angiographic follow-up
Investigation of Rapamycin transport and uptake across absorptive human intestinal cell monolayers
Effects of wortmannin and Rapamycin on CSF-1-mediated responses in macrophages
Cyclosporin A, Rapamycin and FK506 decrease prolactin release from rat pituitary cells in primary culture
Sirolimus: mammalian target of Rapamycin inhibitor to prevent kidney rejection
Hepatotrophic properties in dogs of human FKBP, the binding protein for FK506 and Rapamycin
Up-regulation of cell surface sodium channels by cyclosporin A, FK506, and Rapamycin in adrenal chromaffin cells
Synergistic effect of Rapamycin and cyclosporine in prevention of acute kidney allograft rejection in the mouse
Isolation of a human cDNA encoding a 25 kDa FK-506 and Rapamycin binding protein
Suppression of allograft responses by combining alloantigen-specific iv pre-sensitization with suboptimal doses of Rapamycin
Rapamycin
Comparison of binding characteristics of four Rapamycin metabolites to the 14 and 52 kDa immunophilins with their pharmacologic activity measured by the mixed …
Hemolytic uremic syndrome after renal transplantation: immunosuppressive therapy with Rapamycin
Immunosuppressants FK506 and Rapamycin have different effects on the biosynthesis of cytoplasmic actin during the early period of T cell activation
Inducible membrane recruitment of small GTP-binding proteins by Rapamycin-based system in living cells
Intragraft cytokine expressionf in tolerant rat renal allografts with Rapamycin and cyclosporin immunosuppression
Evidence that Rapamycin rescue therapy delays rejection of major (MHC) plus minor (non-MHC) histoincompatible heart allografts in rats.
Ethanol potentiates the stimulatory effects of insulin and phosphocholine on mitogenesis by a zinc-dependent and Rapamycin-sensitive mechanism in fibroblasts and …
… CD8+ T cells tolerized in vivo: employing a model of Ld-specific TCR transgenic mice transplanted with allogenic hearts under the cover of a short-term Rapamycin …
Insulin regulation of hepatic insulin-like growth factor-binding protein-1 (IGFBP-1) gene expression and mammalian target of Rapamycin (mTOR) signalling is impaired …
Saccharomyces cerevisiae contains a homolog of human fkbp‐13, a membrane‐associated fk506/Rapamycin binding protein
An unexpected inhibitory effect of Rapamycin against germination of spores of Bacillus brevis strain Nagano
Identification of a 14 kDa FK-506/Rapamycin binding immunophilin from calf thymus
… –electrospray mass spectrometric assay for the specific and sensitive quantification of the novel immunosuppressive macrolide 40-O-(2-hydroxyethyl) Rapamycin
Rapamycin inhibits activation of ryanodine receptors from skeletal muscle by the fatty acyl CoA–acyl CoA binding protein complex
Exclusion of the 13-kDa Rapamycin binding protein gene (FKBP2) as a candidate gene for multiple endocrine neoplasia type 1
Towards the synthesis of the C37-C42 fragment of Rapamycin: intramolecular reactions of allyl silanes with oxonium ions generated from α-alkoxy sulfones.
Quantitative and temporal analysis of the cellular interaction of FK-506 and Rapamycin in T-lymphocytes.
… ARE NOT REQUIRED FOR INDUCTION OF ALLOGRAFT TOLERANCE IN MICE TREATED WITH ANTILYMPHOCYTE SERUM, Rapamycin, AND DONOR BONE …
A comparison of the effects of Rapamycin and cyclosporine on kidney and heart morphology in a rabbit heterotopic heart transplant model
Murine TRAIL (TNF-related apoptosis inducing ligand) expression induced by T cell activation is blocked by Rapamycin, cyclosporin A, and inhibitors of …
Cyclosporine, FK-506, Rapamycin, and other immunomodulators
Rapamycin INDUCES TGF-β PRODUCTION IN LYMPOCYTES
Marked prolongation of rat skin xenografts induced by intrathymic injection of xenogeneic splenocytes and a short course of Rapamycin in antilymphocyte serum …
inhibition of cellular transfer of experimental autoimmune uveoretinitis by Rapamycin
Rapamycin: a future in cancer treatment?
Reduction of Sephadex-induced lung inflammation and bronchial hyperreactivity by Rapamycin.
K+ currents responsible for repolarization in mouse ventricle and their modulation by FK-506 and Rapamycin
14-3-3τ associates with a translational control factor FKBP12-Rapamycin-associated protein in T-cells after stimulation by pervanadate
IL-2-dependent induction of G1 cyclins in primary T cells is not blocked by Rapamycin or cyclosporin A
Evidence that FK506 and Rapamycin block T cell activation at different sites relative to early reversible phosphorylation involving the protein phosphatases PP1 and …
Partial characterization of a 52 kDa CsA/FK506/Rapamycin binding protein
Rapamycin: Therapeutic range investigations
Brief treatment with Rapamycin in vivo increases responsiveness to alloantigens measured by the mixed lymphocyte response
Anti-CD2 monoclonal antibodies synergize with FK506 but not with cyclosporine or Rapamycin to induce tolerance.
Up-regulation of insulin-like growth factor binding protein-5 is independent of muscle cell differentiation, sensitive to Rapamycin, but insensitive to wortmannin and …
The effect of cyclosporine, Rapamycin and FK 506 the survival following allogeneic bone marrow transplantation
Treatment of normal skeletal muscle with FK506 or Rapamycin results in halothane-induced muscle contracture
EFFECT OF IN VIVO Rapamycin TREATMENT ON DE NOVO T-CELL DEVELOPMENT IN RELATION TO INDUCTION OF AUTOIMMUNE-LIKE …
Swinging the vote for Rapamycin
Activation of 70‐kDa S6 kinase, induced by the cytokines interleukin‐3 and erythropoietin and inhibited by Rapamycin, is not an absolute requirement for cell …
Rapamycin increases transforming growth factor-β mRNA expression in immortalized rat proximal renal tubular cells
Divergent effects of Rapamycin on mouse and rat cells following mitogenic stimulation
Differential effects of the immunosuppressive macrolides FK-506 and Rapamycin on activation-induced T-cell apoptosis
Induction of tolerance to skin allografts by intrathymic injection of donor splenocytes. Effect of donor-recipient strain combination and supplemental Rapamycin.
Isolation and identification of a C39 demethylated metabolite of Rapamycin from pig liver microsomes and evaluation of its immunosuppressive activity
… from pig liver microsomes, identification by electrospray tandem mass spectrometry and in vitro immunosuppressive activity of a Rapamycin tris‐epoxide metabolite
Ionization of the c7 methoxy group in Rapamycin by 5 M lithium perchlorate-diethyl ether
Induction of CD5 on B and T cells is suppressed by cyclosporin A, FK-520 and Rapamycin
Mammalian target of Rapamycin: Immunosuppressive drugs offer new insights into cell growth regulation
Rapamycin-induced apoptosis is p53-independent in human prostate carcinoma PC-3 cells
Probing T-cell signal transduction pathways with the immunosuppressive drugs, FK-506 and Rapamycin
Stereoselective construction of the C 21–C 42 fragment of Rapamycin
Rapamycin FOR REFRACTORY RENAL ALLOGRAFT REJECTION.
C‐14 labelling of NVP RAD001—a new Rapamycin derivative
The immunosuppressive macrolides FK-506 and Rapamycin
Inhibitors of mammalian target of Rapamycin
inhibition of the Mr 70,000 S6 kinase pathway by Rapamycin results in chromosome malsegregation in yeast and mammalian cells
Possible involvement of Rapamycin-sensitive pathway in Bcl-2 expression in human neuroblastoma SH-SY5Y cells
Ionizing radiation enhances double-strand-break repair in Rapamycin-treated ataxia telangiectasia lymphoblasts
Effect of Rapamycin on prolactin-stimulated S6 kinase activity and milk product formation in mouse mammary explants
Differential effect of Rapamycin and cyclosporin A in proliferation in a murine T cell line expressing either intermediate or high affinity receptor for IL-2
A short-term combination therapy with cyclosporine and Rapamycin or leflunomide induces long-term heart allograft survival in a strongly immunogenic strain …
FK-506 and Rapamycin but not cyclosporin inhibit aldosterone-stimulated sodium transport in A6 cells
FK506 and Rapamycin: Differential sensitivity of human, baboon, cynomolgus monkey, dog and pig lymphocytes
Late adjunctive therapy with single doses of Rapamycin in skin-allografted mice treated with antilymphocyte serum and donor bone marrow cells
Rapamycin inhibits substance P-induced protein synthesis and phosphorylation of PHAS-I (4E-BP1) and p70 S6 kinase (p70 (S6K)) in human astrocytoma cells
… peptide corresponding to residues 65–79 of an HLA class II sequence: functional similarities but mechanistic differences with the immunosuppressive drug Rapamycin
Synthesis and bioactivity of photolabile sirolimus (Rapamycin) analogs
Rapamycin for GVHD prophylaxis-potential for severe myelotoxicity
Provocative effects of the immunosuppressants Rapamycin, tacrolimus, and dexamethasone on Pneumocystis carinii pneumonitis in contrast to the anti-Pneumocystis …
Comparative effects of FK-506, Rapamycin and cyclosporin A, on the in vitro differentiation of dorsal root ganglia explants and septal cholinergic neurons
Anti‐CD28 antibody‐and IL‐4‐induced human T cell proliferation is sensitive to Rapamycin
Rapamycin inhibits aldolase A expression during human lymphocyte activation
The effects of FK 506, cyclosporine, and Rapamycin on liver growth in vitro and in vivo
Analogous conformations of both binding and effector regions in cyclosporin A, FK506 and Rapamycin
X-ray Crystal Structure of 28-O-MethylRapamycin complexed with FKBP12: Is the Cyclohexyl Moiety Part of the Effector Domain of Rapamycin?
Rapamycin, cyclosporine, and perioperative donor-specific transfusions induce prolongation of cardiac allograft survival in the rat.
Structure-activity relationships involving modifications to the macrolides FK-506 and Rapamycin
Comparative study of CSA and FK506 versus newer immunosuppressive drugs MMF and Rapamycin on coronary endothelial function in vitro
PHAS-I phosphorylation in response to foetal bovine serum (FBS) is regulated by an ERK1/ERK2-independent and Rapamycin-sensitive pathway in 3T3-L1 …
Structural analysis of Rapamycin and related compounds using [M + Li]+ ions generated by liquid secondary ion mass spectrometry
The gene structure and promoter analysis of mouse lymphocyte signal transduction molecule α4 that is related to the yeast TAP42 involved in a Rapamycin-sensitive …
The transcriptional profile of Saccharomyces cerevisiae exposed to Rapamycin mimics the profile induced by amino acid starvation
… with chiral homoallylic ethers: An application to the asymmetric synthesis od (11R, 14S)-anti-and (31R, 34S)-syn-segements of immunosuppressant Rapamycin
SAFETY AND PHARMACOKINETIC PROFILE OF ASCENDING SINGLE DOSES OF ORAL LIQUID SIROLIMUS (Rapamycin) IN PEDIATRIC PATIENTS WITH STABLE …
… suppression of T cell responses to minor histocompatibility antigens by chloroquine in combination with tacrolimus and a Rapamycin derivative, SDZ-RAD
… factor β1 inhibits interleukin‐1‐induced but enhances ionomycin‐induced interferon‐γ production in at cell lymphoma: Comparison with the effects of Rapamycin
Long-term viability of articular cartilage after microsurgical whole-joint transplantation and immunosuppression with Rapamycin, mycophenolate mofetil, and tacrolimus
Effect of cyclosporin A, Rapamycin, and FK-506 on corneal epithelial cells and lymphocyte proliferation
Comparative in vitro studies on the immunosuppressive activities of mycophenolic acid, bredinin, FK 506, cyclosporine, and Rapamycin
Responsiveness of preactivated B cells to IL-2 and IL-6. Effect of cyclosporine and Rapamycin.
Differential effects of cyclosporin-A and Rapamycin on in vivo thymocyte maturation
Immunopharmacology of Rapamycin (A review)
Synergism between corticosteroids and Rapamycin for the treatment of intraocular inflammation
Rapamycin induces binding activity to the terminal oligopyrimidine tract of ribosomal protein mRNA in rats
Intrasplenic liver parenchymal cells in conjunction with low-dose Rapamycin and cyclosporine induce a unique and specific prolongation of rat cardiac and small bowel …
Target of Rapamycin (TOR) signaling coordinates tRNA and 5S rRNA gene transcription with growth rate in yeast
HPLC Analysis of Rapamycin
TGF-beta Provides the Rationale for the Synergistic Immunpsuppression with Rapamycin (RAPA), Cyclosporine (CsA) and Tacrolimus (TAC)
Pharmacokinetic and pharmacodynamic correlations of cyclosporine (CsA) and Rapamycin (RAPA) in 120 patients treated for at least 2 years at a single center.
Effects of mycophenolic acid, Rapamycin, and carvedilol on the PDGF-induced fibronectin secretion by rat vascular smooth muscle cells: Implication of MAP kinase
The Effect of Immunosuppressive Agents (FK‐506, Rapamycin) on Renal P450 Systems in Rat Models
A comparison of in vivo responses to cyclosporine, FK506, and Rapamycin following allogeneic immune challenge
Rapamycin inhibits the in vitro release of soluble CD23 by SAC/IL-2/IL-4-activated human peripheral blood B lymphocytes
Comparison of FK‐506, Rapamycin, Ascomycin, and Cyclosporine in Mouse Models of Host‐versus‐Graft Disease and Heterotopic Heart Transplantation
Generation and evaluation of putative neuroregenerative drugs: Part 2: Screening virtual libraries of novel polyketides which possess the binding domain of Rapamycin
Steroids, Rapamycin, and breast cancer cells.
ADDITION OF Rapamycin TO CYCLOSPORINE-PREDNISONE BASED IMMUNOSUPPRESSION REDUCES THE CLINICAL RISK OF PRETRANSPLANT ANTI …
Rapamycin treatment depresses
Osmotic pump delivery of Rapamycin
An open-label multi-center clinical study of the efficacy and safety of Rapamycin in combination with CsA and steroid to prevent the acute rejection of kidney …
inhibition of anti-CD3 antibody-induced mouse T cell activation by pentoxifylline in combination with Rapamycin or A77 1726 (leflunomide)
Prevention of cardiac allograft rejection by FK506 and Rapamycin: assessment by histology and nuclear magnetic resonance
Induction of IL-5 expression by IL-2 is resistant to the immunosuppressive agents cyclosporin A and Rapamycin.
Rapamycin inhibits the in vitro release of soluble interleukin-2 receptor by activated peripheral blood mononuclear cells (PBMC) independently of the mode of …
Rapamycin (Sirolimus) reduces luminal narrowing after balloon angioplasty in porcine coronary arteries
The Rapamycin sensitivity of human T-cell leukaemia virus type I-induced T-cell proliferation is mediated independently of the polypyrimidine motifs in the 5′ long …
Signaling Pathways for Translation: Stress, Calcium, and Rapamycin
Rapamycin and reduced dose cyclosporin produce effective immunosuppression for de novo renal transplant recipients
Differentiation by Rapamycin
Generation and evaluation of putative neuroregenerative drugs: Part 1: virtual point mutations to the polyketide Rapamycin
Triglyceride (TG) elevations in renal transplant recipients treated with sirolimus (Rapamycin, RAPA) added to a cyclosporine (CsA)/prednisone (pred) regimen
Rapamycin: a new immunosuppressive agent capable of inhibiting chronic rejection?
Effects of Rapamycin and FK 506 on Rat Sertoli Cells In Vitro
The Immunosuppressant Rapamycin Induces Inactivation
Effect of immunosuppressants FK506 and Rapamycin on the function of progesterone receptor: protein” p59-HBI”, intersection between immunology and endocrinology …
Effects of Rapamycin on the proliferation and the prodution of IL-2, IFN-γ, TNF-α of spleniclymphocytes in mice [J]
Rapamycin-inducible Secretion of a Therapeutic Protein in the Eye After Transduction With Viral Vectors
High performance liquid chromatographic isolation and spectroscopic characterization of metabolites from the bile of rats receiving Rapamycin (sirolimus) …
In vitro IgE production by interleukin 4-stimulated human peripheral blood mononuclear cells is suppressed by Rapamycin
Conformational sensitivity analysis of FKBP–FK506/Rapamycin complexes
Rapamycin (sirolimus, RapamuneTM): A novel immunosuppressive agent
Cytokine expression in a stringent, single-dose Rapamycin, renal allograft model
Induction of Rapamycin sensitivity by the Gli oncogene.
Conversion from cyclosporine to Rapamycin in renal transplant recipients-Report of an initial experience.
IL-2 DEPENDENT Rapamycin RESISTENT SIGNALS ARE REQUIRED FOR TOLERANCE INDUCTION AND T CELL APOPTOSIS
Supercritical fluid chromatography for therapeutic drug monitoring of immunosuppressants: selectivity for cyclosporine A, FK 506 (tacrolimus), and Rapamycin
Total syntheses of Rapamycin and 32-(S)-dihydroRapamycin.
Rapamycin does not improve renal function or reduce profibrotic gene expression in chronic allograft nephropathy
THE Rapamycin ANALOGUE SDZ RAD INHIBITS LPS AND ANTI-CD3mAb INDUCED IL-10 SYNTHESIS IN VITRO AND IN HUMAN RENAL ALLOGRAFT …
Studies directed towards the synthesis of Rapamycin
Choosing rational combinations of therapeutic agents: Contrasting effects of costimulation blockade plus Rapamycin or cyclosporin on intragraft expression of …
Effects of FK506 and Rapamycin on formation of the neural tube in chick embryos
Increased LFA-1-mediated homotypic cell adhesion is associated with the G1 growth arrest induced by Rapamycin in a T cell lymphoma
The biosynthesis of Rapamycin
Studies towards the total synthesis of Rapamycin
FOUR-YEAR CONTROL OF A CLINICAL Rapamycin ASSAY
Control of translation by a novel, Rapamycin-sensitive signaling pathway.
The total synthesis of (-)-Rapamycin
Total synthesis of Rapamycin.
Rapamycin inhibits HMGB1 expression and releases in RAW264. 7 cells induced by lipopolysaccharides in vitro
Effects of Rapamycin and insulin on the cell cycle and apoptosis of hybridoma cell cultures
Rapamycin inhibits proliferating cell nuclear antigen expression and arrests keratinocytes in the G 1 phase of the cell cycle in vitro.
The Immunophilin Ligand Rapamycin: A Probe for the Analysis of the Relationship of Apoptosis to the Cell Cycle
Comparison between effects of mycophenolate mofetil and Rapamycin on proliferation and apoptosis of cyst-lining epithelial cells of ADPKD patients
Synthetic methods directed towards the synthesis of Rapamycin.
… ALLOGRAFT NEPHROPATHY: A PROSPECTIVE RANDOMISED TRIAL OF CYCLOSPORIN REDUCTION WITH OR WITHOUT Rapamycin.: Abstract# 432 Poster …
Methionine Interference in Rapamycin
Evaluation of the Influence of FK 506, Rapamycin, and Cyclosporine on Processing and Presentation of Particulate Antigen by Macrophages: Assessment of a …
Sirolimus (Rapamycin) monotherapy prevents graft vascular disease in non-human primates
Use of anti-CD25 monoclonal antibody in combination with Rapamycin to reduce or eliminate cyclosporine treatment during the induction phase of …
Efficacy of 40-O-(2-hydroxyethyl)-Rapamycin in preventing chronic renal allograft rejection in rats
Effect of cyclosporin A, FK506 and Rapamycin on proliferation and soluble IL-2 receptor release from mitogenically stimulated rat spleen cells
Coadministered neoral and the new Rapamycin derivative, SDZ RAD, for nonhuman primate lung transplantation: systematic pharmcokinetic-based trials to maximize …
Effects of Rapamycin on number and activity of endothelial progenitor cells
Total Synthesis of Rapamycin
Rapamycin has no effect on established allograft vasculopathy
Total Synthesis of Rapamycin
Therapeutic monitoring of cyclosporine, FK-506, and Rapamycin
Insensitivity towards inhibition by cyclosporin A, Rapamycin and tacrolimus in human intestinal lamina propria T lymphocytes
Cyclosporine but not Rapamycin stimulates endothelin-1 secretion by endothelial cells: Potential significance in transplant vasculopathy
Rapamycin RESCUE IN PEDIATRIC LIVER RECIPIENTS WITH TACROLIMUS TOXICITY. A PRELIMINARY EFFECT: CONCENTRATION ANALYSIS.: Abstract# 210 …
Studies towards the total synthesis of Rapamycin
Inhibitory Effects of Rapamycin on the Experimental Allograft Rejection
Innovative technique for immunosuppresion involving administration of Rapamycin loaded formed blood elements
Regulation and identification of Rapamycin sensitive phosphorylation sites of p70s6k
Studies directed toward the synthesis of the southern fragment of Rapamycin
Inhibitors of Mammalian Target of Rapamycin
Effect of Rapamycin on allograft rejection and immune response in mice
In vitro and in vivo assessment of Rapamycin as an immunosuppressive agent in the rabbit
Synthetic studies on the C10-C17 fragment of Rapamycin
Effects of Rapamycin on the proliferation and the prodution of IL-2, IFN-?, TNF-? of spleniclymphocytes in mice
Synergism between corticosteroids and Rapamycin for the treatment of intraocular inflammation
Rapamycin and C (27)-demethoxyRapamycin: An efficient stereocontrolled synthesis of the C (1)-C (20) and C (22)-C (26) fragments.
The effect of Rapamycin in prologation of adrenal allograft survival in the rat
inhibition of cellular transfer of experimental autoimmune uveoretinitis by Rapamycin
Rapamycin and other natural products affect regulation of the growth and differentiation of Saccharomyces cerevisiae.
Biosynthesis of Rapamycin by streptomyces hygroscopicus
Rapamycin, FRAP and the Control of 5’TOP mRNA Translation
Synergistic effects of mycophenolate mofetil (MMF) and sirolimus (Rapamycin, RAPA) in prevention of acute heart, pancreas and kidney allograft rejection and in …
Therapeutic window of whole blood Rapamycin concentration in recipients of renal transplantation
Syntheses and biological activities of natural products: Rapamycin, balanol and the maduropeptin chromophore.
The immunosuppressive effect of Rapamycin on lymphocytic proliferation and DTH, GVHR
Risk factors for Rapamycin-induced thrombocytopenia and leukopenia in renal transplant recipients
Immunosuppressive effect of Rapamycin on heart allotransplantation in the rat [J]
The effect of soy protein on serum lipids in kidney transplant patients receiving Rapamycin.
Aberrant expression of mammalian target of Rapamycin in stage ⅢB colon cancer and its significance
Rapamycin Inhibits 3T3-L1 Adipocyte Differentiation Independent of Clonal Expansion
Effect of Rapamycin on the cyclosporin A-resistant CD28-mediated
Synthetic approaches to the tricarbonyl subunit of Rapamycin
Molecular mechanisms of action of the immunosuppressive drugs cyclosporin A, FK506 and Rapamycin.
Effects of Rapamycin on chronic nephrotoxicity induced by cyclosporine A in rats
Rapamycin antagonizes interleukin-6 mediated growth arrest and differentiation of myeloblastic M1 cells
Cyclin D3, a key cyclin in human lymphocyte proliferation and Rapamycin-mediated immunosuppression.
EXTREME HYPERLIPIDEMIA RESULTING FROM Rapamycin-DERIVED DRUG ADMINISTRATION.: Abstract# 827 Poster Board#-Session: P84-III
Siloxanes as templates in asymmetric synthesis: Studies directed towards the synthesis of Rapamycin.
FK 506 versus cyclosponne a for steroid-free synergistic combination therapy with Rapamycin in a discordant large animal donor xenoislet transplant model
Studies of the Rapamycin-sensitive signaling network using genomics, chemical genetics, and small molecule microarrays.
Rapamycin increases the expression of genes responsible for extracellular matrix remodelling compared to neoral in rat allografts
Inhibitory effects of Rapamycin on intimal hyperplasia after PTCA in the porcine coronary model: a 3-month follow-up
Regulation of the cell integrity pathway by Rapamycin-sensitive TOR function in budding yeast
Rapamycin Inhibits Estrogen-Mediated Transcription in Breast Cancer Cell Lines
Tissue Distribution of Rapamycin and Cyclosporine in the Rat: Comparison of Single vs. Dual Drug Therapy
inhibition by Rapamycin of PDGF-and bFGF-induced human tenon fibroblast proliferation in vitro
Effects of Rapamycin and wortmannin on the insulin stimulation of protein synthesis in rat skeletal muscle and L6 myoblasts
The expression of mammalian target of Rapamycin in autogenous vein graft in rats
The Effects of Immunosuppressants Rapamycin and Cyclosporin A on the Proliferation, Cell Cycle, and Cyclin Expression of Cultured Human Keratinocyte Cell Line …
The effects of Rapamycin and cyclosporin a on tolerance induction through bone marrow transplantation with costimulation blockade
Cyclosporin and FK506, but not Rapamycin, increase DNFB induced TNF-alpha expression in human epidermal sheets.
Mass spectrometric analysis of the Rapamycin-dependent phosphorylation sites of the yeast protein kinase NPR1
Effects of stent-based delivery of Rapamycin and methotrexate on neointimal formation in a porcine coronary model
Effects of cyclosporin and Rapamycin on the in vitro activation of human CD8+ lymphocytes in comparison with peripheral blood mononuclear cells.
Evaluation of Rapamycin coated stents by multi row detector computed angiography: comparison to quantitative angiographic results
Cyclosporin A and FK506, but not Rapamycin, increase DNFB induced TNF-alpha expression in human epidermal sheets.
Using natural products to elucidate molecular events within cells: Molecular mechanisms of action of cyclosporine, FK506, and Rapamycin.
SDZ-RAD PREVENTS CYCLOSPORINE-INDUCED inhibition OF BRAIN ENERGY METABOLISM: COMPARISON WITH Rapamycin.: Abstract# 314 Poster Board …
Rapamycin POTENTIATES NF-κB AND AP-1 ACTIVATION IN TNF-α TREATED PRIMARY RAT HEPATOCYTES.: Abstract# 308 Poster Board#-Session: P155-I
The Mechanism of Insulin-Induced Clonal Expansion in Adipocyte Differentiation–the Importance of PI3 Kinae-Rapamycin-Sensitive Pathway
Inhibitory effects of Rapamycin and ascomycin on hair growth induced by cyclosporin A and FK506 in mice.
Effects of Rapamycin-treated HSP60-pulsed dendritic cells on the progression of the atherosclerotic plaque in mice
inhibition of S6 Kinase by Rapamycin Blocks Maturation of Rana dybowskii Oocytes
Relationship between multiple biological effects of Rapamycin and the inhibition of pp70 S6 protein kinase activity: Analysis in mutant clones of a T cell lymphoma.
The study of Rapamycin-eluting polymer-coated stents to prevent restenosis in the porcine coronary injury model
Differential effects of cyclosporine and Rapamycin on costimulation blockade induced allograft tolerance: Intragraft CTL gene expression analysis
BRIEF COMMUNICATIONS: EFFECT OF Rapamycin ON RENAL ALLOGRAFT SURVIVAL IN CANINE RECIPIENTS TREATED WITH ANTILYMPHOCYTE SERUM …
Rapamycin RESCUE IN PEDIATRIC LIVER RECIPIENTS WITH TACROLIMUS TOXICITY.: Abstract# 211 Poster Board#-Session: P58-I
Rapamycin (RAPA) lowers dose requirements of cyclosporin (CsA) in renal transplant patients (RTx)
… Lewis acid-mediated Mukaiyama aldol reaction of α-alkoxythiolketene acetals with α, β-disubstituted enals: synthesis of the C26–C33 segment of Rapamycin
Rapamycin selectively inhibits translation of mRNAs encoding elongation factor and ribosomal protein
FK506 versus CSA for steroid-free synergistic combination therapy with Rapamycin (Rapa) in a discordant xenoislet model
SHORT TERM ANTILYMPHOCYTE SERUM, Rapamycin AND DONOR BONE MARROW SIGNIFICANTLY SUPPRESS ANTIDONOR ANTIBODY AND PROLONG …
… studies n bioactive natural products. Part I, An approach towards the nootrophic agent huperzine A. Part II, Synthesis of the tricarbonyl subunit of Rapamycin
EFFECT OF TACROLIMUS (FK506) AND SIROLIMUS (Rapamycin) MONO-AND COMBINATION THERAPY IN PROLONGATION OF RENAL ALLOGRAFT …
Coadministration of neoral and the novel Rapamycin analog, sdzrad, to. lung allograft recipients: potentiation of immunosuppressive efficacy and reduction of toxicity …
Rapamycin (Rapa) And Cyclosporin A (Csa) Enhance Transforming Growth Factor Beta (TGF-β1) Expression in Immortalized Rat Proximal Tubules (IRPTC)† 1840
Rapamycin (RAPA) ENHANCES TRANSFORMING GROWTH FACTOR BETA (TGF-β1) EXPRESSION IN IMMORTALIZED RAT PROXIMAL TUBULES CELLS …
Prevention of Arterial Restenosis by Rapamycin and Mycophenolate Mofetil: A New Role for Novel Immunosuppressants in the Prevention of Post-Balloon Angioplasty …
Rapamycin synergizes with dst plus anti-CD154 to block auto and allo-immune response and induce islet allograft engraftment in spontaneous autoimmune diabetic …
Mating stimulate protein phosphorylation and synthesis via Rapamycin-and wortmannin-sensitive manner in male accessory glands of D. melanogaster
Combined use of mycophenolate mofetil (MMF) and Rapamycin (RAPA) in prevention of acute heart allograft rejection and reversal of ongoing cardiac allograft …
Chronic Rejection in Non-human Primates: Sirolimus (Rapamycin), but not Cyclosporin, Prevents Graft Vascular Disease (GVD) in Aortic Allografts after Acute …
Provocative effects of the immunosuppressants Rapamycin, tacrolimus, and dexamethasone on Pneumocystis carinii pneumonitis in contrast to the anti-Pneumocystis …
Synthesis of the C-21-C-42 fragment of Rapamycin and total synthesis of Rapamycin.
PMA Induced Ser/Thr Phosphorylation of IRS-1 Mediated by Rapamycin-Sensitive Pathway
Desensitization of Insulin Action through Ser/Thr Phosphorylation and Degradation of IRS-1 by Activation of Rapamycin-Sensitive Pathway
24 HPLC (ESI)-MS IDENTIFICATION OF SIROLIMUS (Rapamycin) METABOLITES GENERATED IN A RABBIT MICROSOMAL SYSTEM AND CONFIRMATION WITH …
Interleukin-2 and Rapamycin regulation of cyclin E-Cdk2 kinase, the Cdk inhibitor, P27KIP1, and the T lymphocyte cell cycle.
192 SENSITIVE AND SPECIFIC QUANTIFICATION OF SIROLIMUS (Rapamycin) AND ITS METABOLITES IN BLOOD AND URINE OF KIDNEY GRAFT RECIPIENTS …
OP-4. Studies towards the Total Synthesis of Rapamycin
74 DETERMINATION OF Rapamycin IN WHOLE BLOOD BY HPLC
# 680 In vitro evaluation of Rapamycin sensitivity and synergy with cisplatin and camptothecin in medulloblastoma
Purification and characterization of a 50 kiloDalton lymphocyte-derived binding protein for cyclosporin, FK-506 and Rapamycin.
… from carbohydrates: Application of the (2, 3)-Wittig rearrangement of carbohydrate-derived alpha-alkoxy tertiary allylic ethers to the syntheses of Adda and Rapamycin.
Efficacy of FK-506 and Rapamycin in Prolongation of Allograft Rat Limb Survival
# 764 Rapamycin effects phosphorylation of p70S6 kinase and other intermediaries in medulloblastoma
I. The formal synthesis of FK-506. II. A simple synthesis of vicinal tricarbonyls. III. Studies toward the synthesis of Rapamycin.
Glucose-induced polypyrimidine-tract-binding protein (PTB) to the 3´-untranslated region of the insulin mRNA is inhibited by Rapamycin
METABOLISM AND PHARMACOKINETICS OF THE NEW IMMUNOSUPPRESSANT 40-O-(2-HYDROXY)-ETHYL-Rapamycin
138 Rapamycin AND CYCLOSPORINE DRUG STUDIES IN THE RAT MODEL
Rapamycin: an anti-cancer immunosuppressant?
Determinants of Rapamycin sensitivity in breast cancer cells
Antileukemic activity of Rapamycin in acute myeloid leukemia
Molecular organization of target of Rapamycin complex 2
Rapamycin-induced oligospermia
mTOR-targeted therapy of cancer with Rapamycin derivatives
Rapamycin pre-treatment protects against apoptosis
Activation of Akt and eIF4E survival pathways by Rapamycin-mediated mammalian target of Rapamycin inhibition
Signaling by target of Rapamycin proteins in cell growth control
Differential effects of Rapamycin on mammalian target of Rapamycin signaling functions in mammalian cells
Rapamycin alleviates toxicity of different aggregate-prone proteins
Prolonged Rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
Rapamycin attenuates load-induced cardiac hypertrophy in mice
Use of Rapamycin slows progression of cardiac transplantation vasculopathy
Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease
Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
Rapamycin is an effective inhibitor of human renal cancer metastasis
Maintenance immunosuppression with target-of-Rapamycin inhibitors is associated with a reduced incidence of de novo malignancies
Rapamycin causes regression of astrocytomas in tuberous sclerosis complex
Campath‐1H induction plus Rapamycin monotherapy for renal transplantation: results of a pilot study
Phosphorylation of Mammalian Target of Rapamycin (mTOR) at Ser-2448 IsMediated by p70S6 Kinase
Target of Rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
Pathological angiogenesis is induced by sustained Akt signaling and inhibited by Rapamycin
Characterization of the FKBP⊙ Rapamycin⊙ FRB Ternary Complex
inhibition of target of Rapamycin signaling by Rapamycin in the unicellular green alga Chlamydomonas reinhardtii
Insulin/IGF and target of Rapamycin signaling: a TOR de force in growth control
Targeting the molecular target of Rapamycin (mTOR)
inhibition of mTOR signaling with Rapamycin regresses established cardiac hypertrophy induced by pressure overload
The molecular target of Rapamycin (mTOR) as a therapeutic target against cancer
Regulation of adipocyte differentiation and insulin action with Rapamycin
Effects of Rapamycin in the Eker rat model of tuberous sclerosis complex
Targeting the mammalian target of Rapamycin (mTOR): a new approach to treating cancer
Target of Rapamycin-mediated amino acid signaling in mosquito anautogeny
Multiple roles of Tap42 in mediating Rapamycin-induced transcriptional changes in yeast
Rapamycin impairs antigen uptake of human dendritic cells1
Rapamycin-eluting stents for the treatment of bifurcated coronary lesions: a randomized comparison of a simple versus complex strategy
Mammalian target of Rapamycin inhibition as therapy for hematologic malignancies
Dissociation of raptor from mTOR is a mechanism of Rapamycin‐induced inhibition of mTOR function
GβL, a positive regulator of the Rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
Mammalian target of Rapamycin: a new molecular target for breast cancer
Combination of Rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs
A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of Rapamycin and its targets
Immunosuppressants and skin cancer in transplant patients: focus on Rapamycin
Rapamycin promotes expansion of functional CD4+ CD25+ FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients
Specific binding to intracellular proteins determines arterial transport properties for Rapamycin and paclitaxel
Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells
Targeting mammalian target of Rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells
Upstream of the mammalian target of Rapamycin: do all roads pass through mTOR?
Rictor, a novel binding partner of mTOR, defines a Rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
Phospholipase D confers Rapamycin resistance in human breast cancer cells
Thr2446 is a novel mammalian target of Rapamycin (mTOR) phosphorylation site regulated by nutrient status
Nephrotoxicity of Rapamycin: an emerging problem in clinical medicine
Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity
The mammalian target of Rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity
Rapamycin attenuates unilateral ureteral obstruction-induced renal fibrosis
Rapamycin reduces disease activity and normalizes T cell activation–induced calcium fluxing in patients with systemic lupus erythematosus
Rapamycin suppresses experimental aortic aneurysm growth
Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signaling
Rapamycin has a deleterious effect on MIN-6 cells and rat and human islets
Antiangiogenic potential of the mammalian target of Rapamycin inhibitor temsirolimus
Mammalian TOR complex 2 controls the actin cytoskeleton and is Rapamycin insensitive
Rapamycin protects allografts from rejection while simultaneously attacking tumors in immunosuppressed mice
The Pim kinases control Rapamycin-resistant T cell survival and activation
Akt activates the mammalian target of Rapamycin by regulating cellular ATP level and AMPK activity
Mammalian target of Rapamycin, a molecular target in squamous cell carcinomas of the head and neck
Finding new components of the target of Rapamycin (TOR) signaling network through chemical genetics and proteome chips
Stent implantation activates RhoA in human arteries: inhibitory effect of Rapamycin
Regulation of targets of mTOR (mammalian target of Rapamycin) signalling by intracellular amino acid availability.
Rapamycin for treatment of chronic allograft nephropathy in renal transplant patients
Sustained activation of the JNK cascade and Rapamycin-induced apoptosis are suppressed by p53/p21Cip1
Combination of the mTOR inhibitor Rapamycin and CC-5013 has synergistic activity in multiple myeloma
Rapamycin and interleukin-10 treatment induces T regulatory type 1 cells that mediate antigen-specific transplantation tolerance
Gene expression-based chemical genomics identifies Rapamycin as a modulator of MCL1 and glucocorticoid resistance
Rapamycin activates Tap42‐associated phosphatases by abrogating their association with Tor complex 1
Preliminary observations regarding angiographic pattern of restenosis after Rapamycin-eluting stent implantation
Mutasynthesis of Rapamycin analogues through the manipulation of a gene governing starter unit biosynthesis
Curcumin inhibits the mammalian target of Rapamycin‐mediated signaling pathways in cancer cells
Mammalian target of Rapamycin pathway blockade slows progression of diabetic kidney disease in rats
The solution structure of the FATC domain of the protein kinase target of Rapamycin suggests a role for redox-dependent structural and cellular stability
Mammalian target of Rapamycin regulates IRS-1 serine 307 phosphorylation
The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of Rapamycin pathway
Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+ subset of human CD4+CD25+ regulatory T cells
Insights into TOR function and Rapamycin response: chemical genomic profiling by using a high-density cell array method
Survival signaling by Notch1: mammalian target of Rapamycin (mTOR)–dependent inhibition of p53
Antitumoral activity of Rapamycin in renal angiomyolipoma associated with tuberous sclerosis complex
Rapamycin successfully treats post‐transplant autoimmune hepatitis
Increased activation of the mammalian target of Rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance
Rapamycin: signaling in vascular smooth muscle
Therapeutic potential of target of Rapamycin inhibitors
Synergistic augmentation of Rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors
Rapamycin inhibits proliferation and differentiation of human endothelial progenitor cells in vitro
Rheb binding to mammalian target of Rapamycin (mTOR) is regulated by amino acid sufficiency
Rapamycin-sensitive pathway regulates mitochondrial membrane potential, autophagy, and survival in irradiated MCF-7 cells
Inhibitory effect of Rapamycin on corneal neovascularization in vitro and in vivo
Regulation of peroxisome proliferator–activated receptor-γ activity by mammalian target of Rapamycin and amino acids in adipogenesis
inhibition of mTOR signaling with Rapamycin attenuates renal hypertrophy in the early diabetic mice
Identification of S6 kinase 1 as a novel mammalian target of Rapamycin (mTOR)-phosphorylating kinase
Rapamycin inhibits IL-4—induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo
Mammalian target of Rapamycin inhibition
Phase I/II study of the mammalian target of Rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies
Mechanical stimuli regulate Rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B-and growth factor-independent mechanism
Dosing of Rapamycin is critical to achieve an optimal antiangiogenic effect against cancer
A possible linkage between AMP‐activated protein kinase (AMPK) and mammalian target of Rapamycin (mTOR) signalling pathway
Rapamycin induces tumor-specific thrombosis via tissue factor in the presence of VEGF
Acute Rapamycin nephrotoxicity in native kidneys of patients with chronic glomerulopathies
Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone
AKT activity determines sensitivity to mammalian target of Rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression
Inhibitors of the mammalian target of Rapamycin
Homodirectional changes in transcriptome composition and mRNA translation induced by Rapamycin and heat shock
Rapamycin, but not FK-506, increases endothelial tissue factor expression: implications for drug-eluting stent design
Oral Rapamycin after coronary bare-metal stent implantation to prevent restenosis: the Prospective, Randomized Oral Rapamycin in Argentina (ORAR II) Study
Rapamycin-mediated inhibition of mammalian target of Rapamycin in skeletal muscle cells reduces glucose utilization and increases fatty acid oxidation
Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma
Rapamycin inhibits the growth and metastatic progression of non-small cell lung cancer
Effect of Rapamycin alone and in combination with antiangiogenesis therapy in an orthotopic model of human pancreatic cancer
Efficacy of a Rapamycin analog (CCI‐779) and IFN‐γ in tuberous sclerosis mouse models
Rapamycin confers preconditioning-like protection against ischemia–reperfusion injury in isolated mouse heart and cardiomyocytes
Drosophila target of Rapamycin kinase functions as a multimer
Targeting the Akt/mammalian target of Rapamycin pathway for radiosensitization of breast cancer
A selective small molecule c-MET Inhibitor, PHA665752, cooperates with Rapamycin
Arabidopsis TARGET OF Rapamycin interacts with RAPTOR, which regulates the activity of S6 kinase in response to osmotic stress signals
Rapamycin in cardiovascular medicine
Mechanical stimuli and nutrients regulate Rapamycin‐sensitive signaling through distinct mechanisms in skeletal muscle
FKBP12-Rapamycin-associated protein or mammalian target of Rapamycin (FRAP/mTOR) localization in the endoplasmic reticulum and the Golgi apparatus
S6K1−/−/S6K2−/− mice exhibit perinatal lethality and Rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein …
Determinants of sensitivity and resistance to Rapamycin-chemotherapy drug combinations in vivo
Brain-derived neurotrophic factor induces mammalian target of Rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal …
In vitro study of release mechanisms of paclitaxel and Rapamycin from drug-incorporated biodegradable stent matrices
The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of Rapamycin by amino acids and certain cellular stresses
Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways
Rapamycin‐sensitive signalling in long‐term consolidation of auditory cortex‐dependent memory
Systemic Rapamycin inhibits retinal and choroidal neovascularization in mice
inhibition of the mammalian target of Rapamycin (mTOR) by Rapamycin increases chemosensitivity of CaSki cells to paclitaxel
Target of Rapamycin inhibitors (sirolimus and everolimus) for primary immunosuppression of kidney transplant recipients: a systematic review and meta-analysis of …
Rapamycin‐treated, alloantigen‐pulsed host dendritic cells induce ag‐specific T cell regulation and prolong graft survival
Activation of mammalian target of Rapamycin in cytomegalic neurons of human cortical dysplasia
Mutation in TSC2 and activation of mammalian target of Rapamycin signalling pathway in renal angiomyolipoma
inhibition of mammalian target of Rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cells
Role of mammalian target of Rapamycin signaling in compensatory renal hypertrophy
Rapamycin synergizes with the epidermal growth factor receptor inhibitor erlotinib in non–small-cell lung, pancreatic, colon, and breast tumors
Rapamycin ameliorates proteinuria-associated tubulointerstitial inflammation and fibrosis in experimental membranous nephropathy
Activation of the Akt/mammalian target of Rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers
Autophagy for cancer therapy through inhibition of pro-apoptotic proteins and mammalian target of Rapamycin signaling
BDNF regulates the translation of a select group of mRNAs by a mammalian target of Rapamycin-phosphatidylinositol 3-kinase-dependent pathway during neuronal …
Antitumor efficacy of intermittent treatment schedules with the Rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in …
The mammalian target of Rapamycin signaling network and gene regulation
Combination mammalian target of Rapamycin inhibitor Rapamycin and HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin has synergistic activity in multiple …
Role of glycogen synthase kinase 3β in Rapamycin-mediated cell cycle regulation and chemosensitivity
Immediate response of mammalian target of Rapamycin (mTOR)‐mediated signalling following acute resistance exercise in rat skeletal muscle
Proteomic analysis reveals hyperactivation of the mammalian target of Rapamycin pathway in neurofibromatosis 1–associated human and mouse brain tumors
Rapamycin (sirolimus) for treatment of chronic graft-versus-host disease
Mutual antagonism of target of Rapamycin and calcineurin signaling
Rapamycin inhibits the interleukin 10 signal transduction pathway and the growth of Epstein Barr virus B-cell lymphomas
inhibition of corneal neovascularization by Rapamycin
Calcineurin inhibitors, but not Rapamycin, reduce percentages of CD4+ CD25+ FOXP3+ regulatory T cells in renal transplant recipients
Androgens induce prostate cancer cell proliferation through mammalian target of Rapamycin activation and post-transcriptional increases in cyclin D proteins
Dexamethasone represses signaling through the mammalian target of Rapamycin in muscle cells by enhancing expression of REDD1
In vitro release of the mTOR inhibitor Rapamycin from poly (ethylene glycol)-b-poly (ε-caprolactone) micelles
Low-dose oral Rapamycin treatment reduces fibrogenesis, improves liver function, and prolongs survival in rats with established liver cirrhosis
Antitumor activity of Rapamycin in a transgenic mouse model of ErbB2-dependent human breast cancer
Translational control via the mammalian target of Rapamycin pathway is critical for the formation and stability of long-term fear memory in amygdala neurons
Rapamycin induces Smad activity in prostate cancer cell lines
Resistance exercise increases muscle protein synthesis and translation of eukaryotic initiation factor 2Bϵ mRNA in a mammalian target of Rapamycin …
Differential effect of calcineurin inhibitors, anti-CD25 antibodies and Rapamycin on the induction of FOXP3 in human T cells
The mammalian target of Rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif
Effects of the mammalian target of Rapamycin inhibitor CCI-779 used alone or with chemotherapy on human prostate cancer cells and xenografts
Rapamycin inhibits doxorubicin-induced NF-κB/Rel nuclear activity and enhances the apoptosis of melanoma cells
Spatial memory formation and memory-enhancing effect of glucose involves activation of the tuberous sclerosis complex–mammalian target of Rapamycin pathway
Rapamycin induces heme oxygenase-1 in human pulmonary vascular cells: implications in the antiproliferative response to Rapamycin
New targets for therapy in breast cancer: mammalian target of Rapamycin (mTOR) antagonists
Modulation of the mammalian target of Rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid
Human cytomegalovirus infection induces Rapamycin-insensitive phosphorylation of downstream effectors of mTOR kinase
Mammalian target of Rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor …
… predictors of angiographic restenosis after sirolimus-eluting stent implantation in complex patients: an evaluation from the Rapamycin-Eluting Stent Evaluated At …
Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of Rapamycin
Ischemia-reperfusion induces glomerular and tubular activation of proinflammatory and antiapoptotic pathways: differential modulation by Rapamycin
Rpd3p relocation mediates a transcriptional response to Rapamycin in yeast
Plumbagin induces G2-M arrest and autophagy by inhibiting the AKT/mammalian target of Rapamycin pathway in breast cancer cells
Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of Rapamycin kinase inhibitor, in patients with advanced refractory renal cell …
Rapamycin-associated post-transplantation glomerulonephritis and its remission after reintroduction of calcineurin-inhibitor therapy
Activation of the mammalian target of Rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes
Akt1 Activation Can Augment Hypoxia-Inducible Factor-1α Expression by Increasing Protein Translation through a Mammalian Target of Rapamycin–Independent …
Rapamycin inhibits GM-CSF-induced neutrophil migration
The mammalian target of the Rapamycin (mTOR) kinase pathway: its role in tumourigenesis and targeted antitumour therapy
Delayed graft function and cast nephropathy associated with tacrolimus plus Rapamycin use
Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the Rapamycin gene cluster
Recent developments in targeting the mammalian target of Rapamycin (mTOR) kinase pathway
Domains of Gln3p interacting with karyopherins, Ure2p, and the target of Rapamycin protein
Rapamycin-eluting stents for the treatment of unprotected left main coronary disease
Rapamycin induces regression of endometriotic lesions by inhibiting neovascularization and cell proliferation
Activation of mammalian target of Rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase–positive anaplastic large cell …
Rapamycin-induced endothelial cell death and tumor vessel thrombosis potentiate cytotoxic therapy against pancreatic cancer
Activation of mammalian target of Rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1
Mammalian target of Rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma …
inhibition of mammalian target of Rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras
Raptor, a binding partner of target of Rapamycin
Rapamycin-mediated enrichment of T cells with regulatory activity in stimulated CD4+ T cell cultures is not due to the selective expansion of naturally occurring …
Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS)
Molecular mechanisms through which amino acids mediate signaling through the mammalian target of Rapamycin
… outcome after drug-eluting stent implantation for the percutaneous treatment of left main coronary artery disease: insights from the Rapamycin-Eluting and Taxus Stent …
Rapamycin biosynthesis: elucidation of gene product function
Effect of Rapamycin on mouse chronic lymphocytic leukemia and the development of nonhematopoietic malignancies in Eμ-TCL1 transgenic mice
Roles of glutamate receptors and the mammalian target of Rapamycin (mTOR) signaling pathway in activity-dependent dendritic protein synthesis in …
New Rapamycin derivatives by precursor‐directed biosynthesis
Thyroid Hormone Induces Rapid Activation of Akt/Protein Kinase B-Mammalian Target of Rapamycin-p70S6K Cascade through Phosphatidylinositol 3-Kinase in …
Target of Rapamycin-dependent activation of S6 kinase is a central step in the transduction of nutritional signals during egg development in a mosquito
inhibition of mammalian target of Rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity
… growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin (PI3K/Akt/mTOR) …
Novel role of the small GTPase Rheb: its implication in endocytic pathway independent of the activation of mammalian target of Rapamycin
Chronic inhibition of mammalian target of Rapamycin signaling downregulates insulin receptor substrates 1 and 2 and AKT activation: a crossroad between cancer and …
Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2α kinase GCN2
Control of dendritic arborization by the phosphoinositide-3′-kinase–Akt–mammalian target of Rapamycin pathway
Rapamycin induces the fusion-type independent downregulation of the EWS/FLI-1 proteins and inhibits Ewing’s sarcoma cell proliferation
Rapamycin-induced G1 arrest in cycling B-CLL cells is associated with reduced expression of cyclin D3, cyclin E, cyclin A, and survivin
Mammalian target of Rapamycin as a therapeutic target in leukemia
Activation of mammalian target of Rapamycin signaling promotes cell cycle progression and protects cells from apoptosis in mantle cell lymphoma
Nutrient-dependent multimerization of the mammalian target of Rapamycin through the N-terminal HEAT repeat region
Akt up-regulation increases resistance to microtubule-directed chemotherapeutic agents through mammalian target of Rapamycin
Mammalian target of Rapamycin (mTOR) inhibitors as anti-cancer agents
Long-term treatment of bile duct-ligated rats with Rapamycin (sirolimus) significantly attenuates liver fibrosis: analysis of the underlying mechanisms
Mechanism by which mammalian target of Rapamycin inhibitors sensitize multiple myeloma cells to dexamethasone-induced apoptosis
Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of Rapamycin
Mammalian target of Rapamycin inhibition induces cell cycle arrest in diffuse large B cell lymphoma (DLBCL) cells and sensitises DLBCL cells to rituximab
Tristetraprolin regulates Cyclin D1 and c-Myc mRNA stability in response to Rapamycin in an Akt-dependent manner via p38 MAPK signaling
The Rapamycin analog CCI-779 is a potent inhibitor of pancreatic cancer cell proliferation
Pilot trial of oral Rapamycin for recalcitrant restenosis
Effect of Rapamycin on renal ischemia‐reperfusion injury in mice
Rapamycin delays but does not prevent recovery from acute renal failure: role of acquired tubular resistance
ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of Rapamycin/p70S6K leading to increased angiogenesis and …
Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression
Successful conversion to Rapamycin for calcineurin inhibitor-related neurotoxicity following liver transplantation
Synergistic effect of targeting mTOR by Rapamycin and depleting ATP by inhibition of glycolysis in lymphoma and leukemia cells
Cyclosporin A and tacrolimus, but not Rapamycin, inhibit MHC-restricted antigen presentation pathways in dendritic cells
Rapamycin inhibits growth and survival of D816V-mutated c-kit mast cells
United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of Rapamycin (mTOR) signalling
Target of Rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding …
… sunitinib (formerly SU11248) against a variety of human hematologic malignancies: enhancement of growth inhibition via inhibition of mammalian target of Rapamycin …
Rapamycin attenuates atherosclerosis induced by dietary cholesterol in apolipoprotein-deficient mice through a p27Kip1-independent pathway
Mammalian target of Rapamycin positively regulates collagen type I production via a phosphatidylinositol 3-kinase-independent pathway
Human cytomegalovirus infection alters the substrate specificities and Rapamycin sensitivities of raptor-and rictor-containing complexes
Regulation of Leucine Uptake by tor1+ in Schizosaccharomyces pombe Is Sensitive to Rapamycin
TCR engagement increases hypoxia-inducible factor-1α protein synthesis via Rapamycin-sensitive pathway under hypoxic conditions in human peripheral T cells
Early outcome after sirolimus-eluting stent implantation in patients with acute coronary syndromes: insights from the Rapamycin-Eluting Stent Evaluated At Rotterdam …
Mammalian target of Rapamycin (mTOR) signaling is required for a late-stage fusion process during skeletal myotube maturation
Local application of Rapamycin inhibits neointimal hyperplasia in experimental vein grafts
Cyclin D1 and c-myc internal ribosome entry site (IRES)-dependent translation is regulated by AKT activity and enhanced by Rapamycin through a p38 MAPK …
GATA factor translation is the final downstream step in the amino acid/target-of-Rapamycin-mediated vitellogenin gene expression in the anautogenous …
Rapamycin attenuates atherosclerotic plaque progression in apolipoprotein E knockout mice: inhibitory effect on monocyte chemotaxis
Rapamycin attenuates vascular wall inflammation and progenitor cell promoters after angioplasty
Akt1/Akt2 and mammalian target of Rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell …
Fibronectin stimulates non–small cell lung carcinoma cell growth through activation of Akt/mammalian target of Rapamycin/S6 kinase and inactivation of LKB1/AMP …
Activation of the phosphoinositide 3-kinase-Akt-mammalian target of Rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long …
Rapamycin causes down-regulation of CCR5 and accumulation of anti-HIV β-chemokines: an approach to suppress R5 strains of HIV-1
… in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson’s disease by a mechanism involving mammalian target of Rapamycin …
Glucagon represses signaling through the mammalian target of Rapamycin in rat liver by activating AMP-activated protein kinase
Isolation and Characterization of Pre‐Rapamycin, the First Macrocyclic Intermediate in the Biosynthesis of the Immunosuppressant Rapamycin by S. hygroscopicus
Type D personality predicts death or myocardial infarction after bare metal stent or sirolimus-eluting stent implantation: a Rapamycin-Eluting Stent Evaluated at …
A high-throughput method for screening of Rapamycin-producing strains of Streptomyces hygroscopicus by cultivation in 96-well microtiter plates
Phosphatidic acid regulates systemic inflammatory responses by modulating the Akt-mammalian target of Rapamycin-p70 S6 kinase 1 pathway
Comparative effects of paclitaxel and Rapamycin on smooth muscle migration and survival: role of AKT-dependent signaling
Production of novel Rapamycin analogs by precursor-directed biosynthesis
Rapamycin inhibits telomerase activity by decreasing the hTERT mRNA level in endometrial cancer cells1
Effects of Rapamycin on number activity and eNOS of endothelial progenitor cells from peripheral blood
Predictive and prognostic role of activated mammalian target of Rapamycin in cervical cancer treated with cisplatin-based neoadjuvant chemotherapy
Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of Rapamycin (mTOR)-induced negative feedback down-regulates …
A Rapamycin derivative (everolimus) controls proliferation through down-regulation of truncated CCAAT enhancer binding protein β and NF-κB activity in Hodgkin and …
Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of Rapamycin and for recognition by raptor
A nuclear transport signal in mammalian target of Rapamycin is critical for its cytoplasmic signaling to S6 kinase 1
Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of Rapamycin (mTOR)-independent
… undergoing percutaneous intervention in the drug-eluting stent era: an integrated clinical and angiographic analysis based on the Rapamycin-Eluting Stent Evaluated …
Antiangiogenic and immunomodulatory effects of Rapamycin on islet endothelium: relevance for islet transplantation
Rapamycin mimics the incompatibility reaction in the fungus Podospora anserina
Rapamycin effects transcriptional programs in smooth muscle cells controlling proliferative and inflammatory properties
An open prospective pilot study on the use of Rapamycin after penetrating high-risk keratoplasty
Ex vivo Rapamycin generates Th1/Tc1 or Th2/Tc2 Effector T cells with enhanced in vivo function and differential sensitivity to post-transplant Rapamycin therapy
Post-transcriptional regulation of the androgen receptor by Mammalian target of Rapamycin
Rapamycin induces apoptosis of JN-DSRCT-1 cells by increasing the Bax: Bcl-xL ratio through concurrent mechanisms dependent and independent of its …
Efficacy of Rapamycin in patient with juvenile rheumatoid arthritis
Mammalian target of Rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiation
Effects of Rapamycin on accumulation of α‐, β‐ and γ‐globin mRNAs in erythroid precursor cells from β‐thalassaemia patients
Rapamycin and chronic kidney disease: beyond the inhibition of inflammation
Overexpressed eIF4E is functionally active in surgical margins of head and neck cancer patients via activation of the Akt/mammalian target of Rapamycin pathway
inhibition of the mammalian target of Rapamycin and the induction of cell cycle arrest in mantle cell lymphoma cells
LY294002 and Rapamycin co‐operate to inhibit T‐cell proliferation
The mTOR inhibitor Rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells
The immunosuppressant Rapamycin exacerbates neurotoxicity of Aβ peptide
… transcriptionally and posttranslationally through phosphatidylinositol 3′-kinase/Akt, heat shock protein 90, and mammalian target of Rapamycin in transformed NK …
From Rapa Nui to Rapamycin: targeting PI3K/Akt/mTOR for cancer therapy
Evidence for down-regulation of phosphoinositide 3-kinase/Akt/mammalian target of Rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways …
Statins induce mammalian target of Rapamycin (mTOR)-mediated inhibition of Akt signaling and sensitize p53-deficient cells to cytostatic drugs
Target of Rapamycin inhibitors (TOR‐I; sirolimus and everolimus) for primary immunosuppression in kidney transplant recipients
Phophatidylinositol-3 Kinase/Mammalian Target of Rapamycin/p70S6K Regulates Contractile Protein Accumulation in Airway Myocyte Differentiation
Amino acid signaling through the mammalian target of Rapamycin (mTOR) pathway: role of glutamine and of cell shrinkage
Rapamycin: friend, foe, or misunderstood?
Rapamycin inhibits growth of premalignant and malignant mammary lesions in a mouse model of ductal carcinoma in situ
The product of the UTH1 gene, required for Bax‐induced cell death in yeast, is involved in the response to Rapamycin
Effects of FK506 and Rapamycin on generation of reactive oxygen species, nitric oxide production and nuclear factor kappa B activation in rat hepatocytes
Sustained intraocular Rapamycin delivery effectively prevents high-risk corneal allograft rejection and neovascularization in rabbits
Effects of Rapamycin on the epithelial-to-mesenchymal transition of human peritoneal mesothelial cells
Mammalian target of Rapamycin
Rapamycin analogs for stent-based local drug delivery
Handicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/mammalian target of Rapamycin pathway
Differential effects of immunosuppressive drugs on chemokine receptor CCR7 in human monocyte-derived dendritic cells: selective upregulation by Rapamycin
Mutations in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of Rapamycin activity and increased translation under hypoxic conditions
Rapamycin disrupts cyclin/cyclin-dependent kinase/p21/proliferating cell nuclear antigen complexes and cyclin D1 reverses Rapamycin action by stabilizing these …
Mechanisms of action of Rapamycin in gliomas
Enhancement of translation elongation in neurons by brain‐derived neurotrophic factor: Implications for mammalian target of Rapamycin signaling
Oral Rapamycin to inhibit restenosis after stenting of de novo coronary lesions: the Oral Rapamune to Inhibit Restenosis (ORBIT) study
Effects of combined treatment with Rapamycin and cotylenin A, a novel differentiation-inducing agent, on human breast carcinoma MCF-7 cells and xenografts
Group I metabotropic glutamate receptors activate the p70S6 kinase via both mammalian target of Rapamycin (mTOR) and extracellular signal-regulated kinase (ERK …
Rapamycin and tumor growth: mechanisms behind its anticancer activity
inhibition of mammalian target of Rapamycin potentiates thrombin-induced intercellular adhesion molecule-1 expression by accelerating and stabilizing NF-κB …
Insulin stimulates postsynaptic density-95 protein translation via the phosphoinositide 3-kinase-Akt-mammalian target of Rapamycin signaling pathway
Modulation of insulin action by dietary proteins and amino acids: role of the mammalian target of Rapamycin nutrient sensing pathway
Rituximab in association with Rapamycin for post-transplant lymphoproliferative disease treatment
… macrophage colony-stimulating factor in neutrophils: cooperation of a MEK-related, THR421/SER424 kinase and a Rapamycin-sensitive, mTOR-related …
Rapamycin‐mediated induction of γ‐globin mRNA accumulation in human erythroid cells
Differing responses of Gat1 and Gln3 phosphorylation and localization to Rapamycin and methionine sulfoximine treatment in Saccharomyces cerevisiae
Mammalian target of Rapamycin inhibitors in combination with letrozole in breast cancer
… 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of Rapamycin signaling pathway and …
Rapamycin does not induce anergy but inhibits expansion and differentiation of alloreactive human T cells
Combination therapy of mycophenolate mofetil and Rapamycin in prevention of chronic renal allograft rejection in the rat1
Rapamycin worsens renal function and intratubular cast formation in protein overload nephropathy
Synergistic inhibition of human neuroblastoma-related angiogenesis by vinblastine and Rapamycin
Rapamycin inhibits human renal epithelial cell proliferation: effect on cyclin D3 mRNA expression and stability
… identified c-KIT receptor tyrosine kinase ITD in childhood AML induces ligand-independent growth and is responsive to a synergistic effect of imatinib and Rapamycin
Gln3 phosphorylation and intracellular localization in nutrient limitation and starvation differ from those generated by Rapamycin inhibition of Tor1/2 in …
Rapamycin preserves renal function compared with cyclosporine A after ischemia/reperfusion injury
… -inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of Rapamycin (mTOR) pathway is …
Superior T-cell suppression by Rapamycin and FK506 over Rapamycin and cyclosporine A because of abrogated cytotoxic T-lymphocyte induction, impaired memory …
Estrogen-induced activation of mammalian target of Rapamycin is mediated via tuberin and the small GTPase Ras homologue enriched in brain
… progesterone receptor expression in breast cancer cells via the phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin pathway: progesterone receptor as …
Acceleration of apoptosis in CD4+ CD8+ thymocytes by Rapamycin accompanied by increased CD4+ CD25+ T cells in the periphery1
Intracellular network of phosphatidylinositol 3‐kinase, mammalian target of the Rapamycin/70 kDa ribosomal S6 kinase 1, and mitogen‐activated protein kinases …
Interleukin-12-induced interferon-γ production by human peripheral blood T cells is regulated by mammalian target of Rapamycin (mTOR)
Pilot study of oral Rapamycin to prevent restenosis in patients undergoing coronary stent therapy: Argentina Single-Center Study (ORAR Trial)
… artery smooth muscle requires activation of phosphatidylinositol 3-kinase/serine-threonine protein kinase B/mammalian target of Rapamycin/p70 ribosomal S6 kinase …
Interferon α-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase/mammalian target of Rapamycin signaling pathway
ROS fusion tyrosine kinase activates a SH2 domain–containing phosphatase-2/phosphatidylinositol 3-Kinase/mammalian target of Rapamycin signaling axis to form …
Hyperactivation of mammalian target of Rapamycin (mTOR) signaling by a gain-of-function mutant of the Rheb GTPase
Oral Rapamycin inhibits growth of atherosclerotic plaque in apoE knock-out mice
Rapamycin, an mTOR inhibitor, disrupts triglyceride metabolism in guinea pigs
inhibition of insulin signaling and adipogenesis by Rapamycin: effect on phosphorylation of p70 S6 kinase vs eIF4E-BP1
Stable expression of small interfering RNA sensitizes TEL-PDGFβR to inhibition with imatinib or Rapamycin
Prolonged TCR/CD28 engagement drives IL-2-independent T cell clonal expansion through signaling mediated by the mammalian target of Rapamycin
Insulin-like growth factor I-mediated protection from Rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3′-kinase-Akt signaling …
Efficacy of polyphenon E, red ginseng, and Rapamycin on benzo (a) pyrene-induced lung tumorigenesis in A/J mice
… of mTOR as a novel bifunctional target in chronic myeloid leukemia: dissection of growth‐inhibitory and VEGF‐suppressive effects of Rapamycin in leukemic cells
Sustained activation of the mammalian target of Rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in …
Rapamycin antagonizes NF-κB nuclear translocation activated by TNF-α in primary vascular smooth muscle cells and enhances apoptosis
Rapamycin inhibits fibronectin-induced migration of the human arterial smooth muscle line (E47) through the mammalian target of Rapamycin
Rapamycin (sirolimus) as a steroid-sparing agent in dermatomyositis
Mammalian target of Rapamycin (mTOR) inhibitors
Glucose-stimulated DNA synthesis through mammalian target of Rapamycin (mTOR) is regulated by KATP channels: effects on cell cycle progression in rodent …
Targeting the AIB1 oncogene through mammalian target of Rapamycin inhibition in the mammary gland
Activation of mammalian target of Rapamycin in transformed B lymphocytes is nutrient dependent but independent of Akt, mitogen-activated protein kinase/extracellular …
Sirolimus-eluting stents remain superior to bare-metal stents at two years: medium-term results from the Rapamycin-Eluting Stent Evaluated at Rotterdam Cardiology …
Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a Rapamycin-and farnesylation-dependent manner
Rapamycin analogs with reduced systemic exposure
Mammalian target of Rapamycin and protein kinase A signaling mediate the cardiac transcriptional response to glutamine
Rapamycin decreases leukocyte migration in vivo and effectively reduces experimentally induced chronic colitis
Exercise‐induced alterations in extracellular signal‐regulated kinase 1/2 and mammalian target of Rapamycin (mTOR) signalling to regulatory mechanisms of mRNA …
Mechanistic insights into impaired dendritic cell function by Rapamycin: inhibition of Jak2/Stat4 signaling pathway
Cyclin D3 is down-regulated by Rapamycin in HER-2-overexpressing breast cancer cells
Rapamycin in children after liver transplantation
inhibition of the phosphatidylinositol 3-kinase/mammalian target of Rapamycin pathway in hematologic malignancies
Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal …
Activation of mammalian target of Rapamycin in postmenopausal ovarian endometriosis
Fatal infection after Rapamycin eluting coronary stent implantation
Effect of Rapamycin on the healing of the bile duct
Rapamycin in lung transplantation
Evidence for cyclin D3 as a novel target of Rapamycin in human T lymphocytes
Rapamycin in combination with cyclosporine or tacrolimus in liver, pancreas, and kidney transplantation
Lipase-catalyzed regioselective esterification of Rapamycin: synthesis of temsirolimus (CCI-779)
Role of oral Rapamycin to prevent restenosis in patients with de novo lesions undergoing coronary stenting: results of the Argentina single centre study (ORAR trial)
Structure-based design of AP23573, a phosphorus-containing analog of Rapamycin for anti-tumor therapy.
Rapamycin inhibits proliferation of human neuroblastoma cells without suppression of MycN
Rapamycin inhibits hTERT telomerase mRNA expression, independent of cell cycle arrest
… of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of Rapamycin (RAD001) offers improved …
Ex vivo Rapamycin generates donor Th2 cells that potently inhibit graft-versus-host disease and graft-versus-tumor effects via an IL-4-dependent mechanism
Studies investigating pretransplant donor-specific blood transfusion, Rapamycin, and the CD154-specific antibody IDEC-131 in a nonhuman primate model of skin …
Early renal benefit of Rapamycin combined with reduced calcineurin inhibitor dose in pediatric heart transplantation patients
inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung …
… Receptor Substrate-1 on Ser307 and Ser612 and Impairs the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin Insulin Biosynthetic Pathway in …
Insulin facilitation of muscle protein synthesis following resistance exercise in hindlimb-suspended rats is independent of a Rapamycin-sensitive pathway
The role of heme oxygenase 1 in Rapamycin-induced renal dysfunction after ischemia and reperfusion injury
Rapamycin inhibits human in stent restenosis vascular smooth muscle cells independently of pRB phosphorylation and p53
Synergistic growth inhibition by Iressa and Rapamycin is modulated by VHL mutations in renal cell carcinoma
Perturbed IFN-γ-Jak-signal transducers and activators of transcription signaling in tuberous sclerosis mouse models: synergistic effects of Rapamycin-IFN-γ treatment
Roles of phosphatidylinositol 3′-kinase and mammalian target of Rapamycin/p70 ribosomal protein S6 kinase in K-Ras-mediated transformation of intestinal epithelial …
EFFECT OF Rapamycin ON THE FATE OF P23H OPSIN ASSOCIATED WITH RETINITS PIGMENTOSA (AN AMERICAN OPHTHALMOLOGICAL SOCIETY …
Synergistic immunosuppressive effects of rosmarinic acid and Rapamycin in vitro and in vivo1
Long-term islet allograft survival in nonobese diabetic mice treated with tacrolimus, Rapamycin, and anti-interleukin-2 antibody1
Signaling interactions of Rapamycin combined with erlotinib in cervical carcinoma xenografts
Rapamycin inhibits release of tumor necrosis factor-[alpha] from human vascular smooth muscle cells
CD28 regulates the translation of Bcl-xL via the phosphatidylinositol 3-kinase/mammalian target of Rapamycin pathway
Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of Rapamycin/p70 S6K pathway
Mammalian target of Rapamycin is required for thrombopoietin‐induced proliferation of megakaryocyte progenitors
The fission yeast TOR proteins and the Rapamycin response: an unexpected tale
Safety and pharmacokinetics of ascending single doses of sirolimus (Rapamune®, Rapamycin) in pediatric patients with stable chronic renal failure undergoing …
Use of Rapamycin-impregnated stents in coronary arteries
In Vivo and In Vitro Effects of SAR 943, a Rapamycin Analogue, on Airway Inflammation and Remodeling
Farnesylthiosalicylic Acid Inhibits Mammalian Target of Rapamycin (mTOR) Activity Both in Cells and in Vitro by Promoting Dissociation of the mTOR-Raptor Complex
Regulation of microtubule-dependent protein transport by the TSC2/mammalian target of Rapamycin pathway
Pharmacokinetics of sirolimus (Rapamycin) in subjects with mild to moderate hepatic impairment
Low-dose radiation plus Rapamycin promotes long-term bone marrow chimerism
Rapamycin-coated expanded polytetrafluoroethylene bypass grafts exhibit decreased anastomotic neointimal hyperplasia in a porcine model
Anti–third-party veto CTLs overcome rejection of hematopoietic allografts: synergism with Rapamycin and BM cell dose
Combination of imatinib with Rapamycin or RAD001 acts synergistically only in Bcr-Abl-positive cells with moderate resistance to imatinib
Outcomes of using Firebird Rapamycin eluting stents in routine coronary intervention practice: one-year results from the pilot study of Firebird in China registry
Prolactin activates mammalian target-of-Rapamycin through phosphatidylinositol 3-kinase and stimulates phosphorylation of p70S6K and 4E-binding protein-1 …
Modulation of collagen and MMP-1 gene expression in fibroblasts by the immunosuppressive drug Rapamycin: A direct role as an antifibrotic agent?
Pmr1, a Golgi Ca2+/Mn2+-ATPase, is a regulator of the target of Rapamycin (TOR) signaling pathway in yeast
Rapamycin ameliorates experimental autoimmune myocarditis
First experience with Rapamycin-based immunosuppression to improve kidney function after heart transplantation
Three-year clinical follow-up of the unrestricted use of sirolimus-eluting stents as part of the Rapamycin-Eluting Stent Evaluated at Rotterdam Cardiology Hospital …
The mammalian target of Rapamycin-p70 ribosomal S6 kinase but not phosphatidylinositol 3-kinase-Akt signaling is responsible for fibroblast growth factor-9 …
Differential effects of Rapamycin, cyclosporine A, and FK506 on human coronary artery smooth muscle cell proliferation and signalling
Rapamycin causes activation of protein phosphatase-2A1 and nuclear translocation of PCNA in CD4+ T cells
Rapamycin: a new string to the antiproteinuric bow?
… the treatment of distal left main coronary artery disease in the drug-eluting stenting era. Clinical and angiographic insights into the Rapamycin-Eluting Stent Evaluated …
Mammalian target of Rapamycin inhibitors in sarcomas
Liposomal formulations of tacrolimus and Rapamycin increase graft survival and fiber outgrowth of dopaminergic grafts
Rapamycin treatment is associated with an increased apoptosis rate in experimental vein grafts
5‐HT stimulates eEF2 dephosphorylation in a Rapamycin‐sensitive manner in Aplysia neurites
Blockage of 2-deoxy-D-ribose-induced angiogenesis with Rapamycin counteracts a thymidine phosphorylase-based escape mechanism available for colon cancer …
Rapamycin in lung transplantation: preliminary results
Tsc1 haploinsufficiency without mammalian target of Rapamycin activation is sufficient for renal cyst formation in Tsc1+/− mice
Novel sulfur-containing Rapamycin analogs prepared by precursor-directed biosynthesis
Rapamycin inhibits Akt-mediated oncogenic transformation and tumor growth
Synergistic inhibition of human melanoma proliferation by combination treatment with B-Raf inhibitor BAY43-9006 and mTOR inhibitor Rapamycin
Akt and mammalian target of Rapamycin regulate separate systems of proteolysis in renal tubular cells
… with targeted therapies against epidermal growth factor receptor/human epidermal growth factor receptor 2 and mammalian target of Rapamycin in breast cancer
Mammalian target of Rapamycin regulates the growth of mammary epithelial cells through the inhibitor of deoxyribonucleic acid binding Id1 and their functional …
The effect of Rapamycin on the healing of the ureteric anastomosis and wound healing
Effect of SU11248 on gastrointestinal stromal tumor‐T1 cells: Enhancement of growth inhibition via inhibition of 3‐kinase/Akt/mammalian target of Rapamycin signaling
Combination of a Rapamycin analog (CCI‐779) and interferon‐γ is more effective than single agents in treating a mouse model of tuberous sclerosis complex
Overcoming T cell–mediated rejection of bone marrow allografts by T-regulatory cells: Synergism with veto cells and Rapamycin
Routine sirolimus eluting stent implantation for unselected in-stent restenosis: insights from the Rapamycin eluting stent evaluated at Rotterdam Cardiology Hospital …
Rapamycin inhibits liver growth during refeeding in rats via control of ribosomal protein translation but not cap-dependent translation initiation
… is regulated by phosphorylation and turnover of protein kinase C βII mediated by phosphatidylinositol 3-kinase-and mammalian target of Rapamycin …
Rapamycin rescue therapy in patients after kidney transplantation: first clinical experience
Heme oxygenase-1 mediates the protective effects of Rapamycin in monocrotaline-induced pulmonary hypertension
Successful treatment of a severe case of idiopathic pulmonary fibrosis with Rapamycin
Evaluation of Rapamycin chemical stability in volatile-organic solvents by HPLC
Characterization of the cloned full-length and a truncated human target of Rapamycin: activity, specificity, and enzyme inhibition as studied by a high capacity assay
Rapamycin reduces neointima formation during vascular injury.
Effects of aerobic exercise training on the protein kinase B (PKB)/mammalian target of Rapamycin (mTOR) signaling pathway in aged skeletal muscle
Effects of Rapamycin on the arterial inflammatory response in atherosclerotic plaques in Apo-E knockout mice
Effects of cyclosporin A and a Rapamycin derivative (SAR943) on chronic allergic inflammation in sensitized rats
Rapamycin induces a caspase‐independent cell death in human monocytes
Acute renal failure following kidney transplantation associated with myoglobinuria in patients treated with Rapamycin
Rapamycin inhibits cdk4 activation, p 21WAF1/CIP1 expression and G1‐phase progression in transformed mouse fibroblasts
Oral Rapamycin to prevent human coronary stent restenosis: a pilot study
A downstream kinase of the mammalian target of Rapamycin, p70S6K1, regulates human double minute 2 protein phosphorylation and stability
Rapamycin-resistant proliferation of CD8+ T cells correlates with p27kip1 down-regulation and bcl-xL induction, and is prevented by an inhibitor of …
In rat hepatocytes glucagon increases mammalian target of Rapamycin phosphorylation on serine 2448 but antagonizes the phosphorylation of its downstream …
Podospora anserina target of Rapamycin
Mammalian target of Rapamycin and 3-phosphatidylinositol 3-kinase pathway inhibition enhances growth inhibition of transforming growth factor-β1 in prostate cancer …
Actin cytoskeleton is required for nuclear accumulation of Gln3 in response to nitrogen limitation but not Rapamycin treatment in Saccharomyces cerevisiae
Post-Rapamycin proteinuria: incidence, evolution, and therapeutic handling at a single center
Farnesylthiosalicylic acid blocks mammalian target of Rapamycin signaling in breast cancer cells
Prevention of lethal acute GVHD with an agonistic CD28 antibody and Rapamycin
Effects of simian virus 40 large and small tumor antigens on mammalian target of Rapamycin signaling: small tumor antigen mediates hypophosphorylation of eIF4E …
Rapamycin‐sensitive induction of eukaryotic initiation factor 4F in regenerating mouse liver
Nutrient restriction differentially modulates the mammalian target of Rapamycin signaling and the ubiquitin-proteasome system in skeletal muscle of cows and their …
The Saccharomyces cerevisiae phosphatase activator RRD1 is required to modulate gene expression in response to Rapamycin exposure
Aortic eNOS expression and phosphorylation in Apo-E knockout mice: differing effects of Rapamycin and simvastatin
Mammalian target of Rapamycin (mTOR) inhibition in chronic lymphocytic B-cell leukemia: a new therapeutic option
… and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-γ is regulated by mammalian target of Rapamycin
The influence of the Rapamycin-derivate SDZ RAD on the healing of airway anastomoses
Cilomilast, tacrolimus and Rapamycin modulate dendritic cell function in the elicitation phase of allergic contact dermatitis
The impact of cyclosporine dose reduction with or without the addition of Rapamycin on functional, molecular, and histological markers of chronic allograft nephropathy
Role of endothelin-1 and nitric oxide bioavailability in transplant-related vascular injury: comparative effects of Rapamycin and cyclosporine
Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase 1 required for its mammalian target of Rapamycin-dependent …
Mammalian target of Rapamycin is a promising target for novel therapeutic strategy against cancer.
Effects of cyclosporin A, FK506 and Rapamycin on calcineurin phosphatase activity in mouse brain
Both mitogen activated protein kinase and the mammalian target of Rapamycin modulate the development of functional renal proximal tubules in matrigel
Activation of phosphatidylinositol 3-kinase, Akt, and mammalian target of Rapamycin is necessary for hypoxia-induced pulmonary artery adventitial fibroblast …
Effects of Rapamycin on cardiac and skeletal muscle contraction and crossbridge cycling
Frap, FKBP12 Rapamycin-associated protein, is a candidate gene for the plasmacytoma resistance locus Pctr2 and can act as a tumor suppressor gene
Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments in Tsc-deficient cells via inhibition of both Rapamycin-sensitive and-insensitive …
Modulation of translation‐initiation in CHO‐K1 cells by Rapamycin‐induced heterodimerization of engineered eIF4G fusion proteins
Rapamycin antagonizes cyclosporin A‐and tacrolimus (FK506)‐mediated augmentation of linker for activation of T cell expression in T cells
Activation of mammalian target of Rapamycin and the p70 S6 kinase by arsenic trioxide in BCR-ABL–expressing cells
Proteomic analysis of anti‐angiogenic effects by a combined treatment with vinblastine and Rapamycin in an endothelial cell line
The PCPH oncoprotein antagonizes the proapoptotic role of the mammalian target of Rapamycin in the response of normal fibroblasts to ionizing radiation
Sirolimus (Rapamycin) monotherapy prevents graft vascular disease in nonhuman primate recipients of orthotopic aortic allografts
Mammalian target of Rapamycin inhibitors in renal cell carcinoma: current status and future applications
Investigating mammalian target of Rapamycin inhibitors for their anticancer properties
Rapamycin treatment results in GATA factor-independent hyperphosphorylation of the proline utilization pathway activator in Saccharomyces cerevisiae
The Rapamycin derivative RAD inhibits mesangial cell migration through the CDK-inhibitor p27 Kip1
Combination therapy for treating breast cancer using antiestrogen, ERA-923, and the mammalian target of Rapamycin inhibitor, temsirolimus
Generating Rapamycin analogues by directed biosynthesis: starter acid substrate specificity of mono-substituted cyclohexane carboxylic acids
Electron microscopic and biochemical study of the effects of Rapamycin on glycogen autophagy in the newborn rat liver
… 4H-1-benzopyran-4-one) acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of Rapamycin (mTOR)-and non …
Rapamycin in patients with chronic renal allograft dysfunction
Regulation of the phosphatidylinositol 3-kinase, Akt/protein kinase B, FRAP/mammalian target of Rapamycin, and ribosomal S6 kinase 1 signaling pathways …
… of metallothionein rescues chronic alcohol intake-induced cardiomyocyte dysfunction: role of Akt, mammalian target of Rapamycin and ribosomal p70s6 kinase
Rapamycin inhibits E2F-dependent expression of minichromosome maintenance proteins in vascular smooth muscle cells
Targeting metastatic leiomyosarcoma by Rapamycin plus gemcitabine: an intriguing clinical observation
Vanadate and Rapamycin synergistically enhance insulin-stimulated glucose uptake
Rapamycin control of transgene expression from a single AAV vector in mouse salivary glands
Cutaneous leukocytoclastic vasculitis in a patient with myelodysplatic syndrome after therapy with the Rapamycin analogue everlimus: Case report and review of the …
Determining sensitivity to Rapamycin and its analogues in breast cancer patients
Rapamycin pre‐treatment preserves viability, ATP level and catabolic capacity during carbon starvation of Saccharomyces cerevisiae
Rapamycin and FK506 reduce skeletal muscle voltage sensor expression and function
Extracellular ATP-induced proliferation of adventitial fibroblasts requires phosphoinositide 3-kinase, Akt, mammalian target of Rapamycin, and p70 S6 kinase …
The mTOR pathway in estrogen response: A potential for combining the Rapamycin derivative RAD001 with the aromatase inhibitor Letrozole (Femara®) in breast …
inhibition of mammalian target of Rapamycin modulates expression of adhesion molecules in endothelial cells
SUMO modification through Rapamycin-mediated heterodimerization reveals a dual role for Ubc9 in targeting RanGAP1 to nuclear pore complexes
Cyclosporine and Rapamycin act in a synergistic and dose-dependent manner in a model of immunosuppressant-induced kidney damage
Current Data with Mammalian Target of Rapamycin Inhibitors in Advanced Renal Cell Carcinoma
Novel site‐specific systemic delivery of Rapamycin with perfluorobutane gas microbubble carrier reduced neointimal formation in a porcine coronary restenosis model
The phosphatase subunit tap42 functions independently of target of Rapamycin to regulate cell division and survival in Drosophila
Rapamycin control of exocrine protein levels in saliva after adenoviral vector-mediated gene transfer
Farnesyltransferase inhibitors and Rapamycin in the treatment of multiple myeloma
RACK1 mRNA translation is regulated via a Rapamycin-sensitive pathway and coordinated with ribosomal protein synthesis
Mammalian target of Rapamycin promotes vincristine resistance through multiple mechanisms independent of maintained glycolytic rate
Bone morphogenetic protein-2–induced transformation involves the activation of mammalian target of Rapamycin
Rapamycin prolongs susceptibility of responding T cells to tolerance induction by CD8+ veto cells
Current status of mammalian target of Rapamycin inhibitors in lung cancer
Rapamycin inhibits vascular remodeling in an experimental model of allograft vasculopathy and attenuates associated changes in fibrosis-associated gene …
Rapamycin and dendritic cells: keep on movin’
Involvement of c-Jun NH2 terminal kinase and p38MAPK in Rapamycin-mediated inhibition of neointimal formation in rat carotid arteries
Involvement of the VDE homing endonuclease and Rapamycin in regulation of the Saccharomyces cerevisiae GSH11 gene encoding the high affinity …
Immunomodulatory effects of combination of pooled human gammaglobulin and Rapamycin on cell proliferation and apoptosis in the mixed lymphocyte reaction
Six-month intravascular ultrasound follow-up of coronary bifurcation lesions treated with Rapamycin-eluting stents: technical considerations
Trace analysis of Rapamycin in human blood by micellar electrokinetic chromatography
Insulin-like growth factor binding protein-6 and CCI-779, an ester analogue of Rapamycin, additively inhibit rhabdomyosarcoma growth
Differential translation of TOP mRNAs in Rapamycin-treated human B lymphocytes
Rapamycin for androgen-independent prostrate cancer (AIPC)
Rapamycin for cardiac transplant rejection and vasculopathy: one stone, two birds?
Sirolimus and everolimus: inhibitors of mammalian target of Rapamycin in liver transplantation
Rapamycin inhibits choroidal neovascularization
Deletion of HOG1 leads to Osmosensitivity in starvation-induced, but not Rapamycin-dependent Atg8 degradation and proteolysis: Further evidence for different …
Structure and function of mammalian target of Rapamycin [J]
Comparison of Rapamycin and paclitaxel eluting stent in patients with multi-vessel coronary disease
Retracted: Rapamycin Attenuates Liver Graft Injury in Cirrhotic Recipient—The Significance of Down‐Regulation of Rho‐ROCK‐VEGF Pathway
Pharmacokinetics of Rapamycin-eluting stents in miniswine coronary model.
Combination therapy with sirolimus (Rapamycin) and tacrolimus (FK-506) in treatment of refractory minimal change nephropathy, a clinical case report
Combination of the mammalian target of Rapamycin (mTOR) inhibitor everolimus (E) with the insulin like growth factor-1-receptor (IGF-1-R) inhibitor NVP-AEW-541: A …
Rapamycin and chronic lung rejection
Synergistic suppression of rat neointimal hyperplasia by Rapamycin and imatinib mesylate: implications for the prevention of accelerated arteriosclerosis
An intramolecular ionic hydrogen bond stabilizes a cis amide bond rotamer of a ring‐opened Rapamycin‐degradation product
The effect of combined Rapamycin/cyclosporine on the changes in pro-fibrotic gene expression that occur during the development of allograft vasculopathy in rats …
Modulation of tissue factor expression by Rapamycin and FK-506 in lipopolysaccharide-stimulated human mononuclear cells and serum-stimulated aortic smooth …
Effect of Rapamycin on hepatic osteodystrophy in rats with portasystemic shunting
Preclinical rationale for therapeutic targeting of mTOR by CC-I779 and Rapamycin in Hodgkin lymphoma
Potential role of mammalian target of Rapamycin inhibitors in breast cancer therapy
Altered centrosomes in ataxia‐telangiectasia cells and Rapamycin‐treated Chinese hamster cells
Determination of Rapamycin: quantification of the sodiated species by an ion trap mass spectrometer as an alternative to the ammoniated complex analysis by triple …
Nutritional studies on the growth of the Rapamycin-producing Streptomyces hygroscopicus
A novel technique for on‐capillary preconcentration of anionic compounds applied to the trace analysis of Rapamycin in human blood by capillary electrophoresis
… of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib in combination with the mammalian target of Rapamycin (mTOR) inhibitor everolimus …
Glucose-induced binding of the polypyrimidine tract-binding protein (PTB) to the 3′-untranslated region of the insulin mRNA (ins-PRS) is inhibited by Rapamycin
A phase I trial of gefitinib (ZD1839) plus Rapamycin for patients with recurrent malignant glioma
Clinical use of Rapamycin in renal allograft recipients identifies its relevant toxicity profile and raises unsolved questions: a single-center experience
Lung toxicity induced by Rapamycin
Countervailing effects of Rapamycin (sirolimus) on nuclear factor-κB activities in neointimal and medial smooth muscle cells
Dose-dependent inhibition of myointimal hyperplasia by orally administered Rapamycin
Association of Rapamycin and co-stimulation blockade using anti-B7 antibodies in renal allotransplantation in baboons
inhibition of growth and metastasis of hepatocellular carcinoma by Rapamycin: experiment with mice
Cyclosporine A, FK-506, 40-0-[2-hydroxyethyl] Rapamycin and mycophenolate mofetil inhibit proliferation of human intrahepatic biliary epithelial cells in vitro
Rapamycin inhibits platelet-derived growth factor-induced collagen, but not fibronectin, synthesis in rat mesangial cells
A combination of anergic cells’ adoptive transfer and Rapamycin therapy prolongs cardiac allograft survival in mice
Local application of Rapamycin inhibiting restenosis in experimental vein graft
Negative regulation of interleukin-12 production by a Rapamycin-sensitive signaling pathway: a brief communication
Rapamycin-based rescue therapy after chronic rejection in a pediatric liver transplant patient
Altered trafficking of CD8+ memory T cells after implantation of Rapamycin-eluting stents in patients with coronary artery disease
Rapamycin at six years can exhibit normal renal function without proteinuria or neoplasia after renal transplantation. A single-center experience
Expression of placental mammalian target of Rapamycin (mTOR) is altered in relation to fetal growth and mTOR regulates leucine transport
Regulation of hepatic insulin-like growth factor-binding protein-1 gene expression by insulin: central role for mammalian target of Rapamycin independent of forkhead …
Rapamycin–a Potential Mechanistically Targeted Therapeutic for Juvenile Myelomonocytic Leukemia.
In vivo and in vitro effect of CCI-779 a Rapamycin analogue on HNSCC.
Pathologic assessment of cardiomyocytes in heart transplant recipients treated with Rapamycin or cyclosporine
Pharmacodynamic-guided, modified continuous reassessment method (mCRM)-based, dose finding study of Rapamycin in adult patients with solid tumors
Pharmacokinetics and safety of ABT-578, a sirolimus (Rapamycin) analogue, after single intravenous bolus injection in healthy male volunteers
Rapamycin Inhibits Retinal and Choroidal Neovascularization in Mice
In Vitro and In Vivo Antileukemic Effects of the mTOR-Targeting Drug Rapamycin in Patients with Imatinib-Resistant CML.
Dual effects of Rapamycin on immuno-suppression and tumor inhibition
Rapamycin inhibits the pathogenesis of posterior capsule opacification: experimental study on rabbit [J]
Sphingosine-1-phosphate–induced smooth muscle cell migration involves the mammalian target of Rapamycin
Phase I study of gefitinib and Rapamycin in patients with recurrent or progressive glioblastoma (Gbm)
Rapamycin has no effect on fibrosis-associated gene expression or extracellular matrix accumulation when administered to animals with established or early …
Effect of Rapamycin on cytokine profile in kidney transplant recipients treated with triple drug therapy
Rapamycin as rescue therapy in a patient supported by biventricular assist device to heart transplantation with consecutive ongoing rejection
Effect of Rapamycin on Phenotype of Vascular Smooth Muscle Cell and Arterial Intimal Hyperplasia Post Balloon Injury in Rat [J]
Rapamycin plays a new role as differentiator of vascular smooth muscle phenotype. Focus on “The mTOR/p70 S6K1 pathway regulates vascular smooth muscle …
… -up of the unrestricted use of the sirolimus-eluting stent compared to the use of a standard bare metal stent as part of the Rapamycin-Eluting-Stent Evaluated at …
Observations on quadruple immunosuppression maintenance therapy using Rapamycin, low-dose cyclosporine, mycophenolate mofetil, and prednisone following …
Mode of action of FK506 and Rapamycin
Phase I study of Rapamycin (R) in combination with CYP3A4 modifier, ketoconazole (K), in patients with advanced malignancies
Renal calcium handling after Rapamycin conversion in chronic allograft dysfunction
Studies towards the synthesis of Rapamycin: Regiocontrol in the addition of carbanions to enantiomerically pure epoxides and the formation of a highly substituted …
Rapamycin.
Thrombosis caused by active Rapamycin stents
Effect of Rapamycin and dexamethasone on differentiation and maturation of murine bone marrow-derived dendritic cells
Comparison of Rapamycin versus FK506 on expression of cytoprotective genes in the rat kidney allografts undergoing chronic allograft nephropathy
Why inhibitors of mammalian target of Rapamycin will be important in organ transplantation
Stent release of a Rapamycin analogue: tissue pharmacokinetics of rapid versus delayed release
Rapamycin: from the laboratory to the treatment of patients’ arteries
Experimental study on the effects of Rapamycin in prevention of rat corneal allograft rejection
Rapamycin overcomes multidrug resistance (MDR) mediated by P-glycoprotein (Pgp), Multidrug Resistance Protein-1 (MRP-1), Breast Cancer Resistance Protein …
Complete assignments of the 1H and 13C resonances of 40‐epi‐(N1‐tetrazolyl)‐Rapamycin and revised 13C assignments for Rapamycin
The Combination of the mTOR Inhibitor Rapamycin and Proteasome Inhibitor Bortezomib Is Synergistic In Vitro in Multiple Myeloma.
Oral Rapamycin for the prevention of in-stent restenosis
Rapamycin Enhances the Cytotoxicity of Bortezomib and Rituximab on Mantle Cell Lymphoma (MCL) Cell Lines.
Surviving Rapamycin
Lack of effect of Rapamycin in anti-CCP antibody production in a rheumatoid arthritis kidney allograft recipient
Mammalian target of Rapamycin inhibitors in transplantation: novel immunosuppressive strategies with sirolimus
Efficacy of Early Use of Rapamycin for Patients after Renal Transplantation and the Complications
1139-52 Biolimus A9: a new generation Rapamycin analogue inhibits intimal hyperplasia in a porcine model
Rapamycin eluting stents
Mammalian target of Rapamycin (mTOR) as a target in human breast cancer cells that have acquired resistance to aromatase inhibitor letrozole
Rapamycin: sc-3504
Investigation of Rapamycin and Rapamycin metabolites.
Inhibitors of mammalian target of Rapamycin: mechanism of action explains efficacy and toxicity
Rapamycin even when combined with cyclosporine attenuates tumor growth but does not induce regression of established walker sarcomas
Sirolimus (Rapamycin) reduces the incidence of acute rejection episodes in renal transplantation: An initial experience in Taiwan
Clinic application of Rapamycin-eluting stent for coronary heart disease [J]
Intravitreal toxicity of Rapamycin
Two-year experience with Rapamycin in kidney transplantation
Safety and efficacy of sirolimus-eluting stent (cypher) in acute myocardial infarction: A substudy of the Rapamycin-Eluting Stent Evaluation at Rotterdam Cardiology …
Sirolimus-eluting stents for treatment of in-stent restenosis in the real world: Preliminary results from the Rapamycin-Eluting Stent Evaluated at Rotterdam Cardiology …
Rapamycin Combined with Cyclosporine in the Prevention of Acute Renal Allograft Rejection: Randomized Prospective Control Study
Adverse effects of local or systemic application of Rapamycin for the prevention of neointimal hyperplasia
Effect of combined regimen of Rapamycin and Cyclosporine on renal transplant recipients [J]
Short-term Rapamycin for inhibition of neointima formation after balloon-mediated aortic injury in rats: is there a window of opportunity for systemic prophylaxis of …
Pilot study with oral Rapamycin in patients undergoing stenting in coronary arteries: Buenos Aires experience (ORAR trial)
CONTRASTING EFFECTS OF CYCLOSPORIN AND Rapamycin IN DE NOVO GENERATION OF ALLOANTIGEN-STIMULATED REGULATORY T CELLS.
Combination of the mTOR inhibitor Rapamycin and HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17AAG) inhibits proliferation and induces apoptosis …
Effects of Rapamycin-treated HSP60-pulsed dendritic cells on the progression of the atherosclerotic plaque in mice [J]
Curcumin disrupts the complexes of the mammalian target of Rapamycin
Review on Rapamycin as a potential therapeutic agent against neurodegenerative disease
TOR (target of Rapamycin)-mediated regulation of translation
Comparison of Different Therapies Of CYPHERTM Stent For Patients with Bifurcated Lesion Using Rapamycin
Experimental study of effect of Rapamycin on proliferation of rat aortic smooth muscle cells
Influence of CTLA4Ig combined with Rapamycin on the survival of renal allografts in rats [J]
Local applied slow-releasing Rapamycin inhibits neointima hyperplasia in vein graft
Rapamycin PREVENTS INTERSTITIAL FIBROSIS IN RENAL ALLOGRAFTS THROUGH DECREASING ANGIOGENESIS AND INFLAMMATION.
… Regulatory (CD4+ CD25+ CD127LowFOXP3+) Cells to High Purity by Inhibiting Expansion of CD4+ CD25+ CD127HighFOXP3-Conventional T Cells with Rapamycin …
Rapamycin impairs the healing of the ureteric anastomosis
Effects of Rapamycin on the early development of zebrafish (Danio rerio)
The combination of arsenic trioxide and Rapamycin has potent inhibitory effects on acute myeloid leukemia (AML) cells
avb3-integrin-targeted paramagnetic nanoparticles deliver Rapamycin into the vascular wall and inhibit stenosis following balloon injury
Treatment of lesions with a high risk of stenosis. comparative study in 300 patients of Rapamycin-and paclitaxel-eluting polymer-based stents, and bare metal stents
Rapamycin Has Biological Activity in a Subset of Patients with Myelodysplastic Syndrome-Results of a Phase I/II Trial.
Effect of Mycophenolic Acid and Rapamycin on the Proliferation of Glomerular Mesangial Cell of Rat
Regulation of the mammalian target of Rapamycin complex 2 (mTORC2)
Rapamycin NOT CYCLOSPORINE INDUCES REGULATORY CD8+ FOXP3+ CELLS.
Comparison of the effects of Rapamycin-eluting stent implantation and coronary artery bypass grafting in treatment of patients with multi-vessel coronary disease
Glucose-stimulated DNA Synthesis through Mammalian Target of Rapamycin (mTOR) Is Regulated by KATP Channels
Subretinal sustained delivery of Rapamycin in the rabbit eye
Constitutive Activation of Akt and mTOR by Flt3 Internal Tandem Duplications Mediates Myeloid Leukemogenesis and Can Be Inhibited by Rapamycin.
Long-term clinical efficiency of endovascular treatment using Cypher Rapamycin-eluting stents in patients with coronary heart disease
DOES Rapamycin EFFECT WOUND HEALING?
Successful retransplantation using Rapamycin in a patient with previous calcineurin inhibitor-induced posterior leukoencephalopathy syndrome.
Rapamycin inhibits the development of gallbladder adenocarcinoma in BK5. erbB2 transgenic mice
Rapamycin disruption of mTOR-mLST8-raptor complex inhibits cell motility
In vitro Rapamycin and costimulation generates Th1/Tc1 or Th2/Tc2 central memory effectors: Differential regulation by in vivo Rapamycin after allogeneic BMT
Effect of combination of curcumin and Rapamycin on proliferation of rat glomerular mesangial cells
Signaling by Target of Rapamycin Proteins
Distinct mechanisms by which low and high Rapamycin doses raise plasma triglycerides in guinea pigs
Everolimus: a classical mammalian target of Rapamycin inhibitor?
Murine Ultrasonography Confirms That Rapamycin Is Effective Against Autoimmune Lymphoproliferative Syndrome (ALPS).
STABILIZATION OF LONG-TERM PEDIATRIC RENAL ALLOGRAFTS WITH Rapamycin.
A tissue selective Rapamycin analog inhibits MDA-MB-231 breast cancer cell-induced osteolytic bone metastases in nude mice
Rapamycin throws a master switch.
Rapamycin-CUSTOMIZED DENDRITIC CELLS ARE RESISTANT TO MATURATION INDUCED BY CD40 LIGATION—A CONDITION PIVOTAL TO THEIR …
USE OF Rapamycin IN CHILDREN POST LIVER TRANSPLANTATION
Mammalian Target of Rapamycin inhibition Synergistically Increases Cytotoxicity of Vinorelbine in Breast Cancer Cells.
The role of caspase-3 in Rapamycin-induced apoptosis of hepatocellular carcinoma BEL-7402 cells
Enhanced Killing of Chronic Myelogenous Leukemia Cells by Rapamycin and Imatinib Is Associated with Differential inhibition of 4E-BP1 and eIF4E Phosphorylation …
Rapamycin Induces Balb/C Murine CD4+CD25+Foxp3+ T Cells Proliferations.
Effect of locally administered Rapamycin and cyclosporin A on penetrating keratoplasty rejection rat model
Curcumin inhibits the mammalian target of Rapamycin-mediated signaling pathways
Bone-targeted Rapamycin analogs inhibit osteolysis and tumor growth in a PC-3-GFP intratibial bone cancer model in nude mice
The expression of mammalian target of Rapamycin and its substrates in autogenous vein graft in rats
Effects of Rapamycin on Notch1/Jagged1 signal pathway and the expression of fibronectin in TGF-β, induced rat renal intertitial fibroblasts [J]
The mTOR Inhibitor Rapamycin Inhibits Drug Transport in Multidrug Resistant Cell Lines and in Acute Myeloid Leukemia (AML) Cells.
Effect of Rapamycin on Corneal Neovascularization
THE EFFECT OF Rapamycin ON BILE DUCT HEALING
Safety and efficacy comparison between Rapamycin-eluting stent with biodegradable polymer or permanent polymer in patients with coronary artery disease
Rapamycin added to human CD25+ cell cultures activated through CD3/CD28 enriches for CD4+ CD25+ CD27+ Foxp3+ regulatory T cells
Effect of Mycophenolic Acid and Rapamycin on the Proliferation and Collagen Synthesis of the Vascular Smooth Muscle Cell of Rat
Two-year experience with Rapamycin in kidney transplantation
Effects of Rapamycin on the function of human dendritic cells
Effects of Rapamycin on Rho-kinase and p27 mRNA expressions in a porcine coronary intimal proliferation model induced by interleukin-1beta
IN CONTRAST TO CYCLOSPORIN, Rapamycin SPARES FOXP3+ CD4+ T-CELLS IN VIVO.
Rapamycin THERAPY IN PANCREAS ALLOGRAFT RECIPIENTS
Sustained Rapamycin drug delivery system in prevention of high risk corneal allograft rejection and neovascularization in rabbits
The role of GSK3β in Rapamycin-mediated cell cycle regulation
Rapamycin Treatment Results in GATA
Possible molecular target therapy with Rapamycin in MDS
Blocking mTOR by Rapamycin reduces HIF-1α function in human gastric cancer cells in vitro and inhibits angiogenesis and tumor growth in vivo
Influence of CTLA4Ig combined with Rapamycin on the survival of renal allografts in rats
Combination therapy of bevacizumab with Rapamycin in antitumor activity.
EVALUATION OF APOPTOSIS IN PERIPHERAL HUMAN LYMPHOCYTES EXPOSED TO Rapamycin.
… IN CHRONIC ALLOGRAFT NEPHROPATHY (CAN) FOLLOWING CALCINEURIN INHIBITORS (CNI) WITHDRAWAL AND CONVERSION TO Rapamycin.
Application of Rapamycin in the patients with liver injury following renal transplantation: a report of 7 cases
Establishment of a Rapamycin-resistant cell line that retains sensitivity to PI3 kinase inhibitors.
mTOR (mammalian target of Rapamycin) inhibition with RAD001 induces cell cycle arrest in diffuse large B cell lymphoma (DLBCL) cells and sensitizes DLBCL cells to …
A Novel Serum-Stable Micelle System for Controlled Release of Rapamycin
The effects of Rapamycin for the chole-sterol rabbits after balloon injury
Effect of New Immunosuppressant-Rapamycin on One-Way Mixed Lymphocyte Culture
inhibition of repopulation is not a determining factor for the radiosensitizing effects of Rapamycin
Antitumor efficacy of Rapamycin derivertive RAD001 in human ovarian cancer
Dendritic cells, Rapamycin and transplant tolerance
Troglitazone Exerts a Cell-Dependent Effect on the Extracellular Secretion of VEGF165 Independently from the Rapamycin Sensitivity or the Level of eIF4E …
Rapamycin inhibited the growth of hepatocellular carcinoma in nude mice
Rapamycin-Eluting Stents for the Treatment of In-Stent Restenosis
Effect of Rapamycin on Renal Ischemia Reperfusion Injury
Mutant type glutathione S-transferase theta 1 gene homologue to mTOR in myelodysplastic syndrome: possible clinical application of Rapamycin
A RARE CASE OF Rapamycin INDUCED SECRETORY DIARRHEA IN A LIVER TRANSPLANT PATIENT: 544
Clinical application of domestic Rapamycin-eluting stents in coronary heart disease patients
The Studies of Antitumor Effect of Rapamycin on Human Hepatocellular Carcinoma BEL-7402 Cells in vitro
Investigation of the Function and Regulatory Mechanisms of the Mammalian Target of Rapamycin
New progress of Rapamycin in prevention and treatment of chronic allograft nephropathy
Mammalian Target of Rapamycin (mTOR)
Rapamycin treatment during fractionated radiotherapy causes cell death in 3D culture
18F-Labeled analog of Rapamycin for PET imaging
Rapamycin-SENSITTVE SIGNAL TRANSDUCTION PATHWAYS AND THE CONTROL OF ADIPOGENESIS
Therapeutic effect of Rapamycin in the treatment of malignancies in recipients after kidney transplantation
Sirolimus (Rapamycin) impairs renal function
Rapamycin INHIBITS NK CELL FUNCTION
… WITH THYMOGLOBULIN/ZENAPAX INDUCTION, TACROLIMUS AND STEROID MAINTENANCE, COMPARING Rapamycin WITH MYCOPHENOLATE MOFETIL …
Rapamycin modifies the vascular tone of rat isolated aortas
Rapamycin-INDUCED PROTEINURIA: INCIDENCE, OUTCOME AND THERAPEUTIC HANDLING.
Prolonged survival of renal allografts with domestic Rapamycin in rats [J]
… FUNCTIONS OF REGULATORY T CELLS, LEADING, IN CONJUNCTION WITH A BRIEF SUB-THERAPEUTIC COURSE OF Rapamycin, TO ROBUST, DONOR …
Clinical Benefits of Rapamycin-Eluting Stent Implantation in Patients With Acute Coronary Syndromes
The role of phosphorylation in the regulation of the mammalian target of Rapamycin.
The clinical effect of homemade Rapamycin-eluting stent on acute myocardial infarction
Regulation of skeletal muscle differentiation by a Rapamycin-sensitive signaling pathway
THE MAMMALIAN TARGET OF Rapamycin (mTOR) AS A TARGET FOR CANCER CHEMOTHERAPY
Combination therapy targeting hypoxia inducible factor-α (HIF-1 α) and Tissue Factor (TF) by the mTOR inhibitor Rapamycin and the histone deacetylase inhibitor …
Rapamycin is efficacious against gliomas and acts as an anti-VEGF and anti-invasion agent
DIFFERENT FUNCTIONAL, HISTOLOGICAL AND INMUNOHISTOCHEMICAL PATTERNS INDUCED BY THE ASSOCIATION OF Rapamycin WITH FK506 OR …
Orally Administered Rapamycin Can Inhibit Myointimal Hyperplasia: Should It Be Used?
Effects of Rapamycin-eluted stent on platelet function in patients with coronary heart disease
Regulation of the GATA-type transcription factor Gln3p by the target of Rapamycin protein (TOR).
Combination of Rapamycin and somatostatin analogues for the treatment of nonfunctioning pituitary tumors
The experimental study on the effects of Rapamycin and statin on chronic transplant vasculopathy
Rapamycin targets Cyclin/Cdk/p21/PCNA complexes and Cyclin D1 reverses Rapamycin action by stabilizing these complexes
Rapamycin conversion for immunosuppressive therapy in the setting of renal insufficiency in patients with heart transplantation: pilot observations
Inhibitory Effect of Rapamycin on Corneal Neovascularization induced by Angiogenin in Rabbits
NURSING IMPLICATIONS REGARDING THE MANAGEMENT OF SIDE EFFECTS IN A PHASE I STUDY USING GEFITINIB WITH Rapamycin.
Clinical Contrast Investigation of Rapamycin Eluting Stent between Chinese Making and Imported
The role of mammalian target of Rapamycin (mTOR) in a rat model of autoimmune myocarditis
Effect of Rapamycin on Mouse Chronic Lymphocytic Leukemia and the Development of Nonhematopoietic Malignancies in Em-TCL1 Transgenic Mice
Overview of Therapeutic Potential of Rapamycin for Coronary Artery Diseases in the Era of the Drug-Eluting Stent
Rapamycin-Sensitive Signal Transduction Pathways and the Control of Adipogenesis
Rapamycin for Cardiac Transplant Rejection and Vasculopathy
Rapamycin synergistically enhances the cytotoxicity of paclitaxel in breast cancer cells
Oral Rapamycin attenuates progression of atherosclerotic plaque in ApoE knockout mice
Clinical Research of Rapamycin-Eluting Stent in Treatment of Multi-Vessel Coronary Disease
Rapamycin inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells
Biocompatibility of Rapamycin-Batroxobin Eluting Stent in Porcine Coronary Artery
Effect of Rapamycin on anti-HLA donor antibody formation in patients with transplant coronary artery disease
Combination of the mTOR Inhibitor Rapamycin and Revlimid™(CC-5013) Has Synergistic Activity in Multiple Myeloma (MM).
Characterization of the FKBP·Rapamycin·FRB Ternary Complex [J. Am. Chem. Soc. 2005, 127, 4715−4721].
Is there a role for oral Rapamycin in restenosis prevention after bare-metal stent implantation?
Isolation and Genetic Analysis of Rapamycin-sensitive mutants in Aspergillus nidulans.
Overexpression of the Bad mutant (S112A) partially disrupts the ability of IGF-I to protect cells from Rapamycin-induced apoptosis
One year effect of Rapamycin eluting stent in patients with coronary heart disease
The role of mammalian target of Rapamycin (mTOR) in insulin resistance
Rapamycin AND SANGLIFEHRIN A CAN INHIBIT INTERLEUKIN-18 PRODUCTION FROM DENDRITIC CELLS IN VITRO AND IN VIVO.
MRI detection of Rapamycin and AP-Cav therapeutic rescue from endothelial over expression of Akt in transgenic mice
SENSITIVITY OF HUMAN METASTATIC MELANOMA CELLS TO THE ESTER ANALOG OF Rapamycin, CCI-779
Synergistic growth inhibition by Iressa and Rapamycin in Renal Cell Carcinoma (RCC) with wild-type VHL
Six-month results of a biodegradable polymer and Rapamycin-coating stent for coronary artery disease
The mTOR inhibitor, Rapamycin, inhibits growth of Ewing’s sarcoma in vitro and in vivo
EEEICACY AND SAFETY OF Rapamycin-BASED IMMUNOSUPPRESSION REGIMEN WITH OR WITHOUT CSA IN RENAL TRANSPLANTATION: A SYSTEMATIC …
Rapamycin Inhibits Rabbit Corneal Neovascularization Induced by Angiogenin
Preclinical analysis of Rapamycin plus EGFR or MEK1/2 inhibitors in renal cell carcinoma (RCC)
Effect of Rapamycin (RPM) on interleukin-10 gene expression in rats with postburn Staphylococcus aureus sepsis
Effect of Rapamycin on mouse CLL and development of non-hematopoietic malignancies in Eμ-TCL1 transgenic mice
Effect of isoflavones alone and in combination with Rapamycin on mTOR pathway in human glioblastoma cells (U87).
Rapamycin INHIBITS THE SPONTANEOUS FORMATION OF DE NOVO CANCER IN P53 KNOCKOUT MICE.
Urokinase-induced smooth muscle cell migration involves the mammalian target of Rapamycin
Importance of mammalian target of Rapamycin inhibitors in the prevention of cardiac allograft vasculopathy
Rapamycin enhances the number and function of alloantigen-induced human CD103+CD8+ regulatory T cells in vitro
Clinical contrast investigation of Rapamycin eluting stent between Chinese making and imported in the treatment of coronary artery disease
Rapamycin inhibits activation of STAT3 in renal tissue of IgA nephropathy rats
The mTOR inhibitor Rapamycin inhibits proadhesive activity of arterial intimal smooth muscle cells
Identification of a highly effective Rapamycin schedule that markedly reduces the size, multiplicity and phenotypic progression of tobacco carcinogen-induced murine …
Mammals Target Protein of Rapamycin (mTOR) Expression in Adult Acute Myeloid Leukemia Patients
A Randomized Comparison Between Paclitaxel-Eluting Stents and Rapamycin-Eluting Stents for Patients With Coronary Artery Diseases
Silencing mTOR signal by small interfering RNA enhances Rapamycin-induced autophagy in malignant glioma cells.
CYCLOSPORINE AND Rapamycin ACT IN A SYNERGISTIC AND DOSE-DEPENDENT MANNER IN A MODEL OF IMMUNOSUPPRESSANT-INDUCED KIDNEY …
The role of the mammalian target of Rapamycin (mTOR) in long term potentiation
Nursing intervention of chronic renal diseases patients orally taking Rapamycin after underwent kidney transplantation [J]
The effect of Rapamycin after cyclosporin dose reduction on chronic allograft nephropathy
The Saccharomyces Cerevisiae Phosphatase Activator YPTPA1/RRD1 is Required to Modulate Gene Expression in Response to Rapamycin Exposure
COMBINATION OF Rapamycin PLUS MUTANT TGF-b/Fc TO INDUCE IMMUNE TOLERANCE.
Effect of Akt (PKB) on the activity of mammalian target of Rapamycin (mTOR)
Effect of Rapamycin Eluting Stent on Level of C-reactive Protein in Patients with Acute Coronary Syndrome After Angioplasty [J]
PI3K and mTOR signalling pathways: perspectives for Rapamycin and its derivatives as antineoplastic targeted therapies
Effectiveness and safety of Rapamycin-based immunosuppression regimens on preserving or withdrawing CsA in renal transplantation: a systematic review
The modulation of neointimal proliferation and p27 kip expression after implanting Rapamycin-eluting stents in the porcine coronary model
Different released Rapamycin eluting stents to reduce in-stent neointimal hyperplasia in a porcine coronary model
CHIMERISM PLAYS AN ACTIVE ROLE IN TRANSPLANTATION TOLERANCE INDUCED BY ALS, Rapamycin AND DONOR BONE MARROW INFUSION
Effect of Biodegradable Rapamycin-Eluting Stent on Neointimal Proliferation in Porcine Coronary Artery Model
Rapamycin INHIBITS IL-10 INDUCTION BY LATENT MEMBRANE PROTEIN 1 OF EPSTEIN BARR VIRUS.
Editorial [Hot Topic: Mammalian Target of Rapamycin as a Therapeutic Target in Leukemia (Executive Editors: Francis J. Giles/Maher Albitar)]
A Gene Expression Connectivity Map Identifies Rapamycin as a Glucocorticoid Resistance Reversal Agent in Lymphoblastic Leukemia.
Rapamycin-sensitive TOR signaling regulates intestinal growth and morphogenesis in zebrafish
TARGET OF Rapamycin (TOR) MEDIATES THE ENDODERM-INTESTINE TRANSITION IN ZEBRAFISH: 68
Lactic-co-glycolic acid polymer with Rapamycin coated stent reduces neo-intimal formation in a porcine coronary model
The mammalian target of Rapamycin controls cell motility through its effectors S6K1 and 4E-BP1
SAFETY AND EFFICACY OF A STEROID-FREE REDUCED-DOSE NEORAL/Rapamycin MAINTENANCE IMMUNOSUPPRESSION IN RENAL TRANSPLANTATION …
inhibition of mTOR signaling with Rapamycin attenuates renal hypertrophy in the early diabetic mice
Combinations of Cytotoxic Drugs, Ionizing Radiation, and Mammalian Target of Rapamycin (mTOR) Inhibitors
Effects of stent-based delivery of Rapamycin and methotrexate on neointimal formation in a porcine coronary model
Rapamycin MANIPULATION OF HOST-DERIVED, ALLOANTIGEN-PULSED DENDRITIC CELLS PLUS POSTOPERATIVE Rapamycin, BUT NOT FK506 …
Ex Vivo Rapamycin Generates Th2 Cells with Enhanced Mitochondrial Function and Reduced Apoptosis Via Intrinsic and Extrinsic Pathways.
combination with the immunosuppressive drug Rapamycin, seems to forestall rejection in mice. Transferring this protocol to the human clinic should be fairly straight …
Rapamycin-generated CD4+, Th2 cells modulate graft-versus-host reaction via an IL-4 dependent mechanism
The assessment of human islets for transplantation and the effect of the immunosuppressant Rapamycin on MIN-6 cells, rat and human islets
549: The Effect of Rapamycin Immunosuppression on Native Polycystic Kidney Volumes in Renal Transplant Patients
Calcineurin inhibitors but not Rapamycin abrogate activation of the immunomodulatory enzyme indoleamine 2, 3-dioxygenase.
Translational control of gene expression in rat liver in relation to mammalian target of Rapamycin signaling
Rapamycin Protects Allografts From Rejection While Simultaneously Attacking Tumors in Immunosuppressed Mice
Rapamycin and IL-10 induce Ag-specific T regulatory type 1 cells (Tr1) and b-islet allograft tolerance in diabetic mice
In Vitro and in Vivo Cyclosporine-Induced Tumor Angiogenesis and Tumor Growth Are Blocked By Simultaneous Application of Rapamycin
Rapamycin INHIBITS EPSTEIN BARR VIRUS+ B CELL LYMPHOMA THROUGH MODULATION OF CELL CYCLE PROTEIN EXPRESSION.
Newly identified kit ITD in childhood AML induces ligand independent growth and is responsive to a synergistic effect of imatinib and Rapamycin
Effects of the immunomodulatory drugs tacrolimus, Rapamycin and cilomilast on dendritic cell function in a model of allergic contact dermatitis
Rapamycin exerts an anti-inflammatory action in vitro and in vivo by inducing monocyte apoptosis and modulating cytokine/chemokines secretion
Site specific systemic delivery of Rapamycin with perfluorobutane gas microbubble carrier reduced neointimal formation in the porcine coronary restenosis model
Rapamycin sensitizes tumor cells to chemotherapy-induced apoptosis and induces cell cycle arrest in ALK+ anaplastic large cell lymphoma.
Sustained Rapamycin Drug Delivery System for Prevention of High Risk Corneal Allograft Rejection and Neovascularization in Rabbits
Everolimus Is Comparably Effective to Rapamycin Acting Synergistically with Imatinib in the Treatment of Constitutively Active Mutations of the Juxtamembrane …
Unrestricted Utilization of Sirolimus-Eluting Stents in the “Real World”: The Rapamycin-Eluting Stent Evaluated At Rotterdam Cardiology Hospital …
Serotonin-mediated activation of Rapamycin-sensitive S6 kinase-S6 ribosomal protein signal transduction pathway in synaptosomes.
Rapamycin INHIBITS EPSTEIN BARR VIRUS+ B CELL LYMPHOMA PROLIFERATION THROUGH MODULATION OF CELL CYCLE PROTEIN EXPRESSION.
Effects of Rapamycin Eluting Stents on Blood Tissue Factor and Tissue Factor Pathway Inhibitor in Patients With Acute Coronary Syndromes
DONOR SPECIFIC TRANSFUSION COMBINED WITH Rapamycin PROLONGED THE CARDIAC GRAFT SURVIVAL IN MICE.
Activity of panitumumab plus Rapamycin against wild type (WT) and mutant epidermal growth factor receptor (EGFr)-expressing NSCLC xenografts
TACROLIMUS DECREASES, CYCLOSPORINE INCREASES, AND Rapamycin HAS NO EFFECT ON PROFIBROTIC GENE MRNA EXPRESSION IN RENAL …
Rapamycin Generated Murine Th2/Tc2 Cells Potently Abrogate Fully MHC-Mismatched Hematopoietic Stem Cell (HSC) Graft Rejection.
548: inhibition of the mTOR Pathway by Rapamycin Reverses Renal Cystogenesis in Polycystic Kidney Disease Models
The mTOR inhibitor Rapamycin inhibits p27 protein degradation by downregulating the expression of its ubiquitin ligase Skp2 in breast cancer
Induction of apoptosis in Ewing’s Sarcoma cells by simultaneous treatment with antisense oligodeoxynucleotides (AS-ODNs) to the EWS/FLI-1 gene and Rapamycin
Construction of eukaryotic expression vector of mammalian target of Rapamycin antisense RNA and its expression in vascular smooth muscle cell
INFLUENCE OF IMMUNOPHILLINS INHIBITORS–CYCLOSPORINE-A, TACROLIMUS AND Rapamycin–ON INSULIN SECRETION IN HEART TRANSPLANT …
Targeting the ICOS-B7h Costimulatory Pathway Synergizes with Rapamycin to Regulate Alloresponses in Islet Transplantation: 0102
Short and long-term therapeutic effects of Rapamycin-eluting stent and paclitaxel-eluting stent in treatment of coronary disease with complicated lesions
The Immunomodulatory Agent Rapamycin Potentiates the Antiviral Activity of the Fusion Inhibitor T20 Against R5 Strains of HIV-1
Binding of mTOR (Mammalian Target of Rapamycin) to the Raptor-eIF4E-4EBP1 complex changes during myogenic differentiation.
COMBINATION OF Rapamycin AND ANTI-LFA-1 PREVENTS REJECTION OF RAT ISLET XENOGRAFTS.: 042
Hypoxia and Rapamycin induced changes to the cell cycle of multicellular spheroids and human tumour xenografts leading to potential therapeutic advantage
1853: A Propsective Study With Thymoglobulin/Daclizumab Induction, Tacrolimus and Steroid Maintenance, Comparing Rapamycin With Mycophenolate Mofetil as …
Anti-angiogenic and immunomodulatory effects of Rapamycin on pancreatic islet endothelial cells: relevance for islets engraftment after transplantation
A comparison study on FTY720, 40-O-(2-hydroxyethyl)-Rapamycin and cyclosporine to prolong the survival of mouse heart allograft
Role of p53 in TRAIL-induced apoptosis in glioblastoma multiforme and modulation by taxol, Rapamycin or temozolomide
DIFFERENTIAL EFFECT OF CALCINEURIN INHIBITORS, ANTI-CD25 ANTIBODIES AND Rapamycin ON THE INDUCTION OF FOXP3 IN HUMAN T-CELLS IN VIVO …
… mechanisms regulating proliferation, antigen responsiveness, and differentiation of CD4⁺ T lymphocytes: a central role for the mammalian target of Rapamycin (mTOR …
Overexpression of a critical target of Rapamycin, translation regulatory protein 4E-BP1, is largely restricted to locally advanced breast and prostate cancers and is lost …
Receptor activator of NF-kB (RANK) and its ligand RANK-L coincide with expression of Rapamycin receptor FKBP12 in neointimal dendritic cells
The PI3K inhibitor LY294002 and the mTOR inhibitor Rapamycin sensitize melanoma cells to cisplatin and temozolomide
Rapamycin and Anti-LFA-1 Monoclonal Antibody Prevent the Rejection of Rat Islet Xenografts and Induce Tolerance in BALB/c Mice
Glucagon Represses Insulin Signaling through Mammalian Target of Rapamycin (mTOR) in Perfused Rat Liver
MYCOPHENOLATE MOFETIL (MMF)/Rapamycin (RAPA) COMPARED TO OTHER COMMON IMMUNOSUPPRESSIVE REGIMENS IN KIDNEY …
Ras Homologue Enrich in Brain (Rheb) Enhances Hypertrophic Response via the Mammalian Target of Rapamycin (mTOR)/p70S6K Pathway
… OF HUMAN BONE MARROW DERIVED MESENCHYMAL PROGENITORS—A SIGNAL TRANSDUCTION BASE FOR PLEIOTROPY OF Rapamycin DERIVATES.
grammed autophagy in the fat body during the final larval stage. TOR (target of Rapamycin) kinases, the central components of a conserved nutri-ent-sensing …
ANTI-CD25 MAB, ANTI-IL2 MAB AND IL2 BLOCK TOLERANCE INDUCTION THROUGH ANTI-CD154 MAB AND Rapamycin IN XENOGENEIC ISLET …
Schedule-dependent activity of combined epidermal growth factor receptor (EGFR) and mammalian target of Rapamycin (mTOR) targeting in PTEN negative breast …
Differential effects of the immunosuppressive agents cyclosporine A, Rapamycin and FK-506 on drug transport by the ATP-binding cassette (ABC) proteins P …
Amino acid transporter ASCT2 expression regulates mammalian Target‐of‐Rapamycin (mTOR) growth and survival signaling in human hepatoma cells
… WITHDRAWAL (PW) TRIAL IN KIDNEY TRANSPLANT PATIENTS TREATED WITH MYCOPHENOLATE SODIUM (MS) COMPARING Rapamycin® VS. C2 DOSED …
Rapamycin AND ANTI-LFA-1 THERAPY MEDIATE ISLET GRAFT SPECIFIC TOLERANCE IN CONCORDANT XENOGENEIC ISLET TRANSPLANTATION.
PHARMACOKINETICS OF ONCE A DAY DOSE OF CYCLOSPORINE IN COMBINATION WITH Rapamycin AND PREDNISONE IN RENAL TRANSPLANTATION IN …
ROLE OF THE MAMMALIAN TARGET OF Rapamycin IN THE REGULATION OF SKELETAL MUSCLE PROTEIN SYNTHESIS AND eIF2B EPSILON mRNA …
IGF-1 rescues Rapamycin-induced cell growth inhibition
CONCOMITANT USE OF CYCLOSPORINE-A (CyA) AND Rapamycin (RAPA) WITH A CONSECUTIVE CONVERSION TO RAPA AND MYCOPHENOLATE MOFETIL …
UP-02.50: A study of the role of insulin like growth factor 1 (IGF1) and Rapamycin sensitive signaling in an androgen independent prostate cancer cell line
… GROWTH FACTOR RECEPTOR (EGFR) INHIBITOR GEFITINIB AND THE MAMMALIAN TARGET OF Rapamycin (mTOR) INHIBITOR EVEROLIMUS
QUADRUPLE IMMUNOSUPPERSSIVE MAINTENANCE THERAPY USING Rapamycin, LOW-DOSE CYCLOSPORINE, MYCOPHENOLATE MOFETIL, AND …
PJ-138 New Sesquiterpene Lactone Compared with Rapamycin Inhibits Migration Rather than Proliferation in Rat Vascular Smooth Muscle Cells
Combination therapy targeting the EWS/FLI-1 oncogene with antisense oligonucleotides and Rapamycin induces apoptosis of Ewing’s sarcoma cells in vitro and …
… 3-kinase; RTK, receptor tyrosine kinase; S6K, ribosomal S6 kinase; TNF-α, tumor necrosis factor α; TOR, target of Rapamycin; TSC, tuberous sclerosis complex …
LONG-TERM LIMB ALLOGRAFT SURVIVAL USING A SHORT COURSE OF ANTI-CD45RB MONOCLONAL ANTIBODY, LF15-0195 AND Rapamycin IN A MOUSE …
A role for HO-1 in the renal function impairment in Rapamycin-treated animals submitted to ischemic and reperfusion injury (IRI).
Bone Morphogenetic Protein 2 (BMP-2) promotes foci formation through the activation of mammalian target of Rapamycin
GSK-3/Rb12 Pathway as a Novel Target of Rapamycin in Prostate Cancer
PII‐9: Improved platelet function in renal transplant patients after conversion from azathioprin to Rapamycin
Drug-eluting stents, 5-sirolimus stents and oral Rapamycin
Autophagic Cell Death in Leukemia Cells Regulated by Ceramide and Sphingosine-1-Phosphate through Mammalian Target of Rapamycin.
4-(N-Methyl-N-nitrosamino)-1 (3-pyridyl)-1-butanone (NNK) Restored the Cap-dependent Protein Translation Blocked by Rapamycin
The Saccharomyces cerevisiae GATA-factor activators’ response to the 14-3-3 proteins, nutrient limitation, Rapamycin and MSX treatment, and cis-acting …
1871: Rapamycin and Ischemia on Experimental Transplant Arteriosclerosis
1158-52 Proteomic profiling of restenotic lesions unveils increased expression of structural proteins that are inhibited by intramural delivery of Rapamycin
… and Activator of Transcription-1 (STAT1)-dependent Gene Transcription by Lipopolysaccharide and InterferonγIs Regulated by Mammalian Target of Rapamycin
P-205 STUDIES ON FUNGAL SECONDARY METABOLISM USING Rapamycin AS A MOLECULAR PROBE
Sphingosine-1-phosphate–induced smooth muscle cell migration involves the mammalian target of Rapamycin
Rapamycin: something old, something new, sometimes borrowed and now renewed
Rapamycin and mTOR kinase inhibitors
Rapamycin is a neuroprotective treatment for traumatic brain injury
Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex
Rapamycin prevents early steps of the development of diabetic nephropathy in rats
Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism
Targeting mammalian target of Rapamycin (mTOR) for health and diseases
A role for mammalian target of Rapamycin in regulating T cell activation versus anergy
A rational mechanism for combination treatment of Huntington’s disease using lithium and Rapamycin
Antitumor activity of Rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
The Rapamycin-binding domain of the protein kinase mammalian target of Rapamycin is a destabilizing domain
The mammalian target of Rapamycin signaling pathway: twists and turns in the road to cancer therapy
The mammalian target of Rapamycin complex 2 controls folding and stability of Akt and protein kinase C
Rapamycin, a specific inhibitor of the mammalian target of Rapamycin, suppresses lymphangiogenesis and lymphatic metastasis
Neuroprotection of Rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement
inhibition of the mammalian target of Rapamycin impedes lymphangiogenesis
Contrasting Effects of Cyclosporine and Rapamycin in De Novo Generation of Alloantigen‐Specific Regulatory T Cells
Metformin inhibits mammalian target of Rapamycin–dependent translation initiation in breast cancer cells
Roles of rapH and rapG in positive regulation of Rapamycin biosynthesis in Streptomyces hygroscopicus
Temsirolimus, an inhibitor of mammalian target of Rapamycin
The Mammalian target of Rapamycin pathway regulates nutrient-sensitive glucose uptake in man
Silencing mammalian target of Rapamycin signaling by small interfering RNA enhances Rapamycin-induced autophagy in malignant glioma cells
Selective survival of naturally occurring human CD4+ CD25+ Foxp3+ regulatory T cells cultured with Rapamycin
Mammalian target of Rapamycin is activated in human gastric cancer and serves as a target for therapy in an experimental model
Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells
mTOR inhibition by Rapamycin prevents β-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes
The mammalian target of Rapamycin-signaling pathway in regulating metabolism and growth,
Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
Hypoxia-inducible factor 1α is regulated by the mammalian target of Rapamycin (mTOR) via an mTOR signaling motif
Rapamycin inhibits the growth and muscle-sparing effects of clenbuterol
Rapamycin treatment for a child with germline PTEN mutation
Effect of Rapamycin alone and in combination with sorafenib in an orthotopic model of human hepatocellular carcinoma
PRAS40 is a target for mammalian target of Rapamycin complex 1 and is required for signaling downstream of this complex
Use of sirolimus (Rapamycin) to treat refractory Crohn’s disease
Rapamycin affects early fracture healing in mice
Mammalian target of Rapamycin inhibition as a therapeutic strategy in the management of urologic malignancies
The role of hypothalamic mammalian target of Rapamycin complex 1 signaling in diet-induced obesity
Re-evaluating the roles of proposed modulators of mammalian target of Rapamycin complex 1 (mTORC1) signaling
Mammalian target of Rapamycin inhibitor dyslipidemia in kidney transplant recipients
Dose-and schedule-dependent inhibition of the mammalian target of Rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with …
Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins
Rapamycin prevents thyroid hormone-induced cardiac hypertrophy
Mammalian target of Rapamycin (mTOR) orchestrates the defense program of innate immune cells
Rapamycin modulates the eNOS vs. shear stress relationship
Rapamycin inhibits trypanosome cell growth by preventing TOR complex 2 formation
The mammalian target of Rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes
Gonadal impact of target of Rapamycin inhibitors (sirolimus and everolimus) in male patients: an overview
Phase I trial of the novel mammalian target of Rapamycin inhibitor deforolimus (AP23573; MK-8669) administered intravenously daily for 5 days every 2 weeks to …
Randomized trial of three Rapamycin-eluting stents with different coating strategies for the reduction of coronary restenosis
Toll-like receptor–mediated induction of type I interferon in plasmacytoid dendritic cells requires the Rapamycin-sensitive PI (3) K-mTOR-p70S6K pathway
The role of mammalian target of Rapamycin inhibitors in the treatment of advanced renal cancer
Effects of immunosuppressive drugs on purified human B cells: evidence supporting the use of MMF and Rapamycin
Mammalian target of Rapamycin as a therapeutic target in oncology
Pilot study of Rapamycin in patients with hormone-refractory prostate cancer
Regulation of androgen receptor transcriptional activity by Rapamycin in prostate cancer cell proliferation and survival
Changes in tumor metabolism as readout for Mammalian target of Rapamycin kinase inhibition by Rapamycin in glioblastoma
Response of a neuronal model of tuberous sclerosis to mammalian target of Rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved …
inhibition of Mammalian target of Rapamycin by Rapamycin causes the regression of carcinogen-induced skin tumor lesions
Chemoprevention and treatment of experimental Cowden’s disease by mTOR inhibition with Rapamycin
Antitumor activity of Rapamycin and octreotide as single agents or in combination in neuroendocrine tumors
In human endothelial cells Rapamycin causes mTORC2 inhibition and impairs cell viability and function
Mammalian target of Rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells
Mammalian target of Rapamycin pathway activity in hepatocellular carcinomas of patients undergoing liver transplantation
Differential impact of mammalian target of Rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells
Rapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signaling
Dissecting the Akt/mammalian target of Rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative
Rapamycin impairs in vivo proliferation of islet beta-cells
Total synthesis of Rapamycin
Regulation of elongation phase of mRNA translation in diabetic nephropathy: amelioration by Rapamycin
Systemic inhibition of mammalian target of Rapamycin inhibits fear memory reconsolidation
The Target of Rapamycin pathway antagonizes pha-4/FoxA to control development and aging
Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+ CD25+ FOXP3+ regulatory T-cells
Mammalian target of Rapamycin in the human placenta regulates leucine transport and is down‐regulated in restricted fetal growth
The mTOR inhibitor Rapamycin significantly improves facial angiofibroma lesions in a patient with tuberous sclerosis
Rapamycin inhibits osteoblast proliferation and differentiation in MC3T3‐E1 cells and primary mouse bone marrow stromal cells
Antidepressive-like effects of Rapamycin in animal models: Implications for mTOR inhibition as a new target for treatment of affective disorders
Alterations in mammalian target of Rapamycin signaling pathways after traumatic brain injury
Regulatory effects of mammalian target of Rapamycin-activated pathways in type I and II interferon signaling
Preparation of Rapamycin-loaded chitosan/PLA nanoparticles for immunosuppression in corneal transplantation
Bnip3 mediates the hypoxia-induced inhibition on mammalian target of Rapamycin by interacting with Rheb
Sirolimus (Rapamycin): from the soil of Easter Island to a bright future
Susceptibility of human mesenchymal stem cells to tacrolimus, mycophenolic acid, and Rapamycin
AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of Rapamycin/p70S6K1 pathway
Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ …
Rapamycin, not cyclosporine, permits thymic generation and peripheral preservation of CD4+ CD25+ FoxP3+ T cells
Dietary energy balance modulates signaling through the Akt/mammalian target of Rapamycin pathways in multiple epithelial tissues
Rapamycin attenuates the severity of established nephritis in lupus-prone NZB/WF1 mice
Isolation of hyperactive mutants of mammalian target of Rapamycin
P-Rex1 links mammalian target of Rapamycin signaling to Rac activation and cell migration
Rapamycin inhibits polyglutamine aggregation independently of autophagy by reducing protein synthesis
Bevacizumab and Rapamycin induce growth suppression in mouse models of hepatocellular carcinoma
Phosphoprotein pathway mapping: Akt/mammalian target of Rapamycin activation is negatively associated with childhood rhabdomyosarcoma survival
Delivery of Rapamycin by PLGA nanoparticles enhances its suppressive activity on dendritic cells
Rapamycin regulates the phosphorylation of rictor
Inhibitors of mammalian target of Rapamycin downregulate MYCN protein expression and inhibit neuroblastoma growth in vitro and in vivo
Distinct signaling mechanisms activate the target of Rapamycin in response to different B‐cell stimuli
Therapeutic effect of Rapamycin on gallbladder cancer in a transgenic mouse model
Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common …
Activated mammalian target of Rapamycin is an adverse prognostic factor in patients with biliary tract adenocarcinoma
Expression of an activated mammalian target of Rapamycin in adenocarcinoma of the cervix: A potential biomarker and molecular target therapy
The effect of immunosuppressive drug Rapamycin on regulatory CD4+ CD25+ Foxp3+ T cells in mice
Impact of Rapamycin on liver regeneration
Curcumin inhibits Akt/mammalian target of Rapamycin signaling through protein phosphatase-dependent mechanism
Combination of Rapamycin and IL-2 increases de novo induction of human CD4+ CD25+ FOXP3+ T cells
Translational control of c-MYC by Rapamycin promotes terminal myeloid differentiation
Rapamycin inhibits proliferation of estrogen-receptor-positive breast cancer cells
An activated mTOR/p70S6K signaling pathway in esophageal squamous cell carcinoma cell lines and inhibition of the pathway by Rapamycin and siRNA against …
Mammalian target of Rapamycin contributes to the acquired apoptotic resistance of human mesothelioma multicellular spheroids
Evaluation of antileukaemic effects of Rapamycin in patients with imatinib‐resistant chronic myeloid leukaemia
Antiproliferative effects of Rapamycin as a single agent and in combination with carboplatin and paclitaxel in head and neck cancer cell lines
Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt2 feedback signaling
Mammalian target of Rapamycin: master regulator of cell growth in the nervous system
Binding of Rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities
Epstein Barr virus, Rapamycin, and host immune responses
Regression of subependymal giant cell astrocytoma with Rapamycin in tuberous sclerosis complex
Effect of Rapamycin on wound healing: an experimental study
Saccharomyces cerevisiae FKBP12 binds Arabidopsis thaliana TOR and its expression in plants leads to Rapamycin susceptibility
ASCT2 silencing regulates mammalian target-of-Rapamycin growth and survival signaling in human hepatoma cells
Small molecule enhancers of Rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington’s disease models and enhance killing of …
Mammalian target of Rapamycin (mTOR) is involved in the neuronal differentiation of neural progenitors induced by insulin
Defects in skin γδ T cell function contribute to delayed wound repair in Rapamycin-treated mice
Effective in vivo targeting of the mammalian target of Rapamycin pathway in malignant peripheral nerve sheath tumors
Rapamycin, but not cyclosporine or FK506, alters natural killer cell function
IL-1β-driven ST2L expression promotes maturation resistance in Rapamycin-conditioned dendritic cells
Mitogen-activated protein kinase upregulates the dendritic translation machinery in long-term potentiation by controlling the mammalian target of Rapamycin pathway
CXCR6 induces prostate cancer progression by the AKT/mammalian target of Rapamycin signaling pathway
Combination strategy targeting the hypoxia inducible factor-1α with mammalian target of Rapamycin and histone deacetylase inhibitors
Pharmacometrics and delivery of novel nanoformulated PEG-b-poly (ε-caprolactone) micelles of Rapamycin
Calcineurin inhibitors and Rapamycin: cancer protection or promotion?
A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of Rapamycin (mTOR) in high-protein diet–induced weight loss
… exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt/mammalian target of Rapamycin …
Endoplasmic reticulum and Golgi localization sequences for mammalian target of Rapamycin
Mammalian target of Rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute …
Rapamycin inhibits cell growth by induction of apoptosis on hepatocellular carcinoma cells in vitro
Identification of a Highly Effective Rapamycin Schedule that Markedly Reduces the Size, Multiplicity, and Phenotypic Progression of Tobacco Carcinogen–Induced …
Rapamycin prevents the development of nephritis in lupus-prone NZB/WF1 mice
Targeting human medulloblastoma: oncolytic virotherapy with myxoma virus is enhanced by Rapamycin
Rapamycin as an inhibitor of osteogenic differentiation in bone marrow-derived mesenchymal stem cells
Rapamycin attenuates hypoxia-induced pulmonary vascular remodeling and right ventricular hypertrophy in mice
Intramural Delivery of Rapamycin With αvβ3-Targeted Paramagnetic Nanoparticles Inhibits Stenosis After Balloon Injury
FK506 binding protein mediates glioma cell growth and sensitivity to Rapamycin treatment by regulating NF-κB signaling pathway
Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: Rapamycin triggers dephosphorylation and delocalization of the mTORC2 …
Oncogenic tyrosine kinase NPM/ALK induces activation of the Rapamycin-sensitive mTOR signaling pathway
Target of Rapamycin (TOR) signaling controls epithelial morphogenesis in the vertebrate intestine
Antiangiogenic therapy with mammalian target of Rapamycin inhibitor RAD001 (Everolimus) increases radiosensitivity in solid cancer
Mammalian target of Rapamycin and S6 kinase 1 positively regulate 6-thioguanine-induced autophagy
Preparation and characterization of Rapamycin-loaded PLGA coating stent
Longitudinal inhibition of PI3K/Akt/mTOR signaling by LY294002 and Rapamycin induces growth arrest of adult T-cell leukemia cells
Suppression of Peutz-Jeghers polyposis by targeting mammalian target of Rapamycin signaling
Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor with potent in …
Rapamycin retards growth and causes marked alterations in the growth plate of young rats
… fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of Rapamycin (mTOR) signaling cascade
Autophagy activation by Rapamycin eliminates mouse Mallory‐Denk bodies and blocks their proteasome inhibitor‐mediated formation
Mammalian target of Rapamycin inhibitors as possible adjuvant therapy for microscopic residual disease in head and neck squamous cell cancer
Defective TGF-β signaling sensitizes human cancer cells to Rapamycin
A retroinhibition approach reveals a tumor cell–autonomous response to Rapamycin in head and neck cancer
Effects of Rapamycin on gene expression, morphology, and electrophysiological properties of rat hippocampal neurons
inhibition of mammalian target of Rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E …
Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of Rapamycin in mammary carcinomas, mammary gland …
Targeting Protein Translation in Human Non–Small Cell Lung Cancer via Combined MEK and Mammalian Target of Rapamycin Suppression
Activation of mammalian target of Rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes
… concentrations targets the translational machinery to increase the proliferation of human breast cancer cells: involvement of mammalian target of Rapamycin/eIF4E …
Enhancing mammalian target of Rapamycin (mTOR)–targeted cancer therapy by preventing mTOR/Raptor inhibition-initiated, mTOR/Rictor-independent Akt activation
Leucine stimulates mammalian target of Rapamycin signaling in C2C12 myoblasts in part through inhibition of adenosine monophosphate-activated protein kinase
Rapamycin Inhibits Proliferation of Epstein-Barr Virus–Positive B-cell Lymphomas Through Modulation of Cell-Cycle Protein Expression
Solution structure of the Legionella pneumophila Mip-Rapamycin complex
Combined therapeutic effects of vinblastine and Rapamycin on human neuroblastoma growth, apoptosis, and angiogenesis
Azoospermia in a renal transplant recipient during sirolimus (Rapamycin) treatment
Differential involvement of IκB kinases α and β in cytokine-and insulin-induced mammalian target of Rapamycin activation determined by Akt
The role of targeting mammalian target of Rapamycin in lung cancer
Amelioration of protein misfolding disease by Rapamycin: translation or autophagy?
Monitoring biological action of Rapamycin in renal transplantation
Efficacy of Rapamycin in scleroderma: a case study
Statin therapy, alone or with Rapamycin, does not reverse monocrotaline pulmonary arterial hypertension: the rapamcyin-atorvastatin-simvastatin study
Target of Rapamycin and LST8 proteins associate with membranes from the endoplasmic reticulum in the unicellular green alga Chlamydomonas reinhardtii
Regulation of mammalian target of Rapamycin activity in PTEN-inactive prostate cancer cells by IκB kinase α
… regulates hippocampal neurons by elevation of intracellular calcium and activation of calcium/calmodulin protein kinase II and mammalian target of Rapamycin
The Akt/mammalian target of Rapamycin signal transduction pathway is activated in high-risk myelodysplastic syndromes and influences cell survival and proliferation
The mammalian target of Rapamycin pathway as a potential target for cancer chemoprevention
Rapamycin: brain excitability studied in vitro
Rapamycin‐mediated G1 arrest involves regulation of the Cdk inhibitor Sic1 in Saccharomyces cerevisiae
Rapamycin-conditioned, alloantigen-pulsed dendritic cells promote indefinite survival of vascularized skin allografts in association with T regulatory cell expansion
Adiponectin signals in prostate cancer cells through Akt to activate the mammalian target of Rapamycin pathway
Acidosis-sensing glutamine pump SNAT2 determines amino acid levels and mammalian target of Rapamycin signalling to protein synthesis in L6 muscle cells
Phosphorylation of ribosomal p70 S6 kinase and Rapamycin sensitivity in human colorectal cancer
Mammalian Target of Rapamycin Repression by 3, 3′-Diindolylmethane Inhibits Invasion and Angiogenesis in Platelet-Derived Growth Factor-D–Overexpressing …
Endothelial Akt signaling is rate-limiting for Rapamycin inhibition of mouse mammary tumor progression
Aging, stem cells, and mammalian target of Rapamycin: a prospect of pharmacologic rejuvenation of aging stem cells
The mammalian target of Rapamycin kinase and tumor growth inhibition
Nonimmunosuppressive effects of mammalian target of Rapamycin inhibitors
Rapamycin reduces VEGF expression in retinal pigment epithelium (RPE) and inhibits RPE-induced sprouting angiogenesis in vitro
Interplay of PI3K and cAMP/PKA signaling, and Rapamycin-hypersensitivity in TGFβ1 enhancement of FSH-stimulated steroidogenesis in rat ovarian …
… human vascular smooth muscle cell proliferation and intimal expansion by phosphatidylinositol 3-kinase–dependent mammalian target of Rapamycin raptor complex 1 …
mTOR is the Rapamycin-sensitive kinase that confers mechanically-induced phosphorylation of the hydrophobic motif site Thr (389) in p70S6k
Oncolytic virotherapy synergism with signaling inhibitors: Rapamycin increases myxoma virus tropism for human tumor cells
Juvenile hormone connects larval nutrition with target of Rapamycin signaling in the mosquito Aedes aegypti
Rapamycin suppresses TLR4-triggered IL-6 and PGE2 production of colon cancer cells by inhibiting TLR4 expression and NF-κB activation
Protein phosphatase 2A and Rapamycin regulate the nuclear localization and activity of the transcription factor GLI3
Effect of Rapamycin therapy on coronary artery physiology early after cardiac transplantation
Low-dose mTOR inhibition by Rapamycin attenuates progression in anti-thy1-induced chronic glomerulosclerosis of the rat
Immunosuppression and tumor development in organ transplant recipients: the emerging dualistic role of Rapamycin
Bevacizumab and Rapamycin inhibit tumor growth in peritoneal model of human ovarian cancer
Effects of the dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging
IL-2– and IL-15–induced activation of the Rapamycin-sensitive mTORC1 pathway in malignant CD4+ T lymphocytes
Mammalian Target of Rapamycin (mTOR) is Activated in Cutaneous Vascular Malformations in Vivo
Reduction of CCR5 with low-dose Rapamycin enhances the antiviral activity of vicriviroc against both sensitive and drug-resistant HIV-1
Evaluation of the mammalian target of Rapamycin pathway and the effect of Rapamycin on target expression and cellular proliferation in osteosarcoma cells from dogs
Differential effects of Rapamycin in anti-GBM glomerulonephritis
Rapamycin inhibits PAI-1 expression and reduces interstitial fibrosis and glomerulosclerosis in chronic allograft nephropathy
Coupling of mammalian target of Rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2a-and glycogen synthase …
Mammalian target of Rapamycin and caspase inhibitors in polycystic kidney disease
Pharmacodynamic-guided modified continuous reassessment method–based, dose-finding study of Rapamycin in adult patients with solid tumors
Statin-dependent suppression of the Akt/mammalian target of Rapamycin signaling cascade and programmed cell death 4 up-regulation in renal cell carcinoma
Impact of mammalian target of Rapamycin inhibition on lymphoid homing and tolerogenic function of nanoparticle-labeled dendritic cells following allogeneic …
Antiproliferative and proapoptotic effects of Rapamycin and celecoxib in malignant melanoma cell lines
Role of the phosphoinositide 3-kinase-Akt-mammalian target of the Rapamycin signaling pathway in long-term potentiation and trace fear conditioning memory in rat …
Exploiting the mammalian target of Rapamycin pathway in hematologic malignancies
Simultaneous hybrid coronary revascularization using totally endoscopic left internal mammary artery bypass grafting and placement of Rapamycin eluting stents in the …
Degradation of Rapamycin and its ring-opened isomer: role of base catalysis
Sensitizing HER2-overexpressing cancer cells to luteolin-induced apoptosis through suppressing p21WAF1/CIP1 expression with Rapamycin
Superoxide anions regulate TORC1 and its ability to bind Fpr1: Rapamycin complex
The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of Rapamycin complex 1
Topical Rapamycin inhibits tuberous sclerosis tumor growth in a nude mouse model
Cardiac restricted overexpression of kinase-dead mammalian target of Rapamycin (mTOR) mutant impairs the mTOR-mediated signaling and cardiac function
Rapamycin at subimmunosuppressive levels inhibits mesangial cell proliferation and extracellular matrix production
Mammalian target of Rapamycin (mTOR) pathway signalling in lymphomas
Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and Rapamycin combination therapy
Nucleophosmin mediates mammalian target of Rapamycin–Dependent actin cytoskeleton dynamics and proliferation in neurofibromin-deficient astrocytes
Effects of Rapamycin on cell proliferation and phosphorylation of mTOR and p70S6K in HepG2 and HepG2 cells overexpressing constitutively active Akt/PKB
Mammalian target of Rapamycin inhibition halts the progression of proteinuria in a rat model of reduced renal mass
Fatty acid synthase inhibitors modulate energy balance via mammalian target of Rapamycin complex 1 signaling in the central nervous system
Rapamycin does not improve insulin sensitivity despite elevated mammalian target of Rapamycin complex 1 activity in muscles of ob/ob mice
inhibition of apoptosis through localized delivery of Rapamycin-loaded nanoparticles prevented neointimal hyperplasia and reendothelialized injured artery
Epithelial-to-mesenchymal transition of human proximal tubular epithelial cells: effects of Rapamycin, mycophenolate, cyclosporin, azathioprine, and …
Regulatory effects of mammalian target of Rapamycin-mediated signals in the generation of arsenic trioxide responses
Leptin induces macrophage lipid body formation by a phosphatidylinositol 3-kinase-and mammalian target of Rapamycin-dependent mechanism
Non‐human primate fetal kidney transcriptome analysis indicates mammalian target of Rapamycin (mTOR) is a central nutrient‐responsive pathway
Compared effect of immunosuppressive drugs cyclosporine A and Rapamycin on cholesterol homeostasis key enzymes CYP27A1 and HMG‐CoA reductase
On the action of cyclosporine A, Rapamycin and tacrolimus on M. avium including subspecies paratuberculosis
Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of Rapamycin complex 1 (mTORC1)-mediated phosphorylation
Improved blood compatibility of Rapamycin-eluting stent by incorporating curcumin
Follicle-stimulating hormone increases tuberin phosphorylation and mammalian target of Rapamycin signaling through an extracellular signal-regulated kinase …
Monitoring antitumor efficacy of Rapamycin in Kaposi sarcoma
Phosphatidylinositol 3-kinase-AKT-mammalian target of Rapamycin pathway is essential for neuroendocrine differentiation of prostate cancer
Rapamycin downregulates the inhibitory receptors ILT2, ILT3, ILT4 on human dendritic cells and yet induces T cell hyporesponsiveness independent of FoxP3 …
Initial testing (stage 1) of the mTOR inhibitor Rapamycin by the pediatric preclinical testing program
Insulin‐like growth factor‐1 (IGF‐1) and leucine activate pig myogenic satellite cells through mammalian target of Rapamycin (mTOR) pathway
Rapamycin impairs β-cell proliferation in vivo
… acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of Rapamycin …
Upstream signaling inhibition enhances Rapamycin effect on growth of kidney cancer cells
Hsf1 activation inhibits Rapamycin resistance and TOR signaling in yeast revealed by combined proteomic and genetic analysis
Cutting edge: Foxp3-mediated induction of pim 2 allows human T regulatory cells to preferentially expand in Rapamycin
The YCR079w gene confers a Rapamycin-resistant function and encodes the sixth type 2C protein phosphatase in Saccharomyces cerevisiae
Combination of Rapamycin and 17-allylamino-17-demethoxygeldanamycin abrogates Akt activation and potentiates mTOR blockade in breast cancer cells
… Signaling Pathway Induces Resistance to the Apoptotic Activities of SCH66336 (Lonafarnib) through Akt/Mammalian Target of Rapamycin–Mediated Increases in …
Antiproliferative effect of Rapamycin on human T-cell leukemia cell line Jurkat by cell cycle arrest and telomerase inhibition
A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of Rapamycin inhibitor, in patients with relapsed or refractory hematologic …
Ocular toxicity and distribution of subconjunctival and intravitreal Rapamycin in horses
Response of U87 glioma xenografts treated with concurrent Rapamycin and fractionated radiotherapy: possible role for thrombosis
Mammalian target of Rapamycin activation impairs hepatocytic differentiation and targets genes moderating lipid homeostasis and hepatocellular growth
Regression of pulmonary lymphangioleiomyomatosis (PLAM)-associated retroperitoneal angiomyolipoma post–lung transplantation with Rapamycin treatment
Regulation of neurogenesis and epidermal growth factor receptor signaling by the insulin receptor/target of Rapamycin pathway in Drosophila
inhibition of mammalian target of Rapamycin signaling by 2-(morpholin-1-yl) pyrimido [2, 1-α] isoquinolin-4-one
Further delineation of the continuous human neoplastic enterochromaffin cell line, KRJ-I, and the inhibitory effects of lanreotide and Rapamycin
Intracellular mechanisms of metabolism regulation: the role of signaling via the mammalian target of Rapamycin pathway and other routes
Loss of tuberous sclerosis complex-2 function and activation of mammalian target of Rapamycin signaling in endometrial carcinoma
The mammalian target of Rapamycin pathway and its role in molecular nutrition regulation
Cotylenin A, a new differentiation inducer, and Rapamycin cooperatively inhibit growth of cancer cells through induction of cyclin G2
Effects of Rapamycin in liver transplantation.
Rapamycin inhibits multiple stages of c-Neu/ErbB2–induced tumor progression in a transgenic mouse model of HER2-positive breast cancer
Rapamycin enriches for CD4+ CD25+ CD27+ Foxp3+ regulatory T cells in ex vivo-expanded CD25-enriched products from healthy donors and patients with …
Rapamycin down-regulates LDL-receptor expression independently of SREBP-2
Differential regulation of vascular endothelial growth factor by Akt and mammalian target of Rapamycin inhibitors in cell lines derived from childhood solid tumors
Forkhead box protein O1 negatively regulates skeletal myocyte differentiation through degradation of mammalian target of Rapamycin pathway components
Effects of Rapamycin on active Heymann nephritis
Rationale for a phase I trial of erlotinib and the mammalian target of Rapamycin inhibitor everolimus (RAD001) for patients with relapsed non–small cell lung cancer
Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of Rapamycin through the STAT3-SOCS3 pathway
Targeting the phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin module for acute myelogenous leukemia therapy: from bench to bedside
Rapamycin reduces CCR5 mRNA levels in macaques: potential applications in HIV-1 prevention and treatment
… and inducible nitric-oxide synthase expression through the integrin/integrin-linked kinase/Akt/mammalian target of Rapamycin pathway in osteoblasts
Rapamycin reverses NPM-ALK-induced glucocorticoid resistance in lymphoid tumor cells by inhibiting mTOR signaling pathway, enhancing G 1 cell cycle …
Rapamycin enhances the number of alloantigen-induced human CD103+ CD8+ regulatory T cells in vitro
GADD34 inhibits mammalian target of Rapamycin signaling via tuberous sclerosis complex and controls cell survival under bioenergetic stress
Delivery of Rapamycin‐loaded nanoparticle down regulates ICAM‐1 expression and maintains an immunosuppressive profile in human CD34+ progenitor‐derived …
Four-year clinical follow-up of the Rapamycin-eluting stent evaluated at Rotterdam Cardiology Hospital registry
Human melanoma cytolysis by combined inhibition of mammalian target of Rapamycin and vascular endothelial growth factor/vascular endothelial growth factor …
Surgical wound‐healing complications in heart transplant recipients treated with Rapamycin
Mammalian target of Rapamycin as a target in hematological malignancies
Does addition of estradiol improve the efficacy of a Rapamycin-eluting stent? Results of the ISAR-PEACE randomized trial
The effects of Rapamycin in the progression of renal fibrosis
Mechanism of apoptosis induced by IFN-α in human myeloma cells: role of Jak1 and Bim and potentiation by Rapamycin
p21-activated kinase 1 is activated through the mammalian target of Rapamycin/p70 S6 kinase pathway and regulates the replication of hepatitis C virus in …
Effect of supplemental dietary zinc on the mammalian target of Rapamycin (mTOR) signaling pathway in skeletal muscle and liver from post-absorptive mice
Combined treatment with triptolide and Rapamycin prolongs graft survival in a mouse model of cardiac transplantation
Synergistic effect of mTOR inhibitor Rapamycin and fluorouracil in inducing apoptosis and cell senescence in hepatocarcinoma cells
Rapamycin stimulates arginine influx through CAT2 transporters in human endothelial cells
Mammalian target of Rapamycin is the key effector of phosphatidylinositol-3-OH–initiated proliferative signals in the thyroid follicular epithelium
Down-regulation of phosphatidylinositol 3′-kinase/AKT/molecular target of Rapamycin metabolic pathway by primary letrozole-based therapy in human breast cancer
The combination of novel low molecular weight inhibitors of RAF (LBT613) and target of Rapamycin (RAD001) decreases glioma proliferation and invasion
EMAP-II downregulation contributes to the beneficial effects of Rapamycin after vascular injury
Rescue of Degradation‐Prone Mutants of the FK506‐Rapamycin Binding (FRB) Protein with Chemical Ligands
Antiproliferative and overadditive effects of Rapamycin and FTY720 in pancreatic cancer cells in vitro
Rapamycin for treatment of refractory dysthyroid compressive optic neuropathy
Randomized trial of Rapamycin-and paclitaxel-eluting stents with identical biodegradable polymeric coating and design
Nutrient content of diet affects the signaling activity of the insulin/target of Rapamycin/p70 S6 kinase pathway in the African malaria mosquito Anopheles gambiae
Rapamycin delays growth of Wnt-1 tumors in spite of suppression of host immunity
Rapamycin together with herceptin significantly increased anti‐tumor efficacy compared to either alone in ErbB2 over expressing breast cancer cells
Short-and long-term effects of cytochalasin D, paclitaxel and Rapamycin on wall thickening in experimental porcine vein grafts
Bile acid exposure up-regulates tuberous sclerosis complex 1/mammalian target of Rapamycin pathway in Barrett’s-associated esophageal adenocarcinoma
A phase II study of oral mammalian target of Rapamycin (mTOR) inhibitor, RAD001 (everolimus), in patients with recurrent endometrial carcinoma (EC)
Rapamycin shows anticancer activity in primary chronic lymphocytic leukemia cells in vitro, as single agent and in drug combination
External application of Rapamycin-eluting film at anastomotic sites inhibits neointimal hyperplasia in a canine model
Rapamycin blunts nutrient stimulation of eIF4G, but not PKCε phosphorylation, in skeletal muscle
ABT-263 and Rapamycin act cooperatively to kill lymphoma cells in vitro and in vivo
mTOR inhibitors (Rapamycin and its derivatives) and nitrogen containing bisphosphonates: bi-functional compounds for the treatment of bone tumours
DCO2 on-line measurement used in Rapamycin fed-batch fermentation process
Identification of the Rapamycin‐sensitive phosphorylation sites within the Ser/Thr‐rich domain of the yeast Npr1 protein kinase
Golgi Manganese Transport Is Required for Rapamycin Signaling in Saccharomyces cerevisiae
How to control lymphangiogenesis: A novel role for Rapamycin
Decorin-mediated regulation of fibrillin-1 in the kidney involves the insulin-like growth factor-I receptor and Mammalian target of Rapamycin
Components of the Vid30c are needed for the Rapamycin-induced degradation of the high-affinity hexose transporter Hxt7p in Saccharomyces cerevisiae
An approach to analyse the specific impact of Rapamycin on mRNA-ribosome association
Ex vivo Rapamycin generates apoptosis-resistant donor Th2 cells that persist in vivo and prevent hemopoietic stem cell graft rejection
Rapamycin-regulated control of antiangiogenic tumor therapy following rAAV-mediated gene transfer
Rapamycin prevents mesenteric neo‐angiogenesis and reduces splanchnic blood flow in portal hypertensive mice
Upregulation of tissue factor expression and thrombogenic activity in human aortic smooth muscle cells by irradiation, Rapamycin and paclitaxel
Chylous ascites in a renal transplant recipient under sirolimus (Rapamycin) treatment
Combination antifungal therapy involving amphotericin B, Rapamycin and 5-fluorocytosine using PEG-phospholipid micelles
Serotonin Induces Memory-Like, Rapamycin-Sensitive Hyperexcitability in Sensory Axons of Aplysia That Contributes to Injury Responses
Activation of the mammalian target of Rapamycin complex 1 is both necessary and sufficient to stimulate eukaryotic initiation factor 2Bɛ mRNA translation and protein …
Human herpesvirus‐8 (HHV‐8)‐associated primary effusion lymphoma in two renal transplant recipients receiving Rapamycin
An RNA Interference Screen Identifies a Novel Regulator of Target of Rapamycin That Mediates Hypoxia Suppression of Translation in Drosophila S2 Cells
Identification of AUF1 as a Rapamycin-responsive binding protein to the 5′-terminal oligopyrimidine element of mRNAs
Mitogen-stimulated and Rapamycin-sensitive glucose transporter 12 targeting and functional glucose transport in renal epithelial cells
Targeting 14-3-3 sensitizes native and mutant BCR-ABL to inhibition with U0126, Rapamycin and Bcl-2 inhibitor GX15-070
Modulation of the activities of AMP‐activated protein kinase, protein kinase B, and mammalian target of Rapamycin by limiting energy availability with 2‐deoxyglucose
PTEN and Rapamycin inhibiting the growth of K562 cells through regulating mTOR signaling pathway
Role of adenosine 5′-monophosphate-activated protein kinase subunits in skeletal muscle mammalian target of Rapamycin signaling
Pharmacokinetics of sirolimus (Rapamycin) in subjects with severe hepatic impairment
… Preconditioning Decreases Myocardial Infarction in Rabbits via Up-regulation of Hypoxia Inducible Factor 1 That Is Mediated by Mammalian Target of Rapamycin
Stress and IGF-I differentially control cell fate through mammalian target of Rapamycin (mTOR) and retinoblastoma protein (pRB)
… of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of the phosphoinositide 3‐kinase–Akt–mammalian target of Rapamycin …
Possible involvement of persistent activity of the mammalian target of Rapamycin pathway in the cisplatin resistance of AFP-producing gastric cancer cells
Cyclin B synthesis and Rapamycin‐sensitive regulation of protein synthesis during starfish oocyte meiotic divisions
Comparison of a polymer‐free Rapamycin‐eluting stent (YUKON) with a polymer‐based paclitaxel‐eluting stent (TAXUS) in real‐world coronary artery lesions
The Rheb switch 2 segment is critical for signaling to target of Rapamycin complex 1
Cyclosporine A and Rapamycin induce in vitro cholesteryl ester transfer protein activity, and suppress lipoprotein lipase activity in human plasma
Rapamycin reduces CCR5 density levels on CD4 T cells, and this effect results in potentiation of enfuvirtide (T-20) against R5 strains of human immunodeficiency …
Three‐year clinical outcomes after coronary stenting of chronic total occlusion using sirolimus‐eluting stents: Insights from the Rapamycin‐eluting stent evaluated at …
Chronic alcohol consumption alters mammalian target of Rapamycin (mTOR), reduces ribosomal p70s6 kinase and p4E-BP1 levels in mouse cerebral cortex
Intrinsically lower AKT, mammalian target of Rapamycin, and hypoxia-inducible factor activity correlates with increased sensitivity to 2-deoxy-D-glucose under hypoxia …
… preclinical studies: timing of treatment, combination of a Rapamycin analog (CCI-779) and interferon-gamma, and comparison of Rapamycin to CCI-779
Rapamycin limits formation of active eukaryotic initiation factor 4F complex following meal feeding in rat hearts
CD8+ T‐Cell Depletion and Rapamycin Synergize with Combined Coreceptor/Stimulation Blockade to Induce Robust Limb Allograft Tolerance in Mice
Antineoplastic effect of Rapamycin is potentiated by inhibition of IRS-1 signaling in prostate cancer cells xenografts
Mammalian target of Rapamycin pathway inhibition enhances the effects of 5-aza-dC on suppressing cell proliferation in human gastric cancer cell lines
The Cairo kidney center protocol for Rapamycin-based sequential immunosuppression in kidney transplant recipients: 2-year outcomes
… of insulin-like growth factor binding protein-2 by MCF-7 breast cancer cells is regulated through the phosphatidylinositol 3-kinase/AKT/mammalian target of Rapamycin …
Total synthesis studies on macrocyclic pipecolic acid natural products: FK506, the antascomicins and Rapamycin
IGF-I receptor inhibition combined with Rapamycin or temsirolimus inhibits neuroblastoma cell growth
Chronic allograft dysfunction: can we use mammalian target of Rapamycin inhibitors to replace calcineurin inhibitors to preserve graft function?
The mammalian target of Rapamycin complex 1 regulates leptin biosynthesis in adipocytes at the level of translation: the role of the 5′-untranslated region in the …
Rapamycin enhances the anti-tumor effect of gemcitabine in pancreatic cancer cells.
Renal cortex neuronal nitric oxide synthase in response to Rapamycin in kidney transplantation
The MAP kinase-activated protein kinase Rck2p plays a role in Rapamycin sensitivity in Saccharomyces cerevisiae and Candida albicans
… Factor‐1 and Transforming Growth Factor‐β Controls the Quiescence/Cycling Switch of CD34+ Progenitors Through FoxO3 and Mammalian Target of Rapamycin
The effect of Rapamycin on DNA synthesis in multiple tissues from late gestation fetal and postnatal rats
Rapamycin reverses TLR4 signaling-triggered tumor apoptosis resistance by disrupting Akt-mediated Bcl-xL upregulation
Reversal of tacrolimus‐related hypertrophic cardiomyopathy after conversion to Rapamycin in a pediatric liver transplant recipient
Mechanisms of mammalian target of Rapamycin inhibition in sarcoma: present and future
siRNA targeting mammalian target of Rapamycin (mTOR) attenuates experimental proliferative vitreoretinopathy
Synthesis, characterization and antiproliferative activity of Rapamycin-loaded poly (N-isopropylacrylamide)-based nanogels in vascular smooth muscle cells
Prolongation of cardiac allograft survival by Rapamycin and the invariant natural killer T cell glycolipid agonist OCH
Rapamycin Inhibits Growth Factor-Induced Cell Cycle Regulation in Pancreatic β Cells
Molecular impacts of Rapamycin-based drug combinations: combining Rapamycin with gemcitabine or imatinib mesylate (Gleevec) in a human leiomyosarcoma model
Rapamycin-induced cytotoxic signal transduction pathway
Effect of rifampicin to inhibit Rapamycin-induced autophagy via the suppression of protein phosphatase 2A activity
Specific mTOR inhibitor Rapamycin enhances cytotoxicity induced by alkylating agent 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea …
Requirements of phosphatidylinositol-3 kinase and mammalian target of Rapamycin for estrogen-induced proliferation in uterine leiomyoma-and myometrium-derived …
Mass balance in Rapamycin autoxidation
Targeting the mammalian target of Rapamycin in myxoid chondrosarcoma
Acetaldehyde promotes Rapamycin-dependent activation of p70S6K and glucose uptake despite inhibition of Akt and mTOR in dopaminergic SH-SY5Y human …
Conversion to Rapamycin immunosuppression for malignancy after kidney transplantation
Normal phase and reverse phase HPLC-UV-MS analysis of process impurities for Rapamycin analog ABT-578: Application to active pharmaceutical ingredient process …
Non-Conventional method for evaluation and optimization of medium components for Rapamycin production by Streptomyces hygroscopicus
Administration of triiodo-L-thyronine into dorsal hippocampus alters phosphorylation of Akt, mammalian target of Rapamycin, p70S6 kinase and 4E-BP1 in rats
Possible mechanism by which Rapamycin increases cyclosporine nephrotoxicity
… Extracellular Signal-regulated Kinase 1/2 and c-Jun NH2-Terminal Kinase Downstream of Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin
Adverse effects of mammalian target of Rapamycin inhibitors during the postoperative period after cardiac transplantation
ABT-869, a multi-targeted tyrosine kinase inhibitor, in combination with Rapamycin is effective for subcutaneous hepatocellular carcinoma xenograft
Neointimal expression of Rapamycin receptor FK506-binding protein FKBP12: postinjury animal and human in-stent restenosis tissue characteristics
Successful treatment of post-renal transplant gastric and pulmonary Kaposi’s sarcoma with conversion to Rapamycin treatment
A comparison of clinical and angiographic outcomes after Excel bioabsorbable polymer versus Firebird durable polymer Rapamycin-eluting stent for the treatment of …
Effect of Rapamycin on hepatocyte function and proliferation induced by growth factors
Lentiviral vectors mediate nonimmunosuppressive Rapamycin analog-induced production of secreted therapeutic factors in the brain: regulation at the level of …
Rapamycin bypasses vesicle-mediated signaling events to activate Gln3 in Saccharomyces cerevisiae
Nanoparticle albumin-bound (nab) Rapamycin as an anticancer agent
Rapamycin conditionally inhibits Hsp90 but not Hsp70 mRNA translation in Drosophila: implications for the mechanisms of Hsp mRNA translation
Differential modulation of mitogen driven proliferation and homeostasis driven proliferation of T cells by Rapamycin, Ly294002 and chlorophyllin
A phase 1b study of oral Rapamycin (sirolimus) in patients with advanced malignancies
Rapamycin-loaded poly (lactic-co-glycolic) acid nanoparticles for intraarterial local drug delivery: preparation, characterization, and in vitro/in vivo release
A Combination of Donor Specific Transfusion and Rapamycin Prolonges Cardiac Allograft Survival in Mice
Immunoassay determination of Rapamycin: reliability of the method with respect to liquid chromatography mass spectrometric quantification
Thrombin induces osteoprotegerin synthesis via phosphatidylinositol 3′‐kinase/mammalian target of Rapamycin pathway in human periodontal ligament cells
Galectin-1 upregulates glucose transporter-1 expression level via protein kinase C, phosphoinositol-3 kinase, and mammalian target of Rapamycin pathways in mouse …
inhibition of the mammalian target of Rapamycin (mTOR) in a case of refractory primary cutaneous anaplastic large cell lymphoma
Magic with Rapamycin
Rapamycin promotes emergence of IL-10-secreting donor lymphocyte infusion-derived T cells without compromising their graft-versus-leukemia reactivity
Rapamycin and cyclosporine have different effects on expression of Ang-1 and Ang-2 and Tie2 in rat renal allograft with chronic allograft nephropathy
Phorbol 12-myristate 13-acetate and serum synergize to promote Rapamycin-insensitive cell proliferation via protein kinase C-eta
A recent application of fluoro-18-deoxyglucose positron emission tomography, treatment monitoring with a mammalian target of Rapamycin inhibitor: an example …
Orally administered Rapamycin, dacarbazine or both for treatment of human melanoma evaluated in severe combined immunodeficiency mice
… /p70S6K signaling pathway constitutively activated in esophageal squamous cell carcinona cell lines and inhibition of the pathway by Rapamycin and siRNA against …
Anti-CD25 mAb, anti-IL2 mAb, and IL2 block tolerance induction through anti-CD154 mAb and Rapamycin in xenogeneic islet transplantation
Effect of chemotherapy with cisplatin and Rapamycin against Hep-2 cells in vitro
A new trick for an old drug: mTOR inhibitor Rapamycin augments the effect of fluorouracil on hepatocellular carcinoma by inducing cell senescence
Loss of phosphatase and tensin homologue deleted on chromosome 10 and phosphorylation of mammalian target of Rapamycin are associated with progesterone …
… MCF-7 breast cancer tumors are associated with hyperactivation of the mTOR pathway: therapeutic implications for combination therapy with Rapamycin
Rapamycin, Mycophenolate Mofetil, Methylprednisolone, and Cytotoxic T-Lymphocyte–Associated Antigen 4 Immunoglobulin–Based Conditioning Regimen to Induce …
Long-term effects of Rapamycin treatment on insulin mediated phosphorylation of Akt/PKB and glycogen synthase activity
A fast and simple method to prepare the FKBP-Rapamycin binding domain of human target of Rapamycin for NMR binding assays
Dentritic cell derived IL-18 production is inhibited by Rapamycin and sanglifehrin A, but not cyclosporine A
Hypoxia-induced hypomyelination in the developing brain is mammalian target of Rapamycin-4E-binding protein-1 signaling dependent
Combination of Nab-Rapamycin and Perifosine Induces Synergistic Cytotoxicity and Antitumor Activity Via Autophagy and Apoptosis in Multiple Myeloma (MM)
Effects of mTOR inhibitor Rapamycin on Smad 3 protein and collagen type I expression in rat myocardial fibroblasts infected with coxsackie virus B 3
Synergistic effect of Rapamycin (RPM) and PD98059 on cell cycle and mTOR signal transduction in human colorectal cancer cells
A phase II study of mammalian target of Rapamycin (mTOR) inhibitor RAD001 plus imatinib mesylate (IM) in patients with previously treated advanced renal carcinoma …
Influence of Rapamycin on rat macrophage viability and chemotaxis toward allogenic pancreatic islet supernates
Orally administered Rapamycin does not modify rat aortic vascular tone
Rapamycin inhibits the growth of cholangiocarcinoma cells in vitro
Sirolimus (Rapamycin) induced proteinuria in a patient undergoing allogeneic hematopoietic stem cell transplant
Induction effect of Rapamycin combined paclitaxel on apoptosis of ovarian cancer cell lines A2780 and SKOV3 and the molecular mechanism
Temozolomide combined with the PI3K inhibitor LY294002 or the mTOR inhibitor Rapamycin inhibits melanoma cell growth, survival and invasion
Negative inotropic effect of Rapamycin on isolated human cardiomyocytes
PDE4B Activity Controls Glucorticoid and Rapamycin Effects in DLBCL.
Effects of Rapamycin on intracellular cholesterol homeostasis of glomerular mesangial cell in the presence of interleukin-1β
TOR (target of Rapamycin) as an anti-cancer target
The expression of mammalian target of Rapamycin in Ishikawa and HEC-1A cells
Cancer and transplantation intersect at the mammalian target of Rapamycin
Expression of connective tissue growth factor in renal interstitial fibrosis after ureteral obstruction and effects of Rapamycin thereupon: experiment with rats
Rapamycin induces Balb/c murine CD4^+ CD25^+ foxp3^+ T cells proliferations
Mannan and peptidoglycan induce COX‐2 protein in human PMN via the mammalian target of Rapamycin
Establishment of a Conjugation System for the Rapamycin Producer Streptomyces hygroscopicus NRRL5491 [J]
Effeet of Rapamycin on mTOR and eIF-4E expression in coxsackievirus B3-induced rat myocardial cells [J]
Effects of Rapamycin on human hepatocellular carcinoma xenografts in nude mice [J]
Induction of PPAR gamma signaling and autophagy as a mechanism mediating acquired Rapamycin resistance in breast cancer models
A drug interaction study of sorafenib (S) and Rapamycin (R) in patients with advanced malignancies
Regression of Pulmonary Lymphangioleiomyomatosis (PLAM)-Associated Retroperitoneal Angiomyolipoma Post–Lung Transplantation With Rapamycin Treatment
Initial use of Rapamycin after kidney transplantation
Combination of CP-751871, a human monoclonal antibody against the IGF-1 receptor, with Rapamycin results in a highly effective therapy for xenografts derived from …
Rapamycin controls multiple signalling pathways involved in cancer cell survival
Phosphatidylinositol 3-kinase/mammalian target of Rapamycin pathway is critical for survival and proliferation of pancreatic cancer stem-like side population cells
Long-term limb allograft survival using a short course of anti-CD45RB monoclonal antibody, LF 15-0195, and Rapamycin in a mouse model
Resveratrol-and Rapamycin-induced Morphological Changes to Human Epithelial Colon Cancer DLD-1 Cells
Phosphoinositide 3-kinase (PI3K) and nutrient sensing mTOR (mammalian target of Rapamycin) pathways control T lymphocyte trafficking
Does the use of paclitaxel or Rapamycin-eluting stent decrease further need for coronary-artery bypass grafting when compared with bare-metal stent?
Preclinical rationale for combination targeted therapy in advanced clear cell renal cell carcinoma (RCC): Abrogation of Rapamycin-mediated induction of AKT …
Effect of Rapamycin on CD4 (+) CD25 (+) regulatory T cells in allo-transplantation tolerance model
Effects of constant magnetic fields on proliferation and migration of endothelial progenitor cells under Rapamycin intervention: experiment with rats
Effect of Rapamycin on expression of origin recognition complex 1 mRNA in vascular smooth muscle cells [J]
The different effects of cyclosporin A and Rapamycin on regulatory CD4+CD25+ T cells: potential relationship with transplant tolerance induction
Experimental study of stent-based delivery of Rapamycin and tirofiban on preventing in-stent thrombosis and restenosis [J]
The clinical contrast investigation of Rapamycin eluting stent between domestic-made and imported [J]
Perivascular delivery of Rapamycin in pluronic gel inhibits neointimal hyperplasia in a rat carotid artery injury model, and the complementary role of carotid …
Effect of Rapamycin on the cell cycle arrest of T lymphocytes
mTOR kinase inhibitors exhibit properties that distinguish them from Rapamycin
… insulin-like growth factor-1 receptor (IGF-1R), enhances the anti-tumor activities of Tarceva in non-small cell lung carcinoma (NSCLC) and Rapamycin in sarcoma cell …
Conversion to Rapamycin in a renal transplant patient with von Hippel-Lindau disease: encouraging results—a case report
Rapamycin to the rescue!
Changes in FDG-PET in response to Rapamycin (R) correlated with Akt pathway inhibition and not with clinical outcome
Rapamycin inhibits proliferation of cells from TSC skin tumors.
Expression of mammalian target of Rapamycin and p70 S6 kinase in rabbit periodontal tissues remodeling during orthodontic tooth movement
Glucose transporter 12 and mammalian target of Rapamycin complex 1 signaling: a new target for diabetes-induced renal injury?
Clinical Application of Mammalian Target of Rapamycin Inhibitor in Kidney Transplantation
SYNERGISTIC EFFECT OF CYCLOSPORINE IN Rapamycin-INDUCE DIABETIC DISEASE: 1937
In Vitro Release of Rapamycin Sustained Eluting Stent Detected by a New Designed Circulating Device
Cause analysis and treatment of Rapamycin-eluting stent thrombosis [J]
Elevated phosphorylated mammalian target of Rapamycin (p-mTOR) expression in human neoplasms
Comparison between the Inhibitory and Cytotoxic Effects of Rapamycin and Paclitaxel on Endothelial Cell Proliferation
Treatment with sodium butyrate and Rapamycin inhibit growth of human cervical cancer cells
Pediatric Preclinical Testing Program (PPTP) evaluation of the mTOR inhibitor Rapamycin
The application of Rapamycin drug-eluting stents in elderly patients with acute myocardial infarction [J]
Effect of mammalian target of Rapamycin inhibitors on neuroblastoma MYCN expression and tumor growth
Efficacy and Safety Study of Rapamycin in Treating Mesangial Proliferative Glomerulonephritis: Analysis of 11 Cases
Effect of Orthodontics on Mammalian Target of Rapamycin and p70 S6 Kinase in Rabbit Periodontal Tissues [J]
Rapamycin affects eIF-4E expression in rat myocardial fibroblasts infected by Coxsackievirus B3
Local applied Rapamycin inhibits intimal hyperplasia in vein graft after CABG
Human monoclonal antibody CP751871, combined with Rapamycin is effective treatment for childhood sarcoma xenografts
P1-084: Mammalian target of Rapamycin (mTOR) inhibition by RAD001 in patients (pts) with reccurent non-small cell lung cancer (NSCLC): Use of 18F …
The application of Rapamycin drug-eluting stents in elderly patients with coronary heart disease [J]
Progress of Rapamycin in hepatocellular carcinoma
Predicting Rapamycin response using pathway profile in a population of genetically engineered hHer2 driven breast tumor model
Effect of conversion from calcineurin inhibitors to Rapamycin on chronic allograft nephropathy
The mTOR inhibitor Rapamycin demonstrates activity against AML in combination with imatinib mesylate and with 5-azacytidine.
Effeet of Rapamycin on mTOR and eIF-4E expression in coxsackievirus B3-induced rat myocardial cells
Combined regimen of Rapamycin and ciclosporin in long-term follow-up in renal allograft recipients
Rapamycin modulates the maturation of rat bone marrow-derived dendritic cells
Experimental study on Rapamycin-batroxobin eluting stent and its prevention of coronary restenosis after angiophaty [J]
Cellular differentiation of Rapamycin, PI3 kinase and TOR kinase inhibitors
Histone deacetylase inhibition with LBH589 inhibits the Rapamycin insensitive Rictor-mTOR (mTORC2) complex and translation initiation factor eIF4E activation in …
9B-6 inhibition of Smooth Muscle Proliferation by Ultrasound-Triggered Release of Rapamycin from Microbubbles
Combination of the VEGF receptor tyrosine kinase sunitinib and the mTOR inhibitor Rapamycin leads to tumor regression in the RENCA model
Toxicology and safety pharmacology of nanoparticle albumin-bound (nab) Rapamycin (ABI-009)
Rapamycin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and induction of apoptosis.
Expression and secretion of VEGF in solid tumor cells is mediated by the mammalian target of Rapamycin (mTOR)
The design and pharmacokinetics in vivo of Rapamycin-PLGA membrane eluting stent [J]
Rapamycin combined with donor bone marrow-derived immature dendritic cells induces mouse skin allograft tolerance
Anti-Proliferative Effect of Rapamycin on Human T Cell Leukemia Cell Line Jurkat by Cell Cycle Arrest and Telomerase inhibition.
Phase I study of gefitinib and Rapamycin in adult patients with recurrent glioblastoma multiforme (GBM)
Rapamycin-induced inhibition of HTLV-I LTR activity is rescued by c-Myb
Effect of RNA interference targeting mammalian target of Rapamycin on the proliferation of vascular smooth muscle cell and the intimal hyperplasia
Anti-Cancer Effects of Rapamycin on U937 Cell Line.
Comparison of inflammatory markers and angiographic outcomes after implantation of Rapamycin and paclitaxel-eluting stents
The roles of mammalian target of Rapamycin (mTOR) and p21 in the autophagy pathway after DNA mismatch repair processing of 6-thioguanine
Molecular determinants of sensitivity to Rapamycin in NSCLC
Dasatinib and Rapamycin synergistically inhibit the proliferation of cells expressing oncogenic KIT kinase via global inhibition of AKT-dependent signaling
Anti-angiogenic activity of Rapamycin in Rapamycin-sensitive and-resistant tumor xenograft models
Mammalian target of Rapamycin impairs insulin’s ability to promote protein kinase B phosphorylation in isolated rat skeletal muscle
Dual Effects of Rapamycin on Immuno-suppression and Tumor inhibition
Rapamycin Inhibits Proliferation of Human Lung Cancer Cell Lines [J]
Combination therapy with Rapamycin and atorvastatin
PI-103, a Dual Inhibitor of Class IA Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin, Has Cytotoxic Activity in T-Cell Acute Lymphoblastic …
The effects of Rapamycin on body weight and insulin resistance in KKAy mice
Cell Proliferation in Multiple Rat Tissues In Vivo is Rapamycin Resistant
The Effect of Rapamycin on Repair of Liver Ischemia/Reperfusion Injury
Genetically engineered murine tumor models for drug response prediction: population based pathway profiles predict response to Rapamycin in a HER2 driven breast …
The effect of Rapamycin on PSA kinetics in men without prostate cancer
Chronic exposure to Rapamycin induces endothelial dysfunction in vitro
Antiproliferative effects of mTOR inhibition with Rapamycin (RAP) either given as a single agent or in combination with carboplatin and paclitaxel in Human Head and …
P158-M Expression of c-kit, p-mTOR and p-NFKappaB in angiolymphoid hyperplasia with eosinophilia: Potential for therapy with imitanib mesylate, Rapamycin and …
Use of Rapamycin to inhibit VEGF for the treatment of primary effusion lymphoma
Rapamycin and CCI-779 suppress the growth of hepatocellular carcinoma cells
Combined effects of Rapamycin and bicalutamide in androgen-dependent and-independent prostate cancer cells
Cholangiocarcinoma cells are selectively susceptible to Rapamycin treatment
The Mammalian Target of Rapamycin and Multiple Myeloma
Rapamycin modulates the eNOS versus shear stress relationship
Effect of Rapamycin on the Proliferation and Apoptosis of Human Leukemia Cell Line HL-60 [J]
EFFECTS OF Rapamycin COMBINED IMMUNOSUPPRESSION ON RENAL FUNCTION AFTER LIVER TRANSPLANTATION
Effects of Rapamycin on proliferation, function and cell-cycle of mouse T lymphocytes in vitro
Mammalian target of Rapamycin and leukemia treatment
Clinical utility of combined administration of Rapamycin and low dose of cyciosporin a in kidney transplantation recipients
Rapamycin Induced Transactivation of EGFR: Implications in the Regulation of Cellular Apoptosis
The mammalian target of Rapamycin (mTOR). Foreword.
Mammalian Target of Rapamycin Activation Impairs
Clinical application of Rapamycin-eluting stent in coronary artery disease
Differential response of mTORC1 and mTORC2 to Rapamycin in Rapamycin-sensitive and-resistant tumor xenograft models
Effect of IGF‐I and Rapamycin on diaphragm muscle atrogenes with malnutrition
Functional genomic identification and validation of Rapamycin response genes using high throughput RNA interference
Rapamycin increases sensitivity to cisplatin in mesothelioma cell lines
Rapamycin inhibition of cell motility is associated with its suppression of synthesis of GTPases
Yeast as a Model to Study the Immunosuppressive and Chemotherapeutic Drug Rapamycin
MANAGEMENT AND LONG-TERM OUTCOMES OF WOUND-HEALING COMPLICATIONS ASSOCIATED WITH Rapamycin: 1108
Rapamycin Augments Akt Activation in In Vitro and In Vivo Models of Cardiac Hypertrophy
The study of anti-proliferation effect of Rapamycin on human breast cancer MCF-7 cells under hypoxia [J]
Rapamycin Reduces CCR5 Density Levels
Rapamycin inhibits Stearoyl-CoA Desaturase 1 expression in breast cancer cell lines.
Overexpression analysis reveals novel growth regulators in the target of Rapamycin signaling pathway
Nutrient Stimulation of eIF4G Phosphorylation, but not PKC is Rapamycin Sensitive in Skeletal Muscle
Role of Rapamycin on cultured human Tenon′ s capsule fibroblasts
Statins and Rapamycin act synergistically to enhance vascular endothelial cytoprotection
Antitumor activity of Rapamycin and octreotide as single agents or in combination in neuroendocrine tumors
Acute Rapamycin Treatment Does Not Improve In Vivo Insulin Action in Ob/Ob or High Fat Fed Mice
Administration of Rapamycin in vivo and in vitro prolonged allograft survival associated with iTregs
THE EFFECT OF LIVER REGENERATION ON Rapamycin PHARMACOKINETICS: 1226
The Clinical Application of Rapamycin Eluting Stent in Elderly Patients with Coronary Heart Disease.
Rapamycin induced “stunning” on FDG PET/CT in pancreatic cancer
Protective Effect of Pretreated Rapamycin on Renal Ischemia-Reperfusion Injury in Rats
Rapamycin impairs skin γδ T cell function resulting in autophagy
Rapamycin aggravates the renal damage in rats with protein overload nephropathy and the protection of losartan
Observation in Safety and Short-term Efficacy of Domestic-made Rapamycin-eluting Stent
Rapamycin Treatment Exacerbates Nutrition-Induced Diabetes in Psammomys obesus.
Rapamycin‐sensitive inhibition of Id1 and p21 in C2C12 myoblasts
Effects of Rapamycin on the Liver Regeneration after Partial Hepatectomy in Rats
Statin therapy, alone or in combination with Rapamycin, does not reverse Monocotaline Pulmonary Arterial Hypertension
Comparative study on clinical outcomes of two kinds of Chinese Rapamycin-eluting stent in patients with coronary artery disease
Rapamycin rescues lactacystin-induced dopaminergic neuron injury in vivo
Modulation of cell cycle progression by combined Rapamycin-octreotide treatment in pituitary tumor cells
Local application of Rapamycin inhibits neointimal hyperplasia in experimental vein grafts
Histologic Changes After Intravitreal Injection of Rapamycin and Bevacizumab in a Porcine Model
Bevacizumab and Rapamycin induce growth suppression in mouse models of hepatocellular carcinoma
Study on the activation of mammalian target of Rapamycin in two endometrial carcinoma cells
Study on the changes of mammalian target of Rapamycin with aging in rat kidneys
290: Rapamycin-generated Th2 cell therapy of established acute murine GVHD requires Th2 cell secretion of both IL-4 and IL-10
Rapamycin CAN AMELIORATE CAN IN RAT ALLOGRAFTS BY AFFECTING RHO/ROCK SIGNAL PATHWAY: 2147
Clinical study on major adverse cardiac events (MACE) rate in patients implanted with Rapamycin-eluting stents [J]
Preclinical evaluation of sorafenib in combination with Rapamycin for the treatment of acute myeloid leukemia (AML)
The Development and Molecular Expression in Mammalian Cells of an HA-Tagged Plasmid Encoding for the Target Of Rapamycin (mTOR)
The Role of Mammalian Target of Rapamycin (mTOR) Inhibitors in the Treatment of Solid Tumors
INFLUENCE OF Rapamycin ON RENAL TUBULAR FUNCTION IN RATS WITH OR WITHOUT CYCLOSPORINE TREATMENT: 1938
Drug eluting stents: long term results in clinical practice. Comparison between Rapamycin and paclitaxel eluting stents
Nucleophosmin Mediates Mammalian Target of Rapamycin
Rapamycin inhibits activation of Stat3 in kidney tissue of IgA nephropathy rats
Leukemia Induced by Altered TRK-Signaling Is Sensitive to Rapamycin Treatment in a Preclinical Model
Mechanisms of urokinase mediated activation of the mammalian target of Rapamycin (mTOR)
UROKINASE‐INDUCED SMOOTH MUSCLE CELL MIGRATION INVOLVES THE MAMMALIAN TARGET OF Rapamycin
Anti-inflammatory properties of Rapamycin on leukocyte-endothelial cell interactions following profound hypoperfusion
Contrasting effects of Cyclosporine and Rapamycin in de novo generation of alloantigen-specific regulatory T cells (88.45)
Combination treatment of Rapamycin and low dose irradiation causes cell death in human cancer cells cultured as 3-D spheroids
Rapamycin effects on mTOR signaling in the MCF10AT series of human breast epithelial cells: a model for proliferative breast disease and carcinoma
Anti-inflammatory drugs, sirolimus, and inhibition of target of Rapamycin and its effect on vascular diseases
Effect of Rapamycin in inducing naïve murine effector T cell convert to regulatory T cell
A high throughput assay for mammalian target of Rapamycin (mTOR) kinase activity
Rapamycin INDUCES AUTOPHAGY IN ISLETS: RELEVANCE FOR ISLETS TRANSPLANTATION: 556
Angioplasty stenting with Sirolimus (Rapamycin) eluting stents in type 2 diabetic patients
The Immunosuppressive drugs Rapamycin and FK506 decrease vasodilation by increasing PKCbetai‐mediated phosphorylation of eNOS Thr495
Rapamycin inhibition of the Akt/mTOR pathway blocks select stages of VEGF-A driven angiogenesis in part through the blockade of S6Kinase
Combined Rapamycin-octreotide treatment exerts its superior antiproliferative action by dramatically increasing p27/Kip1 expression
Characterisation of a novel and highly selective kinase inhibitor of the mammalian target of Rapamycin (mTOR)
ST2L upregulation promotes maturation resistance in Rapamycin‐conditioned dendritic cells
P286: Mechanisms of urokinase mediated activation of the mammalian target of Rapamycin (mTOR)
Akt phosphorylates and negatively regulates hnRNPA1-mediated control of cyclin D1 and c-myc translation in response to Rapamycin
Intravitreal Rapamycin and Bevacizumab Inhibits VEGF Expression in a Swine Model of Neovascularization
Acute activation of the mammalian target of Rapamycin complex 1 does not impair in vivo insulin action in mice
Combined Therapeutic Effects of Vinblastine and Rapamycin on Human Neuroblastoma Growth, Apoptosis, and Angiogenesis
Cell cycle proteins and hTERT telomerase mRNA expression are independent targets of Rapamycin in ovarian cancer cell lines
Re-evaluating the roles of proposed modulators of mammalian target of Rapamycin complex 1 (mTORC1) signaling
P39. Rapamycin and the downstream target of mTOR, ribosomal protein L29 (RPL29), regulate prostate cancer cell growth and bone metastatic potential
Thymidine phosphorylase-related migratory effect of cancer cell is abrogated by m-TOR inhibitor Rapamycin
Curcumin inhibition of the mammalian target of Rapamycin signaling pathway
Synergistic combinations of a novel PI3 Kinase inhibitor with Erlotinib and Rapamycin and the associated effects on downstream signalling
Evaluation of the mTOT inhibitor, Rapamycin in dogs with spontaneously derived osteosarcoma: A focus on preclinical pharmacokinetics and pharmacodynamics
Activation of Mammalian Target of Rapamycin (mTOR) in Esophageal Squamous Cell Carcinona Cell Line [J]
The mammalian target of Rapamycin (mTOR) signaling in thymic lymphomagenesis in Atm-/-mice
Rapamycin-induced remission of Kaposi’s sarcoma is not associated with expansion of cytotoxic T-lymphocyte subsets
The Mammalian Target of Rapamycin Plays a Critical Role in the Development of Cardiac Hypertrophy in Spontaneously Hypertensive Rats
Inhibitory effect of Rapamycin and dexamethasone on production of IL-17 and IFN-c in Vogt–Koyanagi–Harada patients
Targeted therapy for osteosarcoma using 17AAG and Rapamycin: Identification of new targets by gene microarray profiling and miRNA
Divergent Roles of PI3K and Akt in Rapamycin-induced Cardioprotection against Ischemia-Reperfusion Injury
The Combination of the mTOR Inhibitor Rapamycin and Protein Kinase C Inhibitors Produces Marked Synergistic Anti-Myeloma Effects.
Expansion of Functional Polyclonal Human T-regulatory Cell Lines Using Artificial Antigen Presenting Cells and Rapamycin.(B159)
Sepsis associated platelet dysfunction & Rapamycin sensitive pathway of lipopolysaccharide signaling
COMPARISON OF Rapamycin VS. FK506 ON EXPRESSION OF CYTOPROTECTIVE GENES IN THE RAT-KIDNEY ALLOGRAFTS UNDERGOING CHRONIC …
Synergistic effect of Rapamycin and Casodex in inhibition of cell growth and survival as well as AR transcriptional activity in androgen dependent and independent …
Clenbuterol antagonizes Rapamycin-induced atrophy in rat soleus muscle
Ocular Toxicity and Distribution of Intravitreal and Subconjunctival Rapamycin in Horses
Rapamycin Withdrawal versus Delayed Initiation: Thrombosis vs. Suppression of Neointimal Hyperplasia after Vascular Injury
Rapamycin prevents cadmium-induced neuronal apoptosis by suppression of MAPK and mTOR pathways
Changes in gene expression profile after Rapamycin treatment of ErbB2-positive/ErbB2-negative breast carcinoma in organ culture
Dual inhibition of the Akt pathway by Rapamycin and Perifosine induces synergistic anti-tumor activity in multiple myeloma
Clinical Benefits of Rapamycin-Eluting Stent Made in China Appliance and Investigation in Patients with Acute Coronary Syndromes
Rapamycin Causes Reversible Cell Cycle Slowing, Rather Than Cell Cycle Arrest, in Myeloid and Lymphoid Cell Lines and in Acute Leukemia Cells
Effective inhibition of tumor growth in patient-derived xenografts of hepatocellular carcinoma by Rapamycin and bevacizumab
Protein kinase C (μ, θ, ϵ)-dependent Bad phosphorylation is an important signaling pathway in IGF-I rescue of sarcoma cells from Rapamycin-induced apoptosis
Enzastaurin inhibits growth of head and neck cancer cells and xenografts and synergizes with Rapamycin
Binding of novel Rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities
Combination of somatostatin analogues with Rapamycin analogues as a potential pharmaceutical treatment for non-functioning pituitary adenomas
Mammalian Target of Rapamycin (mTOR) is Essential for Murine Heart Development
A spontaneous pancreatic tumor model for monitoring pancreatic lesion and response to Rapamycin treatment through bioluminescence imaging
Targeted therapy for osteosarcoma using 17AAG and Rapamycin: Identification of new targets using Gene Microarray profiling and MiRNA
Rapamycin regulates synthesis of transforming growth factor-beta1 and extracellular matrix in arterial neointimal smooth muscle cells
Utilization of Meso Scale Discovery ELISA technology to quantitate the in vivo pharmacodynamic effects of Rapamycin treatment on the AKT pathway
Rapamycin blocks leucine‐induced protein synthesis by suppressing mTORC1 activation in skeletal muscle of neonatal pigs
Rapamycin IS LESS FIBROGENIC THAN FK506 IN RAT MODEL OF CHRONIC ALLOGRAFT NEPHROPATHY: 2144
Identification and characterization of novel positive regulators of the Target of Rapamycin (TOR) pathway in Drosophila melanogaster
The Role of Mammalian Target of Rapamycin in the Regulation of Amino Acid Transporters in the Human Placenta
Rapamycin, mTOR inhibitor, a potent inhibitor for the cell growth and proliferation by p21-dependent mitotic arrest in human gastric cancers
Role of mechanistic Target of Rapamycin (mTOR) signaling in the crustacean molting gland
… Scale Expansion of Human Dendritic Cells with Regulatory Function from Peripheral Blood Monocytes Employing Leukapheresis and Rapamycin for Clinical Trials.
Angioplasty stenting with Sirolimus (Rapamycin) eluting stents in type 2 diabetic patients Angioplastia con stents liberadores de rapamicina en diabéticos tipo 2 …
Rapamycin prevents tobacco-carcinogen induced lung tumorigenesis and selectively reduces lung-associated Foxp3 positive cells
Clinical observation of Rapamycin Eluting Stent in acute ST-segment elevated myocardial infarction between domestic and imported product
Targeted therapy for osteosarcoma using 17AAG and Rapamycin: identification of new targets using l Gene microarray profiling and proteomics
EARLY IMMUNOSUPPRESSION WEANING AFTER CADAVER LIVER TRANSPLANTATION USING ATG INDUCTION AND Rapamycin: 358
inhibition effect of Rapamycin on acute graft-versus-host disease after allogeneic bone marrow transplantation in a murine model
Dual inhibition of phosphoinositide 3-kinase and mammalian target of Rapamycin as a novel therapeutic approach in human ovarian carcinoma
A small molecule inhibitor against kinase domain of mammalian target of Rapamycin (mTOR) causes autophagic cell death in glioblastoma
Effects of Imatinib and Rapamycin on the mTOR/S6 Signal Transduction Pathway in CD33+ Cell of CML
mTOR inhibitors Rapamycin and RAD001 (Everolimus) induce antiproliferative effects in GH3 cell line and human pituitary adenomas
PNEUMONITIS FROM INHIBITORS OF THE MAMMALIAN TARGET OF Rapamycin (mTOR) IN PATIENTS WITH METASTATIC CANCER
Targeted therapy for osteosarcoma using 17AAG and Rapamycin: Characterization of induced apoptosis and inhibition of mTOR and AKT/MAP kinase pathways
Blockage of mTOR signaling pathway by Rapamycin contributes to inhibition of tumor cell proliferation in ALK-positive lymphoid cell strains
The Yaa locus Confers Apoptosis, NF-κB and Rapamycin Signaling Resistance Through Multiple Receptors in C57BL/6J Mice (129.12)
Domestic versus foreign Rapamycin-eluting stents for emergency percutaneous coronary intervention in elder patients with acute myocardial infarction: Randomized …
Tumor suppressor gene ARHI (DIRAS3) is required for spontaneous and Rapamycin-induced autophagy in normal and ovarian cancer cells
Complete Responses in Patients with Autoimmune Lymphoproliferative Syndrome (ALPS) Using the mTOR Inhibitor Sirolimus (Rapamycin)
Signaling Downstream of Mammalian Target of Rapamycin Complex 1 (mTORC1) is Derepressed Following Treatment with L‐Asparaginase in the Liver of GCN2 …
MESENCHYMAL STEM CELLS ATTENUATE ACUTE REJECTION AND SYNERGIZE WITH Rapamycin LEADING TO CARDIAC ALLOGRAFT TOLERANCE: 382
inhibition of the mammalian target of Rapamycin (mTOR) for the chemoprevention of tobacco-carcinogen induced lung tumorigenesis
mTORC1 inhibition with Rapamycin or LY294002 alone but not in combination leads to AKT phosphorylation via mTORC2 in melanoma cells
Corrigendum to “Low-dose oral Rapamycin treatment reduces fibrogenesis, improves liver function, and prolongs survival in rats with established liver cirrhosis”[J …
FK506 VERSUS Rapamycin HAVE DIFFERENT EFFECTS ON EXPRESSION OF ANGIOPOIETINS1, 2 AND TIE2 IN RAT RENAL ALLOGRAFT WITH CAN: 1925
Combination Therapy Utilizing Murine Anti-Thymocyte Globulin (ATG) and Rapamycin for the Reversal of Overt Type 1 Diabetes in NOD Mice.
Rapamycin REDUCES VASCULAR INJURY BUT EXACERBATES PROTEINURIA IN ASSOCIATION WITH inhibition OF VEGF AND VEGF-R IN CHRONIC …
… Inhibitor Causes Growth inhibition, Cell Cycle Arrest, Apoptosis and Autophagic Cell Death in Mantle Cell Lymphoma Cell Lines: A Distinct Profile from Rapamycin.
Rapamycin PREFERENTIALLY BLOCKS THE EXPANSION OF POTENTIALLY TOLEROGENIC PLASMACYTOID DENDRITIC CELLS IN VIVO: 2217
Rapamycin DECREASES CHOLESTEROL EFFLUX AND ABCA1 PROTEIN EXPRESSION WITHIN THP-1 MACROPHAGES: 1931
TARGETED DELIVERY OF Rapamycin TO DENDRITIC CELLS USING BIODEGRADABLE MICROPARTICLES IS HIGHLY EFFECTIVE IN SUPPRESSING THEIR …
Mating Stimulates Protein Phosphorylation and Synthesis Via Rapamycin-and Wortmannin-Sensitive Pathways in the Male Accessory Glands of D. melanogaster
Dietary induced insulin resistance is independent of mammalian target of Rapamycin complex 1 (mTORC1) activity in skeletal muscle of mice
191: Rapamycin inhibits endothelial cell recovery after hypoxic injury
Enhancement of Mammalian Target of Rapamycin Complex-2 (TORC2) Kinase Activity by Fructose-2, 6-Bisphosphate.
Effect of Rapamycin/Curcumin Co-Loaded Poly (Lactide-Co-Glycolide) Films on Blood Compatibility and Vascular Smooth Muscle Cell Proliferation
COMBINE TGF-BETA/FC AND Rapamycin FOR REGULATORY T CELLS GENERATION AND ALLOGRAFT TOLERANCE INDUCTION.: 728
The Wnt Agonist, SKL2020 Inhibits Neointimal Hyperplasia but Facilitates Re-Endothelialization, When Treated with Rapamycin in Porcine Coronary Artery Stent …
IL-1β-DRIVEN ST2 EXPRESSION PROMOTES MATURATION RESISTANCE IN Rapamycin-CONDITIONED DENDRITIC CELLS: 643
PRO-TOLEROGENIC PROPERTIES OF Rapamycin THAT FAVOR INDEFINITE HEART ALLOGRAFT SURVIVAL MEDIATED BY REGULATORY T CELLS.: 27
Mechanism of luteolin-induced apoptosis through suppressing p21 (WAF1/CIP1) expression with Rapamycin in HER2-overexpressing cancer cells
… ALLOGRAFT SURVIVAL IN UNMANIPULATED HOSTS BY POST-TRANSPLANT INFUSION OF DONOR-SPECIFIC REGULATORY T CELLS AND Rapamycin: 655
Role of the mammalian Target of Rapamycin (mTOR) Complex 1 signaling in beta‐adrenergic‐stimulated triacylglycerol (TAG) lipolysis and free fatty acid (FFA) …
A phase I study of the mTOR inhibitor sirolimus (Rapamycin) in combination with nanoparticle albumin-bound paclitaxel (ABI-007, abraxane) in advanced solid cancers
IMPACT OF IMMUNOSUPPRESSION ON UV-INDUCED SKIN-TUMORS IN MICE: Rapamycin IMPAIRS TUMOR OUTGROWTH AND SHIFTS THE MUTATION …
Dexamethasone represses signaling through mammalian target of Rapamycin (mTOR) in muscle cells by enhancing expression of REDD1
inhibition of mammalian target of Rapamycin (mTOR) induces phosphatidylinositol 3 kinase-dependent and Mnk-mediated eIF4E phosphorylation
Rapamycin, mTOR Inhibitor, a Potent Cell Growth and Proliferation Inhibitor by p21-Dependent Mitotic Arrest in Human Gastric Cancers
Rapamycin PROMOTES THE ENRICHMENT OF CD4+ CD25HIFOXP3+ T REGULATORY CELLS FROM NAIVE CD4+ T CELLS OF BABOON THAT SUPPRESS …
… with drug eluting stents but with significant cost saving: long term follow up results from the randomized, controlled ORAR III (Oral Rapamycin in Argentina) Study
PD2-4 Survival Advantage of Temsirolimus Validates a Role for Mammalian Target of Rapamycin (mTOR) in the Biology of Advanced Renal Cell Carcinoma
P3-026: A novel Bayesian dose-escalation Phase Ib study design investigating combination of the mammalian target of Rapamycin (mTOR) inhibitor RAD001 with …
Cell cycle arrest and suppression of the Akt/mammalian target of Rapamycin signaling mediated by yuanhuadine, a daphnane diterpenoid, isolated from Daphne …
… Smooth Muscle Cell Proliferation and Intimal Expansion by Phosphatidylinositol 3-Kinase–Dependent Mammalian Target of Rapamycin Raptor Complex 1 …
155. Tumor Necrosis In Vivo Caused by a Novel Combination of Sorafenib and Rapamycin: Targeting the RAS and Motor Pathways ION Hepatocellular Carcinoma
342: Rapamycin Prevents GVHD in Mouse Model through Novel Mechanism: Increase in Regulatory T cells
… downregulates acetyl-CoA carboxylase alpha and fatty acid synthase by activating AMP-activated protein kinase and suppressing the mammalian target of Rapamycin …
Glycogen Synthase Kinase-3 (GSK-3) Signaling to Mammalian Target of Rapamycin (mTOR) Regulates DNA Synthesis and Cell Cycle Progression in Rodent and …
THROMBOSPONDIN-1 (TSP-1) MEDIATES THE ANTI ANGIOGENIC AND IMMUNOMODULATORY EFFECTS OF Rapamycin ON PANCREATIC ISLET …
53: Rapamycin Partially Overcomes the in vitro Protective Effect of M2–10B4 Mesenchymal Stromal Cells (MSC) to Murine mCGPR/+ Acute Promyelocytic Leukemic …
… CXC Chemokine Receptor 4 (CXCR4) by Hypoxia and the Phosphatidylinositol 3‐Kinase (PI‐3‐K)/Mammalian Target of Rapamycin (mTOR) Signaling Pathway
234: Rapamycin generated donor Th2/Tc2 cells prevent graft rejection by inhibition of alloreactivity and not by deletion of alloreactive T cells
FoxP3 Mediated Induction of Pim 2 Allows T Regulatory Cells to Preferentially Expand in Rapamycin
The Novel Glycolysis Inhibitor, 3-BrOP, Has Broad Activity Against Acute Lymphoblastic Leukemias and Potentiates Methotrexate and Rapamycin.
… -selective oncolytic adenovirus OBP-405 induces autophagic cell death and enhances the antitumor effect of temozolomide and Rapamycin on glioblastoma cells in …
… regulatory (CD4+ CD25+ CD127LowFOXP3+) cells to high purity by inhibiting expansion of CD4+ CD25+ CD127HighFOXP3-conventional T cells with Rapamycin
Late stage efficacy and regulated gene expression profiles by 5-aza-dC, valproic acid, suberoylanilide hydroxamic acid, and Rapamycin in mouse lung tumorigenesis
720: inhibition of Proliferation by Rapamycin in RAT Bladder Smooth Muscle Cells
307: Initial selection of high affinity CD25+ cells increases the purity of CD4+ CD25+ Foxp3+ T regulatory cells expanded in medium containing Rapamycin
518: Medium term renal function of pediatric heart transplant patients on reduced calcineurin inhibitor and Rapamycin
Automated quantitative analysis of AKT/mTOR pathway in patients treated with nanoparticle albumin-bound paclitaxel (ABI-007, Abraxane) and (sirolimus) Rapamycin
51: Rapamycin and its influence on arterial vascular function after short-term incubation
336: Relative Contribution of CD127 Negative Selection, Rapamycin, and TGF-β to the Generation of Human Regulatory T Cells that Inhibit Alloreactivity via Dendritic …
An ATP-competitive mammalian target of Rapamycin inhibitor reveals Rapamycin-resistant functions of mTORC1
Rapamycin decelerates cellular senescence
Structure of the human mTOR complex I and its implications for Rapamycin inhibition
Delayed correlation of mRNA and protein expression in Rapamycin-treated cells and a role for Ggc1 in cellular sensitivity to Rapamycin
Rapamycin inhibits mTORC1, but not completely
Mammalian target of Rapamycin: discovery of Rapamycin reveals a signaling pathway important for normal and cancer cell growth
Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Mechanisms of life span extension by Rapamycin in the fruit fly Drosophila melanogaster
Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson’s Disease
Targeting mTOR with Rapamycin: one dose does not fit all
The role of the mammalian target of Rapamycin (mTOR) in renal disease
Mammalian target of Rapamycin (mTOR): conducting the cellular signaling symphony
Potential use of Rapamycin in HIV infection
Targeting mTOR globally in cancer: thinking beyond Rapamycin
The complexes of mammalian target of Rapamycin
The mammalian target of Rapamycin: linking T cell differentiation, function, and metabolism
Not all substrates are treated equally: Implications for mTOR, Rapamycin-resistance, and cancer therapy
Rapamycin-induced phosphaturia
The mammalian target of Rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy
Mammalian target of Rapamycin complex 1: signalling inputs, substrates and feedback mechanisms
Rapamycin administration in humans blocks the contraction‐induced increase in skeletal muscle protein synthesis
Rapamycin extends maximal lifespan in cancer-prone mice
Active-site inhibitors of mTOR target Rapamycin-resistant outputs of mTORC1 and mTORC2
Nutrient-dependent regulation of autophagy through the target of Rapamycin pathway
Biosynthesis of Rapamycin and its regulation: past achievements and recent progress
inhibition of mTOR by Rapamycin abolishes cognitive deficits and reduces amyloid-β levels in a mouse model of Alzheimer’s disease
SIRT1 negatively regulates the mammalian target of Rapamycin
Targeting mammalian target of Rapamycin by Rapamycin prevents tumor progression in an oral-specific chemical carcinogenesis model
Characterization of the Rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis
Rapamycin and quasi-programmed aging: Four years later
A versatile role of mammalian target of Rapamycin in human dendritic cell function and differentiation
Autophagy is required for extension of yeast chronological life span by Rapamycin
Rapid inactivation of proteins by Rapamycin-induced rerouting to mitochondria
Discovery of GSK2126458, a highly potent inhibitor of PI3K and the mammalian target of Rapamycin
Ku-0063794 is a specific inhibitor of the mammalian target of Rapamycin (mTOR)
Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss
GOLPH3 modulates mTOR signalling and Rapamycin sensitivity in cancer
Molecular interplay between mammalian target of Rapamycin (mTOR), amyloid-β, and Tau: effects on cognitive impairments
A Rapamycin-sensitive signaling pathway is essential for the full expression of persistent pain states
Resveratrol and Rapamycin: are they anti‐aging drugs?
Metformin and Rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells
Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of Rapamycin
Rapamycin protects against rotenone-induced apoptosis through autophagy induction
Protein synthesis is resistant to Rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia
Rapamycin reduces seizure frequency in tuberous sclerosis complex
Pharmacological inhibition of the mammalian target of Rapamycin pathway suppresses acquired epilepsy
Preliminary characterization of oral lesions associated with inhibitors of mammalian target of Rapamycin in cancer patients
TORC-specific phosphorylation of mammalian target of Rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2
Total synthesis of Rapamycin
Targeted inhibition of mammalian target of Rapamycin signaling inhibits tumorigenesis of colorectal cancer
AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of Rapamycin kinase inhibitor with in vitro and in vivo antitumor activity
Tti1 and Tel2 are critical factors in mammalian target of Rapamycin complex assembly
The mTOR pathway is highly activated in diabetic nephropathy and Rapamycin has a strong therapeutic potential
Role for mammalian target of Rapamycin complex 1 signaling in neuroadaptations underlying alcohol-related disorders
Dual inhibition of Akt/mammalian target of Rapamycin pathway by nanoparticle albumin-bound–Rapamycin and perifosine induces antitumor activity in multiple …
Long-term Rapamycin therapy in the Han: SPRD rat model of polycystic kidney disease (PKD)
Delivery of Rapamycin to dendritic cells using degradable microparticles
Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and Rapamycin in vivo
CDC25B mediates Rapamycin-induced oncogenic responses in cancer cells
Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with Rapamycin
Curcumin disrupts the Mammalian target of Rapamycin-raptor complex
HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and Rapamycin combination therapy
Chronic Rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose …
Recent advances in the chemistry, biosynthesis and pharmacology of Rapamycin analogs
inhibition of target of Rapamycin signaling and stress activate autophagy in Chlamydomonas reinhardtii
Akt signals through the mammalian target of Rapamycin pathway to regulate CNS myelination
Beneficial effects of Mammalian target of Rapamycin inhibition on left ventricular remodeling after myocardial infarction
Mammalian target of Rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways
Activation of the mammalian target of Rapamycin (mTOR) is essential for oligodendrocyte differentiation
The Rapamycin-sensitive phosphoproteome reveals that TOR controls protein kinase A toward some but not all substrates
Sorafenib and Rapamycin induce growth suppression in mouse models of hepatocellular carcinoma
Mammalian target of Rapamycin: hitting the bull’s-eye for neurological disorders
Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies
Mammalian target of Rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: from tuberous sclerosis to common acquired epilepsies
inhibition of the mammalian target of Rapamycin (mTOR) in advanced pancreatic cancer: results of two phase II studies
A pharmacodynamic study of Rapamycin in men with intermediate-to high-risk localized prostate cancer
Bone growth during Rapamycin therapy in young rats
Regulation of placental amino acid transporter activity by mammalian target of Rapamycin
Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity
Mammalian target of Rapamycin regulates miRNA-1 and follistatin in skeletal myogenesis
Topical Rapamycin: a novel approach to facial angiofibromas in tuberous sclerosis
New inhibitors of the mammalian target of Rapamycin signaling pathway for cancer
Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses
Mammalian target of Rapamycin inhibitors and their potential role in therapy in leukaemia and other haematological malignancies
Integration of general amino acid control and target of Rapamycin (TOR) regulatory pathways in nitrogen assimilation in yeast
Specific roles of Target of Rapamycin in the control of stem cells and their progeny in the Drosophila ovary
Down-regulation of Akt/mammalian target of Rapamycin signaling pathway in response to myostatin overexpression in skeletal muscle
Infusion of mesenchymal stem cells and Rapamycin synergize to attenuate alloimmune responses and promote cardiac allograft tolerance
Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia
Rapamycin inhibition of the Akt/mTOR Pathway Blocks Select Stages of VEGF-A164–Driven Angiogenesis, in Part by Blocking S6Kinase
Rapamycin Protects Against High Fat Diet–Induced Obesity in C57BL/6J Mice
Rapamycin regulates stearoyl CoA desaturase 1 expression in breast cancer
Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of Rapamycin in neonatal hypoxia-ischemia
Overexpression of phosphorylated mammalian target of Rapamycin predicts lymph node metastasis and prognosis of chinese patients with gastric cancer
Mammalian target of Rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves
Rapamycin promotes β-amyloid production via ADAM-10 inhibition
Differential responses of human regulatory T cells (Treg) and effector T cells to Rapamycin
Monitoring mammalian target of Rapamycin (mTOR) activity
The efficacy of the novel dual PI3-kinase/mTOR inhibitor NVP-BEZ235 compared with Rapamycin in renal cell carcinoma
Mammalian target of Rapamycin is a critical regulator of cardiac hypertrophy in spontaneously hypertensive rats
Treatment with Rapamycin prevents fibrosis in tight‐skin and bleomycin‐induced mouse models of systemic sclerosis
Mammalian target of Rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage
Regulation of RNA polymerase III transcription involves SCH9-dependent and SCH9-independent branches of the target of Rapamycin (TOR) pathway
Mammalian target of Rapamycin controls dendritic cell development downstream of Flt3 ligand signaling
Comparison of human and rat uterine leiomyomata: identification of a dysregulated mammalian target of Rapamycin pathway
Long‐term administration of Rapamycin reduces adiposity, but impairs glucose tolerance in high‐fat diet‐fed KK/HlJ mice
Rapamycin inhibits hepatic fibrosis in rats by attenuating multiple profibrogenic pathways
Regulation of insulin-like growth factor–mammalian target of Rapamycin signaling by microRNA in childhood adrenocortical tumors
Rapamycin prevents transforming growth factor-α–induced pulmonary fibrosis
Participation of mammalian target of Rapamycin complex 1 in Toll-like receptor 2–and 4–induced neutrophil activation and acute lung injury
Use of Rapamycin in the induction of tolerogenic dendritic cells
Rapamycin versus methotrexate in early diffuse systemic sclerosis: Results from a randomized, single‐blind pilot study
Insights into the domain and repeat architecture of target of Rapamycin
A novel mouse model of inflammatory bowel disease links mammalian target of Rapamycin-dependent hyperproliferation of colonic epithelium to inflammation …
Nutrient availability and lactogenic hormones regulate mammary protein synthesis through the mammalian target of Rapamycin signaling pathway
The mammalian target of Rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system
… irinotecan and Rapamycin combination toward colon cancer cells in vivo and in vitro is mediated through cooperative modulation of the mammalian target of Rapamycin …
Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability
Rapamycin-resistant mTORC1 kinase activity is required for herpesvirus replication
Mammalian target of Rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade
Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of Rapamycin pathway
Critical roles for mTORC2-and Rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells
inhibition of the mammalian target of Rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy
Oral Rapamycin attenuates inflammation and enhances stability of atherosclerotic plaques in rabbits independent of serum lipid levels
Myxoma virus virotherapy for glioma in immunocompetent animal models: optimizing administration routes and synergy with Rapamycin
inhibition of histone deacetylase overcomes Rapamycin-mediated resistance in diffuse large B-cell lymphoma by inhibiting Akt signaling through mTORC2
Rapamycin promotes the osteoblastic differentiation of human embryonic stem cells by blocking the mTOR pathway and stimulating the BMP/Smad pathway
Synergistic effect of Rapamycin and cisplatin in endometrial cancer cells
Activation of mammalian target of Rapamycin controls the loss of TCRζ in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation
Mammalian target of Rapamycin activation underlies HSC defects in autoimmune disease and inflammation in mice
Uremic cardiac hypertrophy is reversed by Rapamycin but not by lowering of blood pressure
Testosterone induces cardiomyocyte hypertrophy through mammalian target of Rapamycin complex 1 pathway
Rapamycin in islet transplantation: friend or foe?
Mammalian target of Rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR
Rapamycin, unlike cyclosporine A, enhances suppressive functions of in vitro-induced CD4+CD25+ Tregs
Mammalian target of Rapamycin signaling is crucial for joint destruction in experimental arthritis and is activated in osteoclasts from patients with rheumatoid arthritis
Rapamycin has dual opposing effects on proteinuric experimental nephropathies: is it a matter of podocyte damage?
Distinct roles for mammalian target of Rapamycin complexes in the fibroblast response to transforming growth factor-β
Expression of an activated mammalian target of Rapamycin (mTOR) in gastroenteropancreatic neuroendocrine tumors
The somatostatin analogue octreotide confers sensitivity to Rapamycin treatment on pituitary tumor cells
Rapamycin regulates Akt and ERK phosphorylation through mTORC1 and mTORC2 signaling pathways
Rapamycin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and induction of apoptosis
ATP-competitive inhibitors of the mammalian target of Rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines
Gastric mammalian target of Rapamycin signaling regulates ghrelin production and food intake
The potential benefits of Rapamycin on renal function, tolerance, fibrosis, and malignancy following transplantation
Target of Rapamycin signaling in leukemia and lymphoma
Rapamycin inhibits relapsing experimental autoimmune encephalomyelitis by both effector and regulatory T cells modulation
Targeted inhibition of mammalian target of Rapamycin for the treatment of advanced renal cell carcinoma
Target of Rapamycin (TOR) mediates the transduction of nutritional signals into juvenile hormone production
Rapamycin activates autophagy and improves myelination in explant cultures from neuropathic mice
Phase II trial of the oral mammalian target of Rapamycin inhibitor everolimus in relapsed or refractory Waldenström macroglobulinemia
Mammalian target of Rapamycin (mTOR) regulates cellular proliferation and tumor growth in urothelial carcinoma
The novel orally bioavailable inhibitor of phosphoinositol-3-kinase and mammalian target of Rapamycin, NVP-BEZ235, inhibits growth and proliferation in multiple …
Mammalian target of Rapamycin: biological function and target for novel anticancer agents
Mammalian target of Rapamycin signaling activation patterns in neuroendocrine tumors of the lung
inhibition of mammalian target of Rapamycin as a therapeutic strategy in the management of bladder cancer
Randomised trial of three Rapamycin-eluting stents with different coating strategies for the reduction of coronary restenosis: 2-year follow-up results
inhibition of mammalian target of Rapamycin is required for optimal antitumor effect of HER2 inhibitors against HER2-overexpressing cancer cells
Perifosine inhibits mammalian target of Rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy
The effect of Rapamycin on bone growth in rabbits
Rapamycin pharmacokinetic and pharmacodynamic relationships in osteosarcoma: a comparative oncology study in dogs
Efficacy of systemically administered oncolytic vaccinia virotherapy for malignant gliomas is enhanced by combination therapy with Rapamycin or cyclophosphamide
Rapamycin induces transactivation of the EGFR and increases cell survival
Mammalian target of Rapamycin inhibitors Rapamycin and RAD001 (everolimus) induce anti-proliferative effects in GH-secreting pituitary tumor cells in vitro
Adiponectin modulates C-jun N-terminal kinase and mammalian target of Rapamycin and inhibits hepatocellular carcinoma
B55β-associated PP2A complex controls PDK1-directed myc signaling and modulates Rapamycin sensitivity in colorectal cancer
High entrapment efficiency of chitosan/polylactic acid/tripolyphotspate nanosized microcapsules for Rapamycin by an emulsion-evaporation approach
Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation, and mammalian target of Rapamycin inhibition
Chemical genetics screen for enhancers of Rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase
Immune regulation by Rapamycin: moving beyond T cells
First report on a series of HIV patients undergoing Rapamycin monotherapy after liver transplantation
… leucine content of a complete meal directs peak activation but not duration of skeletal muscle protein synthesis and mammalian target of Rapamycin signaling in rats
Rapamycin reduces intrahepatic alpha-1-antitrypsin mutant Z protein polymers and liver injury in a mouse model
Rapamycin inhibits in vitro growth and release of angiogenetic factors in human bladder cancer
Mammalian target of Rapamycin signaling modulates photic entrainment of the suprachiasmatic circadian clock
The tuberous sclerosis proteins regulate formation of the primary cilium via a Rapamycin-insensitive and polycystin 1-independent pathway
Phospho-mTOR and phospho-4EBP1 in endometrial adenocarcinoma: association with stage and grade in vivo and link with response to Rapamycin treatment in vitro
Different effects of FK506, Rapamycin, and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets
Downregulation of Akt/mammalian target of Rapamycin pathway in skeletal muscle is associated with increased REDD1 expression in response to chronic hypoxia
Dual targeting of AKT and mammalian target of Rapamycin: a potential therapeutic approach for malignant peripheral nerve sheath tumor
Mammalian target of Rapamycin in spinal cord neurons mediates hypersensitivity induced by peripheral inflammation
Effect of Rapamycin, an mTOR inhibitor, on radiation sensitivity of lung cancer cells having different p53 gene status
Leptin modulates the survival of autoreactive CD4+ T cells through the nutrient/energy-sensing mammalian target of Rapamycin signaling pathway
… skeletal muscle protein synthesis via an indirect mechanism involving endothelial-dependent vasodilation and mammalian target of Rapamycin complex 1 signaling
Signaling events downstream of mammalian target of Rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor …
A phase I study of the mammalian target of Rapamycin inhibitor sirolimus and MEC chemotherapy in relapsed and refractory acute myelogenous leukemia
Morpholine derivatives greatly enhance the selectivity of mammalian target of Rapamycin (mTOR) inhibitors
Intravesical delivery of Rapamycin suppresses tumorigenesis in a mouse model of progressive bladder cancer
Complex regulation of mammalian target of Rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status
Mammalian target of Rapamycin regulates vascular endothelial growth factor–dependent liver cyst growth in polycystin‐2–defective mice
Rapamycin sensitizes T-ALL cells to dexamethasone-induced apoptosis
Generation of high-yield Rapamycin-producing strains through protoplasts-related techniques
An expeditious route to fluorinated Rapamycin analogues by utilising mutasynthesis
Mechanisms involved in the enhancement of mammalian target of Rapamycin signalling and hypertrophy in skeletal muscle of myostatin-deficient mice
Mammalian target of Rapamycin and diabetes: what does the current evidence tell us?
Mammalian target of Rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients
Treatment of refractory oral erosive lichen planus with topical Rapamycin: 7 cases
Cryptotanshinone inhibits cancer cell proliferation by suppressing mammalian target of Rapamycin–mediated cyclin D1 expression and Rb phosphorylation
Tubers and tumors: Rapamycin therapy for benign and malignant tumors
The pre-clinical assessment of Rapamycin-eluting, durable polymer-free stent coating concepts
Rapamycin weekly maintenance dosing and the potential efficacy of combination sorafenib plus Rapamycin but not atorvastatin or doxycycline in tuberous …
EGFR signaling through an Akt-SREBP-1–dependent, Rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy
Rapamycin promotes arterial thrombosis in vivo: implications for everolimus and zotarolimus eluting stents
Expansion of the target of Rapamycin (TOR) kinase family and function in Leishmania shows that TOR3 is required for acidocalcisome biogenesis and animal infectivity
Long‐term blood vessel removal with combined laser and topical Rapamycin antiangiogenic therapy: Implications for effective port wine stain treatment
R1507, a fully human monoclonal antibody targeting IGF‐1R, is effective alone and in combination with Rapamycin in inhibiting growth of osteosarcoma xenografts
EphA2 mutation in lung squamous cell carcinoma promotes increased cell survival, cell invasion, focal adhesions, and mammalian target of Rapamycin …
Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model
Mammalian target of Rapamycin signaling in the spinal cord is required for neuronal plasticity and behavioral hypersensitivity associated with neuropathy in …
Rapamycin regulates endothelial cell migration through regulation of the cyclin-dependent kinase inhibitor p27Kip1
Activated mammalian target of Rapamycin is a potential therapeutic target in gastric cancer
Mutual regulation of hypoxia-inducible factor and mammalian target of Rapamycin as a function of oxygen availability
Rapamycin selectively inhibits expression of an inducible keratin (K6a) in human keratinocytes and improves symptoms in pachyonychia congenita patients
Rapamycin inhibits postprandial-mediated X-box-binding protein-1 splicing in rat liver
inhibition of human T-cell proliferation by mammalian target of Rapamycin (mTOR) antagonists requires noncoding RNA growth-arrest-specific transcript 5 (GAS5)
Mammalian target of Rapamycin is activated in association with myometrial proliferation during pregnancy
Expression status and prognostic significance of mammalian target of Rapamycin pathway members in urothelial carcinoma of urinary bladder after cystectomy
A phase 2 study of the oral mammalian target of Rapamycin inhibitor, everolimus, in patients with recurrent endometrial carcinoma
Mammalian target of Rapamycin (mTOR) regulates TLR3 induced cytokines in human oral keratinocytes
Rapamycin-mediated FOXO1 inactivation reduces the anticancer efficacy of Rapamycin
Rapamycin for refractory acute graft-versus-host disease
Life span extension by resveratrol, Rapamycin, and metformin: The promise of dietary restriction mimetics for an healthy aging
Nucleus accumbens core mammalian target of Rapamycin signaling pathway is critical for cue-induced reinstatement of cocaine seeking in rats
New approach for local delivery of Rapamycin by bioadhesive PLGA-carbopol nanoparticles
Activation of the mammalian target of Rapamycin signalling pathway in prostate cancer and its association with patient clinicopathological characteristics
… triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c‐Jun N‐terminal kinase, Akt and mammalian target of Rapamycin …
Rapamycin induces autophagic flux in neurons
Development and characterization of liposomal formulations for Rapamycin delivery and investigation of their antiproliferative effect on MCF7 cells
A pilot trial of the mTOR (mammalian target of Rapamycin) inhibitor RAD001 in patients with advanced B-CLL
Survival benefit with proapoptotic molecular and pathologic responses from dual targeting of mammalian target of Rapamycin and epidermal growth factor …
Pyrazolopyrimidines as highly potent and selective, ATP-competitive inhibitors of the mammalian target of Rapamycin (mTOR): Optimization of the 1-substituent
A randomized optical coherence tomography study of coronary stent strut coverage and luminal protrusion with Rapamycin-eluting stents
The target of Rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathway
Mammalian target of Rapamycin signaling and autophagy: roles in lymphangioleiomyomatosis therapy
Rapamycin (sirolimus) in tuberous sclerosis associated pediatric central nervous system tumors
Targeted therapy of human osteosarcoma with 17AAG or Rapamycin: characterization of induced apoptosis and inhibition of mTOR and Akt/MAPK/Wnt pathways
Conversion to Rapamycin immunosuppression for malignancy after kidney transplantation
cAMP-dependent activation of mammalian target of Rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4
Immunosuppression using the mammalian target of Rapamycin (mTOR) inhibitor everolimus: pilot study shows significant cognitive and affective improvement
Late progression of renal pathology and cyst enlargement is reduced by Rapamycin in a mouse model of nephronophthisis
Targeting melanoma with dual phosphoinositide 3-kinase/mammalian target of Rapamycin inhibitors
Oral Rapamycin reduces tumour burden and vascularization in Lkb1+/− mice
Rapamycin and MPA, but not CsA, impair human NK cell cytotoxicity due to differential effects on NK cell phenotype
NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas
Broadening the therapeutic scope for Rapamycin treatment
Dual phosphoinositide 3-kinase/mammalian target of Rapamycin blockade is an effective radiosensitizing strategy for the treatment of non–small cell lung cancer …
Upregulation of the mammalian target of Rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic β-cells leads to increased β-cell mass and …
mTORC1 inhibition via Rapamycin promotes triacylglycerol lipolysis and release of free fatty acids in 3T3-L1 adipocytes
Mammalian target of Rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis
Effects of metformin on mammalian target of Rapamycin in a mouse model of endometrial hyperplasia
Rapamycin inhibits oncogenic intestinal ion channels and neoplasia in APC Min/+ mice
Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by Rapamycin
Early and late effects of the immunosuppressants Rapamycin and mycophenolate mofetil on UV carcinogenesis
Curcumin inhibits carcinogen and nicotine-induced Mammalian target of Rapamycin pathway activation in head and neck squamous cell carcinoma
Differing effects of systemically administered Rapamycin on consolidation and reconsolidation of context vs. cued fear memories
The antidepressant sertraline inhibits translation initiation by curtailing mammalian target of Rapamycin signaling
Vascular endothelial growth factor-C protects prostate cancer cells from oxidative stress by the activation of mammalian target of Rapamycin complex-2 and AKT-1
Rapamycin-induced Gln3 dephosphorylation is insufficient for nuclear localization: Sit4 and PP2A phosphatases are regulated and function differently
Melatonin attenuates methamphetamine‐induced deactivation of the mammalian target of Rapamycin signaling to induce autophagy in SK‐N‐SH cells
Monotherapy Rapamycin allows an increase of CD4+ CD25bright+ FoxP3+ T cells in renal recipients
Rapamycin: the cure for all that ails
Activation of mammalian target of Rapamycin signaling in spatial learning
Dual inhibition of mitogen-activated protein kinase kinase and mammalian target of Rapamycin in differentiated and anaplastic thyroid cancer
Comparison of radiosensitizing effects of the mammalian target of Rapamycin inhibitor CCI-779 to cisplatin in experimental models of head and neck squamous cell …
The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin signaling network in normal myelopoiesis and leukemogenesis
MYC activity mitigates response to Rapamycin in prostate cancer through eukaryotic initiation factor 4E–binding protein 1–mediated inhibition of autophagy
Successful control of intractable hypoglycemia using Rapamycin in an 86-year-old man with a pancreatic insulin-secreting islet cell tumor and metastases
Generation of high Rapamycin producing strain via rational metabolic pathway‐based mutagenesis and further titer improvement with fed‐batch bioprocess …
Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor NVP-BEZ235 against T-cell acute lymphoblastic leukemia
Rapamycin-Insensitive Up-Regulation of MMP2 and Other Genes in Tuberous Sclerosis Complex 2–Deficient Lymphangioleiomyomatosis-Like Cells
Increasing longevity through caloric restriction or Rapamycin feeding in mammals: common mechanisms for common outcomes?
Rapamycin inhibits anal carcinogenesis in two preclinical animal models
Overexpression of the mammalian target of Rapamycin: a novel biomarker for poor survival in resected early stage non-small cell lung cancer
Mammalian target of Rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein–protein interactions …
Downregulation of Notch pathway by a γ-secretase inhibitor attenuates AKT/mammalian target of Rapamycin signaling and glucose uptake in an ERBB2 transgenic …
A phosphatidylinositol 3-kinase/protein kinase B-independent activation of mammalian target of Rapamycin signaling is sufficient to induce skeletal muscle hypertrophy
… -1, 3, 5-triazine) derivatives: potent adenosine 5′-triphosphate competitive phosphatidylinositol-3-kinase/mammalian target of Rapamycin inhibitors: discovery of …
Rapamycin enhances LPS induction of tissue factor and tumor necrosis factor-α expression in macrophages by reducing IL-10 expression
Rapamycin protects mice from staphylococcal enterotoxin B-induced toxic shock and blocks cytokine release in vitro and in vivo
Pneumonitis associated with mammalian target of Rapamycin inhibitors in renal transplant recipients: a single-center experience
Discovery of potent and selective inhibitors of the mammalian target of Rapamycin (mTOR) kinase
Antimyeloma activity of the orally bioavailable dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor NVP-BEZ235
Rapamycin inhibits IGF-1 stimulated cell motility through PP2A pathway
Mammalian target of Rapamycin is a biomarker of poor survival in metastatic serous ovarian carcinoma
Involvement of heterogeneous ribonucleoprotein F in the regulation of cell proliferation via the mammalian target of Rapamycin/S6 kinase 2 pathway
Treatment with Rapamycin ameliorates clinical and histological signs of protracted relapsing experimental allergic encephalomyelitis in Dark Agouti rats and induces …
Rapamycin and CCI‐779 inhibit the mammalian target of Rapamycin signalling in hepatocellular carcinoma
mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies Rapamycin mechanism of action
Preclinical in vivo evaluation of Rapamycin in human malignant peripheral nerve sheath explant xenograft
Hypersensitivity of Ph-positive lymphoid cell lines to Rapamycin: Possible clinical application of mTOR inhibitor
Mammalian target of Rapamycin complex 1 is involved in differentiation of regenerating myofibers in vivo
Rapamycin as a therapy of choice after renal transplantation in a patient with tuberous sclerosis complex
Treating triple-negative breast cancer by a combination of Rapamycin and cyclophosphamide: an in vivo bioluminescence imaging study
Antitumoral activity of Rapamycin mediated through inhibition of HIF-1alpha and VEGF in hepatocellular carcinoma
Aberrant hyperactivation of akt and Mammalian target of Rapamycin complex 1 signaling in sporadic chordomas
HIV-associated nephropathy: role of mammalian target of Rapamycin pathway
The Rapamycin-regulated gene expression signature determines prognosis for breast cancer
… acid starvation of Saccharomyces cerevisiae and Candida albicans acetolactate synthase (ilv2Δ) mutants is influenced by the carbon source and Rapamycin
Combined Bcl-2/Mammalian Target of Rapamycin inhibition Leads to Enhanced Radiosensitization via Induction of Apoptosis and Autophagy in Non–Small Cell Lung …
Rapamycin down-regulates inducible nitric oxide synthase by inducing proteasomal degradation
Functional interaction of mammalian target of Rapamycin complexes in regulating mammalian cell size and cell cycle
Efficacy, tolerance, and safety of mammalian target of Rapamycin inhibitors as rescue immunosuppressants in liver transplantation
Rapamycin induces the TGFβ1/Smad signaling cascade in renal mesangial cells upstream of mTOR
… 3-kinase (PI3K) and the mammalian target of Rapamycin (mTOR): design, synthesis, and superior antitumor activity of novel wortmannin− Rapamycin conjugates
Developing antiepileptogenic drugs for acquired epilepsy: targeting the mammalian target of Rapamycin (mTOR) pathway
Hepatitis C virus NS5A activates the mammalian target of Rapamycin (mTOR) pathway, contributing to cell survival by disrupting the interaction between …
Naive CD4 t cell proliferation is controlled by mammalian target of Rapamycin regulation of GRAIL expression
Activation of the mammalian target of Rapamycin signalling pathway in epidermal tumours and its correlation with cyclin‐dependent kinase 2
The effects of Rapamycin on lens epithelial cell proliferation, migration, and matrix formation: an in vitro study
Distinct phosphatase requirements and GATA factor responses to nitrogen catabolite repression and Rapamycin treatment in Saccharomyces cerevisiae
Rapamycin induces growth retardation by disrupting angiogenesis in the growth plate
… protects mouse and human hematopoietic progenitors from γ-irradiation through extracellular signal-regulated kinase/mammalian target of Rapamycin …
Rapamycin inhibits cell proliferation in type I and type II endometrial carcinomas: a search for biomarkers of sensitivity to treatment
Dramatic improvement in pulmonary hypertension with Rapamycin
High expression of mammalian target of Rapamycin is associated with better outcome for patients with early stage lung adenocarcinoma
Phase Ib study of weekly mammalian target of Rapamycin inhibitor ridaforolimus (AP23573; MK-8669) with weekly paclitaxel
Expression of EBV latent antigens, mammalian target of Rapamycin, and tumor suppression genes in EBV-positive smooth muscle tumors: clinical and therapeutic …
Identification of functional FKB protein in Echinococcus granulosus: its involvement in the protoscolicidal action of Rapamycin derivates and in calcium homeostasis
The role of phosphoinositide 3‐kinase and phosphatidic acid in the regulation of mammalian target of Rapamycin following eccentric contractions
Placental mammalian target of Rapamycin and related signaling pathways in an ovine model of intrauterine growth restriction
Rapamycin inhibits proliferation and migration of hepatoma cells in vitro
TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers Rapamycin sensitivity
Rapamycin response in tumorigenic and non-tumorigenic hepatic cell lines
Activation of the AKT and mammalian target of Rapamycin pathways and the inhibitory effects of Rapamycin on those pathways in canine malignant melanoma cell lines
Rapamycin as an alternative to surgical treatment of subependymal giant cell astrocytomas in a patient with tuberous sclerosis complex: Case report
Rapamycin-eluting stents in the arterial duct: experimental observations in the pig model.
Device-based local delivery of siRNA against mammalian target of Rapamycin (mTOR) in a murine subcutaneous implant model to inhibit fibrous encapsulation
mTOR inhibitor Rapamycin alone or combined with cisplatin inhibits growth of esophageal squamous cell carcinoma in nude mice
Exploring mammalian target of Rapamycin (mTOR) inhibition for treatment of mantle cell lymphoma and other hematologic malignancies
Target of Rapamycin (TOR)-like 1 kinase is involved in the control of polyphosphate levels and acidocalcisome maintenance in Trypanosoma brucei
Rapid modification of proteins using a Rapamycin-inducible tobacco etch virus protease system
Concurrent and sequential administration of chemotherapy and the Mammalian target of Rapamycin inhibitor temsirolimus in human cancer cells and xenografts
Mammalian target of Rapamycin complex 1 (mTORC1) signaling in energy balance and obesity
Bortezomib can suppress activation of Rapamycin-resistant memory T cells without affecting regulatory T-cell viability in non-human primates
Rapamycin Prevents and Breaks the Anti-CD3–Induced Tolerance in NOD Mice
Rapamycin generates anti-apoptotic human Th1/Tc1 cells via autophagy for induction of xenogeneic GVHD
Polylactide-glycoli acid and Rapamycin coating intraocular lens prevent posterior capsular opacification in rabbit eyes
Regulation of cell death and epileptogenesis by the mammalian target of Rapamycin (mTOR): a double-edged sword?
Rapamycin inhibits growth of cholangiocarcinoma cells.
The Insulin-like Growth Factor-1 Receptor–Targeting Antibody, CP-751,871, Suppresses Tumor-Derived VEGF and Synergizes with Rapamycin in Models of …
Rapamycin induces autophagy in islets: relevance in islet transplantation
Mammalian target of Rapamycin inhibition abrogates insulin-mediated mammary tumor progression in type 2 diabetes
Long-term clinical results following stenting of the left main stem: insights from RESEARCH (Rapamycin-Eluting Stent Evaluated at Rotterdam Cardiology Hospital) …
Rapamycin by itself and additively in combination with carboplatin inhibits the growth of ovarian cancer cells
Evaluation of in vivo antineoplastic effects of Rapamycin in patients with chemotherapy-refractory AML
Expression and mechanism of mammalian target of Rapamycin in age-related renal cell senescence and organ aging
Rapid improvement of nephrogenic systemic fibrosis with Rapamycin therapy: possible role of phospho-70-ribosomal-S6 kinase
Inactivation of mammalian target of Rapamycin increases STAT1 nuclear content and transcriptional activity in α4-and protein phosphatase 2A-dependent …
Testing intravitreal toxicity of Rapamycin in rabbit eyes
Antagonism of the mammalian target of Rapamycin selectively mediates metabolic effects of epidermal growth factor receptor inhibition and protects human malignant …
ATP-mediated protein kinase B Akt/mammalian target of Rapamycin mTOR/p70 ribosomal S6 protein p70S6 kinase signaling pathway activation promotes …
Delayed re-endothelialization with Rapamycin-coated stents is rescued by the addition of a glycogen synthase kinase-3β inhibitor
Regulation of gene expression in hepatic cells by the mammalian Target of Rapamycin (mTOR)
inhibition of mammalian target of Rapamycin signaling potentiates the effects of all‐trans retinoic acid to induce growth arrest and differentiation of human acute …
Rapamycin enhances chemotherapy‐induced cytotoxicity by inhibiting the expressions of TS and ERK in gastric cancer cells
Pilot study: Rapamycin in advanced hepatocellular carcinoma
Mammalian target of Rapamycin as a novel target in the treatment of hepatocellular carcinoma.
Mammalian target of Rapamycin: a new target in prostate cancer
MAPK, phosphatidylinositol 3-kinase, and mammalian target of Rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic …
Rapamycin delays tumor development in murine livers by inhibiting proliferation of hepatocytes with DNA damage
The Rapamycin-derivative RAD001 (everolimus) inhibits cell viability and interacts with the Akt–mTOR–p70S6K pathway in human medullary thyroid carcinoma cells
Rapamycin and the transcription factor C/EBPβ as a switch in osteoclast differentiation: implications for lytic bone diseases
Mammalian target of Rapamycin (mTOR) is involved in the survival of cells mediated by chemokine receptor 7 through PI3K/Akt in metastatic squamous cell carcinoma …
Rapamycin inhibits lung metastasis of B16 melanoma cells through down‐regulating alphav integrin expression and up‐regulating apoptosis signaling
Mammalian target of Rapamycin (mTOR) induces proliferation and de-differentiation responses to three coordinate pathophysiologic stimuli (mechanical strain …
PKI-179: an orally efficacious dual phosphatidylinositol-3-kinase (PI3K)/mammalian target of Rapamycin (mTOR) inhibitor
Effect of Rapamycin on lifespan in Drosophila
Luteinizing hormone stimulates mammalian target of Rapamycin signaling in bovine luteal cells via pathways independent of AKT and mitogen-activated protein kinase …
The effect of Rapamycin on angiogenesis in chick chorioalantoic membrane
Mammalian target of Rapamycin pathway promotes tumor-induced angiogenesis in adenoid cystic carcinoma: its suppression by isoliquiritigenin through dual …
Regulation of gastric hormones by systemic Rapamycin
Effect of combination treatment of Rapamycin and isoflavones on mTOR pathway in human glioblastoma (U87) cells
Distinct subsets of Sit4 holophosphatases are required for inhibition of Saccharomyces cerevisiae growth by Rapamycin and zymocin
Activation of phosphatidylinositol 3-kinase/Akt-mammalian target of Rapamycin signaling pathway in the hippocampus is essential for the acquisition of morphine …
Rapamycin inhibits re-endothelialization after percutaneous coronary intervention by impeding the proliferation and migration of endothelial cells and …
Critical and diverse involvement of Akt/mammalian target of Rapamycin signaling in human lung carcinomas
… yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective Mammalian Target of Rapamycin (mTOR) Inhibitor for …
Phosphoinositide 3-kinase (PI3K) and the nutrient sensing mTOR (mammalian target of Rapamycin) pathways control T cell migration
Glycogen synthase kinase-3 and mammalian target of Rapamycin pathways contribute to DNA synthesis, cell cycle progression, and proliferation in human islets
Periadventitial Rapamycin-eluting microbeads promote vein graft disease in long-term pig vein-into-artery interposition grafts
Inhibitory effect of Rapamycin and dexamethasone on production of IL-17 and IFN-γ in Vogt–Koyanagi–Harada patients
Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of Rapamycin complex 1 to enhance proliferation
Novel mechanism of reducing tumourigenesis: upregulation of the DNA repair enzyme OGG1 by Rapamycin-mediated AMPK activation and mTOR inhibition
Rapamycin‐Conditioned Donor Dendritic Cells Differentiate CD4+CD25+Foxp3+ T Cells In Vitro with TGF‐β1 for Islet Transplantation
Mammalian Target of Rapamycin–Dependent Acinar Cell Neoplasia after Inactivation of Apc and Pten in the Mouse Salivary Gland: Implications for Human Acinic Cell …
The Drosophila FoxA ortholog Fork head regulates growth and gene expression downstream of Target of Rapamycin
Rescue immunosuppression with mammalian target of Rapamycin inhibitor drugs in liver transplantation
In-vitro release of Rapamycin from a thermosensitive polymer for the inhibition of vascular smooth muscle cell proliferation
Influence of combined treatment of low dose Rapamycin and cyclosporin A on corneal allograft survival
Low-dose Rapamycin reduces kidney volume angiomyolipomas and prevents the loss of renal function in a patient with tuberous sclerosis complex
Rapamycin attenuates the severity of murine adriamycin nephropathy
Rapamycin and curcumin induce apoptosis in primary resting B chronic lymphocytic leukemia cells
Stage 2 combination testing of Rapamycin with cytotoxic agents by the Pediatric Preclinical Testing Program
Targeting the mammalian target of Rapamycin to inhibit VEGF and cytokines for the treatment of primary effusion lymphoma
Human Protein Phosphatase PP6 Regulatory Subunits Provide Sit4-Dependent and Rapamycin–Sensitive Sap Function in Saccharomyces cerevisiae
… cell marker upregulation in normal cutaneous vessels following pulsed‐dye laser exposure and its abrogation by concurrent Rapamycin administration: implications for …
Monitoring kidney and renal cyst volumes applying MR approaches on a Rapamycin treated mouse model of ADPKD
Rapamycin promotes the expansion of CD4+ Foxp3+ regulatory T cells after liver transplantation
… cells treated with mammalian target of Rapamycin inhibitors: rationale for combined treatment with extracellular signal–regulated kinase inhibitors and Rapamycin
Effective treatment of advanced colorectal cancer by Rapamycin and 5-FU/oxaliplatin monitored by TIMP-1
Anti-CD154 mAb and Rapamycin induce T regulatory cell mediated tolerance in rat-to-mouse islet transplantation
Rictor phosphorylation on the Thr-1135 site does not require mammalian target of Rapamycin complex 2
Comparison of three Rapamycin dosing schedules in A/J Tsc2+/-mice and improved survival with angiogenesis inhibitor or asparaginase treatment in mice …
Effect of Rapamycin on cue-induced drug craving in abstinent heroin addicts
Adenosine 5′-monophosphate-activated protein kinase-mammalian target of Rapamycin cross talk regulates brown adipocyte differentiation
Intracellular parasitism with Toxoplasma gondii stimulates mammalian‐target‐of‐Rapamycin‐dependent host cell growth despite impaired signalling to S6K1 and 4E …
Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of Rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia
The synergic effects of Rapamycin and extremely low frequency electromagnetic field on angiogenesis
Rapamycin therapy for renal, brain, and skin lesions in a tuberous sclerosis patient
Rapamycin effects on mTOR signaling in benign, premalignant and malignant human breast epithelial cells
Combined inhibition of MEK and mammalian target of Rapamycin abolishes phosphorylation of cyclin-dependent kinase 4 in glioblastoma cell lines and prevents their …
Structural basis for the association of the redox-sensitive target of Rapamycin FATC domain with membrane-mimetic micelles
NV‐128, a novel isoflavone derivative, induces caspase‐independent cell death through the Akt/mammalian target of Rapamycin pathway
Activating transcription factor 4 and CCAAT/enhancer-binding protein-β negatively regulate the mammalian target of Rapamycin via Redd1 expression in response to …
Epidermal growth factor receptor and mammalian target of Rapamycin as therapeutic targets in malignant glioma: current clinical status and perspectives
Chemopreventive efficacy of Rapamycin on Peutz–Jeghers syndrome in a mouse model
… Stents Results in Better Clinical Outcomes During 6-Year Follow-Up Than Bare-Metal Stents: An Analysis of the RESEARCH (Rapamycin-Eluting Stent Evaluated At …
… repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AKT-mammalian target of Rapamycin …
… of the epidermal growth factor receptor/mammalian target of Rapamycin pathway by epidermal growth factor receptor inhibitors and Rapamycin results in reduced cell …
inhibition of the mammalian target of Rapamycin promotes cyclic AMP-induced differentiation of NG108-15 cells
Human CD34-derived myeloid dendritic cell development requires intact phosphatidylinositol 3-kinase–protein kinase B–mammalian target of Rapamycin signaling
The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin signaling network in cancer stem cell biology
… -6-aryl-1H-pyrazolo[3,4-d]pyrimidines as Highly Potent and Selective ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin (mTOR): Optimization of the …
PI3K signaling regulates Rapamycin-insensitive translation initiation complex formation in vaccinia virus-infected cells
Silymarin inhibits endothelial progenitor cells’ senescence and protects against the antiproliferative activity of Rapamycin: preliminary study
inhibition of voltage-gated K+ channels in dendritic cells by Rapamycin
Phase I study of the oral mammalian target of Rapamycin inhibitor everolimus (RAD001) in Japanese patients with relapsed or refractory non-Hodgkin lymphoma
Regulation by FK506 and Rapamycin of Ca2+ release from the sarcoplasmic reticulum in vascular smooth muscle: the role of FK506 binding proteins and mTOR
… using bare-metal and drug-eluting stents in previously untreated coronary artery disease: insights from the RESEARCH (Rapamycin-Eluting Stent Evaluated at …
Rrd1 isomerizes RNA polymerase II in response to Rapamycin
Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mammalian target of Rapamycin activity and p27Kip1 …
Rapamycin impairs metabolism-secretion coupling in rat pancreatic islets by suppressing carbohydrate metabolism
If mammalian target of metformin indirectly is mammalian target of Rapamycin, then the insulin-like growth factor-1 receptor axis will audit the efficacy of metformin in …
The transcription factor SP1 regulates centriole function and chromosomal stability through a functional interaction with the mammalian target of Rapamycin/raptor …
Involvement of autophagy via mammalian target of Rapamycin (mTOR) inhibition in tributyltin-induced neuronal cell death
Rapamycin protects heart from ischemia/reperfusion injury independent of autophagy by activating PI3 kinase-Akt pathway and mitochondria KATP channel
… peroxisome proliferator-activated receptor (PPAR) γ protein translation by suppressing the mammalian target of Rapamycin (mTOR) signaling pathway in …
SP600125 negatively regulates the mammalian target of Rapamycin via ATF4-induced Redd1 expression
… in the phosphoinositide 3-kinase/Akt signaling pathway confer sensitivity of thyroid cancer cells to therapeutic targeting of Akt and mammalian target of Rapamycin
Rapamycin Inhibits VEGF‐Induced Microvascular Hyperpermeability In Vivo
Iron deficiency down-regulates the Akt/TSC1-TSC2/mammalian Target of Rapamycin signaling pathway in rats and in COS-1 cells
Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of Rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a …
Bim is the key mediator of glucocorticoid-induced apoptosis and of its potentiation by Rapamycin in human myeloma cells
Rapamycin for focal segmental glomerulosclerosis: a report of 3 cases
inhibition of mammalian target of Rapamycin (mTOR) signalling in C2C12 myoblasts prevents myogenic differentiation without affecting the hyperphosphorylation of 4E …
Regression of left ventricular hypertrophy in kidney transplant recipients: the potential role for inhibition of mammalian target of Rapamycin
… by leucine supplementation in malnourished rats: possible involvement of the phosphatidylinositol 3-phosphate kinase/mammalian target protein of Rapamycin …
Rapamycin inhibits cholangiocyte regeneration by blocking interleukin‐6–induced activation of signal transducer and activator of transcription 3 after liver …
A role for mammalian target of Rapamycin–mTOR-pathway in non alcoholic steatohepatitis related-cirrhosis
Targeting mammalian target of Rapamycin to both downregulate and disable the P-glycoprotein pump in multidrug-resistant B-cell lymphoma cell lines
Severe rhabdomyolysis and acute renal failure secondary to concomitant use of simvastatin with Rapamycin plus tacrolimus in liver transplant patient
Rapamycin promotes the enrichment of CD4+ CD25hiFoxP3+ T regulatory cells from naive CD4+ T cells of baboon that suppress antiporcine xenogenic response in …
Rapamycin, but not cyclosporine A, inhibits vascularization and incorporation of implanted surgical meshes
Rapamycin‐treated mature dendritic cells have a unique cytokine secretion profile and impaired allostimulatory capacity
Rapamycin induces autophagy and exacerbates metabolism associated complications in a mouse model of type 1 diabetes
Effective inhibition of xenografts of hepatocellular carcinoma (HepG2) by Rapamycin and bevacizumab in an intrahepatic model
Inducible somatic oocyte destruction in response to Rapamycin requires wild-type regulation of follicle cell epithelial polarity
Cutaneous T‐cell lymphoma cells are sensitive to Rapamycin
… ligand mediates follicular lymphoma B-cell proliferation and cyclin D1 expression through phosphatidylinositol 3-kinase–regulated mammalian target of Rapamycin …
Mammalian target of Rapamycin (mTOR) and S6 kinase down-regulate phospholipase D2 basal expression and function
Rapamycin enhances the susceptibility of both androgen-dependent and-independent prostate carcinoma cells to docetaxel
The phosphatidylinositol 3-kinase-AKT-mammalian target of Rapamycin signaling network and the control of normal myelopoiesis
CD4+ Foxp3+ regulatory T cells converted by Rapamycin from peripheral CD4+ CD25˜. naive T cells display more potent regulatory abilityin vitro
Chemistry and pharmacology of Rapamycin and its derivatives
Combining the receptor tyrosine kinase inhibitor AEE788 and the mammalian target of Rapamycin (mTOR) inhibitor RAD001 strongly inhibits adhesion and …
Mammalian target of the Rapamycin pathway is involved in non-alcoholic fatty liver disease
Antiproliferative effects of Rapamycin and celecoxib in angiosarcoma cell lines
Phase 1 and pharmacokinetic study of everolimus, a mammalian target of Rapamycin inhibitor, in combination with docetaxel for recurrent/refractory nonsmall cell lung …
mTOR inhibitor Rapamycin suppresses striatal post-ischemic LTP
Ribosomal protein S6 kinase is a critical downstream effector of the target of Rapamycin complex 1 for long-term facilitation in Aplysia
FK506 and Rapamycin neuroprotect erection and involve different immunophilins in a rat model of cavernous nerve injury
Rapamycin increases the p53/MDM2 protein ratio and p53-dependent apoptosis by translational inhibition of mdm2 in cancer cells
MCF-7 breast cancer cells selected for tamoxifen resistance acquire new phenotypes differing in DNA content, phospho-HER2 and PAX2 expression, and Rapamycin …
Lysosomal accumulation of mTOR is enhanced by Rapamycin
Systemic Rapamycin without loading dose for restenosis prevention after coronary bare metal stent implantation
Beclin 1 self‐association is independent of autophagy induction by amino acid deprivation and Rapamycin treatment
High expression levels of the mammalian target of Rapamycin inhibitor DEPTOR are predictive of response to thalidomide in myeloma
… of the effects of NF-κB or PI3K pathway inhibitors on the LPS-induced gene expression profile in RAW264. 7 cells: synergistic effects of Rapamycin on LPS-induced …
Combined administration of a mutant TGF-β1/Fc and Rapamycin promotes induction of regulatory T cells and islet allograft tolerance
Evidence for cell cycle-dependent, Rapamycin-resistant phosphorylation of ribosomal protein S6 at S240/244
Rapamycin reduces high-amplitude, mechanical stretch-induced apoptosis in pulmonary microvascular endothelial cells
Effect of low-dose Rapamycin on tumor growth in two human hepatocellular cancer cell lines
The serine 2481-autophosphorylated form of mammalian Target Of Rapamycin (mTOR) is localized to midzone and midbody in dividing cancer cells
Rapamycin: could it enhance vaccine efficacy?
Rapamycin and tacrolimus differentially modulate acute graft‐versus‐host disease in rats after liver transplantation
Infarct size is increased in female post-MI rats treated with Rapamycin
Protein kinase C-δ and phosphatidylinositol 3-kinase/Akt activate mammalian target of Rapamycin to modulate NF-κB activation and intercellular adhesion …
Glutamate-dependent phosphorylation of the mammalian target of Rapamycin (mTOR) in Bergmann glial cells
Rapid regression of lymphadenopathy upon Rapamycin treatment in a child with autoimmune lymphoproliferative syndrome
Lead optimization of N-3-substituted 7-morpholinotriazolopyrimidines as dual phosphoinositide 3-kinase/mammalian target of Rapamycin inhibitors: discovery of PKI …
mTOR, the mammalian target of Rapamycin
Oral Rapamycin attenuates atherosclerosis without affecting the arterial responsiveness of resistance vessels in apolipoprotein E-deficient mice
Glucagon acts in a dominant manner to repress insulin-induced mammalian target of Rapamycin complex 1 signaling in perfused rat liver
Targeting heat‐shock protein 90 improves efficacy of Rapamycin in a model of hepatocellular carcinoma in mice
Rapamycin, the mTOR kinase inhibitor, sensitizes acute myeloid leukemia cells, HL-60 cells, to the cytotoxic effect of arabinozide cytarabine
inhibition of human immunodeficiency virus (HIV‐1) infection in human peripheral blood leucocytes‐SCID reconstituted mice by Rapamycin
Mammalian target of Rapamycin activity is required for expansion of CD34+ hematopoietic progenitor cells
Effects of Rapamycin on prostate cancer PC-3 cells
Five‐year clinical outcomes after coronary stenting of chronic total occlusion using sirolimus‐eluting stents: Insights from the Rapamycin‐eluting stent evaluated at …
… of essential amino acid deficiency in the anterior piriform cortex, that requires the uncharged tRNA/GCN2 pathway, is sensitive to wortmannin but not Rapamycin
Failed rescue therapy with Rapamycin after paraquat intoxication
mTOR pathway inhibitors in cancer therapy: moving past Rapamycin
A spectrophotometric assay for routine measurement of mammalian target of Rapamycin activity in cell lysates
Rhabdomyolysis and acute kidney injury secondary to concomitant use of fluvastatin and Rapamycin in a renal transplant recipient
Rapamycin in combination with donor-specific CD4+ CD25+ Treg cells amplified in vitro might be realize the immune tolerance in clinical organ transplantation
Shiga toxin 1-induced proinflammatory cytokine production is regulated by the phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin signaling pathway
Triazines incorporating (R)-3-methylmorpholine are potent inhibitors of the mammalian target of Rapamycin (mTOR) with selectivity over PI3Kα
Timing of conversion to mammalian target of Rapamycin inhibitors is crucial in liver transplant recipients with impaired renal function at transplantation
Novel benzofuran-3-one indole inhibitors of PI3 kinase-α and the mammalian target of Rapamycin: Hit to lead studies
Fission yeast TOR and Rapamycin
Activated mammalian target of Rapamycin is associated with T regulatory cell insufficiency in nasal polyps
Rapamycin or tacrolimus alone fails to resist cardiac allograft accelerated rejection mediated by alloreactive CD4+ memory T cells in mice
A functional link between polo-like kinase 1 and the mammalian target-of-Rapamycin pathway?
The combination of multiple receptor tyrosine kinase inhibitor and mammalian target of Rapamycin inhibitor overcomes erlotinib resistance in lung cancer cell lines …
Experience with everolimus (RAD001), an oral mammalian target of Rapamycin inhibitor, in patients with systemic mastocytosis
Antitumor efficacy profile of PKI-402, a dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor
Rapamycin impairs trabecular bone acquisition from high‐dose but not low‐dose intermittent parathyroid hormone treatment
Steady-state kinetic and inhibition studies of the mammalian target of Rapamycin (mTOR) kinase domain and mTOR complexes
Rapamycin inhibits hepatectomy-induced stimulation of metastatic tumor growth by reduction of angiogenesis, microvascular blood perfusion, and tumor cell …
Impact of mammalian target of Rapamycin inhibition on autosomal-dominant polycystic kidney disease
Limited utility of Rapamycin in severe, refractory Wegener’s granulomatosis
Rescuing 3T3-L1 adipocytes from insulin resistance induced by stimulation of Akt-mammalian target of Rapamycin/p70 S6 kinase (S6K1) pathway and serine …
MYC activity mitigates response to Rapamycin in prostate cancer through 4EBP1-mediated inhibition of autophagy
Target of Rapamycin in the oriental fruit fly Bactrocera dorsalis (hendel): its cloning and effect on yolk protein expression
Rapamycin enhances aplaviroc anti-HIV activity: implications for the clinical development of novel CCR5 antagonists
Reducing the risk of left ventricular hypertrophy in kidney transplant recipients: the potential role of mammalian target of Rapamycin
Molecular pathways involved in hair follicle tumor formation: all about mammalian target of Rapamycin?
Posttransplantation Therapeutic Rapamycin Concentration Protects Nitric Oxide–Related Vascular Endothelial Function: Comparative Effects in Rat Thoracic Aorta …
Controversies in breast cancer: the mammalian target of Rapamycin as a target for breast cancer therapy
WJD008, a dual phosphatidylinositol 3-kinase (PI3K)/mammalian target of Rapamycin inhibitor, prevents PI3K signaling and inhibits the proliferation of transformed …
AZD6244 (ARRY‐142886) enhances the antitumor activity of Rapamycin in mouse models of human hepatocellular carcinoma
Increased frequency of regulatory T cells and selection of highly potent CD62L+ cells during treatment of human lung transplant recipients with Rapamycin
Comparison of Rapamycin-and paclitaxel-eluting stents in patients undergoing primary percutaneous coronary intervention for ST-elevation myocardial infarction
Regulation of protein kinase Cδ downregulation by protein kinase Cε and mammalian target of Rapamycin complex 2
Rapamycin reduces proteinuria and renal damage in the rat remnant kidney model
How does the mammalian target of Rapamycin (mTOR) influence CD8 T-cell differentiation?
Alteration of REDD1-mediated mammalian target of Rapamycin pathway and hypoxia-inducible factor-1α regulation in human breast cancer
Immunohistochemical analysis of the mammalian target of Rapamycin signalling pathway in extramammary Paget’s disease
Preventing restenosis after implantation of bare stents with oral Rapamycin: a randomized angiographic and intravascular ultrasound study with a 5-year clinical follow …
Rapamycin can Inhibit the Development of Chlamydia pneumoniae, which Might Partly Contribute to the Prevention of In-stent Restenosis
Depletion of mammalian target of Rapamycin (mTOR) via siRNA mediated knockdown leads to stabilization of β-catenin and elicits distinct features of …
Indirect antitumor effects of mammalian target of Rapamycin inhibitors against Kaposi sarcoma in transplant patients
… -pyrrolo [2, 3-b] pyridin-3-yl) methylene-4-hydroxybenzofuran-3 (2H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of Rapamycin …
Inhibitors of the mammalian target of Rapamycin and transplant tolerance
Clinical implications of proteinuria in renal transplant recipients switching to Rapamycin for chronic allograft dysfunction
Transforming growth factor beta 1 (TGF-β1) and Rapamycin synergize to effectively suppress human T cell responses via upregulation of FoxP3+ Tregs
Descending serotonergic facilitation mediated by spinal 5-HT3 receptors engages spinal Rapamycin-sensitive pathways in the rat
… replacement in 6-aryl-1H-pyrazolo [3, 4-d] pyrimidines and 2-arylthieno [3, 2-d] pyrimidines: ATP-competitive inhibitors of the mammalian target of Rapamycin (mTOR)
Mycophenolate mofetil versus Rapamycin in Han: SPRD rats with polycystic kidney disease
Rapamycin sensitizes Akt inhibition in malignant human breast epithelial cells
Protection from Rapamycin-induced apoptosis by insulin-like growth factor-I is partially dependent on protein kinase C signaling
Suppression of mTOR complex 2‐dependent AKT phosphorylation in melanoma cells by combined treatment with Rapamycin and LY294002
Antitumour activity of a potent MEK inhibitor RDEA119/BAY 869766 combined with Rapamycin in human orthotopic primary pancreatic cancer xenografts
Effects of delayed Rapamycin treatment on renal fibrosis and inflammation in experimental ischemia reperfusion injury
Cutting edge: Expression of the transcription factor E74-like factor 4 is regulated by the mammalian target of Rapamycin pathway in CD8+ T cells
Loss of inhibitory insulin receptor substrate-1 phosphorylation is an early event in mammalian target of Rapamycin–dependent endometrial hyperplasia and carcinoma
Rapamycin inhibits yeast nucleotide excision repair independently of Tor kinases
ID2‐VEGF‐related Pathways in the Pathogenesis of Kaposi’s Sarcoma: A Link Disrupted by Rapamycin
Phosphorylation of translation factors in response to anoxia in turtles, Trachemys scripta elegans: role of the AMP-activated protein kinase and target of Rapamycin …
Novel mechanism of Rapamycin in GVHD: increase in interstitial regulatory T cells
Low-dose calcineurin inhibitor regimen combined with mammalian target of Rapamycin inhibitors preserves kidney functions in renal transplant recipients without …
Rapamycin for chemoprevention of upper aerodigestive tract cancers
Mutation of a phosphorylatable residue in Put3p affects the magnitude of Rapamycin-induced PUT1 activation in a Gat1p-dependent manner
Spreading of mesothelioma cells is Rapamycin‐sensitive and requires continuing translation
Rapamycin enhances platelet aggregation induced by adenosine diphosphate in vitro
Insulin resistance without elevated mammalian target of Rapamycin complex 1 activity in muscles of mice fed a high-fat diet
4-Substituted-7-azaindoles bearing a ureidobenzofuranone moiety as potent and selective, ATP-competitive inhibitors of the mammalian target of Rapamycin (mTOR)
Serine 2481-autophosphorylation of mammalian target of Rapamycin (mTOR) couples with chromosome condensation and segregation during mitosis: Confocal …
Mammalian target of Rapamycin inhibition prevents glomerular hypertrophy in a model of renal mass reduction
Select nutrients in the ovine uterine lumen. VI. Expression of FK506-binding protein 12-Rapamycin complex-associated protein 1 (FRAP1) and regulators and effectors …
The effect of Rapamycin liposome gutta inhibiting rat corneal neovascularization
Retracted: CCR5 blockade in combination with Rapamycin prolongs cardiac allograft survival in mice
Rapamycin joins the aging fray: maybe Ponce de Leon visited Rapa Nui, not Florida
Adenovirus-mediated eukaryotic initiation factor 4E binding protein-1 in combination with Rapamycin inhibits tumor growth of pancreatic ductal adenocarcinoma in vivo
Effective targeting of STAT5-mediated survival in myeloproliferative neoplasms using ABT-737 combined with Rapamycin
Rapamycin does not adversely affect intrahepatic islet engraftment in mice and improves early islet engraftment in humans
Late conversion to mammalian target of Rapamycin inhibitor/proliferation signal inhibitors in kidney transplant patients: clinical experience in the last 5 years
… between a prospective randomised multicentre cutting balloon angioplasty and bare metal stent trial (REDUCE III) and the Rapamycin-Eluting Stent Evaluation At …
… growth inhibition is augmented by synchronous inhibition of the insulin-like growth factor-1 receptor by NVP-AEW541 and inhibition of mammalian target of Rapamycin …
Rapamycin suppresses the expansion and differentiation of porcine neonatal pancreas cell clusters
The possible cellular mechanism for extending lifespan of mice with Rapamycin
Rapamycin reduces kidney volume and delays the loss of renal function in a patient with autosomal-dominant polycystic kidney disease
… posttranscriptional regulation of insulin-like growth factor-I receptor level via glycogen synthase kinase-3β and mammalian target of Rapamycin in adrenal chromaffin …
Preparation of electrospun poly (L-lactide-co-caprolactone-co-glycolide)/phospholipid polymer/Rapamycin blended fibers for vascular application
Combined effect of Rapamycin and cisplatin on survival of Hep-2 cells in vitro
Adenosine-triphosphate promoting repair of spinal cord injury by activating mammalian target of Rapamycin/signal transducers and activators of transcription 3 signal …
Mammalian target of Rapamycin complex 1 signaling opposes the effects of anchorage loss, leading to activation of Cdk4 and Cdc6 stabilization
Rapamycin for Kaposi’s sarcoma and graft-versus-host disease in bone marrow transplant recipient
Rapamycin instead of mycophenolate mofetil or azathioprine in treatment of post-renal transplantation urothelial carcinoma
First-in-man use of polymer-free valsartan-eluting stents in small coronary vessels: a comparison to polymer-free Rapamycin (2%)-eluting stents
Mammalian target of Rapamycin and autosomal dominant polycystic kidney disease
Rapamycin-induced proteinuria following allogeneic hematopoietic stem cell transplantation
Effect of Rapamycin on leukemia cell lines
inhibition of IGF-I receptor signaling in combination with Rapamycin or temsirolimus increases MYC-N phosphorylation
Role of GLUT1 in the Mammalian Target of Rapamycin Pathway: Mechanisms of Regulation.
Exendin-4 protects pancreatic beta cells from the cytotoxic effect of Rapamycin by inhibiting JNK and p38 phosphorylation
inhibition of mammalian target of Rapamycin (mTOR) in advanced pancreatic cancer: The results of two prospective phase II studies
Monitoring Molecular-Specific Pharmacodynamics of Rapamycin In vivo with Inducible Gal4→ Fluc Transgenic Reporter Mice
Combination of tipifarnib and Rapamycin synergistically inhibits the growth of leukemia cells and overcomes resistance to tipifarnib via alteration of cellular signaling …
Pretreatment with intraluminal Rapamycin nanoparticle perfusion inhibits neointimal hyperplasia in a rabbit vein graft model
Rapamycin prevents Concanavalin A‐induced liver injury by inhibiting lymphocyte activation
Treatment algorithms in metastatic renal cell carcinoma, including the potential role of the novel oral mammalian target of Rapamycin inhibitor Everolimus
Cyclooxygenase 2 mediates the antiangiogenic effect of Rapamycin in Ewing sarcoma
Rapamycin selectively reduces the association of transcripts containing complex 5′ UTRs with ribosomes in C4‐2B prostate cancer cells
Regioselective lipase-catalyzed acylation of 41-desmethoxy-Rapamycin without vinyl esters
Rapamycin inhibits poly (ADP-ribosyl) ation in intact cells
Early loss of mammalian target of Rapamycin complex 1 (mTORC1) signalling and reduction in cell size during dominant-negative suppression of hepatic …
Combination Regimens of nab-Rapamycin (ABI-009) Effective Against MDA-MB-231 Breast-Tumor Xenografts.
Rapamycin Inhibits Activator Protein-1 But Not Nuclear Factor-κB Activity of Mature Bone Marrow-Derived Dendritic Cells
Autosomal dominant polycystic kidney disease (ADPKD): Rapamycin as a new treatment option
Synthesis of the northern sector (C8–C19) of Rapamycin via Chan rearrangement and oxidation of an α-acyloxyacetate
Rapamycin and thalidomide treatment of a patient with refractory metastatic gastroesophageal adenocarcinoma: a case report
Effects of Rapamycin on Breast Cancer Cell Migration through the Cross-Talk of MAPK Pathway.
inhibition of mammalian target of Rapamycin: the janus face of immunosuppression?
Effect of Rapamycin on proliferated human umbilical vein endothelial cell
… 5‐(2‐chloroethyl)‐2‐acetoxy‐benzyl]‐4‐(2‐chloroethyl)‐phenyl acetate inhibits phosphoinositide 3‐kinase/Akt/mammalian target of Rapamycin signalling through JNK …
Progression of graft fibrosis under mammalian target of Rapamycin inhibitor‐based regimen
Effects of Rapamycin on the differentiation and function of macrophages in vitro
Monotherapy Rapamycin in renal transplant recipients with lymphoma successfully treated with rituximab
Rapamycin enhances lipopolysaccharide-induced apoptosis and lung injury
Rapamycin treatment suppresses epileptogenic activity in conditional Pten knockout mice
Influence of Rapamycin on autophagy and apoptosis of two lepidoptera cell lines.
Effect of Rapamycin on proliferation of acute myeloid leukemia cell lines HL-60 and HL-60/VCR
A phase II trial of a mammalian target of Rapamycin inhibitor, temsirolimus, in patients with metastatic breast cancer.
Molecular pathways in metastatic renal cell carcinoma: the evolving role of mammalian target of Rapamycin inhibitors
Anti-insulin-like growth factor-1 receptor (IGF-IR) monoclonal antibody cixutumumab plus mammalian target of Rapamycin (mTOR) inhibitor temsirolimus in metastatic …
Effect of Rapamycin and Cyclosporin A on the expression of TLR5 and Foxp3 in allorejection
Combination therapy of 5-fluorouracil with Rapamycin for hormone receptor-negative human breast cancer
… of D-cyclin translation inhibition in myeloma cells treated with mTOR inhibitors: rationale for combined treatment with ERK inhibitors and Rapamycin
Dual inhibition of Akt/mTOR pathway by nab-Rapamycin and perifosine induces anti-tumor activity in multiple myeloma
Forever young, slim and fit: Rapamycin to the rescue
Evaluation of a Rapamycin‐regulated serotype 2 adeno‐associated viral vector in macaque parotid glands
Recent developments of Rapamycin analogues
Combination of Rapamycin and IL-2 do not affect antigen presentation ability of rat B cell and could promote Tregs proliferation and inhibitory activity
Mammalian target of Rapamycin: MasTOR mediator of cellular changes in pathological states?
Use of a cocktail regimen consisting of soluble galectin-1, Rapamycin and histone deacetylase inhibitor may effectively prevent type 1 diabetes
Identification of Akt-selective cytotoxic compounds that enhance cytotoxic responses to Rapamycin
Mammalian target of Rapamycin, Akt, and phosphatidylinositol 3-kinase signaling
Prevention of hepatic tumor growth and metastasis in rats with Rapamycin
Effect of Rapamycin on apoptosis in human myelodysplastic syndrome cell line MUTZ-1 and its possible mechanisms
A phase I dose-finding and pharmacodynamic study of Rapamycin in combination with bevacizumab in patients with unresectable hepatocellular carcinoma.
Antitumor activity, and antiangiogenic activity of nanoparticle albumin-bound nab-Rapamycin in combination with nab-paclitaxel.
Mammalian target of Rapamycin (mTOR)-induced pneumonitis: Single-institution experience and treatment.
inhibition of cell growth by Rapamycin through targeting mammalian target of Rapamycin signaling pathway in nasopharyngeal carcinoma
Study advance of Rapamycin in the field of transplantation immunology [J]
Release test of Rapamycin in drug-eluting stents
The mechanism and influence of Rapamycin on proliferation of NIH3T3 fibroblasts transfected with mTOR gene [J]
Effects of Rapamycin on angiogenesis and tumor progression in human hepatocellular carcinoma implantation mice
Correlation factors of vascular restenosis and safety following Rapamycin drug-eluting stent implantation
Mammalian target of Rapamycin, its mode of action and clinical response in metastatic clear cell carcinoma
Regulation of bone formation using Rapamycin-induced BMP2 expression system: influence of implanted cell number
Active-site inhibitors of mTOR target Rapamycin-resistant outputs of mTORC1 and mTORC2, PLoS Biol
Effect of Rapamycin on proliferation, apoptosis and regulation of chemokine receptor CXCR4 in RPMI8226 cells
Abstract C62: Identification of GSK2126458, a highly potent inhibitor of phosphoinositide 3‐kinase (PI3K) and the mammalian target of Rapamycin (mTOR)
Rapamycin and HIV Replication in Liver Transplant Recipients
Effects of Rapamycin-loaded poly (lactic-co-glycolic) acid nanoparticles on distribution of cell cycle, expression of p27 protein, and proliferation of human umbilical …
Rapamycin induces apoptosis of lung adenocarcinoma cell A549 under hypoxia and its molecular mechanism
A phase I study of sirolimus (Rapamycin) and bevacizumab in patients with advanced malignancies.
Effects of Rapamycin on collagen type Ⅰ expression in rat myocardial cell induced by CVB 3
Abstract C65: Enhanced antitumor effect by the combination of a PI3K inhibitor ZSTK474 with an mTOR inhibitor Rapamycin
A stimulating new role for Rapamycin
Synergistic augmentation of cisplatin-induced apoptosis in HeLa cells by Rapamycin
Evaluation for synergistic suppression of breast cancer proliferation by Chloroquine in combination with the Rapamycin derivative, Rad001
Rapamycin enhances lifespan: At last, an advantage for transplant recipients?
Rapamycin reverses glucocorticoid resistance in human T-cell acute lymphoblastic leukemia CEM-C1 cells [J]
Effects of Rapamycin on nephropathy of diabetic rats and expressions of vascular endothelial growth factor and its receptor [J]
Interference of mTOR expression enhances sensitivity of esophageal squamous cell carcinoma EC9706 cells to Rapamycin
Can phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibition ERase them all?
Tuberous Sclerosis Complex and the Mammalian Target of Rapamycin Pathways
Comparison of the MEIA and HPLC assays for the measurement of Rapamycin concentration in blood of recipients after renal transplantation [J]
Effects of simvastatin on Rapamycin-treated cardiac microvascular endothelial cells
Combined Rapamycin eye drop in nanometer vector and poly (lactic acid) wafers of cyclosporine A effectively prevents high-risk corneal allograft rejection in rabbits
Mammalian target of Rapamycin inhibitors in the treatment of malignancy after organ transplantation
Target of Rapamycin modulators of and use thereof
Essential Role of Mammalian Target of Rapamycin (mTOR) in LH-dependent Testosterone Production in Rat Leydig Cells.
Rapamycin inhibits growth and metastasis of gallbladder cancer GBC-SD cells.
Pharmacological studies of a novel inhibitor of the mammalian target of Rapamycin (mTOR) signaling pathway
Effects of Rapamycin on mTOR/p70S6K signaling pathway and tumor growth in xenografted esophageal squamous cell carcinoma.
Effect of Rapamycin (serolimus) on in vitro cultured human keratinocytes
Mesenchymal stem cells combined with Rapamycin immuno-regulates the spleniclymphocytes in allogenic mice.
Effect of Rapamycin on the interaction between Salmonella typhi plasmid pR_ (ST98) and macrophages [J]
Expression of JAK/STAT signal transduction pathway and the effects of Rapamycin in lupus nephritis-prone MRL/lpr mice
CIRCULATING CD4CD25 HIGH CD127 LOW REGULATORY T-CELLS AFTER INTRACORONARY IMPLANTATION OF Rapamycin-ELUTING STENTS: PP. 2.73
Preparation and production efficiency of Rapamycin ointment
The influence of coronary stenting with Rapamycin-eluting stents on the number of circulating CD4+ CD25high+ regulatory T-cells
Effect of Rapamycin on Phenotype of Vascular Smooth Muscle Cell and Arterial Intimal Hyperplasia in Rat Cardiac Allograft
Mammalian target of Rapamycin inhibitors in clinical practice: Case reports of everolimus in renal cell carcinoma
Application of stereocontrolled aldol coupling to synthesis of segments of immunosuppressants FK-506 and Rapamycin
Abstract C63: Biological characterization of GSK2126458, a novel and potent inhibitor of phosphoinositide 3‐kinase and the mammalian target of Rapamycin (mTOR)
Current perspectives in metastatic renal cell carcinoma treatment: the role of mammalian target of Rapamycin (mTOR) inhibition
Rapamycin decreases proinflammatory and profibrogenic gene expression in experimental NASH
Expression of mammalian target of Rapamycin and eIF4E signal pathway in cerebral glioma and its clinical significance [J]
Conditional protein stabilization via the small molecules Shld-1 and Rapamycin increases the signal-to-noise ratio with tet-inducible gene expression
A case of Kaposi’s sarcoma in the Rapamycin era
OSI-027, a potent and selective small molecule mTORC1/mTORC2 kinase Inhibitor is mechanistically distinct from Rapamycin
eIF4E Expression Predicts Apoptosis in Response to Epidermal Growth Factor Receptor inhibition and Mammalian Target of Rapamycin inhibition in Triple Negative …
Rapamycin and PD98059 collaborative inhibit mammalian target of Rapamycin pathway in the prevention and treatment of mouse colorectal cancer
Effect of Rapamycin on the growth of hepatocellular carcinoma in nude mice
Rapamycin-based GvHD prophylaxis after T-cell replete unmanipulated haploidentical peripheral stem cell transplantation for advanced leukaemias: preliminary …
Effect of Rapamycin administration in humans on the skeletal muscle protein anabolic response to essential amino acid ingestion
Differential Regulation of TLR4-Mediated TNF-a Release by Mammalian Target of Rapamycin and Glycogen Synthase Kinase-3 in Alveolar Macrophages from …
A newly developed Rapamycin-eluting stent with a biodegradable polymer reduces neointimal formation while allowing greater endothelialization
CONVERSION TO LOW DOSE TACROLIMUS OR Rapamycin 3 MONTHS AFTER KIDNEY TRANSPLANT: A PROSPECTIVE, PROTOCOL BIOPSY GUIDED STUDY …
The Effect of Rapamycin on Cardiac Allograft Vasculopathy in Rats
Abstract A94: effects of different modes of calorie restriction on mammalian target of Rapamycin (mTOR) and IGF-I signaling pathways in mammary fat pads and tumors
Rapamycin-Based GvHD Prophylaxis Is Effective in T-Cell Replete Unmanipulated Haploidentical Peripheral Stem Cell Transplantation for Advanced Haematological …
Role of Rapamycin in renal ischemia-reperfusion injury
Symbol Domestic Rapamycin-eluted stent for treatment of acute myocardial infarction in 108 cases
Rapamycin Used in Kidney Transplantation Patients in China: A Meta-analysis of Clinical Curative Effects
Conversion to Rapamycin in liver transpant recipients with renal insufficiency
Genomewide Profiling of Rapamycin Sensitivity in Saccharomyces cerevisiae on Synthetic Medium
Effect of Rapamycin (serolimus) on in vitro cultured human oral mucosa keratinocytes
Effects of Rapamycin and paclitaxel on different human prostate cancer cells and xenografts
The Generation of Novel Fluorinated Rapamycin Analogues
Treg and Rapamycin effects on humoral immunity in young and old mice (84.12)
EXPERIENCE WITH Rapamycin IN PEDIATRIC LIVER TRANSPLANTATION: 1434
Inhibitory effect of Rapamycin on proliferation of H_ (22) hepatic cancer in mice
Effect of Rapamycin on Postoperative Fibrosis After Filtration Surgery in a Rabbit Model
The mammalian target of Rapamycin in translation and folding
Effect of Rapamycin on the proliferation and apoptosis of glomerular mesangial cells
Transcriptional Profile Changes Induced by Rapamycin in Breast Cancer Maintained in Organ Culture.
Ex Vivo Manufacture of Rapamycin-Resistant Human Th1/Tc1 Cells.
Effect of Rapamycin on regulator T cells induced by TGF-β1 in vitro
Study of long-term safety and efficacy of domestic Firebird Rapamycin-eluting stent
The Role of Mammalian Target of Rapamycin in the Early Development of Mouse Zygotes
Efficacy of Rapamycin drug-eluting stents in elderly patients with coronary heart disease
Insights into hepatic carcinogenesis: The effect of Rapamycin on rat liver cell lines
Rapamycin combined with cisplatin in inhibiting the proliferation of ovarian cancer SKOV-3 cells [J]
Development of Selective Inhibitors of the Mammalian Target of Rapamycin
Rapamycin is a potent inhibitor of skin tumor promotion by TPA
Antiproliferative and antiangiogenic effect of Rapamycin on ADPKD cystic lining epithelial cells
Abstract B141: Effects of AZD8055, a novel mTOR kinase inhibitor, in human cancer cells developing resistance to Rapamycin
Abstract A41: Evaluation of maximum tolerated dose of aerosolized Rapamycin in A/J mice
Rapamycin combined with nimuatine suppresses growth and proliferation of human U87MG glioma cells
Effect of mTOR inhibition by Rapamycin on promotion of skin tumors in BK5. Aktwt transgenic mice
Characterization of the Effects and Functions of Sumoylation Through Rapamycin-Mediated Heterodimerization
Black and white: Rapamycin as a regulator of cardiac mTOR signaling
Immunomodulatory Effect of Rapamycin on Innate Immune Response Genes
Clenbuterol increases PGC1a promoter activity via a Rapamycin sensitive mechanism
Active-Site inhibition of the Mammalian Target of Rapamycin
Effect of Rapamycin on cell prolification of glomerular mesangial cells by high glucose
The role of mammalian target of Rapamycin complex 1 in hepatic physiology and disease
Anti-Leukemia Effect of Rapamycin Alone or Plus Daunorubicin on Acute Lymphoblastic Leukemia Cell Lines
Rapamycin reduces primary effusion lymphoma progression by targeting VEGF production and VEGF responses
A Combined Approach of Classical Mutagenesis and Rational Metabolic Engineering for the Improved Production of Rapamycin in Streptomyces hygroscopicus …
Rapamycin-Induced Abundance Changes in the Proteome of Budding Yeast
Inhibitory effect of Rapamycin on human renal tubular epithelial-myofibroblast transition
Rapamycin sensitizes Jurkat T-ALL cells to dexamethasone-induced apoptosis
Effects of Rapamycin on cell proliferation and apoptosis of melanoma B-16 cells
The influence of Rapamycin combined with 5-Aza-cdR to interfere in the in vitro culture of MCF-7 cell line
Mammalian Target of Rapamycin Signaling in Regulation of Aging of Human RPE
The therapeutic value of Rapamycin in a novel mouse model for tuberous scelrosis
Novel therapeutic strategy for breast cancer: mammalian target of Rapamycin inhibition
Effects of Rapamycin on growth and mTOR/4EBP1 Signalling Pathway in Xenograft of Esophageal Squamous Cell Carcinoma
Comparison of Rapamycin and Mitomycin for Reduction of Postoperative Fibrosis After Filtration Surgery in a Rabbit Model
Rapamycin enhances G protein signaling in the budding yeast Saccharomyces Cerevisiae
Pharmacokinetics characterization of Rapamycin ointment in rabbit aqueous humor
Effects of Rapamycin on nephropathy and expression of VEGF and VEGF receptors in PAN nephritic mice [J]
… Rapamycin Combination toward Colon Cancer Cells In vivo and In vitro Is Mediated through Cooperative Modulation of the MammalianTarget of Rapamycin …
The Regulation of STAT1 Nuclear Content by Mammalian Target of Rapamycin
Mammalian Target of Rapamycin Regulates STAT1 Localization in Lung Epithelial Cells.
Rapamycin-Induced Allograft Tolerance: Elucidating Mechanisms and Biomarker Discovery
Rapamycin prevents the post‐exercise increase in protein synthesis and alters cell signaling in human skeletal muscle
The Rapamycin-sensitive phosphoproteome reveals that TOR controls PKA 3 toward some but not all substrates 4
CLONING AND CHARACTERIZATION OF THE PARTIAL Rapamycin-BIOSYNTHETIC GENE CLUSTER FROM ACTINOPLANES SP. N902-109
Expression of mammalian target of Rapamycin/P70S6K in pathologic scars
Rapamycin‐sensitive Co‐localization of mTOR to the Mitotic Spindle
Abstract B143: Distinct antitumor mechanisms of VEGFR inhibitor tivozanib (AV‐951) and mTOR inhibitor Rapamycin support rational combination for solid tumors to …
Effectiveness of Rapamycin drug-eluting stent (Excel stent) in treatment of patients with coronary artery disease
Defining the clinical role of the mammalian target of Rapamycin (mTOR) in lung cancer
BETA-CATENIN TARGET GENES ARE UPREGULATED DURING PARTIAL BLADDER OUTLET OBSTRUCTION AND INHIBITED BY Rapamycin
Effect of Rapamycin on TGF-β1-induced epithelial-mesenchymal transition in LoVo colonic adenocarcinoma cells
Tolerability of the mTOR inhibitor Rapamycin in cirrhotic patients with advanced hepatocellular carcinoma
Clinical Application of Domestic Rapamycin-Eluting Stent in the Emergency Intervention of Acute Coronary Syndrome (ACS)
Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss
Effect of Rapamycin on regulating Toll-like receptor-4 gene expression in rats with acute liver failure
The influence of Rapamycin on expression of CCR7 in the rats with renal fibrosis induced by adriamycin
Rapamycin induces proliferation of CD4~+ CD25~+ FoxP3~+ T regulatory cells in rats
Mammalian target of Rapamycin complex 2 regulates helper T cell differentiation and function (47.31)
BLADDER SMOOTH MUSCLE CELL GROWTH IS MEDIATED BY MAMMALIAN TARGET OF Rapamycin (mTOR)
Expression and significance of phosphorylation-mammalian target of Rapamycin in endometrial carcinoma
High Levels Of Mammalian Target Of Rapamycin (mTOR) In Pulmonary Hypertension
Transscleral Passive Delivery of Rapamycin in Rabbit Using a Visulex® Topical Application Device
Inhibitory effect of Rapamycin on connective tissue growth factor-stimulated cell proliferation and fibronectin secretion in myofibroblasts
Treatment of malignant gliomas with systemic Rapamycin and convection-enhanced delivery of nanoliposomal CPT-11
e0519 Rapamycin suppress KrÜppel-Like Factor 2 expression: mechanism of endothelial dysfunction associated with drug-eluting stents
The mammalian target of Rapamycin inhibitor RAD001 (everolimus) in early breast cancer
Mammalian target of Rapamycin inhibitors for the targeted therapy of non-small cell lung cancer
Chronic Rapamycin Therapy Ameliorates Hypertrophy and Systolic Dysfunction in Severe Chronic Heart Failure Due to Pressure Overload
Physiologic Stimulation Of Bladder Smooth Muscle Cell Growth Is Mediated By Mammalial Target Of Rapamycin (mTOR)
Treatment of Non-left Main Bifurcation Lesions Using the Rapamycin-Eluting Stent
Determination of Encapsulation Efficiency of Rapamycin-loaded Poly (lactic-co-glycolic) acid Nanoparticles by HPLC
Elucidation of chemopreventive effects of aerosolized Rapamycin and dietary myoinositol by mechanistic biomarkers in mouse lung
Expansion of CD3+/CD4+/CD25+/Foxp3+ T cells in Rapamycin-treated lupus patients (143.52)
Mammalian target of Rapamycin (mTOR) inhibitors with therapeutic potential for colitis
PATHOLOGICAL ANGIOGENESIS IN VASCULAR TUMORS IS DRIVEN BY AKT1 AND INHIBITED BY TOPICAL Rapamycin
Combination Of Simvastatin And Rapamycin Abrogates TSC2-null Tumor Growth In Nude Mice And Improves Animal Survival
Pathological angiogenesis in vascular tumors is driven by endothelial Akt1 and inhibited by Rapamycin
Effect of intravenous injection of apoptotic cells combined with Rapamycin on regulatory T cells in rhesus monkey
Rapamycin Inhibits Store-Operated Ca2+ Entry in Cells Isolated from Endarterectomized Tissues of Patients with Chronic Thromboembolic Pulmonary Hypertension.
Immune regulatory effect of Rapamycin and cyclosporine A on experimental corneal allograft survival
Effect of Rapamycin Eluting Stent for inhibition of Neointimal Hyperplasia in Diabetic Porcine Model
Supplemental Information Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
Effects of high glucose and Rapamycin intervention on expression of type Ⅳ collagen and matrix metalloproteinase-9 in podocytes
Cigarette Smoke And Rapamycin Up-regulate Matrix Metalloproteinase-1 Expression In Endothelial Cells Through mTOR Activation
Preparation and in vitro release study of Rapamycin in poly (lactic-co-glycolic) acid microsphere for topical administration
PDGFR alpha is overexpressed in synovial sarcomas and can mediate Rapamycin induced Akt activation
Enhanced tumor cytotoxicity of a combinational therapy using liposomal copper-doxorubicin, Rapamycin, and ultrasound
Rapamycin-CONDITIONED HUMAN DENDRITIC CELLS EXHIBIT INCREASED IL-12P70 PRODUCTION UPON EXPOSURE TO PRO-INFLAMMATORY …
Rapamycin eye drops inhibit rat corneal neovascularization: Role of vascular endothelial growth factor and inflammatory factor☆
The mammalian target of Rapamycin signaling pathway in bovine mammary epithelial cells
Characterisation of the effects and mechanism of action of Rapamycin and genistein on acute myeloid leukemia using high-throughput techniques
New Drug Development in Sarcoma: Exploration of Novel Targets, Particularly the Mammalian Target of Rapamycin (mTOR) Pathway
45A: TARGETED SITE SPECIFIC IMMUNOSUPPRESSION WITH TOPICAL Rapamycin AND MYCOPHENOLIC ACID IN COMPOSITE TISSUE …
1, 4-phenylenebis (methylene) selenocyanate (p-XSC) inhibits mammalian target of Rapamycin complex 2 (mTORC2) signaling in prostate cancer cells
Pre-clinical and Clinical Study Results for the Coracto™ Rapamycin-eluting Stent–A New-generation Drug-eluting Stent
The Protective Effect of mammalian Target of Rapamycin (mTOR) in Cisplatin Induced Nephropathy
Contact-dependent suppression pathways in non-human primate Tregs expanded ex vivo in the presence of Rapamycin (141.36)
The effects of l-leucine, contractions, and Rapamycin on the Akt/mTOR pathway in rat skeletal muscle
Rapamycin IMPAIRS PROLIFERATION OF TRANSPLANTED ISLET BETA CELLS: 791
Rapamycin inhibits epidermal cell proliferation in a xenograft model of tuberous sclerosis skin tumors
Effect of the combination of retinoic acid and Rapamycin on cerebellar granule cell and medulloblastoma proliferation
Nutrient signaling, mammalian target of Rapamycin and ovine conceptus development
Effect of combination of CCR5 antisense peptide nucleic acid and lose-dose Rapamycin on islet allograft survival
Rapamycin inhibits cyst growth, IGF-1-mediated VEGF secretion and cell proliferation in polycystin-2 defective mice
Is Oral Rapamycin Plus Bare Metal Stents a Feasible Alternative to Drug‐Eluting Stents? Lessons Learned from Argentina Observational and Randomized Studies …
Rapamycin-Induced Autophagy Generates Anti-Apoptotic Th1/Tc1 Cells That Mediate Increased Xenogeneic Gvhd.
Rapamycin impairs metabolism-secretion coupling in rat pancreatic islets by suppressing carbohydrate metabolism in the Krebs cycle
Combination of antagonists of growth hormone-releasing hormone antagonist (GHRH) with Rapamycin as a potential therapy in human breast cancers.
Role of mammalian target of Rapamycin signalling in bone destruction by gingival squamous cell carcinoma
Rapamycin potentiates the effects of paclitaxel in uterine papillary serous carcinoma (UPSC) cells through inhibition of cell proliferation and induction of apoptosis
Symbol Effect of Rapamycin-poly (lactide-acid)/magnetic microsphere composite materials on the proliferation of vascular smooth muscle cells
Retinoblastoma Tumor Burden Control: Periocular m-TOR Inhibitor Rapamycin Decreases Tumor Burden in Advanced LHBETATAG Murine Retinoblastoma
Effects of Mycophenolic Acid and Rapamycin on Toll-like Receptor Expression in Hypoxic Human Proximal Tubular Epithelial Cells
The Impact of Iron Deficiency During Development on Mammalian Target of Rapamycin Signaling, Neuronal Structure, and Learning and Memory Behavior
Mammalian Target of Rapamycin: A Bump in the Pathway to NF-κB Activation and ICAM-1 Expression in Endothelial Cells.
Increased Frequency Of Regulatory T-Cells And Selection Of Highly Potent CD62L+ Cells During Treatment Of Human Lung Recipients With Rapamycin
The IGF-1 receptor targeting antibody, CP-751,871, suppresses tumor-derived VEGF and synergizes with Rapamycin in models of childhood sarcoma
Targeting mammalian target of Rapamycin (mTOR) signaling in the Han: SPRD rat, a model for polycystic kidney disease
Chemical Genetic Dissection of TOR Signaling Through Identification and Characterization of Small Molecule Enhancers of Rapamycin
Mammalian Target of Rapamycin Signaling and the Suprachiasmatic Circadian Clock
Abstract# 3712: OXA-01, a novel potent mTORC1/TORC2 inhibitor displays improved anti-tumor activity in comparison to Rapamycin, an mTORC1 selective inhibitor
inhibition of mammalian target of Rapamycin induces phenotypic reversion in three-dimensional cultures of malignant breast epithelial cells
Rapamycin mediated inhibition of mTOR prevents postprandial activation of the unfolded protein response and upregulation of fatty acid synthase
Distinct phosphatase requirements and GATA factor responses to nitrogen catabolite repression and Rapamycin treatment in S. cerevisiae
Use of Rapamycin Reveals Evidence of the Physiological Roles of FKBP12 and FKBP12. 6 In Cardiac Excitation-Contraction Coupling
e0520 Statin effects in stent thrombosis induced by Rapamycin releasing from drug-eluting stents through KrÜppel-Like Factor 2 overexpression
Rapamycin enhanced in vitro and in vivo activity of dexamethasone against acute lymphoblastic leukemia and lymphoma preclincal models via inhibition of p70S6 …
Human T Cell Rapamycin Resistance And Th1/Tc1 Polarization Augment Xenogeneic Graft-Versus-Host Disease
Abstract# 4363: inhibition of mammalian target of Rapamycin (mTOR) in advanced pancreatic cancer-the results of two prospective phase II studies.
In vitro enhancing oxidative phosphorylation by Rapamycin in proliferative CD8+ T cells during antigenic priming augments the generation of long-lived memory T cells …
Comparasion of therapeutic effects of Chinese Rapamycin-eluting stent and imported paclitaxel-eluting stent in treatment of acute myocardial infarction
Generation of tolerogenic human DC through Rapamycin conditioning and genetic modification with HLA-G.
Prolonged Exposure of Myeloid Dendritic Cells To Rapamycin enhances LPS-induced IL-12p70 production, but does not promote Th1 responses (141.29)
The mammalian target of Rapamycin mediates the angiogenic and chemotactic effects of leptin in human hepatic stellate cells.
Calorie restriction and Rapamycin, but not exercise, inhibit MMTV-Wnt-1 mammary tumor growth in a mouse model of postmenopausal obesity
Abstract# LB-135: Grapefruit juice significantly increases bioavailability of weekly Rapamycin (sirolimus)-evidence of safety and activity in a phase 1 study
Mammalian Target of Rapamycin (mTOR)-mediated Effect on Disease Progression in Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Vitamin K_3 induces autophagy in HeLa cells through downregulating the mammalian target of Rapamycin (mTOR) pathway
Pharmacodynamic (PD) study of pre-prostatectomy Rapamycin in men with advanced localized prostate cancer (PC): A DOD Prostate Cancer Clinical Trials …
Effects of high-fat vs. low-fat diets on mammalian target of Rapamycin signaling and metabolic measures in spontaneously hypertensive rats
Anti-liver fibrotic effect of Salvia miltiorthiza and Shugan-Huayu powder combining with or without Rapamycin in animal models.
Rapidly Inducible Protein Modification Using Rapamycin-mediated Complementation Of Tobacco Etch Virus (TEV) Protease
Modulatory Role of Mammalian Target of Rapamycin in Regulating Endothelial ICAM‐1 Expression and Lung PMN Recruitment
Erratum: Mammalian target of Rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial …
Rapamycin AND MYCOPHENOLIC ACID, BUT NOT CYCLOSPORIN A, IMPAIR HUMAN NK CELL CYTOLYTIC ACTIVITY DUE TO DIFFERENTIAL EFFECTS ON …
198 Modulation of CCR5 density with low doses of the transplant drug Rapamycin sensitizes Vicriviroc-resistant R5 HIV-1
Rapamycin and IL-2 Prevents Lethal Acute Graft-Versus Host Disease by Expansion of Donor Type CD4+CD25+Foxp3+ Regulatory T Cells.
Abstract# 4648: Rapamycin inhibits tube formation of lymphatic endothelial cells by targeting TORC1-mediated expression of Flt4
Abstract LB-74: A high-throughput RNAi sensitization screen of Rapamycin identifies targets for rational drug combination strategies
Abstract# 2770: Over-expression of the mammalian target of Rapamycin (mTOR): a novel biomarker for poor survival in resected early stage non-small cell lung cancer
Abstract# 2014: ATP competitive inhibitors of the mammalian target of Rapamycin (mTOR): Design and synthesis of novel, highly selective pyrazolopyrimidines with …
The Mammalian Target of Rapamycin (mTOR) Is a Novel Regulator of HMW-Hyaluronan-Mediated Pulmonary Endothelial Barrier Enhancement.
COMBINED ADMINISTRATION OF A NOVEL MUTANT TGF-β1/FC AND Rapamycin MODULATES THE IMMUNE BALANCE BETWEEN TREG AND TH17 AND …
CD28: FC AND Rapamycin CAN PREVENT TH17-MEDIATED ALLOGRAFT REJECTION IN MOUSE PANCREATIC ISLET TRANSPLANTATION MODEL: 700
Androgen receptor antagonist bicalutamide sensitizes androgen-independent prostate cancer cells to mTOR inhibitor Rapamycin by regulating phosphorylation of …
Abstract# 1735: Rapamycin inhibits hyperactivation of mTORC1 signaling in a novel xenograft model of tuberous sclerosis complex skin tumors
ET-29. ONCOLYTIC VIRUS COMBINED WITH Rapamycin TARGETING BRAIN TUMOR-INITIATING CELLS
… Multicenter phase I clinical trial of an insulin like growth factor (IGF‐R) inhibitor (IMC‐A12) in combination with a mammalian target of Rapamycin (mTOR) inhibitor (CCI …
Mouse Oocytes Promote the Mechanistic Target of Rapamycin (Serine/Threonine Kinase, mTOR) Pathway in Cumulus Cells by Suppressing the Expression of DNA …
… oral protein: time‐dependent concordance/discordance between muscle protein synthesis (MPS) and mammalian target of Rapamycin (mTOR)‐associated signaling
Relationship between expression of mutant type glutathione S-transferase theta-1 gene and reactivity of Rapamycin in myelodysplastic syndrome
Rapamycin CONDITIONED DENDRITIC CELLS FOR IN VITRO DIFFERENTIATION OF DONOR-SPECIFIC CD4+ CD25+ FOXP3+ REGULATORY T CELLS FOR …
… DEVELOPMENT OF CD8+ CD44+ CD62L+ MEMORY T CELLS PROMOTE SPECIFIC TOLERANCE TO CARDIAC ALLOGRAFTS FOLLOWING Rapamycin …
Abstract# 4050: Increased cytotoxicity with nifurtimox and Rapamycin combination therapy in neuroblastoma.
The Effect of Insulin-like Growth Factor 1 (IGF-1) and Exercise on the Protein Expression of Mammalian Target of Rapamycin (mTOR) and Androgen Receptor (AR) in …
Abstract# 3711: Superior cellular anti-tumor effects of a dual mTORC1/mTORC2 kinase inhibitor OXA-01 relative to the mTORC1 inhibitor Rapamycin
Erratum 2: Testosterone induces cardiomyocyte hypertrophy through mammalian target of Rapamycin complex 1 pathway
Erratum 2: Testosterone induces cardiomyocyte hypertrophy through mammalian target of Rapamycin complex 1 pathway (vol 202, pg 299, 2009)
Abstract# 156: Is irinotecan and Rapamycin combination, targeting mTOR/HIF-1 alpha axis, a new effective therapy in high grade brain tumors?
Intra-Nuclear Function for PP2A Phosphatase: Pph21/22 Are Required for Rapamycin-Induced GATA Factor Binding to the DAL5 Promoter in Yeast
Activating transcription factor 4 negatively regulates the mammalian target of Rapamycin via Redd1 expression in response to 2-deoxyglucose
Abstract# 5237: The combination of Rapamycin and bicalutamide induce apoptosis in prostate cancer cells by simultaneously inhibiting the mTORC1/eIF4 and AR …
TORC1/2 inhibitors have more potent anti-leukemic efficacy and are less immunosuppressive than Rapamycin
Abstract# 2824: The Src inhibitor AZD0530 enhances the anti-tumor effect of Rapamycin in hepatocellular carcinoma (HCC) cells
Abstract LB-159: An orthotopic model of head and neck squamous carcinoma reveals that mTOR inhibition with Rapamycin halts lymph node metastasis
Abstract# 3842: High expression of mTOR (mammalian target of Rapamycin) is associated with better outcome in non-small cell lung cancer
Abstract# 1079: CD133 expression is affected by Rapamycin in cancer cells.
Abstract# 2879: inhibition of mammalian target of Rapamycin as a therapeutic strategy in the management of bladder cancer
Abstract# 3757: Antiproliferative effects of Rapamycin and doxorubicin combination on human Erbb2 overexpressing breast epithelial cell lines.
Abstract# 2818: Growth inhibition of human breast cancer cells with an iron chelator and a dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor
Abstract# 2302: NVP-BEZ235 a dual inhibitor of phosphatidylinositol 3-Kinase (PI3 Kinase) and mammalian target of Rapamycin (mTOR) potently enhances the effects …
Liposomal KRN7000 (RGI-2001) Synergizes with Low-Dose Rapamycin in Preventing GvHD by promoting expansion of naturally-Occurring CD4+FOXP3+ …
Abstract P3-14-17: Trastuzumab (H) and Rapamycin (R) for Treatment of HER-2 Overexpressing Metastatic Breast Cancer (BC) with Prior Disease Progression on H …
… : HQO-0601, an amide-containing 3, 4-dihydroquinolinone derivative, against human hematologic malignancies through inhibition of mammalian target of Rapamycin …
Rapamycin slows aging in mice
Fighting neurodegeneration with Rapamycin: mechanistic insights
Target of Rapamycin (TOR) in nutrient signaling and growth control
Rapamycin and glucose-target of Rapamycin (TOR) protein signaling in plants
Rapamycin passes the torch: a new generation of mTOR inhibitors
Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity
Autophagy activation by Rapamycin reduces severity of experimental osteoarthritis
Protein translocation as a tool: The current Rapamycin story
Relieving autophagy and 4EBP1 from Rapamycin resistance
Chronic inhibition of mammalian target of Rapamycin by Rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice
Paradoxical aspects of Rapamycin immunobiology in transplantation
Rapamycin and mTOR: a serendipitous discovery and implications for breast cancer
Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice
TOR signaling and Rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO
Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders
The mammalian target of Rapamycin regulates cholesterol biosynthetic gene expression and exhibits a Rapamycin-resistant transcriptional profile
A photocleavable Rapamycin conjugate for spatiotemporal control of small GTPase activity
Target of Rapamycin signaling regulates metabolism, growth, and life span in Arabidopsis
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice
Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex
Rapamycin and other longevity‐promoting compounds enhance the generation of mouse induced pluripotent stem cells
mTOR and Rapamycin in the kidney: signaling and therapeutic implications beyond immunosuppression
Inducing autophagy by Rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits
… enhances the anti-tumor activity of the mTOR inhibitor Rapamycin in multiple breast cancer cell lines mainly by suppressing Rapamycin-induced AKT signaling
Common toxicities of mammalian target of Rapamycin inhibitors
Topical Rapamycin therapy to alleviate the cutaneous manifestations of tuberous sclerosis complex
Rapamycin treatment augments motor neuron degeneration in SOD1G93A mouse model of amyotrophic lateral sclerosis
Activating mutations of TOR (target of Rapamycin)
Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells
Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function
Mammalian target of Rapamycin: a signaling kinase for every aspect of cellular life
Mammalian target of Rapamycin: a central node of complex signaling cascades
Induction of tolerance to factor VIII by transient co‐administration with Rapamycin
Once again on Rapamycin-induced insulin resistance and longevity: despite of or owing to
Haploinsufficiency of target of Rapamycin attenuates cardiomyopathies in adult zebrafish
Stability of human Rapamycin-expanded CD4+ CD25+ T regulatory cells
Autophagy and cardiovascular aging: lesson learned from Rapamycin
Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/− mice
A pulse Rapamycin therapy for infantile spasms and associated cognitive decline
Hyperplexing: a method for higher-order multiplexed quantitative proteomics provides a map of the dynamic response to Rapamycin in yeast
Rapamycin protects against myocardial ischemia–reperfusion injury through JAK2–STAT3 signaling pathway
Mammalian target of Rapamycin and the kidney. I. The signaling pathway
The ketogenic diet inhibits the mammalian target of Rapamycin (mTOR) pathway
Preventive and therapeutic effects of Rapamycin, a mammalian target of Rapamycin inhibitor, on food allergy in mice
Shedding new light on neurodegenerative diseases through the mammalian target of Rapamycin
Lifelong Rapamycin administration ameliorates age‐dependent cognitive deficits by reducing IL‐1β and enhancing NMDA signaling
Mammalian target of Rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
Mammalian target of Rapamycin signaling in diabetic cardiovascular disease
Rapamycin promotes autophagy and reduces neural tissue damage and locomotor impairment after spinal cord injury in mice
Folate-conjugated Rapamycin slows progression of polycystic kidney disease
Mammalian target of Rapamycin (mTOR) signaling network in skeletal myogenesis
Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy
Chronic mTOR inhibition by Rapamycin induces muscle insulin resistance despite weight loss in rats
Wound healing complications and the use of mammalian target of Rapamycin inhibitors in kidney transplantation: a critical review of the literature
Rapamycin increases oxidative stress response gene expression in adult stem cells
inhibition of mammalian target of Rapamycin reduces epileptogenesis and blood–brain barrier leakage but not microglia activation
Rapamycin As an Antiaging Therapeutic?: Targeting Mammalian Target of Rapamycin to Treat Hutchinson–Gilford Progeria and Neurodegenerative Diseases
Successful treatment of angiofibromata of tuberous sclerosis complex with Rapamycin
Rapamycin protects against middle cerebral artery occlusion induced focal cerebral ischemia in rats
Rapamycin Causes Upregulation of Autophagy and Impairs Islets Function Both In Vitro and In Vivo
Therapeutic role of mammalian target of Rapamycin (mTOR) inhibition in preventing epileptogenesis
Monitoring autophagic flux by an improved tandem fluorescent-tagged LC3 (mTagRFP-mWasabi-LC3) reveals that high-dose Rapamycin impairs autophagic flux in …
Prevention of age-related macular degeneration–like retinopathy by Rapamycin in Rats
Mammalian target of Rapamycin: a valid therapeutic target through the autophagy pathway for Alzheimer’s disease?
The interaction between early life epilepsy and autistic-like behavioral consequences: a role for the mammalian target of Rapamycin (mTOR) pathway
Current and future directions in mammalian target of Rapamycin inhibitors development
Gli inhibitor GANT61 causes apoptosis in myeloid leukemia cells and acts in synergy with Rapamycin
Target of Rapamycin regulates development and ribosomal RNA expression through kinase domain in Arabidopsis
Mammalian target of Rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acids
The PI3K/Akt/mTOR pathway is activated in murine lupus nephritis and downregulated by Rapamycin
inhibition of mammalian target of Rapamycin augments lipopolysaccharide-induced lung injury and apoptosis
New nanoformulation of Rapamycin Rapatar extends lifespan in homozygous p53−/− mice by delaying carcinogenesis
Combinatorial effects of lapatinib and Rapamycin in triple-negative breast cancer cells
Phase II study of the mammalian target of Rapamycin inhibitor ridaforolimus in patients with advanced bone and soft tissue sarcomas
Impaired autophagy in neurons after disinhibition of mammalian target of Rapamycin and its contribution to epileptogenesis
Rapamycin delays disease onset and prevents PrP plaque deposition in a mouse model of Gerstmann–Sträussler–Scheinker disease
Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of Rapamycin (mTOR) complex 2
Rapamycin reverses elevated mTORC1 signaling in lamin A/C–deficient mice, rescues cardiac and skeletal muscle function, and extends survival
Retinoic acid and Rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells
Rapamycin increases rDNA stability by enhancing association of Sir2 with rDNA in Saccharomyces cerevisiae
Review of cytomegalovirus infection findings with mammalian target of Rapamycin inhibitor-based immunosuppressive therapy in de novo renal transplant recipients
Low‐Dose Rapamycin Treatment Increases the Ability of Human Regulatory T Cells to Inhibit Transplant Arteriosclerosis In Vivo
Stable isotope-labelling analysis of the impact of inhibition of the mammalian target of Rapamycin on protein synthesis
Managing stomatitis in patients treated with Mammalian target of Rapamycin inhibitors.
Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome–associated PTPN11 mutation
Rapamycin blocks production of KSHV/HHV8: insights into the anti-tumor activity of an immunosuppressant drug
inhibition of mechanistic target of Rapamycin promotes dendritic cell activation and enhances therapeutic autologous vaccination in mice
Therapeutic value of prenatal Rapamycin treatment in a mouse brain model of tuberous sclerosis complex
Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage
Rapamycin slows aging in mice
Amino acids activate mammalian target of Rapamycin complex 2 (mTORC2) via PI3K/Akt signaling
Suppression of replicative senescence by Rapamycin in rodent embryonic cells
inhibition of the mammalian target of Rapamycin blocks epilepsy progression in NS‐Pten conditional knockout mice
The mTOR inhibitor Rapamycin suppresses DNA double-strand break repair
Autophagy stimulation by Rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis
Rapamycin for treatment of type I autosomal dominant polycystic kidney disease (RAPYD-study): a randomized, controlled study
Differing effects of Rapamycin or calcineurin inhibitor on T‐regulatory cells in pediatric liver and kidney transplant recipients
Neuronal and glia abnormalities in Tsc1-deficient forebrain and partial rescue by Rapamycin
Post-treatment with Rapamycin does not prevent epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy
Mammalian target of Rapamycin and the kidney. II. Pathophysiology and therapeutic implications
Rapamycin inhibits proliferation of hemangioma endothelial cells by reducing HIF-1-dependent expression of VEGF
Optimization of Rapamycin-loaded acetalated dextran microparticles for immunosuppression
Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity
Mammalian target of Rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1 α
Stress-responsive sestrins link p53 with redox regulation and mammalian target of Rapamycin signaling
Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons
Oral Rapamycin in the treatment of patients with hamartoma syndromes and PTEN mutation
Oral adverse events associated with tyrosine kinase and mammalian target of Rapamycin inhibitors in renal cell carcinoma: a structured literature review
Efficacy and safety of sorafenib in combination with mammalian target of Rapamycin inhibitors for recurrent hepatocellular carcinoma after liver transplantation
Involvement of the mammalian target of Rapamycin signaling in the antidepressant-like effect of group II metabotropic glutamate receptor antagonists
N‐acetylcysteine reduces disease activity by blocking mammalian target of Rapamycin in T cells from systemic lupus erythematosus patients: A randomized, double …
… lactate dehydrogenase predicts for overall survival benefit in patients with metastatic renal cell carcinoma treated with inhibition of mammalian target of Rapamycin
Antitumor activity of Triolimus: a novel multidrug-loaded micelle containing Paclitaxel, Rapamycin, and 17-AAG
Rapamycin-induced glucose intolerance: hunger or starvation diabetes
Induction of biogenic magnetization and redox control by a component of the target of Rapamycin complex 1 signaling pathway
Rapamycin resistance is linked to defective regulation of Skp2
Rapamycin ameliorates kidney fibrosis by inhibiting the activation of mTOR signaling in interstitial macrophages and myofibroblasts
Roles of the mammalian target of Rapamycin, mTOR, in controlling ribosome biogenesis and protein synthesis
The mTOR inhibitor Rapamycin has limited acute anticonvulsant effects in mice
Multiple roles for mammalian target of Rapamycin signaling in both glutamatergic and GABAergic synaptic transmission
Rapamycin suppresses self-renewal and vasculogenic potential of stem cells isolated from infantile hemangioma
Rapamycin-induced enhancement of vaccine efficacy in mice
Regulating mammalian target of Rapamycin to tune vaccination-induced CD8+ T cell responses for tumor immunity
Biosynthesis of the immunosuppressants FK506, FK520, and Rapamycin involves a previously undescribed family of enzymes acting on chorismate
A comprehensive review of everolimus clinical reports: a new mammalian target of Rapamycin inhibitor
Selective activation of Akt1 by mammalian target of Rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis
Rab5 proteins regulate activation and localization of target of Rapamycin complex 1
Mutations in the Arabidopsis homolog of LST8/GβL, a partner of the target of Rapamycin kinase, impair plant growth, flowering, and metabolic adaptation to long days
Mammalian target of Rapamycin (mTOR) inhibition: potential for antiseizure, antiepileptogenic, and epileptostatic therapy
Expanding human T regulatory cells with the mTOR-inhibitor Rapamycin
Effects of Rapamycin and TOR on aging and memory: implications for Alzheimer’s disease
Naturally secreted amyloid-β increases mammalian target of Rapamycin (mTOR) activity via a PRAS40-mediated mechanism
Phospholipase D mediates nutrient input to mammalian target of Rapamycin complex 1 (mTORC1)
Rapamycin activates autophagy in Hutchinson-Gilford progeria syndrome: implications for normal aging and age-dependent neurodegenerative disorders
Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of Rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2
Rapamycin induces Bad phosphorylation in association with its resistance to human lung cancer cells
Mycobacterial induction of autophagy varies by species and occurs independently of mammalian target of Rapamycin inhibition
Third target of Rapamycin complex negatively regulates development of quiescence in Trypanosoma brucei
Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2)
Rapamycin attenuates airway hyperreactivity, goblet cells, and IgE in experimental allergic asthma
mTOR inhibition with Rapamycin causes impaired insulin signalling and glucose uptake in human subcutaneous and omental adipocytes
Progeria, Rapamycin and normal aging: recent breakthrough
Resveratrol inhibits inflammatory responses via the mammalian target of Rapamycin signaling pathway in cultured LPS-stimulated microglial cells
High-dose Rapamycin induces apoptosis in human cancer cells by dissociating mTOR complex 1 and suppressing phosphorylation of 4E-BP1
Systemic inhibition of the mammalian target of Rapamycin (mTOR) pathway reduces neuropathic pain in mice
The differential effects of prenatal and/or postnatal Rapamycin on neurodevelopmental defects and cognition in a neuroglial mouse model of tuberous sclerosis …
Induction of autophagy by palmitic acid via protein kinase C-mediated signaling pathway independent of mTOR (mammalian target of Rapamycin)
Nucleolar disruption in dopaminergic neurons leads to oxidative damage and parkinsonism through repression of mammalian target of Rapamycin signaling
Rapamycin and IL-2 reduce lethal acute graft-versus-host disease associated with increased expansion of donor type CD4+CD25+Foxp3+ regulatory T cells
The mTOR kinase inhibitor Rapamycin decreases iNOS mRNA stability in astrocytes
Insulin-like peptides and the target of Rapamycin pathway coordinately regulate blood digestion and egg maturation in the mosquito Aedes aegypti
Heightened uterine mammalian target of Rapamycin complex 1 (mTORC1) signaling provokes preterm birth in mice
inhibition of the mammalian target of Rapamycin pathway by Rapamycin blocks cocaine-induced locomotor sensitization
Tolerance induction by exosomes from immature dendritic cells and Rapamycin in a mouse cardiac allograft model
Rapamycin is a potent inhibitor of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate
Characterization of the metabolic phenotype of Rapamycin-treated CD8+ T cells with augmented ability to generate long-lasting memory cells
Light regulation of protein dimerization and kinase activity in living cells using photocaged Rapamycin and engineered FKBP
Mammalian target of Rapamycin signaling is a key regulator of the transit-amplifying progenitor pool in the adult and aging forebrain
Metformin promotes progesterone receptor expression via inhibition of mammalian target of Rapamycin (mTOR) in endometrial cancer cells
A critical role for non-coding RNA GAS5 in growth arrest and Rapamycin inhibition in human T-lymphocytes
Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of Rapamycin complex 1 (mTORC1) signaling
Dramatic improvement of facial angiofibromas in tuberous sclerosis with topical Rapamycin: optimizing a treatment protocol
Mapping the spatio-temporal pattern of the mammalian target of Rapamycin (mTOR) activation in temporal lobe epilepsy
Rapamycin inhibits lymphatic endothelial cell tube formation by downregulating vascular endothelial growth factor receptor 3 protein expression
Anticancer peptidylarginine deiminase (PAD) inhibitors regulate the autophagy flux and the mammalian target of Rapamycin complex 1 activity
Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor
Mammalian target of Rapamycin complex 1 (mTORC1) and 2 (mTORC2) control the dendritic arbor morphology of hippocampal neurons
Mammalian target of Rapamycin complex 2 (mTORC2) negatively regulates Toll-like receptor 4-mediated inflammatory response via FoxO1
Proteomic identification of novel targets regulated by the mammalian target of Rapamycin pathway during oligodendrocyte differentiation
Phosphoproteomic profiling of in vivo signaling in liver by the mammalian target of Rapamycin complex 1 (mTORC1)
The influence of co-solvents on the stability and bioavailability of Rapamycin formulated in self-microemulsifying drug delivery systems
Altered APP processing in insulin-resistant conditions is mediated by autophagosome accumulation via the inhibition of mammalian target of Rapamycin pathway
Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2
Rapamycin attenuates aggressive behavior in a rat model of pilocarpine-induced epilepsy
inhibition of mTOR by Rapamycin in the amygdala or hippocampus impairs formation and reconsolidation of inhibitory avoidance memory
Convergence of the mammalian target of Rapamycin complex 1-and glycogen synthase kinase 3-β–signaling pathways regulates the innate inflammatory response
Rapamycin for Treatment of Epilepsy: Antiseizure, Antiepileptogenic, Both, or Neither? Rapamycin for Treatment of Epilepsy
Rapamycin reduces clinical signs and neuropathic pain in a chronic model of experimental autoimmune encephalomyelitis
Stimulation of autophagy by Rapamycin protects neurons from remote degeneration after acute focal brain damage
The physiology and pathophysiology of Rapamycin resistance: implications for cancer
Combination therapy targeting Akt and mammalian target of Rapamycin improves functional outcome after controlled cortical impact in mice
Rapamycin paradox resolved
Combining mTOR inhibitors with Rapamycin-resistant T cells: a two-pronged approach to tumor elimination
Circadian regulation of mammalian target of Rapamycin signaling in the mouse suprachiasmatic nucleus
Mammalian Target of Rapamycin (mTOR) Inhibitors
Dietary restriction but not Rapamycin extends disease onset and survival of the H46R/H48Q mouse model of ALS
Rapamycin with antiretroviral therapy in AIDS-associated Kaposi sarcoma: an AIDS Malignancy Consortium study
Rapamycin reduces reactive oxygen species in cultured human corneal endothelial cells
mTOR-dependent regulation of PHLPP expression controls the Rapamycin sensitivity in cancer cells
Mammalian target of Rapamycin integrates diverse inputs to guide the outcome of antigen recognition in T cells
Targeting the mammalian target of Rapamycin (mTOR) in cancer therapy: lessons from past and future perspectives
… mechanism of atorvastatin to protect mesenchymal stem cells from hypoxia and serum deprivation via AMP-activated protein kinase/mammalian target of Rapamycin …
Consolidation and reconsolidation of contextual fear memory requires mammalian target of Rapamycin-dependent translation in the dorsal hippocampus
Effects of cyclosporine, tacrolimus and Rapamycin on renal calcium transport and vitamin D metabolism
AMP-dependent kinase/mammalian target of Rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications
Ghrelin contributes to derangements of glucose metabolism induced by Rapamycin in mice
TORC1 of fission yeast is Rapamycin‐sensitive
Target-of-Rapamycin complex 1 (Torc1) signaling modulates cilia size and function through protein synthesis regulation
Therapy of sclerodermatous chronic graft-versus-host disease with mammalian target of Rapamycin inhibitors
The tuberous sclerosis complex–mammalian target of Rapamycin pathway maintains the quiescence and survival of naive T cells
Low dose Rapamycin exacerbates autoimmune experimental uveitis
Rapamycin impairs proliferation of transplanted islet β cells
The role of mammalian target of Rapamycin (mTOR) in the regulation of pancreatic β-cell mass: implications in the development of type-2 diabetes
Observations on enhanced port wine stain blanching induced by combined pulsed dye laser and Rapamycin administration
Kinome-wide selectivity profiling of ATP-competitive mammalian target of Rapamycin (mTOR) inhibitors and characterization of their binding kinetics
Adiponectin induces vascular smooth muscle cell differentiation via repression of mammalian target of Rapamycin complex 1 and FoxO4
Activation of PI3K/AKT and MAPK pathway through a PDGFRβ-dependent feedback loop is involved in Rapamycin resistance in hepatocellular carcinoma
Cannabinoid receptor agonists modulate oligodendrocyte differentiation by activating PI3K/Akt and the mammalian target of Rapamycin (mTOR) pathways
Redox regulates mammalian target of Rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway
Campylobacter jejuni induces colitis through activation of mammalian target of Rapamycin signaling
Mechanistic target of Rapamycin inhibitors in solid organ transplantation: from benchside to clinical use
Dihydroartemisinin ameliorates inflammatory disease by its reciprocal effects on Th and regulatory T cell function via modulating the mammalian target of Rapamycin …
Differing effects of Rapamycin and mTOR kinase inhibitors on protein synthesis
Coupling nutrient sensing to metabolic homoeostasis: the role of the mammalian target of Rapamycin complex 1 pathway
Impairment of object recognition memory by Rapamycin inhibition of mTOR in the amygdala or hippocampus around the time of learning or reactivation
Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of Rapamycin (mTOR) kinase inhibitor (GDC-0980) …
Phosphatidic acid activates mammalian target of Rapamycin complex 1 (mTORC1) kinase by displacing FK506 binding protein 38 (FKBP38) and exerting an …
A topical combination of Rapamycin and tacrolimus for the treatment of angiofibroma due to tuberous sclerosis complex (TSC): a pilot study of nine Japanese patients …
Assessing the effectiveness of Rapamycin on angiomyolipoma in tuberous sclerosis: a two years trial
Resveratrol inhibits cancer cell metabolism by down regulating pyruvate kinase M2 via inhibition of mammalian target of Rapamycin
Rapamycin partially mimics the anticancer effects of calorie restriction in a murine model of pancreatic cancer
PDGF receptor alpha is an alternative mediator of Rapamycin-induced Akt activation: implications for combination targeted therapy of synovial sarcoma
The emerging role of mammalian target of Rapamycin inhibitors in the treatment of sarcomas
Differential effects of Rapamycin on rods and cones during light-induced stress in albino mice
Evaluation of Rapamycin-induced cell death
Rapid cytoplasmic turnover of yeast ribosomes in response to Rapamycin inhibition of TOR
… mammalian target of Rapamycin (mTOR) inhibitor activates extracellular signal-regulated kinase (ERK) in multiple myeloma cells via a target of Rapamycin …
Rapamycin attenuates the expression of cocaine‐induced place preference and behavioral sensitization
The mammalian target of Rapamycin inhibitor everolimus (RAD001) in early breast cancer: results of a pre-operative study
L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of Rapamycin
Starvation and Rapamycin differentially regulate host cell lysosome exocytosis and invasion by Trypanosoma cruzi metacyclic forms
Paradoxical effects of Rapamycin on experimental house dust mite-induced asthma
Magnetic nanoparticles and Rapamycin encapsulated into polymeric nanocarriers
Rapamycin inhibits osteolysis and improves survival in a model of experimental bone metastases
Rapamycin synergizes cisplatin sensitivity in basal-like breast cancer cells through up-regulation of p73
Rapamycin inhibits transforming growth factor β‐induced peritoneal angiogenesis by blocking the secondary hypoxic response
Calorie restriction and Rapamycin inhibit MMTV-Wnt-1 mammary tumor growth in a mouse model of postmenopausal obesity
Facial angiofibromas treated with topical Rapamycin: an excellent choice with fast response
Rapamycin blocks hepatoblastoma growth in vitro and in vivo implicating new treatment options in high-risk patients
Regulatory T cells require mammalian target of Rapamycin signaling to maintain both homeostasis and alloantigen-driven proliferation in lymphocyte-replete mice
Spinal cord NMDA receptor-mediated activation of mammalian target of Rapamycin is required for the development and maintenance of bone cancer-induced pain …
SIRT1 is required for the effects of Rapamycin on high glucose-inducing mesangial cells senescence
The Akt/mammalian target of Rapamycin pathway is activated and associated with adverse prognosis in soft tissue leiomyosarcomas
inhibition of Rapamycin-induced autophagy causes necrotic cell death associated with Bax/Bad mitochondrial translocation
Emerging roles for mammalian target of Rapamycin inhibitors in the treatment of solid tumors and hematological malignancies
An increase in basal BDNF provokes hyperactivation of the Akt-mammalian target of Rapamycin pathway and deregulation of local dendritic translation in a mouse …
Novel synergistic antitumor effects of Rapamycin with bortezomib on hepatocellular carcinoma cells and orthotopic tumor model
Mammalian target of Rapamycin regulates isoliquiritigenin-induced autophagic and apoptotic cell death in adenoid cystic carcinoma cells
The mechanism of mTOR (mammalian target of Rapamycin) in a mouse model of polycystic ovary syndrome (PCOS)
Discovery and optimization of a series of benzothiazole phosphoinositide 3-kinase (PI3K)/mammalian target of Rapamycin (mTOR) dual inhibitors
Mammalian target of Rapamycin signaling in the podocyte
Transcriptional regulation of gene expression during osmotic stress responses by the mammalian target of Rapamycin
Mao-B elevation decreases parkin’s ability to efficiently clear damaged mitochondria: protective effects of Rapamycin
Immunoregulatory properties of Rapamycin-conditioned monocyte-derived dendritic cells and their role in transplantation
Novel feedback inhibition of surface antigen synthesis by mammalian target of Rapamycin (mTOR) signal and its implication for hepatitis B virus tumorigenesis and …
A Hexane Fraction of Guava Leaves (Psidium guajava L.) Induces Anticancer Activity by Suppressing AKT/Mammalian Target of Rapamycin/Ribosomal p70 S6 …
Clinical activity of mammalian target of Rapamycin inhibitors in solid tumors
A novel application of topical Rapamycin formulation, an inhibitor of mTOR, for patients with hypomelanotic macules in tuberous sclerosis complex
Targeting notch pathway enhances Rapamycin antitumor activity in pancreas cancers through PTEN phosphorylation
Rapamycin ameliorates dystrophic phenotype in mdx mouse skeletal muscle
Mammalian target of Rapamycin expression in poorly differentiated endocrine carcinoma: clinical and therapeutic future challenges
Clinical and histopathologic characteristics of rash in cancer patients treated with mammalian target of Rapamycin inhibitors
Grape polyphenols inhibit Akt/mammalian target of Rapamycin signaling and potentiate the effects of gefitinib in breast cancer
Rapamycin increases the yield and effector function of human γδ T cells stimulated in vitro
Rapamycin combined with TGF-β converts human invariant NKT cells into suppressive Foxp3+ regulatory cells
Effect of dietary choline on growth, intestinal enzyme activities and relative expressions of target of Rapamycin and eIF4E-binding protein2 gene in muscle …
Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of Rapamycin (mTOR)-dependent inhibition of …
Role of mammalian target of Rapamycin in hypoxic or ischemic brain injury: potential neuroprotection and limitations
Spinal phosphinositide 3-Kinase–Akt–Mammalian target of Rapamycin signaling cascades in inflammation-induced hyperalgesia
Enteric-delivered Rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence
Mechanistic or mammalian target of Rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging
Intermittent supplementation with Rapamycin as a dietary restriction mimetic
Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of Rapamycin interaction proteome
The histone H3 lysine 56 acetylation pathway is regulated by target of Rapamycin (TOR) signaling and functions directly in ribosomal RNA biogenesis
TOR: target of Rapamycin
Ksp1 kinase regulates autophagy via the target of Rapamycin complex 1 (TORC1) pathway
Multiple site acetylation of Rictor stimulates mammalian target of Rapamycin complex 2 (mTORC2)-dependent phosphorylation of Akt protein
Clinical outcomes in kidney transplant recipients receiving long‐term therapy with inhibitors of the mammalian target of Rapamycin
Rapamycin preconditioning attenuates transient focal cerebral ischemia/reperfusion injury in mice
… of 32-kDa (DARPP-32)-dependent activation of extracellular signal-regulated kinase (ERK) and mammalian target of Rapamycin complex 1 (mTORC1) …
Mammalian target of Rapamycin and head and neck squamous cell carcinoma
Rapamycin-insensitive mTORC1 activity controls eIF4E: 4E-BP1 binding
Mammalian target of Rapamycin is a therapeutic target for murine ovarian endometrioid adenocarcinomas with dysregulated Wnt/β-catenin and PTEN
Rapamycin suppresses axon sprouting by somatostatin interneurons in a mouse model of temporal lobe epilepsy
Targeting the phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin signaling network in cancer stem cells
Resistin promotes cardiac hypertrophy via the AMP-activated protein kinase/mammalian target of Rapamycin (AMPK/mTOR) and c-Jun N-terminal kinase …
Mechanistic mammalian target of Rapamycin (mTOR) cell signaling: effects of select nutrients and secreted phosphoprotein 1 on development of mammalian …
The mTOR (mammalian target of Rapamycin) kinase maintains integrity of mTOR complex 2
Rapamycin-mediated mTOR inhibition attenuates survivin and sensitizes glioblastoma cells to radiation therapy
Creating diverse target-binding surfaces on FKBP12: synthesis and evaluation of a Rapamycin analogue library
Rapamycin has paradoxical effects on S6 phosphorylation in rats with and without seizures
A retrospective review of oral low-dose sirolimus (Rapamycin) for the treatment of active uveitis
Elimination of proliferating cells unmasks the shift from senescence to quiescence caused by Rapamycin
Drosophila insulin and target of Rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo
Rapamycin treatment inhibits CHO cell death in a serum‐free suspension culture by autophagy induction
Mammalian target of Rapamycin (mTOR) inhibitors slow skin carcinogenesis, but impair wound healing
Rapamycin Reverses Splenomegaly and Inhibits Tumor Development in a Transgenic Model of Epstein-Barr Virus–Related Burkitt’s Lymphoma
A combined approach of classical mutagenesis and rational metabolic engineering improves Rapamycin biosynthesis and provides insights into methylmalonyl-CoA …
The risk of skin rash and stomatitis with the mammalian target of Rapamycin inhibitor temsirolimus: a systematic review of the literature and meta-analysis
Rapamycin reduces oxidative stress in frataxin-deficient yeast cells
Advantage of Rapamycin over mycophenolate mofetil when used with tacrolimus for simultaneous pancreas kidney transplants: randomized, single‐center trial at 10 …
Phosphorylation of Raptor by p38β participates in arsenite-induced mammalian target of Rapamycin complex 1 (mTORC1) activation
Synergistic activity of Rapamycin and dexamethasone in vitro and in vivo in acute lymphoblastic leukemia via cell-cycle arrest and apoptosis
… and a signaling core formed by bifunctional Akt, extracellular signal-regulated kinase (ERK) 1/2, and mammalian target of Rapamycin complex 1 (mTORC1) …
LST8 regulates cell growth via target-of-Rapamycin complex 2 (TORC2)
The mammalian target of Rapamycin pathway is widely activated without PTEN deletion in renal cell carcinoma metastases
Rapamycin induces p53-independent apoptosis through the mitochondrial pathway in non-small cell lung cancer cells
Evaluation of sphingolipid metabolism in renal cortex of rats with streptozotocin-induced diabetes and the effects of Rapamycin
Dissecting mammalian target of Rapamycin to promote longevity
Rapamycin treatment augments both protein ubiquitination and Akt activation in pressure-overloaded rat myocardium
Impact of Rapamycin on peritoneal fibrosis and transport function
Predictive biomarkers for the activity of mammalian target of Rapamycin (mTOR) inhibitors
Rapamycin‐Induced Hypophosphatemia and Insulin Resistance Are Associated With mTORC2 Activation and Klotho Expression
Phospshoinositide 3-kinase (PI3K)/mammalian target of Rapamycin (mTOR) dual inhibitors: discovery and structure–activity relationships of a series of quinoline and …
Emergence of the phosphoinositide 3-kinase-Akt-mammalian target of Rapamycin axis in transforming growth factor-β-induced epithelial-mesenchymal transition
Activation of mammalian target of Rapamycin pathway confers adverse outcome in nonsmall cell lung carcinoma
Dual inhibition of phosphatidylinositol 3‐kinase/Akt and mammalian target of Rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid …
S6 kinase 1 is required for Rapamycin-sensitive liver proliferation after mouse hepatectomy
Metabolic regulation, mitochondria and the life-prolonging effect of Rapamycin: a mini-review
Induction of melanogenesis by Rapamycin in human MNT-1 melanoma cells
Calcineurin inhibitor sparing regimens using m‐target of Rapamycin inhibitors: an opportunity to improve cardiovascular risk following kidney transplantation?
The mammalian target of Rapamycin pathway as a therapeutic target in multiple myeloma
… and its associated cell death by “sphingolipid rheostat”: reciprocal role of ceramide and sphingosine 1-phosphate in the mammalian target of Rapamycin …
Rapamycin sensitive mTOR activation mediates nerve growth factor (NGF) induced cell migration and pro-survival effects against hydrogen peroxide in retinal pigment …
Regulation of the glutamate transporter EAAT3 by mammalian target of Rapamycin mTOR
Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of Rapamycin (mTOR)
The mammalian target of Rapamycin inhibitor RAD001 (everolimus) synergizes with chemotherapeutic agents, ionizing radiation and proteasome inhibitors in …
Stromal liver kinase B1 [STK11] signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian Target of Rapamycin Complex …
NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitors, enhance tumor and endothelial cell …
An elaborate regulation of Mammalian target of Rapamycin activity is required for somatic cell reprogramming induced by defined transcription factors
Rapamycin-induced posterior reversible encephalopathy in a kidney transplantation patient
Mammalian target of Rapamycin pathway activation is associated to RET mutation status in medullary thyroid carcinoma
… secretion via down-regulation of surface expression of adrenergic α2A receptor through the mTOR (mammalian target of Rapamycin) pathway: implication in …
Rapamycin enhances docetaxel-induced cytotoxicity in a androgen-independent prostate cancer xenograft model by survivin downregulation
Beta cell function during Rapamycin monotherapy in long-term type 1 diabetes
Temporal regulation of Rapamycin on memory CTL programming by IL-12
Rapamycin prevents endothelial cell migration by inhibiting the endothelial-to-mesenchymal transition and matrix metalloproteinase-2 and-9: an in vitro study
TGFβ‐and bleomycin‐induced extracellular matrix synthesis is mediated through Akt and mammalian target of Rapamycin (mTOR)
cAMP inhibits mammalian target of Rapamycin complex-1 and-2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity
Enhanced delivery of Rapamycin by V156K-apoA-I high-density lipoprotein inhibits cellular proatherogenic effects and senescence and promotes tissue regeneration
Interpreting mammalian target of Rapamycin and cell growth inhibition in a genetically engineered mouse model of Nf1-deficient astrocytes
First report of a novel abluminal groove filled biodegradable polymer Rapamycin-eluting stent in de novo coronary artery disease: results of the first in man FIREHAWK …
Autophagy induced by Rapamycin and carbon‐starvation have distinct proteome profiles in Aspergillus nidulans
An emerging role for the mammalian target of Rapamycin in “pathological” protein translation: relevance to cocaine addiction
Rapamycin-cyclodextrin complexation: improved solubility and dissolution rate
inhibition of autophagy as a strategy to augment radiosensitization by the dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor NVP-BEZ235
Regulation of mammalian target of Rapamycin and mitogen activated protein kinase pathways by BCR–ABL
mTOR in podocyte function: is Rapamycin good for diabetic nephropathy?
Yin Yang 1 deficiency in skeletal muscle protects against Rapamycin-induced diabetic-like symptoms through activation of insulin/IGF signaling
ULK1, mammalian target of Rapamycin, and mitochondria: linking nutrient availability and autophagy
Mammalian target of Rapamycin mediates the angiogenic effects of leptin in human hepatic stellate cells
Forced degradation studies of Rapamycin: Identification of autoxidation products
Inactivation of mammalian target of Rapamycin (mTOR) by Rapamycin in a murine model of lipopolysaccharide-induced acute lung injury
Pharmacological targeting of mammalian target of Rapamycin inhibits ovarian granulosa cell tumor growth
Innovations therapy: mammalian target of Rapamycin (mTOR) inhibitors for the treatment of neuroendocrine tumors
Nitrogen-responsive regulation of GATA protein family activators Gln3 and Gat1 occurs by two distinct pathways, one inhibited by Rapamycin and the other by …
Myopathy caused by mammalian target of Rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function
Remarkable inhibition of mTOR signaling by the combination of Rapamycin and 1, 4‐phenylenebis (methylene) selenocyanate in human prostate cancer cells
Regulatory T cells expanded by Rapamycin in vitro suppress colitis in an experimental mouse model
Combination of an allosteric Akt Inhibitor MK-2206 with etoposide or Rapamycin enhances the antitumor growth effect in neuroblastoma
Localized ultrasound enhances delivery of Rapamycin from microbubbles to prevent smooth muscle proliferation
inhibition of Akt (ser473) phosphorylation and Rapamycin-resistant cell growth by knockdown of mammalian target of Rapamycin with small interfering RNA in vascular …
Myxoma virus combined with Rapamycin treatment enhances adoptive T cell therapy for murine melanoma brain tumors
Rapamycin and mTORC1 inhibition in the mouse: skin cancer prevention
Rapamycin suppresses ROS-dependent apoptosis caused by selenomethionine in A549 lung carcinoma cells
Curcumin dually inhibits both mammalian target of Rapamycin and nuclear factor-κB pathways through a crossed phosphatidylinositol 3-kinase/Akt/IκB kinase complex …
Longitudinal imaging studies of tumor microenvironment in mice treated with the mTOR inhibitor Rapamycin
Rapamycin regulates bleomycin-induced lung damage in SP-C-deficient mice
Therapeutic efficacy of polyclonal tregs does not require Rapamycin in a low-dose irradiation bone marrow transplantation model
Effects of intermittent and chronic calorie restriction on mammalian target of Rapamycin (mTOR) and IGF-I signaling pathways in mammary fat pad tissues and …
Onychopathy induced by temsirolimus, a mammalian target of Rapamycin inhibitor
… ) ligand 12/chemokine (CXC motif) receptor 4 axis (CXCL12/CXCR4)-mediated cell migration by targeting mammalian target of Rapamycin (mTOR) pathway in …
Modulation of sodium iodide symporter expression and function by LY294002, Akti-1/2 and Rapamycin in thyroid cells
Rapamycin provides a therapeutic option through inhibition of mTOR signaling in chronic myelogenous leukemia
Akt/mammalian target of Rapamycin signaling pathway regulates neurite outgrowth in cerebellar granule neurons stimulated by methylcobalamin
Sorafenib enhances the therapeutic efficacy of Rapamycin in colorectal cancers harboring oncogenic KRAS and PIK3CA
V‐AKT murine thymoma viral oncogene homolog/mammalian target of Rapamycin activation induces a module of metabolic changes contributing to growth in insulin …
Overexpression of the mammalian target of Rapamycin (mTOR) and angioinvasion are poor prognostic factors in early stage NSCLC: a verification study
Unrestrained mammalian target of Rapamycin complexes 1 and 2 increase expression of phosphatase and tensin homolog deleted on chromosome 10 to …
Rapamycin has age‐, treatment paradigm‐, and model‐specific anticonvulsant effects and modulates neuropeptide Y expression in rats
Sorafenib induces apoptotic cell death in human non-small cell lung cancer cells by down-regulating mammalian target of Rapamycin (mTOR)-dependent survivin …
Characterization and targeting of phosphatidylinositol-3 kinase (PI3K) and mammalian target of Rapamycin (mTOR) in renal cell cancer
Ex vivo Rapamycin treatment of human cord blood CD34+ cells enhances their engraftment of NSG mice
Hypoxia‐inducible factor and mammalian target of Rapamycin pathway markers in urothelial carcinoma of the bladder: possible therapeutic implications
Multi-timescale dynamics study of FKBP12 along the Rapamycin–mTOR binding coordinate
Rapamycin: killing two birds with one stone
Immunomodulatory synergy by combining atorvastatin and Rapamycin in the treatment of experimental autoimmune encephalomyelitis (EAE)
Structure–activity relationships of phosphoinositide 3-kinase (PI3K)/mammalian target of Rapamycin (mTOR) dual inhibitors: investigations of various 6, 5-heterocycles …
FLZ protects dopaminergic neuron through activating protein kinase B/mammalian target of Rapamycin pathway and inhibiting RTP801 expression in Parkinson’s …
Uterine histotroph and conceptus development: select nutrients and secreted phosphoprotein 1 affect mechanistic target of Rapamycin cell signaling in ewes
MicroRNA-100 regulates neovascularization by suppression of mammalian target of Rapamycin in endothelial and vascular smooth muscle cells
Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from Rapamycin
Rapamycin inhibits formation of urethral stricture in rabbits
Rapamycin down-regulates KCC2 expression and increases seizure susceptibility to convulsants in immature rats
Rapamycin inhibits the proliferation and apoptosis of gastric cancer cells by down regulating the expression of survivin.
Topical Rapamycin suppresses the angiogenesis pathways induced by pulsed dye laser: molecular mechanisms of inhibition of regeneration and revascularization of …
Early use of mammalian target of Rapamycin inhibitors is an independent risk factor for incisional hernia development after liver transplantation
… )phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a Potent, Selective, and Orally Available Mammalian Target of Rapamycin (mTOR) Inhibitor for Treatment of …
Comparative efficacy of vascular endothelial growth factor (VEGF) tyrosine kinase inhibitor (TKI) and mammalian target of Rapamycin (mTOR) inhibitor as second-line …
Combined inhibition of PI3K and mTOR exerts synergistic antiproliferative effect, but diminishes differentiative properties of Rapamycin in acute myeloid leukemia cells
Rapamycin as longevity enhancer and cancer preventative agent in the context of p53 deficiency
Effects of STAT3 gene silencing and Rapamycin on apoptosis in hepatocarcinoma cells
Mammalian target of Rapamycin as a target in hematological malignancies
… ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of Rapamycin complex 1), FOXM1 …
Osmotic stress regulates mammalian target of Rapamycin (mTOR) complex 1 via c-Jun N-terminal Kinase (JNK)-mediated Raptor protein phosphorylation
Rapamycin-loaded nanoparticles for inhibition of neointimal hyperplasia in experimental vein grafts
Activation of the phosphoinositide‐3‐kinase and mammalian target of Rapamycin signaling pathways are associated with shortened survival in patients with malignant …
Rictor-dependent AKT activation and inhibition of urothelial carcinoma by Rapamycin
Src kinase activity coordinates cell adhesion and spreading with activation of mammalian target of Rapamycin in pancreatic endocrine tumour cells
Rapamycin inhibits osteoclast formation in giant cell tumor of bone through the C/EBPβ-MafB axis
Insulin‐like growth factor I regulates G2/M progression through mammalian target of Rapamycin signaling in oligodendrocyte progenitors
… method validation of Rapamycin in ocular matrix by QTRAP LC–MS/MS: Application to rabbit anterior tissue distribution by topical administration of Rapamycin …
Target of Rapamycin complex 2 signals to downstream effector yeast protein kinase 2 (Ypk2) through adheres-voraciously-to-target-of-Rapamycin-2 protein 1 …
Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of Rapamycin as a therapeutic strategy for acute leukemia …
Mammalian target of Rapamycin signal inhibitors could play a role in the treatment of BK polyomavirus nephritis in renal allograft recipients
A Burkholderia pseudomallei macrophage infectivity potentiator-like protein has Rapamycin-inhibitable peptidylprolyl isomerase activity and pleiotropic effects on …
Multifaceted role of insulin-like growth factors and mammalian target of Rapamycin in skeletal muscle
Local delivery of Rapamycin: a toxicity and efficacy study in an experimental malignant glioma model in rats
Rapamycin enhances the activity of oncolytic herpes simplex virus against tumor cells that are resistant to virus replication
… -mediated activation of phospholipase D and mammalian target of Rapamycin (mTOR) regulates proliferation and Rapamycin sensitivity of hepatocarcinoma …
Blocking mTORC1 activity by Rapamycin leads to impairment of spatial memory retrieval but not acquisition in C57BL/6J mice
Phosphatidylinositol 3-kinase/AKT/mammalian target of Rapamycin pathway inhibition: a breakthrough in the management of luminal (ER+/HER2−) breast cancers?
Sorafenib, a multikinase inhibitor, is effective in vitro against non‐hodgkin lymphoma and synergizes with the mTOR inhibitor Rapamycin
Mammalian target of Rapamycin signaling pathway contributes to glioma progression and patients’ prognosis
The mTOR-inhibitor Rapamycin mediates proteinuria in nephrotoxic serum nephritis by activating the innate immune response
… molecular approach to the PI3K/AKT/mTOR (phosphoinositide 3‐kinase/v‐akt murine thymoma viral oncogene/mammalian target of Rapamycin) pathway in bladder …
Rapamycin combined with anti-CD45RB mAb and IL-10 or with G-CSF induces tolerance in a stringent mouse model of islet transplantation
The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of Rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 …
Phosphorylated mammalian target of Rapamycin expression is associated with the response to chemoradiotherapy in patients with esophageal squamous cell …
IL-33 induces innate lymphoid cell–mediated airway inflammation by activating mammalian target of Rapamycin
… recognition memory consolidation involves activation of the extracellular signal-regulated kinase (ERK) and mammalian target of Rapamycin (mTOR) pathways in the …
Improved insulin sensitivity by Rapamycin is associated with reduction of mTOR and S6K1 activities in L6 myotubes
Rheb/mTOR activation and regulation in cancer: novel treatment strategies beyond Rapamycin
Threonine-120 phosphorylation regulated by phosphoinositide-3-kinase/Akt and mammalian target of Rapamycin pathway signaling limits the antitumor …
Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with Rapamycin, an mTOR inhibitor and anti-aging drug
Dual targeting of phosphoinositide 3-kinase and mammalian target of Rapamycin using NVP-BEZ235 as a novel therapeutic approach in human ovarian carcinoma
Topical 0.1% Rapamycin for angiofibromas in paediatric patients with tuberous sclerosis: a pilot study of four patients
Rapamycin inhibits hydrogen peroxide-induced loss of vascular contractility
Rapamycin sensitive ROS formation and Na+/H+ exchanger activity in dendritic cells
Rheb, an activator of target of Rapamycin, in the blackback land crab, Gecarcinus lateralis: cloning and effects of molting and unweighting on expression in skeletal …
Tramadol pretreatment enhances ketamine-induced antidepressant effects and increases mammalian target of Rapamycin in rat hippocampus and prefrontal …
Phosphatidylinositol 3, 5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of Rapamycin 1
Novel withanolides target medullary thyroid cancer through inhibition of both RET phosphorylation and the mammalian target of Rapamycin pathway
Regulation of mammalian target of Rapamycin complex 1 (mTORC1) by hypoxia: causes and consequences
Non-clear cell renal cell carcinoma: does the mammalian target of Rapamycin represent a rational therapeutic target?
Rapamycin decreases airway remodeling and hyperreactivity in a transgenic model of noninflammatory lung disease
Mammalian target of Rapamycin inhibition in polycystic kidney disease: From bench to bedside
Rapamycin suppresses the recurrent excitatory circuits of dentate gyrus in a mouse model of temporal lobe epilepsy
Relief with Rapamycin: mTOR inhibition protects against radiation-induced mucositis
Rapamycin potentiates cytotoxicity by docetaxel possibly through downregulation of Survivin in lung cancer cells
Targeting the JNK signaling pathway potentiates the antiproliferative efficacy of Rapamycin in LS174T colon cancer cells
Rapamycin decreases survivin expression to induce NSCLC cell apoptosis under hypoxia through inhibiting HIF-1α induction
Controlled release formulations of IL-2, TGF-β1 and Rapamycin for the induction of regulatory T cells
Differential regulation of the p73 cistrome by mammalian target of Rapamycin reveals transcriptional programs of mesenchymal differentiation and tumorigenesis
Rapamycin (sirolimus) protects against hypoxic damage in primary heart cultures via Na+/Ca2+ exchanger activation
Surface crystallization of Rapamycin on stents using a temperature induced process
Preclinical assessment of the absorption and disposition of the phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor GDC-0980 and prediction of its …
Rapamycin impairs UV induction of mutant‐p53 overexpressing cell clusters without affecting tumor onset
Chemoprevention of age-related macular regeneration (AMD) with Rapamycin
FOXO3a reactivation mediates the synergistic cytotoxic effects of Rapamycin and cisplatin in oral squamous cell carcinoma cells
Cooperative benefit for the combination of Rapamycin and imatinib in tuberous sclerosis complex neoplasia
Rapamycin‐sensitive signals control TCR/CD28‐driven Ifng, Il4 and Foxp3 transcription and promoter region methylation
Topical use of Rapamycin in herpetic stromal keratitis
Flt3L combined with Rapamycin promotes cardiac allograft tolerance by inducing regulatory dendritic cells and allograft autophagy in mice
Rho-associated kinase connects a cell cycle-controlling anchorage signal to the mammalian target of Rapamycin pathway
Rapamycin induces the anti-apoptotic protein survivin in neuroblastoma
Transcript abundance of hormone receptors, mammalian target of Rapamycin pathway-related kinases, insulin-like growth factor I, and milk proteins in porcine …
Mammalian target of Rapamycin regulates expression of β-catenin in hepatocellular carcinoma
Everolimus: a new mammalian target of Rapamycin inhibitor for the treatment of advanced renal cell carcinoma
Rapamycin prevents the mutant huntingtin-suppressed GLT-1 expression in cultured astrocytes
mTORC1 activity as a determinant of cancer risk–rationalizing the cancer-preventive effects of adiponectin, metformin, Rapamycin, and low-protein vegan diets
Efficacy of ganitumab (AMG 479), alone and in combination with Rapamycin, in Ewing’s and osteogenic sarcoma models
Potent, selective, and orally bioavailable inhibitors of the mammalian target of Rapamycin kinase domain exhibiting single agent antiproliferative activity
NOTCH and phosphatidylinositide 3-kinase/phosphatase and tensin homolog deleted on chromosome ten/AKT/mammalian target of Rapamycin (mTOR) signaling in T …
The E3 ubiquitin ligase protein associated with Myc (Pam) regulates mammalian/mechanistic target of Rapamycin complex 1 (mTORC1) signaling in vivo …
Mammalian target of Rapamycin complex 2 regulates inflammatory response to stress
Sindbis virus replication, is insensitive to Rapamycin and torin1, and suppresses Akt/mTOR pathway late during infection in HEK cells
Potent, selective, and orally bioavailable inhibitors of mammalian target of Rapamycin (mTOR) kinase based on a quaternary substituted dihydrofuropyrimidine
Rapamycin combined with allogenic immature dendritic cells selectively expands CD4+ CD25+ Foxp3+ regulatory T cells in rats
Identification of mammalian target of Rapamycin as a direct target of fenretinide both in vitro and in vivo
Positively charged amphiphilic chitosan derivative for the transscleral delivery of Rapamycin
Growth hormone improves growth retardation induced by Rapamycin without blocking its antiproliferative and antiangiogenic effects on rat growth plate
New developments in mammalian target of Rapamycin inhibitors for the treatment of sarcoma
Temsirolimus in advanced leiomyosarcomas: patterns of response and correlation with the activation of the mammalian target of Rapamycin pathway
Mammalian target of Rapamycin (mTOR) inhibition reduces cerebral vasospasm following a subarachnoid hemorrhage injury in canines
Rapamycin affects tissue plasminogen activator and plasminogen activator inhibitor 1 expression: a potential prothrombotic mechanism of drug-eluting stents
Rapamycin inhibits the invasive ability of thyroid cancer cells by down‐regulating the expression of VEGF‐C in vitro
Antileukaemia effect of Rapamycin alone or in combination with daunorubicin on Ph+ acute lymphoblastic leukaemia cell line
5′-Adenosine monophosphate-activated protein kinase–mammalian target of Rapamycin axis as therapeutic target for age-related macular degeneration
Toxicity spectrum of inhibitors of mammalian target of Rapamycin in organ transplantation: etiology, pathogenesis and treatment
Nuclear factor of activated T-cell c3 inhibition of mammalian target of Rapamycin signaling through induction of regulated in development and DNA damage response …
inhibition of mammalian target of Rapamycin: two goals with one shot?
The FKBP–Rapamycin binding domain of human TOR undergoes strong conformational changes in the presence of membrane mimetics with and without the regulator …
Combination testing (Stage 2) of the Anti‐IGF‐1 receptor antibody IMC‐A12 with Rapamycin by the pediatric preclinical testing program
Rapamycin inhibits lipopolysaccharide induction of granulocyte‐colony stimulating factor and inducible nitric oxide synthase expression in macrophages by reducing …
… study of 3-in-1 poly (ethylene glycol)-block-poly (D, L-lactic acid) micelles carrying paclitaxel, 17-allylamino-17-demethoxygeldanamycin, and Rapamycin
Intranuclear function for protein phosphatase 2A: Pph21 and Pph22 are required for Rapamycin-induced GATA factor binding to the DAL5 promoter in yeast
mTORC1/2 and Rapamycin in female Han: SPRD rats with polycystic kidney disease
Mammalian target of Rapamycin (mTOR) phosphorylates inositol 1, 4, 5-trisphosphate receptor type 2 and increases its Ca2+ release activity
inhibition of Mammalian target of Rapamycin in human acute myeloid leukemia cells has diverse effects that depend on the environmental in vitro stress
Evaluation of an AAV2-based Rapamycin-regulated glial cell line-derived neurotrophic factor (GDNF) expression vector system
Target of Rapamycin (TOR) controls vitellogenesis via activation of the S6 kinase in the fat body of the tick, Haemaphysalis longicornis
Effect of complementary pathway blockade on efficacy of combination enzastaurin and Rapamycin
The expression of URGCP gene in prostate cancer cell lines: correlation with Rapamycin
Targeting the autophagy pathway using ectopic expression of Beclin 1 in combination with Rapamycin in drug-resistant v-Ha-ras-transformed NIH 3T3 cells
Targeting glycolysis in leukemia: a novel inhibitor 3-BrOP in combination with Rapamycin
Local application of Rapamycin inhibits vein graft restenosis in rabbits
Drosophila larvae lacking the bcl-2 gene, buffy, are sensitive to nutrient stress, maintain increased basal target of Rapamycin (Tor) signaling and exhibit …
… proteolysis system by amino acids and insulin involves the adenosine monophosphate-activated protein kinase and mammalian target of Rapamycin pathways in rat …
Targeted inhibition of mammalian target of Rapamycin (mTOR) signaling pathway inhibits proliferation and induces apoptosis of laryngeal carcinoma cells in vitro
Rapamycin induces differentiation of glioma stem/progenitor cells by activating autophagy
Pharmacologic synergy between dual phosphoinositide-3-kinase and mammalian target of Rapamycin inhibition and 5-Fluorouracil in PIK3CA mutant gastric cancer …
Rapamycin: A rheostat for CD8+ T-cell-mediated tumor therapy
Intranasal Rapamycin rescues mice from staphylococcal enterotoxin B-induced shock
A double whammy for aging? Rapamycin extends lifespan and inhibits cancer in inbred female mice
Aberrant expression of the mammalian target of Rapamycin, hypoxia-inducible factor-1α, and glucose transporter 1 in the development of ovarian clear-cell …
Effects of FTY720 and Rapamycin on inflammation in taurocholate-induced acute pancreatitis in the rat
A novel method for the elution of sirolimus (Rapamycin) in drug-elution stents
Krüppel‐like factor 4 is induced by Rapamycin and mediates the anti‐proliferative effect of Rapamycin in rat carotid arteries after balloon injury
Adiponectin inhibits PDGF-induced mesangial cell proliferation: regulation of mammalian target of Rapamycin-mediated survival pathway by adenosine 5 …
Rapamycin enhances dimethyl sulfoxide-mediated growth arrest in human myelogenous leukemia cells
Regulation of karyopherin α1 and nuclear import by mammalian target of Rapamycin
Nuclear PIM1 confers resistance to Rapamycin-impaired endothelial proliferation
Rapamycin-induced impaired wound healing is associated with compromised tissue lactate accumulation and extracellular matrix remodeling
Mechanism of activation of AMPK and upregulation of OGG1 by Rapamycin in cancer cells
The translational response of the human mdm2 gene in HEK293T cells exposed to Rapamycin: a role for the 5′-UTRs
Hepatocyte growth factor-induced c-Src-phosphatidylinositol 3-kinase-AKT-mammalian target of Rapamycin pathway inhibits dendritic cell activation by blocking IκB …
Combination of ATP-competitive mammalian target of Rapamycin inhibitors with standard chemotherapy for colorectal cancer
Antitumor efficacy of mammalian target of Rapamycin inhibitor therapy in liver transplant recipients with oncological disease: a case-control study
The mammalian Target of Rapamycin (mTOR) regulates T helper cell differentiation through the selective activation of mTORC1 and mTORC2 signaling
Effects of Rapamycin on expression of Bcl-2 and Bax in human lens epithelial cells and cell cycle in rats
Rapamycin treatment causes developmental delay, pigmentation defects, and gastrointestinal malformation on Xenopus embryogenesis
Systemic Rapamycin alone may not be a treatment option for malignant glioma: evidence from an in vivo study
Cardiovascular risk in kidney transplant recipients receiving mammalian target of Rapamycin inhibitors
Morphoproteomics demonstrates activation of mammalian target of Rapamycin pathway in papillary thyroid carcinomas with nuclear translocation of mTOR in …
Effect of combination of Rapamycin and cisplatin on human cervical carcinoma Hela cells
Indications and effectiveness of the mammalian target of Rapamycin in liver transplantation
Rapamycin prevents interstitial fibrosis in renal allografts through decreasing angiogenesis and inflammation
Rapamycin induced ultrastructural and molecular alterations in glomerular podocytes in healthy mice
Conversion to low-dose tacrolimus or Rapamycin 3 months after kidney transplantation: a prospective, protocol biopsy-guided study
Rapamycin‐mediated suppression of renal cyst expansion in del34 Pkd1−/− mutant mouse embryos: An investigation of the feasibility of renal cyst prevention in the …
Rapamycin-conditioned, alloantigen-pulsed myeloid dendritic cells present donor MHC class I/peptide via the semi-direct pathway and inhibit survival of antigen …
Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by Rapamycin
Combined targeting of the VEGFr/EGFr and the mammalian target of Rapamycin (mTOR) signaling pathway delays cell cycle progression and alters adhesion behavior …
One‐year clinical outcome of a randomized trial of polymer‐free paclitaxel‐eluting stents versus biodegradable polymer‐based Rapamycin‐eluting stents in patients …
Chronic hypoxia impairs murine hippocampal development and depletes the postnatal progenitor pool by attenuating mammalian target of Rapamycin …
inhibition of mammalian target of Rapamycin signaling by everolimus induces senescence in adult T‐cell leukemia/lymphoma and apoptosis in peripheral T‐cell …
The inhibitory effect of Rapamycin on the oval cell response and development of preneoplastic foci in the rat
Insulin-induced neurite-like process outgrowth: acceleration of tau protein synthesis via a phosphoinositide 3-kinase∼ mammalian target of Rapamycin pathway
Rapamycin for life: a step to immortality
Target of Rapamycin (TOR)–Based Therapy for Cardiomyopathy: Evidence From Zebrafish and Human Studies
Rapamycin as immunosuppressant in murine transplantation model
Effect of feeding a high-protein diet following an 18-hour period of feed withholding on mammalian target of Rapamycin-dependent signaling in skeletal muscle of …
Destabilization of TNF-α mRNA by Rapamycin
Rapamycin-based inducible translocation systems for studying phagocytosis
Immunoexpression status and prognostic value of mammalian target of Rapamycin and hypoxia-induced pathway members in papillary cell renal cell carcinomas
Targeting the dysregulated mammalian target of Rapamycin pathway in organ transplantation: killing 2 birds with 1 stone
Rapamycin and 3-methyladenine regulate apoptosis and autophagy in bone-derived endothelial progenitor cells
Expression of the mammalian target of Rapamycin pathway markers in lung adenocarcinoma and squamous cell carcinoma
… and effectiveness of oral Rapamycin plus bare‐metal stents with drug‐eluting stents: Three‐year outcome from the randomized oral Rapamycin in Argentina (ORAR) III …
Mammalian target of Rapamycin expression and laryngeal squamous cell carcinoma prognosis: novel preliminary evidence
Chronic inhibition of mTOR by Rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice
Poly (ethylene glycol)-block-poly (2-methyl-2-benzoxycarbonyl-propylene carbonate) micelles for Rapamycin delivery: in vitro characterization and biodistribution
Differential modulation of the cytokine-induced MMP-9/TIMP-1 protease–antiprotease system by the mTOR inhibitor Rapamycin
Enhanced sensitivity to Rapamycin following long-term oestrogen deprivation in MCF-7, T-47-D and ZR-75-1 human breast cancer cells
Selective ATP-Competitive Inhibitors of TOR Suppress Rapamycin-Insensitive Function of TORC2 in Saccharomyces cerevisiae
Differential Regulation of Simultaneous Antitumor and Alloreactive CD8+ T‐Cell Responses in the Same Host by Rapamycin
Mammalian Target of Rapamycin inhibition in Macrophages of Asymptomatic HIV+ Persons Reverses the Decrease in TLR-4–Mediated TNF-α Release through …
Gene expression profile in response to doxorubicin–Rapamycin combined treatment of HER-2–overexpressing human mammary epithelial cell lines
… tumour necrosis factor (TNF)‐α‐induced apoptosis through eukaryotic translation initiation factor 2α (eIF2α)‐and mammalian target of Rapamycin complex 1 (mTORC1 …
Rapamycin combined with donor immature dendritic cells promotes liver allograft survival in association with CD4+CD25+Foxp3+ regulatory T cell expansion
Activation of mammalian target of Rapamycin in diffuse large B-cell lymphoma: a clinicopathological study
Rapamycin regulates the expression and activity of krüppel-like transcription factor 2 in human umbilical vein endothelial cells
Advanced retinoblastoma treatment: targeting hypoxia by inhibition of the mammalian target of Rapamycin (mTOR) in LHBetaTag retinal tumors
Abstract CT-02: A phase I, open label, dose escalation study of oral mammalian target of Rapamycin inhibitor INK128 administered by intermittent dosing regimens in …
Characterization of Foxp3 gene from grass carp (Ctenopharyngodon idellus): a Rapamycin-inducible transcription factor in teleost immune system
RETRACTED: Enhanced cellular uptake and in vivo pharmacokinetics of Rapamycin loaded cubic phase nanoparticles for cancer therapy
Bevacizumab and Rapamycin can decrease corneal opacity and apoptotic keratocyte number following photorefractive keratectomy
Are we ready to move away from nature? The Rapamycin story
… renal angiomyolipomas and lymphangioleiomyomatosis presenting after two successive pregnancies successfully treated with surgery and Rapamycin
Biochemical and pharmacological inhibition of mTOR by Rapamycin and an ATP-competitive mTOR inhibitor
Rapamycin conditioning of dendritic cells differentiated from human ES cells promotes a tolerogenic phenotype
Rapamycin selectively alters serum chemistry in diabetic mice
Andes virus infection of lymphatic endothelial cells causes giant cell and enhanced permeability responses that are Rapamycin and vascular endothelial growth factor …
The combination of the novel glycolysis inhibitor 3-BrOP and Rapamycin is effective against neuroblastoma
… Akt hyperphosphorylation and an oxidative stress-mediated cell death in serum starved SK-N-SH human neuroblastoma cells that are augmented by Rapamycin
Use of factorial design for evaluation of factors affecting the chemical stability of sirolimus (Rapamycin) in solid dosage form.
Drosophila poly suggests a novel role for the Elongator complex in insulin receptor–target of Rapamycin signalling
… ribosome entry site-transacting factor (ITAF) function via effects on strand annealing and results in mammalian target of Rapamycin complex 1 (mTORC1) …
Immunohistochemical evidence of dysregulation of the mammalian target of Rapamycin pathway in primary and metastatic pheochromocytomas
Effect of Rapamycin on high glucose-induced autophagy impairment, oxidative stress and premature senescence in rat mesangial cells in vitro
A role of the mammalian target of Rapamycin (mTOR) in glutamate-induced down-regulation of tuberous sclerosis complex proteins 2 (TSC2)
Role of Rapamycin‐Induced Autophagy in Pancreatic Islets
Rapamycin Generates Graft-Homing Murine Suppressor CD8+ T Cells That Confer Donor-Specific Graft Protection
Positive regulation of inositol 1,4,5‐trisphosphate‐induced ca2+ release by mammalian target of Rapamycin (mTOR) in RINm5F cells
inhibition by Rapamycin of the lipoteichoic acid-induced granulocyte-colony stimulating factor expression in mouse macrophages
Markers for efficacy of mammalian target of Rapamycin inhibitor
Immunosuppressive drug Rapamycin restores sporulation competence in industrial yeasts
Immunosuppression in kidney donors with Rapamycin and tacrolimus. Proinflammatory cytokine expression
… stents to bare-metal stents in patients with ST-segment elevation myocardial infarction: an analysis of the RESEARCH (Rapamycin-eluting stent evaluated at …
Mechanisms mediating the cardioprotective effects of Rapamycin in ischaemia–reperfusion injury
Rapamycin inhibition of baculovirus recombinant (BVr) ribosomal protein S6 kinase (S6K1) is mediated by an event other than phosphorylation
A phase I, open label, dose escalation study of an oral mammalian target of Rapamycin inhibitor INK128 administered once daily in patients with advanced …
Mammalian target of Rapamycin inhibitors for treatment in tuberous sclerosis
Prognostic markers in renal cell carcinoma: A focus on the ‘mammalian target of Rapamycin‘pathway
Is proteinuria reversible, after withdrawal of mammalian target of Rapamycin inhibitors?
Rapamycin induces heme oxygenase-1 in liver but inhibits bile flow recovery after ischemia
Enhanced Rapamycin production in Streptomyces hygroscopicus by integrative expression of aveR, a LAL family transcriptional regulator
Expansion of CD4+ CD25+ regulatory T cells from cord blood CD4+ cells using the common γ-chain cytokines (IL-2 and IL-15) and Rapamycin
The phosphoinositide 3-kinase/mammalian target of Rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy
Everolimus vs. Rapamycin for treating diabetic nephropathy in diabetic mouse model
RNA polymerase II degradation in response to Rapamycin is not mediated through ubiquitylation
Akt (protein kinase B) isoform phosphorylation and signaling downstream of mTOR (mammalian target of Rapamycin) in denervated atrophic and hypertrophic …
… of three enzymes for fatty acid synthesis into mouse milk in association with fat globules, and rapid decrease of the secreted enzymes by treatment with Rapamycin
inhibition of mTORC1 kinase activates Smads 1 and 5 but not Smad8 in human prostate cancer cells, mediating cytostatic response to Rapamycin
Comparative assessment of mammalian target of Rapamycin inhibitor‐eluting stents in the treatment of coronary artery bifurcation lesions: The CASTOR‐Bifurcation …
Multimodal biomarker investigation on efficacy and mechanism of action for the mammalian target of Rapamycin inhibitor, temsirolimus, in a preclinical mammary …
Rapamycin inhibiting Jurkat T cells viability through changing mRNA expression of serine/threonine protein phosphatase 2A
Multispecies-compatible antitumor effects of a cross-species small-interfering RNA against mammalian target of Rapamycin
The target of Rapamycin: structure and functions
Artemisinin and Rapamycin compromise nitric oxide-driven and hypoxia-triggered acute articular synovitis in mice
Multimodal imaging of growth and Rapamycin-induced regression of colonic adenomas in APC mutation-dependent mouse
Forever young? Exploring the link between Rapamycin, longevity and cancer
Identification of novel Rapamycin derivatives as low-level impurities in active pharmaceutical ingredients
Deoxyribose protects against Rapamycin-induced cytotoxicity in colorectal cancer cells in vitro
Rapamycin-induced tumor vasculature remodeling in rhabdomyosarcoma xenografts increases the effectiveness of adjuvant ionizing radiation
Mammalian target of Rapamycin inhibitors in organ transplantation: an unkept promise
Study on the rat intestinal absorption of Rapamycin formulated in self-microemulsifying drug delivery system by single-pass intestinal perfusion technique [J]
Synergistic cytotoxic effects of Rapamycin and idarubicin on human acute T-cell lymphoblastic leukemia Jurkat cells
Impact of pyrrolidine dithiocarbamate and interleukin-6 on mammalian target of Rapamycin complex 1 regulation and global protein translation
Molecular characterization and functional analysis of Cashmere goat mammalian target of Rapamycin
Tumor growth effects of Rapamycin on human biliary tract cancer cells
Decrease in transient receptor potential melastatin 6 mRNA stability caused by Rapamycin in renal tubular epithelial cells
Rapamycin and a hyaluronic acid-carboxymethylcellulose membrane did not lead to reduced adhesion formations in a rat abdominal adhesion model
inhibition of mammalian target of Rapamycin signaling by CCI-779 (Temsirolimus) induces growth inhibition and cell cycle arrest in Cashmere goat fetal fibroblasts …
Cost-effectiveness analysis of the early conversion of tacrolimus to mammalian target of Rapamycin inhibitors in patients with renal transplantation
Ex vivo transfer of adenovirus-mediated CTLA4Ig gene combined with a short course of Rapamycin therapy prolongs free flap allograft survival
From node to pathway blockade: lessons learned from targeting mammalian target of Rapamycin.
A study about drug combination therapy of Schisandra sphenanthera extract and Rapamycin in healthy subjects
Nonobese diabetic natural killer cells: a barrier to allogeneic chimerism that can be reduced by Rapamycin
Rapamycin synergizes with low dose oxaliplatin in the HCT116 colon cancer cell line by inducing enhanced apoptosis
Metabolic function of a suboptimal transplanted islet mass in nonhuman primates on Rapamycin monotherapy
Switching from calcineurin inhibitors to mammalian target of Rapamycin inhibitors—finally caught the right wave?
The phosphatidylinositol 3′ kinase-Akt-mammalian target of Rapamycin pathway in smooth muscle tumors of the uterus: selected protein expression patterns and …
Targeted therapy in sarcomas: mammalian target of Rapamycin inhibitors from bench to bedside
REDV/Peptide conjugated Rapamycin-loaded polymer matrix for endothelial cells selectivity
Rapamycin protects against dominant negative-HNF1A-induced apoptosis in INS-1 cells
A simple and efficient route to the FKBP-binding domain from Rapamycin
Functional analysis of the single Est1/Ebs1 homologue in Kluyveromyces lactis reveals roles in both telomere maintenance and Rapamycin resistance
Linking molecular feature space and disease terms for the immunosuppressive drug Rapamycin
Effect of Rapamycin on immunity induced by vector-mediated dystrophin expression in mdx skeletal muscle
Modified Rapamycin targets PKD
Prevalence and clinical significance of mammalian target of Rapamycin phosphorylation (p-mTOR) and vascular endothelial growth factor (VEGF) in clear cell …
Gastric mammalian target of Rapamycin signaling, hormone production and energy metabolism
Rapamycin in lipoproteins for enhanced delivery
Combined use of Rapamycin and leflunomide in prevention of acute cardiac allografts rejection in rats
Effect of nab-Rapamycin versus Rapamycin in colorectal cancer cell lines and associations with KRAS and PI3K mutations.
Improvement of Rapamycin fermentation with culture condition optimization and rational strain breeding
Meta-analysis of immunosuppressive therapy with target-of-Rapamycin inhibitor instead of calcineurin inhibitor after kidney transplantation operation
The isomerase Rrd1 mediates rapid loss of the Sgs1 helicase in response to Rapamycin
Mammalian Target of Rapamycin
Long-Term Maintenance Therapy for Post–Cardiac Transplant Monoclonal Lymphoproliferative Disorder: Caveat Mammalian Target of Rapamycin
Rapamycin effect on senescence and autophagy processes in human cell lines
Targeting the phosphatidylinosital 3-kinase, Akt, and mammalian target of Rapamycin pathway in non-small cell lung cancer
… microenvironment, induces apoptosis, and enhances the antitumor activity of everolimus (RAD001), an inhibitor of mammalian target of Rapamycin (mTOR), in mantle …
Rapamycin inhibits the proliferation of prostate cancer cell line 22RV1 and activity of S6K1
Amphiphilic chitosan nanomicelles for the topical delivery of Rapamycin
Effect of Rapamycin combined with cisplatin on head and neck squamous cancer cells regulated by CCL19
Phosphatidykinosital 3-Kinase and Mammalian Target of Rapamycin Pathway in Non–Small-Cell Lung Cancer
Chemosensitivity enhancement of Rapamycin on hepatocellular carcinoma and related mechanism
Progress of Rapamycin and its derivatives in anti-tumor activity [J]
40‐O ‐[2‐Hydroxyethyl]Rapamycin modulates human dendritic cell function during exposure to Aspergillus fumigatus
A phase I trial of escalating dose of the Rapamycin analog everolimus in combination with the kinase inhibitor midostaurin in patients (pts) with relapsed, refractory or …
Rapamycin impacts positively on longevity, despite glucose intolerance induction
Treatment of pulmonary and retroperitoneal lymphangioleiomyomatosis with Rapamycin: a case presentation and literature review
Glycogen synthase kinase (GSK)-3 and mammalian target of Rapamycin complex 1 (mTORC1) cooperate to regulate protein S6 kinase 1 (S6K1)
Constitutive activation of mTOR pathway by leucine causes heart hypertrophy which can be blocked by Rapamycin
Rapamycin inhibits IL-33-induced airway inflammation
Preclinical efficacy of AZD8055, an ATP-competitive mammalian target of Rapamycin (mTOR) kinase inhibitor, in vitro in clear cell renal cell carcinoma (RCC)
Effects of Rapamycin and tacrolimus on mature endothelial cells and endothelial progenitor cells
An investigation of reversal of imatinib resistance in the Bcr‐Abl positive imatinib‐resistant cell line K562r by dasatinib, nilotinib, Rapamycin and bortezomib
Frequent activation of mammalian target of Rapamycin in primary lung adenocarcinoma and preinvasive lesion
Role of Rapamycin in cholangiocytes regeneration after liver transplantation
Activation of PI3K/AKT and MAPK pathway through a PDGFRb-dependent feedback loop is involved in Rapamycin resistance in hepatocellular carcinoma
Retraction: Rapamycin-loaded nanoparticles for inhibition of neointimal hyperplasia in experimental vein grafts
The Regulation of Mammalian Target of Rapamycin
Dual inhibition of Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin: a Therapeutic Strategy for Acute Leukemias.
BI 836845, a fully human IGF ligand neutralizing antibody, to improve the efficacy of Rapamycin by blocking Rapamycin-induced AKT activation.
Mammalian target of Rapamycin (mTOR) sigaling pathway involved in the inhibition of silence information regulator1 (Sirt1) on fat deposition of mice.
Mdx mice have a defect in autophagy that is restored by Rapamycin‐loaded nanoparticle treatment
Dissecting Rapamycin Responses
Pretreatment of isolated vein with Rapamycin nanoparticles inhibits vein graft stenosis in rabbits
Comment on “Stability of human Rapamycin-expanded CD4+ CD25+ T regulatory cells” Haematologica 2011; 96 (9): 1357–65
Expression of mammalian target of Rapamycin in colon cancer and its effect on proliferation and apoptosis of human colon cancer HT-29 cells
Oral Rapamycin does not mimic caloric restriction in mice
A Burkholderia pseudomallei Mip-like protein has Rapamycin inhibitable peptidyl-prolyl isomerase activity and has pleiotropic effects on virulence
Effects of Rapamycin on glucose metabolism and insulin resistance in obese mice [J]
Effects of Rapamycin on growth and proliferation of human non-small cell lung cancer cell line A549
A synthetic lethality combination with chloroquine and Rapamycin on chemosensitization
Preparation and Release Behavior of Rapamycin-Loaded Micelles [J]
OChiPEG micelles proven to facilitate the transscleral delivery of Rapamycin
Discovery and Optimization of a Series of Benzothiazole Phosphoinositide 3-kinase (PI3K)/mammalian Target of Rapamycin (mTOR) Dual Inhibitors
Effects of Rapamycin on Dia2 Localization
Rapamycin-mediated interaction of spleen γδT lymphocytes and lung macrophages in acute lung injury of mice induced by lipopolysaccharide
Anti-aging gene klotho deficiency causes hypertension and vascular dysfunction via upregulation of mammalian target of Rapamycin (mTOR)
Metformin and Rapamycin inhibit proliferation and alter glucose metabolism in endometrial and ovarian cancer cell lines
Acquired Omenn-Like Syndrome, a Novel Posttransplant Autoaggression Syndrome Reversed by Rapamycin
Rapamycin augments the NMDA-mediated TNF suppression of MRSA-stimulated RAW264. 7 murine macrophages
Promising Activity of Mammalian Target of Rapamycin Inhibitors in Hematologic Malignancies Therapy
Rapamycin Relieves ER Stress and Improves Function in Hearts Subjected to High Workload
Mammalian Target of Rapamycin (mTOR) inhibition: Potential for Antiseizure, Antiepileptogenic, and Epileptostatic Therapy
Mechanistic target of Rapamycin small interfering RNA and Rapamycin synergistically inhibit tumour growth in a mouse xenograft model of human oesophageal …
The antitumor effect of GDC-0941 alone and in combination with Rapamycin in breast cancer cells
inhibition of TGF-β1-induced extracellular matrix production in primary human pulmonary fibroblasts by Rapamycin
Effects of combination treatment of Rapamycin and adriamycin on proliferation and migration of hepatoma cell BEL-7402 and their mechanisms [J]
Progress and extensive meaning of mammalian target of Rapamycin involved in restoration of nervous system injury
Akt/mammalian target of Rapamycin counteract the antitumor activities of cixutumumab an anti-insulin-like growth factor I receptor monoclonal antibody
β‐hydroxy‐β‐methyl butyrate (HMB) stimulates mammalian target of Rapamycin complex 1 (mTORc1) signaling via a phosphatidylinositol‐3‐kinase (PI3K)‐dependent …
The study on the clinical efficacy of Rapamycin eluting stent in patients with multivessel coronary disease [J]
Rapamycin Inhibits Proliferation and Invasion of Human Bladder Carcinoma Cell Line T24 in vitro
Rapamycin Delays Xenogeneic Acute Graft Versus Host Disease (aGVHD) in Nod/Scid/Il2RγNull (NSG) Mice: Impact of Regulatory T Cells
Is There a Role for Mammalian Target of Rapamycin inhibition in Renal Failure due to Mesangioproliferative Nephrotic Syndrome?
Effect of casamino acid on intergeneric conjugation in Rapamycin-producing Streptomyces hygroscopicus ATCC29253
Does Rapamycin Still Have a Role? Experience and Lessons from the Last Decade: 1116
Rapamycin pre-treatment abrogates Tumour Necrosis Factor-α down-regulatory effects on LXR-Î±and PXR mRNA expression via inhibition of c-Jun N …
Resveratrol, Rapamycin and MG‐132 as inducers of autophagy in ARPE‐19 cells
The Effect of Low-dose Rapamycin on Prolonging High-Risk Corneal Allograft Survival in a Mouse Model
Rapamycin pre-treatment abrogates Tumour Necrosis Factor-a down-regulatory effects on LXR-a and PXR mRNA expression via inhibition of c-Jun N-terminal …
Can Rapamycin Improve Cognitive Problems Caused by Chemotherapy?
Abstract B111: Early and Delayed Rapamycin prevents NNK-induced lung adenocarcinoma in A/J mice
Strain Development and Optimization of Small Scale Culture Condition for Improving Rapamycin Production
Systemic Immunomodulation with SA-FasL Protein-Engineered Donor Splenocytes Under Transient Cover of Rapamycin Induces Robust Tolerance to Cardiac …
Rapamycin does not control hemophagocytic lymphohistiocytosis in LCMV‐infected perforin‐deficient mice
Therapeutic effects of Rapamycin on experimental autoimmune uveoretinitis
A feasibility study of Rapamycin with hyper-CVAD chemotherapy in adults with acute lymphoblastic leukemia (ALL) and other aggressive lymphoid malignancies and …
Studies on inhibitory effect of Rapamycin on growth and metastasis of PC3 cells
THE EXPRESSION OF GENES ASSOCIATED WITH OSTEOBLAST DIFFERENTIATION AND THE MAMMALIAN TARGET OF Rapamycin (mTOR) IN THE BLOOD …
P7170, a novel inhibitor of phosphoinositide 3-kinase (PI3K)-mammalian target of Rapamycin (mTOR) and activin receptor-like kinase 1 (ALK1) as a new therapeutic …
Hormonal and nutrient signalling to protein kinase B and mammalian target of Rapamycin in pancreatic beta-cells
PS212. Peri-Adventitial Delivery of a Nanoparticle Albumin-Bound Rapamycin Reduces Luminal Stenosis in a Porcine Femoral Artery Balloon Injury Model
Comparative study of immunosuppression of HuangQi glycoprotein, triptolide, Rapamycin and hydrocortisone in vitro [J]
Effects of Rapamycin on immune function of T1DM mouse and the related molecular mechanism
Chronic Treatment with Rapamycin Attenuates Diabetes-Associated Adverse Effects and Protects Against Myocardial Ischemia/Reperfusion Injury in Type II Diabetic …
Role of the Mammalian Target of Rapamycin (mTOR) Signalling Pathway in Podocytes in Glomerular Disease
TCT-601 Real-world experience of the polymer-free Rapamycin-eluting YUKON-Choice stent: five-year results from a prospective registry
Correction: inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer’s Disease
1081 the number of aberrantly expressed constituents of the mammalian target of Rapamycin pathway: correlation with oncologic outcomes in clear cell renal cell …
The FKBP-Rapamycin binding domain of human TOR undergoes strong conformational changes in the presence of membrane mimetics with and without the regulator …
Effects of Rapamycin-induced oligomerization of parvalbumin, Stim1 and Orai1 in puncta formation
Differential Modulation of mTORC1 and mTORC2 Signaling by Rapamycin During Pro-Arteriosclerotic Differentiation of Mesenchymal Stem Cells: 1485
Development of mammalian target of Rapamycin inhibitors
Translational research of the relationship between Rapamycin and hepatocellular carcinoma
Effects of Rapamycin on the Expression of HIF-1α and VEGF in Leukemic Cell Lines SUP-B15
NVP-BEZ235, A Dual Inhibitor of Phosphoinositol-3-Kinase (PI3K) and Mammalian Target of Rapamycin (mTOR), Is a Potent Inhibitor of Lymphoma Cell Growth and …
Rapamycin: Advantages of Immunosuppressive Therapy with Less Neurotoxicity (P04. 166)
Study on the Effects of Rapamycin Reverse AMN107 resistance on k562/AO2 Cells
Activation of AMP-activated protein kinase (AMPK) enhances Radiosensitization via inhibition of mTOR pathway in Rapamycin-resistant non-small cell lung cancer …
Neuroprotective Effect of Rapamycin in Optic Nerve Transection Model
Rapamycin enhances chemosensitivity of endometrial cancer cells to adriamycin [J]
Inhibitory effects of Rapamycin on proliferation of chronic myelogenous leukemia cells and its mechanism
The Effects of Rapamycin on Endothelial Cell Migration and Vascular Endothelial Growth Factor Expression
Oral Rapamycin prevents artery restenosis after stent implantation by inhibiting mammalian target of Rapamycin (mTOR)
Translation of 5′ terminal oligopyrimidine tract (5′ TOP) mRNAs in Aplysia californica is regulated by the target of Rapamycin (TOR)
S35 Rapamycin inhibits IL-33-induced, nuocyte-driven airway inflammation
Effect of Dose and Standard Therapy on the Anti-Remodeling Effects of Rapamycin in Experimental Heart Failure
Efficacy of the program of Rapamycin combined with CNI in chronic allograft nephropathy
Mammalian target of Rapamycin in gastric cancer
Rapamycin Impacts T Cell Associated Markers In A Model Of Acute Lung Injury
6intact plasticity and learning in Rheb1 mUtant mice: implications for Rapamycin treatments
NF-κB Mediates Resistance to Rapamycin in Neuroblastoma
Abstract A175: Role of MnSOD and hydrogen peroxide in Rapamycin-induced cytostasis.
Preparation and Characterization of Rapamycin incorporated drug delivery carrier
Study on the protective effects of Rapamycin on cerebral ischemia-reperfusion injury in rats
STUDY OF ANTITUMOR EFFECT OF Rapamycin ON HUMAN HEPATOCELLULAR CARCINOMA HEPG-2 CELLS IN VITRO
Low Dose Rapamycin Exacerbates Autoimmune Experimental Uveitis
Targeting the target of Rapamycin (TOR): looking to mother nature
Research on the pharmaceutical distribution of Rapamycin nanometer vector eye drop in rabbit eyes
Paradoxical effect of Rapamycin on S6 phosphorylation in rats with or without seizures
Inhibitory effects of Rapamycin on proliferation and migration of human umbilical vein endothelial cells
Enzymatic and biochemical characterization of the Target Of Rapamycin (TOR) signaling pathway
Effects of Rapamycin on mTOR Signaling Pathway in Human Pancreatic Cancer Cell Line SW1990
Immunosuppressants FK506 and Rapamycin function as reversal
Rapamycin prevents muscle growth and the increase in MHCIIa induced by voluntary wheel running
Rapamycin aggravates experimental non alcoholic steatohepatitis in mice
Application of macroporous adsorption resin in separation and purification of Rapamycin
Determination of Rapamycin in blood vessel of dogs by LC-MS/MS
Effects of Rapamycin on cholesterol homeostasis and secretory function of 3T3-L1 cells
Mammalian target of Rapamycin: Immunosuppressive drugs
Rapamycin increases the sensitivity of glioma-initiating cells to radiation
Rapamycin dose-dependently promotes differentiation and cell death in an in vitro model of malignant gliomas
… of soluble interleukine-2 receptor in blood of patients with ischemic heart disease after coronary artery angioplasty with implantation of stents with Rapamycin covering
Inhibitory effects of Rapamycin on proliferation of chronic myelogenous leukemia cells and its mechanism
Effects of intrathecal injection Rapamycin on neuropathic pain behaviors in mice
The Immunosuppressive Drug Rapamycin Inhibits Several Molecular Mechanisms Involved in Tummor Development: 1648
Role of Rapamycin-Induced Autophagy in Pancreatic B-Cell Function: 1326
Preparation and characterization of Rapamycin nanoparticles and its effect in vein graft
Rapamycin administration does not impair basal protein metabolism in human skeletal muscle
Modulation of gastric nesfatin by Rapamycin
P7170: A potent and oral phosphoinositide 3-kinase (PI3K)-mammalian target of Rapamycin (mTOR) and activin receptor-like kinase 1 (ALK1) inhibitor with anti-tumor …
Rapamycin Reduces Reactive Oxygen Species in Cultured Human Corneal Endothelial Cells
The role of Tacrolimus and Rapamycin on recurrence in HCC patients after liver transplantation
Oral Rapamycin Therapy Confers Protection Against Pneumococcal Pneumonia In Young Mice
Effect of Rapamycin inhibit liver fibrosis in rat with obstructive jaundice
Mechanisms of Rapamycin Toxicity in Pancreatic Beta Cells
Characterization of the Mechanistic Target of Rapamycin in the Mouse Ovary
Mammalian target of Rapamycin inhibitors and tumor therapy
The Role of Mammalian Target of Rapamycin in Hypertensive Rat Atria
Abstract C225: Differential regulation of simultaneous antitumor and alloreactive CD8+ T cell responses in the same host by Rapamycin.
Rapamycin Increases Infarct Size and is Detrimental During Acute Ischemia-Reperfusion
Rapamycin to prevent artery restenosis after stent implantation: an intravascular ultrasound study [J]
Effects of intrathecal injection Rapamycin on neuropathic pain bahaviors in mice: 14AP4-4
The effects of Rapamycin on the proliferation and apoptosis of human retinal pigment epithelium cells in vitro
Growth factor dependent regulation of p70S6 kinase: Evaluation of domain specific signals sensitive to Rapamycin
Clinical response to intravitreal Rapamycin in a retinal neovascularization model
Rapamycin-induced alteration of the DC maturation process sustains their capacity to induce regulatory T cells
… The ATP-competitive mammalian target of Rapamycin (mTOR) inhibitors suppress proliferation and induce apoptosis in the acquired Rapamycin resistant breast cancer …
Nanoparticles For Delivery Of Rapamycin To Glioblastoma And Glioblastoma-Derived Stem Cells
Adjuvant Rapamycin Improves The Outcomes Of Severe H1N1 Pneumonia And Acute Respiratory Distress Syndrome
Characterization of the yeast Rapamycin-sensitive phosphoproteome
Rapamycin in patients with advanced hepatocellular carcinoma progressing on prior antiangiogenic therapy.
Rapamycin Reduces TNF-α mRNA via Regulating 3’AU Rich Element Region
Apoptosis of renal cells induced by TNF-α and NF-κB in diabetic rats and intervention of Rapamycin
inhibition of Mammalian Target of Rapamycin (mTOR) in Epidermis
Comparison of the efficacy of FK506 and Rapamycin application on liver cancer liver transplant patients after surgery
Abstract P212: Haploinsufficiency of Target of Rapamycin Attenuates Different Forms of Cardiomyopathies in Adult Zebrafish
Antitumor activity of Rapamycin in combination with ectopic expression of Beclin 1 in multidrug‐resistant cancer cells
Tumor necrosis factor-related apoptosis-inducing ligand participates in injury of vascular endothelial cells induced by Rapamycin in vitro
Advances in Technology Based on the Combination of Rapamycin and FRB Domain Mediated Protein-protein Interactions
Structural characterization of Rapamycin and its analoges by electrospray ionization mass spectrometry
Long-term oral delivery of encapsulated Rapamycin is not detrimental to immunity in old mice (178.11)
Role of Rapamycin target protein signal transduction in regulating muscle volume
Rapamycin inhibits generation of memory CD8 T cells that localize to mucosal tissues (46.23)
Effect of Rapamycin and metformin on skin tumor promotion in mice overweight and obese
Effects of low dosage Rapamycin on expression of the vascular endothelial growth factor in diabetic nephropathy rats
Mammalian Target of Rapamycin Inhibitors in Breast Cancer Therapy
Effect of Rapamycin on Filamentous Fungal Cell Walls
Chronic Rapamycin administration maintains mitochondrial protein synthesis in heart and skeletal muscle
Insulin-Like Peptides and the Target of Rapamycin Pathway Coordinately Regulate Blood
Observation on the Clinical Effects of Domestic-made Rapamycin Drug-eluting Stents for Treatment of Ischemic Cardiomyopathy [J]
Rapamycin prevents experimental sclerodermatous chronic graft-versus-host disease in mice
Effect of Rapamycin on Aspergillus nidulans cell wall material properties
Prediction of the course of osteoarthrosis from mTOR (mammalian target of Rapamycin) gene expression
The influence of Rapamycin on BTLA expression of human peripheral blood T lymphocytes
Nesfatin-1 action in the brain increases insulin sensitivity through Akt kinase/AMP-dependent protein kinase/target of Rapamycin complex 2 pathway in diet …
Study on the effect of Rapamycin on RelB expression of immature dendritic cell
Rapamycin Inhibits Innate and Adaptive Immune Functions of Human Plasmacytoid Dendritic Cells: 2003
Akt/mammalian Target of Rapamycin Counteract the Akt/mammalian Target of Rapamycin Counteract the Growth Factor I Receptor Monoclonal Antibody
Rapamycin attenuates the development of chronic hypoxia-induced pulmonary hypertension in mice
Expression and clinical significance of phosphorylation of mammalian target protein of Rapamycin in human glioma
Effect of Rapamycin on the cyclosporin A-resistant CD28-mediated costimulatory pathway
Differential Rapamycin sensitivity distinguishes two distinct populations of tumor cells in murine glioma
Rapamycin Reverses Fibrotic Differentiation Of Mesenchymal Stromal Cells From Human Lung Allografts
Effect of Rapamycin on the expression of transforming growth factor and osteopontin in the diabetic nephropathy rats
CD44-Tropic Polymeric Nanocarrier for Breast Cancer Targeted Rapamycin
Effect of Rapamycin on expressions of connective tissue growth factor and fibronectin in renal interstitial fibroblasts
The Effectiveness of Foxp3+ Treg on Carcinoma of Liver Transplantation in Tacrolimus and Rapamycin
Separation of Rapamycin from fermentation broth using high-speed counter-current chromatography
Collagen from Aged Mice Exposed to Short-term Caloric Restriction and Rapamycin Display Unique Properties
Lymphoid Hyperplasia In A Patient With Common Variable Immunodeficiency Treated With Steroids And Rapamycin
Study on the Effects of Rapamycin on Cell Proliferation, Apoptosis and Autophagy in Human Acute Lymphoblastic Cell Line SUP-B15
EFFECTS OF INHIBITING THE MAMMALIAN TARGET OF Rapamycin (mTOR) PATHWAY AND TELOMERASE IN BREAST CANCER CELLS
Rapamycin Causes miRNA-20a Mediated Suppression of Egln3/prolylhydroxylase-3 and Protects against Ischemia/Reperfusion Injury in Type II Diabetic Heart
Real-time Therapeutic Window of Blood Concentration of Rapamycin in Recipients of Renal Transplantation Determined by Microparticle Enzyme Immunoassay …
Rapamycin inhibition of TorC1 and nitrogen limitation control Gln3 and Gat1 localization by distinct regulatory pathways
Identification of a new tumor suppressor pathway modulating Rapamycin sensitivity in colorectal cancer
Effect of mammalian target of Rapamycin on side population cells in hepatocellular carcinoma cell line Hep3B
Comparison of the inhibitory effect of Rapamycin and Pirarubicin on bladder cancer T24 cell [J]
Acute Rapamycin treatment augments both protein ubiquitination and Akt activation in pressure‐overloaded rat myocardium
The enhancement of radio-sensitivity via autophagy induced by Rapamycin with glioma-initiating cells in vivo
Ryanodine downregulates the expression of p-eNOS (Thr495) and improves the functions of Rapamycin treated endothelial outgrowth cells
The effect of long-term Rapamycin treatment on hippocampal synaptic function in a mouse model of Alzheimer’s disease
Abstract P117: Does Mammalian Target of Rapamycin Complex-2 Regulate Protein Degradation Pathways in the Heart?
Phase I Study of Decitabine and Rapamycin in Relapsed/Refractory Acute Myelogenous Leukemia
Five-year follow-up of China-made firebird Rapamycin drug-eluting stent in elderly patients with acute ST elevation myocardial infarction [J]
Synergistic Effect of Flt3L and Rapamycin On Immune Tolerance Induction Via Plasmacytoid Dendritic Cells and Treg.
Primary discuss on flow-cell elution release test method at stability of Rapamycin on drug-eluting stents
Abnormal Retinal Ganglion Cell Activity Is Attenuated By Rapamycin In A Mouse Model Of Tuberous Sclerosis
Target of Rapamycin Regulates Development and Ribosomal RNA Expression through Kinase Domain in Arabidopsis1 [W][OA]
Interaction effects between AMP-activated protein kinase and mammalian target of Rapamycin signaling pathways Symbol
The Effects of Rapamycin and Stromal Cell Derived Factor-1α on the Biological Function of Endothelial Outgrowth Cell
The Effects of Rapamycin on Expression of Hypoxia Signal Molecules in Human Acute Myeloid Leukemic Cell Line HL-60 Under Hypoxia
The mTOR inhibitor, Rapamycin, sensitises solid tumour cell lines to isoprenoid induced toxicity
THE ANTI-RESTENOSIS EFFECTS OF Rapamycin AND PACLITAXEL ELUTING STENT IN SUSSCROTA DOMESTICA CORONARY ARTERY
Transcriptional regulation of gene expression during osmotic stress responses by the mammalian target of Rapamycin
Rapamycin and Adiponectin in Vascular Smooth Muscle Cells: Implications in the Development of Drug-Eluting Stents
Calcineurin Inhibitor Transfer to Rapamycin Can Improve Graft Function in Living Donor Kidney Transplantation with Older Donors: 580
Mammalian Target Of Rapamycin In Combination With Chemotherapy: Upstream Regulation Of Anaerobic Glycolysis To Target The Chemoresistant Cell Population …
Rapamycin increased development of CD4~+ CD25~ h ighFoxp3~+ T cells of peripheral blood in liver transplant recipients
Preparation and characterization of Rapamycin-loaded nanoemulsions as an approach for increasing anti-proliferative activity. i. phase behavior study
The Effects Of Mitomycin, Rapamycin And Bevacizumab On Corneal Haze After Photorefractive Keratectomy
THE mTORC1 INHIBITOR Rapamycin INDUCES A SPECIFIC PRO-INFLAMMATORY PHENOTYPE FAVORING IL-12 IN LPS-STIMULATED IMMUNE CELLS …
Rapamycin Reduces Macrophages While Cyclosporine A Reduces Neutrophils In The Retina In Mouse Endotoxin-induced Uveitis
Preemptive Use of Mammalian Target of Rapamycin Inhibitors in Living Donor Transplantation
Role of Rapamycin in protection against cerebral ischemia-induced brain injury is related to neurogenesis in discrete brain regions in rat
Rapamycin prolongs overall survival and progression-free survival in a mouse model of lung cancer in never smokers resistant to erlotinib
… imaging of kidney cysts: volumetric assessment in patients affected by autosomal dominant polycystic kidney disease (ADPKD) type I in treatment with Rapamycin
Perifosine inhibits growth of Rapamycin resistant cells through activating GSK3β
Rapamycin and Podocyte Apoptosis/Injury in Renal Allograft Biopsies: 2290
Application of Rapamycin-Eluting Stent with Biodegradable Polymer Coating in Patients Receiving Emergency Percutaneous Coronary Intervention
Rapamycin is a Deceptive Tool for Probing Functional Interactions Between FK506-Binding Proteins and Ryanodine Receptors
Rapamycin inhibits lymph node metastasis in an orthotopic model of head and neck squamous cell carcinoma: A possible role for a suppression of VEGFR-3 …
Mammalian Target of Rapamycin and Tristetraprolin Regulate Iron Homeostasis in Cardiac Cells
Cytotoxic and cystostatic properties of Rapamycin are due to differential effects on the phosphorylation of mTORC1 substrates S6 kinase and 4E-BP1
The differential effects of prenatal and/or postnatal Rapamycin on neurodevelopmental defects and cognition in a neuroglial mouse model of tuberous sclerosis …
ARABIDOPSIS LST8 proteins interact with target of Rapamycin and over-expression of LST8 results in plants being hypersensitive to light
Study on autophagy induced by Rapamycin in melanoma cell line M14 and changes in the expression of Bcl-2 and Bax in progress of autophagy
Mammalian target of Rapamycin (mTOR) inhibitors in pediatric kidney transplantation: A systematic review
The Effect of Rapamycin Paired with Traumatic Memory Activation on Cognitive Performance in Veterans Diagnosed with PTSD
Mammalian Target of Rapamycin (mTOR) inhibition Attenuates Angiotensin II-Induced Hypertension and Endothelial Dysfunction
Rapamycin Treatment Shifts Balance of Autophagy and Apoptosis during Murine Cytomegalovirus (MCMV) Infection of the Retina or RPE Cells
Combination of Rapamycin with sorafenib as a therapeutic strategy against colorectal cancers with mutational activation of KRAS and PIK3CA
Abstract A75: Calorie restriction and Rapamycin, but not exercise, inhibit mammary tumor growth in a mouse model of postmenopausal obesity
Regulatory role of the mechanistic target of Rapamycin (mTOR) on the expression of osmotic stress response genes in mammalian cells
Effect Of Rapamycin And IL-2 On Regulatory CD4+ CD25+ Foxp3+ T Cells In Mice After Allogenic Penetrating Keratoplasty
Why is Rapamycin effective against Kaposi sarcoma? An analysis of molecular pathways reveals posttranslational silencing of PTEN
Interaction between the rabphillin-3A-like gene and phosphorylation of mammalian target of Rapamycin (mTOR) in colorectal cancer
Rapamycin increased development of CD4+ CD25high Foxp3+ T cells of peripheral blood in liver transplant recipients
Enhancement of the long term efficacy of BCG vaccine against experimental tuberculosis in mice through Rapamycin induced modulation of CD4 and CD8 T cell …
Heterogeneity In Responsiveness Of Mesenchymal Stromal Cell From Individual IPF Patients To mTOR Inhibitor Rapamycin And Its Correlation To Dysregulation In …
Efficacy of homemade biodegradable Rapamycin drug-eluting stent implantation: Compared with bare-metal stents
Glutamine starvation and Rapamycin inhibition of TorC1 elicit transcription of distinct groups of nitrogen‐responsive genes
Preclinical efficacy of AZD8055, an ATP-competitive mammalian target of Rapamycin (mTOR) kinase inhibitor, in vitro in urothelial carcinoma of the bladder
Effects of RhoC-siRNA combined with Rapamycin on invasion and metastasis of hepatocellular carcinoma cell Bel7402
Resistance to silvestrol is mediated by MDR1/Pgp over-expression in a lymphoblastic leukemia cell line and is reversible by treatment with Rapamycin
Identification of interacting partners of mammalian target of Rapamycin complex 1 (mTORC1) assembly in human lymphocytes
Statins and Rapamycin synergistically induce dendritic cell KLF2 expression and tolerogenic function in vivo (P1610)(56.8)
Chronic Rapamycin Treatment Causes a Deficit in Optokinetic Tracking in Male Mice and Does Not Prevent Tracking Deficits in the Ins2Akita Mouse Model of Diabetic …
inhibition of mammalian target of Rapamycin (mTOR) signaling by Temsirolimus as a potential therapeutic strategy for esophageal cancer treatment
PIM kinase inhibition blocks activation of mTOR pathway components and enhances Rapamycin-mediated tumor growth inhibition in prostate cancers
Evaluation of polymer-free paclitaxel-eluting stents versus biodegradable polymer-based Rapamycin-eluting stents in treatment with coronary heart disease
Mammalian target of Rapamycin regulate kidney oxygen consumption by controlling mitochondrial function via regulation of uncoupling protein 2
Mammalian Target of Rapamycin Regulates Cardiac Iron Homeostasis in vitro and in vivo through Modulation of Tristetraprolin Expression
Functional analysis of the single Est1/Ebs1 homologue in K. lactis reveals roles in both telomere maintenance and Rapamycin resistance
Abstract P6-11-03: Site-Specific, Concomitant Delivery of Rapamycin and Paclitaxel in Breast Cancer: Consequent Synergistic Efficacy Enhancement
Amino Acids and Insulin are Both Necessary for an Amplified Response of Protein Synthesis Through the Mammalian Target of Rapamycin Signaling Pathway
Selective ATP-competitive inhibitors of TOR suppress Rapamycin insensitive function of Torc2 in S. cerevisae
WITHDRAWN: Mammalian target of Rapamycin (mTOR) inhibition in polycystic kidney disease (PKD): From bench to bedside
P-459 Role of the mammalian target of Rapamycin (mTOR) during human follicular development
IL-12hi Rapamycin-Conditioned Dendritic Cells Mediate IFN-γ-Dependent Apoptosis of Alloreactive CD4+ T Cells and Limit Graft-Versus-Host Diseas
Genetic variants in the mammalian target of Rapamycin (mTOR) signaling pathway as predictors of clinical response and survival in women with ovarian cancer
Re: Mammalian Target of Rapamycin (mTOR) Regulates Cellular Proliferation and Tumor Growth in Urothelial Carcinoma
Dual-frequency ultrasound-mediated delivery of Rapamycin from microbubbles decreases drug dose needed to reduce neointima formation in vivo
In vitro profibrotic effects of Rapamycin on basal or TGF-β1 induced primary human lung fibroblast: ECM production and turnover, migration and differentiation
Immune Blot Analysis on Expression of the Mammalian Target of Rapamycin in Goat Fetal Fibroblasts with Recombinant Polyclonal Antibody
Abstract LB-7: HPV-associated HNSCC: widespread mTOR pathway activity and preclinical evaluation of mTOR inhibitors Rapamycin and RAD-001
Oral Rapamycin to Reduce Intimal Hyperplasia After Bare Metal Stent Implantation-A Prospective Randomized Intravascular Ultrasound Study
The mammalian target of Rapamycin complex 2 (mTORC2) negatively regulates the innate inflammatory response
Tacrolimus and Rapamycin do not elevate cholesterol synthesis in post‐transplant patients, but may impair response to multi‐nutrient dietary intervention
First report of a novel abluminal groove filled biodegradable polymer Rapamycin-eluting stent inde novocoronary artery disease: results of the first in man FIREHAWK …
Can negative biomarkers be helpful? A novel combination test to predict non-response to inhibition of the mammalian target of Rapamycin (mTOR) pathway in …
… Therapeutic Potential of Targeting Dysregulated Signaling Axes in Squamous Cell Carcinoma: Another Kinase of Transcription and Mammalian Target of Rapamycin
Genetic variants in the mammalian target of Rapamycin (mTOR) signaling pathway as predictors of survival and clinical response in women with ovarian cancer
Re: Hypoxia-Inducible Factor and Mammalian Target of Rapamycin Pathway Markers in Urothelial Carcinoma of the Bladder: Possible Therapeutic Implications
Rapamycin-insensitive mTORC1 activity controls eIF4E: 4E-BP1 binding [version 1; referees: 3 approved]
Combination of LC3 II shRNA and genistein completely inhibited Rapamycin-induced autophagy and promoted apoptosis in human malignant neuroblastoma cell lines
Rapamycin Enhances Protective Effect of Sildenafil against Doxorubicin Cardiotoxicity and Potentiates Cancer Cell Killing
… type CD8+ t-cells correlates with the failure of early immunosuppression withdrawal after cadaver liver transplantation using high doses atg induction and Rapamycin
P158 All-trans retinoic acid and Rapamycin synergize with transforming growth factor-B to induce regulatory T cells but confer distinct in vivo migratory capacities
IL-12hi Rapamycin-Conditioned Dendritic Cells Induce Apoptosis of Alloreactive CD4+ T Cells in an Ifn-γ-Dependent Manner and Inhibit Graft-Versus-Host Disease
Mammalian target of Rapamycin (mTOR) signaling proteins are highly expressed in mamamry tumors of MMTV-TGF-β mice
NOVEL INSIGHTS INTO BONE MORPHOGENETIC PROTEIN (BMP) AND MAMMALIAN TARGET OF Rapamycin (mTOR) SIGNALING AXIS IN PROSTATE …
To assess coronary atherosclerotic plaque by IVUS-VH and the level of hs-CRP in serum, to observe is involved Rapamycin-eluting in-stent restenosis
A Stable Chitosan-coated Nanomicelle Combination Of Vitamin E-TPGS And Cholesterol-PEG For The Topical Administration And Scleral Retention Of Rapamycin
Risk of rash and stomatitis with everolimus, a mammalian target of Rapamycin (mTOR) inhibitor: A meta-analysis.
Selective ATP-competitive inhibitors of TOR suppress Rapamycin insensitive function of TORC2 in S. cerevisiae
P94 Rapamycin helps maintain the regulatory phenotype of cytochrome P450IID6-specific Treg expanded from patients with autoimmune hepatitis type 2 by reducing …
Mammalian Target of Rapamycin Inhibitor and Anti-Death Receptor Agonistic Antibody: a Novel Combination Therapy for the Treatment of Hepatocellular Carcinoma …
A Global Kinase and Phosphatase Interaction Network in the Budding Yeast Reveals Novel Effectors of the Target of Rapamycin (TOR) Pathway
CD4 T helper cell profiling in heart and liver transplant recipients: Comparison between CNI-, Rapamycin-and anti-CD25 mAB-based immunosuppression
Rapamycin Eluting Biodegradable Extravascular Stent Prevents Vein Graft Stenosis at Long Term in a Canine Model
Risk of rash and stomatitis with temsirolimus, a mammalian target of Rapamycin (mTOR) inhibitor: A meta-analysis.
Differential effects of Rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4+CD25+FOXP3+ Treg subpopulations
Combined grape polyphenols regulate mammalian target of Rapamycin (mTOR) signaling via a dual mechanism of Akt inhibition and AMPK activation
ET-04. COMBINED MYXOMA VIROTHERAPY WITH Rapamycin TARGETING BRAIN TUMOR-INITIATING CELLS
Mammalian Target of Rapamycin Signal Inhibitors (imTOR) Use in First and Relapse BK Polyomavirus Nephritis (BKVN) in Renal Allograft Recipients: 2556
Adventitial Nab-Rapamycin Injection Reduces Porcine Femoral Artery Luminal Stenosis Induced by Balloon Angioplasty via inhibition of Medial Proliferation and …
IL-12 combined with Rapamycin enhances the ellular immunity induced by PRRS attenuated vaccine
UCHL1 protein synthesis upon Rapamycin treatment involves its antisense RNA trough embedded SINEB2 repeat
Evaluation of NIH-Defined Chronic Graft-Versus-Host-Disease in a Rapamycin-Based Haploidentical Stem Cell Transplantation: Analysis of 113 Consecutive Patients …
The Internal Ribosome Entry Site-Medaited Expression of VEGF Rescues HS Sultan Tumor Cells From Mammalian Target of Rapamycin (mTOR)-Inhibitors Induced …
Comparison between Oral Rapamycin Plus Bare Metal Stent versus Drug Eluting Stent for the Prevention of Restenosis in the Treatment of Coronary Disease with …
Rapamycin delays xenogeneic acute graft-versus-host disease (aGvHD) in NOD/SCID/IL2Rg NULL (NSG) mice: impact of regulatory T cells
Effects of 1-methyl-4-phenyl pyridinium on mammalian Rapamycin target signaling pathway in human neuroblastoma cells
1070 DEVELOPMENT OF A Rapamycin SENSITIVE CELL LINE FROM UROTHELIAL CARCINOMA WITH SARCOMATOID FEATURES
The mTOR inhibitor Rapamycin delays xenogeneic acute graft versus host disease (aGVHD) in NOD/SCID/IL2rgnull mice (NSG): impact of regulatory T cells
… CELLS AGAINST HYPOXIA AND SERUM DEPRIVATION-INDUCED APOPTOSIS VIA AMP-ACTIVATED PROTEIN KINASE/MAMMALIAN TARGET OF Rapamycin …
Mammalian Target of Rapamycin Inhibitors Versus Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitors (VEGF TKI) as Second-Line Therapy in …
Marinobufagenin induced uremic cardiomyopathy: the role of passive immunization, Rapamycin, and CD40 signaling in the generation of renal fibrosis
inhibition of Mammalian Target of Rapamycin (mTOR) Complex 1 and 2 by PP242 Induces G1 Growth Arrest in Pancreatic Ductal Adenocarcinoma and when …
Preconditioning with Rapamycin and CTLA4-Ig in Dogs Given Donor Antigen and 1Gy Total Body Irradiation (TBI) Before Dog-Leukocyte-Antigen (DLA)-Identical …
Rapamycin: one drug, many effects
Duration of Rapamycin treatment has differential effects on metabolism in mice
Rapamycin extends life and health in C57BL/6 mice
Longevity, aging and Rapamycin
Rapamycin unbalances the polarization of human macrophages to M 1
Rapamycin extends murine lifespan but has limited effects on aging
Mammalian target of Rapamycin signaling in cardiac physiology and disease
Evidence for Rapamycin toxicity in pancreatic β-cells and a review of the underlying molecular mechanisms
The role of target of Rapamycin signaling networks in plant growth and metabolism
Rapamycin, autophagy, and Alzheimer’s disease
mTORC1 phosphorylation sites encode their sensitivity to starvation and Rapamycin
Rapamycin extends life-and health span because it slows aging
Rapamycin inhibits the growth of glioblastoma
Late‐life Rapamycin treatment reverses age‐related heart dysfunction
Rapamycin and aging: when, for how long, and how much?
Mammalian target of Rapamycin (mTOR) pathways in neurological diseases
Rapamycin increases survival in ALS mice lacking mature lymphocytes
MIR181A regulates starvation- and Rapamycin-induced autophagy through targeting of ATG5
A diverse array of cancer-associated mTOR mutations are hyperactivating and can predict Rapamycin sensitivity
Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction
Mammalian target of Rapamycin (mTOR) inhibition with Rapamycin improves cardiac function in type 2 diabetic mice: potential role of attenuated oxidative …
Large FK506-binding proteins shape the pharmacology of Rapamycin
Rapamycin attenuates the development of posttraumatic epilepsy in a mouse model of traumatic brain injury
Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice
Systemic analysis of inducible target of Rapamycin mutants reveal a general metabolic switch controlling growth in Arabidopsis thaliana
Mechanistic target of Rapamycin complex 2 protects the heart from ischemic damage
Mice fed Rapamycin have an increase in lifespan associated with major changes in the liver transcriptome
RAB3GAP1 and RAB3GAP2 modulate basal and Rapamycin-induced autophagy
Rapamycin drives selection against a pathogenic heteroplasmic mitochondrial DNA mutation
Altered proteome turnover and remodeling by short‐term caloric restriction or Rapamycin rejuvenate the aging heart
Rapamycin allosterically inhibits the proteasome
Activation of mammalian target of Rapamycin and synaptogenesis: role in the actions of rapid-acting antidepressants
Induced regulatory T cells promote tolerance when stabilized by Rapamycin and IL-2 in vivo
Sugar metabolism and the plant target of Rapamycin kinase: a sweet operaTOR?
Therapeutic effects of Rapamycin on MPTP-induced Parkinsonism in mice
Rapamycin attenuates mitochondrial dysfunction via activation of mitophagy in experimental ischemic stroke
Rapamycin is neuroprotective in a rat chronic hypertensive glaucoma model
Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells
Rapamycin alleviates cisplatin-induced ototoxicity in vivo
Mutations in mammalian target of Rapamycin regulator DEPDC5 cause focal epilepsy with brain malformations
Rapamycin induces ILT3highILT4high dendritic cells promoting a new immunoregulatory pathway
Co-delivery of cisplatin and Rapamycin for enhanced anticancer therapy through synergistic effects and microenvironment modulation
Preserving youth: does Rapamycin deliver?
Mammalian target of Rapamycin inhibition in hepatocellular carcinoma
Convergence of ubiquitylation and phosphorylation signaling in Rapamycin-treated yeast cells
Rapamycin prevents seizures after depletion of STRADA in a rare neurodevelopmental disorder
The role of mechanistic target of Rapamycin (mTOR) complexes signaling in the immune responses
Mammalian target of Rapamycin inhibitor-associated stomatitis
Scopolamine rapidly increases mammalian target of Rapamycin complex 1 signaling, synaptogenesis, and antidepressant behavioral responses
Local intra-articular injection of Rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis
Rapamycin-induced metabolic defects are reversible in both lean and obese mice
Chronic Rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer’s …
Taking aim at Alzheimer’s disease through the mammalian target of Rapamycin
Rapamycin reverses pulmonary artery smooth muscle cell proliferation in pulmonary hypertension
Driving neural regeneration through the mammalian target of Rapamycin
Metabolomic response of Chlamydomonas reinhardtii to the inhibition of target of Rapamycin (TOR) by Rapamycin
Rapamycin rescues ABT-737 efficacy in small cell lung cancer
Chronic Rapamycin treatment causes diabetes in male mice
Mammalian target of Rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review
Weekly administration of Rapamycin improves survival and biomarkers in obese male mice on high‐fat diet
Hepatic signaling by the mechanistic target of Rapamycin complex 2 (mTORC2)
Rapamycin encapsulated in dual-responsive micelles for cancer therapy
Molecular determinants of outcome with mammalian target of Rapamycin inhibition in endometrial cancer
Rapamycin, anti-aging, and avoiding the fate of Tithonus
Molecular and genetic crosstalks between mTOR and ERRα are key determinants of Rapamycin-induced nonalcoholic fatty liver
Rapamycin protects the mitochondria against oxidative stress and apoptosis in a rat model of Parkinson’s disease
Short-term treatment with Rapamycin and dietary restriction have overlapping and distinctive effects in young mice
Rapamycin extends life span of Rb1+/− mice by inhibiting neuroendocrine tumors
Differential effects of Rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4+ CD25+ FOXP3+ T regulatory cell …
Rapamycin suppresses brain aging in senescence-accelerated OXYS rats
Sustained inhibition of receptor tyrosine kinases and macrophage depletion by PLX3397 and Rapamycin as a potential new approach for the treatment of MPNSTs
Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage
Mammalian target of Rapamycin (mTOR) mediates tau protein dyshomeostasis: implication for Alzheimer disease
Rapamycin reverses insulin resistance (IR) in high-glucose medium without causing IR in normoglycemic medium
Mechanistic target of Rapamycin controls homeostasis of adipogenesis
Rapamycin limits the growth of established experimental abdominal aortic aneurysms
Lamins are Rapamycin targets that impact human longevity: a study in centenarians
Multifaceted effects of Rapamycin on functional recovery after spinal cord injury in rats through autophagy promotion, anti-inflammation, and neuroprotection
A systematic review of conversion from calcineurin inhibitor to mammalian target of Rapamycin inhibitors for maintenance immunosuppression in kidney transplant …
Beneficial metabolic effects of Rapamycin are associated with enhanced regulatory cells in diet-induced obese mice
Mechanistic target of Rapamycin (mTOR) is essential for murine embryonic heart development and growth
Mammalian target of Rapamycin regulates Nox4-mediated podocyte depletion in diabetic renal injury
Cell cycle regulation by the nutrient-sensing mammalian target of Rapamycin (mTOR) pathway
Mammalian target of Rapamycin promotes oligodendrocyte differentiation, initiation and extent of CNS myelination
Enhancing autophagy with activated protein C and Rapamycin protects against sepsis-induced acute lung injury
(R,S)-Ketamine Metabolites (R,S)-norketamine and (2S,6S)-hydroxynorketamine Increase the Mammalian Target of Rapamycin Function
Mechanistic target of Rapamycin inhibition extends cellular lifespan in dendritic cells by preserving mitochondrial function
Different patterns of Akt and ERK feedback activation in response to Rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells
Contact inhibition and high cell density deactivate the mammalian target of Rapamycin pathway, thus suppressing the senescence program
High‐dose Rapamycin blocks mossy fiber sprouting but not seizures in a mouse model of temporal lobe epilepsy
Rapamycin treatment improves neuron viability in an in vitro model of stroke
Genetic reduction of mammalian target of Rapamycin ameliorates Alzheimer’s disease-like cognitive and pathological deficits by restoring hippocampal gene …
Nitrogen source activates TOR (target of Rapamycin) complex 1 via glutamine and independently of Gtr/Rag proteins
The use of sirolimus (Rapamycin) in the management of refractory inflammatory bowel disease in children
RETRACTED: Rapamycin induces of protective autophagy in vascular endothelial cells exposed to oxygen–glucose deprivation
Weekly nab-Rapamycin in patients with advanced nonhematologic malignancies: final results of a phase I trial
M (o) TOR of pseudo-hypoxic state in aging: Rapamycin to the rescue
Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2
Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of Rapamycin (mTOR)
Mechanistic target of Rapamycin complex 1 expands Th17 and IL-4+ CD4− CD8− double-negative T cells and contracts regulatory T cells in systemic lupus …
Rapamycin upregulates autophagy by inhibiting the mTOR-ULK1 pathway, resulting in reduced podocyte injury
Colocalized delivery of Rapamycin and paclitaxel to tumors enhances synergistic targeting of the PI3K/Akt/mTOR pathway
Reduced mammalian target of Rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts
Assessment of mitochondrial biogenesis and mTORC1 signaling during chronic Rapamycin feeding in male and female mice
Rapamycin promotes podocyte autophagy and ameliorates renal injury in diabetic mice
A unique herpesviral transcriptional program in KSHV-infected lymphatic endothelial cells leads to mTORC1 activation and Rapamycin sensitivity
Mammalian target of Rapamycin as a rational therapeutic target for breast cancer treatment
Rapamycin decreases tau phosphorylation at Ser214 through regulation of cAMP-dependent kinase
mTOR signaling in liver regeneration: Rapamycin combined with growth factor treatment
Rapamycin-treated human endothelial cells preferentially activate allogeneic regulatory T cells
Low-dose Rapamycin (sirolimus) effects in autosomal dominant polycystic kidney disease: an open-label randomized controlled pilot study
Disruption of mammalian target of Rapamycin complex 1 in macrophages decreases chemokine gene expression and atherosclerosis
Mechanistic target of Rapamycin activation triggers IL-4 production and necrotic death of double-negative T cells in patients with systemic lupus erythematosus
Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by Rapamycin
A feasibility and efficacy study of Rapamycin and erlotinib for recurrent pediatric low‐grade glioma (LGG)
Targeted radiotherapy of prostate cancer with a gastrin-releasing peptide receptor antagonist is effective as monotherapy and in combination with Rapamycin
Antidepressant-like effect of ascorbic acid is associated with the modulation of mammalian target of Rapamycin pathway
Acute systemic Rapamycin induces neurobehavioral alterations in rats
Mammalian target of Rapamycin inhibitors for intractable epilepsy and subependymal giant cell astrocytomas in tuberous sclerosis complex
Effects of the mTOR inhibitor Rapamycin on monocyte-secreted chemokines
Efficacy of Rapamycin against glioblastoma cancer stem cells
Mammalian target of Rapamycin signalling modulates amino acid uptake by regulating transporter cell surface abundance in primary human trophoblast cells
Periadventitial application of Rapamycin-loaded nanoparticles produces sustained inhibition of vascular restenosis
Fructose leads to hepatic steatosis in zebrafish that is reversed by mechanistic target of Rapamycin (mTOR) inhibition
Rapamycin and interleukin-1β impair brain-derived neurotrophic factor-dependent neuron survival by modulating autophagy
Mammalian target of Rapamycin complex 2 (mTORC2) coordinates pulmonary artery smooth muscle cell metabolism, proliferation, and survival in pulmonary arterial …
Topical Rapamycin for angiofibromas in paediatric patients with tuberous sclerosis: follow up of a pilot study and promising future directions
Rapamycin up-regulation of autophagy reduces infarct size and improves outcomes in both permanent MCAL, and embolic MCAO, murine models of stroke
Rapamycin and everolimus facilitate hepatitis E virus replication: revealing a basal defense mechanism of PI3K-PKB-mTOR pathway
Mechanistic target of Rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function
Correction of glycogen storage disease type III with Rapamycin in a canine model
Mammalian target of Rapamycin and its downstream signalling components are activated in psoriatic skin
First left–right comparative study of topical Rapamycin vs. vehicle for facial angiofibromas in patients with tuberous sclerosis complex
Reprogramming of the microRNA transcriptome mediates resistance to Rapamycin
The role of diacylglycerol kinase ζ and phosphatidic acid in the mechanical activation of mammalian target of Rapamycin (mTOR) signaling and skeletal …
Mammalian target of Rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer’s disease pathology
Metabolic control by target of Rapamycin and autophagy during ageing-a mini-review
Rapamycin improves sociability in the BTBR T+ Itpr3tf/J mouse model of autism spectrum disorders
Inducing autophagy: a comparative phosphoproteomic study of the cellular response to ammonia and Rapamycin
Rapamycin nanoparticles target defective autophagy in muscular dystrophy to enhance both strength and cardiac function
Rapamycin enhances long-term hematopoietic reconstitution of ex vivo expanded mouse hematopoietic stem cells by inhibiting senescence
Effects of Rapamycin combined with low dose prednisone in patients with chronic immune thrombocytopenia
Rheb and mammalian target of Rapamycin in mitochondrial homoeostasis
Role of Akt and mammalian target of Rapamycin in functional outcome after concussive brain injury in mice
Conversion to mammalian target of Rapamycin inhibitors increases risk of de novo donor‐specific antibodies
Intra-articular administration of gelatin hydrogels incorporating Rapamycin–micelles reduces the development of experimental osteoarthritis in a murine model
Rapamycin rescues the poor developmental capacity of aged porcine oocytes
A Rapamycin-binding protein polymer nanoparticle shows potent therapeutic activity in suppressing autoimmune dacryoadenitis in a mouse model of Sjögren’s …
Prenatal Rapamycin results in early and late behavioral abnormalities in wildtype C57BL/6 mice
Rapamycin preserves the follicle pool reserve and prolongs the ovarian lifespan of female rats via modulating mTOR activation and sirtuin expression
inhibition of mammalian target of Rapamycin with Rapamycin reverses hypertrophic cardiomyopathy in mice with cardiomyocyte-specific knockout of PTEN
Skeletal muscle-derived myonectin activates the mammalian target of Rapamycin (mTOR) pathway to suppress autophagy in liver
Combined treatment of Rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver
Protection Against Epithelial Damage During Candida albicans Infection Is Mediated by PI3K/Akt and Mammalian Target of Rapamycin Signaling
Insulin and Target of Rapamycin signaling orchestrate the development of ovarian niche-stem cell units in Drosophila
Neuroprotective effects of autophagy induced by Rapamycin in rat acute spinal cord injury model
Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance
Isoleucine, leucine, methionine, and threonine effects on mammalian target of Rapamycin signaling in mammary tissue
The bromodomain and extra-terminal inhibitor CPI203 enhances the antiproliferative effects of Rapamycin on human neuroendocrine tumors
Rapamycin prevents drug seeking via disrupting reconsolidation of reward memory in rats
Target of Rapamycin signalling mediates the lifespan-extending effects of dietary restriction by essential amino acid alteration
Adjuvant treatment with a mammalian target of Rapamycin inhibitor, sirolimus, and steroids improves outcomes in patients with severe H1N1 pneumonia and acute …
Rapamycin inhibits the mTOR/p70S6K pathway and attenuates cardiac fibrosis in adriamycin-induced dilated cardiomyopathy
Mechanism of metformin-dependent inhibition of mammalian target of Rapamycin (mTOR) and Ras activity in pancreatic cancer: role of specificity protein (Sp) …
Beyond control of protein translation: what we have learned about the non-canonical regulation and function of mammalian target of Rapamycin (mTOR)
Mammalian target of Rapamycin complex 1 orchestrates invariant NKT cell differentiation and effector function
Dihydroartemisinin inhibits the mammalian target of Rapamycin-mediated signaling pathways in tumor cells
The rationale of targeting mammalian target of Rapamycin for ischemic stroke
Beneficial role of Rapamycin in experimental autoimmune myositis
MicroRNA-199a-3p regulates endometrial cancer cell proliferation by targeting mammalian target of Rapamycin (mTOR)
Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of Rapamycin (mTOR) pathway, through endoplasmic reticulum stress to induce …
Rapamycin has a beneficial effect on controlling epilepsy in children with tuberous sclerosis complex: results of 7 children from a cohort of 86
The role of mammalian target of Rapamycin inhibitors in the management of post‐transplant malignancy
Differences in Mammalian target of Rapamycin gene expression in the peripheral blood and articular cartilages of osteoarthritic patients and disease activity
Proteasome-dependent activation of mammalian target of Rapamycin complex 1 (mTORC1) is essential for autophagy suppression and muscle remodeling …
Current models of mammalian target of Rapamycin complex 1 (mTORC1) activation by growth factors and amino acids
microRNA‑199a is able to reverse cisplatin resistance in human ovarian cancer cells through the inhibition of mammalian target of Rapamycin
RhoA modulates signaling through the mechanistic target of Rapamycin complex 1 (mTORC1) in mammalian cells
Rapamycin inhibition of polyposis and progression to dysplasia in a mouse model
The immunosuppressive agents Rapamycin, cyclosporin A and tacrolimus increase lipolysis, inhibit lipid storage and alter expression of genes involved in lipid …
Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of Rapamycin) by IκB kinase α (IKKα)
Differential effects of Rapamycin and dexamethasone in mouse models of established allergic asthma
Antitumor effects of Rapamycin in pancreatic cancer cells by inducing apoptosis and autophagy
Rapamycin and omega‐1: mTOR‐dependent and‐independent Th2 skewing by human dendritic cells
Rapamycin inhibits FBXW7 loss-induced epithelial–mesenchymal transition and cancer stem cell-like characteristics in colorectal cancer cells
Rapamycin resistance: mTORC1 substrates hold some of the answers
Mammalian target of Rapamycin regulates IL-10 and resistance to Pseudomonas aeruginosa corneal infection
Prolonged Rapamycin treatment led to beneficial metabolic switch
Blockade of mTOR signaling via Rapamycin combined with immunotherapy augments antiglioma cytotoxic and memory T-cell functions
Ribosomal protein S6, a target of Rapamycin, is involved in the regulation of rRNA genes by possible epigenetic changes in Arabidopsis
PML mediates glioblastoma resistance to mammalian target of Rapamycin (mTOR)-targeted therapies
Rapamycin inhibits ALDH activity, resistance to oxidative stress, and metastatic potential in murine osteosarcoma cells
TGF-β/Smad3 activates mammalian target of Rapamycin complex-1 to promote collagen production by increasing HIF-1α expression
Successful treatment of subungual fibromas of tuberous sclerosis with topical Rapamycin
Laser phototherapy accelerates oral keratinocyte migration through the modulation of the mammalian target of Rapamycin signaling pathway
PPARγ activation attenuates glucose intolerance induced by mTOR inhibition with Rapamycin in rats
Activation of mammalian target of Rapamycin signaling in skeletal muscle of neonatal chicks: Effects of dietary leucine and age
Single Rapamycin administration induces prolonged downward shift in defended body weight in rats
Comparison of Rapamycin schedules in mice on high-fat diet
Inhalable Particles Containing Rapamycin for Induction of Autophagy in Macrophages Infected with Mycobacterium tuberculosis
SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of Rapamycin signaling
Protein phosphatase 2A and DNA-dependent protein kinase are involved in mediating Rapamycin-induced Akt phosphorylation
Cross-talk between sirtuin and mammalian target of Rapamycin complex 1 (mTORC1) signaling in the regulation of S6 kinase 1 (S6K1) phosphorylation
A novel topical Rapamycin cream for the treatment of facial angiofibromas in tuberous sclerosis complex
Rapamycin inhibits the production of myofibroblasts and reduces corneal scarring after photorefractive keratectomy
Fluorescence tomography of Rapamycin-induced autophagy and cardioprotection in vivo
Rapamycin enhances eIF4E phosphorylation by activating MAP kinase-interacting kinase 2a (Mnk2a)
Mechanistic target of Rapamycin (mTOR): a point of convergence in the action of insulin/IGF-1 and G protein-coupled receptor agonists in pancreatic cancer …
Targeting the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of Rapamycin (mTOR) pathway: an emerging treatment strategy for squamous cell lung …
Bone effects of mammalian target of Rapamycin (mTOR) inhibition with everolimus
Rapamycin increases mitochondrial efficiency by mtDNA-dependent reprogramming of mitochondrial metabolism in Drosophila
A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and Rapamycin
inhibition of mammalian target of Rapamycin improves neurobehavioral deficit and modulates immune response after intracerebral hemorrhage in rat
Resveratrol prevents Rapamycin-induced upregulation of autophagy and selectively induces apoptosis in TSC2-deficient cells
Combined SFK/mTOR inhibition prevents Rapamycin-induced feedback activation of AKT and elicits efficient tumor regression
Topical Rapamycin as a treatment for fibrofolliculomas in Birt-Hogg-Dubé syndrome: a double-blind placebo-controlled randomized split-face trial
Mammalian target of Rapamycin cell signaling pathway contributes to the protective effects of ischemic postconditioning against stroke
Combination of autophagy inducer Rapamycin and oncolytic adenovirus improves antitumor effect in cancer cells
Effects of AMP-activated protein kinase (AMPK) signaling and essential amino acids on mammalian target of Rapamycin (mTOR) signaling and protein …
Chemical injury-induced corneal opacity and neovascularization reduced by Rapamycin via TGF-β1/ERK pathways regulation
Comparative metabolic profiling-based improvement of Rapamycin production by Streptomyces hygroscopicus
Anti-remodeling effects of Rapamycin in experimental heart failure: dose response and interaction with angiotensin receptor blockade
Treating brain tumor–initiating cells using a combination of myxoma virus and Rapamycin
Superiority of Rapamycin over tacrolimus in preserving nonhuman primate Treg half‐life and phenotype after adoptive transfer
Anti-angiogenic effects of mammalian target of Rapamycin inhibitors in a mouse model of oxygen-induced retinopathy
Topical Rapamycin (sirolimus) for facial angiofibromas
Mammalian target of Rapamycin signaling is involved in the vasculogenic mimicry of glioma via hypoxia-inducible factor-1α
Systemic inhibition of mTOR kinase via Rapamycin disrupts consolidation and reconsolidation of auditory fear memory
The antiaging activity and cerebral protection of Rapamycin at micro‐doses
Rapamycin decreases DNA damage accumulation and enhances cell growth of WRN‐deficient human fibroblasts
Acute Rapamycin treatment improved glucose tolerance through inhibition of hepatic gluconeogenesis in rainbow trout (Oncorhynchus mykiss)
Amino acids activate mammalian target of Rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging
Mammalian target of Rapamycin complex 2 (mTORC2) is a critical determinant of bladder cancer invasion
The general control nonderepressible‐2 kinase mediates stress response and longevity induced by target of Rapamycin inactivation in Caenorhabditis elegans
The incidence, management, and evolution of Rapamycin‐related side effects in kidney transplant recipients
Discovery of a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of Rapamycin (mTOR)
Comparative Study of Rapamycin and Temsirolimus Demonstrates Superimposable Anti‐Tumour Potency on Prostate Cancer Cells
Rapamycin ameliorates inflammation and fibrosis in the early phase of cirrhotic portal hypertension in rats through inhibition of mTORC1 but not mTORC2
Behavioural and EEG effects of chronic Rapamycin treatment in a mouse model of tuberous sclerosis complex
The mammalian target of Rapamycin signalling pathway is involved in osteoblastic differentiation of vascular smooth muscle cells
Subcellular distribution and activity of mechanistic target of Rapamycin in aged retinal pigment epithelium
LY294002 and Rapamycin promote coxsackievirus-induced cytopathic effect and apoptosis via inhibition of PI3K/AKT/mTOR signaling pathway
inhibition of mammalian target of Rapamycin aggravates the respiratory burst defect of neutrophils from decompensated patients with cirrhosis
Mammalian target of Rapamycin (mTOR) activation in focal cortical dysplasia and related focal cortical malformations
Rapamycin attenuates bleomycin-induced pulmonary fibrosis in rats and the expression of metalloproteinase-9 and tissue inhibitors of metalloproteinase-1 in lung …
Mammalian target of Rapamycin and Rictor control neutrophil chemotaxis by regulating Rac/Cdc42 activity and the actin cytoskeleton
Combined mTOR inhibitor Rapamycin and doxorubicin-loaded cyclic octapeptide modified liposomes for targeting integrin α3 in triple-negative breast cancer
Phosphorylated mammalian target of Rapamycin is associated with an adverse outcome in oral squamous cell carcinoma
Rapamycin alleviates brain edema after focal cerebral ischemia reperfusion in rats
Alternative mammalian target of Rapamycin (mTOR) signal activation in sorafenib-resistant hepatocellular carcinoma cells revealed by array-based pathway …
… resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of Rapamycin, protein kinase B, or …
Mammalian target of Rapamycin inhibition and mycobacterial survival are uncoupled in murine macrophages
Transcriptional profiling of Rapamycin-treated fibroblasts from hypertrophic and keloid scars
p53/TAp63 and AKT regulate mammalian target of Rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of …
Young and old genetically heterogeneous HET 3 mice on a Rapamycin diet are glucose intolerant but insulin sensitive
Rapamycin induces mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) expression through activation of protein kinase B and mitogen-activated …
Rapamycin-mediated CD36 translational suppression contributes to alleviation of hepatic steatosis
Pan-mammalian target of Rapamycin (mTOR) inhibitor AZD8055 primes rhabdomyosarcoma cells for ABT-737-induced apoptosis by down-regulating Mcl-1 …
Rapamycin treatment of Mandibuloacral dysplasia cells rescues localization of chromatin-associated proteins and cell cycle dynamics
Chemical inhibitors and microRNAs (miRNA) targeting the mammalian target of Rapamycin (mTOR) pathway: potential for novel anticancer therapeutics
… characterization of mTOR kinase activity following kainic acid induced status epilepticus and analysis of rat brain response to chronic Rapamycin treatment
Impairing the production of ribosomal RNA activates mammalian target of Rapamycin complex 1 signalling and downstream translation factors
inhibition of the mammalian target of Rapamycin leads to autophagy activation and cell death of MG63 osteosarcoma cells
Rapamycin-induced autophagy aggravates pathology and weakness in a mouse model of VCP-associated myopathy
Requirement of B7-H1 in mesenchymal stem cells for immune tolerance to cardiac allografts in combination therapy with Rapamycin
Mammalian target of Rapamycin (mTOR) inhibitor‐associated non‐infectious pneumonitis in patients with renal cell cancer: predictors, management, and …
Systematic combination screening reveals synergism between Rapamycin and sunitinib against human lung cancer
Rapamycin has suppressive and stimulatory effects on human plasmacytoid dendritic cell functions
Vascular tumors have increased p70 S6-kinase activation and are inhibited by topical Rapamycin
West nile virus-induced activation of mammalian target of Rapamycin complex 1 supports viral growth and viral protein expression
Rapamycin Augments Human DC IL‐12p70 and IL‐27 Secretion to Promote Allogeneic Type1 Polarization Modulated by NK Cells
Rapamycin inhibits smooth muscle cell proliferation and obstructive arteriopathy attributable to elastin deficiency
Resveratrol potentiates Rapamycin to prevent hyperinsulinemia and obesity in male mice on high fat diet
The Mammalian target of Rapamycin inhibitors in breast cancer: current evidence and future directions
Disruption of an hTERT–mTOR–RAPTOR protein complex by a phytochemical perillyl alcohol and Rapamycin
Clinical impacts of mammalian target of Rapamycin expression in human colorectal cancers
The mTOR inhibitor Rapamycin synergizes with a fatty acid synthase inhibitor to induce cytotoxicity in ER/HER2-positive breast cancer cells
Treatment of angiofibromas in tuberous sclerosis complex: the effect of topical Rapamycin and concomitant laser therapy
Mammalian target of Rapamycin-independent S6K1 and 4E-BP1 phosphorylation during contraction in rat skeletal muscle
Rapamycin in preventive (very low) doses
Dual inhibitor of phosphoinositide 3-kinase/mammalian target of Rapamycin NVP-BEZ235 effectively inhibits cisplatin-resistant urothelial cancer cell growth through …
Administration of low doses of IL‐2 combined to Rapamycin promotes allogeneic skin graft survival in mice
Incidence and risk of treatment-related mortality in cancer patients treated with the mammalian target of Rapamycin inhibitors
Rapamycin slows IgA nephropathy progression in the rat
Rapamycin inhibits transforming growth factor β1-induced fibrogenesis in primary human lung fibroblasts
Murine dendritic cell Rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction
Mutant ras elevates dependence on serum lipids and creates a synthetic lethality for Rapamycin
… (Astyanax fasciatus mexicanus): effects on feeding and on the brain expression levels of tyrosine hydroxylase, mechanistic target of Rapamycin and appetite-related …
Concurrent inhibition of PI3K and mTORC1/mTORC2 overcomes resistance to Rapamycin induced apoptosis by down‐regulation of Mcl‐1 in mantle cell lymphoma
The effects of Rapamycin on regulatory T cells: its potential time-dependent role in inducing transplant tolerance
Combination of Rapamycin, CI-1040, and 17-AAG inhibits metastatic capacity of prostate cancer via Slug inhibition
Mammalian target of Rapamycin inhibitors induce tumor cell apoptosis in vivo primarily by inhibiting VEGF expression and angiogenesis
Rapamycin reduces burn wound progression by enhancing autophagy in deep second‐degree burn in rats
… matrix-modulated Heartless signaling in Drosophila blood progenitors regulates their differentiation via a Ras/ETS/FOG pathway and target of Rapamycin …
Rapamycin induces autophagy in the melanoma cell line M14 via regulation of the expression levels of Bcl‑2 and Bax
A phase I study of decitabine and Rapamycin in relapsed/refractory AML
… amino acid sensing controls adult germline stem cell number via the amino acid response pathway and independently of Target of Rapamycin signaling in Drosophila
… -type CD8+ T cells correlates with the failure of early immunosuppression withdrawal after cadaver liver transplantation using high-dose ATG induction and Rapamycin
Palmitate induces mRNA translation and increases ER protein load in islet β-cells via activation of the mammalian target of Rapamycin pathway
Rapamycin targeting mTOR and hedgehog signaling pathways blocks human rhabdomyosarcoma growth in xenograft murine model
Increasing leucine concentration stimulates mechanistic target of Rapamycin signaling and cell growth in C2C12 skeletal muscle cells
Characterization and pharmacokinetic analysis of crystalline versus amorphous Rapamycin dry powder via pulmonary administration in rats
Olanzapine activates hepatic mammalian target of Rapamycin: new mechanistic insight into metabolic dysregulation with atypical antipsychotic drugs
Environmental signaling through the mechanistic target of Rapamycin complex 1: mTORC1 goes nuclear
Mammalian target of Rapamycin signaling activation patterns in pancreatic neuroendocrine tumors
A novel Rapamycin-polymer conjugate based on a new poly (ethylene glycol) multiblock copolymer
Mechanical activation of mammalian target of Rapamycin pathway is required for cartilage development
Rapamycin inhibits oxidative and angiogenic mediators in diabetic retinopathy
The mTOR inhibitor Rapamycin opposes carcinogenic changes to epidermal Akt1/PKBα isoform signaling
Target of Rapamycin (TOR) kinase in Trypanosoma brucei: an extended family
Crystalline coating of Rapamycin onto a stent: Process development and characterization
Equivalent benefit of Rapamycin and a potent mTOR ATP-competitive inhibitor, MLN0128 (INK128), in a mouse model of tuberous sclerosis
Berberine sensitizes Rapamycin‑mediated human hepatoma cell death in vitro
Regulation of blood–testis barrier (BTB) dynamics during spermatogenesis via the “Yin” and “Yang” effects of mammalian target of Rapamycin complex 1 (mTORC1) …
Topical Rapamycin systematically suppresses the early stages of pulsed dye laser‐induced angiogenesis pathways
Studies on process optimization methods for Rapamycin production using Streptomyces hygroscopicus ATCC 29253
Mammalian target of Rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC …
Branched-chain amino acids enhance premature senescence through mammalian target of Rapamycin complex I-mediated upregulation of p21 protein
Effects of the immunosuppressant Rapamycin on the expression of human α2 (I) collagen and matrix metalloproteinase 1 genes in scleroderma dermal fibroblasts
Cumulative number of altered biomarkers in mammalian target of Rapamycin pathway is an independent predictor of outcome in patients with clear cell renal cell …
Mammalian target of Rapamycin complex 1 activation negatively regulates Polo-like kinase 2-mediated homeostatic compensation following neonatal seizures
Chemical genetics of Rapamycin-insensitive TORC2 in S. cerevisiae
Rapamycin promoted thrombosis and platelet adhesion to endothelial cells by inducing membrane remodeling
Relative resistance to mammalian target of Rapamycin inhibition in vascular smooth muscle cells of diabetic donors
AMP‐activated protein kinase counteracts brain‐derived neurotrophic factor‐induced mammalian target of Rapamycin complex 1 signaling in neurons
YM155 reverses Rapamycin resistance in renal cancer by decreasing survivin
β-hydroxy-β-methylbutyrate facilitates pi3k/akt-dependent mammalian target of Rapamycin and foxo1/3a phosphorylations and alleviates tumor necrosis factor α …
Mechanistic target of Rapamycin complex 1 (mTORC1)-mediated phosphorylation is governed by competition between substrates for interaction with raptor
CD44-tropic polymeric nanocarrier for breast cancer targeted Rapamycin chemotherapy
Mechanistic target of Rapamycin complex 1 signaling regulates cell proliferation, cell survival, and differentiation in regenerating zebrafish fins
Bidirectional regulation of nuclear factor-κB and mammalian target of Rapamycin signaling functionally links Bnip3 gene repression and cell survival of ventricular …
Kinetics of Rapamycin production by Streptomyces hygroscopicus MTCC 4003
Growth differentiation factor 15 stimulates Rapamycin-sensitive ovarian cancer cell growth and invasion
Carrier free Rapamycin loaded drug eluting stent: in vitro and in vivo evaluation
Exome sequencing reveals de novo germline mutation of the mammalian target of Rapamycin (mTOR) in a patient with megalencephaly and intractable seizures
Pharmacophore modeling, homology modeling, and in silico screening reveal mammalian target of Rapamycin inhibitory activities for sotalol, glyburide, metipranolol …
Uth1 is a mitochondrial inner membrane protein dispensable for post‐log‐phase and Rapamycin‐induced mitophagy
Requirement of Mammalian target of Rapamycin complex 1 downstream effectors in cued fear memory reconsolidation and its persistence
Rapamycin enhances HBV production by inducing cellular autophagy
Rapamycin-induced modulation of HIV gene transcription attenuates progression of HIVAN
Improvement of the antiproliferative effect of Rapamycin on tumor cell lines by poly (monomethylitaconate)-based pH-sensitive, plasma stable liposomes
Mammalian target of Rapamycin inhibitors resistance mechanisms in clear cell renal cell carcinoma
A novel semisynthetic inhibitor of the FRB domain of mammalian target of Rapamycin blocks proliferation and triggers apoptosis in chemoresistant prostate cancer cells
Mammalian target of Rapamycin is essential for cardiomyocyte survival and heart development in mice
Dysregulation of mammalian target of Rapamycin pathway in upper tract urothelial carcinoma
… of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of Rapamycin activity in the …
A Rapamycin-releasing perivascular polymeric sheath produces highly effective inhibition of intimal hyperplasia
MNK kinases facilitate c-myc IRES activity in Rapamycin-treated multiple myeloma cells
Hyperactivation of mammalian target of Rapamycin complex 1 (mTORC1) promotes breast cancer progression through enhancing glucose starvation-induced …
Rapamycin induces pluripotent genes associated with avoidance of replicative senescence
Electrospun Rapamycin-eluting polyurethane fibers for vascular grafts
Rapamycin attenuated cardiac hypertrophy induced by isoproterenol and maintained energy homeostasis via inhibiting NF-κB activation
Blockade of epidermal growth factor receptor/mammalian target of Rapamycin pathway by Icariside II results in reduced cell proliferation of osteosarcoma cells
Rheb (Ras homologue enriched in brain)-dependent mammalian target of Rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac …
Loss of the repressor REST in uterine fibroids promotes aberrant G protein-coupled receptor 10 expression and activates mammalian target of Rapamycin pathway
Rapamycin inhibits acrolein‐induced apoptosis by alleviating ROS‐driven mitochondrial dysfunction in male germ cells
Low concentration of Rapamycin inhibits hemangioma endothelial cell proliferation, migration, and vascular tumor formation in mice
Mammalian target of Rapamycin complex 1 (m TORC 1) may modulate the timing of anagen entry in mouse hair follicles
Chronic Rapamycin treatment or lack of S6K1 does not reduce ribosome activity in vivo
Rheb activation in subventricular zone progenitors leads to heterotopia, ectopic neuronal differentiation, and Rapamycin-sensitive olfactory micronodules and dendrite …
MicroRNA-21 mediates the Rapamycin-induced suppression of endothelial proliferation and migration
Rapamycin modulates markers of mitochondrial biogenesis and fatty acid oxidation in the adipose tissue of db/db mice
Role of GAS5 noncoding RNA in mediating the effects of Rapamycin and its analogues on mantle cell lymphoma cells
Inhibitory effect of paclitaxel and Rapamycin individual and dual drug-loaded polymeric micelles in the angiogenic cascade
Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer
Eukaryotic Initiation Factor 2α-a Downstream Effector of Mammalian Target of Rapamycin-Modulates DNA Repair and Cancer Response to Treatment
Production of Rapamycin in Streptomyces hygroscopicus from glycerol-based media optimized by systemic methodology
Rapamycin improves peripheral nerve myelination while it fails to benefit neuromuscular performance in neuropathic mice
Neuronal-specific iron deficiency dysregulates mammalian target of Rapamycin signaling during hippocampal development in nonanemic genetic mouse models
Targeted inhibition of mammalian target of Rapamycin (mTOR) enhances radiosensitivity in pancreatic carcinoma cells
The role of mammalian target of Rapamycin (mTOR) inhibition in the treatment of advanced breast cancer
Anorexigenic and orexigenic hormone modulation of mammalian target of Rapamycin complex 1 activity and the regulation of hypothalamic agouti-related protein …
Rapamycin inhibits BMP‐7‐induced osteogenic and lipogenic marker expressions in fetal rat calvarial cells
Over-expression of phosphorylated mammalian target of Rapamycin is associated with poor survival in oesophageal adenocarcinoma: a tissue microarray study
Rapamycin prolongs female reproductive lifespan
Mechanistic target of Rapamycin (mTOR) signaling genes in decapod crustaceans: cloning and tissue expression of mTOR, Akt, Rheb, and p70 S6 kinase in the green …
Relevance of the mammalian target of Rapamycin pathway in the prognosis of patients with high-risk non–muscle invasive bladder cancer
Spatiotemporal control of vascular endothelial growth factor expression using a heat-shock-activated, Rapamycin-dependent gene switch
Rapamycin‐sensitive mTORC1 signaling is involved in physiological primordial follicle activation in mouse ovary
TORC 1 signaling inhibition by Rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast
Risk of infections in renal cell carcinoma (RCC) and non-RCC patients treated with mammalian target of Rapamycin inhibitors
microRNA regulation of mammalian target of Rapamycin expression and activity controls estrogen receptor function and RAD001 sensitivity
gln3 mutations dissociate responses to nitrogen limitation (nitrogen catabolite repression) and Rapamycin inhibition of TorC1
Next generation of mammalian target of Rapamycin inhibitors for the treatment of cancer
Mammalian target of Rapamycin in inflammatory skin conditions
Alterations in the Ure2 αCap domain elicit different GATA factor responses to Rapamycin treatment and nitrogen limitation
PI3Kδ inhibition augments the efficacy of Rapamycin in suppressing proliferation of Epstein− Barr virus (EBV)+ B cell lymphomas
Accumulation of dephosphorylated 4EBP after mTOR inhibition with Rapamycin is sufficient to disrupt paracrine transformation by the KSHV vGPCR oncogene
inhibition of Rapamycin-induced AKT activation elicits differential antitumor response in head and neck cancers
Rapamycin regulates connective tissue growth factor expression of lung epithelial cells via phosphoinositide 3-kinase
Mis-regulation of mammalian target of Rapamycin (mTOR) complexes induced by albuminuria in proximal tubules
Morphoproteomic profiling of the mammalian target of Rapamycin (mTOR) signaling pathway in desmoplastic small round cell tumor (EWS/WT1), Ewing’s …
The search continues: looking for predictive biomarkers for response to mammalian target of Rapamycin inhibition in endometrial cancer
Rapamycin protects against Aβ-induced synaptotoxicity by increasing presynaptic activity in hippocampal neurons
Expression of budding yeast FKBP12 confers Rapamycin susceptibility to the unicellular red alga Cyanidioschyzon merolae
Rapamycin-Induced apoptosis in HGF-stimulated lens epithelial cells by AKT/mTOR, ERK and JAK2/STAT3 pathways
Breast cancer tissue slices as a model for evaluation of response to Rapamycin
Metformin and Rapamycin are master-keys for understanding the relationship between cell senescent, aging and cancer
GSK3β, but not GSK3α, inhibits the neuronal differentiation of neural progenitor cells as a downstream target of mammalian target of Rapamycin complex1
Rapamycin‐loaded poly (ε‐caprolactone)‐poly (ethylene glycol)‐poly (ε‐caprolactone) nanoparticles: preparation, characterization and potential application in …
Branched chain amino acid suppresses hepatocellular cancer stem cells through the activation of mammalian target of Rapamycin
Pyrimidoaminotropanes as potent, selective, and efficacious small molecule kinase inhibitors of the mammalian target of Rapamycin (mTOR)
Role of mammalian target of Rapamycin inhibitor in the treatment of metastatic epithelioid angiomyolipoma: A case report
Dual phosphoinositide 3-kinase/mammalian target of Rapamycin inhibitor NVP-BEZ235 has a therapeutic potential and sensitizes cisplatin in nasopharyngeal …
inhibition of mammalian target of Rapamycin signaling pathway decreases retinoic acid stimulated gene 8 expression in adult mouse testis
Role of the mammalian target of Rapamycin (mTOR) complexes in pancreatic β-cell mass regulation
Rapamycin promotes Schwann cell migration and nerve growth factor secretion
Arsenic trioxide overcomes Rapamycin-induced feedback activation of AKT and ERK signaling to enhance the anti-tumor effects in breast cancer
Metformin impairs vascular endothelial recovery after stent placement in the setting of locally eluted mammalian target of Rapamycin inhibitors via S6 kinase …
Phase I/IIa trial of the mammalian target of Rapamycin inhibitor ridaforolimus (AP23573; MK-8669) administered orally in patients with refractory or advanced …
Phosphoinositide-3 kinase/protein kinase-B/mammalian target of Rapamycin pathway in psoriasis pathogenesis. A potential therapeutic target?
SOX 2 promotes tumor growth of esophageal squamous cell carcinoma through the AKT/mammalian target of Rapamycin complex 1 signaling pathway
… proliferation by negatively regulating phosphodiesterase-4, extracellular signal-regulated kinase, Akt/mammalian target of Rapamycin kinase, and nuclear factor …
Endocrine resistance in breast cancer: focus on the phosphatidylinositol 3-kinase/akt/mammalian target of Rapamycin signaling pathway
Autoimmune pancreatitis in MRL/Mp mice is a T cell-mediated disease responsive to cyclosporine A and Rapamycin treatment
Rapamycin does not affect post-absorptive protein metabolism in human skeletal muscle
Comparative effects of PP242 and Rapamycin on mTOR signalling and NOTCH signalling in leukemia cells
Rapamycin attenuates endothelial apoptosis induced by low shear stress via mTOR and sestrin1 related redox regulation
Mammalian target of Rapamycin inhibitor Rapamycin enhances anti‐leukemia effect of imatinib on P h+ acute lymphoblastic leukemia cells
… synthesis in response to exogenous growth hormone is associated with changes in mechanistic (mammalian) target of Rapamycin (mTOR) C1-dependent and …
Mammalian target of Rapamycin complex 1 and cyclooxygenase 2 pathways cooperatively exacerbate endometrial cancer
A phase I trial of sunitinib and Rapamycin in patients with advanced non-small cell lung cancer
Autoregulation of the mechanistic target of Rapamycin (mTOR) complex 2 integrity is controlled by an ATP-dependent mechanism
Dysregulation of the mammalian target of Rapamycin and p27Kip1 promotes intimal hyperplasia in diabetes mellitus
Ferulic acid induces mammalian target of Rapamycin inactivation in cultured mammalian cells
Rapamycin ameliorates neuropathic pain by activating autophagy and inhibiting interleukin-1β in the rat spinal cord
Staurosporine induces dopaminergic neurite outgrowth through AMP-activated protein kinase/mammalian target of Rapamycin signaling pathway
Osteolysis and pain due to experimental bone metastases are improved by treatment with Rapamycin
Effect of Rapamycin and interleukin-2 on regulatory CD4+ CD25+ Foxp3+ T cells in mice after allogenic corneal transplantation
The mechanistic target for Rapamycin pathway is related to the phosphorylation score for estrogen receptor-α in human breast tumors in vivo
Trilayer micelles for combination delivery of Rapamycin and siRNA targeting Y-box binding protein-1 (siYB-1)
Over‐expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by Rapamycin and is sufficient to ameliorate Alzheimer’s‐like deficits in mice …
Role of energy‐and nutrient‐sensing kinases AMP‐activated Protein Kinase (AMPK) and Mammalian Target of Rapamycin (mTOR) in Adipocyte Differentiation
Rapamycin ameliorates nephropathy despite elevating hyperglycemia in a polygenic mouse model of type 2 diabetes, NONcNZO10/LtJ
Rapamycin together with TGF-β1, IL-2 and IL-15 induces the generation of functional regulatory γδT cells from human peripheral blood mononuclear cells
Analysis of Rapamycin induced autophagy in Dictyostelium discoideum
Role of inhibitors of mammalian target of Rapamycin in the treatment of luminal breast cancer
Ptc6 is required for proper Rapamycin-induced down-regulation of the genes coding for ribosomal and rRNA processing proteins in S. cerevisiae
Evaluation of the prognostic significance of altered mammalian target of Rapamycin pathway biomarkers in upper tract urothelial carcinoma
Rapamycin induces apoptosis when autophagy is inhibited in T-47D mammary cells and both processes are regulated by Phlda1
p38α senses environmental stress to control innate immune responses via mechanistic target of Rapamycin
Rapamycin prevents the development and progression of mutant epidermal growth factor receptor lung tumors with the acquired resistance mutation T790M
Rapamycin regulates iTreg function through CD39 and Runx1 pathways
Rapamycin inhibits both motility through down-regulation of p-STAT3 (S727) by disrupting the mTORC2 assembly and peritoneal dissemination in sarcomatoid …
Mammalian target of Rapamycin complex 2 modulates αβTCR processing and surface expression during thymocyte development
Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of Rapamycin complex 1 (mTORC1) in mice and zebrafish
Metabolomic evaluation of Mitomycin C and Rapamycin in a personalized treatment of pancreatic cancer
Rapamycin treatment of healthy pigs subjected to acute myocardial ischemia-reperfusion injury attenuates cardiac functions and increases myocardial necrosis
Comparison of posterior capsule opacification in rabbit eyes receiving different administrations of Rapamycin
Mammalian tribbles homologs at the crossroads of endoplasmic reticulum stress and mammalian target of Rapamycin pathways
Inhibitory effects of Rapamycin on the different stages of hepatic fibrosis
Regulation of mammalian target of Rapamycin complex 1 by Bcl-2 and Bcl-XL proteins
Transforming growth factor β integrates Smad 3 to mechanistic target of Rapamycin complexes to arrest deptor abundance for glomerular mesangial cell …
Genetic interactions between protein phosphatases CaPtc2p and CaPph3p in response to genotoxins and Rapamycin in Candida albicans
Syntaxin13 expression is regulated by mammalian target of Rapamycin (mTOR) in injured neurons to promote axon regeneration
Combination of cetuximab and Rapamycin enhances the therapeutic efficacy in hepatocellular carcinoma
Oedema, solid organ transplantation and mammalian target of Rapamycin inhibitor/proliferation signal inhibitors (mTOR-I/PSIs)
Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of Rapamycin
Rapamycin is less fibrogenic than Cyclosporin A as demonstrated in a rat model of chronic allograft nephropathy
Pharmacodynamic and antineoplastic activity of BI 836845, a fully human IGF ligand-neutralizing antibody, and mechanistic rationale for combination with Rapamycin
Effects of dissolved oxygen level on Rapamycin production by pellet-form of Streptomyces hygroscopicus
Mammalian target of Rapamycin inhibitors permit regulatory T cell reconstitution and inhibit experimental chronic graft-versus-host disease
… factor‐1α/vascular endothelial growth factor expression via inhibiting phosphatidylinositol 3‐kinase/Akt/mammalian target protein of Rapamycin pathway in multiple …
… increase the phosphorylation of tuberous sclerosis complex‐2 (TSC2) and alter the targeting of TSC2 and the mechanistic target of Rapamycin to the lysosome
… transporter-1 in vascular smooth muscle cells via the Akt/tuberous sclerosis complex subunit 2 (TSC2)/mammalian target of Rapamycin (mTOR)/ribosomal S6 …
Rapamycin attenuates bladder hypertrophy during long-term outlet obstruction in vivo: tissue, matrix and mechanistic insights
Rapamycin delays salivary gland atrophy following ductal ligation
Mechanistic target of Rapamycin in common carp: cDNA cloning, characterization, and tissue expression
Rapamycin inhibits pre-B acute lymphoblastic leukemia cells by downregulating DNA and RNA polymerases
… -associated protein/microtubule affinity-regulating kinase 4 (MARK4) is a negative regulator of the mammalian target of Rapamycin complex 1 (mTORC1)
Rapamycin regulates biochemical metabolites
Mammalian target of Rapamycin (mTOR) activity dependent phospho-protein expression in childhood acute lymphoblastic leukemia (ALL)
The roles of juvenile hormone, insulin/target of Rapamycin, and ecydsone signaling in regulating body size in Drosophila
… 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of Rapamycin in complex 1 (mTORC1)
Rapamycin blocks fibrocyte migration and attenuates bronchiolitis obliterans in a murine model
Myxoid liposarcoma and the mammalian target of Rapamycin pathway
… protein 2A promotes the epithelial-mesenchymal transition in nasopharyngeal carcinoma via metastatic tumor antigen 1 and mechanistic target of Rapamycin …
Rapamycin reduces renal hypoxia, interstitial inflammation and fibrosis in a rat model of unilateral ureteral obstruction
Rapamycin-induced modulation of miRNA expression is associated with amelioration of HIV-associated nephropathy (HIVAN)
Interferon alpha and Rapamycin inhibit the growth of pheochromocytoma PC12 line in vitro
Mammalian target of Rapamycin complex 1 activation in podocytes promotes cellular crescent formation
Rapamycin prevents strong phosphorylation of p53 on serine 46 and attenuates activation of the p53 pathway in A549 lung cancer cells exposed to actinomycin D
… triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of Rapamycin and glycogen synthase …
Role of phosphatidylinositol-3-kinase (PI3K) and the mammalian target of Rapamycin (mTOR) signalling pathways in porcine reproductive and respiratory syndrome …
Beclin 1 is required for starvation-enhanced, but not Rapamycin-enhanced, LC3-associated phagocytosis of Burkholderia pseudomallei in RAW 264.7 cells
Gingipain‐dependent degradation of mammalian target of Rapamycin pathway proteins by the periodontal pathogen Porphyromonas gingivalis during invasion
It may be possible to delay the onset of neurodegenerative diseases with an immunosuppressive drug (Rapamycin)
Suppression of AKT phosphorylation restores Rapamycin-based synthetic lethality in SMAD4-defective pancreatic cancer cells
Rapamycin protects kidney against ischemia reperfusion injury through recruitment of NKT cells
Effects of combined administration of Rapamycin, tolvaptan, and AEZ-131 on the progression of polycystic disease in PCK rats
Divergent tissue and sex effects of Rapamycin on the proteasome-chaperone network of old mice
Immunohistochemical expression of the mammalian target of Rapamycin pathway in penile squamous cell carcinomas: a tissue microarray study of 112 cases
Metabolic effects of acute thiamine depletion are reversed by Rapamycin in breast and leukemia cells
Mechanistic target of Rapamycin (mTOR) signaling during ovulation in mice
Polycystin-1 but not polycystin-2 deficiency causes upregulation of the mTOR pathway and can be synergistically targeted with Rapamycin and metformin
Resveratrol inhibits the phosphatidylinositide 3‑kinase/protein kinase B/mammalian target of Rapamycin signaling pathway in the human chronic myeloid …
mTOR activation in immature cells of primary nasopharyngeal carcinoma and anti-tumor effect of Rapamycin in vitro and in vivo
inhibition of mTOR kinase via Rapamycin blocks persistent predator stress-induced hyperarousal
All‐trans retinoic acid and Rapamycin synergize with transforming growth factor‐β1 to induce regulatory T cells but confer different migratory capacities
Activation of mammalian target of Rapamycin contributes to pain nociception induced in rats by BmK I, a sodium channel-specific modulator
Long-term treatment with mammalian target of Rapamycin inhibitor does not benefit patients with autosomal dominant polycystic kidney disease: a meta-analysis
Mammalian target of Rapamycin pathway is up-regulated by both acute endurance exercise and chronic muscle contraction in rat skeletal muscle
Differential regulation of carbon partitioning by the central growth regulator target of Rapamycin (TOR)
Granulocyte macrophage colony‐stimulating factor promotes regeneration of retinal ganglion cells in vitro through a mammalian target of Rapamycin‐dependent …
Regulation of insulin receptor substrate-1 by mTORC2 (mammalian target of Rapamycin complex 2)
Effects of breed and dietary nutrient density on the growth performance, blood metabolite, and genes expression of target of Rapamycin (TOR) signalling pathway of …
Rapamycin inhibits IGF-1-mediated up-regulation of MDM2 and sensitizes cancer cells to chemotherapy
Rapamycin interacts synergistically with idarubicin to induce T-leukemia cell apoptosis in vitro and in a mesenchymal stem cell simulated drug-resistant …
Labor inhibits placental mechanistic target of Rapamycin complex 1 signaling
Increased mammalian target of Rapamycin complex 2 signaling promotes age-related decline in CD4 T cell signaling and function
Rapamycin sensitizes glucocorticoid resistant acute lymphoblastic leukemia CEM-C1 cells to dexamethasone induced apoptosis through both mTOR suppression and …
Low-dose Rapamycin unmasks the protective potential of targeting intragraft NF-κB for islet transplants
Familial multiple discoid fibromas: unique histological features and therapeutic response to topical Rapamycin
Expression of molecular markers associated with the mammalian target of Rapamycin pathway in nonmetastatic renal cell carcinoma: Effect on prognostic outcomes …
Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of Rapamycin (mTOR)
Adventitial nab-Rapamycin injection reduces porcine femoral artery luminal stenosis induced by balloon angioplasty via inhibition of medial proliferation and adventitial …
… pathogenic T cells and interferes with their trafficking to the central nervous system, implicating sphingosine-1 phosphate receptor 1–mammalian target of Rapamycin …
A reversed phase high performance liquid chromatographic method for determination of Rapamycin
Effects of limiting energy availability via diet and physical activity on mammalian target of Rapamycin-related signaling in rat mammary carcinomas
Pentoxifylline and propentofylline prevent proliferation and activation of the mammalian target of Rapamycin and mitogen activated protein kinase in cultured spinal …
Activation of mammalian target of Rapamycin complex 1 (mTORC1) and Raf/Pyk2 by growth factor‐mediated Eph receptor 2 (EphA2) is required for …
Rapamycin‐resistant effector T‐cell therapy
Activation of the Akt/mammalian target of Rapamycin pathway in myxofibrosarcomas
Confirmation of the cellular targets of benomyl and Rapamycin using next-generation sequencing of resistant mutants in S. cerevisiae
Effects of advanced age on whole-body protein synthesis and skeletal muscle mechanistic target of Rapamycin signaling in horses
Loss-of-function RNAi screens in breast cancer cells identify AURKB, PLK1, PIK3R1, MAPK12, PRKD2, and PTK6 as sensitizing targets of Rapamycin activity
Effect of inhibiting the signal of mammalian target of Rapamycin on memory T cells
Mammalian target of Rapamycin coordinates iron metabolism with iron-sulfur cluster assembly enzyme and tristetraprolin
Antiangiogenic therapy using sunitinib combined with Rapamycin retards tumor growth but promotes metastasis
Rapamycin inhibition of mTORC1 reverses lithium-induced proliferation of renal collecting duct cells
Rapamycin attenuates visible light-induced injury in retinal photoreceptor cells via inhibiting endoplasmic reticulum stress
Rapamycin-resistant poly (ADP-ribose) polymerase-1 overexpression is a potential therapeutic target in lymphangioleiomyomatosis
Mechanistic/mammalian target protein of Rapamycin signaling in hematopoietic stem cells and leukemia
Coupled cell morphology investigation and metabolomics analysis improves Rapamycin production in Streptomyces hygroscopicus
… nitric oxide synthase participates in pemphigus vulgaris acantholysis through upregulation of Rous sarcoma, mammalian target of Rapamycin and focal adhesion …
Diversified targets of FKBP25 and its complex with Rapamycin
Rapamycin increases pCREB, Bcl-2, and VEGF-A through ERK under normoxia
Topical application of Rapamycin ointment ameliorates Dermatophagoides farina body extract‐induced atopic dermatitis in NC/Nga mice
T cells and lung injury. Impact of Rapamycin
Autophagic inhibitor attenuates Rapamycin-induced inhibition of proliferation in cultured A549 lung cancer cells
inhibition of mammalian target of Rapamycin by Rapamycin increases the radiosensitivity of esophageal carcinoma Eca109 cells
Biodegradable Rapamycin-eluting nano-fiber membrane-covered metal stent placement to reduce fibroblast proliferation in experimental stricture in a canine model
Activation of mammalian target of Rapamycin mediates rat pain-related responses induced by BmK I, a sodium channel-specific modulator
Immune memory–boosting dose of Rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute …
Conversion from calcineurin inhibitor–based immunosuppression to mammalian target of Rapamycin inhibitors or belatacept in renal transplant recipients
Rapamycin resistant murine th9 cells have a stable in vivo phenotype and inhibit graft-versus-host reactivity
Rapamycin inhibits Toll-like receptor 4-induced pro-oncogenic function in head and neck squamous cell carcinoma
Novel targeting of Phoshatidylinositol-3 Kinase and Mammalian Target of Rapamycin (mTOR) in renal cell carcinoma
Draft genome sequence of Streptomyces Rapamycinicus strain NRRL 5491, the producer of the immunosuppressant Rapamycin
Should mammalian target of Rapamycin inhibitors be stopped in women with lymphangioleiomyomatosis awaiting lung transplantation?
ScFKBP12 bridges Rapamycin and AtTOR in Arabidopsis
… of microRNA-99a promotes cell invasion and down-regulates E-cadherin expression in pancreatic cancer cells by regulating mammalian target of Rapamycin
The effect of bortezomib and Rapamycin on telomerase activity in mantle cell lymphoma
Effects of Chronic Akt/mTOR inhibition by Rapamycin on Mechanical Overload–Induced Hypertrophy and Myosin Heavy Chain Transition in Masseter Muscle
New strategies to overcome resistance to mammalian target of Rapamycin inhibitors in breast cancer
MEDI-573, alone or in combination with mammalian target of Rapamycin inhibitors, targets the insulin-like growth factor pathway in sarcomas
Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system
Immunohistochemical analysis of the mechanistic target of Rapamycin and hypoxia signalling pathways in basal cell carcinoma and trichoepithelioma
Chronic mechanistic target of Rapamycin inhibition: preventing cancer to delay aging, or vice versa?
Tribbles homolog 3 attenuates mammalian target of Rapamycin complex-2 signaling and inflammation in the diabetic kidney
IL-12hi Rapamycin-Conditioned Dendritic Cells Mediate IFN-γ–Dependent Apoptosis of Alloreactive CD4+ T Cells In Vitro and Reduce Lethal Graft-Versus …
Phase 2 clinical trial of Rapamycin-resistant donor CD4+ Th2/Th1 (T-Rapa) cells after low-intensity allogeneic hematopoietic cell transplantation
… of cost-effectiveness of oral Rapamycin plus bare-metal stents versus first generation of drug-eluting stents (from the Randomized Oral Rapamycin in Argentina [ORAR …
Dysregulation of mammalian target of Rapamycin pathway in plasmacytoid variant of urothelial carcinoma of the urinary bladder
… protein 1 in radical nephrectomy specimens as a prognostic predictor in patients with metastatic renal cell carcinoma treated with mammalian target of Rapamycin …
Rapid regulation of nuclear proteins by Rapamycin‐induced translocation in fission yeast
Induction of cytokines and growth factors by Rapamycin in the microenvironment of brain metastases of lung cancer
Association of mammalian target of Rapamycin with aggressive type II endometrial carcinomas and poor outcome: a potential target treatment
Short-term Rapamycin treatment in mice has few effects on the transcriptome of white adipose tissue compared to dietary restriction
Mechanistic target of Rapamycin (mTOR) dependent regulation of thioredoxin interacting protein (TXNIP) transcription in hypoxia
The mammalian target of Rapamycin pathway in the basolateral amygdala is critical for nicotine-induced behavioural sensitization
Metastatic perivascular epithelioid cell tumor responding to mammalian target of Rapamycin inhibition
A new functional role for mechanistic/mammalian target of Rapamycin complex 1 (mTORC1) in the circadian regulation of L-type voltage-gated calcium …
Targeting gallbladder cancer: oncolytic virotherapy with myxoma virus is enhanced by Rapamycin in vitro and further improved by hyaluronan in vivo
The Akt-mTOR pathway in Down’s syndrome: the potential use of Rapamycin/rapalogs for treating cognitive deficits
Effects of level of nutrient intake and age on mammalian target of Rapamycin, insulin, and insulin-like growth factor-1 gene network expression in skeletal …
Mammalian target of Rapamycin complex I (mTORC1) activity in ras homologue enriched in brain (Rheb)-deficient mouse embryonic fibroblasts
Precursor engineering and cell physiological regulation for high level Rapamycin production by Streptomyces hygroscopicus
Rictor/mammalian target of Rapamycin 2 regulates the development of Notch1 induced murine T-cell acute lymphoblastic leukemia via forkhead box O3
Clinicopathologic significance and function of mammalian target of Rapamycin activation in esophageal squamous cell carcinoma
Rapamycin and mTOR inhibitors probably have therapeutic effects for post-operative cognitive dysfunction
The impact of everolimus versus other Rapamycin derivative-eluting stents on clinical outcomes in patients with coronary artery disease: A meta-analysis of 16 …
A domain in the transcription activator Gln3 specifically required for Rapamycin responsiveness
Combination of rituximab and mammalian target of Rapamycin inhibitor everolimus (RAD001) in diffuse large B-cell lymphoma
Dysregulation of the mammalian target of Rapamycin pathway in chromophobe renal cell carcinomas
Rapamycin ameliorates proteinuria and restores nephrin and podocin expression in experimental membranous nephropathy
… CYP2E1: miR-132/-212 targeting of CYP2E1 and role of phosphatidylinositol 3-kinase, Akt (protein kinase B), mammalian target of Rapamycin signaling in regulating …
The prolyl peptidases PRCP/PREP regulate IRS-1 stability critical for Rapamycin-induced feedback activation of PI3K and AKT
MicroRNA-21 is induced by Rapamycin in a model of tuberous sclerosis (TSC) and lymphangioleiomyomatosis (LAM)
Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of Rapamycin (mTOR)
Adenosine triphosphate promotes locomotor recovery after spinal cord injury by activating mammalian target of Rapamycin pathway in rats
Multi-scale optical imaging of the delayed type hypersensitivity reaction attenuated by Rapamycin
The combination of Rapamycin and MAPK inhibitors enhances the growth inhibitory effect on Nara-H cells
Rapamycin prevents N‐methyl‐D‐aspartate‐induced retinal damage through an ERK‐dependent mechanism in rats
Iron metabolism, hepcidin, and anemia in orthotopic heart transplantation recipients treated with mammalian target of Rapamycin
Adenosine Monophosphate–activated Protein Kinase/Mammalian Target of Rapamycin–dependent Autophagy Protects Human Dental Pulp Cells against Hypoxia
The novel phosphoinositide 3‐kinase–mammalian target of Rapamycin inhibitor, BEZ235, circumvents erlotinib resistance of epidermal growth factor receptor mutant …
Biological constraints limit the use of Rapamycin-inducible FKBP12-Inp54p for depleting PIP 2 in dorsal root ganglia neurons
Mammalian target of Rapamycin complex 1 (mTORC1) plays a role in Pasteurella multocida toxin (PMT)-induced protein synthesis and proliferation in Swiss …
Target of Rapamycin signaling regulates high mobility group protein association to chromatin, which functions to suppress necrotic cell death
Rapamycin-binding FKBP25 associates with diverse proteins that form large intracellular entities
Characterization of the immersion properties of the peripheral membrane anchor of the FATC domain of the kinase “target of Rapamycin” by NMR, oriented CD …
Stathmin Regulates Hypoxia-Inducible Factor-1 Expression through the Mammalian Target of Rapamycin Pathway in Ovarian Clear Cell Adenocarcinoma
Chemotherapy of skull base chordoma tailored on responsiveness of patient-derived tumor cells to Rapamycin
CD4+CD25−Nrp1+ T Cells Synergize with Rapamycin to Prevent Murine Cardiac Allorejection in Immunocompetent Recipients
Enteral delivery of proteins stimulates protein synthesis in human duodenal mucosa in the fed state through a mammalian target of Rapamycin–independent pathway
Tuberous sclerosis associated with polycystic kidney disease: effects of Rapamycin after renal transplantation
Rapamycin-enhanced mitomycin C-induced apoptotic death is mediated through the S6K1–Bad–Bak pathway in peritoneal carcinomatosis
Rapamycin combined with celecoxib enhanced antitumor effects of mono treatment on chronic myelogenous leukemia cells through downregulating mTOR pathway
Earle’s balanced salts solution and Rapamycin differentially regulate the Bacillus Calmette-Guerin-induced maturation of human dendritic cells
First-line Mammalian target of Rapamycin inhibition in metastatic renal cell carcinoma: an analysis of practice patterns from the International Metastatic Renal Cell …
Addition of Rapamycin to anti-CD3 antibody improves long-term glycaemia control in diabetic NOD mice
Limitations of IL-2 and Rapamycin in immunotherapy of type 1 diabetes
Deficiency of cardiac Acyl-CoA synthetase-1 induces diastolic dysfunction, but pathologic hypertrophy is reversed by Rapamycin
Pretreatment of Rapamycin before allogenic corneal transplant promotes graft survival through increasing CD4 (+) CD25 (+) Foxp3 (+) regulatory T cells
NVP-BEZ235, dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor, prominently enhances radiosensitivity of prostate cancer cell line PC-3
Rapamycin reduces Drosophila longevity under low nutrition
Insulin infusion stimulates whole-body protein synthesis and activates the upstream and downstream effectors of mechanistic target of Rapamycin signaling in the …
Bioprocess engineering aspects of Rapamycin (sirolimus) production: a review on past achievements and recent perspectives
Alterations of hypoxia-induced factor signaling pathway due to mammalian target of Rapamycin (mTOR) suppression in ovarian clear cell adenocarcinoma: in vivo and …
Rapamycin enhances TNF-α-induced secretion of IL-6 and IL-8 through suppressing PDCD4 degradation in orbital fibroblasts
Visible effects of Rapamycin (sirolimus) on human skin explants in vitro
Mammalian target of Rapamycin pathway activity in alveolar soft part sarcoma
Long-term effects of conversion from cyclosporine to Rapamycin on testicular function and morphology in a rat transplantation model
The enhancement of Rapamycin production using Streptomyces hygroscopicus through a simple pH-shifted control
Rrd1p, an RNA polymerase II-specific prolyl isomerase and activator of phosphoprotein phosphatase, promotes transcription independently of Rapamycin response
… significance and therapeutic potential of the activation of anaplastic lymphoma kinase/protein kinase B/mammalian target of Rapamycin signaling pathway in …
Activation of mammalian target of Rapamycin (mTOR) in triple negative feline mammary carcinomas
Placental, lipid, and glucidic effects of mammalian target of Rapamycin inhibitors: impact on fetal growth and metabolic disorders during pregnancy after solid organ …
The antiviral immune response in human conventional dendritic cells is controlled by the mammalian target of Rapamycin
inhibition of Rapamycin-induced Akt phosphorylation by cotylenin A correlates with their synergistic growth inhibition of cancer cells
Rapamycin enhances cetuximab cytotoxicity by inhibiting mTOR-mediated drug resistance in mesenchymal hepatoma cells
Mammalian target of Rapamycin (mTOR) inhibitors and combined chemotherapy in breast cancer: a meta-analysis of randomized controlled trials
Synthesis of Rapamycin glycoconjugates via a CuAAC-based approach
Galectin-9 in combination with Rapamycin induces cardiac allograft tolerance in mice
Rapamycin attenuates pulmonary allergic vasculitis in murine model by reducing TGF-β production in the lung
Rapamycin in fibrotic diseases: beneficial or detrimental agent?
Recovery from Rapamycin: drug-insensitive activity of yeast target of Rapamycin complex 1 (TORC1) supports residual proliferation that dilutes Rapamycin …
Rapamycin and PF4 induce apoptosis by upregulating Bax and down-regulating survivin in MNU-induced breast cancer
Synergistic anti-tumor effects of a novel phosphatidyl inositol-3 kinase/mammalian target of Rapamycin dual inhibitor BGT226 and gefitinib in non-small cell lung …
Down regulation of mammalian target of Rapamycin decreases HIF-1α and survivin expression in anoxic lung adenocarcinoma A549 cell to elemene and/or irradiation
Efficacy and safety of Rapamycin in treatment of children with epilepsy complicated with tuberous sclerosis
Oral erlotinib, but not Rapamycin, causes modest acceleration of bladder and hindlimb recovery from spinal cord injury in rats
p21WAF1/CIP1 expression is differentially regulated by metformin and Rapamycin
Alcohol consumption mitigates apoptosis and mammalian target of Rapamycin signaling in myocardium
Insights from yeast into whether the Rapamycin inhibition of heat shock transcription factor (Hsf1) can prevent the Hsf1 activation that results from treatment …
Immunotherapy with tolerogenic dendritic cells alone or in combination with Rapamycin does not reverse diabetes in NOD mice
Mammalian target of Rapamycin complex 2 signaling pathway regulates transient receptor potential cation channel 6 in podocytes
Successful mammalian target of Rapamycin inhibitor maintenance therapy following induction chemotherapy with gemcitabine and doxorubicin for metastatic …
Anti‐LFA‐1 or Rapamycin overcome costimulation blockade‐resistant rejection in sensitized bone marrow recipients
Interferon alpha and Rapamycin inhibit the growth of carcinoid and medullary thyroid cancer in vitro
In vitro and in vivo evaluation of Rapamycin-eluting nanofibers coated on cardia stents
Rapamycin does not inhibit human cytomegalovirus reactivation from dendritic cells in vitro
eIF4E-Overexpression imparts perillyl alcohol and Rapamycin-mediated regulation of telomerase reverse transcriptase
Clinical significance of aberrant mammalian target of Rapamycin expression in stage IIIB colon cancer
Multifaceted aging and Rapamycin
Effect of Rapamycin on spleen size in longstanding renal transplant recipients
Congenital segmental lymphedema in tuberous sclerosis complex with associated subependymal giant cell astrocytomas treated with mammalian target of Rapamycin …
Effect of Rapamycin-induced tumor vessel thrombosis combined with docetaxel in non-small-cell lung cancer
MicroRNA-100 promotes migration and invasion through mammalian target of Rapamycin in esophageal squamous cell carcinoma
Abstract C252: A phase 1, dose-escalation study of MLN0128, an investigational oral mammalian target of Rapamycin complex 1/2 (mTORC1/2) catalytic inhibitor, in …
Rapamycin-insensitive up-regulation of adipocyte phospholipase A2 in tuberous sclerosis and lymphangioleiomyomatosis
Mammalian target of Rapamycin complex 1 (mTORC1)-mediated phosphorylation stabilizes ISCU protein: implications for iron metabolism
Sequential use of mammalian target of Rapamycin inhibitors in patients with metastatic renal cell carcinoma following failure of tyrosine kinase inhibitors
The effects of viscosity and aeration rate on Rapamycin production in an airlift bioreactor by using Streptomyces hygroscopicus
Virtual screening and biochemical evaluation to identify new inhibitors of mammalian target of Rapamycin (mTOR)
Genetic Findings in Obsessive–Compulsive Disorder Connect to Brain‐Derived Neurotropic Factor and Mammalian Target of Rapamycin Pathways: Implications for …
Limited significance of activated Akt-mammalian target of Rapamycin signaling pathway in prostate cancer progression
Fusogenic pH sensitive liposomal formulation for Rapamycin: improvement of antiproliferative effect
The synergistic effect of Rapamycin combined with 5-fluorouracil in BALB/cByJNarl mice bearing CT-26 tumor cells
Transcriptome profiling of CTLs regulated by Rapamycin using RNA-Seq
Application of Response Surface Methodology To Formulation Optimization of Rapamycin Loaded Magnetic Fe3O4/Carboxymethylchitosan Nanoparticles
Dual inhibition of phosphatidylinositol 3′-kinase and mammalian target of Rapamycin using NVP-BEZ235 as a novel therapeutic approach for mucinous …
Rapamycin increases neuroblastoma xenograft and host stromal derived osteoprotegerin inhibiting osteolytic bone disease in a bone metastasis model
Signaling mechanisms that suppress the cytostatic actions of Rapamycin
Identification of the novel interacting partners of the mammalian target of Rapamycin complex 1 in human CCRF-CEM and HEK293 cells
… augment resistance exercise–induced increases in phosphatidylinositol 3 kinase/protein kinase B–mammalian target of Rapamycin pathway markers indicative of …
Rapamycin represses myotube hypertrophy and preserves viability of C2C12 cells during myogenesis in vitro
Dedifferentiated adenoid cystic carcinoma of the trachea: a case report with respect to the immunohistochemical analyses of mammalian target of Rapamycin pathway …
Distinct sensitivity of CD8+ CD4− and CD8+ CD4+ leukemic cell subpopulations to cyclophosphamide and Rapamycin in Notch1-induced T-ALL mouse model
Chronic intermittent hypoxia increases β cell mass and activates the mammalian target of Rapamycin/hypoxia inducible factor 1/vascular endothelial growth factor A …
… of thrones” in metastatic renal cell carcinoma: vascular endothelial growth factor-tyrosine kinase inhibitors and mammalian target of Rapamycin inhibitors battling for …
Dietary protein decreases exercise endurance through Rapamycin-sensitive suppression of muscle mitochondria
Characterization of residue-dependent differences in the peripheral membrane association of the FATC domain of the kinase ‘target of Rapamycin‘by NMR and …
hcrcn81 is upregulated by Rapamycin treatment in human colorectal adenocarcinoma cells
Role of Mammalian Target of Rapamycin (mTOR) in muscle growth
Contrasting effects of chronic, systemic treatment with mTOR inhibitors Rapamycin and metformin on adult neural progenitors in mice
Inhibitory effect and significance of Rapamycin on the mammalian target of Rapamycin signaling pathway in osteosarcoma stem cells and osteosarcoma cells
Crosstalk between Edc4 and mammalian target of Rapamycin complex 1 (mTORC1) signaling in mRNA decapping
Protein kinase C and P2Y12 take center stage in thrombin‐mediated activation of mammalian target of Rapamycin complex 1 in human platelets
Significance of mTOR (mammalian target of Rapamycin) activity in human lymphomas
Combination treatment with asiaticoside and Rapamycin: A new hope for in‑stent restenosis
EGF signalling and Rapamycin-mediated mTOR inhibition in glioblastoma multiforme evaluated by phospho-specific flow cytometry
MicroRNAs and the cellular response to Rapamycin: potential role in diagnosis and therapy
Expression of set is downregulated by Rapamycin in human colorectal cancer cells
Reactivation versus clearance of Mycobacterium tuberculosis using mammalian target of Rapamycin inhibitors in patients with cancer can be context dependent
Rapamycin inhibition of CFA-induced lymphangiogenesis in PLN is independent of mast cells
Short-course Rapamycin treatment preserves airway epithelium and protects against bronchiolitis obliterans
Telomerase expression abrogates Rapamycin-induced irreversible growth arrest of uterine fibroid smooth muscle cells
Rapamycin enhances adenovirus-mediated cancer imaging and therapy in pre-immunized murine hosts
Effects of Rapamycin on DC-SIGN expression and biological functions in DC
Differential gene expression profile of first-generation and second-generation Rapamycin-resistant allogeneic T cells
Expression of mammalian target of Rapamycin in atherosclerotic plaques is decreased under diabetic conditions: A mechanism for Rapamycin resistance
Mammalian target of Rapamycin complex 1 as an inducer of neurotrophic factors in dopaminergic neurons
… shows requirement of two processes: a destabilization of eIF4E: 4E-BP complex and a great stimulation of the 4E-BP-degradation mechanism, both Rapamycin …
A window into immunosuppressant immunoregulation: recipient conversion to Rapamycin increases potentially tolerogenic immune cells
A novel strategy inducing autophagic cell death in Burkitt’s lymphoma cells with anti-CD19-targeted liposomal Rapamycin
Differential role of Rapamycin and torin/KU63794 in inflammatory response of 264.7 RAW macrophages stimulated by CA-MRSA
Rapamycin decreases expression of thymidylate synthase and enhances the response to pemetrexed in preclinical studies and a Phase I/II clinical study of subjects …
Effects of Rapamycin on airway remodeling in asthmatic mice
Interleukin‐15 gene therapy and the mammalian target of Rapamycin inhibitor everolimus inhibit the growth of metastatic breast cancer
Effects of Rapamycin on biological characteristics of bone marrow mesenchymal stem cells from patients with aplastic anemia
Rapamycin promotes podocyte migration through the up-regulation of urokinase receptor
… of the face, similar to tuberous sclerosis complex-associated angiofibroma, shows activation of the mammalian target of Rapamycin pathway: evidence for a …
Kruppel-like factor 2 might mediate the Rapamycin-induced arterial thrombosis in vivo: implications for stent thrombosis in patients.
Molecular insights into the stabilization of protein–protein interactions with small molecule: The FKBP12–Rapamycin–FRB case study
Mammalian target of Rapamycin: a novel pathway in vascular calcification
Improvement of microbial strain and fermentation process of Rapamycin biosynthesis
Temporary placement of a paclitaxel or Rapamycin-eluting stent is effective to reduce stenting induced inflammatory reaction and scaring in benign cardia …
Combined antiangiogenic and mammalian target of Rapamycin inhibitor targeted therapy in metaplastic breast cancer harboring a PIK3CA mutation
Enhanced genetic modification of adult growth factor mobilized peripheral blood hematopoietic stem and progenitor cells with Rapamycin
inhibition of intimal hyperplasia by local perivascular application of Rapamycin and imatinib mesilate after carotid balloon injury
Mammalian target of Rapamycin inhibitor abrogates abnormal osteoclastogenesis in neurofibromatosis type 1
Rapamycin: Current and Future Uses
Attenuation of the activated mammalian target of Rapamycin pathway might be associated with renal function reserve by a low-protein diet in the rat remnant kidney …
Combination of Rapamycin and Imatinib in Treating Refractory Chronic Myeloid Leukemia Myeloid Blast Crisis: a Case Report025B3
A new Rapamycin-abluminally coated chitosan/heparin stent system accelerates early re-endothelialisation and improves anti-coagulant properties in porcine coronary …
Rapamycin helps to maintain colony forming efficiency in corneal epithelial cells
Influence of GABA on brain protein synthesis mediated by the mammalian target on the Rapamycin pathway
Establishment of an orthotopic mouse non-muscle invasive bladder cancer model expressing the mammalian target of Rapamycin signaling pathway
Loss of hydrophobic motif and activation loop phosphorylation is a consequence and not the mechanism of S6 kinase 1 inhibition by Rapamycin.
Activation of mammalian target of Rapamycin signaling pathway markers in minute adenocarcinoma of the prostate
Mammalian target of Rapamycin (mTOR) inhibition does not prevent lung adenocarcinoma‐induced malignant pleural effusion
Prophylaxis for Post-Traumatic Epilepsy: Can Your Kinase Do That? inhibition of Epileptogenesis with Rapamycin
Balloon coating with Rapamycin using an on-site coating device
Acute Rapamycin (RAP) exposure induce developmental, neurobehavioral and immunal toxicities in embryonic zebrafish
… determination of GDC-0980 (Apitolisib), a dual small-molecule inhibitor of class 1A phosphoinositide 3-kinase and mammalian target of Rapamycin, in human plasma
The yeast 14-3-3 proteins Bmh1 and Bmh2 differentially regulate Rapamycin-mediated transcription
Downregulation of RelA (p65) by Rapamycin inhibits murine adipocyte differentiation and reduces fat mass of C57BL/6J mice despite high fat diet
Dietary Rapamycin selectively improves arterial function in old mice
Designing and in-vitro characterization of micelle forming amphiphilic PEGylated Rapamycin nanocarriers for the treatment of gastric cancer.
A functional autophagy pathway is required for Rapamycin-induced degradation of the Sgs1 helicase in Saccharomyces cerevisiae
Selective Substitution of 31/42–OH in Rapamycin Guided by an in Situ IR Technique
Calcineurin inhibitor conversion to Rapamycin can improve graft function in living donor kidney transplantation with older donors
Preventing primate GvHD using a novel antagonistic anti-CD28 antibody plus Rapamycin: downregulation of CD8 activation and preservation of the naïve cell …
Designing and In-Vitro Characterization of Micelle Forming Amphiphilic PEGylated Rapamycin Nanocarriers for the Treatment of Gastric Cancer
Activation of mammalian target of Rapamycin (mTOR) in human restenosis
Centenarian lamins: Rapamycin targets in longevity
The immunosuppressant tributyltin oxide blocks the mTOR pathway, like Rapamycin, albeit by a different mechanism
Rapamycin down‐regulates REDD1 to blunt cell death: a potential way to maintain retinal ganglion cell function as in glaucoma
Mechanism for the synergistic effect of Rapamycin and resveratrol on hyperinsulinemia may involve the activation of protein kinase B
Enrichment of soymeal medium to increase the Rapamycin production by Streptomyces hygroscopicus
Predictive value of phosphorylated mammalian target of Rapamycin for disease‑free survival in breast cancer patients receiving neoadjuvant chemotherapy
Rapamycin for the treatment of refractory extensive chronic graft-versus-host disease
Effects of Rapamycin on expression of ten kinds autophagy-related miRNAs in RAW264. 7 macrophages
Rapamycin‐responsiveness and Gln3‐Tor1 interaction are associated with different target sites on the Gln3 protein (609.13)
Effect of intrathecal Rapamycin on diabetic neuropathic pain in rats
Incidence and risk of treatment-related mortality in patients with renal cell cancer (RCC) and non-RCC treated with mammalian target of Rapamycin (mTOR) inhibitors.
Expression and clinical significance of serine-threonine kinase/mammalian target of Rapamycin/p70 S6K signal pathway in oral squamous cell carcinoma.
Rapamycin to the rescue
Hyper-Activation of the Target of Rapamycin (Tor) Kinase 1 Decreases Intracellular Glutathione Content in Saccharomyces cerevisiae as Revealed by LC-MS/MS …
P7170, a novel inhibitor of phosphoinositide 3-kinase (PI3K)-mammalian target of Rapamycin (mTOR) and activin receptor-like kinase 1 (ALK1) shows anti-tumor …
Inhibitory effect of Rapamycin on the proliferation of Rhesus retinal vascular endothelial cells
Hanga Roa Hospital and Rapamycin
BG-12 (DIMETHYL fumarate) is neuroprotective in the murine cuprizone/Rapamycin model of demyelination and neurodegeneration (P05. 184)
Anticancer benefits of early versus late use of Rapamycin in a rat model of urothelial carcinoma
Rapamycin improves learning and memory ability in ICR mice with pilocarpine-induced temporal lobe epilepsy
Icotinib combined with Rapamycin in a renal transplant recipient with epidermal growth factor receptor‑mutated non‑small cell lung cancer: A case report
Hepatoprotective effect of Rapamycin in rats with obstructive jaundice
Effect of chemotherapy with cisplatin and Rapamycin on HeLa cells in vitro
Phosphatidylinositol-3 kinase-Akt-mammalian target of Rapamycin signaling pathway mediates contractility of human endometriotic stromal cells: A promising …
Antimycin induces apoptosis in Rapamycin resistant SW620 colorectal cancer cells
Novel stratification of the recurrence risk following surgical extirpation of clear cell renal cell carcinoma using tissue biomarkers in the mammalian target of Rapamycin …
The effects of mammalian target of Rapamycin inhibitors on serum uric acid levels in renal transplant patients
Chronic Rapamycin treatment decreases markers of autophagy and mitophagy in a sex‐specific manner (1094.8)
Risk evaluation and mitigation strategies: a focus on the mammalian target of Rapamycin inhibitors
Effects of Rapamycin on Dia2 in S. cerevisiae
Neointima reduction with IVUS and Rapamycin microbubbles: In Vivo swine model results
inhibition of mammalian target of Rapamycin induces renal mitochondrial uncoupling in rats
Mammalian target of Rapamycin regulates androgen receptor and Akt phosphorylation in prostate cancer 22RV1 cells
Targeting the mammalian target of Rapamycin pathway in osteosarcoma using combinative chemotherapy
Different Responses of Neointimal Cells to Imatinib Mesylate and Rapamycin Compared with Normal Vascular Smooth Muscle Cells
Interacting to control size: the roles of juvenile hormone, insulin/target of Rapamycin and ecydsone signaling in regulating body size in Drosophila.
Top-Accessed Article: Topical Rapamycin
Critical analysis of the potential for therapeutic targeting of mammalian target of Rapamycin (mTOR) in gastric cancer
Interferon‑α enhances the susceptibility of renal cell carcinoma to Rapamycin by suppressing mTOR activity
Influence of Rapamycin on Zea Mays Seedlings
Resistant mechanism about Rapamycin and solution
RhoA regulates the mechanistic target of Rapamycin complex 1 (mTORC1)
Effect of Rapamycin on pulmonary fibrosis in rats
Global Proteomics remodeling of cardiac aging and pressure-overload induced heart failure is attenuated by suppression RF target of Rapamycin
Acquired resistance to Rapamycin and mTOR kinase inhibitors is mediated by non-overlapping mutations in distinct sites in the mTOR protein
Effect of Rapamycin on the potential metastasis of squamous cell carcinoma in vitro
Effects of mammalian-target-of-Rapamycin pathway on lapatinib resistance in breast cancer MDA-MB-231 cells
A randomized phase II study (B2151005) of the intravenous phosphatidylinositol 3-kinase (PI3K)/mammalian target of Rapamycin (mTOR) inhibitor PF-05212384 plus …
B7-H1 Expression Is Critical to Cardiac Allograft Tolerance Induced By the Combination Therapy of Mesenchymal Stem Cells and Rapamycin.: Abstract# 2272
Use of mammalian target of Rapamycin inhibitor for treating pathologies including neurodegenerative diseases (Alzheimer’s disease), neuroinflammatory diseases and …
Involvement of Mammalian Target of Rapamycin Complexes in GM3 Mediated Melanoma Metastasis
Effects of Rapamycin on growth, apoptosis, and DDAH2 expression in liver cancer cells
Regulation of gene expression of mammalian target of Rapamycin
Effect of gluteus medius muscle sample collection depth on postprandial mammalian target of Rapamycin signaling in mature Thoroughbred mares
Abstract B18: Targeting Rapamycin-induced autophagy in cancer
… unprotected left main. Mid term results from a Prospective, Multicenter and Controlled Argentina Registry with a Cobalt-Chromium Rapamycin Eluting Stent, FIREBIRD …
Epithelial to mesenchymal transition and Rapamycin sensitivity in cancer cell lines.
Regulation of the Mechanistic Target of Rapamycin by Cellular Stress.
Chronic Rapamycin Treatment Confers Partially Reversible Diabetes Mellitus
Rapamycin promotes Glt1 expression and glutamate uptake inastrocyte
Modulation of endothelial cell-T cell interactions by Rapamycin
Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of Rapamycin (mTOR).
Periadventitial Application of Rapamycin-Loaded Nanoparticles Produces Sustained inhibition of
Mammalian Target of Rapamycin (mTOR)
Rapamycin As Treatment Of Lymphangioleiomyomatosis: Favorable Response In Different Clinical Manifestations
Regulation of the Target of Rapamycin Signaling Pathway in Saccharomyces cerevisiae
Effects of Rapamycin on atrial fibrosis in rats
Effects of Rapamycin on Monocytes from Pediatric Patients with Tuberous Sclerosis
Topical Rapamycin as a Treatment for Fibrofolliculomas in Birt-Hogg-Dubé
Effects of Rapamycin on proliferation of EC9706 cells transfected with p70S6K-siRNA
Research progress on feedback activation mechanism of mammalian target of Rapamycin in tumors
Mice Fed Rapamycin Have an Increase in Lifespan Associated with Major Changes in the
Perillyl alcohol and Rapamycin‐mediated inhibition of migration and invasion
Effect of Rapamycin in Proliferation and Apoptosis of Human Tongue Squamous Cell Carcinoma
Effects of Rapamycin combined with rosiglitazone on lung injury in septic rats
A novel way for neurodegenerative diseases within cell and animal model by autophagy induced with Rapamycin treatment
An aqueous clear Rapamycin topical drop for retinal delivery
P442 COMPARISON OF THE INHIBITORY EFFECTS OF Rapamycin ON THE DIFFERENT STAGES OF HEPATIC FIBROSIS
Determinants of sensitivity and resistance to Rapamycin-chemotherapy drug combinations in vivo. Cancer Res
The protective role of mammalian target of Rapamycin in the injury of podosytes induced by adriamycin
Rapamycin-resistant HIF-1α expression in hepatocellular carcinoma (HCC) cells and high sensitivity of endothelial cells within HCC tissues to Rapamycin.
Investigation into the effects and mechanisms of Rapamycin treatment in two mouse models of Complex I-deficient neurological pathology
TCT-837 Everolimus-eluting versus other Rapamycin derivatives-eluting stents in patients with coronary artery disease: a meta-analysis of 16 randomized trials
Rapamycin Augments Dendritic Cell Mediated Tumor Immunity
Novel Heregulin-Mediated Pathways To Mammalian Target Of Rapamycin Complex 1
B58 EXPERIMENTAL MODELS OF PULMONARY HYPERTENSION II: inhibition Of mTOR By Rapamycin Blocks Systemic Angiogenesis
P101 The effect of Rapamycin in cardiac mTORC2-deficient mice under pressure overload conditions.
A in vivo Study on the Neuroprotective Effects of Rapamycin Against Neurotoxic Aβ in Rats
… between the risk grade of gastrointestinal stromal tumor and expression of mammalian target of Rapamycin and phosphorylated mammalian target of Rapamycin
Addition of Rapamycin to Anti-CD3 Antibody Improves Long-Term Glycaemia Control in
The phosphatidyl-inositol 3-kinase/Akt/mammalian target of Rapamycin pathway as a therapeutic target in head and neck cancer
Mammalian Target of Rapamycin in Renal Cell Carcinoma
Dynamical models of the mammalian Target of Rapamycin network in ageing
Effects of Rapamycin administration on the diabetic rat placenta and embryo
Induction of central memory to BCG vaccine in mice through Rapamycin (P4300)
Differential Effects of Rapamycin Treatment on Cardiac Pathology in Lean and Obese Rats
The mechanistic target of Rapamycin pathway in sarcomas: from biology to therapy
Reperfusion Therapy With Rapamycin Protects Type 2 Diabetic Mouse Heart
Effect of Rapamycin Combined with Cisplatin on Apoptosis and Autophagy of Ovarian Cancer Cell Line SKOV3
mTOR Inhibitor MLN0128 has Antitumor Efficacy in Cell Lines With Intrinsic and Acquired Rapamycin-Resistance.
Rapamycin Effects on Antigen-Specific CD8 T cell Migration
Medium-and long-term efficacy and safety of domestic and imported Rapamycin-eluting stents
Rapamycin Induced Autophagy and Suppression in Human Leukemia Cells Proliferation
Role of mammalian target of Rapamycin in ischemia‐reperfusion induced kidney injury (692.11)
Cargo and Carrier Effects of Rapamycin-Loaded Perfluorocarbon Nanoparticles
Treating brain tumors with targeted-micelles containing Rapamycin
Mammalian target of Rapamycin inhibitors: the beginning of the end or the end of the beginning?
Effects of cyclosporine A and Rapamycin on the ability of dendritic cells to activate T cells
Experimental study on intraocular posterior capsule opacification in intraocular lens treated by Rapamycin
The Ure2 αCap Is Required for GATA Factor Responses to Rapamycin, But Not Nitrogen Limitation
Mammalian target of Rapamycin inhibitors for heart transplant patients
Rapamycin INHIBITS THORACIC AORTIC ANEURYSM FORMATION THROUGH SUPPRESSION OF PRO-INFLAMMATORY MEDIATORS
Outcome Of Rapamycin Therapy For Post Transplant-Lymphoproliferative Disorder After Kidney Transplantation: Case Series
The protective effects of Rapamycin on intestinal ischemia/reperfusion induced remote lung injury in mice
mTOR inhibitor MLN0128 Has antitumor efficacy in cell lines with intrinsic and acquired Rapamycin resistance in vitro and in vivo.
Long-term effectiveness and safety of Rapamycin-eluting stents in percutaneous coronary intervention of patients with coronary artery disease
Abstract A35: Identification of pro-survival Rapamycin-dependent microRNA (Rapa-miRs) in tuberous sclerosis complex
EFFECTS OF THE ANTI-AGING AGENT Rapamycin ON DISC MATRIX HOMEOSTASIS: GP75.
Mammalian target of Rapamycin inhibitors permit regulatory T cell reconstitution and inhibit experimental chronic graft-versus-host disease
The mammalian target of Rapamycin regulates lipid metabolism in osteoarthritic human articular cartilage
Abstract B035: Preneoplastic transformation of murine mammary stem cells by aging and inhibition by Rapamycin
Rapamycin prevents cadmium-induced neuronal cell death via suppressing MAPK and Akt/mTOR network
Prevention of murine sclerodermatous chronic graft-versus-host disease by Rapamycin
Topical Rapamycin for the treatment of facial angiofibromas with tuberous sclerosis complex
Correction: Mice Fed Rapamycin Have an Increase in Lifespan Associated with Major Changes in the Liver Transcriptome
B57 EXPERIMENTAL MODELS OF PULMONARY HYPERTENSION I: Effects Of Rapamycin On Pulmonary Vascular Remodeling Of Allergic Vasculitis In Murine …
Rapamycin reduces podocyte adhesion damage caused by sublytic C5b-9 via autophagy activation
Mammalian target of Rapamycin (mTOR): Structure, signaling pathways and biological effects
Porous Silicon Microparticle Formulation as an Intravitreal Delivery System for Rapamycin
Effect Of Long Term Rapamycin Treatment On mTOR Signalling Network In Colon And Liver Of C57bl/6 Mice
Synergistic Effects of Metformin in Combination with Rapamycin on Hepatocellular Carcinoma Cell Lines
Related research in mammalian target of Rapamycin signaling pathway and autophagy.
Rapamycin inhibits proliferation of human stomach cancer SGC-7901 cell line in vetro via downregulation of HIF-1α and VEGF
Perivascular Administration of Rapamycin Through Nanoparticles Prolongs inhibition of Arterial Restenosis
Abstract A163: A diverse array of mutations in mTOR are hyperactivating and correlate with Rapamycin sensitivity.
Developing a mouse model to study the metabolic role of the mammalian target of Rapamycin complex 1 in adipose tissue
Rapamycin increases radiosensitivity of cancer cells by induction of premature senescence.
Effect of LY294002 and Rapamycin on bim and bax in coxsackievirus B3 induced HeLa cells
Regulation of protein deposition by mammalian target of Rapamycin in piglets.
Rapamycin FOR THE TREATMENT OF AUTO-ANTIBODY INDUCED HAEMOLYSIS, IN A PATIENT WITH Β-THALASSEMIA MAJOR
Effect of NVP-BEZ235, dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor, on radiosensitivity of oral cancer cell line through G2/M phase …
The role of mammalian target of Rapamycin (mTOR) in macrophage polarization
Rapamycin‐Regulated Ubiquitin Specific Peptidases Expression in Cardiocytes
Different distribution and expression of mammalian target of Rapamycin complex in the kidney of diabetic nephropathy mice
… MECHANISMS OF RIGHT VENTRICULAR DYSFUNCTION: Worsening Right Ventricular Dysfunction By Fueling An Impaired Autophagic Flux With Rapamycin
Rapamycin is a chemopreventive and chemotherapeutic agent for ras-driven epidermal squamous cell carcinoma: evidence from mouse models.
mTOR inhibition by Rapamycin Alleviates Mitochondrial Disease in the Ndufs4-Mouse Model of Leigh Syndrome
Activation of mammalian target of Rapamycin contributes to rat nociceptive behaviors
Reperfusion Therapy With Rapamycin in Diabetic Heart: Essential Role of STAT3 Signaling
The role of mammalian target of Rapamycin (mTOR) in skin carcinogenesis
Activation of mammalian target of Rapamycin complex 1 (m TORC1) impairs urine concentration in mice
Distribution and significance of mammalian target of Rapamycin during differentiation of rat bone marrow mesenchymal stem cells into neurons
Correction: Beneficial Role of Rapamycin in Experimental Autoimmune Myositis
The effect of FK506 and Rapamycin on the expression of Foxp3+ Treg in liver cancer patients undergoing liver transplant and its clinical relevance
Effect study of Rapamycin on the expression of tumor helicase RECQ1 in glioma patients
Mammalian Target of Rapamycin (mTOR) Activity Dependent Phospho-Protein
Activation and its clinical significance of the mammalian target of Rapamycin pathway and its downstream proteins in gastric cancer
Activation and its clinical significance of the mammalian target of Rapamycin pathway and its downstream proteins in gastric cancer
Chronic Rapamycin Treatment Improves Cardiac Function by Attenuating Oxidative Stress and Altering Contractile Proteins in Type 2 Diabetic Mice
Retraction: Mammalian target of Rapamycin inhibitors for treatment in tuberous sclerosis
Rapamycin induces neuronal differentiation and decreases prion-like proteins in human glioblastoma cell cultures
SYSTEMIC Rapamycin TO PREVENT IN-STENT STENOSIS IN PERIPHERAL PULMONARY ARTERIAL DISEASE: EARLY CLINICAL EXPERIENCE
Build of lentiviral mediated RNA interference of mammalian target of Rapamycin
Effects of Rapamycin on the expression of HGF and TGF—β in chronic renal fibrosis of rats
A67 CLINICAL AND CELLULAR ASPECTS OF LYMPHANGIOLEIOMYOMATOSIS: Rapamycin As Treatment Of Lymphangioleiomyomatosis: Favorable Response In …
Tyrosine kinase inhibitors and mammalian target of Rapamycin inhibitors related to cardiac toxicity
Rapamycin Restores Cerebral Blood Flow and Blood Brain Barrier Integrity in APOE4 Carriers
Rapamycin Ameliorates Renal Ischemia/Reperfusion Injury via Remodeling Immune Microenvironment. SM J Urol. 2015; 1 (2): 1010
Iron Metabolism and Rapamycin (sirolimus)-Induced Microcytic Anemia in Renal Transplant Patients
The Role of the Mammalian Target of Rapamycin (mTOR) in Cytotoxic T Lymphocytes
Rapamycin Promotes Expansion of CD4+ CD25+ FOXP3+ Regulatory T Cells by Modulating Fatty Acid Metabolism?
Rapamycin modulates anti-and pro-thrombotic gene expressions via Kruppel-like factor 2: in vitro studies
Biology of Renal Cell Carcinoma (Vascular Endothelial Growth Factor, Mammalian Target of Rapamycin, Immune Aspects)
Subacute Treatment With Rapamycin Reverses Cardiac Aging by Proteome Remodeling and Improved Mitochondrial Energy Metabolism
Rapamycin Attenuates Cardiac Expression of Anti‐inflammatory AT2R and Anti‐Apoptotic MCL1
Regulation of the mammalian target of Rapamycin signaling by grape polyphenols in breast cancer (766.6)
Mammalian Target of Rapamycin Inhibitors Permit Regulatory T Cell Reconstitution
OP0285 Liver Mitochondria Dysfunction Precedes the Onset of SLE in Lupus-Prone Mice and is Ameliorated by Rapamycin and 3-Pehpc
Rapamycin Suppresses Astrocytic and Microglial Activation and Reduced Development of Neuropathic Pain after Spinal Cord Injury in Mice.
Npr2 regulates autophagy via Gtr1‐Gtr2‐dependent target of Rapamycin complex 1 signaling (539.11)
Rapamycin combined with atorvastatin attenuate oxidative stress injury in rat vascular smooth muscle cells.
Chronic Treatment With Novel Nanoformulated Micelles of Rapamycin, Rapatar, Protects Diabetic Heart Against Ischemia/reperfusion Injury
Targeting multiple components of the mammalian target of Rapamycin (mTOR) signaling: A novel combination therapy to improve pancreatic cancer treatment.
Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function
Rapamycin sensitizes cancer cells to growth inhibition by the PARP inhibitor olaparib
The Mammalian Target of Rapamycin Activation is Required for Monocyte Proinflammatory Response in Patients with Coronary Artery Disease
Expression and its clinical significance of mammalian target of Rapamycin and vascular endothelial growth factor in gastroenteropancreatic neuroendocrine neoplasm
Expression and its clinical significance of mammalian target of Rapamycin and vascular endothelial growth factor in gastroenteropancreatic neuroendocrine neoplasm
Rapamycin enhances the TNF-α-induced secretion of IL-6 and IL-8 by suppressing PDCD4 degradation in orbital fibroblasts
Rapamycin Promotes Expansion of CD4+ CD25+ FOXP3+ Regulatory T Cells By Modulating Fatty Acid Metabolism?: Abstract# D2799
Rapamycin Ameliorates Proteinuria and Restores Nephrin and Podocin Expression in Experimental Membranous Nephropathy
Elucidating The Regulatory Mechanisms Of The Mammalian Target Of Rapamycin Complex 1 (mTORc1) In Protein Homeostasis
Rapamycin promotes memory CD8 T cell development by regulating the Bim/Bcl-2 balance
Intra-articular administration of gelatin hydrogels incorporating Rapamycin-micelle reduces development of experimental osteoarthritis in a murine model
Research progress on the regulation of milk protein synthesis by essential amino acids through mammalian target of Rapamycin signaling pathway.
Hypoxia Regulation of Sensitivity to the Mechanistic Target of Rapamycin Kinase inhibition (mTORki) in Glioblastoma Multiforme
Rapamycin Expands and Confers Resistance to Apoptosis of Human Inducible Regulatory T Cells (TRI)
A Diverse Array of Cancer-Associated mTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity
A Diverse Array of Cancer-Associated mTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity
Rapamycin can overcome ABT-737 resistance in patient-derived SCLC xenograft models.
gln3 Mutations Dissociate Responses to Nitrogen Catabolite Repression and Rapamycin inhibition of TorC1
inhibition of the mammalian Target of Rapamycin (mTOR) does not alter nitric oxide or superoxide levels in human skin
Evidence that chronic inhibition of the mammalian Target of Rapamycin (mTOR) reduces skin blood flow in humans
Experimental study on the preventive effect of paclitaxel and Rapamycin composite drug-eluting stent on coronary restenosis in minipigs
Induction of Autophagy with Rapamycin overcomes Bcl‐2’s deleterious effects on stroke outcome
Donor Specific Transfusion Combined With Anti-CD134L and Rapamycin Inhibits Accelerated Rejection Mediated By Alloantigen-Primed Memory Cells in Mice …
Oral Rapamycin (eRapa) safely prevents carcinogen-induced dermal carcinogenesis through an interferon-γ-dependent mechanism (TUM7P. 931)
Rapamycin Can Reduce Apoptosis of CD4+ CD25+ Regulatory T Cells from Mouse Model of Severe Aplastic Anemia
Combination Of Regulatory T Cells and Rapamycin As Treatment For Experimental Chronic Graft-Versus-Host Disease
Rapamycin, an inhibitor of mTOR signaling pathway, reverses lithium‐induced cell proliferation in renal collecting ducts
The Mammalian Target of Rapamycin Complex 2 in Angiogenesis: An in vitro Analysis Using The Endothelial Tube Formation Assay
inhibition of mTOR With Rapamycin Reverses Cardiomyocyte-Specific Knockout of Pten-Induced Hypertrophic Cardiomyopathy
Efficient Induction and Expansion Of CD8+ CD28+ Foxp3+ Regulatory T Cells By TGF-beta1 and Rapamycin
Rapamycin-induced renal magnesium wasting associates with decreased TRPM6 expression and EGF stimulation
Rapamycin modulates the course of hepatitis B virus (HBV) infection in hydrodynamic injection mouse model: the role of Treg in HBV persistence
Effects of Rapamycin on granulation formation in response to centrally doubled coiled stents as a tracheal substitute
… I: Selective Tsc1 Deletion In Smooth Muscle Results In mTOR Signaling Activation And Development Of Pulmonary Hypertension That Can Be Reversed By Rapamycin
Investigation of a Putative Role for the Protein Kinase TOR (Target of Rapamycin) in microRNA-Mediated Gene Silencing in Drosophila Melanogaster
Effects of Rapamycin on transforming growth factor-β2-induced epithelial-myofibroblast transition of human lens epithelial cells
Impact of Rapamycin on phenotype and tolerogenic function of dendritic cells via intravital optical imaging
Correlation between release of Rapamycin from Porous Silicon (pSi) and the color shifting of pSi monitored by a digital camera: a prototype of non-invasive …
Polycystic Kidney Disease: Literature Review on the Mechanism of Mammalian Target of Rapamycin (mTOR) Inhibitors in the Reduction of Cyst Growth in Patients …
Neuroprotective Effect of Rapamycin (Autophagy Enhancer) in Transgenic SOD1-G93A Mice of Amyotrophic Lateral Sclerosis
Construction of a stable mouse fibroblast line targeting mammalian target of Rapamycin by lentivirus mediated short hairpin RNA
Abstract A168: Hepatitis B virus pre-S2 mutant stimulates aerobic glycolysis through mammalian target of Rapamycin signaling in tumorigenesis.
Activation of mammalian target of Rapamycin (mTOR) in triple negative feline mammary carcinomas
Molecular basis of the Rapamycin insensitivity of target of Rapamycin complex 2
Alternative Rapamycin treatment regimens mitigate the impact of Rapamycin on glucose homeostasis and the immune system
The mechanistic target of Rapamycin: the grand conducTOR of metabolism and aging
The enigma of Rapamycin dosage
inhibition of the mechanistic target of Rapamycin (mTOR)–Rapamycin and beyond
Transient Rapamycin treatment can increase lifespan and healthspan in middle-aged mice
Toward Rapamycin analog (rapalog)-based precision cancer therapy
Rapamycin‐mediated mTORC 2 inhibition is determined by the relative expression of FK 506‐binding proteins
Activation of mTOR (mechanistic target of Rapamycin) in rheumatic diseases
Rapamycin: an InhibiTOR of aging emerges from the soil of Easter Island
Health effects of long-term Rapamycin treatment: the impact on mouse health of enteric Rapamycin treatment from four months of age throughout life
How longevity research can lead to therapies for Alzheimer’s disease: The Rapamycin story
Rapamycin and rapalogs for tuberous sclerosis complex
Rapamycin in aging and disease: maximizing efficacy while minimizing side effects
Rapamycin blocks induction of the thermogenic program in white adipose tissue
New perspectives on mTOR inhibitors (Rapamycin, rapalogs and TORKinibs) in transplantation
Activation of the mechanistic target of Rapamycin in SLE: explosion of evidence in the last five years
About-face on the metabolic side effects of Rapamycin
Mammalian target of Rapamycin inhibition with Rapamycin mitigates radiation-induced pulmonary fibrosis in a murine model
Nanomicellar topical aqueous drop formulation of Rapamycin for back-of-the-eye delivery
Site-specific bioalkylation of Rapamycin by the RapM 16-O-methyltransferase
Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects
Rapamycin treatment benefits glucose metabolism in mouse models of type 2 diabetes
Synergistic antitumor activity of Rapamycin and EF24 via increasing ROS for the treatment of gastric cancer
Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts
Mechanistic target of Rapamycin (mTOR) in tuberous sclerosis complex-associated epilepsy
Dysregulation of mammalian target of Rapamycin signaling in mouse models of autism
Intermittent administration of Rapamycin extends the life span of female C57BL/6J mice
The opposing actions of target of Rapamycin and AMP-activated protein kinase in cell growth control
Mammalian target of Rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia
p53 and Rapamycin are additive
Rapamycin enhances survival in a Drosophila model of mitochondrial disease
Acute resistance exercise activates Rapamycin‐sensitive and‐insensitive mechanisms that control translational activity and capacity in skeletal muscle
Rapamycin-induced G1 cell cycle arrest employs both TGF-β and Rb pathways
Rapamycin increases neuronal survival, reduces inflammation and astrocyte proliferation after spinal cord injury
Rapamycin inhibits tumor growth of human osteosarcomas
Mammalian target of Rapamycin: its role in early neural development and in adult and aged brain function
Rapamycin preserves gut homeostasis during Drosophila aging
Mechanistically distinct cancer-associated mTOR activation clusters predict sensitivity to Rapamycin
Familial cortical dysplasia caused by mutation in the mammalian target of Rapamycin regulator NPRL3
The combination of Rapamycin and resveratrol blocks autophagy and induces apoptosis in breast cancer cells
Rapamycin Increases Mortality in db/db Mice, a Mouse Model of Type 2 Diabetes
Rapamycin protection of livers from ischemia and reperfusion injury is dependent on both autophagy induction and mammalian target of Rapamycin complex 2-Akt …
Stem cell guidance through the mechanistic target of Rapamycin
Target of Rapamycin complex 2 regulates actin polarization and endocytosis via multiple pathways
Efficacy and safety of mammalian target of Rapamycin inhibitors in vascular anomalies: a systematic review
Target of Rapamycin is a key player for auxin signaling transduction in Arabidopsis
Metformin and Rapamycin reduce pancreatic cancer growth in obese prediabetic mice by distinct microRNA-regulated mechanisms
Co-loaded paclitaxel/Rapamycin liposomes: development, characterization and in vitro and in vivo evaluation for breast cancer therapy
Pharmacological inhibition of ULK1 kinase blocks mammalian target of Rapamycin (mTOR)-dependent autophagy
Metformin potentiates Rapamycin and cisplatin in gastric cancer in mice
Testing efficacy of administration of the antiaging drug Rapamycin in a nonhuman primate, the common marmoset
Impact of Rapamycin on status epilepticus induced hippocampal pathology and weight gain
Light-cleavable Rapamycin dimer as an optical trigger for protein dimerization
Mutations in the mammalian target of Rapamycin pathway regulators NPRL2 and NPRL3 cause focal epilepsy
Target of Rapamycin (TOR) plays a critical role in triacylglycerol accumulation in microalgae
Rapamycin reduces severity of senile osteoporosis by activating osteocyte autophagy
Mammalian target of Rapamycin inhibitors and clinical outcomes in adult kidney transplant recipients
Co-delivery of Rapamycin-and piperine-loaded polymeric nanoparticles for breast cancer treatment
Rapamycin alleviates oxidative stress-induced damage in rat erythrocytes
3D molecular MR imaging of liver fibrosis and response to Rapamycin therapy in a bile duct ligation rat model
Rapamycin blocks the antidepressant effect of ketamine in task-dependent manner
Rapamycin attenuates acute lung injury induced by LPS through inhibition of Th17 cell proliferation in mice
Tomato FK506 binding protein 12KD (FKBP12) mediates the interaction between Rapamycin and target of Rapamycin (TOR)
Rapamycin does not prevent increases in myofibrillar or mitochondrial protein synthesis following endurance exercise
The 4E-BP–eIF4E axis promotes Rapamycin-sensitive growth and proliferation in lymphocytes
Recent advances in mammalian target of Rapamycin inhibitor use in heart and lung transplantation
Mitochondrial quality control via the PGC1α-TFEB signaling pathway is compromised by parkin Q311X mutation but independently restored by Rapamycin
… of resistance exercise training, matching deuterium oxide‐derived measures of muscle protein synthesis and mechanistic target of Rapamycin complex 1 signaling
Oral mucosal injury caused by mammalian target of Rapamycin inhibitors: emerging perspectives on pathobiology and impact on clinical practice
Subacute calorie restriction and Rapamycin discordantly alter mouse liver proteome homeostasis and reverse aging effects
Intermittent dosing of Rapamycin maintains antiepileptogenic effects in a mouse model of tuberous sclerosis complex
Integration of transcriptomics and metabolomics data specifies the metabolic response of Chlamydomonas to Rapamycin treatment
Rapamycin plays a neuroprotective effect after spinal cord injury via anti‐inflammatory effects
Sqstm1 knock-down causes a locomotor phenotype ameliorated by Rapamycin in a zebrafish model of ALS/FTLD
PAT4 levels control amino-acid sensitivity of Rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer
Classic K aposi’s sarcoma treated with topical Rapamycin
Optimization of a series of triazole containing mammalian target of Rapamycin (mTOR) kinase inhibitors and the discovery of CC-115
Effect of metformin, Rapamycin, and their combination on growth and progression of prostate tumors in HiMyc mice
Unraveling the role of the Target of Rapamycin signaling in sphingolipid metabolism
Blood–brain barrier leakage after status epilepticus in Rapamycin‐treated rats I: Magnetic resonance imaging
Inhibiting the Mammalian target of Rapamycin blocks the development of experimental cerebral malaria
Mitochondrial dysfunction in the liver and antiphospholipid antibody production precede disease onset and respond to Rapamycin in lupus‐prone mice
Rapamycin inhibition of eosinophil differentiation attenuates allergic airway inflammation in mice
Neuroprotective effect of Rapamycin on spinal cord injury via activation of the Wnt/β-catenin signaling pathway
Rapamycin reduced ischemic brain damage in diabetic animals is associated with suppressions of mTOR and ERK1/2 signaling
Local therapeutic efficacy with reduced systemic side effects by Rapamycin-loaded subcapsular microspheres
The neuroprotective effect of Rapamycin as a modulator of the mTOR-NF-κB axis during retinal inflammation
Cyclosporin a and Rapamycin relieve distinct lentiviral restriction blocks in hematopoietic stem and progenitor cells
Synergy between Rapamycin and FLT3 ligand enhances plasmacytoid dendritic cell–dependent induction of CD4+CD25+FoxP3+ Treg
inhibition of mammalian target of Rapamycin protects against reperfusion injury in diabetic heart through STAT3 signaling
TOR (target of Rapamycin) is a key regulator of triacylglycerol accumulation in microalgae
Effect of chronic administration of low dose Rapamycin on development and immunity in young rats
Effects of Rapamycin treatment on neurogenesis and synaptic reorganization in the dentate gyrus after controlled cortical impact injury in mice
Chronic mTOR inhibition in mice with Rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune‐deficient mice
… N-acetylcysteine-responsive accumulation of kynurenine in systemic lupus erythematosus: implications for activation of the mechanistic target of Rapamycin
Rapamycin and chloroquine: the in vitro and in vivo effects of autophagy-modifying drugs show promising results in valosin containing protein multisystem …
Targeted inhibition of rictor/mTORC2 in cancer treatment: a new era after Rapamycin
Immune-stimulatory effects of Rapamycin are mediated by stimulation of antitumor γδ T cells
Immunosuppression with mammalian target of Rapamycin inhibitor and incidence of post-transplant cancer in kidney transplant recipients
… model of neuronopathic Gaucher disease demonstrates lysosomal-autophagic defects and altered mTOR signalling and is functionally rescued by Rapamycin
Histone modifications change with age, dietary restriction and Rapamycin treatment in mouse brain
Rapamycin improves palmitate-induced ER stress/NF κ B pathways associated with stimulating autophagy in adipocytes
Rapamycin reveals an mTOR-independent repression of Kv1. 1 expression during epileptogenesis
Intravitreal injection of Rapamycin-loaded polymeric micelles for inhibition of ocular inflammation in rat model
Effects of Rapamycin pretreatment on blood-brain barrier disruption in cerebral ischemia-reperfusion
Rapamycin attenuates aldosterone-induced tubulointerstitial inflammation and fibrosis
The mammalian target of Rapamycin at the crossroad between cognitive aging and Alzheimer’s disease
Cystinosin is a component of the vacuolar H+-ATPase-ragulator-rag complex controlling mammalian target of Rapamycin complex 1 signaling
L-Tryptophan activates mammalian target of Rapamycin and enhances expression of tight junction proteins in intestinal porcine epithelial cells
Skin expression of mammalian target of Rapamycin and forkhead box transcription factor O1, and serum insulin‐like growth factor‐1 in patients with acne vulgaris and …
Rapamycin inhibits epithelial‐to‐mesenchymal transition of peritoneal mesothelium cells through regulation of Rho GTPases
Platelet-derived growth factor regulates vascular smooth muscle phenotype via mammalian target of Rapamycin complex 1
Phosphatidylinositol 3-kinase-AKT-mammalian target of Rapamycin (PI3K-Akt-mTOR) signaling pathway in non-small cell lung cancer
Rapamycin protects against gentamicin-induced acute kidney injury via autophagy in mini-pig models
Layer-by-layer-coated lyotropic liquid crystalline nanoparticles for active tumor targeting of Rapamycin
Mammalian target of Rapamycin controls glucose consumption and redox balance in human Sertoli cells
Yeast m6A Methylated mRNAs Are Enriched on Translating Ribosomes during Meiosis, and under Rapamycin Treatment
Repression of mammalian target of Rapamycin complex 1 inhibits intestinal regeneration in acute inflammatory bowel disease models
Epithelial to mesenchymal transition is associated with Rapamycin resistance
Anti-breast cancer potential of quercetin via the Akt/AMPK/mammalian target of Rapamycin (mTOR) signaling cascade
Metabolic consequences of long-term Rapamycin exposure on common marmoset monkeys (Callithrix jacchus)
Rapamycin loaded magnetic Fe3O4/carboxymethylchitosan nanoparticles as tumor-targeted drug delivery system: synthesis and in vitro characterization
Topical Rapamycin combined with pulsed dye laser in the treatment of capillary vascular malformations in Sturge-Weber syndrome: phase II, randomized, double-blind …
Downregulation of cancer stem cell properties via mTOR signaling pathway inhibition by Rapamycin in nasopharyngeal carcinoma
Effect of low-dose Rapamycin on senescence markers and physical functioning in older adults with coronary artery disease: results of a pilot study
In vitro and in vivo sustained zero-order delivery of Rapamycin (sirolimus) from a biodegradable intraocular device
Rapamycin ameliorates cadmium-induced activation of MAPK pathway and neuronal apoptosis by preventing mitochondrial ROS inactivation of PP2A
Rapamycin/DiR loaded lipid-polyaniline nanoparticles for dual-modal imaging guided enhanced photothermal and antiangiogenic combination therapy
Rapamycin protects against apoptotic neuronal death and improves neurologic function after traumatic brain injury in mice via modulation of the mTOR-p53-Bax axis
Imbalanced mechanistic target of Rapamycin C1 and C2 activity in the cerebellum of Angelman syndrome mice impairs motor function
Rapamycin improves motor function, reduces 4-hydroxynonenal adducted protein in brain, and attenuates synaptic injury in a mouse model of synucleinopathy
Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and …
The role of amino acid-induced mammalian target of Rapamycin complex 1 (mTORC1) signaling in insulin resistance
Olive oil‐derived oleocanthal as potent inhibitor of mammalian target of Rapamycin: biological evaluation and molecular modeling studies
Adaptations to chronic Rapamycin in mice
Optimal dietary alpha‐linolenic acid/linoleic acid ratio improved digestive and absorptive capacities and target of Rapamycin gene expression of juvenile grass carp (C …
The mammalian target of Rapamycin modulates the immunoproteasome system in the heart
Methylglyoxal activates the target of Rapamycin complex 2-protein kinase C signaling pathway in Saccharomyces cerevisiae
Inorganic polyphosphate elicits pro‐inflammatory responses through activation of the mammalian target of Rapamycin complexes 1 and 2 in vascular endothelial cells
inhibition of regulatory-associated protein of mechanistic target of Rapamycin prevents hyperoxia-induced lung injury by enhancing autophagy and reducing apoptosis …
Mammalian target of Rapamycin and tuberous sclerosis complex
Rapatar, a nanoformulation of Rapamycin, decreases chemically-induced benign prostate hyperplasia in rats
… reduces renal damage in ischemia/reperfusion injury: Unraveling antiapoptotic mechanisms and regulation of phosphorylated mammalian target of Rapamycin
Baicalein triggers autophagy and inhibits the protein kinase B/mammalian target of Rapamycin pathway in hepatocellular carcinoma HepG2 cells
Rapamycin-induced oligomer formation system of FRB–FKBP fusion proteins
Port wine stain treated with a combination of pulsed dye laser and topical Rapamycin ointment
SOX9-regulated cell plasticity in colorectal metastasis is attenuated by Rapamycin
Rapamycin-resistant mTOR activity is required for sensory axon regeneration induced by a conditioning lesion
Rapamycin reverses the senescent phenotype and improves immuno-regulation of mesenchymal stem cells from MRL/lpr mice and systemic lupus …
inhibition of mTOR pathway by Rapamycin reduces brain damage in rats subjected to transient forebrain ischemia
… of autophagic flux against xenoestrogen bisphenol-A-induced hippocampal neurodegeneration via AMP kinase (AMPK)/mammalian target of Rapamycin …
Surface engineering of porous silicon microparticles for intravitreal sustained delivery of Rapamycin
Differential effects of calcineurin and mammalian target of Rapamycin inhibitors on alloreactive Th1, Th17, and regulatory T cells
Rapidly progressive hypertrophic cardiomyopathy in an infant with Noonan syndrome with multiple lentigines: palliative treatment with a Rapamycin analog
Sustained delivery by a cyclodextrin material-based nanocarrier potentiates antiatherosclerotic activity of Rapamycin via selectively inhibiting mTORC1 in mice
Apoptotic effects of high-dose Rapamycin occur in S-phase of the cell cycle
Mechanistic target of Rapamycin complex 1 (mTORC1) and mTORC2 as key signaling intermediates in mesenchymal cell activation
Rapamycin-induced autophagy activity promotes bone fracture healing in rats
AKT inhibition overcomes Rapamycin resistance by enhancing the repressive function of PRAS40 on mTORC1/4E-BP1 axis
Rapamycin reduces motivated responding for cocaine and alters GluA1 expression in the ventral but not dorsal striatum
Complications of mammalian target of Rapamycin inhibitor anticancer treatment among patients with tuberous sclerosis complex are common and occasionally life …
The effect of mammalian target of Rapamycin inhibition on T helper type 17 and regulatory T cell differentiation in vitro and in vivo in kidney transplant recipients
Leucine and mammalian target of Rapamycin–dependent activation of muscle protein synthesis in aging
inhibition of mammalian target of Rapamycin attenuates early brain injury through modulating microglial polarization after experimental subarachnoid hemorrhage in …
Blocking mammalian target of Rapamycin (mTOR) attenuates HIF-1α pathways engaged-vascular endothelial growth factor (VEGF) in diabetic retinopathy
Effects of Rapamycin on cell apoptosis in MCF-7 human breast cancer cells
Dual-modal imaging-guided theranostic nanocarriers based on indocyanine green and mTOR inhibitor Rapamycin
Rapamycin attenuates cardiac fibrosis in experimental uremic cardiomyopathy by reducing marinobufagenin levels and inhibiting downstream pro‐fibrotic signaling
Increased mammalian target of Rapamycin signaling contributes to the accumulation of protein oxidative damage in a mouse model of Down’s syndrome
Transforming growth factor-β is an upstream regulator of mammalian target of Rapamycin complex 2–dependent bladder cancer cell migration and invasion
TORC1 inhibition by Rapamycin Promotes Antioxidant Defences in a Drosophila Model of Friedreich’s Ataxia
Effects of Rapamycin against paraquat-induced pulmonary fibrosis in mice
The Rapamycin-sensitive complex of mammalian target of Rapamycin is essential to maintain male fertility
Best: a randomized phase ii study of vascular endothelial growth factor, RAF kinase, and mammalian target of Rapamycin combination targeted therapy with …
Drug-related pneumonitis during mammalian target of Rapamycin inhibitor therapy: radiographic pattern-based approach in Waldenström macroglobulinemia …
Drug-related pneumonitis during mammalian target of Rapamycin inhibitor therapy in patients with neuroendocrine tumors: a radiographic pattern-based …
… regulates the apoptosis of bone marrow‐derived mesenchymal stem cells under hypoxic condition via AMP‐activated protein kinase/mammalian target of Rapamycin …
Fishmeal replacement by mixed plant proteins and maggot meal on growth performance, target of Rapamycin signalling and metabolism in juvenile turbot (S …
Quercetin inhibits fibroblast activation and kidney fibrosis involving the suppression of mammalian target of Rapamycin and β-catenin signaling
Rapamycin loaded solid lipid nanoparticles as a new tool to deliver mTOR inhibitors: formulation and in vitro characterization
Signaling through the phosphatidylinositol 3-kinase (PI3K)/mammalian target of Rapamycin (mTOR) axis is responsible for aerobic glycolysis mediated by …
Mammalian target of Rapamycin mediates kidney injury molecule 1-dependent tubule injury in a surrogate model
A phase Ib study of BEZ235, a dual inhibitor of phosphatidylinositol 3-kinase (PI3K) and mammalian target of Rapamycin (mTOR), in patients with advanced …
Rapamycin and dietary restriction induce metabolically distinctive changes in mouse liver
Blood–brain barrier leakage after status epilepticus in Rapamycin‐treated rats II: Potential mechanisms
Topical use of mammalian target of Rapamycin (mTOR) inhibitors in tuberous sclerosis complex—a comprehensive review of the literature
REDV/Rapamycin-loaded polymer combinations as a coordinated strategy to enhance endothelial cells selectivity for a stent system
On the discovery of TOR as the target of Rapamycin
Hepatitis B virus pre-S2 mutant induces aerobic glycolysis through mammalian target of Rapamycin signal cascade
Phase II study of dual phosphoinositol‐3‐kinase (PI 3K) and mammalian target of Rapamycin (mTOR) inhibitor BEZ 235 in patients with locally advanced or metastatic …
Rapamycin inhibits prostate cancer cell growth through cyclin D1 and enhances the cytotoxic efficacy of cisplatin
mTORC1 inhibitor Rapamycin and ER stressor tunicamycin induce differential patterns of ER-mitochondria coupling
Effect of dietary glutamine on growth performance, non-specific immunity, expression of cytokine genes, phosphorylation of target of Rapamycin (TOR), and anti …
Rapamycin ester analog CCI-779/Temsirolimus alleviates tau pathology and improves motor deficit in mutant tau transgenic mice
Formulation development and toxicity assessment of triacetin mediated nanoemulsions as novel delivery systems for Rapamycin
Comparative metabolic profiling reveals the key role of amino acids metabolism in the Rapamycin overproduction by Streptomyces hygroscopicus
Rapamycin suppresses PTZ-induced seizures at different developmental stages of zebrafish
Glycine Regulates Protein Turnover by Activating Protein Kinase B/Mammalian Target of Rapamycin and by Inhibiting MuRF1 and Atrogin-1 Gene Expression in …
Rapamycin inhibition of mTOR reduces levels of the Na+/H+ exchanger 3 in intestines of mice and humans, leading to diarrhea
Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down’s syndrome
Discovery of mammalian target of Rapamycin (mTOR) kinase inhibitor CC-223
Conophylline protects cells in cellular models of neurodegenerative diseases by inducing mammalian target of Rapamycin (mTOR)-independent autophagy
Pharmaceutical inhibition of mTOR in the common marmoset: effect of Rapamycin on regulators of proteostasis in a non-human primate
Rapamycin suppresses tumor growth and alters the metabolic phenotype in T-cell lymphoma
The immunosuppressive drug–Rapamycin–electroanalytical sensing using boron-doped diamond electrode
A NIR fluorescent probe: imaging endogenous hydrogen peroxide during an autophagy process induced by Rapamycin
Rapamycin inhibits lipopolysaccharide-induced neuroinflammation in vitro and in vivo
Targeting the mammalian target of Rapamycin in lung cancer
Mammalian target of Rapamycin complex 2 regulates invariant NKT cell development and function independent of promyelocytic leukemia zinc-finger
Leucine does not affect mechanistic target of Rapamycin complex 1 assembly but is required for maximal ribosomal protein s6 kinase 1 activity in human skeletal …
Sex-specific Tradeoffs With Growth and Fitness Following Life-span Extension by Rapamycin in an Outcrossing Nematode, Caenorhabditis remanei
Rapamycin attenuates age-associated changes in tibialis anterior tendon viscoelastic properties
Effects of Rapamycin on cerebral oxygen supply and consumption during reperfusion after cerebral ischemia
Huaier aqueous extract sensitizes cells to Rapamycin and cisplatin through activating mTOR signaling
Rapamycin and CTLA4Ig synergize to induce stable mixed chimerism without the need for CD40 blockade
Target of Rapamycin activation predicts lifespan in fruit flies
Rapamycin prevents, but does not reverse, aberrant migration in Pten knockout neurons
Unleashing Rapamycin in fibrosis
Metformin attenuates graft-versus-host disease via restricting mammalian target of Rapamycin/signal transducer and activator of transcription 3 and promoting …
Mechanistic target of Rapamycin (mTOR) regulates trophoblast folate uptake by modulating the cell surface expression of FR-α and the RFC
Prevention of irradiation-induced salivary hypofunction by Rapamycin in swine parotid glands
Muscle wasting in fasting requires activation of NF-κB and inhibition of AKT/mechanistic target of Rapamycin (mTOR) by the protein acetylase, GCN5
Postdepletion lymphocyte reconstitution during belatacept and Rapamycin treatment in kidney transplant recipients
Prevention of carcinogen and inflammation-induced dermal cancer by oral Rapamycin includes reducing genetic damage
Placenta growth factor induces invasion and activates p70 during Rapamycin treatment in trophoblast cells
Effects of dietary leucine supplementation on the gene expression of mammalian target of Rapamycin signaling pathway and intestinal development of broilers
Rapamycin inhibits human laryngotracheal stenosis–derived fibroblast proliferation, metabolism, and function in vitro
Perspective: the potential role of essential amino acids and the mechanistic target of Rapamycin complex 1 (mTORC1) pathway in the pathogenesis of child stunting
Successful topical Rapamycin treatment for facial angiofibromata in two children
Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
Rapamycin enhances the anti-cancer effect of dasatinib by suppressing Src/PI3K/mTOR pathway in NSCLC cells
Soy-dairy protein blend or whey protein isolate ingestion induces similar postexercise muscle mechanistic target of Rapamycin complex 1 signaling and protein …
Rapamycin attenuates mouse liver ischemia and reperfusion injury by inhibiting endoplasmic reticulum stress
Up‐regulation of the mammalian target of Rapamycin complex 1 subunit raptor by aldosterone induces abnormal pulmonary artery smooth muscle cell survival patterns …
Synergistic antitumor activity of the combination of salubrinal and Rapamycin against human cholangiocarcinoma cells
Effect of mammalian target of Rapamycin inhibitors on cytomegalovirus infection in kidney transplant recipients receiving polyclonal antilymphocyte globulins: a …
Rapamycin impairs endothelial cell function in human internal thoracic arteries
Addition of Rapamycin and hydroxychloroquine to metronomic chemotherapy as a second line treatment results in high salvage rates for refractory metastatic …
Combinatorial antitumor effect of Rapamycin and β-elemene in follicular thyroid cancer cells
Mammalian target of Rapamycin: a target for (lung) diseases and aging
Proximity-directed labeling reveals a new Rapamycin-induced heterodimer of FKBP25 and FRB in live cells
Development of a model describing regulation of casein synthesis by the mammalian target of Rapamycin (mTOR) signaling pathway in response to insulin …
Rapamycin ameliorates IgA nephropathy via cell cycle-dependent mechanisms
… growth factor β1-induced apoptosis in podocytes via the extracellular signal-regulated kinase-mammalian target of Rapamycin complex 1-NADPH oxidase 4 …
Valacyclovir combined with artesunate or Rapamycin improves the outcome of herpes simplex virus encephalitis in mice compared to antiviral therapy alone
Differential phosphorylation of a regulatory subunit of protein kinase CK2 by target of Rapamycin complex 1 signaling and the Cdc-like kinase Kns1
Rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17/Treg cell balance
Rapamycin and its analogues (rapalogs) for Tuberous Sclerosis Complex-associated tumors: a systematic review on non-randomized studies using meta …
Phase I study of apitolisib (GDC-0980), dual phosphatidylinositol-3-kinase and mammalian target of Rapamycin kinase inhibitor, in patients with advanced solid tumors
Pirarubicin induces an autophagic cytoprotective response through suppression of the mammalian target of Rapamycin signaling pathway in human bladder cancer …
Optimization of adipose tissue-derived mesenchymal stem cells by Rapamycin in a murine model of acute graft-versus-host disease
Blocking mammalian target of Rapamycin alleviates bone cancer pain and morphine tolerance via µ‐opioid receptor
The effect of Rapamycin on biodiesel-producing protist Euglena gracilis
Roles of mechanistic target of Rapamycin and transforming growth factor-β signaling in the molting gland (Y-organ) of the blackback land crab, Gecarcinus lateralis
Traumatic brain injury stimulates neural stem cell proliferation via mammalian target of Rapamycin signaling pathway activation
Blocking mammalian target of Rapamycin (mTOR) improves neuropathic pain evoked by spinal cord injury
Caloric restriction promotes the reserve of follicle pool in adult female rats by inhibiting the activation of mammalian target of Rapamycin signaling
Rapamycin inhibits oxidized low density lipoprotein uptake in human umbilical vein endothelial cells via mTOR/NF-κB/LOX-1 pathway
The anti-diabetic drug metformin inhibits vascular endothelial growth factor expression via the mammalian target of Rapamycin complex 1/hypoxia-inducible factor-1α …
The transcription factor p8 regulates autophagy in response to palmitic acid stress via a mammalian target of Rapamycin (mTOR)-independent signaling …
Ubiquilin-mediated small molecule inhibition of mammalian target of Rapamycin complex 1 (mTORC1) signaling
Combination therapy using IL-2/IL-2 monoclonal antibody complexes, Rapamycin, and islet autoantigen peptides increases regulatory T cell frequency and protects …
Randomized open-label phase II trial of apitolisib (GDC-0980), a novel inhibitor of the PI3K/mammalian target of Rapamycin pathway, versus everolimus in …
Chronic Rapamycin treatment on the nutrient utilization and metabolism of juvenile turbot (Psetta maxima)
Expression of mammalian target of Rapamycin and downstream targets in normal and gestational diabetic human term placenta
Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival
Rapamycin protects from type-I peritoneal membrane failure inhibiting the angiogenesis, lymphangiogenesis, and Endo-MT
Regulation of the target of Rapamycin and other phosphatidylinositol 3-kinase-related kinases by membrane targeting
Combination of an anti-EGFRvIII antibody CH12 with Rapamycin synergistically inhibits the growth of EGFRvIII+ PTEN− glioblastoma in vivo
Mammalian target of Rapamycin inhibitors and life-threatening conditions in tuberous sclerosis complex
Characterization of negative regulatory genes for the biosynthesis of Rapamycin in Streptomyces Rapamycinicus and its application for improved production
The pivotal role of mammalian target of Rapamycin inhibition in the treatment of patients with neuroendocrine tumors
Rapamycin increases fetal hemoglobin and ameliorates the nociception phenotype in sickle cell mice
Mammalian target of Rapamycin (mTOR) complex 2 regulates filamin A‐dependent focal adhesion dynamics and cell migration
Brain-expressed X-linked 2 is pivotal for hyperactive mechanistic target of Rapamycin (mTOR)-mediated tumorigenesis
The effect of different dosing schedules of intravitreal sirolimus, a mammalian target of Rapamycin (mTOR) inhibitor, in the treatment of non-infectious uveitis …
Wogonin increases β-amyloid clearance and inhibits tau phosphorylation via inhibition of mammalian target of Rapamycin: potential drug to treat Alzheimer’s disease
Rapamycin increases length and mechanosensory function of primary cilia in renal epithelial and vascular endothelial cells
Analysis of proteins that rapidly change upon mechanistic/mammalian target of Rapamycin complex 1 (mTORC1) repression identifies Parkinson protein 7 …
Characterization of the Nocardiopsin Biosynthetic Gene Cluster Reveals Similarities to and Differences from the Rapamycin and FK‐506 Pathways
Rapamycin, a specific inhibitor of the target of Rapamycin complex 1, disrupts intestinal barrier integrity in broiler chicks
The mechanism of Rapamycin in the intervention of paraquat-induced acute lung injury in rats
Rapamycin ameliorates experimental autoimmune uveoretinitis by inhibiting Th1/Th2/Th17 cells and upregulating CD4+ CD25+ Foxp3 regulatory T cells
Rapamycin influences the efficiency of in vitro fertilization and development in the mouse: a role for autophagic activation
Profiling of the fetal and adult rat liver transcriptome and translatome reveals discordant regulation by the mechanistic target of Rapamycin (mTOR)
Mechanistic target of Rapamycin complex 1/S6 kinase 1 signals influence T cell activation independently of ribosomal protein S6 phosphorylation
Pharmacodynamic monitoring of mammalian target of Rapamycin inhibition by phosphoflow cytometric determination of p70S6 kinase activity
Hyperglycemia and phosphatidylinositol 3-kinase/protein kinase B/mammalian target of Rapamycin (PI3K/AKT/mTOR) inhibitors in phase I trials: incidence …
Rapamycin reverses paraquat-induced acute lung injury in a rat model through inhibition of NFκB activation
Primary intestinal lymphangiectasia treated with Rapamycin in a child with tuberous sclerosis complex (TSC)
Interferon γ (IFNγ) signaling via mechanistic target of Rapamycin complex 2 (mTORC2) and regulatory effects in the generation of type II interferon biological …
Mammalian target of Rapamycin signaling pathway changes with intestinal epithelial cells renewal along crypt-villus axis
Efficacy of Rapamycin as inducer of Hb F in primary erythroid cultures from sickle cell disease and β-thalassemia patients
A central role for the mammalian target of Rapamycin in LPS-induced anorexia in mice
Intrathecal Rapamycin attenuates morphine-induced analgesic tolerance and hyperalgesia in rats with neuropathic pain
Phosphorylation of ribosomal protein S6 mediates mammalian target of Rapamycin complex 1–induced parathyroid cell proliferation in secondary hyperparathyroidism
Rapamycin increases CCN2 expression of lung fibroblasts via phosphoinositide 3-kinase
Amino acid sensing and activation of mechanistic target of Rapamycin complex 1: implications for skeletal muscle
Rapamycin‐induced autophagy sensitizes A549 cells to radiation associated with DNA damage repair inhibition
Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of Rapamycin complex 1 in mice
Rapamycin protects cardiomyocytes against anoxia/reoxygenation injury by inducing autophagy through the PI3k/Akt pathway
Paradoxical effect of Rapamycin on inflammatory stress-induced insulin resistance in vitro and in vivo
Effect of Rapamycin on endometriosis in mice
Mammalian target of Rapamycin (mTOR) tagging promotes dendritic branch variability through the capture of Ca2+/calmodulin-dependent protein kinase II α …
Combined treatment of Nimotuzumab and Rapamycin is effective against temozolomide-resistant human gliomas regardless of the EGFR mutation status
Effects of combining Rapamycin and resveratrol on apoptosis and growth of TSC2-deficient xenograft tumors
Particulate matter 2.5 induces autophagy via inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin kinase signaling pathway in …
Th1, Th2 and Th17 cytokine profile in patients with multiple sclerosis following treatment with Rapamycin
Mechanistic target of Rapamycin (mTOR) inhibition synergizes with reduced internal ribosome entry site (IRES)-mediated translation of cyclin D1 and c-MYC …
A phase I–II study on the combination of Rapamycin and short course radiotherapy in rectal cancer
Mechanical stretch activates mammalian target of Rapamycin and AMP-activated protein kinase pathways in skeletal muscle cells
Safety considerations of mammalian target of Rapamycin inhibitors in tuberous sclerosis complex and renal transplantation
Self-assembled micelles of amphiphilic PEGylated Rapamycin for loading paclitaxel and resisting multidrug resistant cancer cells
Defining the domain arrangement of the mammalian target of Rapamycin complex component Rictor protein
Target of Rapamycin signaling mediates vacuolar fission caused by endoplasmic reticulum stress in Saccharomyces cerevisiae
Ciliary transport regulates PDGF-AA/αα signaling via elevated mammalian target of Rapamycin signaling and diminished PP2A activity
Anorexic response to Rapamycin does not appear to involve a central mechanism
Rapamycin versus intermittent feeding: dissociable effects on physiological and behavioral outcomes when initiated early and late in life
Conversion from calcineurin to mammalian target of Rapamycin inhibitors in liver transplantation: a meta-analysis of randomized controlled trials
Rapamycin-Mediated mTOR inhibition Reverses Drug Resistance to Adriamycin in Colon Cancer Cells.
Rapamycin-loaded solid lipid nanoparticles: Morphology and impact of the drug loading on the phase transition between lipid polymorphs
5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR) enhances the efficacy of Rapamycin in human cancer cells
Cardiac energy dependence on glucose increases metabolites related to glutathione and activates metabolic genes controlled by mechanistic target of Rapamycin
Rapamycin protects neurons from brain contusion‑induced inflammatory reaction via modulation of microglial activation
Rapamycin inhibited the function of lung CSCs via SOX2
iPSC-MSCs combined with low-dose Rapamycin induced islet allograft tolerance through suppressing Th1 and enhancing regulatory T-cell differentiation
Dual PI3K/mTOR inhibitor, XL765 (SAR245409), shows superior effects to sole PI3K [XL147 (SAR245408)] or mTOR [Rapamycin] inhibition in prostate cancer cell …
Encapsulation and controlled release of Rapamycin from polycaprolactone nanoparticles prepared by membrane micromixing combined with antisolvent precipitation
Active mechanistic target of Rapamycin plays an ancillary rather than essential role in zebrafish CNS axon regeneration
First-line and sequential use of pazopanib followed by mammalian target of Rapamycin inhibitor therapy among patients with advanced renal cell carcinoma in a US …
Mammalian target of Rapamycin inhibitor RAD001 sensitizes endometrial cancer cells to paclitaxel-induced apoptosis via the induction of autophagy
Mechanistic target of Rapamycin complex 1 is an essential mediator of metabolic and mitogenic effects of fibroblast growth factor 19 in hepatoma cells
Rapamycin/GABA combination treatment ameliorates diabetes in NOD mice
Isoflurane promotes non-small cell lung cancer malignancy by activating the Akt-mammalian target of Rapamycin (mTOR) signaling pathway
Synergistic effect of JQ 1 and Rapamycin for treatment of human osteosarcoma
Local application of Rapamycin reduces epidural fibrosis after laminectomy via inhibiting fibroblast proliferation and prompting apoptosis
SR4 uncouples mitochondrial oxidative phosphorylation, modulates AMP-dependent kinase (AMPK)-mammalian target of Rapamycin (mTOR) signaling, and …
Rapamycin, a mTOR inhibitor, induced growth inhibition in retinoblastoma Y79 cell via down-regulation of Bmi-1
Four-week Rapamycin treatment improves muscular dystrophy in a fukutin-deficient mouse model of dystroglycanopathy
Rapamycin normalizes serum leptin by alleviating obesity and reducing leptin synthesis in aged rats
L-arginine upregulates the gene expression of target of Rapamycin signaling pathway and stimulates protein synthesis in chicken intestinal epithelial cells
Blockade of excitatory synaptogenesis with proximal dendrites of dentate granule cells following Rapamycin treatment in a mouse model of temporal lobe epilepsy
Rapamycin treatment during in vitro maturation of oocytes improves embryonic development after parthenogenesis and somatic cell nuclear transfer in pigs
Dual phosphoinositide 3-kinase/mammalian target of Rapamycin inhibitor is an effective radiosensitizer for colorectal cancer
Intrathecal administration of Rapamycin inhibits the phosphorylation of DRG Nav1. 8 and attenuates STZ-induced painful diabetic neuropathy in rats
Chemical genomics approach to identify genes associated with sensitivity to Rapamycin in the fission yeast Schizosaccharomyces pombe
Yes‐associated protein 1 and transcriptional coactivator with PDZ‐binding motif activate the mammalian target of Rapamycin complex 1 pathway by regulating amino …
Validation of mammalian target of Rapamycin biomarker panel in patients with clear cell renal cell carcinoma
The rodent malaria liver stage survives in the Rapamycin-induced autophagosome of infected Hepa1–6 cells
inhibition of MDM2 Re-sensitizes Rapamycin resistant renal cancer cells via the activation of p53
Expression of zTOR-associated microRNAs in zebrafish embryo treated with Rapamycin
Glucocorticoids inhibited hypothalamic target of Rapamycin in high fat diet-fed chicks
Diosmetin inhibits cell proliferation and induces apoptosis by regulating autophagy via the mammalian target of Rapamycin pathway in hepatocellular …
Outcome of Rapamycin therapy for post-transplant-lymphoproliferative disorder after kidney transplantation: case series
Therapeutic targeting of the IL-6 trans-signaling/mechanistic target of Rapamycin complex 1 axis in pulmonary emphysema
Rapamycin prevents bronchiolitis obliterans through increasing infiltration of regulatory B cells in a murine tracheal transplantation model
… of K562 cells treated with mithramycin is associated with inhibition of raptor gene transcription and mammalian target of Rapamycin complex 1 (mTORC1) …
Suppression of the proliferation of hypoxia‐Induced retinal pigment epithelial cell by Rapamycin through the/mTOR/HIF‐1α/VEGF/signaling
Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor NVP-BEZ235 against osteosarcoma
Preparation and preclinical evaluation of inhalable particles containing Rapamycin and anti-tuberculosis agents for induction of autophagy
Lipin-1 regulates cancer cell phenotype and is a potential target to potentiate Rapamycin treatment
Efficacy and safety of a mammalian target of Rapamycin inhibitor in pediatric patients with tuberous sclerosis complex: A systematic review and meta-analysis
Mammalian target of Rapamycin overexpression antagonizes chronic hypoxia-triggered pulmonary arterial hypertension via the autophagic pathway
Mammalian target of Rapamycin complex 2 (mTORC2) regulates LPS‐induced expression of IL‐12 and IL‐23 in human dendritic cells
Comparative analysis of Rapamycin biosynthesis clusters between Actinoplanes sp. N902-109 and Streptomyces hygroscopicus ATCC29253
… acid broadly suppresses cancer metabolism and synergistically induces strong anticancer activity in combination with etoposide, Rapamycin and UCN-01
inhibition of Akt enhances the chemopreventive effects of topical Rapamycin in mouse skin
Comparative analysis of protocols to induce human CD4+ Foxp3+ regulatory T cells by combinations of IL-2, TGF-beta, retinoic acid, Rapamycin and butyrate
Role of the mammalian target of Rapamycin pathway and Rapamycin in lentiviral vector gene transduction of hematopoietic stem cells
Dysregulation of anergy‐related factors involved in regulatory T cells defects in Systemic Lupus Erythematosus patients: Rapamycin and Vitamin D efficacy in …
Profibrotic up‐regulation of glucose transporter 1 by TGF‐β involves activation of MEK and mammalian target of Rapamycin complex 2 pathways
Screening of mammalian target of Rapamycin inhibitors in natural product extracts by capillary electrophoresis in combination with high performance liquid …
Mammalian target of Rapamycin complex (mTOR) pathway modulates blood-testis barrier (BTB) function through F-actin organization and gap junction
Rapamycin inhibits BAFF-stimulated cell proliferation and survival by suppressing mTOR-mediated PP2A-Erk1/2 signaling pathway in normal and neoplastic B …
Rapamycin, an mTOR inhibitor, induced apoptosis via independent mitochondrial and death receptor pathway in retinoblastoma Y79 cell
Peroxisome proliferator‑activated receptor‑γ agonist inhibits the mammalian target of Rapamycin signaling pathway and has a protective effect in a rat model of …
Rapamycin interferes with postdepletion regulatory T cell homeostasis and enhances DSA formation corrected by CTLA4‐Ig
Rapamycin regulates the proliferation of Huh7, a hepatocellular carcinoma cell line, by up-regulating p53 expression
… activating polypeptide II contributes to the inhibition of malignant biological behaviors by the combination of EMAP II with Rapamycin in human glioblastoma
Nephrin contributes to insulin secretion and affects mammalian target of Rapamycin signaling independently of insulin receptor
Rapamycin reduces fibroblast proliferation without causing quiescence and induces STAT5A/B-mediated cytokine production
Renal tumours in a Tsc2+/− mouse model do not show feedback inhibition of Akt and are effectively prevented by Rapamycin
17ss-Estradiol regulates mTORC2 sensitivity to Rapamycin in adaptive cardiac remodeling
Rapamycin and fructose-1, 6-bisphosphate reduce the HEPG2 cell proliferation via increase of free radicals and apoptosis
The mechanistic target of Rapamycin (mTOR) pathway and S6 Kinase mediate diazoxide preconditioning in primary rat cortical neurons
Different in vitro proliferation and cytokine‐production inhibition of memory T‐cell subsets after calcineurin and mammalian target of Rapamycin inhibitors treatment
Functional proteomics identifies acinus L as a direct insulin-and amino acid-dependent mammalian target of Rapamycin complex 1 (mTORC1) substrate
Phosphorylated mammalian target of Rapamycin p-mTOR is a favorable prognostic factor than mTOR in gastric cancer
Formaldehyde exposure inhibits the expression of mammalian target of Rapamycin in rat testis
Rapamycin attenuates splenomegaly in both intrahepatic and prehepatic portal hypertensive rats by blocking mTOR signaling pathway
Transforming somatic mutations of mammalian target of Rapamycin kinase in human cancer
Significance of mammalian target of Rapamycin in patients with locally advanced stage IV head and neck squamous cell carcinoma receiving induction chemotherapy …
NFκB up-regulation of glucose transporter 3 is essential for hyperactive mammalian target of Rapamycin-induced aerobic glycolysis and tumor growth
Local in vitro delivery of Rapamycin from electrospun PEO/PDLLA nanofibers for glioblastoma treatment
Target of Rapamycin Complex 2 regulates cell growth via Myc in Drosophila
Expression and clinical significance of mammalian target of Rapamycin/P70 ribosomal protein S6 kinase signaling pathway in human colorectal carcinoma …
Rapamycin prevents cadmium-induced neuronal cell death via targeting both mTORC1 and mTORC2 pathways
Differential effects of Rapamycin treatment on tonic and phasic GABAergic inhibition in dentate granule cells after focal brain injury in mice
The effect of Rapamycin on oxidative stress in MCF-7 and MDA MB-231 human breast cancer cell lines
Rapamycin inhibits Erk1/2-mediated neuronal apoptosis caused by cadmium
Discovery of leucyladenylate sulfamates as novel leucyl-tRNA synthetase (LRS)-targeted mammalian target of Rapamycin complex 1 (mTORC1) inhibitors
… and anti-apoptotic effects of memantine in a SH-SY5Y cell model of Alzheimer’s disease via mammalian target of Rapamycin-dependent and-independent …
Targeting Rapamycin to podocytes using a vascular cell adhesion molecule-1 (VCAM-1)-harnessed SAINT-based lipid carrier system
Rapamycin promotes the autophagic degradation of oxidized low-density lipoprotein in human umbilical vein endothelial cells
Effects of topically applied Rapamycin and mycophenolic acid on TNCB-induced atopic dermatitis-like skin lesions in NC/Nga mice
Rapamycin ameliorates brain metabolites alterations after transient focal ischemia in rats
Rapamycin promotes mouse 4T1 tumor metastasis that can be reversed by a dendritic cell-based vaccine
Angiographic and volumetric effects of mammalian target of Rapamycin inhibitors on angiomyolipomas in tuberous sclerosis
Effects of metformin and a mammalian target of Rapamycin (mTOR) ATP-competitive inhibitor on targeted metabolomics in pancreatic cancer cell line
Rapamycin safeguards lymphocytes from DNA damage accumulation in vivo
The mechanism of synergistic effects of arsenic trioxide and Rapamycin in acute myeloid leukemia cell lines lacking typical t (15; 17) translocation
Anti-tumor effect of the mammalian target of Rapamycin inhibitor everolimus in oral squamous cell carcinoma
Functionally conserved effects of Rapamycin exposure on zebrafish
Neuroendocrine tumors resistant to mammalian target of Rapamycin inhibitors: A difficult conversion from biology to the clinic
Fucoidan inhibits the migration and proliferation of HT-29 human colon cancer cells via the phosphoinositide-3 kinase/Akt/mechanistic target of Rapamycin …
Preventive effects of Rapamycin on inflammation and capillary degeneration in a rat model of NMDA-induced retinal injury
Profiling the role of mammalian target of Rapamycin in the vascular smooth muscle metabolome in pulmonary arterial hypertension
Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes
Relationship between mammalian target of Rapamycin and autophagy in lipopolysaccharide-induced lung injury
CX-5461 induces autophagy and inhibits tumor growth via mammalian target of Rapamycin-related signaling pathways in osteosarcoma
Rapamycin protects dopaminergic neurons against rotenone-induced cell death in primary mesencephalic cell culture
Downregulation of p70S6K enhances cell sensitivity to Rapamycin in esophageal squamous cell carcinoma
… and pharmacodynamics of SAR245409 (voxtalisib, XL765), an orally administered phosphoinositide 3-kinase/mammalian target of Rapamycin inhibitor: a phase 1 …
Combined image guided monitoring the pharmacokinetics of Rapamycin loaded human serum albumin nanoparticles with a split luciferase reporter
Celecoxib sensitizes gastric cancer to Rapamycin via inhibition of the Cbl-b-regulated PI3K/Akt pathway
Effects of Rapamycin on reduction of peridural fibrosis: an experimental study
Long-term alcohol-induced activation of mammalian target of Rapamycin is a key risk factor of epilepsy
Time-dependent effects of Rapamycin on consolidation of predator stress-induced hyperarousal
Plum polyphenols inhibit colorectal aberrant crypt foci formation in rats: potential role of the miR-143/protein kinase B/mammalian target of Rapamycin axis
Tuberous Sclerosis Complex 1–Mechanistic Target of Rapamycin Complex 1 Signaling Determines Brown-to-White Adipocyte Phenotypic Switch
Rapamycin and WYE-354 suppress human gallbladder cancer xenografts in mice
… inhibition enhances colorectal cancer apoptosis induced by dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor NVP-BEZ235
Stents coated with mammalian target of Rapamycin inhibitors (mTOR) appear to be the best choice in patients with antiphospholipid syndrome and myocardial …
Susceptibility of PTEN-positive metastatic tumors to small interfering RNA targeting the mammalian target of Rapamycin
Microsphere-based Rapamycin delivery, systemic versus local administration in a rat model of renal ischemia/reperfusion injury
… sorting complex required for transport pathway mediates chemokine receptor CXCR4-promoted lysosomal degradation of the mammalian target of Rapamycin …
A comprehensive proteomic and phosphoproteomic analysis of yeast deletion mutants of 14‐3‐3 orthologs and associated effects of Rapamycin
Targeting the mammalian target of Rapamycin pathway with everolimus: Implications for the management of metastatic breast cancer
Rapamycin can restore the negative regulatory function of transforming growth factor beta 1 in high grade lymphomas
… of long‐chain acyl‐CoA synthetase isoform 1 impairs cardiac autophagy and mitochondrial structure through mechanistic target of Rapamycin complex 1 activation
Glucocorticoids retard skeletal muscle development and myoblast protein synthesis through a mechanistic target of Rapamycin (mTOR)-signaling pathway in broilers …
… first‐line pazopanib therapy followed by vascular endothelial growth factor receptor tyrosine kinase inhibitors or mammalian target of Rapamycin inhibitors: a single …
Evaluating the effect of 20-hydroxyecdysone (20HE) on mechanistic target of Rapamycin complex 1 (mTORC1) signaling in the skeletal muscle and liver of rats
Mammalian target of Rapamycin inhibitor–associated stomatitis in hematopoietic stem cell transplantation patients receiving sirolimus prophylaxis for graft …
Rapamycin (Sirolimus) alters mechanistic target of Rapamycin pathway regulation and microRNA expression in mouse meiotic spermatocytes
Rapamycin ameliorates chitosan nanoparticle-induced developmental defects of preimplantation embryos in mice
The Akt/mTOR/p70S6K pathway is activated in IgA nephropathy and Rapamycin may represent a viable treatment option
Increase of microRNA-210, decrease of raptor gene expression and alteration of mammalian target of Rapamycin regulated proteins following mithramycin …
Slow-releasing Rapamycin-coated bionic peripheral nerve scaffold promotes the regeneration of rat sciatic nerve after injury
Differential expression of GAS 5 in Rapamycin‐induced reversion of glucocorticoid resistance
Rapamycin targets Interleukin 6 (IL-6) expression and suppresses endothelial cell invasion stimulated by tumor cells
Klotho upregulation by Rapamycin protects against vascular disease in CKD
Pharmacokinetics of orally administered low-dose Rapamycin in healthy dogs
Reduction of intraarticular adhesion of knee by local application of Rapamycin in rabbits via inhibition of fibroblast proliferation and collagen synthesis
… and cancer stem-like cell properties via the vascular endothelial growth factor (VEGF)/phosphatidylinositol 3-kinase (PI3K)/Akt/mechanistic target of Rapamycin …
Anticancer mammalian target of Rapamycin (mTOR) signaling pathway inhibitors: current status, challenges and future prospects in management of epilepsy
… contributes to early oligodendrocyte progenitor proliferation by activating phosphatidylinositol 3-kinase (PI3K)/AKT and the mammalian target of Rapamycin (mTOR) …
Curcumin attenuates Rapamycin-induced cell injury of vascular endothelial cells
Formulation and characterization of a 0.1% Rapamycin cream for the treatment of Tuberous Sclerosis Complex-related angiofibromas
Potential role for mammalian target of Rapamycin inhibitors as first-line therapy in hormone receptor–positive advanced breast cancer
Mammalian target of Rapamycin is required for phrenic long-term facilitation following severe but not moderate acute intermittent hypoxia
inhibition of insulin-like growth factor receptor/AKT/mammalian target of Rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate …
A treadmill exercise reactivates the signaling of the mammalian target of Rapamycin (mTOR) in the skeletal muscles of starved mice
The pan phosphoinositide 3-kinase/mammalian target of Rapamycin inhibitor SAR245409 (voxtalisib/XL765) blocks survival, adhesion and proliferation of primary …
… peptide-2 on the tight junction and barrier function in IPEC-J2 cells through phosphatidylinositol 3-kinase–protein kinase B–mammalian target of Rapamycin …
Protein kinase FgSch 9 serves as a mediator of the target of Rapamycin and high osmolarity glycerol pathways and regulates multiple stress responses and secondary …
Manganese-stimulated kisspeptin is mediated by the IGF-1/Akt/mammalian target of Rapamycin pathway in the prepubertal female rat
Anticancer effect of Rapamycin on MCF-7 via downregulation of VEGF expression
… -2-decenoic acid, the major lipid component of royal jelly, extends the lifespan of Caenorhabditis elegans through dietary restriction and target of Rapamycin …
Immunohistochemical analysis of phosphorylated mammalian target of Rapamycin and its downstream signaling components in invasive breast cancer
… factor induces autophagy to resist hypoxia/serum deprivation‑induced apoptosis via the AMP‑activated protein kinase/mammalian target of Rapamycin …
Rapamycin impairs HPD‐induced beneficial effects on glucose homeostasis
Effects of mammalian target of Rapamycin inhibitors on cytokine production and differentiation in keratinocytes
Factors influencing the central nervous system distribution of a novel phosphoinositide 3-kinase/mammalian target of Rapamycin inhibitor GSK2126458: implications …
Regulation of cardiac miR‐208a, an inducer of obesity, by Rapamycin and nebivolol
A pilot, single arm, prospective trial using neoadjuvant Rapamycin prior to definitive therapy in head and neck squamous cell carcinoma.
inhibition of mTOR by Rapamycin results in auditory hair cell damage and decreased spiral ganglion neuron outgrowth and neurite formation in vitro
Target of Rapamycin (TOR) in Fenneropenaeus chinensis: cDNA cloning, characterization, tissue expression and response to amino acids
Targeted inhibition of phosphoinositide 3-kinase/mammalian target of Rapamycin sensitizes pancreatic cancer cells to doxorubicin without exacerbating cardiac toxicity
Rapamycin inhibits the proliferation of SW1990 pancreatic cancer cell
Rapamycin restores p14, p15 and p57 expression and inhibits the mTOR/p70S6K pathway in acute lymphoblastic leukemia cells
Rapamycin release study of porous poly (L-lactic acid) scaffolds, prepared via coaxial electrospinning
Activation of autophagy by Rapamycin does not protect oligodendrocytes against protein aggregate formation and cell death induced by proteasomal inhibition
… inhibition of tumor necrosis factor-alpha-stimulated pro-inflammatory cytokine expression in HaCaT cells by a combination of Rapamycin and mycophenolic acid
Systemic Rapamycin to prevent in-stent stenosis in peripheral pulmonary arterial disease: early clinical experience
Characterization of the Rapamycin-inducible EBV LMP1 activation system
… antitumoral properties and renal-associated tissue damage induced by tacrolimus and mammalian target of Rapamycin inhibitors in hepatocarcinoma: in vitro …
Mammalian Target of Rapamycin Inhibitors and Nephrotoxicity: Fact or Fiction.
HIF-1α and Rapamycin act as gerosuppressant in multiple myeloma cells upon genotoxic stress
inhibition of the mammalian target of Rapamycin complex 1 signaling pathway reduces itch behaviour in mice
Rapamycin ameliorates the CTLA4‐Ig–mediated defect in CD8+ T cell immunity during gammaherpesvirus infection
inhibition of mammalian target of Rapamycin activation in the rostral anterior cingulate cortex attenuates pain-related aversion in rats
… Factor Beta 1 Induced Myofibroblast Differentiation via the Phosphorylated-Phosphatidylinositol 3-Kinase Mammalian Target of Rapamycin Signal Pathways in Nasal …
Aschantin targeting on the kinase domain of mammalian target of Rapamycin suppresses epidermal growth factor-induced neoplastic cell transformation
Up-regulation of the excitatory amino acid transporters EAAT1 and EAAT2 by mammalian target of Rapamycin
Stereoselective synthesis of Rapamycin fragment to build a macrocyclic toolbox
Rapamycin increases grip strength and attenuates age-related decline in maximal running distance in old low capacity runner rats
Rapamycin up-regulates triglycerides in hepatocytes by down-regulating Prox1
The regulatory T cell effector molecule fibrinogen‐like protein 2 is necessary for the development of Rapamycin‐induced tolerance to fully MHC‐mismatched murine …
Importance of EEG in validating the chronic effects of drugs: Suggestions from animal models of epilepsy treated with Rapamycin
The effect of mammalian target of Rapamycin versus calcineurin inhibitor–based immunosuppression on measured versus estimated glomerular filtration rate after …
inhibition of wild‐type p53‐induced phosphatase 1 promotes liver regeneration in mice by direct activation of mammalian target of Rapamycin
MicroRNA-761 inhibits Angiotensin II-induced vascular smooth muscle cell proliferation and migration by targeting mammalian target of Rapamycin
Targeted therapy of colorectal neoplasia with Rapamycin in peptide-labeled pegylated octadecyl lithocholate micelles
Rapamycin causes growth arrest and inhibition of invasion in human chondrosarcoma cells
Role of mechanistic target of Rapamycin (mTOR) in renal function and ischaemia–reperfusion induced kidney injury
Clinically-relevant cyclosporin and Rapamycin concentrations enhance regulatory T cell function to a similar extent but with different mechanisms: an in-vitro study in …
Effects of slow-release urea and rumen-protected methionine and histidine on mammalian target of Rapamycin (mTOR) signaling and ubiquitin proteasome …
Rapamycin‐induced hypoxia inducible factor 2A is essential for chondrogenic differentiation of amniotic fluid stem cells
Tumor Progression Locus 2 (Tpl2) activates the mammalian target of Rapamycin (mTOR) pathway, inhibits forkhead box P3 (FoxP3) Expression, and limits …
Pubertal development in pediatric kidney transplant patients receiving mammalian target of Rapamycin inhibitors or conventional immunosuppression
Rapamycin as novel treatment for refractory-to-standard-care slow-flow vascular malformations
Contribution of mammalian target of Rapamycin in the pathophysiology of cirrhotic cardiomyopathy
Possible activation by the green tea amino acid theanine of mammalian target of Rapamycin signaling in undifferentiated neural progenitor cells in vitro
inhibition of mammalian target of Rapamycin complex 1 (mTORC1) downregulates ELOVL1 gene expression and fatty acid synthesis in goat fetal fibroblasts
… and hyperlipidemia in patients with advanced cancer receiving combination treatment with the mammalian target of Rapamycin inhibitor temsirolimus and …
Rapamycin-resistant and torin-sensitive mTOR signaling promotes the survival and proliferation of leukemic cells
Lack of benefits of mammalian target of Rapamycin inhibitor in patients transplanted for hepatocellular carcinoma: Is this the end of the story?
The efficacy and safety of mammalian target of Rapamycin inhibitors ab initio after liver transplantation without corticosteroids or induction therapy
In silico analysis of conformational changes induced by normal and mutation of macrophage infectivity potentiator catalytic residues and its interactions with Rapamycin
… of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of Rapamycin (mTOR) and impaired …
Synergism between the mTOR inhibitor Rapamycin and FAK down-regulation in the treatment of acute lymphoblastic leukemia
inhibition of galectin-1 sensitizes HRAS-driven tumor growth to Rapamycin treatment
A signal-on fluorosensor based on quench-release principle for sensitive detection of antibiotic Rapamycin
Two crystal structures of the FK506-binding domain of Plasmodium falciparum FKBP35 in complex with Rapamycin at high resolution
Rapamycin inhibits expression of elongation of very-long-chain fatty acids 1 and synthesis of docosahexaenoic acid in bovine mammary epithelial cells
Rapamycin combined with immature dendritic cells attenuates obliterative bronchiolitis in trachea allograft rats by regulating the balance of regulatory and effector T …
An efficient method to generate gene deletion mutants of the Rapamycin-producing bacterium Streptomyces iranensis HM 35
Are invertebrates relevant models in ageing research? Focus on the effects of Rapamycin on TOR
Ileal neuroendocrine tumors show elevated activation of mammalian target of Rapamycin complex
Activation of extracellular regulated kinase and mechanistic target of Rapamycin pathway in focal cortical dysplasia
Use of mammalian target of Rapamycin inhibitors after failure of tyrosine kinase inhibitors in patients with metastatic renal cell carcinoma undergoing hemodialysis: A …
Resveratrol Potentiates Growth Inhibitory Effects of Rapamycin in PTEN-deficient Lipoma Cells by Suppressing p70S6 Kinase Activity
Mechanistic target of Rapamycin is activated in bovine granulosa cells after LH surge but is not essential for ovulation
Insulin-like growth factor 1/mammalian target of Rapamycin and AMP-activated protein kinase signaling involved in the effects of metformin in the human endometrial …
Rapamycin-associated lymphoedema in an infant with Kasabach-Merritt phenomenon
Selective tuberous sclerosis complex 1 gene deletion in smooth muscle activates mammalian target of Rapamycin signaling and induces pulmonary hypertension
Effect of imatinib mesylate and Rapamycin on the preformed intimal hyperplasia in rat carotid injury model
Effect of the dual phosphatidylinositol 3‑kinase/mammalian target of Rapamycin inhibitor NVP‑BEZ235 against human Merkel cell carcinoma MKL‑1 cells
Effects of intrathecal injection of Rapamycin on pain threshold and spinal cord glial activation in rats with neuropathic pain
Phase 1b study of the mammalian target of Rapamycin inhibitor sirolimus in combination with nanoparticle albumin–bound paclitaxel in patients with advanced solid …
Cell synchronization by Rapamycin improves the developmental competence of porcine SCNT embryos
Rapamycin-conditioned dendritic cells induced immune tolerance through the regulation of Treg/Th17 cells in mice
The regulation of autophagy in porcine blastocysts: Regulation of PARylation-mediated autophagy via mammalian target of Rapamycin complex 1 (mTORC1) signaling
The mammalian target of Rapamycin complex 1 (mTORC1) in breast cancer: the impact of oestrogen receptor and HER2 pathways
Combination therapy of intraperitoneal Rapamycin and convection-enhanced delivery of nanoliposomal CPT-11 in rodent orthotopic brain tumor xenografts
Rapamycin protects against neuronal death and improves neurological function with modulation of microglia after experimental intracerebral hemorrhage in rats
Intracrine steroid production and mammalian target of Rapamycin pathways in pulmonary lymphangioleiomyomatosis
Torin2 potentiates anticancer effects on adult T-cell leukemia/lymphoma by inhibiting mammalian target of Rapamycin
Role of Ragulator in the regulation of mechanistic target of Rapamycin signaling in podocytes and glomerular function
Rapamycin enhanced the antitumor efficacy of oxaliplatin in cisplatin-resistant ovarian cancer cells A2780cis both in vitro and in vivo
Corosolic acid enhances 5‑fluorouracil‑induced apoptosis against SNU‑620 human gastric carcinoma cells by inhibition of mammalian target of Rapamycin
Effectiveness of inhibitor Rapamycin, saracatinib, linsitinib and JNJ-38877605 against human prostate cancer cells
Dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor NVP-BEZ235 synergizes with chloroquine to induce apoptosis in embryonal …
Mammalian target of Rapamycin inhibition after solid organ transplantation: can it, and does it, reduce cancer risk?
Down‐regulation of mitogen‐activated protein kinases and nuclear factor‐κB signaling is involved in Rapamycin suppression of TLR2‐induced inflammatory response …
PP242 suppresses bladder cancer cell proliferation and migration through deactivating the mammalian target of Rapamycin complex 2/AKT1 signaling …
Enhanced antitumor activity of 3-bromopyruvate in combination with Rapamycin in vivo and in vitro
Preparation and experimental research into retrievable Rapamycin-and heparin-coated vena cava filters: a pilot study
Delayed reendothelialization with Rapamycin is rescued by the addition of nicorandil in balloon-injured rat carotid arteries
Mammalian target of Rapamycin/p70 ribosomal S6 protein kinase signaling is altered by sevoflurane and/or surgery in aged rats
Rapamycin attenuates palmitate-induced lipid aggregation by up-regulating sirt-1 signaling in AML12 hepatocytes
Direct implantation of Rapamycin-eluting stents with bioresorbable drug carrier technology utilising the Svelte coronary stent-on-a-wire: the DIRECT II study
Regulation of human trophoblast GLUT3 glucose transporter by mammalian target of Rapamycin signaling
… of bone loss with the upregulation of survival-related genes and concomitant downregulation of Mammalian target of Rapamycin and osteoblast differentiation …
The imidazo [1, 2-a] pyridine ring system as a scaffold for potent dual phosphoinositide-3-kinase (PI3K)/mammalian target of Rapamycin (mTOR) inhibitors
Frameshift mutations in mammalian target of Rapamycin pathway genes and their regional heterogeneity in sporadic colorectal cancers
Synthesis of Rapamycin Derivatives Containing the Triazole Moiety Used as Potential mTOR‐Targeted Anticancer Agents
Fatigue with vascular endothelial growth factor receptor tyrosine kinase inhibitors and mammalian target of Rapamycin inhibitors in patients with renal cell carcinoma …
mTOR inhibition by Rapamycin increases ceramide synthesis by promoting transforming growth factor‐β1/Smad signaling in the skin
Effects of Rapamycin treatment on pancreatic fibrosis, cellular apoptosis and oxidative stress in experimental chronic pancreatitis model
PC-1/PrLZ confers resistance to Rapamycin in prostate cancer cells through increased 4E-BP1 stability
In vitro interactions between target of Rapamycin kinase inhibitor and antifungal agents against Aspergillus species
Topical mTOR (mechanistic target of Rapamycin) inhibitor therapy in facial angiofibroma
Design, synthesis and biological evaluation of novel Rapamycin benzothiazole hybrids as mTOR targeted anti-cancer agents
Extracellular signal–regulated kinase–mammalian target of Rapamycin signaling and forkhead-box transcription factor 3a phosphorylation are involved in …
Cell cycle status dictates effectiveness of Rapamycin
Recognition and management of oral mucosal injury caused by mammalian target of Rapamycin inhibitors: a case series
The 4E-BP1/eIF4E ratio is a determinant for Rapamycin response in esophageal cancer cells
Use of topical Rapamycin in facial angiofibromas in Indian skin type
Blocking mammalian target of Rapamycin alleviates bladder hyperactivity and pain in rats with cystitis
Rapamycin prevents acute dendritic injury following seizures
Oxaliplatin-Rapamycin combination was superior to mono-drug in treatment of hepatocellular carcinoma both in vitro and in vivo.
Rapamycin decreases the osteogenic response in aortic valve interstitial cells through the stat3 pathway
Pathological findings of a subependymal giant cell astrocytoma following treatment with Rapamycin
Restoration of normal cerebral oxygen consumption with Rapamycin treatment in a rat model of autism–tuberous sclerosis
Gene expression in the liver of female, but not male mice treated with Rapamycin resembles changes observed under dietary restriction
Protective effects of Rapamycin induced autophagy on acute kidney injury induced by sepsis
… receptor 2 and downstream pathways of receptor tyrosine kinases involving phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin or mitogen-activated …
4D MRI of polycystic kidneys from Rapamycin‐treated Glis3‐deficient mice
The mammalian target of Rapamycin signaling pathway regulates myocyte enhancer factor‐2C phosphorylation levels through integrin‐linked kinase in goat skeletal …
Mammalian‐target of Rapamycin inhibition with temsirolimus in myelodysplastic syndromes (MDS) patients is associated with considerable toxicity: results of the …
Rapamycin decreases irradiation-induced hematopoietic system damage
Conversion from calcineurin inhibitors to mammalian target-of-Rapamycin inhibitors in heart transplant recipients: a meta-analysis of randomized controlled trials
Mechanistic target of Rapamycin modulation: an emerging therapeutic approach in a wide variety of disease processes
The dynamics of histone H2A ubiquitination in HeLa cells exposed to Rapamycin, ethanol, hydroxyurea, ER stress, heat shock and DNA damage
Intracellular release of Rapamycin from poly (lactic acid) nanospheres modifies autophagy
Chronic Rapamycin treatment exacerbates metabolism and does not down-regulate mTORC2/Akt signaling in diabetic mice induced by high-fat diet and streptozotocin
A case of esophageal adenocarcinoma on long‐term Rapamycin monotherapy
Early and delayed intervention with Rapamycin prevents NNK-induced lung adenocarcinoma in A/J mice
The effect of Rapamycin on TGFβ1 and MMP1 expression in a rabbit model of urethral stricture
Effects of Rapamycin induced cellular autophagy in aging-related diseases
Rapamycin slows down gut aging
Rapamycin in the treatment of cardiac rhabdomyoma associated with tuberous sclerosis complex
miR-144 regulates BCG-and Rapamycin-induced autophagy by targeting Atg4a in RAW264. 7 cells
Joining forces: first application of a Rapamycin‐induced dimerizable Cre system for conditional null mutant analysis in Leishmania
Additive effects of Rapamycin and aspirin on dendritic cell allostimulatory capacity
Rapamycin-conditioned dendritic cells activated with monophosphoryl lipid-A promote allograft acceptance in vivo
The yeast ζ‐crystallin/NADPH: quinone oxidoreductase (Zta1p) is under nutritional control by the target of Rapamycin pathway and is involved in the regulation of …
Role of Mammalian Target of Rapamycin (mTOR) in Cardiac Homeostasis in Metabolic Disorders
Effect of nourishing “yin” removing “fire” Chinese herbal mixture on hypothalamic mammalian target of Rapamycin expression during onset of puberty in female …
Effect of Rapamycin (RAPA) on the growth of lung cancer and its mechanism in mice with A549
Mammalian target of Rapamycin (mTOR) activity promotes neuronal survival in stroke with or without ischemic postconditioning
Overexpression of TOR (target of Rapamycin) inhibits cell proliferation in Dictyostelium discoideum
… and activator of transcription 3 (JAK2/STAT3) signaling pathway in pancreatic acinar cells in rats, while AG490 and Rapamycin inhibit their activation
Protective effects of low-dose Rapamycin combined with valsartan on podocytes of diabetic rats
Mammalian target of Rapamycin inhibitor monotherapy: efficacy in renal transplantation
Activation of the mammalian target of Rapamycin in the rostral ventromedial medulla contributes to the maintenance of nerve injury-induced neuropathic pain …
Rapamycin improves mortality following intestinal ischemia-reperfusion via the inhibition of remote lung inflammation in mice
Effect of Rapamycin on the balance of T helper cell subsets in rats with pulmonary fibrosis
Protective effect of silymarin against Rapamycin-induced apoptosis and proliferation inhibition in endothelial progenitor cells
Efficacy and toxicity of mammalian target Rapamycin inhibitors in patients with metastatic renal cell carcinoma with renal insufficiency: the Korean Cancer …
Efficacy and mechanism of local delivery of Rapamycin and Rapamycin-loaded poly (lactic-co-glycolic) acid nanoparticles on coronary restenosis of injury-stenosis …
Topical Rapamycin combined with pulsed dye laser (PDL) in the treatment of capillary vascular malformations—Anatomical differences in response to PDL are relevant …
Serendipity in splendid isolation: Rapamycin
Brain size is controlled by the mammalian target of Rapamycin (mTOR) in mice
4E-BP2 hardwires lymphocytes for Rapamycin sensitivity
Effects of mechanistic target of Rapamycin signaling pathway on the estrogen-mediated NaPi-IIb protein expression in pig small intestinal epithelial cells
Natural killer group 2D and CD28 receptors differentially activate mammalian/mechanistic target of Rapamycin to alter murine effector CD8+ T‐cell differentiation
Activation of Mammalian target of Rapamycin in canine mammary carcinomas: an immunohistochemical study
Rapamycin as a Potential Treatment for Obesity
Rapamycin does not impede survival or induction of antibody responses to primary and Heterosubtypic influenza infections in mice
… -Kuey-Jian-Tang induces autophagy in HepG2 cells via regulation of the phosphoinositide-3 kinase/Akt/mammalian target of Rapamycin and p38 mitogen …
CWF-145, a novel synthetic quinolone derivative exerts potent antimitotic activity against human prostate cancer: Rapamycin enhances antimitotic drug-induced …
Mammalian target of Rapamycin (mTOR), aging, neuroscience, and their association with aging-related diseases
Understanding the cellular impact of low dose Rapamycin treatment.
Tumor cell-derived secretory factor downregulates Semaphorin-3a in osteoblasts by activating mammalian target of Rapamycin pathway
Mammalian target of Rapamycin inhibitor induced complete remission of a recurrent subependymal giant cell astrocytoma in a patient without features of tuberous …
Rapamycin reverse lipopolysaccharide-induced acute lung injury through acti-vating autophagy flux
Regulation of hypoxia-inducible factor-1α, regulated in development and DNA damage response-1 and mammalian target of Rapamycin in human placental BeWo …
Phase II trial of gemcitabine plus Rapamycin as second line in advanced osteosarcoma: A Spanish Group for Sarcoma Research (GEIS) Study.
Combined antitumor gene therapy with herpes simplex virus-thymidine kinase and short hairpin RNA specific for mammalian target of Rapamycin
Preventive and therapeutic effects of Rapamycin against autoimmune hepatitis and liver fibrosis and possible mechanisms
Rapamycin enhances IFN-γ and IL-4 production in co-culture of gδ T and dendritic cells from mice with lipopolysaccharide-induced acute lung injury
Expression of Concern. A Central Role for Neuronal AMP-Activated Protein Kinase (AMPK) and Mammalian Target of Rapamycin (mTOR) in High-Protein Diet …
Topical Rapamycin for angiofibromas in patients with tuberous sclerosis: how does it work in clinical practice?
Dual inhibition of phosphatidylinositol 3-kinase/mammalian target of Rapamycin and mitogen activated protein kinase pathways in non-Hodgkin lymphoma
Effects of dietary soy protein concentrate on growth, digestive enzymes activities and target of Rapamycin signaling pathway regulation in juvenile soft-shelled …
Growth inhibitory effect of Rapamycin in Hodgkin-lymphoma cell lines characterized by constitutive NOTCH1 activation
Pharmacology of mammalian (mechanistic) target of Rapamycin (mTOR) inhibitors
Role of the phosphatidylinositol-3-kinase/Akt/target of Rapamycin pathway during ambidensovirus infection of insect cells
Mechanism of Polypeptide Extract from Scorpion Venom Combined Rapamycin in Enhancing Autophagy of H22 Hepatoma Cells: an Experimental Study
In vitro study of effects and mechanism of Rapamycin-induced autophagy in keloid fibroblasts
Using the mycelium-covered cereals as an efficient inoculation method for Rapamycin fermentation in a 15-L fermenter using Streptomyces hygroscopicus
Erratum to: Optimization of adipose tissue-derived mesenchymal stem cells by Rapamycin in a murine model of acute graft-versus-host disease
Rapamycin increases RSV RNA levels and survival of RSV-infected dendritic cell depending on T cell contact
Efficacy of Rapamycin therapy in the women with metastatic breast cancer in West Iran
Mechanisms for reversal of pulmonary hypertension by Rapamycin in rats
Roles of Mechanistic Target of Rapamycin in the Adaptive and Innate Immune Systems
An Analytical Approach for Insulin-like Growth Factor Receptor 1 and Mammalian Target of Rapamycin Blockades in Ewing Sarcoma
Potential future Indication of Rapamycin Analogs for the Treatment of solid Tumors
Abstract B59: Dual mTOR kinase inhibitor reverses Rapamycin resistance in prostate cancer cells
Effects of Ras homolog gene family, member C gene silencing combined with Rapamycin on hepatocellular carcinoma cell growth
A phase I/II multi-center study of intravesical nanoparticle albumin-bound Rapamycin (ABI-009) in the treatment of BCG refractory non-muscle invasive bladder cancer.
Costimulatory blockade and use of mammalian target of Rapamycin inhibitors: avoiding injury part 1
Autologous Rapamycin-Resistant T Cell Therapy of Multiple Myeloma
Association of mammalian target of Rapamycin gene polymorphisms with the risk of pediatric epilepsy
Immune-Stimulatory Effects of Rapamycin Are Mediated by Stimulation of Antitumor gd T Cells
The Effect of Rapamycin on Penicillin-Induced Epileptiform Activity in Rats: An Electrophysiological Study
PT684. Treatment with Rapamycin improves deficits of social interaction in the mice exposed in utero to valproic acid
Comparable neuroprotective effect of Rapamycin against low and high rotenone concentrations in primary dopaminergic cell culture
Enhanced antitumor activity of Rapamycin and genipin, a UCP-2 inhibitor, in lung cancer
… nephrectomy specimens as a predicting factor of progression-free survival in patients with metastatic renal cell carcinoma treated with mammalian target of Rapamycin …
Rapamycin results in Bim-mediated loss of thymic regulatory T cells during development in organ culture
Mammalian target of Rapamycin (mTOR) inhibition in advanced bronchial carcinoids
Sann-Joong-Kuey-Jian-Tang decreases the protein expression of mammalian target of Rapamycin but increases microtubule associated protein II light chain 3 …
Rapamycin protects ova induced asthma in mice through regulating autophagy
Oleuropein potently inhibits mammalian target of Rapamycin: possible involvement of tandem anomeric hyperconjugation–Michael reaction
Structural studies on the target of Rapamycin complex 1
Risk factors associated with mammalian target of Rapamycin inhibitor withdrawal in kidney transplant recipients
Rapamycin Enhances the Suppressive Capacity of Ex Vivo Expanded Regulatory T Cells (Tregs) Isolated From Pediatric Thymus
Activation of mTOR signaling pathway in cancer stem cells of nasopharyngeal carcinoma and inhibitive effect of Rapamycin against the cancer stem cells
Catalytic mammalian target of Rapamycin inhibitors as antineoplastic agents
Efficacy of Rapamycin in Tuberous Sclerosis–Associated Hypopigmented Macules: Back to the Future
Topical Rapamycin suppresses lacrimal gland inflammation in a mouse model of Sjögren’s Syndrome
Phase II study of dual phosphoinositol-3-kinase (PI3K) and mammalian target of Rapamycin (mTOR) inhibitor BEZ235 in patients with locally advanced or metastatic …
Changes of Sexual Behaviors in Rapamycin-injected Cichlid Fish Astatotilapia burtoni Males
Down-regulation of MAPKs and NF-κB Signaling is Involved in Rapamycin Suppression of
Molecular characterization and expression analysis of target of Rapamycin (TmTOR) in coleopteran insect Tenebrio molitor
Comparative proteomic analysis of Rapamycin versus cyclosporine combination treatment in mouse podocytes
The role of Rapamycin-eluted stent in vascular endothelial injury
A phase I/II study of albumin-bound Rapamycin nanoparticles in the treatment of bacillus calmette-guerin refractory non-muscle invasive transitional cell bladder cancer …
Rapamycin-topotecan combination exhibited enhanced antitumor efficacy compared to topotecan used alone in cisplatin-resistant ovarian cancer cells.
Probing mitosis by manipulating the interactions of mitotic regulator proteins using Rapamycin-inducible dimerization
Studies on the response to, and recovery from, Rapamycin in Saccharomyces cerevisiae
P-113 Mammilian target of Rapamycin (mTOR) and autophagy in hepatitis C virus-related hepatocellular carcinoma: relation to tumor progression
LB-S&T-03 A PHASE 1/2 STUDY OF ALBUMIN-BOUND Rapamycin NANOPARTICLES IN BACILLUS CALMETTE-GUERIN REFRACTORY NON-MUSCLE …
Novel insights into regulation of Target of Rapamycin Complex 2 by hyperosmotic stress.
Halofuginone synergistically enhances anti-proliferation of Rapamycin in T cells and reduces cytotoxicity of cyclosporine in cultured renal tubular epithelial …
Neuroprotective effect of Rapamycin in the retina
Rapamycin for vascular tumor/malformation
Identifying rational combination therapies with Rapamycin for the treatment of epithelial cancers
The pilot study on Rapamycin retarding the differentiation of RPE cells in vitro
… hematological disorders observed in Shwachman-Diamond syndrome: mTOR and STAT3 hyper-phosphorylation in CD4+ and CD8+ T cells and efficacy of Rapamycin …
In vivo Toll‐like receptor 5 (TLR5) imaging with radiolabeled anti‐TLR5 monoclonal antibody in Rapamycin‐treated mouse allogeneic skin transplantation model
Rapamycin and Chloroquine: The
The role of Rapamycin-eluted stent in vascular endothelial injury
Rapamycin Improves Vascular Remodeling in a Controlled Rat Model of Monocrotaline-induced Pulmonary Hypertension
Effects of leucine and histidine on milk protein synthesis via mammalian target of Rapamycin signaling pathway in the bovine mammary epithelial cells.
Effects of tetrandrine and caffeine on cell viability and expression of mammalian target of Rapamycin, phosphatase and tensin homolog, histone deacetylase 1 …
Neurotensin and Corticotropin‐releasing Hormone Synergistically Activate Human Microglia through Mammalian Target of Rapamycin Complex 1 (mTORC1)
Determination of GDC‐0980 (apitolisib), a small molecule dual phosphatidylinositide 3‐kinase/mammalian target of Rapamycin inhibitor in dog plasma by LC‐MS/MS …
Rapamycin POLYMER NANOTHERAPEUTICS FOR PULMONARY HYPERTENSION TREATMENT
FCT-14: Topical 0.2% Rapamycin for angiofibromas due to tuberous sclerosis complex (TSC)
Effect of Rapamycin on apoptosis of mouse astrocytes in vitro
Mammalian Target of Rapamycin Signaling Pathways and Depression
Serendipity in splendid isolation: Rapamycin
Regulation of Hepatic Metabolism by the Mechanistic Target of Rapamycin
Therapeutic effect of Rapamycin on the clinical and radiological aspects in patients with multiple sclerosis
Rapamycin inhibits the phosphorylation of mSin1 by targeting a new mTOR complex
Effect of Rapamycin on Proliferation and Cell Cycle of Human Bladder Carcinoma Cell Line 5637
FP471 EFFECT OF Rapamycin ON EXPRESSION OF IL17 AND TLR4 IN EARLY STAGE OF DN RATS
Structural and functional characterization of Rapamycin-resistant TORC2
Improvement of antitumor effect of ionizing radiation to treat nasopharyngeal carcinoma in combination with Rapamycin
Effects and mechanisms of Rapamycin on renal interstitial fibrosis in rats
Congenital Hyperinsulinism; Effects of Rapamycin on Min6 Pancreatic?-Cell Line
The Adjuvant Effect of Rapamycin for a New Multi-stage Subunit Vaccine Candidate LT69
Effect of Rapamycin on Expression of Survivin and Caspase-3 and Its Influence on K562 Cell Ultrastructure
Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells
The Impact of Rapamycin and Metformin on Genome Organization and Function in Normal Human Fibroblasts
Alterations of the electrophysiological properties from cortical layer 5 pyramidal neurons in temporary Rapamycin-treated rodent brain slices
The Effects of Rapamycin on the Unfolded Protein Response in Relation to Healthy Aging
The Effect of Rapamycin on Mitochondrial Electron Transport Chain (ETC) Activity and Superoxide Production
Sensitivity of esophageal squamous cell carcinoma cells to Rapamycin can be improved by siRNA-interfered expression of p70S6K
Rapamycin Activates TGF Receptor Independently of Its Ligands: Implications for Endothelial Dysfunction
Effect of Rapamycin on the migration of human epidermal cell line HaCaT and its possible molecular mechanism
Anticancer effect of Rapamycin on MCF-7 via downregulation of VEGF expression Animal
Study on Effects and Mechanism of Rapamycin on Invasion and Metastasis of Cervical Cancer HeLa Cells
Is it necessary to investigate Rapamycin-modulated autophagy during the development of experimental osteoporosis in female rat?
Dual mTOR kinase inhibitor overcomes Rapamycin resistance in vitro
Anti-fibrotic effects of Rapamycin by activation of autophagy in scarforming fibroblasts
Host Ingestion of Rapamycin Increased Nematode and Cestode Reproduction
A Novel Multiple Sclerosis Model Utilizing Cuprizone and Rapamycin
CP-173 Topical 0.1% Rapamycin for angiofibromas in a paediatric patient with tuberous sclerosis
Identification of a natural compound as mammalian target of Rapamycin kinase inhibitor
Characterization and Rapamycin Treatment Of Laryngotracheal Stenosis, In Vitro and In Vivo
Chronic mTOR inhibition by Rapamycin and Diabetes: What is the Role of Mitochondria?
Mammalian target of Rapamycin inhibitors: A paradigm shift in current immunosuppression protocols
Augmentation of nonsense mediated decay by Rapamycin
Sphingolipids mediate the signals for all the essential functions of Target Of Rapamycin Complex 2
Effect of Rapamycin on proliferation of rat heart valve interstitial cells in vitro
Rapamycin adjuvant therapy did not improve the outcome of severe influenza virus infection in an experimental mouse model system
Advance in research on the relationship between mammalian target of Rapamycin signaling pathway and ophthalmic diseases
Rapamycin expands t-regulatory cells and improves implantation and live birth rates in a murine model
Outcome of Rapamycin Therapy for Post Transplant-Lymphoproliferative Disorder after Kidney Transplantation: Case Series
Effects of Rapamycin and 3-MA on motor behavior and autophagy related protein LC3 in PD model mice
The Breeding of High-yielding Actinoplanes of Rapamycin
Changes in expression of autophagy-related proteins, Beclin-1 and LC3, and effects of Rapamycin on their expression in hypoxic-ischemic hippocampus
Enhanced antitumor activity of Rapamycin and genipin, a UCP-2 inhibitor, in lung cancer.
Rapamycin rescues the innate immune/inflammatory response in the retina of the Ndufs4 mouse
In Vivo Sustained Release of Rapamycin (Sirolimus) from a Biodegradable Intravitreal Device
Combination therapy of FK228 with Rapamycin synergistically promotes human breast cancer cell apoptosis by DNA damage and cell cycle arrest
4-(N-Phenyl-N′-substituted benzenesulfonyl)-6-(4-hydroxyphenyl) quinolines as inhibitors of mammalian target of Rapamycin
Rapamycin Induced Acute Myelogenous Leukemia U937 Cell Autophagy and Apoptosis
THE EFFECTS OF Rapamycin ON THE GLYCOLYSIS IN BREAST CANCER CELL LINES MCF-7 & MDAMB231
Sensitivity of esophageal squamous cell carcinoma cells to Rapamycin can be improved by si RNA-interfered expression of p70S6K
Efficacy of Rapamycin and paclitaxel eluting stent implantation in treatment of coronary artery disease
Investigating novel interaction partners of amyloid precursor protein: the mechanistic target of Rapamycin and pikyve complex
Small molecules as tool compounds to probe Target of Rapamycin (TOR) signaling
Effect and Mechanism of Rapamycin Inhibiting mTOR on Heart Valve Cell Calcification in Experimental Rats
Reperfusion Therapy With Rapamycin Prevents Myocardial Injury in Type 2 Diabetic Rabbits
Cardiac-specific Overactivation of the Mechanistic Target of Rapamycin Complex 1 Induces Metabolic, Structural and Functional Remodeling
Target of Rapamycin signaling mediates vacuolar fission caused by endoplasmic reticulum stress in S. cerevisiae.
Effect of Rapamycin on the Gene Expression Signature of Focal Lesions in a Model of Progenitor‐Derived HCC
Microinjection Technique to Relieve Neuropathic Pain by Infusion of Rapamycin into the Insular Cortex
Rapamycin-based macrocyclic library development and Equilibrative Nucleoside Transporter 1 (ENT1) inhibition
Abstract T P79: Rapamycin Improves Outcome Post Stroke Injury by Enhancing Autophagy in Neuronal Cells
Investigating efficacy of combinational use of Rapamycin and Valproic acid in treatment of triple negative breast cancer cells
Preparation of nearly monodispersed polycaprolactone nano-particles loaded with the immunosuppressive drug Rapamycin by membrane micromixing …
Rapamycin Treatment Regulates miRNAs Associated With Mitochodrial and Endoplasmic Reticulum Functions in a Pig Model of Miocardial Ischemia-reperfusion …
Rapamycin Regulates Autophagy and Cell Adhesion in Induced Pluripotent Stem Cells
Rapamycin in combination with gemcitabine reduced viability, growth and metastasis of the murine osteosarcoma cell line LM8 in vitro and in vivo
Characterizing the Mechanistic Target of Rapamycin Complex 2 Pathway in Glioblastoma Multiforme
Role of hippocampal mammalian target of Rapamycin signaling pathway in inflammatory pain in rats
Impact of autophagy on allorejection and underlying mechanisms in Rapamycin-treated allotransplantation model
Molecular mechanism of amino acids in regulation of mammalian target of Rapamycin complex 1 signaling pathway.
Research progress of mammalian target of Rapamycin and hypoxia-inducible factor-1 in malignant tumors
Topical Rapamycin Therapy to Alleviate Cutaneous Manifestations of Tuberous Sclerosis Complex
Inhibiting the mammalian target of Rapamycin as an adjunctive therapy for cerebral malaria (MPF7P. 714)
Effects of Rapamycin on expression of six kinds miRNAs in RAW264. 7 macrophages and research on miR-20a’s targeted regulation of ATG16L1 gene expression
Linking Metabolic and Structural Remodeling by Cardiac‐Specific Activation of the Mechanistic Target Of Rapamycin Complex 1
Microencapulated Rapamycin prevents carcinogen and inflammation driven colon cancer through immune mechanisms
Rapamycin-and paclitaxel-eluting stents for prevention of cardiovascular events: effectiveness and safety
Mammalian target of Rapamycin inhibition with enterically given Rapamycin alters immunity and gut flora in young and aged wild type mice and extends life of …
Evolution of disease activity and biomarkers on and off Rapamycin in 28 patients with autoimmune lymphoproliferative syndrome
Rapamycin-INDUCED RESCUE OF AUTOPHAGY DRIVES GLIOBLASTOMA STEM/PROGENITOR CELLS DIFFERENTIATION
Rapamycin Prevents Bronchiolitis Obliterans through Increasing Regulatory B Cells Infiltration in A Murine Tracheal Transplantation Model
Environmental Signaling through the Target of Rapamycin Complex 1 (TORC1) and the Regulation of Epigenetic Mechanisms
Rapamycin Blocks a Key Thermogenesis Pathway in White Adipose Tissue: Diabetes/Obesity Implications
Rapamycin Reverses Lymphatic Abnormalities In A Transgenic Mouse Model Of Pulmonary Lymphangiectasia
Immunofluorescent approaches to investigate the mammalian target of Rapamycin (mTOR) complex in human skeletal muscle
Rapamycin Is Highly Effective in a Mouse Model of Immune-Mediated Bone Marrow Failure By Mechanisms Distinct from Cyclosporine
Th1, Th2 and Th17 cytokine profile in patients with multiple sclerosis following treatment with Rapamycin
A Novel Compound Tanshinol Prolongs Cardiac Allograft Survival Induced by Rapamycin
Estimates in several industrial yeast strains ploidy by flow cytometer with Rapamycin.
Study of the effect of Rapamycin on mTOR complex using capillary isoelectric focusing coupled with laser induced fluorescence-detector
Drug Development against Rapamycin-resistant Cancers via Leucyl-tRNASynthetase
Assessing efficacy of combinational therapy of Rapamycin and Tamoxifen on estrogen receptor positive MCF7 breast cancer cells
Topical Rapamycin treatment is effective in hypopigmented macules of tuberous sclerosis
The influence of the Target of Rapamycin (TOR) on starch metabolism in Arabidopsis thaliana
Rapamycin treatment of normal human fibroblasts increases the transcriptional abundance of genes involved in cytokine-cytokine receptor signalling
D44 FIRST LINE OF DEFENSE: AIRWAY RESPONSE TO INFECTIONS AND IRRITANTS: Rapamycin Protects Ova Induced Asthma In Mice Through Regulating …
Anti‑migratory effect of Rapamycin impairs allograft imaging by 18F‑fluorodeoxyglucose‑labeled splenocytes
GW27-e0513 inhibition of mammalian target of Rapamycin complex 1 protects against reperfusion injury in heart through STAT3 signaling
Rapamycin Preferentially Inhibits IL5+ Th2 Cell Proliferation through the mTORC1/S6 Kinase Pathway
Abstract B055: The impact of Rapamycin and tacrolimus treatment on resident CD8+ T-cell populations in cutaneous squamous cell carcinoma
Abstract T P85: Mammalian Target of Rapamycin (mTOR) Signaling Pathway Mediates Cerebral Ischemic Brain Damage
GW27-e0035 Delayed reendothelialization with Rapamycin is rescued by the addition of nicorandil in balloon-injured rat carotid arteries
Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes Molecular and cell biology of lipids
Mammalian target of Rapamycin inhibitors are promising T cell lymphoma treatment agents that synergize with ERβ agonists in vitro but not in vivo (VAC3P. 1061)
Protective role and the mechanism of Rapamycin against concanavalin A (ConA) induced autoimmune hepatitis in mice
The Evolving Role of Mammalian Target of Rapamycin (mTOR) Inhibitors in Renal Cell Carcinoma
Confirmation Of The Cellular Targets Of Benomyl And Rapamycin And Studies Into The Mode Of Action Of Cationic Amphiphilic Drugs (CADs)
Binge Drinking With Protein Kinase C Epsilon: A Role for Mammalian Target of Rapamycin Complex 2?
Rapamycin Treatment Inhibits the Progression of Optic Neuritis Mediated Visual Loss in Experimental Autoimmune Encephalomyelitis (EAE) Mice
The Role of Protein Kinase C in Mammalian Target of Rapamycin Signaling and its Therapeutic Implications in Non-Small Cell Lung Cancer
Cell synchronization by Rapamycin improves the developmental competence of porcine SCNT embryos
Mammalian target of Rapamycin inhibitors against hepatocellular carcinoma recurrence after liver transplantation
Reperfusion Therapy With Rapamycin Prevents Myocardial Injury by Induction of Cardiac MicroRNA-302a in Diabetic Rabbits
Effects of Rapamycin on amyloid β-protein induced impairments of working memory and synaptic plasticity in rats
Specificity to capture endothelial progenitor cells in the peripheral blood by CD34 antibody applied on a Rapamycin eluting stent
inhibition of glucose metabolism in neuroendocrine tumors by lanreotide, sunitinib, and Rapamycin
Effects of Rapamycin and Rapamycin-loaded Poly (lactic-co-glycolic) Acid Nanoparticles on Apoptosis and Expression of bcl-2 and p27 (kip1) Proteins of Human …
Differential Roles of Mammalian Target of Rapamycin (mTOR) in Phrenic Long‐Term Facilitation
Abstract B12: Rapamycin-induced miR-21 promotes the survival of mTORC1 hyperactivated cells in tuberous sclerosis complex models
Rapamycin Increases the Thrombogenic Potential of Neutrophil Extracellular Traps (NETs): Potential Mechanism of Prothrombotic Drug-Eluting Stents
Modulation of mTOR and p53 signaling using Rapamycin plus CP-31398 inhibits growth and progression of urothelial carcinoma in-vivo
Reperfusion Therapy with Rapamycin Prevents Myocardial Injury and restores Plasma Levels of Stress‐Sensitive microRNA‐191 in Conscious Diabetic Rabbits
Rapamycin, an evolving role in up-regulation of autophagy to improve stroke outcome and increase neuronal survival to stroke type injuries
Effect of Electro-acupuncture on Mammalian Target of Rapamycin Expression in Hypoxic-ischemic Encephalopathy Newborn Rats
Rapamycin enhances Sox9 expression during chondrogenic differentiation of amniotic fluid stem cells
Short-term prognostic implication for patients with ST-elevation myocardial infarction undergoing domestic Rapamycin drug-eluting stent implantation
The Role of Hypoxia on Pyruvate Kinase M2, mammalian Target of Rapamycin, Mitochondrial Function, and Cell Invasion in the Trophoblast
Rapamycin ameliorates experimental autoimmune uveoretinitis by inhibiting Th1/Th2/Th17 cells and upregulating CD4+ CD25+ Foxp3 regulatory T cells
Mammalian target of Rapamycin is required for axon growth of adult dorsal root ganglion neurons
Rrd1p, an RNA Polymerase II‐specific Prolyl Isomerase and Activator of Phosphoprotein Phosphatase, Promotes Transcription Independently of Rapamycin …
Rapamycin Protects Diabetic Heart Against Ischemia-reperfusion Injury by Inhibiting JNK and STAT4
Effects of Mammalian Target of Rapamycin inhibition on Circuitry Changes in the Dentate Gyrus of Mice after Focal Brain Injury
Rapamycin ameliorates ethambutol induced toxic optic neuropathy by facilitating mitophagy
Renal angiomyolipomas, Tuberous Sclerosis Complex and mammalian target of Rapamycin inhibitors
Insulin stimulates retinal ganglion cell dendrite regeneration through activation of the mammalian target of Rapamycin complex 1and complex 2
Reperfusion Therapy With Rapamycin Prevents Myocardial Ischemic Injury, Through Activation of AKT and ERK
Selective TSC1 deletion in smooth muscle results in mTOR signaling activation and development of pulmonary hypertension that can be reversed by Rapamycin
Alteration of mammalian target of Rapamycin signaling pathways in an In Vitro model of repetitive mild traumatic brain injury
DNA methyltransferase expression and proliferation status of metastatic breast cancer cell line after prolonged and repeated Rapamycin and melatonin application
Adopting the Rapamycin trapping assay to track the trafficking of murine MHC class I alleles, H-2K b
Positive expression of phosphorylated mammalian target of Rapamycin in gastric caner and its clinicopathological and prognostic significance: a meta analysis
Lipophilic bisphosphonates plus Rapamycin: a deadly combination for KRAS-mutated lung adenocarcinoma
Preparation of Rapamycin and methyl-β-cyclodextrin complexes using a single-step, organic solvent-free supercritical fluid process: An approach to enhance the …
Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down’s syndrome
Evaluation of Rapamycin for the Treatment of Autoimmune-Mediated Dry Eye in a Mouse Model of Sjögren’s Syndrome
The role of amino acid-induced mammalian target of Rapamycin complex 1 (mTORC1) signaling in insulin resistance
B62 THE BIOLOGY OF SCARRING. WHERE ARE WE NOW: Rapamycin Insensitive mTOR Signalling Promotes Tgf-[Beta] Induced Pro-Fibrotic Gene Expression In …
Diazoxide preconditioning is mediated by mechanistic target of Rapamycin (mTOR) and S6 Kinase (S6K)
Rapamycin Insensitive mTOR Signalling Promotes TGF-β Induced Pro-Fibrotic Gene Expression In Human Lung Fibroblasts
AME is a Mammalian Target of Rapamycin kinase inhibitor on EGF-induced neoplastic cell transformation
B52 NEONATAL LUNG DISEASE: FROM BENCH TO BABIES: Rapamycin Reverses Lymphatic Abnormalities In A Transgenic Mouse Model Of Pulmonary …
Comment on retinal ganglion cell electrical activity, mammalian target of Rapamycin signaling and optic nerve regeneration
Rapamycin directly inhibits T cell lymphoma proliferation at high doses and facilitates immune-independent toxin-mediated killing at a low dose in vivo.
In vivo Rapamycin-treated mouse allogeneic transplanted skin imaging with radiolabeled anti-Toll-like receptor 5 (TLR5) mAb
Role of Mammalian Target of Rapamycin (mTOR) Signalling in BeWo Trophoblast Differentiation and Fusion
AKT inhibition sensitizes tumor cells to Rapamycin by enhancing the repressive function of PRS40 on mTORC1/4E-BP1 axis
Expressions of the key proteins of the protein kinase B/mammalian target of Rapamycin signaling pathway in skin tissue and wound tissue of diabetic rats
Control of cell fate by the mammalian target of Rapamycin (mTOR) under stress depends on eIF2α serine 51 phosphorylation
Crucial Role of the Mammalian Target of Rapamycin (mTOR) in Activation of Human Microglia, Mast Cells and Keratinocytes, Inhibitable by Methoxyluteolin
Differentiation therapy of the neoplastic stromal cells in giant cell tumor of bone using the US Food and Drug Administration (FDA)-approved drugs, Rapamycin …
Effects of hydrogen-rich saline on hippocampal mammalian target of Rapamycin/tau pathway after operation in aged rats
A Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin, GSK2126458, Inhibits Laser-Induced Choroidal Neovascularization
Altered electrolyte homeostasis in mice with collecting‐duct‐principal‐cell select knockout of the mammalian‐target‐of‐Rapamycin (mTOR)
MP39-09 Rapamycin INHIBITS FLCN-DEFICIENT RENAL TUMOR GROWTH IN MICE
Haploidentical Peripheral Blood Stem Cell Transplantation after Treosulfan-Based Conditioning and Rapamycin GvHD Prophylaxis in Hodgkin Lymphoma
Rapamycin and retinoic acid downregulate the methylation of FoXP3 after restimulation in human treg derived from naive t cells
Fatigue with vascular endothelial growth factor receptor tyrosine kinase inhibitors and mammalian target of Rapamycin inhibitors in patients with malignancies: A meta …
The energy sensor AMP-activated protein kinase (AMPK) signals neuronal death in glaucoma through inhibition of the mammalian target of Rapamycin (mTOR).
Comparison of the effect of bone marrow cells infusion through the portal vein and inferior vena cava combined with short‐term Rapamycin on allogeneic islet grafts in …
Effect of Rapamycin as an Inhibitor of the mTOR Cell Cycle Entry Complex on the Selective Lysis of Human Leukemia Cells Lines in Vitro Using 20 kHz Pulsed Low …
Expression of phosphorylated mammalian target of Rapamycin (p-mTOR) and phosphorylated eukaryotic translation initiation factor 4E binding protein 1 in pathologic …
Knock-in of Dnmt3a R878H Recapitulates Human Acute Myeloid Leukemia Harboring DNMT3A Mutation and Is Highly Responsive to mTOR Inhibitor Rapamycin
Prescriber treatment patterns for tyrosine kinase inhibitors (TKI) and mammalian target of Rapamycin (mTOR) inhibitors in patients with renal cell carcinoma.
TCT-456 Direct Implantation of Rapamycin-Eluting Stents with Bioresorbable Drug Carrier Technology Utilizing the Svelte Coronary Stent-on-a-Wire: 2-Year Follow …
Optimal dietary alphaâ linolenic acid/linoleic acid ratio improved digestive and absorptive capacities and target of Rapamycin gene expression of juvenile grass carp …
Rapamycin protects livers from ischemia and reperfusion Injury via both autophagy induction and mTORC2-Akt activation
Activation of mammalian target of Rapamycin complex 1 (mTORC1) and 2 (mTORC2) is required for retinal ganglion cell dendrite regeneration after axonal injury.
AB0061 mTOR inhibition by Rapamycin is Associated with Downregulation of Pro-Infammatory Cytokine TNFα, and Genes Involved in Bone Resoption (MMP-9 and …
… stretch promotes mesenchymal stem cell-osteoblast lineage migration through activation of mammalian target of Rapamycin/matrix metalloproteinases signaling …
… FOR PATIENTS WITH MULTIPLE VESSEL DISEASE AND UNPROTECTED LEFT MAIN WITH A COBALT-CHROMIUM Rapamycin ELUTING STENT: TWO YEARS …
… acid broadly suppresses cancer metabolism and synergistically induces strong anticancer activity in combination with Etoposide, Rapamycin and UCN-01
… Trial of Lymphocyte-Selective Pentostatin Plus Cyclophosphamide Conditioning, High Dose Sirolimus and Pre-Emptive DLI with Rapamycin-Resistant Donor CD4+ T …
Functional Proteomics Identifies Acinus L as a Direct Insulin-and Amino Acid-Dependent Mammalian Target of Rapamycin Complex 1 (mTORC1) Substrate* DS
Neuropeptides stimulate pro-inflammatory mediator secretion from human microglia through mammalian target of Rapamycin signaling, which is inhibited by the …
TCT-598 Revascularization strategies for patients with multiple vessel disease and unprotected left main with a cobalt-chromium Rapamycin eluting stent (ERACI IV …
REDOX SENSITIVE ACTIVATION OF MAMMALIAN TARGET OF Rapamycin SIGNALING COMPLEX-2 (mTORC2): ROLE OF SUPEROXIDE ANION IN ACTIVATION …
Lifespan extension in a semelparous chordate Oikopleura dioica via developmental growth arrest: Roles of Target of Rapamycin (TOR) signaling and D type cyclins
Rictor Oxidation and Disruption of the Mammalian Target of Rapamycin Complex 2 (mTORC2) Links Mitochondrial Oxidative Stress to Insulin Resistance in …
INSULINE LIKE GROWTH FACTOR-1 AND LEUCINE ACTIVATE PIG MYOGENIC SATELLITE CELLS THROUGH MAMMALIAN TARGET OF Rapamycin …
Phosphatidylinositol 3-kinase/protein kinase B/mammalian target of Rapamycin signaling pathway and epilepsy
… standard chemotherapy: Final results of a phase I study of infusional cyclophosphamide (cy), pulse dexamethasone (dex), Rapamycin (rapa) and hydroxychloroquine …
Combined Application of Phosphoinositide 3-Kinase and Mammalian Target of Rapamycin Inhibitors Suppresses Cell Growth and Promotes Apoptosis in …
Clinical significance of the expression of eukaryotic initiation factor 4 E and mammalian target of Rapamycin in esophageal squamous carcinoma tissues
MP39-11 DECREASING SURVIVIN BY YM155 REVERSES Rapamycin RESISTANCE IN RENAL CANCER
Targeted inhibition of phosphoinositide 3-kinase (PI3K)/mammalian target of Rapamycin (mTOR) sensitizes pancreatic cancer cells to doxorubicin without …
ID: 21: ALTERNATIVE Rapamycin TREATMENT REGIMENS MITIGATE THE IMPACT OF Rapamycin ON GLUCOSE HOMEOSTASIS AND THE IMMUNE SYSTEM …
MP39-06 ENHANCED CELL PROLIFERATION AND INCREASED RESISTANCE TO MAMMALIAN TARGET OF Rapamycin INHIBITORS BY inhibition OF 4E …
MP65-08 A PHARMACODYNAMIC PHASE 0/I STUDY OF ORAL Rapamycin IN PATIENTS UNDERGOING RADICAL CYSTECTOMY FOR BLADDER CANCER
… of milk protein synthesis by energy and essential amino acids through adenosine 5′-monophosphate-activated protein kinase/mammalian target Rapamycin …
… on apoptosis of HL-60 leukemic cells via the regulation of the phosphatidylinositol 3-kinase/serine/threonine protein kinase/mammalian target of Rapamycin signaling …
inhibition of Galectin-1 sensitizes oncogenic H-Ras to Rapamycin treatment
FCT 1-1 Oral sirolimus (Rapamycin) on 22 patients with various types of vascular anomalies
293. Optimal In Vivo Treg Induction and Suppression of Immune Responses By Synergistic Use of Rapamycin and FLT3 Ligand
Abstract LB-027: inhibition of mammalian target of Rapamycin by Torin2, an ATP-competitive inhibitor, induces growth inhibition in adult T cell leukemia
… of histidine on expressions of β-casein, and Janus kinases 2-signal transducer and activator of transcription 5/mammalian target Rapamycin signaling pathways related …
5-Azacytidine and Rapamycin: different and synergistic effect on ex vivo expansion of natural human T Regulatory cells
Different and synergistic effect of 5-Azacytidine and Rapamycin on ex vivo expansion of natural human T Regulatory cells
FCT-05: Topical Rapamycin: The promising therapeutic agent for lymphangioma circumscriptum
Kinome Screen Reveals SGK1 as a Therapeutic Target for NF2: inhibition of mTORC1/2 is More Effective than Rapamycin
P075 Prospective pilot study on combined use of pulsed dye laser and 1% topical Rapamycin of cutaneous capillary malformation
Abstract# 1853 Behaviorally conditioning of anti-proliferative and immosuppressive effects with Rapamycin
Abstract P622: Regulation of Neuroprotective Myeloid Cell Leukemia 1 by Rapamycin and AT2R Agonists in Dopaminergic Neuronal Cell-line
Breast Cancer Development in Rats Under the Influence of Platelet Factor-4 (PF4) And/or Rapamycin
EPT-13 RAPIRI I–PHASE I STUDY OF DAILY ORAL Rapamycin AND INTRAVENOUS IRINOTECAN IN CHILDREN WITH A RECURRENT/REFRACTORY …
An overview of Rapamycin: from discovery to future perspectives
A randomized controlled trial to establish effects of short-term Rapamycin treatment in 24 middle-aged companion dogs
Towards natural mimetics of metformin and Rapamycin
The role of mammalian target of Rapamycin (mTOR) in insulin signaling
Rapamycin in mice
Cryo-EM structure of Saccharomyces cerevisiae target of Rapamycin complex 2
The complex roles of mechanistic target of Rapamycin in adipocytes and beyond
Game of TOR—the target of Rapamycin rules four kingdoms
Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2‐independent mechanism
Rapamycin treatment attenuates age-associated periodontitis in mice
A functional mammalian target of Rapamycin complex 1 signaling is indispensable for c‐Myc‐driven hepatocarcinogenesis
Combination of Rapamycin and resveratrol for treatment of bladder cancer
Mammalian target of Rapamycin (mTOR) as a potential therapeutic target in various diseases
inhibition of mammalian target of Rapamycin signaling with Rapamycin prevents trauma-induced heterotopic ossification
Short‐term Rapamycin treatment increases ovarian lifespan in young and middle‐aged female mice
Low-dose Rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome
Reperfusion therapy with Rapamycin attenuates myocardial infarction through activation of AKT and ERK
Anti-HER2 immunoliposomes for co-delivery of paclitaxel and Rapamycin for breast cancer therapy
Target of Rapamycin (TOR) regulates growth in response to nutritional signals
Epigenetic aging signatures in mice livers are slowed by dwarfism, calorie restriction and Rapamycin treatment
Rapamycin suppresses microglial activation and reduces the development of neuropathic pain after spinal cord injury
Emerging role for mammalian target of Rapamycin in male fertility
Anti‐aging pharmacology in cutaneous wound healing: effects of metformin, resveratrol, and Rapamycin by local application
Rapamycin is highly effective in murine models of immune-mediated bone marrow failure
Rapamycin reversal of VEGF-C–driven lymphatic anomalies in the respiratory tract
Rapamycin and the inhibition of the secretory phenotype
Rapamycin-mediated mTOR inhibition uncouples HIV-1 latency reversal from cytokine-associated toxicity
Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer’s disease
Mechanistic target of Rapamycin is necessary for changes in dendritic spine morphology associated with long-term potentiation
The crosstalk between Target of Rapamycin (TOR) and Jasmonic Acid (JA) signaling existing in Arabidopsis and cotton
Dietary Rapamycin supplementation reverses age‐related vascular dysfunction and oxidative stress, while modulating nutrient‐sensing, cell cycle, and senescence …
Resistance exercise initiates mechanistic target of Rapamycin (mTOR) translocation and protein complex co-localisation in human skeletal muscle
Ectopic expression of Arabidopsis Target of Rapamycin (AtTOR) improves water-use efficiency and yield potential in rice
Microcystic lymphatic malformation successfully treated with topical Rapamycin
Rapamycin upregulates glutamate transporter and IL-6 expression in astrocytes in a mouse model of Parkinson’s disease
Rapamycin effectively impedes melamine-induced impairments of cognition and synaptic plasticity in Wistar rats
Rapamycin protects sepsis-induced cognitive impairment in mouse hippocampus by enhancing autophagy
Rapamycin inhibits spermatogenesis by changing the autophagy status through suppressing mechanistic target of Rapamycin-p70S6 kinase in male rats
Rapamycin eye drops suppress lacrimal gland inflammation in a murine model of Sjögren’s syndrome
Mammalian target of Rapamycin complex 2 regulates muscle glucose uptake during exercise in mice
Evolution of disease activity and biomarkers on and off Rapamycin in 28 patients with autoimmune lymphoproliferative syndrome
Rapamycin prevents cyclophosphamide-induced over-activation of primordial follicle pool through PI3K/Akt/mTOR signaling pathway in vivo
Mammalian target of Rapamycin (mTOR) as a potential therapeutic target in pathological ocular angiogenesis
Rapamycin regulates macrophage activation by inhibiting NLRP3 inflammasome-p38 MAPK-NFκB pathways in autophagy-and p62-dependent manners
GTP ase ROP 2 binds and promotes activation of target of Rapamycin, TOR, in response to auxin
Infantile Lhermitte-Duclos disease treated successfully with Rapamycin
Rapamycin suppresses Aβ25–35-or LPS-induced neuronal inflammation via modulation of NF-κB signaling
Post onset, oral Rapamycin treatment delays development of mitochondrial encephalopathy only at supramaximal doses
Mammalian target of Rapamycin (mTOR): a central regulator of male fertility?
The triangle of death in Alzheimer’s disease brain: the aberrant cross-talk among energy metabolism, mammalian target of Rapamycin signaling, and protein …
Differential regulation of cardiac function and intracardiac cytokines by Rapamycin in healthy and diabetic rats
Rapamycin ameliorates experimental autoimmune encephalomyelitis by suppressing the mTOR-STAT3 pathway
Brassinosteriod Insensitive 2 (BIN2) acts as a downstream effector of the Target of Rapamycin (TOR) signaling pathway to regulate photoautotrophic growth in …
Rapamycin prolongs the survival of corneal epithelial cells in culture
Blocking mTOR signalling with Rapamycin ameliorates imiquimod-induced psoriasis in mice
Rapamycin adjuvant and exacerbation of severe influenza in an experimental mouse model
Efficacy of topical sirolimus (Rapamycin) for the treatment of microcystic lymphatic malformations
Rapamycin inhibits oxidative/nitrosative stress and enhances angiogenesis in high glucose-treated human umbilical vein endothelial cells: role of autophagy
Progressive slowdown/prevention of cellular senescence by CD9-targeted delivery of Rapamycin using lactose-wrapped calcium carbonate nanoparticles
Rapamycin treatment dose‐dependently improves the cystic kidney in a new ADPKD mouse model via the mTORC1 and cell‐cycle‐associated CDK1/cyclin axis
Fluoride-induced autophagy via the regulation of phosphorylation of mammalian targets of Rapamycin in mice leydig cells
Modulation of nonsense mediated decay by Rapamycin
Targeted co-delivery of polypyrrole and Rapamycin by trastuzumab-conjugated liposomes for combined chemo-photothermal therapy
mTORC1 inhibition with Rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function
OP16, a novel ent-kaurene diterpenoid, potentiates the antitumor effect of Rapamycin by inhibiting Rapamycin-induced feedback activation of Akt signaling in …
Mechanistic target of Rapamycin is a novel molecular mechanism linking folate availability and cell function
Rapamycin confers neuroprotection against colistin-induced oxidative stress, mitochondria dysfunction, and apoptosis through the activation of autophagy and mTOR …
Neuroprotection through Rapamycin-induced activation of autophagy and PI3K/Akt1/mTOR/CREB signaling against amyloid-β-induced oxidative stress, synaptic …
Rapamycin protects against paraquat-induced pulmonary fibrosis: Activation of Nrf2 signaling pathway
Cell-autonomous requirement for mammalian target of Rapamycin (mTOR) in spermatogonial proliferation and differentiation in the mouse
Mammalian target of Rapamycin inhibition counterbalances the inflammatory status of immune cells in patients with chronic granulomatous disease
inhibition of mammalian target of Rapamycin (mTOR) signaling in the insular cortex alleviates neuropathic pain after peripheral nerve injury
Antifibrotic effect of Rapamycin containing polyethylene glycol‐coated alginate microcapsule in islet xenotransplantation
Rapamycin-induced miR-21 promotes mitochondrial homeostasis and adaptation in mTORC1 activated cells
Rapamycin nanoparticles localize in diseased lung vasculature and prevent pulmonary arterial hypertension
The post‐therapeutic effect of Rapamycin in mild traumatic brain‐injured rats ensuing in the upregulation of autophagy and mitophagy
Mammalian target of Rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death
In vitro and in vivo degradation of Rapamycin-eluting Mg-Nd-Zn-Zr alloy stents in porcine coronary arteries
Rapamycin maintains the chondrocytic phenotype and interferes with inflammatory cytokine induced processes
Bifunctional elastin-like polypeptide nanoparticles bind Rapamycin and integrins and suppress tumor growth in Vivo
Role for target of Rapamycin (mTOR) signal pathway in regulating neuronal injury after intracerebral hemorrhage
Inactivation of regulatory-associated protein of mTOR (Raptor)/mammalian target of Rapamycin complex 1 (mTORC1) signaling in osteoclasts increases bone …
m TOR inhibition by Rapamycin protects against deltamethrin‐induced apoptosis in PC 12 Cells
Rapamycin-insensitive companion of mTOR (RICTOR) amplification defines a subset of advanced gastric cancer and is sensitive to AZD2014-mediated …
Rapamycin augments immunomodulatory properties of bone marrow-derived mesenchymal stem cells in experimental autoimmune encephalomyelitis
Effects of ketamine administration on mTOR and reticulum stress signaling pathways in the brain after the infusion of Rapamycin into prefrontal cortex
Placentome nutrient transporters and mammalian target of Rapamycin signaling proteins are altered by the methionine supply during late gestation in dairy cows and …
The molecular mechanism of glucagon-like peptide-1 therapy in Alzheimer’s disease, based on a mechanistic target of Rapamycin pathway
Synergistic effect of Rapamycin and metformin against age-dependent oxidative stress in rat erythrocytes
Thioredoxin-1 maintains mechanistic target of Rapamycin (mTOR) function during oxidative stress in cardiomyocytes
Rapamycin sensitizes cancer cells to growth inhibition by the PARP inhibitor olaparib
Rapamycin facilitates fracture healing through inducing cell autophagy and suppressing cell apoptosis in bone tissues
Single and combined effect of retinoic acid and Rapamycin modulate the generation, activity and homing potential of induced human regulatory T cells
Hyaluronic acid nanohydrogel loaded with quercetin alone or in combination to a macrolide derivative of Rapamycin RAD001 (Everolimus) as a new treatment for …
Combination of Rapamycin and garlic-derived S-allylmercaptocysteine induces colon cancer cell apoptosis and suppresses tumor growth in xenograft nude …
Rapamycin attenuates acute seizure-induced astrocyte injury in mice in vivo
Rapamycin-induced autophagy restricts porcine epidemic diarrhea virus infectivity in porcine intestinal epithelial cells
inhibition of Cyclosporine A or Rapamycin on T lymphocyte counts and the influence on the immune responses of B lymphocytes in flounder (Paralichthys olivaceus)
… acid transporter SLC 36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of Rapamycin, complex 1 signaling
Pre-S2 mutant-induced mammalian target of Rapamycin signal pathways as potential therapeutic targets for hepatitis B virus-associated hepatocellular carcinoma
Increased expression of (immuno) proteasome subunits during epileptogenesis is attenuated by inhibition of the mammalian target of Rapamycin pathway
Rapamycin modulated brain-derived neurotrophic factor and B-cell lymphoma 2 to mitigate autism spectrum disorder in rats
inhibition of mammalian target of Rapamycin complex 1 attenuates salt-induced hypertension and kidney injury in dahl salt-sensitive rats
Everolimus is better than Rapamycin in attenuating neuroinflammation in kainic acid-induced seizures
Cryptotanshinone inhibition of mammalian target of Rapamycin pathway is dependent on oestrogen receptor alpha in breast cancer
Adrenoceptors promote glucose uptake into adipocytes and muscle by an insulin-independent signaling pathway involving mechanistic target of Rapamycin complex 2
Combination therapy for inhibitor reversal in haemophilia A using monoclonal anti-CD20 and Rapamycin
Berunda polypeptides: multi-headed fusion proteins promote subcutaneous administration of Rapamycin to breast cancer in vivo
Two mTOR inhibitors, Rapamycin and Torin 1, differentially regulate iron-induced generation of mitochondrial ROS
Combined targeting of mTOR and Akt using Rapamycin and MK-2206 in the treatment of tuberous sclerosis complex
Rapamycin and CHIR 99021 Coordinate Robust Cardiomyocyte Differentiation From Human Pluripotent Stem Cells Via Reducing p53‐Dependent Apoptosis
Choline kinase α mediates interactions between the epidermal growth factor receptor and mechanistic target of Rapamycin complex 2 in hepatocellular carcinoma cells …
Usnic acid benzylidene analogues as potent mechanistic target of Rapamycin inhibitors for the control of breast malignancies
PEGylated lipid bilayer-wrapped nano-graphene oxides for synergistic co-delivery of doxorubicin and Rapamycin to prevent drug resistance in cancers
A brain proteomic investigation of Rapamycin effects in the Tsc1+/− mouse model
Rapamycin promotes the survival and adipogenesis of ischemia-challenged adipose derived stem cells by improving autophagy
Rapamycin inhibits mTOR/p70S6K activation in CA3 region of the hippocampus of the rat and impairs long term memory
Chronic treatment with novel nanoformulated micelles of Rapamycin, Rapatar, protects diabetic heart against ischaemia/reperfusion injury
… seizures and associated neurological conditions in lithium-pilocarpine rat model of temporal lobe epilepsy through inhibition of mammalian target of Rapamycin …
Inhibiting PLK1 induces autophagy of acute myeloid leukemia cells via mammalian target of Rapamycin pathway dephosphorylation
… carcinoma recurrence after living donor liver transplantation for patients within the UCSF criteria: re-inventing the role of mammalian target of Rapamycin …
Optimal ratios of essential amino acids stimulate β-casein synthesis via activation of the mammalian target of Rapamycin signaling pathway in MAC-T cells and …
mTOR (mechanistic target of Rapamycin) inhibition decreases mechanosignaling, collagen accumulation, and stiffening of the thoracic aorta in elastin-deficient mice
Brain injury-induced synaptic reorganization in hilar inhibitory neurons is differentially suppressed by Rapamycin
Rapamycin-loaded immunoliposomes functionalized with Trastuzumab: a strategy to enhance cytotoxicity to HER2-positive breast cancer cells
Loss of cardiac carnitine palmitoyltransferase 2 results in Rapamycin-resistant, acetylation-independent hypertrophy
inhibition of 4EBP phosphorylation mediates the cytotoxic effect of mechanistic target of Rapamycin kinase inhibitors in aggressive B-cell lymphomas
Prognostic significance and function of mammalian target of Rapamycin in tongue squamous cell carcinoma
Rictor/mammalian target of Rapamycin complex 2 promotes macrophage activation and kidney fibrosis
A pilot study on using Rapamycin-carrying synthetic vaccine particles (SVP) in conjunction with enzyme replacement therapy to induce immune tolerance in …
Kinetic modeling and analysis of the akt/mechanistic target of Rapamycin complex 1 (mTORC1) signaling axis reveals cooperative, feedforward regulation
Neuroprotective effects of intrastriatal injection of Rapamycin in a mouse model of excitotoxicity induced by quinolinic acid
inhibition of p70S6K does not mimic the enhancement of Akt phosphorylation by Rapamycin
Modulation of the immune response in rheumatoid arthritis with strategically released Rapamycin
Target of Rapamycin signaling mediates vacuolar fragmentation
Chronic exposure to Rapamycin and episodic serum starvation modulate ageing of human fibroblasts in vitro
Topical Rapamycin for facial angiofibromas in a child with tuberous sclerosis complex (TSC): a case report and long-term follow-up
Mammalian target of Rapamycin (mTOR) regulates transforming growth factor-β1 (TGF-β1)-induced epithelial-mesenchymal transition via decreased pyruvate …
Rapamycin decreased blood-brain barrier permeability in control but not in diabetic rats in early cerebral ischemia
Enhancement of Rapamycin production by metabolic engineering in Streptomyces hygroscopicus based on genome-scale metabolic model
Celastrol prevents cadmium‐induced neuronal cell death by blocking reactive oxygen species‐mediated mammalian target of Rapamycin pathway
Identification of mechanically regulated phosphorylation sites on tuberin (TSC2) that control mechanistic target of Rapamycin (mTOR) signaling
… , dedifferentiation, and Rapamycin resistance of vascular smooth muscle cells by inhibiting insulin-like growth factor-1 receptor and mammalian target of Rapamycin
Antitumor Synergism and Enhanced Survival with a Tumor Vasculature–Targeted Enzyme Prodrug System, Rapamycin, and Cyclophosphamide
Rapamycin inhibits the proliferation of endothelial cells in hemangioma by blocking the mTOR-FABP4 pathway
The downregulation of ATG4B mediated by microRNA-34a/34c-5p suppresses Rapamycin-induced autophagy
The effect of Rapamycin, NVP-BEZ235, aspirin, and metformin on PI3K/AKT/mTOR signaling pathway of PIK3CA-related overgrowth spectrum (PROS)
Treatment of port wine stains using pulsed dye laser, erbium YAG laser, and topical Rapamycin (sirolimus)—A randomized controlled trial
Rapamycin modulation of p70 S6 kinase signaling inhibits Rift Valley fever virus pathogenesis
Improvement in renal cystic disease of tuberous sclerosis complex after treatment with mammalian target of Rapamycin inhibitor
Rapamycin promotes differentiation increasing βIII-tubulin, NeuN, and NeuroD while suppressing nestin expression in glioblastoma cells
Tanshinone IIA affects autophagy and apoptosis of glioma cells by inhibiting phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin signaling pathway
Antidepressant actions of ketamine mediated by the mechanistic target of Rapamycin, nitric oxide, and Rheb
Mesangial cell mammalian target of Rapamycin complex 1 activation results in mesangial expansion
Preservation of anticancer and immunosuppressive properties of Rapamycin achieved through controlled releasing particles
Improved antitumor effect of ionizing radiation in combination with Rapamycin for treating nasopharyngeal carcinoma
Combination of IL-2, Rapamycin, DNA methyltransferase and histone deacetylase inhibitors for the expansion of human regulatory T cells
A mechanistic target of Rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin …
… eukaryotic initiation factor 3C (EIF3C) suppresses proliferation and stimulates apoptosis in breast cancer cell lines through mammalian target of Rapamycin …
The mammalian target of Rapamycin and DNA methyltransferase 1 axis mediates vascular endothelial dysfunction in response to disturbed flow
Approaches towards the enhanced production of Rapamycin by Streptomyces hygroscopicus MTCC 4003 through mutagenesis and optimization of process …
Triggering of eryptosis, the suicidal erythrocyte death by mammalian target of Rapamycin (mTOR) inhibitor temsirolimus
CD9 monoclonal antibody-conjugated PEGylated liposomes for targeted delivery of Rapamycin in the treatment of cellular senescence
Rapamycin promotes osteogenesis under inflammatory conditions
Programmed cell death‐1 (PD‐1) checkpoint blockade in combination with a mammalian target of Rapamycin inhibitor restrains hepatocellular carcinoma growth …
Suppression of Th17-polarized airway inflammation by Rapamycin
Impact on autophagy and ultraviolet B induced responses of treatment with the mTOR inhibitors Rapamycin, Everolimus, Torin 1, and pp242 in human …
Overgrowth syndromes caused by somatic variants in the phosphatidylinositol 3-kinase/AKT/mammalian target of Rapamycin pathway
Ketamine exhibits different neuroanatomical profile after mammalian target of Rapamycin inhibition in the prefrontal cortex: the role of inflammation and oxidative stress
Chemokine (CC motif) ligand 18 upregulates Slug expression to promote stem‐cell like features by activating the mammalian target of Rapamycin pathway in oral …
Rapamycin/sodium hyaluronate binding on nano-hydroxyapatite coated titanium surface improves MC3T3-E1 osteogenesis
Biphasic Rapamycin effects in lymphoma and carcinoma treatment
CENPH inhibits Rapamycin sensitivity by regulating GOLPH3-dependent mTOR signaling pathway in colorectal cancer
Reciprocal regulation of target of Rapamycin complex 1 and potassium accumulation
Rapamycin-loaded nanoporous α-Fe 2 O 3 as an endothelial favorable and thromboresistant coating for biodegradable drug-eluting Fe stent applications
Programmed Death-1 inhibition of Phosphatidylinositol 3-Kinase/AKT/Mechanistic Target of Rapamycin Signaling Impairs Sarcoidosis CD4+ T Cell Proliferation
Rapamycin enhances repressed autophagy and attenuates aggressive progression in a rat model of IgA nephropathy
Intrauterine growth retardation promotes fetal intestinal autophagy in rats via the mechanistic target of Rapamycin pathway
Construction of a Rapamycin-susceptible strain of the unicellular red alga Cyanidioschyzon merolae for analysis of the target of Rapamycin (TOR) function
While reinforcing cell cycle arrest, Rapamycin and Torins suppress senescence in UVA-irradiated fibroblasts
Expression of (pro) renin receptor during Rapamycin-induced erythropoiesis in K562 erythroleukemia cells and its possible dual actions on erythropoiesis
Isoimperatorin ameliorates osteoarthritis by downregulating the mammalian target of Rapamycin C1 signaling pathway
Folic acid orchestrates root development linking cell elongation with auxin response and acts independently of the TARGET OF Rapamycin signaling in Arabidopsis …
inhibition of mTOR pathway by Rapamycin decreases P-glycoprotein expression and spontaneous seizures in pharmacoresistant epilepsy
Mammalian target of Rapamycin signaling is a mechanistic link between increased endoplasmic reticulum stress and autophagy in the placentas of pregnancies …
Discovery of simplified leucyladenylate sulfamates as novel leucyl-tRNA synthetase (LRS)-targeted mammalian target of Rapamycin complex 1 (mTORC1) inhibitors
General control nonderepressible 2 (GCN2) kinase inhibits target of Rapamycin complex 1 in response to amino acid starvation in Saccharomyces cerevisiae
Renal function in heart transplant patients after switch to combined mammalian target of Rapamycin inhibitor and calcineurin inhibitor therapy
Delayed and short course of Rapamycin prevents organ rejection after allogeneic liver transplantation in rats
Rapamycin and bafilomycin A1 alter autophagy and megakaryopoiesis
… protein 1 activity by way of the calcium/calmodulin‐dependent kinase kinase–AMP‐activated protein kinase–mechanistic target of Rapamycin–p70 ribosomal S6 …
Covalent modification of pericardial patches for sustained Rapamycin delivery inhibits venous neointimal hyperplasia
Dynamin-dependent amino acid endocytosis activates mechanistic target of Rapamycin complex 1 (mTORC1)
Naringin in Ganshuang Granule suppresses activation of hepatic stellate cells for anti‐fibrosis effect by inhibition of mammalian target of Rapamycin
Rapamycin protects testes against germ cell apoptosis and oxidative stress induced by testicular ischemia-reperfusion
miR-338-3p confers 5-fluorouracil resistance in p53 mutant colon cancer cells by targeting the mammalian target of Rapamycin
Combination of histidine, lysine, methionine, and leucine promotes β-casein synthesis via the mechanistic target of Rapamycin signaling pathway in bovine …
Temporal changes in mammalian target of Rapamycin (mTOR) and phosphorylated-mTOR expressions in the hippocampal CA1 region of rat with vascular …
Rapamycin treatment for benign multicystic peritoneal mesothelioma: a rare disease with a difficult management
Rapamycin preferentially inhibits human IL-5+ TH2-cell proliferation via an mTORC1/S6 kinase-1–dependent pathway
Effect of Rapamycin treatment during post‐activation and/or in vitro culture on embryonic development after parthenogenesis and in vitro fertilization in pigs
Glucose adsorption to chitosan membranes increases proliferation of human chondrocyte via mammalian target of Rapamycin complex 1 and sterol regulatory element …
Use of Rapamycin in a patient with juvenile myelomonocytic leukemia: a case report
Role of mammalian target of Rapamycin signaling in autophagy and the neurodegenerative process using a senescence accelerated mouse‑prone 8 model
Effects of cyclosporine, tacrolimus, and Rapamycin on osteoblasts
Neonatal mouse hippocampus: phlebotomy-induced anemia diminishes and treatment with erythropoietin partially rescues mammalian target of Rapamycin …
Activation of the unfolded protein response in sarcoma cells treated with Rapamycin or temsirolimus
Prenatal mechanistic target of Rapamycin complex 1 (m TORC1) inhibition by Rapamycin treatment of pregnant mice causes intrauterine growth restriction and alters …
Progeroid syndrome patients with ZMPSTE24 deficiency could benefit when treated with Rapamycin and dimethylsulfoxide
Therapeutic effects of Rapamycin on alcoholic cardiomyopathy
Lycorine induces apoptosis of A549 cells via AMPK-mammalian target of Rapamycin (mTOR)-S6K signaling pathway
… cells from reactive oxygen species through changes in autophagy and activation of phosphatidylinositol 3-kinase, protein kinas B, and mechanistic target of Rapamycin …
… through CC Motif Chemokine Receptor 2–Dependent Phosphatidylinositol 3-Kinase-AKT–Mechanistic Target of Rapamycin Signaling and Hypoxia-Inducible …
Autophagy activation by Rapamycin before hypoxia-reoxygenation reduces endoplasmic reticulum stress in alveolar epithelial cells
Determination of mammalian target of Rapamycin hyperactivation as prognostic factor in well-differentiated neuroendocrine tumors
Rapamycin alleviates inflammation and muscle weakness, while altering the Treg/Th17 balance in a rat model of myasthenia gravis
Rapamycin efficiently promotes cardiac differentiation of mouse embryonic stem cells
mTORC1 inhibitors Rapamycin and metformin affect cardiovascular markers differentially in ZDF rats
Rapamycin reduced pulmonary vascular remodelling by inhibiting cell proliferation via Akt/mTOR signalling pathway down-regulation in the carotid artery–jugular vein …
Rapamycin induces autophagy and reduces the apoptosis of podocytes under a stimulated condition of immunoglobulin a nephropathy
inhibition of hemangioma growth using polymer–lipid hybrid nanoparticles for delivery of Rapamycin
Phosphorylated Mechanistic target of Rapamycin (p-mTOR) and Noncoding RNA expression in follicular and Hürthle cell thyroid neoplasm
Rapamycin suppresses hypoxia/reoxygenation‐induced islet injury by up‐regulation of miR‐21 via PI3K/Akt signalling pathway
Evaluating the effectiveness of GTM-1, Rapamycin, and carbamazepine on autophagy and Alzheimer disease
Probing the phosphatidylinositol 3‐kinase/mammalian target of Rapamycin pathway in gliomas: A phase 2 study of everolimus for recurrent adult low‐grade gliomas
IFN-γ orchestrates mesenchymal stem cell plasticity through the signal transducer and activator of transcription 1 and 3 and mammalian target of Rapamycin pathways
Rapamycin (mTORC1 inhibitor) reduces the production of lactate and 2-hydroxyglutarate oncometabolites in IDH1 mutant fibrosarcoma cells
Mammalian target of Rapamycin signaling and ubiquitin proteasome–related gene expression in 3 different skeletal muscles of colostrum-versus formula-fed …
… mediates the effect of micro RNA‐26a on cell growth, migration, and invasion in hepatocellular carcinoma through the protein kinase B/mammalian target of Rapamycin …
Short-course Rapamycin treatment enables engraftment of immunogenic gene-engineered bone marrow under low-dose irradiation to permit long-term …
Meta-analysis of 29 experiments evaluating the effects of Rapamycin on life span in the laboratory mouse
Hyperactivation of mammalian target of Rapamycin complex 1 by HIV‐1 is necessary for virion production and latent viral reactivation
Migratory properties of ex vivo expanded regulatory T cells: influence of all-trans retinoic acid and Rapamycin
Differential role of Rapamycin in epidermis-induced IL-15-IGF-1 secretion via activation of Akt/mTORC2
Target of Rapamycin complex 1 and Tap42‐associated phosphatases are required for sensing changes in nitrogen conditions in the yeast Saccharomyces cerevisiae
Co‐Delivery of Disease Associated Peptide and Rapamycin via Acetalated Dextran Microparticles for Treatment of Multiple Sclerosis
A single Rapamycin dose protects against late-stage experimental cerebral malaria via modulation of host immunity, endothelial activation and parasite …
Attenuation of pentylenetrazole-induced acute status epilepticus in rats by adenosine involves inhibition of the mammalian target of Rapamycin pathway
A new treatment for vascular anomalies: Six cases treated with Rapamycin
Systemic meta-analysis assessing the short term applicability of early conversion to mammalian target of Rapamycin inhibitors in kidney transplant
Association between high expression of phosphorylated Akt and mammalian target of Rapamycin and improved survival in salivary gland adenoid cystic carcinoma
Mycophenolate mofetil and Rapamycin induce apoptosis in the human monocytic U937 cell line through two different pathways
Rapamycin enhances the anti-angiogenesis and anti-proliferation ability of YM155 in oral squamous cell carcinoma
2,5-Dimethyl-Celecoxib Extends Drosophila Life Span via a Mechanism That Requires Insulin and Target of Rapamycin Signaling
Rapamycin targets several pathophysiological features of immune-mediated bone marrow failure in murine models
Rapid Rapamycin-only induced osteogenic differentiation of blood-derived stem cells and their adhesion to natural and artificial scaffolds
Biodegradable cable-tie Rapamycin-eluting stents
Use of sirolimus (Rapamycin) for treatment of cytopenias and lymphoproliferation linked to autoimmune lymphoproliferative syndrome (ALPS). Two case reports
Triolimus: A multi‐drug loaded polymeric micelle containing paclitaxel, 17‐AAG, and Rapamycin as a novel radiosensitizer
Immunosuppression With CD 40 Costimulatory Blockade Plus Rapamycin for Simultaneous Islet–Kidney Transplantation in Nonhuman Primates
Role of triggering receptor expressed on myeloid cell-1 expression in mammalian target of Rapamycin modulation of CD8+ T-cell differentiation during the …
Expression of miRNA-155 in carotid atherosclerotic plaques of apolipoprotein E knockout (ApoE−/−) mice and the interventional effect of Rapamycin
Beneficial effects of Rapamycin in a Drosophila model for hereditary spastic paraplegia
Mammalian target of Rapamycin complex 1 signalling is essential for germinal centre reaction
MicroRNA-185-5p restores glucocorticoid sensitivity by suppressing the mammalian target of Rapamycin complex (mTORC) signaling pathway to enhance …
Rapamycin inhibits expansion of cord blood derived NK and T cell
Rapamycin induces human acute promyelocytic leukemia cell HL-60 autophagic apoptosis
Mammalian target of Rapamycin inhibitors, temsirolimus and torin 1, attenuate stemness-associated properties and expression of mesenchymal markers promoted by …
Rapamycin inhibits CaCl2-induced thoracic aortic aneurysm formation in rats through mTOR-mediated suppression of proinflammatory mediators
Rapamycin-ameliorated diabetic symptoms involved in increasing adiponectin expression in diabetic mice on a high-fat diet
Rapamycin-sensitive late-LTP is enhanced in the hippocampus of IL-6 transgenic mice
Effects of the mammalian target of Rapamycin inhibitor everolimus on hepatitis C virus replication in vitro and in vivo
Conversion to mammalian target of Rapamycin inhibitors in kidney transplant recipients with de novo cancers
The antimalarial action of FK506 and Rapamycin: evidence for a direct effect on FK506-binding protein PfFKBP35
Down regulation of Peroxiredoxin-3 in 3T3-L1 adipocytes leads to oxidation of Rictor in the mammalian-target of Rapamycin complex 2 (mTORC2)
Rapamycin keeps the reproductive clock ticking
Prospective pilot study on combined use of pulsed dye laser and 1% topical Rapamycin for treatment of nonfacial cutaneous capillary malformation
Whey protein concentrate renders MDA-MB-231 cells sensitive to Rapamycin by altering cellular redox state and activating GSK3β/mTOR signaling
Insights into the metabolic mechanism of Rapamycin overproduction in the shikimate-resistant Streptomyces hygroscopicus strain UV-II using comparative …
Mammalian target of Rapamycin (mTOR)/nitric oxide system possibly modulate antidepressant-like effect of 17α-ethinyl estradiol in ovariectomized mice
Targeting glutamine metabolism and the focal adhesion kinase additively inhibits the mammalian target of the Rapamycin pathway in spheroid cancer stem …
An insight of Rapamycin against cadmium’s neurotoxicity
Mechanistic target of Rapamycin (mTOR): A mediator of social development
Prognostic Significance of periostin and mammalian target of Rapamycin (mTOR) in locally advanced esophageal squamous cell carcinoma
Rapamycin additively extends lifespan in short-and long-lived lines of the nematode Caenorhabditis remanei
Chronic Rapamycin treatment improved metabolic phenotype but inhibited adipose tissue browning in high-fat diet-fed C57BL/6J mice
Effects of mTOR Inhibitor Rapamycin on Burkitt’s Lymphoma Cells
Metabolic impact of Rapamycin (sirolimus) and B-estradiol using mouse embryonic fibroblasts as a model for lymphangioleiomyomatosis
Effects of Rapamycin on life span and on expression of TOR and S6K in Brachionus calyciflorus (Rotifera)
Mammalian target of Rapamycin complex 1 and FoxO1 in the transcriptional control of lipolysis and de novo lipogenesis
Nudix-type motif 2 contributes to cancer proliferation through the regulation of Rag GTPase-mediated mammalian target of Rapamycin complex 1 localization
De Novo Donor-Specific Antibody Formation in Tacrolimus-Based, Mycophenolate Versus Mammalian Target of Rapamycin Immunosuppressive Regimens.
PPAR gamma coactivator 1 beta (PGC-1β) reduces mammalian target of Rapamycin (mTOR) expression via a SIRT1-dependent mechanism in neurons
Effects of Rapamycin on clinical manifestations and blood lipid parameters in different preeclampsia-like mouse models
IL-21 augments Rapamycin in expansion of alpha fetoprotein antigen specific stem-cell-like memory t cells in vitro
The relationship between preptin, Forkhead box protein O1 and mechanistic target of Rapamycin levels in prediabetic patients.
Assessment of Response of Kidney Tumors to Rapamycin and Atorvastatin in Tsc1+/− Mice
Comparison of tyrosine kinase inhibitor versus mammalian target of Rapamycin inhibitor as second-line molecular-targeted therapy for patients with poor-risk …
Mammalian target of Rapamycin/eukaryotic initiation factor 4F pathway regulates follicle growth and development of theca cells in mice
Invariant natural killer T cells treated with Rapamycin or transforming growth factor-β acquire a regulatory function and suppress T effector lymphocytes
Pharmacologic characterization of SHR8443, a novel dual inhibitor of phosphatidylinositol 3-kinase and mammalian target of Rapamycin
Topical Rapamycin for facial angiofibromas in tuberous sclerosis complex
Moderate mammalian target of Rapamycin inhibition induces autophagy in HTR8/SVneo cells via O‐linked β‐N‐acetylglucosamine signaling
Fluorine-18-FDG PET/CT in a patient with angiomyolipoma: Response to mammalian target of Rapamycin inhibitor therapy
The influence of Rapamycin on the early cardioprotective effect of hypoxic preconditioning on cardiomyocytes
THU0245 Mammalian target of Rapamycin pathway might contribute the minor salivary gland changes in both sjogren’s syndrome and systemic sclerosis patients
Targeted dendritic cell therapy utilising antibody-displaying porous silicon nanoparticles loaded with Rapamycin
THU0176 Efficiency and safety of Rapamycin combined with low-dose IL-2 treatment compared with methotrexate in patients with rheumatoid arthritis
Kinetic modelling of in vitro data of PI3K, mTOR1, PTEN enzymes and on-target inhibitors Rapamycin, BEZ235, and LY294002
Nutrient medium optimization for Streptomyces hygroscopicus, a producer of Rapamycin pharmaceutical substance
Autophagy plays an important role in Rapamycin-mediated primary cultured neonatal rat cardiac myocytes death
Rapamycin therapy for neonatal tuberous sclerosis complex with cardiac rhabdomyomas: A case report and review
Extraction of Rapamycin (sirolimus) from Streptomyces Rapamycinicus using ultrasound
Effects of small rna interference targeting mammalian target of Rapamycin on paraquat-induced pulmonary fibrosis in rats
Rapamycin enhances the antiproliferative effect of transforming growth factor‑β on MCF‑7 human breast cancer cells
… domain 2-mediated signaling pathway in human dendritic cells in an X-linked inhibitor of apoptosis protein and mammalian target of Rapamycin-dependent …
Extending Lifespan by Inhibiting the Mechanistic Target of Rapamycin (mTOR)
Expression profile of mammalian target of Rapamycin‐related proteins in graft biopsy specimens: Significance for predicting interstitial fibrosis after kidney …
Surendra Nath Sehgal: A pioneer in Rapamycin discovery
Rapamycin attenuates atrial fibrosis in 5/6 nephrectomized rats by inhibiting mammalian target of Rapamycin and profibrotic signaling
Nitrogen starvation and Rapamycin both induce autophagic degradation of proteasome complexes
BRAF gene alterations and enhanced mammalian target of Rapamycin signaling in gangliogliomas
Monitoring Rapamycin treatment response in lymphangioleiomyomatosis with [18F] fluoroethylcholine PET
Corrigendum: Ectopic expression of Arabidopsis Target of Rapamycin (AtTOR) improves water-use efficiency and yield potential in rice
Historical story on natural medicinal chemistry: Rapamycin
Effect of immobilisation on production of Rapamycin by Streptomyces hygroscopicus
Themes: Title: Investigating Protein Binding Intractions of Rapamycin: pH variations
Effect of Rapamycin on early stage apoptosis of neutrophils in Sprague‑Dawley rats with acute lung injury
Tyrosine Kinase and Mammalian Target of Rapamycin Inhibitors in the Treatment of Advanced Renal Cell Carcinoma: Practical Clinical Implications of Pharmacologic …
Profile of Michael N. Hall, 2017 Albert Lasker Basic Medical Research Awardee: Target of Rapamycin, cell growth, and translational control
Lipid Sensing by Mammalian Target of Rapamycin
The Pharmacodynamic Functions of Low-Dose Rapamycin as a Model for Universal Influenza Protection
PERAN MAMMALIAN TARGET OF Rapamycin DALAM EPILEPSI
The efficacy of Rapamycin against the neuropathic pain for Fabry disease
Preoperative application of combination of portal venous injection of donor spleen cells and intraperitoneal injection of Rapamycin prolongs the survival of …
Anti-angiogenic effect of Rapamycin in mouse oxygen-induced retinopathy is mediated through suppression of HIF-1alpha/VEGF pathway
Effects of Rapamycin on blood lipid metabolism in renal transplant recipients
Short-term use of Rapamycin combined with Tregs prolongs mouse cardiac graft survival but attenuates recipient’s anti-tumor immunity
Allogeneic Hair Transplantation with Enhanced Survival by Anti-ICAM-1 Antibody with Short-Term Rapamycin Treatment in Nonhuman Primates
Important role for the mammalian‐target‐of‐Rapamycin (mTOR) in the collecting duct as a determinant of transporter/channel profile and function
Insulinoma and Tuberous Sclerosis: A possible mechanistic target of Rapamycin (mTOR) pathway abnormality?
Diagnostic significance of phosphoinositide 3-kinase and mammalian target of Rapamycin complex 1 in preeclampsia
Wild-type phosphatase and tensin homolog deleted on chromosome 10 improved the sensitivity of cells to Rapamycin through regulating phosphorylation of Akt in …
Rapamycin Alleviated the Symptoms of Fat Embolism Syndrome by Modulating Autophagy in a Rat Model
The Role of Mammalian Target of Rapamycin (mTOR) in a Mouse Model of Cerebral Palsy
Effects of Rapamycin and deferoxamin on wound healing after ischemia and hypoxia
Effect of Rapamycin and chloroquine on osteosarcoma
Rapamycin prevents apoptosis of myocardial cells in heart failure rats through up-regulating Akt.
Neurotoxicity of Paclitaxel and Rapamycin in Rat Model with Transient Blood-Brain Barrier Disruption
The influence and significance of Rapamycin on cardiomyocyte autophagy level of early heart failure rat
The effect of Rapamycin on autophagy in human corneal epithelial cells
AB0421 Rapamycin reduces disease activity through restoring regulatory t cell numbers in patients with active refractory rheumatoid arthritis
Mechanisms of Rapamycin inhibition on mTOR and Drug Design
Mammalian Targets of Rapamycin Inhibitors: Temsirolimus and Everolimus
The role of Nrf2 in the anti-cell senescence effect of Rapamycin
Rapamycin preserves the chondrogenic phenotype and suppresses cartilage degrading and inflammatory processes in osteoarthritis
Rapamycin reduced inhibition of Vγ1 γδ T cells towards Vγ4 γδ T cells through down-regulating IL-4
Immunomodulatory Effects of Rapamycin in Xenogeneic Graft Versus Host Disease
Congenital Hyperinsulinism; Effects of Rapamycin on Min6 Pancreatic β-Cell Line
EFFECTS OF Rapamycin ON AIRWAY INFLAMMATION IN A MOUSE MODEL OF ASTHMA IN REMISSION
Rule-Based Modeling Project of Insulin-Like Growth Factor and Mechanistic Target of Rapamycin Signaling Network with Site-Specific Interactions
Rapamycin as a Novel Therapeutic for Alzheimer’s Disease: Prevention Assessed Through Neuroimaging
Adsorption of a tumor-associated antigen onto crystalized Rapamycin nanoparticles for combined immuno-and antitumor therapy
S23 Evaluation of phosphorylated protein kinase b (akt) and mammalian target of Rapamycin (mTOR) expression in malignant pleural mesothelioma (mpm) and their …
FK506 and Rapamycin Bioconjugation: A Proposal to Increase the Viability of Transplanted Pancreatic Islets
Role of mammalian target of Rapamycin protein in oxidative stress-induced lung injury and pulmonary fibrosis in immature rats
The Role of Rapamycin‐Insensitive mTOR Signaling in the Regulation of Muscle Protein Synthesis in a Rat Model of Resistance Exercise
Protective Effect of Rapamycin against Mitochondrial Injury in an Aging Parkinson’s Disease Mouse Model
Investigation of the clinical predictors of in-stent restenosis after Rapamycin-eluting coronary stent implantation
Activation of phosphoinositide 3-kinase/Akt/mechanistic target of Rapamycin pathway and response to everolimus in endocrine receptor-positive metastatic …
CIP2A can be a therapeutic target of Rapamycin in radioresistant head and neck cancer with P53 mutation
Effect of Rapamycin on proliferation, apoptosis and cell cycles of high glucose-cultured rat glomerular mesangial cell
Rapamycin Interacts with Nutrition to Decrease Basal Metabolic Rate of Drosophila melanogaster
Regulatory effect of Rapamycin on key genes of circadian rhythm in senescent cells
Antifibrotic effect of Rapamycin, an inhibitor of mTOR pathway, on the TGF-β2 induced proliferation of human tenon fibroblasts
NBR1 and KIF14 Downstream of the Mammarian Target of Rapamycin Pathway Predict Recurrence in Nonmuscle Invasive Low Grade Urothelial Carcinoma …
Expression of signaling pathway of mammalian target of Rapamycin in articular cartilage cell induced by interleukin 1β
Improvement in Renal Cystic Disease of Tuberous Sclerosis Complex After Treatment with Mammalian Target of Rapamycin Inhibitor
Abstract P340: Immunomodulatory Effect of Rapamycin on the Expression of Anti-inflammatory Cytokines in Npr1 Gene-deleted Mice
Age-Specific Prolongation of Graft Survival in Recipients Treated With Rapamycin is Linked to CD4+ IFN-g+ IL-10+ Cells
Establishment and Application of HPLC Method for Content Determination of Rapamycin in Human Monocyte THP-1 Derived Foam Cells
Effects of Rapamycin preconditioning on lung injury induced by limb ischemia-reperfusion in rats
The protective effect of Rapamycin on beta-amyloid protein 25-35-induced PC12 cells death
Effect of Rapamycin treatment during postâ activation and/or in vitro culture on embryonic development after parthenogenesis and in vitro fertilization in pigs
Therapeutic effect of edaravone combined with Rapamycin on neural injury in rats with subarachnoid hem-orrhage
Rapamycin-Fortified Diet Delays Wound Repair, Alters CD4+ & γδ+ Splenocyte, CD3+ Thymocyte Distributions in Mice
Toxic effect of Rapamycin in a young rat model of pentylenetetrazole-induced Kindling epilepsy
Cell-intrinsic PD-L1 directs tumor initiating cell fate and Rapamycin and interferon-γ response
Short-term Rapamycin persistently improves cardiac function after cessation of treatment in aged male and female mice.
Combination of Rapamycin and crizotinib induces partial remission of pleural mesothelioma in a patient-derived xenograft model
Mammalian Target Of Rapamycin Is A Key Molecule For Eosinophil Differentiation In Bone Marrow
… communities of developing countries. In the national project entitled: TREATMENT OF BETA-THALASSEMIA PATIENTS WITH Rapamycin (SIROLIMUS): FROM PRE …
Rapamycin suppresses ErbB2-overexpressing mammary tumors through selective inhibition of luminal progenitor cells and tumor-initiating cells
361 Focal adhesion kinase–mammalian target of Rapamycin pathway–mediated different proliferation, migration, and differentiation abilities of satellite cells in Lantang …
Is phosphatidylinositol 3-kinase/AKT/mammalian target of Rapamycin pathway therapeutic target for esophageal adenocarcinoma
Rapamycin-loaded nanoporous α-Fe₂O₃ as an endothelial favorable and thromboresistant coating for biodegradable drug-eluting Fe stent applications
Identification of the mechanistic target of Rapamycin complex 2-associated interactome involved in brain cancer cell motility by affinity purification-mass spectrometry
Advances in lack of amino acid-mediated autophagy via mammalian target of Rapamycin complex 1 signal pathway.
Nicotine inhibits Rapamycin-induced hyperalgesia in na? ve mice via activating mTORC1/S6K/IRS-1-related feedback inhibition loop
Autophagy-inducer Rapamycin alleviates malnutrition-associated liver steatosis: The role of autophagy in malnutrition induced liver damage
The Analyses Of Alveolar Epithelial Injury Through The Lipid Metabolic Stress In The Mammalian Target Of Rapamycin Inhibitor Induced Lung Disease
Abstract P209: Mechanistic Target of Rapamycin Complex 1 (mTORC1) Signaling Generates Reactive Oxygen Species in Mouse Endothelial Cells via NFkB …
Study on the regulation of mammalian target of Rapamycin complex 1 (mTORC1) by nudix-type motif 2 (NUDT2) in cancer cells
The Mammalian Target of Rapamycin and DNA methyltransferase 1 axis mediates vascular endothelial dysfunction in response to disturbed flow
… Control Conventional T-Cells While Supporting Treg Reconstitution Post-Transplant: Long-Term GVHD-Free Survival by Combining OX40L Blockade with Rapamycin
Induction of miR-302a by Rapamycin Protects Human Pluripotent Stem Cells Derived Cardiomyocytes Against Simulated Ischemia/Reoxygenation Injury Under …
CALCINEURIN INHIBITOR WITHDRAWAL AND CONVERSION TO MAMMALIAN TARGET OF Rapamycin INHIBITOR (EVEROLIMUS) IN PEDIATRIC …
… acid (M4N) broadly suppresses cancer metabolism and synergistically induces strong anticancer activity in combination with etoposide, Rapamycin and UCN-01
… DRIVING FIBROSIS: The Analyses Of Alveolar Epithelial Injury Through The Lipid Metabolic Stress In The Mammalian Target Of Rapamycin Inhibitor Induced Lung …
Statement of Retraction. A Central Role for Neuronal AMP-Activated Protein Kinase (AMPK) and Mammalian Target of Rapamycin (mTOR) in High-Protein Diet …
Down‐Regulation of OATP1B1‐Mediated Transport by Mammalian Target of Rapamycin (mTOR) Inhibitors Everolimus and Sirolimus: Potential Mechanism and …
B-cell activating factor involved in the pathogenesis of lupus nephritis through regulating phosphoino-sitide 3-kinase/protein kinase B/mammalian target of Rapamycin …
… systemic lupus erythematosus is mainly associated with the decreased number of regulatory t cells and low-dose il-2 combined with Rapamycin can efficiently recovery …
Correlation of metastasis associated gene-1 and mammalian target of Rapamycin expression with clinical pathology in rectal cancer
Microrna-25 Binds To Tuberous Sclerosis Complex 1 To Modulate Airway Smooth Muscle Proliferation Via Mammalian Target Of Rapamycin Signaling Pathway
MP06-07 CD4+IFN-γ+IL-10+ CELLS FACILITATE A PROLONGATION OF GRAFT SURVIVAL IN OLD RECIPIENT MICE TREATED WITH Rapamycin
LSC-2017-RNA-Seq analysis reveals major differences between the effects of Rapamycin and dual mTORC1/2 inhibition during TGFß1-induced myofibroblast …
P01. 31 Mammalian target of Rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death
Expression of Phosphatidylinositol 3-Kinase, Protein Kinase B and Mammalian Target of Rapamycin in Substan-tia Nigra in Rats with Parkinson’s Disease
The effects and regulation of the Wnt inhibitor Dickkopf-1 and the mechanistic target of Rapamycin in osteotropic cancers
… Kinase Kinase Kinase Kinase-3 (MAP4K3) in Preterm Skeletal Muscle Satellite Cell Myogenesis and Mammalian Target of Rapamycin Complex 1 (mTORC1) …
Immune tolerance to recombinant immunotoxin LMB-100 using synthetic vaccine particles encapsulating Rapamycin
Induction of immune tolerance to recombinant immunotoxin LMB-100 using synthetic vaccine particles encapsulating Rapamycin
The target of Rapamycin and mechanisms of cell growth
Rapamycin and Alzheimer’s disease: time for a clinical trial?
Rapamycin for longevity: opinion article
Rapamycin activates mammalian microautophagy
Rapamycin and Alzheimer disease: a double-edged sword?
Rapamycin, proliferation and geroconversion to senescence
Rapamycin-inspired macrocycles with new target specificity
Recent discoveries on the role of TOR (Target of Rapamycin) signaling in translation in plants
Rapamycin and treatment of venous malformations
Mechanistic target of Rapamycin complex 1 and 2 in human temporal lobe epilepsy
Cell cycle control by the target of Rapamycin signalling pathway in plants
Rapamycin improves healthspan but not inflammaging in nfκb1−/− mice
Rapamycin: a bacteria-derived immunosuppressant that has anti-atherosclerotic effects and its clinical application
ETV7 is an essential component of a Rapamycin-insensitive mTOR complex in cancer
The role of the mammalian target of Rapamycin (mTOR) in pulmonary fibrosis
Target of Rapamycin signaling orchestrates growth–defense trade‐offs in plants
Rapamycin for the aging skin
Promising effect of Rapamycin on multiple sclerosis
Rapamycin in ischemic stroke: Old drug, new tricks?
Rapamycin‐insensitive mechanistic target of Rapamycin regulates basal and resistance exercise‐induced muscle protein synthesis
Effect of caloric restriction and Rapamycin on ovarian aging in mice
Mechanistic target of Rapamycin–independent antidepressant effects of (R)-ketamine in a social defeat stress model
Rapamycin administration is not a valid therapeutic strategy for every case of mitochondrial disease
A novel Rapamycin analog is highly selective for mTORC1 in vivo
Effects of Rapamycin on growth hormone receptor knockout mice
Rapamycin improves the neuroprotection effect of inhibition of NLRP3 inflammasome activation after TBI
Comparison of folate-conjugated Rapamycin versus unconjugated Rapamycin in an orthologous mouse model of polycystic kidney disease
Mechanistic target of Rapamycin (mTOR) pathway, focal cortical dysplasia and epilepsy
Target of Rapamycin kinase: Central regulatory hub for plant growth and metabolism
A Rapamycin-activated caspase 9-based suicide gene
Fasting and Rapamycin: diabetes versus benevolent glucose intolerance
Lung function response and side effects to Rapamycin for lymphangioleiomyomatosis: a prospective national cohort study
A randomized control trial to establish the feasibility and safety of Rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive …
Rapamycin protects against peritendinous fibrosis through activation of autophagy
Rapamycin enhances mitophagy and attenuates apoptosis after spinal ischemia-reperfusion injury
Protective effects of the mechanistic target of Rapamycin against excess iron and ferroptosis in cardiomyocytes
Rapamycin inhibits proliferation and induces autophagy in human neuroblastoma cells
Resistance exercise-induced hypertrophy: a potential role for Rapamycin-insensitive mTOR
Rapamycin modulates tissue aging and lifespan independently of the gut microbiota in Drosophila
Efficacy and safety of topical Rapamycin in patients with facial angiofibromas secondary to tuberous sclerosis complex: the TREATMENT randomized clinical trial
Antigen-selective modulation of AAV immunogenicity with tolerogenic Rapamycin nanoparticles enables successful vector re-administration
A Rapamycin-based GMP-compatible process for the isolation and expansion of regulatory T cells for clinical trials
Rapamycin increases oxidative metabolism and enhances metabolic flexibility in human cardiac fibroblasts
Novel roles of mechanistic target of Rapamycin signaling in regulating fetal growth
Rapamycin treatment for amyotrophic lateral sclerosis: Protocol for a phase II randomized, double-blind, placebo-controlled, multicenter, clinical trial (RAP …
Rapamycin rescues mitochondrial myopathy via coordinated activation of autophagy and lysosomal biogenesis
Topical Rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial
Combination of melatonin and Rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis …
Rapamycin combined with MCC950 to treat multiple sclerosis in experimental autoimmune encephalomyelitis
Rapamycin protects aging muscle
Rapamycin improves insulin resistance and hepatic steatosis in type 2 diabetes rats through activation of autophagy
inhibition of mTOR signaling and clinical activity of Rapamycin in head and neck cancer in a window of opportunity trial
Multiple critical periods for Rapamycin treatment to correct structural defects in Tsc-1-suppressed brain
Mammalian target of Rapamycin as a therapeutic target in osteoporosis
Transcriptional and epigenetic regulation by the mechanistic target of Rapamycin complex 1 pathway
Rapamycin ameliorates lipopolysaccharide-induced acute lung injury by inhibiting IL-1β and IL-18 production
Efficacy of Rapamycin in modulating autophagic activity of Botrytis cinerea for controlling gray mold
Target of Rapamycin inhibition in Chlamydomonas reinhardtii triggers de novo amino acid synthesis by enhancing nitrogen assimilation
Intranasal Rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome
Mutations in PI3K110δ cause impaired natural killer cell function partially rescued by Rapamycin treatment
Target of Rapamycin, a master regulator of multiple signalling pathways and a potential candidate gene for crop improvement
Effects of Rapamycin and curcumin on inflammation and oxidative stress in vitro and in vivo—in search of potential anti-epileptogenic strategies for temporal …
Oncogenic signalling through mechanistic target of Rapamycin (mTOR): A driver of metabolic transformation and cancer progression
Effects of Rapamycin on social interaction deficits and gene expression in mice exposed to valproic acid in utero
Negative effects of chronic Rapamycin treatment on behavior in a mouse model of fragile X syndrome
Long term Rapamycin treatment improves mitochondrial DNA quality in aging mice
Mechanistic target of Rapamycin (mTOR) signaling in status epilepticus
Functional characterization of target of Rapamycin signaling in Verticillium dahliae
Targeting mTOR with MLN0128 overcomes Rapamycin and chemoresistant primary effusion lymphoma
Does Rapamycin slow down time?
Mechanistic/mammalian target of Rapamycin: recent pathological aspects and inhibitors
Mechanistic target of Rapamycin complex 1 signaling modulates vascular endothelial function through reactive oxygen species
E-selectin targeted immunoliposomes for Rapamycin delivery to activated endothelial cells
Metformin reduces glucose intolerance caused by Rapamycin treatment in genetically heterogeneous female mice
Topical use of mammalian target of Rapamycin inhibitors in dermatology: A systematic review with meta-analysis
Therapeutic control of leishmaniasis by inhibitors of the mammalian target of Rapamycin
Multifunctional platinum@ BSA–Rapamycin nanocarriers for the combinatorial therapy of cerebral cavernous malformation
Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR
Rapamycin retards epigenetic ageing of keratinocytes independently of its effects on replicative senescence, proliferation and differentiation
Effect of mycophenolate and Rapamycin on renal fibrosis in lupus nephritis
Rapamycin and fasting sustain autophagy response activated by ischemia/reperfusion injury and promote retinal ganglion cell survival
Neuroprotective effects of Rapamycin on spinal cord injury in rats by increasing autophagy and Akt signaling
Therapeutic activation of autophagy by combined treatment with Rapamycin and trehalose in a mouse MPTP-induced model of Parkinson’s disease
Rapalogs potential as practical alternatives to Rapamycin
Purkinje cells derived from TSC patients display hypoexcitability and synaptic deficits associated with reduced FMRP levels and reversed by Rapamycin
Nanoparticle ferritin-bound erastin and Rapamycin: a nanodrug combining autophagy and ferroptosis for anticancer therapy
Repeated systemic treatment with Rapamycin affects behavior and amygdala protein expression in rats
Sleep-deprived cognitive impairment in aging mice is alleviated by Rapamycin
Rapamycin attenuates mitochondrial injury and renal tubular cell apoptosis in experimental contrast-induced acute kidney injury in rats
Metformin synergizes with Rapamycin to inhibit the growth of pancreatic cancer in vitro and in vivo
Hyaluronate/lactoferrin layer-by-layer-coated lipid nanocarriers for targeted co-delivery of Rapamycin and berberine to lung carcinoma
Rapamycin prevents cerebral stroke by modulating apoptosis and autophagy in penumbra in rats
Target of Rapamycin (TOR) regulates the expression of lncRNAs in response to abiotic stresses in cotton
Rapamycin increases collateral circulation in rodent brain after focal ischemia as detected by multiple modality dynamic imaging
Rapamycin is not protective against ischemic and cisplatin-induced kidney injury
Target of Rapamycin inhibitors (TOR‐I; sirolimus and everolimus) for primary immunosuppression in kidney transplant recipients
Significance and mechanism of androgen receptor overexpression and androgen receptor/mechanistic target of Rapamycin cross‐talk in hepatocellular carcinoma
Regulation of dendritic cell immune function and metabolism by cellular nutrient sensor mammalian target of Rapamycin (mTOR)
The target of Rapamycin kinase affects biomass accumulation and cell cycle progression by altering carbon/nitrogen balance in synchronized Chlamydomonas …
Disease evolution and response to Rapamycin in activated phosphoinositide 3-kinase δ syndrome: the european society for immunodeficiencies-activated …
Rapamycin as an adjunctive therapy for NLRC4 associated macrophage activation syndrome
Rapamycin prevents thoracic aortic aneurysm and dissection in mice
Caloric restriction and Rapamycin differentially alter energy metabolism in yeast
Investigating the effect of target of Rapamycin kinase inhibition on the Chlamydomonas reinhardtii phosphoproteome: from known homologs to new targets
Outcomes associated with mammalian target of Rapamycin (mTOR) inhibitors in heart transplant recipients: A meta-analysis
The use of Rapamycin in patients with tuberous sclerosis complex: Long-term results
Discovery of novel dual histone deacetylase and mammalian target of Rapamycin target inhibitors as a promising strategy for cancer therapy
Self-assembled amphiphilic zein-lactoferrin micelles for tumor targeted co-delivery of Rapamycin and wogonin to breast cancer
Advanced glycation end‐products suppress autophagic flux in podocytes by activating mammalian target of Rapamycin and inhibiting nuclear translocation of …
Rapamycin rescues age-related changes in muscle-derived stem/progenitor cells from progeroid mice
Farnesyltransferase inhibitor and Rapamycin correct aberrant genome organisation and decrease DNA damage respectively, in Hutchinson–Gilford progeria …
Platelet membrane-coated nanoparticle-mediated targeting delivery of Rapamycin blocks atherosclerotic plaque development and stabilizes plaque in apolipoprotein …
Combined treatment with doxorubicin and Rapamycin is effective against in vitro and in vivo models of human glioblastoma
Mammalian target of Rapamycin inhibition attenuates myocardial ischaemia–reperfusion injury in hypertrophic heart
Rapamycin for refractory discoid lupus erythematosus
Anti-fibrotic effects of pirfenidone and Rapamycin in primary IPF fibroblasts and human alveolar epithelial cells
Use of topical Rapamycin in the treatment of superficial lymphatic malformations
Hybrid electrospun Rapamycin-loaded small-diameter decellularized vascular grafts effectively inhibit intimal hyperplasia
Efficacy and safety of mTOR inhibitors (Rapamycin and its analogues) for tuberous sclerosis complex: a meta-analysis
Rapamycin prevents surgery-induced immune dysfunction in patients with bladder cancer
Rapamycin-induced autophagy protects proximal tubular renal cells against proteinuric damage through the transcriptional activation of the nerve growth factor …
Synthesis and application of light-switchable arylazopyrazole Rapamycin analogs
Phase II Study of BEZ235 versus Everolimus in Patients with Mammalian Target of Rapamycin Inhibitor‐Naïve Advanced Pancreatic Neuroendocrine Tumors
Mood-stabilizing effects of Rapamycin and its analog temsirolimus: relevance to autophagy
Target of Rapamycin complex 2–dependent phosphorylation of the coat protein Pan1 by Akl1 controls endocytosis dynamics in Saccharomyces cerevisiae
Investigation of novel regulation of N-myristoyltransferase by mammalian target of Rapamycin in breast cancer cells
Regulation of GSK3 cellular location by FRAT modulates mTORC1-dependent cell growth and sensitivity to Rapamycin
Mechanistic target of Rapamycin inhibitors: successes and challenges as cancer therapeutics
Dual roles of mammalian target of Rapamycin in regulating liver injury and tumorigenesis in autophagy‐defective mouse liver
Rapamycin protects skin fibroblasts from ultraviolet B-induced photoaging by suppressing the production of reactive oxygen species
Effects of Rapamycin on the mechanistic target of Rapamycin (mTOR) pathway and telomerase in breast cancer cells
Ponatinib combined with Rapamycin causes regression of murine venous malformation
Restoration of aberrant mTOR signaling by intranasal Rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down …
Rapamycin for lymphangioleiomyomatosis: optimal timing and optimal dosage
Rapamycin removes damaged mitochondria and protects human trabecular meshwork (TM-1) cells from chronic oxidative stress
Rapamycin mitigates erythrocyte membrane transport functions and oxidative stress during aging in rats
Estimating the concentration of therapeutic range using disease-specific iPS cells: low-dose Rapamycin therapy for Pendred syndrome
Comparative transcriptomic profile of tolerogenic dendritic cells differentiated with vitamin D3, dexamethasone and Rapamycin
A binding site hotspot map of the fkbp12–Rapamycin–frb ternary complex by photoaffinity labeling and mass spectrometry-based proteomics
Protective effect of Rapamycin on endothelial-to-mesenchymal transition in HUVECs through the Notch signaling pathway
Mammalian target of Rapamycin at the crossroad between Alzheimer’s disease and diabetes
… stem cells protect against hypoxia‐ischemia brain damage by enhancing autophagy through brain derived neurotrophic factor/mammalin target of Rapamycin …
Mammalian target of Rapamycin inhibition in Trypanosoma cruzi-infected macrophages leads to an intracellular profile that is detrimental for infection
Saccharomyces cerevisiae adapted to grow in the presence of low-dose Rapamycin exhibit altered amino acid metabolism
Rapamycin attenuates high glucose-induced inflammation through modulation of mTOR/NF-κB pathways in macrophages
The mechanistic target of Rapamycin (mTOR) and the silent mating-type information regulation 2 homolog 1 (SIRT1): oversight for neurodegenerative disorders
Rapamycin reduces podocyte apoptosis and is involved in autophagy and mTOR/P70S6K/4EBP1 signaling
inhibition of mTOR by Rapamycin Aggravates Corneal Epithelial Stem Cell Deficiency by Upregulating Inflammatory Response
Rapamycin‑induced miR‑30a downregulation inhibits senescence of VSMCs by targeting Beclin1
The impairments of α-synuclein and mechanistic target of Rapamycin in rotenone-induced SH-SY5Y cells and mice model of Parkinson’s disease
Berunda polypeptides: biheaded Rapamycin carriers for subcutaneous treatment of autoimmune dry eye disease
Rapamycin confers neuroprotection against aging-induced oxidative stress, mitochondrial dysfunction, and neurodegeneration in old rats through activation of …
Antileishmanial effect of Rapamycin as an alternative approach to control Leishmania tropica infection
Reduced menin expression impairs Rapamycin effects as evidenced by an increase in mTORC2 signaling and cell migration
Rapamycin modulates glucocorticoid receptor function, blocks atrophogene REDD1, and protects skin from steroid atrophy
Depletion of NBR1 in urothelial carcinoma cells enhances Rapamycin‐induced apoptosis through impaired autophagy and mitochondrial dysfunction
The effect of Rapamycin treatment on cerebral ischemia: A systematic review and meta-analysis of animal model studies
Endoplasmic reticulum stress-induced apoptosis in intestinal epithelial cells: a feed-back regulation by mechanistic target of Rapamycin complex 1 (mTORC1)
Intravesical delivery of Rapamycin via folate-modified liposomes dispersed in thermo-reversible hydrogel
A Perfect sTORm: the role of the mammalian target of Rapamycin (mTOR) in cerebrovascular dysfunction of alzheimer’s disease: a mini-review
Rapamycin relieves inflammation of experimental autoimmune encephalomyelitis by altering the balance of Treg/Th17 in a mouse model
… of cardiac miRNA Transcriptomes induced by diabetes and Rapamycin treatment and identification of a Rapamycin-associated cardiac MicroRNA signature
Behavioral conditioning of anti-proliferative and immunosuppressive properties of the mTOR inhibitor Rapamycin
Therapeutic suppression of mTOR (mammalian target of Rapamycin) signaling prevents and reverses salt-induced hypertension and kidney injury in dahl salt-sensitive …
Enhanced supply of methionine or arginine alters mechanistic target of Rapamycin signaling proteins, messenger RNA, and microRNA abundance in heat …
New mammalian target of Rapamycin (mTOR) modulators derived from natural product databases and marine extracts by using molecular docking techniques
Hypervascularization in mTOR‐dependent focal and global cortical malformations displays differential Rapamycin sensitivity
Acute and chronic Rapamycin use in patients with fibrodysplasia ossificans progressiva: a report of two cases
Melatonin and Rapamycin attenuate isoflurane-induced cognitive impairment through inhibition of neuroinflammation by suppressing the mTOR signaling in …
Intracellular delivery of Rapamycin from FKBP elastin-like polypeptides is consistent with macropinocytosis
The regulation of Rapamycin in planarian Dugesia japonica Ichikawa & Kawakatsu, 1964 regeneration according to TOR signaling pathway
Liraglutide ameliorates cognitive decline by promoting autophagy via the AMP-activated protein kinase/mammalian target of Rapamycin pathway in a streptozotocin …
Rapamycin, an immunosuppressant and mTORC1 inhibitor, triples the antidepressant response rate of ketamine at 2 weeks following treatment: a double-blind …
Combined ischemic and Rapamycin preconditioning alleviated liver ischemia and reperfusion injury by restoring autophagy in aged mice
… maintaining the ratios of Thr: Phe, Lys: Thr, Lys: His, and Lys: Val alters mammary cellular metabolites, mammalian target of Rapamycin signaling, and gene …
Target of Rapamycin‐signaling modulates starch accumulation via glycogenin phosphorylation status in the unicellular red alga Cyanidioschyzon merolae
Metformin ameliorates experimental diabetic periodontitis independently of mammalian target of Rapamycin (mTOR) inhibition by reducing NIMA‐related kinase 7 …
Rapamycin Induced Autophagy Inhibits Inflammation‐Mediated Endplate Degeneration by Enhancing Nrf2/Keap1 Signaling of Cartilage Endplate Stem Cells
Local release of Rapamycin by microparticles delays islet rejection within the anterior chamber of the eye
High glucose-induced podocyte injury involves activation of mammalian target of Rapamycin (mTOR)-induced endoplasmic reticulum (ER) stress
Hippocampal mammalian target of Rapamycin is implicated in stress-coping behavior induced by cannabidiol in the forced swim test
Label-free single-molecule quantification of Rapamycin-induced FKBP–FRB dimerization for direct control of cellular mechanotransduction
Rapamycin-loaded polysorbate 80-coated PLGA nanoparticles: Optimization of formulation variables and in vitro anti-glioma assessment
Synergistic clearance of intracellular pathogens by hyaluronan-streptomycin micelles encapsulated with Rapamycin
Protective effect of a mechanistic target of Rapamycin inhibitor on an in vivo model of cisplatin-induced ovarian gonadotoxicity
Layer-by-layer gelatin/chondroitin quantum dots-based nanotheranostics: combined Rapamycin/celecoxib delivery and cancer imaging
Rapamycin for inclusion body myositis: targeting non-inflammatory mechanisms
Role of mammalian target of Rapamycin in atherosclerosis
Rapamycin mediates mTOR signaling in reactive astrocytes and reduces retinal ganglion cell loss
Cardioprotective effects of dietary Rapamycin on adult female C57BLKS/J-Leprdb mice
Blockade of Treg cell differentiation and function by the interleukin‐21–mechanistic target of Rapamycin axis via suppression of autophagy in patients with systemic …
Rapamycin attenuates Tc1 and Tc17 cell responses in cigarette smoke-induced emphysema in mice
Mammalian target of Rapamycin inhibitors combined with calcineurin inhibitors as initial immunosuppression in renal transplantation: a meta-analysis
Differential effects of Rapamycin on Bursaphelenchus xylophilus with different virulence and differential expression of autophagy genes under stresses in nematodes
Impacting dementia and cognitive loss with innovative strategies: mechanistic target of Rapamycin, clock genes, circular non-coding ribonucleic acids, and …
Rapamycin Supplementation May Ameliorate Erectile Function in Rats With Streptozotocin–Induced Type 1 Diabetes by Inducing Autophagy and Inhibiting Apoptosis …
Glycol Chitosan-Docosahexaenoic Acid Liposomes for Drug Delivery: Synergistic Effect of Doxorubicin-Rapamycin in Drug-Resistant Breast Cancer
Alteration of the Wnt/GSK3β/β‑catenin signalling pathway by Rapamycin ameliorates pathology in an Alzheimer’s disease model
Preconditioning of umbilical cord‐derived mesenchymal stem cells by Rapamycin increases cell migration and ameliorates liver ischaemia/reperfusion injury in mice …
Rapamycin and fingolimod modulate Treg/Th17 cells in experimental autoimmune encephalomyelitis by regulating the Akt-mTOR and MAPK/ERK pathways
Rapamycin loaded TPGS-Lecithins-Zein nanoparticles based on core-shell structure for oral drug administration
A study on the mechanism of Rapamycin mediating the sensitivity of pancreatic cancer cells to cisplatin through PI3K/AKT/mTOR signaling pathway
Transcriptome of white shrimp Litopenaeus vannamei induced with Rapamycin reveals the role of autophagy in shrimp immunity
… supply during the periparturient period enhances insulin signaling, amino acid transporters, and mechanistic target of Rapamycin pathway proteins in adipose …
Rapamycin synergizes with cisplatin in antiendometrial cancer activation by improving il-27–stimulated cytotoxicity of nk cells
Cinobufagin suppresses colorectal cancer angiogenesis by disrupting the endothelial mammalian target of Rapamycin/hypoxia‐inducible factor 1α axis
Rapamycin upregulates connective tissue growth factor expression in hepatic progenitor cells through TGF-β-Smad2 dependent signaling
Rapamycin induces autophagy to alleviate acute kidney injury following cerebral ischemia and reperfusion via the mTORC1/ATG13/ULK1 signaling pathway
Metabolic shift induced by ω-3 PUFAs and Rapamycin lead to cancer cell death
Mammalian target of Rapamycin complex 2 (mTORC2) controls glycolytic gene expression by regulating Histone H3 Lysine 56 acetylation
Rapamycin enhances growth inhibition on urothelial carcinoma cells through LKB1 deficiency‐mediated mitochondrial dysregulation
Mechanistic target of Rapamycin complex 1 promotes the expression of genes encoding electron transport chain proteins and stimulates oxidative …
… stress affects muscle hypertrophy, muscle protein synthesis and uptake of amino acid in broilers via insulin like growth factor-mammalian target of Rapamycin …
Mammalian target of Rapamycin complex 1 signaling is required for the dedifferentiation from biliary cell to bipotential progenitor cell in zebrafish liver regeneration
Melatonin protects against streptozotocin-induced diabetic cardiomyopathy through the mammalian target of Rapamycin (mTOR) signaling pathway
Self-assembled amphiphilic-dextran nanomicelles for delivery of Rapamycin
Controversies on the potential therapeutic use of Rapamycin for treating a lysosomal cholesterol storage disease
Involvement of pro-inflammation signal pathway in inhibitory effects of Rapamycin on oxaliplatin-induced neuropathic pain
Direct targeting of the mTOR (mammalian target of Rapamycin) kinase improves endothelial permeability in drug-eluting stents—brief report
… , a novel nerve poison, triggers neuronal autophagic death via reactive oxygen species-mediated inhibition of the protein kinase B/mammalian target of Rapamycin …
Oligo (lactic acid) 8-Rapamycin prodrug-loaded poly (ethylene glycol)-block-poly (lactic acid) micelles for injection
New metformin derivative HL 156A prevents oral cancer progression by inhibiting the insulin‐like growth factor/AKT/mammalian target of Rapamycin pathways
Mammalian target of Rapamycin complex 1 and its downstream effector collapsin response mediator protein‐2 drive reinstatement of alcohol reward seeking
Lysosome membrane permeabilization and disruption of the molecular target of Rapamycin (mTOR)-lysosome interaction are associated with the inhibition of lung …
Effects of mammalian target of Rapamycin on proliferation, apoptosis and differentiation of myoblasts undergoing mechanical stress
Low dose of IL-2 combined with Rapamycin restores and maintains the long-term balance of Th17/Treg cells in refractory SLE patients
Amino acids stimulate glycyl‐tRNA synthetase nuclear localization for mammalian target of Rapamycin expression in bovine mammary epithelial cells
Sodium fluoride induces splenocyte autophagy via the mammalian targets of Rapamycin (mTOR) signaling pathway in growing mice
Role of mammalian target of Rapamycin in regulating HIF-1α and vascular endothelial growth factor signals in glaucoma
Glucosamine promotes osteoblast proliferation by modulating autophagy via the mammalian target of Rapamycin pathway
Rapamycin inhibits ox-LDL-induced inflammation in human endothelial cells in vitro by inhibiting the mTORC2/PKC/c-Fos pathway
Rapamycin enhanced the antitumor effects of doxorubicin in myelogenous leukemia K562 cells by downregulating the mTOR/p70S6K pathway
… acids affect jejunal cell proliferation and functions by affecting antioxidant capacity, Wnt/β-catenin, and the mechanistic target of Rapamycin signaling pathways in …
Mammalian target of Rapamycin 2 (mTOR2) and C-MYC modulate glucosamine-6-phosphate synthesis in glioblastoma (GBM) cells through glutamine: fructose-6 …
Rapamycin inhibits activation of AMPK-mTOR signaling pathway-induced Alzheimer’s disease lesion in hippocampus of rats with type 2 diabetes mellitus
The protective effects of Rapamycin on cell autophagy in the renal tissues of rats with diabetic nephropathy via mTOR-S6K1-LC3II signaling pathway
Rapamycin alleviates proinflammatory cytokines and nociceptive behavior induced by chemotherapeutic paclitaxel
… neonatal hypoxic brain injury by reducing oxidative stress and activation of phosphatidylinositol-3-kinase/Akt/mammalian target of Rapamycin (PI3K/Akt/mTOR …
Synthesis and biological evaluation of Rapamycin-derived, next generation small molecules
Rapamycin relieves anxious emotion and synaptic plasticity deficits induced by hindlimb unloading in mice
Rapamycin inhibits peritoneal fibrosis by modifying lipid homeostasis in the peritoneum
Rapamycin prevents the intervertebral disc degeneration via inhibiting differentiation and senescence of annulus fibrosus cells
Rapamycin combined with α-Cyanoacrylate contributes to inhibiting intimal hyperplasia in rat models
Crocin induces anti-ischemia in middle cerebral artery occlusion rats and inhibits autophagy by regulating the mammalian target of Rapamycin
Haploinsufficiency of mechanistic target of Rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish
… -mediated apoptosis in renal cell carcinoma via the p53/AMP‑activated protein kinase/mammalian target of Rapamycin autophagy signaling pathway
Mammalian target of Rapamycin signaling and ubiquitin-proteasome–related gene expression in skeletal muscle of dairy cows with high or normal body …
p53 induces miR‐199a‐3p to suppress mechanistic target of Rapamycin activation in cisplatin‐induced acute kidney injury
… -protective role of metformin in patients with acute stroke and type 2 diabetes mellitus via AMPK/mammalian target of Rapamycin (mTOR) signaling pathway …
Rapamycin modulate Treg/Th17 balance via regulating metabolic pathways: a study in mice
Stomatitis associated with mammalian target of Rapamycin inhibition: a review of pathogenesis, prevention, treatment, and clinical implications for oral practice in …
Proteomic mapping by Rapamycin-dependent targeting of APEX2 identifies binding partners of VAPB at the inner nuclear membrane
Feedback activation of SGK3 and AKT contributes to Rapamycin resistance by reactivating mTORC1/4EBP1 axis via TSC2 in breast cancer
The change of immunosuppressive regimen from calcineurin inhibitors to mammalian target of Rapamycin (mTOR) inhibitors and its effect on malignancy following …
Rapamycin attenuates BAFF‐extended proliferation and survival via disruption of mTORC1/2 signaling in normal and neoplastic B‐lymphoid cells
mTOR inhibitor Rapamycin induce polymorphonuclear myeloid-derived suppressor cells mobilization and function in protecting against acute graft-versus-host disease …
Effect of Rapamycin on bone mass and strength in the α2 (I)‐G610C mouse model of osteogenesis imperfecta
A novel therapeutic approach to colorectal cancer in diabetes: role of metformin and Rapamycin
Mammalian target of Rapamycin (mTOR) and the proteasome attenuates IL-1β expression in primary mouse cardiac fibroblasts
A Rapamycin derivative, biolimus, preferentially activates autophagy in vascular smooth muscle cells
Investigating effect of Rapamycin and metformin on angiogenesis in hepatocellular carcinoma cell line
Sirolimus (Rapamycin) for the targeted treatment of the fibrotic sequelae of Graves’ orbitopathy
Rapamycin nano-micelle ophthalmic solution reduces corneal allograft rejection by potentiating myeloid-derived suppressor cells’ function
Targeting the phosphatidylinositol 3‐kinase/Akt/mechanistic target of Rapamycin signaling pathway in B‐lineage acute lymphoblastic leukemia: An update
Comprehensive analysis of lysine acetylome reveals a site-specific pattern in Rapamycin-induced autophagy
Rapamycin suppresses postnatal muscle hypertrophy induced by myostatin-inhibition accompanied by transcriptional suppression of the Akt/mTOR pathway
Targeting delivery of Rapamycin with anti-collagen IV peptide conjugated Fe3O4@ nanogels system for vascular restenosis therapy
Involvement of phosphatidylinositol-3 kinase/Akt/mammalian target of Rapamycin/peroxisome proliferator-activated receptor γ pathway for induction and maintenance …
MiR‐99a‐5p inhibits bladder cancer cell proliferation by directly targeting mammalian target of Rapamycin and predicts patient survival
T-2 Toxin Exposure Induces Apoptosis in TM3 Cells by Inhibiting Mammalian Target of Rapamycin/Serine/Threonine Protein Kinase (mTORC2/AKT) to Promote Ca2+ …
Targeting the mammalian target of Rapamycin for epileptic encephalopathies and malformations of cortical development
… the levels of autophagy-related genes via adenosine 5′-monophosphate-activated protein kinase/mammalian target of Rapamycin signaling pathway in …
Chronic oral Rapamycin decreases adiposity, hepatic triglycerides and insulin resistance in male mice fed a diet high in sucrose and saturated fat
The sources of essential fatty acids for allergic and cancer patients; a connection with insight into mammalian target of Rapamycin: A narrative review
Challenging the CNS targeting potential of systemically administered nanoemulsion delivery systems: a case study with Rapamycin-containing fish oil nanoemulsions …
Rapamycin inhibited photoreceptor necroptosis and protected the retina by activation of autophagy in experimental retinal detachment
Renal toxicity with mammalian target of Rapamycin inhibitors: A meta-analysis of randomized clinical trials
Organ preservation with targeted Rapamycin nanoparticles: a pre-treatment strategy preventing chronic rejection in vivo
Effect of Rapamycin microspheres in Sjögren syndrome dry eye: preparation and outcomes
Blocking mammalian target of Rapamycin (mTOR) alleviates neuropathic pain induced by chemotherapeutic bortezomib
Rapamycin-mediated mTOR inhibition impairs silencing of sex chromosomes and the pachytene piRNA pathway in the mouse testis
… oxygen species (ROS) production, and inhibition of cell migration and nuclear factor kappa B (Nf-κB)/mammalian target of Rapamycin (m-TOR) signalling …
Rapamycin corrects T regulatory cell depletion and improves embryo implantation and live birth rates in a murine model
The effect of the mTOR inhibitor Rapamycin on glucoCEST signal in a preclinical model of glioblastoma
Neolymphostin A is a covalent phosphoinositide 3-kinase (PI3K)/mammalian target of Rapamycin (mTOR) dual inhibitor that employs an unusual electrophilic …
Nicotine inhibits Rapamycin-induced pain through activating mTORC1/S6K/IRS-1-related feedback inhibition loop
The local mammalian target of Rapamycin (mTOR) modulation: a promising strategy to counteract neurodegeneration
Regulation of YAP by Mammalian Target of Rapamycin Complex 1 in Endothelial Cells Controls Blood Pressure Through COX-2/mPGES-1/PGE2 Cascade
Long‐term treatment with the mTOR inhibitor Rapamycin has minor effect on clinical laboratory markers in middle‐aged marmosets
Androgens induce growth of the limb skeletal muscles in a Rapamycin-insensitive manner
Rapamycin improves bone mass in high-turnover osteoporosis with iron accumulation through positive effects on osteogenesis and angiogenesis
Synergistic effect of Rapamycin and metformin against germ cell apoptosis and oxidative stress after testicular torsion/detorsion-induced ischemia/reperfusion …
Effect and molecular mechanism of mTOR inhibitor Rapamycin on temozolomide‑induced autophagic death of U251 glioma cells
Clinical significance of chemokine receptor CXCR4 and mammalian target of Rapamycin (mTOR) expression in patients with diffuse large B-cell lymphoma
Curcumin inhibits the growth of liver cancer stem cells through the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of Rapamycin signaling …
Delivery of Rapamycin using in situ forming implants promotes immunoregulation and vascularized composite allograft survival
Rapamycin protects spiral ganglion neurons from gentamicin-induced degeneration in vitro
Rapamycin may inhibit murine S180 sarcoma growth by regulating the pathways associated with autophagy and cancer stem cells
Rapamycin ameliorates immune-mediated aplastic anemia by inhibiting the proliferation and metabolism of T cells
Rapamycin attenuates liver injury caused by vinyl chloride metabolite chloroethanol and lipopolysaccharide in mice
Plk1-mediated phosphorylation of TSC1 enhances the efficacy of Rapamycin
Characterization of female germline stem cells from adult mouse ovaries and the role of Rapamycin on them
Rapamycin suppresses angiogenesis and lymphangiogenesis in melanoma by downregulating VEGF-A/VEGFR-2 and VEGF-C/VEGFR-3 expression
Antitumor effect of sorafenib and mammalian target of Rapamycin inhibitor in liver transplantation recipients with hepatocellular carcinoma recurrence
The Slt2-MAPK pathway is involved in the mechanism by which target of Rapamycin regulates cell wall components in Ganoderma lucidum
… to lysine while maintaining an ideal ratio of lysine: methionine alters mammary cellular metabolites, mammalian target of Rapamycin signaling, and gene …
Dissecting the Biological Effects of Isoflurane through the Mechanistic Target of Rapamycin (mTOR) and microRNAs (miRNAs)
Is Rapamycin a rapalog?
Global gene expression of histologically normal primary skin cells from BCNS subjects reveals “single-hit” effects that are influenced by Rapamycin
The checkpoint kinase TOR (target of Rapamycin) regulates expression of a nuclear‐encoded chloroplast RelA‐SpoT homolog (RSH) and modulates chloroplast …
Multifarious biologic loaded liposomes that stimulate the mammalian target of Rapamycin signaling pathway show retina neuroprotection after retina damage
… Carcinoma Tumorigenesis Through Regulating Adenosine‐Monophosphate–Activated Protein Kinase Alpha/Mammalian Target of Rapamycin Axis in Mice
Rapamycin attenuates articular cartilage degeneration by inhibiting β-catenin in a murine model of osteoarthritis
Mechanistic target of Rapamycin inhibition with Rapamycin induces autophagy and correlative regulation in white shrimp (Litopenaeus vannamei)
Targeting cellular metabolism using Rapamycin and/or doxycycline enhances anti-tumour effects in human glioma cells
Rapamycin activates TGF receptor independently of its ligand: implications for endothelial dysfunction
Rapamycin improves sevoflurane‑induced cognitive dysfunction in aged rats by mediating autophagy through the TLR4/MyD88/NF‑κB signaling pathway
Methionine and valine activate the mammalian target of Rapamycin complex 1 pathway through heterodimeric amino acid taste receptor (TAS1R1/TAS1R3) …
Response to Rapamycin analogs but not PD-1 inhibitors in PTEN-mutated metastatic non-small-cell lung cancer with high tumor mutational burden
Aldosterone modulates the mechanistic target of Rapamycin signaling in male mice
Mammalian target of Rapamycin: is it relevant to COPD pathogenesis or treatment?
Testicular injury attenuated by Rapamycin through induction of autophagy and inhibition of endoplasmic reticulum stress in streptozotocin-induced diabetic rats
Eukaryotic Initiation Factor 4E (eIF4E) sequestration mediates 4E-BP1 response to Rapamycin
… carcinoma cell proliferation and migration by inactivating phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of Rapamycin (mTOR) signaling pathway
Akt Serine/Threonine Kinase 1 Regulates de Novo Fatty Acid Synthesis through the Mammalian Target of Rapamycin/Sterol Regulatory Element Binding Protein 1 …
… the synthesis of pancreatic enzymes via the activation of mRNA expression and phosphorylation in the mammalian target of Rapamycin signalling pathways in …
Rapamycin as a potential treatment for succinate dehydrogenase deficiency
Rapamycin treatment increases hippocampal cell viability in an mTOR-independent manner during exposure to hypoxia mimetic, cobalt chloride
Effect of acute aerobic exercise and Rapamycin treatment on autophagy in peripheral blood mononuclear cells of adults with prediabetes
Everolimus, a mammalian target of Rapamycin inhibitor, ameliorated streptozotocin-induced learning and memory deficits via neurochemical alterations in …
Use of mammalian target of Rapamycin inhibitors in patient with autosomal dominant polycystic kidney disease: an updated meta-analysis
Curcumin‑induced promoter hypermethylation of the mammalian target of Rapamycin gene in multiple myeloma cells
A subgroup of pleural mesothelioma expresses ALK protein and may be targetable by combined Rapamycin and crizotinib therapy
Rapamycin treatment attenuates angiotensin II-induced abdominal aortic aneurysm formation via VSMC phenotypic modulation and down-regulation of ERK1/2 …
Addition of the mammalian target of Rapamycin inhibitor, everolimus, to consolidation therapy in acute myeloid leukemia: experience from the UK NCRI AML17 …
Critical role of mammalian target of Rapamycin for IL-10 dendritic cell induction by a flagellin A conjugate in preventing allergic sensitization
Synergistic antitumour effects of Rapamycin and oncolytic reovirus
The contribution of non-essential Schizosaccharomyces pombe genes to fitness in response to altered nutrient supply and target of Rapamycin activity
The plant target of Rapamycin kinase: a connecTOR between sulfur and growth
Graded replacing fishmeal with canola meal in diets affects growth and target of Rapamycin pathway gene expression of juvenile blunt snout bream, Megalobrama …
Mechanistic target of Rapamycin (mTOR) protein expression in the tumor and its microenvironment correlates with more aggressive pathology at cystectomy
“Tandem” Nanomedicine Approach against Osteoclastogenesis: Polysulfide Micelles Synergically Scavenge ROS and Release Rapamycin
… effects on human pancreatic cancer cells by triggering cell cycle arrest, apoptosis, and modulation of AKT/mammalian target of Rapamycin (mTOR) and signal …
Negative feedback loop of autophagy and endoplasmic reticulum stress in Rapamycin protection against renal ischemia‐reperfusion injury during initial reperfusion …
Functional effects of cuprizone-induced demyelination in the presence of the mTOR-inhibitor Rapamycin
Rapamycin-upregulated miR-29b promotes mTORC1-hyperactive cell growth in TSC2-deficient cells by downregulating tumor suppressor retinoic acid receptor β …
… cell activation and liver fibrosis through modulation of intracellular ATP levels and the liver kinase B1/AMP-activated protein kinase/mammalian target of Rapamycin …
Fluorofenidone inhibits UV‐A induced senescence in human dermal fibroblasts via the mammalian target of Rapamycin‐dependent SIRT1 pathway
Rapamycin-and starvation-induced autophagy are associated with miRNA dysregulation in A549 cells
The antidiabetic drug lobeglitazone protects mice from lipogenesis-induced liver injury via mechanistic target of Rapamycin complex 1 inhibition
Protective effects of Rapamycin induced autophagy on CLP septic mice
Searching for potential mTOR inhibitors: Ligand-based drug design, docking and molecular dynamics studies of Rapamycin binding site
Preclinical evidence of the enhanced effectiveness of combined Rapamycin and AICAR in reducing kidney cancer
Chloroquine Enhances Rapamycin-induced Apoptosis in MG63 Cells
Rapamycin promotes the anticancer action of dihydroartemisinin in breast cancer MDA-MB-231 cells by regulating expression of Atg7 and DAPK
Takeda G protein-coupled receptor 5-mechanistic target of Rapamycin complex 1 signaling contributes to the increment of glucagon-like peptide-1 production …
Eriocalyxin B induces apoptosis and autophagy involving Akt/mammalian target of Rapamycin (mTOR) pathway in prostate cancer cells
Rapamycin treatment ameliorates age-related accumulation of toxic metabolic intermediates in brains of the Ts65Dn mouse model of Down syndrome and …
Interplay of autophagy inducer Rapamycin and proteasome inhibitor mg132 in reduction of foam cell formation and inflammatory cytokine expression
Gymnemic acid I triggers mechanistic target of Rapamycin‐mediated β cells cytoprotection through the promotion of autophagy under high glucose stress
Rapamycin ameliorates psoriasis by regulating the expression and methylation levels of tropomyosin via ERK 1/2 and mTOR pathways in vitro and in vivo
l-Leucine influx through Slc7a5 regulates inflammatory responses of human B cells via mammalian target of Rapamycin complex 1 signaling
Target of Rapamycin (TOR) determines appendage size during pupa formation of the red flour beetle Tribolium castaneum
Rapamycin-induced autophagy decreases Myf5 and MyoD proteins in C2C12 myoblast cells
Heterogeneity of phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of Rapamycin activation in cancer: Is PI3K isoform specificity important?
Rapamycin enhances the sensitivity of ER‑positive breast cancer cells to tamoxifen by upregulating p73 expression
inhibition of mammalian target of Rapamycin complex 1 signaling by n-3 polyunsaturated fatty acids promotes locomotor recovery after spinal cord injury
… and new bone formation by cultured adipose tissue-derived stem cells through the IGF-1R/AKT/mammalian target of Rapamycin complex 1 (mTORC1) …
Dysregulated expression of the key effectors of the mammalian target of Rapamycin signalling pathway in cutaneous papillomas of dogs
Rapamycin-Loaded, CapryolTM 90 and Oleic Acid Mediated Nanoemulsions: Formulation Development, Characterization and Toxicity Assessment
Compound C enhances tau phosphorylation at Serine396 via PI3K activation in an AMPK and Rapamycin independent way in differentiated SH-SY5Y cells
The potential effects of hemp seed/evening primrose oils on the mammalian target of Rapamycin complex 1 and interferon-gamma genes expression in …
Rapamycin-independent IGF2 expression in Tsc2-null mouse embryo fibroblasts and human lymphangioleiomyomatosis cells
Identification of novel components of target-of-Rapamycin signaling pathway by network-based multi-omics integrative analysis
Fructose and glucose can regulate mammalian target of Rapamycin complex 1 and lipogenic gene expression via distinct pathways
Deficiency of apoptosis-stimulating protein two of p53 promotes liver regeneration in mice by activating mammalian target of Rapamycin
… mesenchymal stem cells promote head and neck cancer progression through Periostin‐mediated phosphoinositide 3‐kinase/Akt/mammalian target of Rapamycin
Long non‑coding RNA SENCR alleviates the inhibitory effects of Rapamycin on human umbilical vein endothelial cells
Enhanced Rapamycin production through kinetic and purification studies by mutant strain of Streptomyces hygroscopicus NTG-30-27
Prevention of post-ischemic seizure by Rapamycin is associated with deactivation of mTOR and ERK1/2 pathways in hyperglycemic rats
Topical Rapamycin (sirolimus) for the treatment of uncomplicated tufted angiomas in two children and review of the literature
Inhibitory effect of Rapamycin on proliferation of human umbilical arterial smooth muscle cells
Clinically-Relevant Rapamycin Treatment Regimens Enhance CD8+ Effector Memory T Cell Function In The Skin and Allow their Infiltration into Cutaneous …
Mechanistic target of Rapamycin pathway in epileptic disorders
inhibition of the mammalian target of Rapamycin may augment the increase in soluble klotho levels in renal transplantation recipients
… induces apoptosis of estrogen receptor-positive MG-63 osteosarcoma cells via the Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian target of Rapamycin …
Circadian rhythms, metabolic oscillators, and the target of Rapamycin (TOR) pathway: the Neurospora connection
Leucine regulates α-amylase and trypsin synthesis in dairy calf pancreatic tissue in vitro via the mammalian target of Rapamycin signalling pathway
Adrenoceptor regulation of the mechanistic target of Rapamycin in muscle and adipose tissue
Accelerated autophagy of cecal ligation and puncture-induced myocardial dysfunction and its correlation with mammalian target of Rapamycin pathway in rats
A selective CD28 antagonist and Rapamycin synergise to protect against spontaneous autoimmune diabetes in NOD mice
A component of the TOR (Target of Rapamycin) nutrient-sensing pathway plays a role in circadian rhythmicity in Neurospora crassa
… reverses palbociclib resistance in ER+ human breast cancer cells by inhibiting phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of Rapamycin …
… attenuates high glucose-mediated mesangial cell injury by inhibiting the phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin (PI3K/Akt/mTOR) …
Comparing the effects of the mTOR inhibitors azithromycin and Rapamycin on in vitro expanded regulatory T cells
Development and characterisation of a panel of phosphatidylinositide 3-kinase–mammalian target of Rapamycin inhibitor resistant lung cancer cell lines
Rapamycin rescues BMP mediated midline craniosynostosis phenotype through reduction of mTOR signaling in a mouse model
… inhibitor, TUPS, attenuates isoproterenol/angiotensin II‐induced cardiac hypertrophy through mammalian target of Rapamycin‐mediated autophagy inhibition
Pathology of calcineurin and mammalian target of Rapamycin inhibitors in kidney transplantation
Calorie restriction and Rapamycin administration induce stem cell self-renewal and consequent development and production in the mammary gland
Rapamycin exacerbates cardiovascular dysfunction after complete high-thoracic spinal cord injury
Mechanistic target of Rapamycin (mTOR) in the cancer setting
… multicentre randomised post-market trial to assess the safety and effectiveness of the Firehawk cobalt-chromium coronary stent (Rapamycin target-eluting) system for …
Dynamic regulation of caveolin-1 phosphorylation and caveolae formation by mammalian target of Rapamycin complex 2 in bladder cancer cells
Concentration‑dependent effects of Rapamycin on proliferation, migration and apoptosis of endothelial cells in human venous malformation
Effects of long-term Rapamycin treatment on glial scar formation after cryogenic traumatic brain injury in mice
Rapamycin liposome gutta inhibiting fungal keratitis of rats
Successful reversal of ovarian hyperstimulation syndrome in a mouse model by Rapamycin, an mTOR pathway inhibitor
Rapamycin alleviates hormone imbalance-induced chronic nonbacterial inflammation in rat prostate through activating autophagy via the mTOR/ULK1/ATG13 …
The mTOR kinase inhibitor Rapamycin enhances the expression and release of pro-inflammatory cytokine interleukin 6 modulating the activation of human …
… ‐1 Receptor Antagonism Improves Glycemic Control and Increases Energy Expenditure Through Sirtuin‐1/Mechanistic Target of Rapamycin Complex 2 and 5 …
Ethanol-induced cognitive dysfunction is associated with alterations in the mammalian target of Rapamycin signalling pathway in the hippocampus of male mice
Mammalian target of Rapamycin regulates a hyperresponsive state in pulmonary neutrophils late after burn injury
Effect of silencing lncRNATUG1 on Rapamycin‑induced inhibition of endothelial cell proliferation and migration
Mesenchymal stem cells in combination with low-dose Rapamycin significantly prolong islet allograft survival through induction of regulatory T cells
MicroRNA-495 confers increased sensitivity to chemotherapeutic agents in gastric cancer via the mammalian target of Rapamycin (mTOR) signaling pathway …
HPV-16 E7 expression up-regulates phospholipase D activity and promotes Rapamycin resistance in a pRB-dependent manner
Integrin alpha V beta 3 targeted dendrimer‐Rapamycin conjugate reduces fibroblast‐mediated prostate tumor progression and metastasis
Rapamycin provides anti‑epileptogenic effect in a rat model of post‑traumatic epilepsy via deactivation of mTOR signaling pathway
Rapamycin− mTOR+ BRAF=? Using relational similarity to find therapeutically relevant drug-gene relationships in unstructured text
Mammalian target of Rapamycin: A metabolic rheostat for regulating adipose tissue function and cardiovascular health
Efficacy and Tolerance of Sirolimus (Rapamycin) for Extracranial Arteriovenous Malformations in Children and Adults
In vitro evaluation of effects of metformin on morphine and methadone tolerance through mammalian target of Rapamycin signaling pathway
High Glucose Affects the Cytotoxic Potential of Rapamycin, Metformin and Hydrogen Peroxide in Cultured Human Mesenchymal Stem Cells
Amino acid starvation promotes podocyte autophagy through mammalian target of Rapamycin inhibition and transcription factor EB activation
Rapamycin rescues endoplasmic reticulum stress–induced dry eye syndrome in mice
Activation of the mammalian target of Rapamycin signaling pathway underlies a novel inhibitory role of ring finger protein 182 in ventricular remodeling after myocardial …
Rapamycin–“One size does not fit all”
Cross talk networks of mammalian target of Rapamycin signaling with the ubiquitin proteasome system and their clinical implications in multiple myeloma
Rapamycin attenuates Th2-driven experimental allergic conjunctivitis
A combined N-terminomics and shotgun proteomics approach to investigate the responses of human cells to Rapamycin and zinc at the mitochondrial level
Lactobacillus casei protects dextran sodium sulfate-or Rapamycin-induced colonic inflammation in the mouse
… synthetase-mediated essential amino acids regulate β-casein synthesis via cell proliferation and mammalian target of Rapamycin (mTOR) signaling pathway …
MicroRNA-496 and mechanistic target of Rapamycin expression are associated with type 2 diabetes mellitus and obesity in elderly people
… , leucine, methionine, threonine, and other amino acids on insulin and glucagon concentrations, mammalian target of Rapamycin (mTOR) signaling, and …
Retraction: A005, a novel inhibitor of phosphatidylinositol 3-kinase/mammalian target of Rapamycin, prevents osteosarcoma-induced osteolysis.
Rapamycin regulates cholesterol biosynthesis and cytoplasmic ribosomal proteins in hippocampus and temporal lobe of APP/PS1 mouse
Rapamycin attenuates a murine model of thoracic aortic aneurysm by downregulating the miR-126–3p mediated activation of MAPK/ERK signalling pathway
Use of mammalian target of Rapamycin inhibitors for pancreas transplant immunosuppression is associated with improved allograft survival and improved early patient …
Effect of topical Rapamycin 1% on multiple trichoepitheliomas
Activation of mechanistic target of Rapamycin complex 1: the common link between rheumatoid arthritis and diabetes mellitus
Dysplasia and overgrowth: magnetic resonance imaging of pediatric brain abnormalities secondary to alterations in the mechanistic target of Rapamycin pathway
Rapamycin combi with TAE on the growth, metastasis, and prognosis of hepatocellular carcinoma in rat models
Phase I Study of the BRAF Inhibitor Vemurafenib in Combination With the Mammalian Target of Rapamycin Inhibitor Everolimus in Patients With BRAF-Mutated …
Favorable response to mammalian target of Rapamycin inhibition in a young patient with unresectable fibrolamellar carcinoma of the liver
… inhibits colorectal cancer cell proliferation, migration and invasion via TYRO3 and phosphoinositide 3-kinase/protein B kinase/mammalian target of Rapamycin …
… inhibits reactive oxygen species production and apoptosis in primary spinal cord neurons by activating autophagy via the mechanistic target of Rapamycin …
Distinct patterns of gene expression in human cardiac fibroblasts exposed to Rapamycin treatment or methionine restriction
… factor 1α (HIF-1α) promotes autophagy and inhibits Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian target of Rapamycin (mTOR) signaling pathway in …
NR6A1 regulates lipid metabolism through mammalian target of Rapamycin complex 1 in HepG2 cells
… relationship of leucyladenylate sulfamate analogues as leucyl-tRNA synthetase (LRS)-targeting inhibitors of Mammalian target of Rapamycin complex 1 (mTORC1)
Effects of early exposure of isoflurane on chronic pain via the mammalian target of Rapamycin signal pathway
Analyses of alveolar epithelial injury via lipid-related stress in mammalian target of Rapamycin inhibitor-induced lung disease
The role of CIP2A as a therapeutic target of Rapamycin in radioresistant head and neck cancer with TP53 mutation
Effects of NVP‑BEZ235, a dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor, on HTLV-1-infected T-cell lines
… an antidiabetic drug, against ovarian cancer cells involves inhibition of cysteine-rich 61 (Cyr61)/Akt/Mammalian target of Rapamycin (mTOR) signaling pathway
Discovery of novel leucyladenylate sulfamate surrogates as leucyl-tRNA synthetase (LRS)-targeted mammalian target of Rapamycin complex 1 (mTORC1) inhibitors
Mechanistic target of Rapamycin: integrating growth factor and nutrient signaling in the collecting duct
… Restriction Was Attenuated by Oxidative-Stress-Induced inhibition of Vacuolar H+-Adenosine Triphosphatase/Mechanistic Target of Rapamycin Complex 1 Signaling
Rapamycin and FK506 derivative TH2849 could ameliorate neurodegenerative diseases through autophagy with low immunosuppressive effect
… Apoptosis in the NCI-H1650 Non-Small Cell Lung Cancer Cell Line via inhibition of AKT/Mammalian Target of Rapamycin (mTOR)/Ribosomal Protein S6 …
Prevention of type 1 diabetes with acetalated dextran microparticles containing Rapamycin and pancreatic peptide P31
Rapamycin attenuates pathological hypertrophy caused by an absence of trabecular formation
Rapamycin prolongs graft survival and induces CD4+ IFN-γ+ IL-10+ regulatory type 1 cells in old recipient mice
Hollow Fe3O4/graphene oxide nanocomposites as novel Rapamycin carrier: formulation optimization and in vitro characterization
… GTPase-activating protein 1 regulates cytoskeletal reorganization and facilitates NKG2D-mediated mechanistic target of Rapamycin complex 1 activation and …
Production, characterization, and cross-reactivity of a polyclonal antibody against Arabidopsis TARGET OF Rapamycin
Differential effects of various genetic mouse models of the mechanistic target of Rapamycin complex I inhibition on heart failure
Different roles of Akt and mechanistic target of Rapamycin in serum‑dependent chondroprotection of human osteoarthritic chondrocytes
Glaucocalyxin A as a natural product increases amyloid β clearance and decreases tau phosphorylation involving the mammalian target of Rapamycin signaling …
in vitro determination of Rapamycin-triggered FKBP–FRB interactions using a molecular tension probe
… of the roles of phosphatidylinositol-4,5-bisphosphate and individual subunits in assembly, localization, and function of Saccharomyces cerevisiae target of Rapamycin …
Derivation of Rapamycin: adventures in natural product chemistry
Performance, diameter of muscle fibers, and gene expression of mechanistic target of Rapamycin in pectoralis major muscle of broilers supplemented with leucine and …
Biogenesis of Autophagosome in Trichomonas vaginalis during Macroautophagy Induced by Rapamycin‐treatment and Iron or Glucose Starvation Conditions
Regulation of protein kinase cδ nuclear import and Apoptosis by Mechanistic target of Rapamycin Complex-1
… and hydrodynamic injection and sequential stacking featuring sweeping for signal amplification following MEKC during the analysis of Rapamycin (sirolimus) in serum …
Restoring T-helper 17 cell/regulatory T-cell balance and decreasing disease activity by Rapamycin and all-trans retinoic acid in patients with systemic lupus …
Rapamycin and FTY720 alleviate atherosclerosis by cross talk of macrophage polarization and autophagy
CLOVES syndrome: treatment with oral Rapamycin. Report of two cases
Enhanced Rapamycin delivery to hemangiomas by lipid polymer nanoparticles coupled with anti-VEGFR antibody
Insulin-mimetic effects of short-term Rapamycin in type 1 diabetic patients prior to islet transplantation
Clinical monitoring challenges in the pharmacological treatment and management of lymphatic anomalies with mammalian target of Rapamycin inhibition
Rapamycin inhibits the growth and collagen production of fibroblasts derived from human urethral scar tissue
Osteopontin counters human immunodeficiency virus type 1–induced impairment of neurite growth through mammalian target of Rapamycin and beta-integrin …
… effects of hemp seed/evening primrose oil supplement in comparison with Rapamycin on the expression of the mammalian target of Rapamycin-complex 2 and …
Concomitant use of Rapamycin and rosiglitazone delays the progression of polycystic kidney disease in Han: SPRD rats: A study of the mechanism of action
Poly (ADP‐ribose) polymerase 1 induces cardiac fibrosis by mediating mammalian target of Rapamycin activity
Premature recruitment of oocyte pool and increased mTOR activity in Fmr1 knockout mice and reversal of phenotype with Rapamycin
A unified mitochondria mechanistic target of Rapamycin acyl‐coenzyme A dehydrogenase 10 signal relay modulation for metformin growth inhibition in human …
Epimagnolin targeting on an active pocket of mammalian target of Rapamycin suppressed cell transformation and colony growth of lung cancer cells
Single injection of Rapamycin blocks post–food restriction hyperphagia and body-weight regain in rats.
Hypertrophied myocardium is vulnerable to ischemia/reperfusion injury and refractory to Rapamycin-induced protection due to increased oxidative/nitrative stress
Effects of minocycline and Rapamycin in gamma-irradiated human embryonic stem cells-derived cerebral organoids
Hepatic phosphorylation status of serine/threonine kinase 1, mammalian target of Rapamycin signaling proteins, and growth rate in Holstein heifer calves in …
Overexpression of Biglycan is Associated with Resistance to Rapamycin in Human WERI-Rb-1 Retinoblastoma Cells by Inducing the Activation of the …
Effect of Rapamycin on the level of autophagy in rats with early heart failure
Protein kinase C is a key target for attenuation of Leigh syndrome by Rapamycin
Mammalian target of Rapamycin complex 1 activation disrupts the Low-Density lipoprotein receptor pathway: a novel mechanism for extracellular matrix accumulation …
… by lowering drug resistance through inhibition of far-upstream element-binding protein 2-mediated phosphoinositide 3-Kinase/Akt/mammalian target of Rapamycin …
Effects of inhibiting mTOR with Rapamycin on behavior, development, neuromuscular physiology and cardiac function in larval Drosophila
… promotes the proliferation and migration of human glioma cancer cells through the protein kinase B/mechanistic target of Rapamycin pathway by phosphatase …
Combining the mammalian target of Rapamycin inhibitor, Rapamycin, with resveratrol has a synergistic effect in multiple myeloma
… protects the myocardium in sepsis by activating the phosphatidylinositol 3-kinases (PI3K)/AKT/mammalian target of Rapamycin (mTOR) pathway and inhibiting …
Nanostructured lipid carriers containing Rapamycin for prevention of corneal fibroblasts proliferation and haze propagation after burn injuries: In vitro and in vivo
… of cell migration and invasion, and suppression of phosphatidylinositol 3-kinases (PI3K)/AKT/mammalian target of Rapamycin (mTOR) signaling pathway
… of economic evaluations of tyrosine kinase inhibitors of vascular endothelial growth factor receptors, mammalian target of Rapamycin inhibitors and programmed death …
Insulin-like growth factor 1 inhibits autophagy of human colorectal carcinoma drug-resistant cells via the protein kinase B/mammalian target of Rapamycin …
Simultaneous activation of impaired autophagy and the mammalian target of Rapamycin pathway in oral squamous cell carcinoma
Correction: Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of akt/mammalian target of Rapamycin pathway
Rapamycin enhances lytic replication of Epstein-Barr virus in gastric carcinoma cells by increasing the transcriptional activities of immediate-early lytic promoters
Mammalian target of Rapamycin complex 2 signaling in obese women changes after bariatric surgery
Activity dependent mammalian target of Rapamycin pathway and brain derived neurotrophic factor release is required for the rapid antidepressant effects of puerarin
Rapamycin protects against early brain injury independent of cerebral blood flow changes in a mouse model of subarachnoid haemorrhage
Expression of the miR-150 tumor suppressor is restored by and synergizes with Rapamycin in a human leukemia T-cell line
Locomotor treadmill training promotes soleus trophism by mammalian target of Rapamycin pathway in paraplegic rats
A Semi-Quantitative Drug Affinity Responsive Target Stability (DARTS) assay for studying Rapamycin/mTOR interaction
Discovery of the actinoplanic acid pathway in Streptomyces Rapamycinicus reveals a genetically conserved synergism with Rapamycin
Molecular interplay between hyperactive mammalian target of Rapamycin signaling and Alzheimer’s disease neuropathology in the NS-Pten knockout mouse model
… against advanced renal cell carcinoma by dual targeting of Akt/pyruvate kinase muscle isozyme M2 and mechanistic target of Rapamycin complex 1 pathways
The putative transcription factor CaMaf1 controls the sensitivity to lithium and Rapamycin and represses RNA polymerase III transcription in Candida albicans
Myeloid-derived suppressor cells (MDSCs) and mechanistic target of Rapamycin (mTOR) signaling pathway interact through inducible nitric oxide synthase …
Rapamycin exposure to host and to adult worms affects life history traits of Heligmosomoides bakeri
Rapamycin‑induced autophagy attenuates hormone‑imbalance‑induced chronic non‑bacterial prostatitis in rats via the inhibition of NLRP3 inflammasome …
Genetic defects in SAPK signalling, chromatin regulation, vesicle transport and CoA-related lipid metabolism are rescued by Rapamycin in fission yeast
Effects and Mechanisms of Rapamycin Action on Experimental Neurodegeneration
Mechanistic target of Rapamycin (mTOR) implicated in plasticity of the reproductive axis during social status transitions
… attenuates airway inflammation by suppressing autophagy via phosphatidylinositol 3‐kinase/protein kinase B/mammalian target of Rapamycin signaling pathway in rat …
CLAPO syndrome: Effective response to treatment with oral Rapamycin
Ketamine effects on mammalian target of Rapamycin signaling in the mouse limbic system depend on functional dopamine D3 receptors
Novel function of cyclooxygenase-2: suppressing mycobacteria by promoting autophagy via the protein kinase B/mammalian target of Rapamycin pathway
… Epithelial-to-Mesenchymal Transition (EMT) progression and Adenosine Monophosphate Activated Protein Kinase (AMPK)/Mammalian Target of Rapamycin …
… proliferation of human ovarian cancer cells in vitro via the phosphatidylinositol-3-kinase (PI3K)/akt and the mammalian target of Rapamycin (mTOR) and Wnt/β …
Role of mammalian target of Rapamycin signaling pathway in regulation of fatty acid oxidation in a preeclampsia-like mouse model treated with pravastatin
Long-Term Exposure and Safety of a Novel Topical Rapamycin Cream for the Treatment of Facial Angiofibromas in Tuberous Sclerosis Complex: Results From a …
PPP2R2D, a regulatory subunit of protein phosphatase 2A, promotes gastric cancer growth and metastasis via mechanistic target of Rapamycin activation
Interferon regulatory factor 1 eliminates mycobacteria by suppressing p70 S6 kinase via mechanistic target of Rapamycin signaling
Rapamycin reduces mortality in acute-stage paraquat-induced toxicity in zebrafish
Cloning and characterization of the target protein subunit lst8 of Rapamycin in Apostichopus japonicus
Target of Rapamycin FATC domain as a general membrane anchor: The FKBP‐12 like domain of FKBP38 as a case study
Stable isotope labeling reveals novel insights into ubiquitin-mediated protein aggregation with age, calorie restriction, and Rapamycin treatment
The correlation between mammalian target of Rapamycin (mTOR) gene expression and sperm DNA damage among infertile patients with and without varicocele
CC-115, a Dual mammalian target of Rapamycin/DNA-dependent protein kinase inhibitor in clinical trial, is a substrate of ATP-binding cassette G2, a risk factOR for …
Facial angiofibromas treated by Rapamycin 0.05% ointment and a combined laser therapy
… are mediated via mitochondrial-mediated apoptosis, inhibition of cell migration, invasion suppression, and mammalian target of Rapamycin (mTOR)-TOR/PI3K …
The Continuous Story of the Miraculous Drug, Rapamycin
… lysine/methionine ratios and glucose levels and their effects on casein synthesis via activation of the mechanistic target of Rapamycin signaling pathway in …
The combination of NVP‑BEZ235 and Rapamycin regulates nasopharyngeal carcinoma cell viability and apoptosis via the PI3K/AKT/mTOR pathway
CD8+ T cells: mechanistic target of Rapamycin and eukaryotic initiation factor 2 in elite HIV-1 control
Rapamycin blocks the neuroprotective effects of sex steroids in the adult birdsong system
Orexin-A Stimulates Insulin Secretion Through the Activation of the OX1 Receptor and Mammalian Target of Rapamycin in Rat Insulinoma Cells
Rapamycin but not acarbose decreases age-related loss of outer hair cells in the mouse Cochlea
Sepsis-induced myocardial dysfunction and mammalian target of Rapamycin signalling pathways
Rapamycin induces an eNOS dependent increase in brain collateral perfusion after acute experimental stroke in rats
Polycystin-2 is required for starvation-and Rapamycin-induced atrophy in myotubes
Current Update on Rapamycin Production and its Potential Clinical Implications
The effects of AICAR and Rapamycin on mitochondrial function in immortalized mitochondrial DNA mutator murine embryonic fibroblasts
Tivantinib hampers the proliferation of glioblastoma cells via PI3K/Akt/Mammalian Target of Rapamycin (mTOR) signaling
… lignocaine exhibits potent antilung cancer cell activity by inhibiting the phosphoinositide 3-kinases/mammalian target of Rapamycin/mammalian target of Rapamycin …
Systemic Rapamycin Attenuates Morphine-Induced Analgesic Tolerance and Hyperalgesia in Mice
Integrating microRNA and mRNA expression in Rapamycin-treated T-cell acute lymphoblastic leukemia
Gastric Mammalian Target of Rapamycin Signaling Contributes to inhibition of Ghrelin Expression Induced by Roux-En-Y Gastric Bypass
Neuroprotective effect of Rapamycin against Parkinson’s disease in mice
Second-line treatment after sunitinib therapy in patients with renal cell carcinoma: a comparison of axitinib and mammalian target of Rapamycin inhibitors
Effects of Rapamycin in combination with fludarabine on primary chronic lymphocytic leukemia cells
Rapamycin affect the apoptosis of splenic CD4+ CD25+ regulatory T cells of mouse severe aplastic anemia model
Role of mammalian target of Rapamycin activation in menthol-induced expressions of airway inflammation-related factors in human bronchial epithelial cells in vitro
Local intra-articular injection of Rapamycin inhibits NLRP3 activity and prevents osteoarthritis in mouse DMM models
Rapamycin increases breast tumor burden in young wheel-running mice
Decreased Expression of Urinary Mammalian Target of Rapamycin mRNA Is Related to Chronic Renal Fibrosis in IgAN
Rapamycin induces the expression of heme oxygenase-1 and peroxyredoxin-1 in normal hepatocytes but not in tumorigenic liver cells
Activation of mammalian terget of Rapamycin kinase and glycogen synthase kinase‐3β accompanies abnormal accumulation of cholesterol in fibroblasts from …
… expression of muscle RING‐finger protein‐1 and muscle atrophy F‐box proteins and proteins involved in the mechanistic target of Rapamycin pathway and autophagy …
Rapamycin protects against paraquat‑induced pulmonary epithelial‑mesenchymal transition via the Wnt/β‑catenin signaling pathway
… (mRCC) treated with vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKI) and mammalian target of Rapamycin inhibitors (mTORI) after …
Rapamycin administration during normal and diabetic pregnancy effects the mTOR and angiogenesis signaling in the rat placenta
… neointima hyperplasia after vascular injury via p-adenosine 5′-monophosphate-activated protein kinase/mammalian target of Rapamycin complex 1 pathway
inhibition of mammalian target of Rapamycin decreases intrarenal oxygen availability and alters glomerular permeability
Chromosomal Instability and Evolution of Transformed Phenotype in Cell Lines Selected from Senescent Rat Embryonic Fibroblasts with Rapamycin
Renal Cell Carcinoma Associated With Xp11. 2 Translocation/TFE3 Gene-fusion: A Long Response to mammalian target of Rapamycin (mTOR) Inhibitors
A combination regimen of low-dose bortezomib and Rapamycin prolonged the graft survival in a murine allogeneic islet transplantation model
Synthesis and anticancer activity of novel Rapamycin C‐28 containing triazole moiety compounds
Correction to: The mTOR inhibitor Rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells
Co-localization of insulin-like growth factor binding protein-1, casein kinase-2β, and mechanistic target of Rapamycin in human hepatocellular carcinoma cells …
Oral Preconditioning of Donors After Brain Death With Calcineurin Inhibitors vs. Inhibitors of Mammalian Target for Rapamycin in Pig Kidney Transplantation.
Efficacy and Safety of Mammalian Target of Rapamycin Inhibitor Use—Long-term Follow-up of First Tuberous Sclerosis Complex Patient Treated De Novo With …
Cysteine‐rich protein 61 regulates adipocyte differentiation from mesenchymal stem cells through mammalian target of Rapamycin complex 1 and canonical Wnt …
Retrospective study of Rapamycin or rapalog 0· 1% cream for facial angiofibromas in tuberous sclerosis complex: evaluation of treatment effectiveness and cost
… Flux in Human Bone Mesenchymal Stromal Cells via NMDA Receptor–Ca2+–Extracellular Signal-Regulated Kinase–Mammalian Target of Rapamycin …
Variability of the mammalian target of Rapamycin inhibitors is correlated with long-term renal graft survival
inhibition of 5‐Hydroxytryptamine Receptor 2B Reduced Vascular Restenosis and Mitigated the β‐Arrestin2–Mammalian Target of Rapamycin/p70S6K Pathway
Assessing the mechanistic target of Rapamycin complex-1 pathway in response to resistance exercise and feeding in human skeletal muscle by multiplex assay
Rapamycin Rescues Age-Related Changes in Muscle-Derived Stem/Progenitor Cells from Progeroid Mice
A Photo‐Stable Indocyanine Green and Rapamycin Co‐Delivery System Based on Poly (Glutamic Acid)‐Modified Manganese Phosphate for Synergetic Tumor …
Early Switch to Mammalian Target of Rapamycin Inhibitors Is a Sustainable Treatment Approach in Renal Transplant Recipients: 7-Year Results
Captopril suppresses hepatic mammalian target of Rapamycin cell signaling and biomarkers of inflammation and oxidative stress in thioacetamide-induced …
Rapamycin-induced Protein Dimerization as a Tool for C. elegans research
… and inflammatory response by Rapamycin in target and distant organs in rats exposed to hindlimb ischemia–reperfusion: the role of mammalian target of Rapamycin
FRI0063 Rapamycin induces remission in patients with refractory rheumatoid arthritis
Laser-Assisted Delivery of Topical Rapamycin: mTOR inhibition for Birt–Hogg–Dube Syndrome
Influence of phosphatidylinositol-3-kinase/protein kinase b-mammalian target of Rapamycin signaling pathway on the neuropathic pain complicated by …
Rapamycin and ZSTK474 can have differential effects at different post‑infection time‑points regarding CVB3 replication and CVB3‑induced autophagy
… in vitro and in mouse tumor xenografts and activates autophagy and apoptosis by downregulation of the mammalian target of Rapamycin (mTOR)/PI3K/AKT …
AB0536 Rapamycin attenuates symptom and restores the balance of th17/treg in refractory primary sjogren’s syndrome
Suren Sehgal & The Story of Rapamycin
Molecular Mechanisms in Signaling by Target of Rapamycin Complex 2 in Saccharomyces cerevisiae
Analysis of the inhibitory effect of Rapamycin on Fusarium asiaticum by next generation RNA sequencing
Bioinformatics analysis of gefitinib or Rapamycin on inhibiting the survival of hela in the low glucose and high lactic acid environment
Semisynthesis of 3‐Hydroxyoxindole Rapamycin Analogues Through Site‐ and Stereoselective Trapping of Oxonium Ylides in RhII‐Catalyzed Three‐Component …
Rapamycin alleviated pulmonary injury induced by fat embolism syndrome in rats
AB0376 Rapamycin induces remission in patients with newly diagnosed rheumatoid arthritis
Effect of mechanistic target of Rapamycin inhibitors on postrenal transplantation malignancy: A nationwide cohort study
Central action of Rapamycin on early ischemic injury and related cardiac depression following experimental subarachnoid hemorrhage
… electromagnetic fields inhibit osteoclast differentiation in RAW264. 7 macrophages via suppression of the protein kinase B/mammalian target of Rapamycin …
Assessing the efficacy of mammalian target of Rapamycin inhibitors by phosphorylation of p70S6K in CD4-positive cells of liver transplant patients
CK2 Inhibitor CX4945 Shows Strong In Vivo Synergistic Anti-Leukemia Activity with Rapamycin in B-ALL Due to Enhanced Ikaros Mediated Repression of mTOR …
The role of mammalian target of Rapamycin pathway in the pathogenesis of pauci-immune glomerulonephritis
Response to Mammalian Target of Rapamycin–Based Therapy and Incidental Finding of Lynch Syndrome in a Patient With Solid Pseudopapillary Neoplasm …
Redox-proteomes of human NOS1-transduced versus MOCK SH-SY5Y neuroblastoma cells under full nutrition, serum-free starvation, and Rapamycin …
Activation of mammalian target of Rapamycin induces lipid accumulation in the diaphragm of ventilated rats and hypoxia-treated C2C12 cells
Reversible Suppression of Lymphoproliferation and Thrombocytopenia with Rapamycin in a Patient with Common Variable Immunodeficiency
Construction of a mutant of Actinoplanes sp. N902-109 that produces a new Rapamycin analog
The protective effect and mechanism of Rapamycin in the rat model of IgA nephropathy
Silent information regulator 1 negatively regulates atherosclerotic angiogenesis via mammalian target of Rapamycin complex 1 signaling pathway
Rapamycin in the treatment of renal diseases associated with tuberous sclerosis complex
P. 255Possible efficacy of Rapamycin on myodegeneration in VCPDM mouse model
A NOVEL APPROACH IN COLORECTAL CANCER AND DIABETES MANAGEMENT: ROLE OF METFORMIN AND Rapamycin
B-cell-specific mammalian target of Rapamycin complex 1 activation results in severe osteoarthritis in mice
A novel diazoresin/Rapamycin covalent capillary coating for the separation of biomacromolecules by capillary electrophoresis
Role of LncRNA MALAT-1 and MicroRNA-199 in Rapamycin induced cardioprotection against reperfusion injury in diabetic rabbits
Treatment of benign cephalic histiocytosis with topical 1% Rapamycin ointment
inhibition of Nasopharyngeal Carcinoma by Beta-Lapachone Occurs by Targeting the Mammalian Target of Rapamycin (mTOR)/PI3K/AKT Pathway, Reactive …
Does mammalian target of Rapamycin or sestrin 1 protein signaling have a role in bone fracture healing?
Deregulated phospholipase D2/mammalian target of Rapamycin/hypoxia-inducible factor 1 alpha in peripheral T lymphocytes of oral lichen planus correlated with …
Synergistic cytoprotection by co-treatment with dexamethasone and Rapamycin against proinflammatory cytokine-induced alveolar epithelial cell injury
Evidence that decreased expression of sinusoidal bile acid transporters accounts for the inhibition by Rapamycin of bile flow recovery following liver ischemia
SP772 Rapamycin PROMOTES CELLULAR DEATH THROUGH THE ACTIVATION OF AUTOPHAGY VIA P75NTR IN KAPOSI SARCOMA CELLS
Rapamycin Suppresses TGF-β1-Induced Nasopharyngeal Cancer Stem Cell Metastasis by Inhibiting Mitochondrial Metabolism
Research advances in the mammalian target of Rapamycin signaling pathway and its inhibitors in treatment of hepatocellular carcinoma
The impact of mammalian target of Rapamycin inhibition on bone health in postmenopausal women with hormone receptor-positive advanced breast cancer …
Mammalian target of Rapamycin inhibitors in a patient with polycystic kidney disease-1-tuberous sclerosis-2 contiguous gene syndrome
siRNA blocking of mammalian target of Rapamycin (mTOR) attenuates pathology in annonacin-induced tauopathy in mice
Effect of Rapamycin on mesenchymal stem cells treatment for swine myocardial infarction
Amino Acid-and Insulin-Induced Activation of Mechanistic Target of Rapamycin Complex 1 in Neonatal Piglet Skeletal Muscle Involves Sestin2-GATOR2, Rag A/C …
Enhanced Production of Anti-PD1 Antibody in CHO Cells through Transient Co-Transfection with Anti-Apoptotic Gene Bcl-xL Combined with Rapamycin
Metformin: Antineoplastic Activity through the Mammalian Target of Rapamycin Pathway
4-Phenylbutyric acid and Rapamycin improved diabetic status in high fat diet/streptozotocin-induced type 2 diabetes through activation of autophagy
… Papillomavirus of High Oncogenic Potential in Immunosuppressed Women on Renal Replacement Therapy With and Without Mammalian Target of Rapamycin …
The Mammalian Target of Rapamycin–70-kDa Ribosomal Protein S6 Kinase Axis Inhibits the Biological Function of Tongue Squamous Cell Carcinoma
Assessment of drug–drug interaction potential and PBPK modeling of CC-223, a potent inhibitor of the mammalian target of Rapamycin kinase
Regression of renal angiomyolipomas with oral Rapamycin therapy in a patient with tuberous sclerosis complex disease
Combined treatment with simvastatin and Rapamycin attenuates cardiac allograft rejection through the regulation of T helper 17 and regulatory T cells
Differential expression of phospho‐S6 in hair follicle tumors: Evidence of mammalian target of Rapamycin pathway activation
Impact of Rapamycin on Genome Organization
Srategies for enhanced production of Rapamycin
Targeting Cancer cell metabolism via Target of Rapamycin
INTERVENTION WITH Rapamycin TO IMPROVE HEALTHY AGING AND LONGEVITY IN A NON-HUMAN PRIMATE
Kaposi Sarcoma in the Era of Rapamycin Remains a Therapeutic Challenge in Organ Transplant Recipients.
Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin
The mammalian target of Rapamycin protein expression in human granulosa cell tumors
Effects of Rapamycin on chromatin–implications for ageing and tumour suppression
Mammalian Target of Rapamycin Inhibitors and Survival in Heart Transplant Recipients: Miracle or Mirage?
Reply: Mammalian Target of Rapamycin Inhibitors and Survival in Heart Transplant Recipients: Miracle or Mirage?
Differential Roles of Mammalian Target of Rapamycin Complexes 1 and 2 in Migration of Prostate Cancer Cells
Mitigation of Inflammation Induced By Monosodium Urate Crystals in Mice By Treatment with SVP-Rapamycin
Arterial infusion of Rapamycin in the treatment of rabbit hepatocellular carcinoma to improve the effect of TACE
… 2 Clinical Data of SEL-212 in Symptomatic Gout Patients: Monthly Dosing of a Pegylated Uricase (Pegadricase) with Svp-Rapamycin Enables Sustained Reduction of …
Treatment with Rapamycin or Rapamycin in combination with metformin contributes to mechanisms of mitochondrial proteostasis in vivo and in vitro
GW29-e1749 Delayed reendothelialization with Rapamycin is rescued by the addition of nicorandil in balloon-injured rat carotid arteries
The effects of Rapamycin on the symptoms of cerebral ischemia due to changing the expression of miR-1 and its target genes, Bad and Bcl-w
Correction: Rapamycin Is Neuroprotective in a Rat Chronic Hypertensive Glaucoma Model
Successful transcatheter aortic valve replacement in a kidney allograft patient on Rapamycin
Pre-treatment with Rapamycin protects hematopoiesis against radiation injury
Role of Mammalian Target of Rapamycin in Muscle Growth
Anti-scarring effect of Rapamycin in rabbits following glaucoma filtering surgery
Target Of Rapamycin pathway in the white-rot fungus Phanerochaete chrysosporium
Synergy of Rapamycin and Cyanoacrylate in Reducing Intimal Hyperplasia
067 Rapamycin Suppresses NADPH Oxidase-mediated Reactive Oxygen Species Production and Reverses Erectile Dysfunction in Western Diet-fed Mice
Viability, Growth and Reproduction of Heligmosomoides bakeri During a Secondary Infection of a Host Treated with Rapamycin
Use of Topical Rapamycin as Maintenance Treatment after a Single Session of Fractionated CO 2 Laser Ablation: A Method to Enhance Percutaneous Drug …
Discovery of potential mammalian target of Rapamycin inhibitors: A combination of virtual screening and molecular docking studies.
Mathematical modelling of mammalian target of Rapamycin following leucine ingestion
Wound Repair and the Immune System in the Presence of Rapamycin
SAT0280 Rapamycin restores the balance between th17 and regulatory t cells in uspa patients
Synergistic antifibrotic effect of Rapamycin and Zoledronic acid in advanced murine biliary fibrosis
Production of interleukin-1β related to mammalian target of Rapamycin/Toll-like receptor 4 signaling pathway during Aspergillus fumigatus infection of the …
AB0382 Rapamycin selectively increases circulating tregcellsand maintain remission of patients with rheumatoid arthritis
Local release of Rapamycin by microparticles delays islet rejection within the anterior chamber of the eye
Regarding “Rapamycin prevents thoracic aortic aneurysm and dissection in mice”
Rapamycin Promote the inhibition Rate of Proliferation on SHI-1 Cells and Enhance the Efficacy of Chemotherapy in Npg Leukemia Mice
ANTI-CELL SENESCENT EFFECTS OF Rapamycin AND THEIR ROLE IN DISEASES, INCLUDING ALZHEIMER’S
Different expression patterns of exosomal miRNAs under Cyclosporin A and Rapamycin treatment in distinct aggressiveness colorectal carcinomas
Targeting Delivery of Rapamycin With Anti-Collagen IV Peptide Conjugated Fe₃O₄@ Nanogels System for Vascular Restenosis Therapy
Rapamycin alleviates inflammation by up-regulating TGF-β/Smad signaling in a mouse model of autoimmune encephalomyelitis
Intranasal Rapamycin protects against cognitive decline in a mouse model of Down syndrome
Farnesyltransferase inhibitor and Rapamycin correct aberrant genome organisation and decrease DNA damage respectively, in Hutchinson–Gilford progeria syndrome …
Evaluation of the Effects of Nicotine on Mammalian Target of Rapamycin Complex 2 and Signal Transducer and Activator of Transcription 3 Genes Expression in a …
Efficacy of brain-targeted Rapamycin for treatment of epilepsy in rats
AN EXPERIMENTAL RESEARCH OF THE EFFECTS OF Rapamycin ON THE IN VITRO PROLIFERATION AND GROWTH OF TREGS IN MICE BY …
Rapamycin-Based Expansion of Natural CD8+ Tregs for Cell Therapy
Metabolic regulation of insulin secretion: the link between excess glucose, mechanistic target of Rapamycin complex 1 & hyperinsulinemia
Autophagy in Hepatocellular Carcinoma-29 after Single or Combined Administration of Lithium Carbonate and Rapamycin
Belatacept and Rapamycin with Short-Term Use of Tacrolimus Delay Allograft Rejection in a Novel, Large Animal Vascularized Composite Allotransplantation Model
The Effect of Acute Aerobic Exercise and Rapamycin Treatment on Autophagy and the Heat Shock Response in Peripheral Blood Mononuclear Cells of Prediabetics
A Randomized Trial of Rapamycin to Increase Longevity and Healthspan in Companion Animals: Navigating the Boundary Between Protections for Animal Research …
Use of TGF-beta plus Rapamycin to Induce Foxp3, promote iTreg Development and Suppressive Function, and Induce Long-Term Allograft Survival
Rapamycin decreases presenilin-1 in SK-N-SH cells
Deep proteome of human nNOS/NOS1-positive versus MOCK SH-SY5Y neuroblastoma cells under full nutrition, serum free starvation and Rapamycin …
Immunohistochemical study of folate receptor-α and mammalian target of Rapamycin in endometrial hyperplasia and endometrioid endometrial carcinoma
Advance of Mechanisms and Clinical Applications about Rapamycin for Treating Immune Mediated Hemocytopenia–Review
Mammalian target of Rapamycin inhibitor and transarterial embolization for treatment of tuberous sclerosis complex patients with renal angiomyolipoma
P126/O29 mTOR blockade by Rapamycin decreases arthritis and spondylitis development and severity in HLA-B27 transgenic rats
Efficacy and Safety of Early Mammalian Target of Rapamycin Inhibitors with Minimization of Calcineurin Inhibitors in Kidney Transplant Recipients
… kinase (CHK1) inhibitor, and LY3023414, a dual inhibitor of class I phosphatidylinositol 3-kinase (PI3K) and the mammalian target of Rapamycin (mTOR) in patients …
New Use of Rapamycin Stent in Non-Responding Facial Lymphatic Malformation
Roles of Mammalian Target of Rapamycin Signaling and Autophagy Pathway in Alzheimer’s Disease
Erratum: Rapamycin-induced protein dimerization as a tool for C. elegans research. microPublication Biology
FRI0150 mTOR blockade by Rapamycin decreases arthritis and spondylitis development and severity in hla-b27 transgenic rats
Lung Function Response and Changes of Lung Cysts to Rapamycin for Lymphangioleiomyomatosis: Long-Term Follow-Up Observational Study
Rapamycin Induces Apoptosis of K562 Cells through EZH2/Hedgehog Signaling Pathway
Rapamycin prevents surgery-induced T cell exhaustion in patients with bladder cancer
Safety and Effectiveness of FlexyRap® Cobalt-Chromium Rapamycin-Eluting Stents with Biodegradable Polymer in Coronary Artery Disease: Results from a 2 …
Clinical importance of microtubule-associated protein 1 light chain 3 and mammalian target of Rapamycin expression in oral leukoplakia and oral squamous cell …
Evaluation of the interaction between melatonin and Rapamycin for head and neck cancer therapy
A new mTOR-independent effect of Rapamycin: Transcriptional regulation of TRIB3
INTERACTION OF ALPHA SYNUCLEIN WITH TARGET OF Rapamycin (TOR): A REVIEW
Evaluation of the Effects of Nicotine on Mammalian Target of Rapamycin Complex 2 and Signal Transducer and Activator of Transcription 3 Genes Expression in a …
Mammalian target of Rapamycin: biological functions and mechanisms.
Rapamycin attenuates Th2-driven experimental allergic conjunctivitis
Rapamycin partially rescues oocyte dysfunction in mice deficient for mitochondrial stress response protein CLPP
Impaired follicular development and ovulation in PCOS mouse model can rescued by Rapamycin treatment
The activity of S. pombe LTR retrotransposons is activated in response to Rapamycin
Combination of Rapamycin with immune checkpoint blockade in a syngeneic breast carcinoma model
Combination of Rapamycin and Resveratrol for Treatment of Bladder Cancer.
Overexpression of regulatory gene rapG enhances the yield of Rapamycin.
THU0098 Combination therapy of Rapamycin and a glutamine antagonist facilitates the expansion of myeloid-derived suppressor cells and ameliorates arthritis in skg …
Toward Novel Therapeutics for TSC and LAM: Using Mechanisms of a Bacterial Protein to Sensitize Cells to Rapamycin
Neuroprotective Effects of the Small-Molecule Enhancer of Rapamycin in the Cellular Model of Parkinson’s Disease
Rapamycin treatment starting at 24 h after cerebral ischemia/reperfusion exhibits protective effect on brain injury in rats
Resistance Reversion of Rapamycin on Ovarian Cancer Cell Line SKOV3/DDP and Its Molecular Mechanisms
Discovery of Novel Leucyl-tRNA Synthetase (LRS)-Targeted Mammalian Target of Rapamycin Complex 1 (mTORC1) Inhibitors
The mammalian target of Rapamycin complex 1 (mTORC1) and the regulation of opioid efficacy
Consensus Statement: sirolimus (Rapamycin) as therapy for lymphangioleiomyomatosis (2018)
Evaluation of the Effects of Nicotine on Mammalian Target of Rapamycin Complex 2 and Signal Transducer and Activator of Transcription 3 Genes Expression …
Expression of autophagy level in the aorta of diabetic rats and the intervention effect of Rapamycin
Sugar and spice in epilepsy: Modulation of epilepsy and epileptogenesis by Rapamycin and curcumin in experimental models of temporal lobe epilepsy
Retracted: Rapamycin prevents apoptosis of myocardial cells in heart failure rats through up-regulating Akt
Effect of Rapamycin on gene expression of nuclear factor-? B p65 and STAT-1 in sprague-dawley rats with acute lung injury
Expression and Clinical Significance of Late Endosomal/Lysosomal Adaptor, Mitogen-activated Protein Kinase and Mammalian Target of Rapamycin Activator 3 in …
Autophagy and Expression of UCH-L3 Induced by Rapamycin in HL-60 Cells
MON-LB054 Activity of Prolactin Receptor Antagonist-Rapamycin Conjugate in Glioblastoma Multiform
siRNA Blocking of Mammalian Target of Rapamycin (mTOR) Attenuates Toxicity in Annonacin Induced Tauopathy in Mice
Effect of Rapamycin on expression of Caspase-9 and Ki-67 in neuroendocrine tumor tissues
IGF2 as a Potential Novel Therapeutic Target for Rapamycin-Insensitive LAM Patients
TCT-624 A prospective multicenter randomized post-market trial evaluating a novel Cobalt Chrome Rapamycin Drug Eluting Stent: Subgroup Analysis of the TARGET …
Rapamycin suppresses T cell responses in recoverin-induced autoimmune retinopathy and prevents disease progression in the eyes
Rapamycin-eluting stents for unprotected left main coronary artery stenosis in older adult patients with coronary atherosclerosis: study protocol for a …
Rapamycin Treatment Promotes Myofibril Relaxation Kinetics and Reduces Myocardial Stiffness to Improve Diastolic Function in Old Murine Hearts
Disruption of Mammalian Target of Rapamycin Complex 1 in Myeloid cells Promotes Lung Cancer Metastasis
Abstract# 3183 Treatment with Rapamycin affects behavioral and brain protein expression in rats with experimentally induced glioblastoma
Effect of Rapamycin on the biological behaviors of human non-Hodgkin lymphoma Raji cells and its mechanism
Immunohistochemical evaluation of p-mTOR (Phosphorylated Mammalian Target of Rapamycin) in oral squamous cell carcinoma
Rapamycin-induced autophagy of Ana-1 cells play the lethality to melanized Penicillium marneffei
THE EFFECTS OF 4 WEEKS HIGH INTENSITY INTERVAL TRAINING ON MAMMALIAN Rapamycin TARGET PROTEIN (mTOR) AND STEROL TRANSCRIPTION …
Rapamycin Protects Against Paraquat-induced Pulmonary Epithelial Mesenchymal Transition through Wnt/β-catenin Pathway
Rapamycin promotes trans-differentiation while inhibiting mTOR activity in glioblastoma cells
Efficacy of self-made Gengnian decoction on phosphatidylinositol 3-kinases/protein kinase B/mammalian target of Rapamycin signaling pathway in perimenopausal …
TREATMENT OF BETA-THALASSEMIA PATIENTS WITH Rapamycin (SIROLIMUS): FROM PRE-CLINICAL RESERCH TO A CLINICAL TRIAL
Cuprizone model of demyelination in the presence of mTOR inhibitor Rapamycin
BD-02 Blockade of the mechanistic target of Rapamycin elicits rapid and lasting improvement of disease activity through restraining pro-inflammatory T cell …
Rapamycin protects human lens epithelial cells against oxidative stress induced by high glucose
IGF-Ⅱrestores Rapamycin-induced suppression of β-cell differentiation and expansion of adult pancreas stem cells
Roles of Mechanistic Target of Rapamycin Complexes in Retinal Development and Visual Function
Investigation of Functionally Important Residues in Histone Variant H2A. Z and the Effect of Rapamycin on Saccharomyces Cerevisiae
Mechanistic target of Rapamycin enhances fibrosis in lung by promoting epithelial mesenchymal transition
MP38-06 Rapamycin REGULATION OF CORE CLOCK GENES IS ASSOCIATED WITH ALTERED DE-OBSTRUCTION SIGNATURES COORDINATE WITH …
Case Report: Surgical trauma induces overgrowth in lower limb gigantism: regulation with use of Rapamycin is promising
Delivery of Rapamycin-enriched Nanoparticles to Atherosclerotic Plaques Provides Targeted Regulation of the Macrophage mTORc1-autophagy Signaling Axis
PD-L1 as a Notential Therapeutic Target for Patients with Advanced or Refractory-to-Rapamycin Pulmonary Lymphangioleiomyomatosis (LAM)
The Mammalian Target of Rapamycin (mTOR)/Peroxisome Proliferator-Activated Receptor γ (PPARγ) axis drives immune dysfunction and outcome after burn injury.
Regulation of central carbon and nitrogen metabolism by Target of Rapamycin (TOR) kinase in Chlamydomonas reinhardtii
Effects of Rapamycin and mammalian target of Rapamycin-small interfering RNA (mTOR siRNA) on proli-feration, apoptosis and extracellular matrix in premature rats …
Original Investigation The mammalian target of Rapamycin protein expression in human granulosa cell tumors Güralp et al. mTOR protein expression in …
Effect of Rapamycin on the expression of autophagy-related proteins Unc-51 like autophagy activating kinase 1 and microtubule-associated protein 1 light chain 3 in …
Rapamycin protect puromycin amino nucleoside induced podocyte injury by up-regulating autophagy
Rapamycin Alters MicroRNA Signature Profile in Diabetic Rabbit following Myocardial Ischemia Reperfusion Injury: A Preclinical Approach for Cardioprotection.
Effects of postruminal amino acid supplementation on protein deposition and the mammalian target of Rapamycin signaling pathway in growing steers
Elastin-like polypeptide mediate subcutaneous delivery of Rapamycin in a murine model of Sjögren’s Syndrome
Rapamycin and Zoledronic Acid strongly retard growth of advanced murine hepatocellular carcinoma via skewing and activation of innate and adaptive immunity
Rapamycin-eluting stents for unprotected left main coronary artery stenosis in coronary atherosclerosis in the older adults: study protocol for a prospective, non …
Rapamycin and Zoledronic acid exert a potent antifibrotic effect in murine biliary fibrosis
Proteomics study of Rapamycin-injured human coronary artery endothelial cells based on two dimension fluorescence differential gel electrophoresis
Rapamycin promotes the survival and angiogenesis of high glucose-exposed human umbilical vein endothelial cells by improving autophagy
Rapamycin Can Ameliorate Antiretroviral Drug Mediated Cardiotoxicity
Correction to: Mammalian Target of Rapamycin 2 (mTOR2) and C-MYC Modulate Glucosamine-6-Phosphate Synthesis in Glioblastoma (GBM) Cells Through …
Rapamycin Treatment Reduces Myocardial Stiffness and Promotes Cardiomyocyte Relaxation to Restore Diastolic Function in Old Murine Hearts
Dissecting Rapamycin resistance in a Tsc2-null rat leiomyoma cell line developed in a murine xenograft
The role of mechanistic target of Rapamycin complex 2-component RICTOR in hepatocellular carcinoma progression and sorafenib-resistance
Tuberin S1365 Phosphorylation Regulates Mechanistic Target of Rapamycin Complex 1 (mTORC1) Pathological Signaling While Sustaining Metabolic Sensor …
Discovery and evaluation of WX047, a potent and oral active phosphoinositide 3-kinase (PI3K)/mammalian target of Rapamycin (mTOR) dual inhibitor
FDG-PET of mouse breast cancers on ketogenic vs. standard chow diets, with or without added Rapamycin.
Rapamycin enhanced autophagy favors tolerance induction in allotransplantation model through mTORC1/ULK1 pathway
Collecting‐duct‐principal‐cell‐select knockout (KO) of the mechanistic‐target‐of‐Rapamycin (mTOR) alters sodium and acid/base homeostasis
The Mammalian Target of Rapamycin Regulates Platelet Integrin Activation, Aggregation, and Ischemic Stroke
Mammalian Target of Rapamycin (mTOR) Inhibitor Induced Pulmonary Alveolar Proteinosis
Rapamycin affect the apoptosis of splenic CD4~+ CD25~+ regulatory T cells of mouse severe aplastic anemia model
Safety and efficacy of conversion from calcineurin inhibitors to mammalian-target-of-Rapamycin inhibitors in liver transplant recipients: a meta-analysis of randomized …
Promoter hypermethylation of Mammalian Target of Rapamycin Gene in Multiple Myeloma cells induced by curcumin
Rapamycin Protects Against Myocardial Ischemia/Reperfusion Injury in Diabetic Mice Through Stat3-mir17/92 Signaling and Suppression of Prolyl Hydroxylase
Rapamycin upregulates autophagy by inhibiting mTOR/P70S6K/4EBP1 signaling and reducing podocyte apoptosis
The Mechanistic Target of Rapamycin (mTOR) and Its Complex 1 Associated Protein RPTOR are Germ Cell-autonomously Required for Spermatogonial Development …
Mammalian target of Rapamycin (mTOR) and autophagy in hepatitis c virus-related hepatocellular carcinoma: relation to tumor progression
Targeting the phosphatidylinositol 3-kinase/Akt/mechanistic target of Rapamycin (PI3K/Akt/mTOR) signaling pathway in B-lineage acute lymphoblastic leukemia
… , Sirtuin1 and peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1alpha, overactive mammalian target of Rapamycin, and dysregulated metabolites …
MicroRNA-25 Modulates Proliferative Signaling Via the Mammalian Target of Rapamycin Pathway in Asthmatic Airway Smooth Muscle Cells In Vitro
D-1: The TOR (Target of Rapamycin) pathway governs growth and stress response in C. neoformans
The level of microRNA 21 is upregulated by Rapamycin in serum of tuberous sclerosis complex patients and subependymal giant cell astrocytoma (SEGA) …
… : Microtubule-associated protein/microtubule affinity-regulating kinase 4 (MARK4) is a negative regulator of the mammalian target of Rapamycin complex 1 (mTORC1).
Abstract P6-07-04: Rapamycin inhibits the stemness of mammary epithelial cells in the premalignant tissues of MMTV-ErbB2 transgenic mice
Dysregulation of microRNA-25 Modulates Airway Smooth Muscle Cell Proliferation via the Mammalian Target of Rapamycin Pathway by Targeting Tuberous Sclerosis …
Deficiency of Myocardial miR-17-92 Cluster Exacerbates Ischemic Injury and Abrogates Rapamycin-Induced Protection in Diabetic Mice
HGG-16. SUSTAINED RESPONSE TO ERLOTINIB AND Rapamycin IN A PATIENT WITH PEDIATRIC ANAPLASTIC OLIGODENDROGLIOMA
Clinical significance of microtubule-associated protein 1 light chain 3 and mammalian target of Rapamycin expression in oral leukoplakia in smokers and never …
Mutational analysis and safety/efficacy in a phase 2 multi-center investigation of ABI-009 (nab-Rapamycin) in patients with advanced malignant perivascular …
Abstract P1-07-27: Prognostic value of programmed death 1/Programmed death ligand 1/mammalian target of Rapamycin/Rictor/Tuberin in human breast cancer
… with everolimus against advanced renal cell carcinoma by dual targeting of Akt/pyruvate kinaseM2 and mechanistic target of Rapamycin complex 1 pathways
Low Dose IL-2 and Rapamycin Leads to Prolongation of Human Islet Allograft Survival by inhibition of IFN-gamma+ T cells and Expansion of FOXP3+ CD25+ Tregs in …
… for optimal inhibition of colon cancer stem cells: Simultaneous inhibition of Insulin-like growth factor-1 receptor-AKT-mammalian target of Rapamycin axis and the …
Antitumor activity of ABI-009 (nab-Rapamycin) in combination with anti-PD1 antibody in a syngeneic mouse model of B16 melanoma
4CPS-143 Topical application of Rapamycin 0.4% for treatment of facial angiokeratomas in a paediatric patient
Defining the Properties of the OS-33 Osteosarcoma Cell Line and Effects of mTORC1 inhibition by Rapamycin
A phase 1b investigation of safety/efficacy of nivolumab and ABI-009 (nab-Rapamycin) in advanced undifferentiated pleomorphic sarcoma (UPS), liposarcoma (LPS) …
… IN HEPATOCELLULAR CARCINOMA-29 CELLS AFTER SEPARATE AND COMBINED ADMINISTRATION OF LITHIUM CARBONATE AND Rapamycin
… Is Dentin Sensitivity: Effect of an Experimental Desensitizing Agent on Stomatitis: Stomatitis Associated With Mammalian Target of Rapamycin inhibition: A Review of …
Target of Rapamycin signaling in plant stress responses
Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor Rapamycin
The mechanistic target of Rapamycin (mTOR): novel considerations as an antiviral treatment
Rapamycin rejuvenates oral health in aging mice
Rapamycin-loaded biomimetic nanoparticles reverse vascular inflammation
Effect of Rapamycin on aging and age-related diseases—past and future
Brain protein synthesis rates in the UM-HET3 mouse following treatment with Rapamycin or Rapamycin with metformin
Is Rapamycin a dietary restriction mimetic?
Exaptive evolution of target of Rapamycin signaling in multicellular eukaryotes
Targeting T-cell senescence and cytokine storm with Rapamycin to prevent severe progression in COVID-19
The target of Rapamycin signalling pathway in ageing and lifespan regulation
Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment
Commentary: Rapamycin for the aging skin
Differential effects of Rapamycin and metformin in combination with Rapamycin on mechanisms of proteostasis in cultured skeletal myotubes
Mechanism of Activation of Mechanistic Target of Rapamycin Complex 1 by Methionine
Rationally designed Rapamycin-encapsulated ZIF-8 nanosystem for overcoming chemotherapy resistance
Mechanistic target of Rapamycin regulates the oligodendrocyte cytoskeleton during myelination
Mechanistic target of Rapamycin in the tumor microenvironment and its potential as a therapeutic target for pancreatic cancer
The regulation of Rapamycin on nutrient metabolism in Nile tilapia fed with high-energy diet
Mechanistic target of Rapamycin signaling in mouse models of accelerated aging
Cannabidiol elevates mechanistic target of Rapamycin inhibitor levels in patients with tuberous sclerosis complex
Rapamycin protects chondrocytes against IL-18-induced apoptosis and ameliorates rat osteoarthritis
Rapamycin induces morphological and physiological changes without increase in lipid content in Ustilago maydis
Rapamycin as a potential repurpose drug candidate for the treatment of COVID-19
APOE genotype-dependent pharmacogenetic responses to Rapamycin for preventing Alzheimer’s disease
Luteolin suppresses bladder cancer growth via regulation of mechanistic target of Rapamycin pathway
Targeting mammalian target of Rapamycin: prospects for the treatment of inflammatory bowel diseases
Treatment with Rapamycin can restore regulatory T-cell function in IPEX patients
Rapamycin maintains NAD+/NADH redox homeostasis in muscle cells
TARGET OF Rapamycin signaling plays a role in Arabidopsis growth promotion by Azospirillum brasilense Sp245
Rapamycin promotes endothelial–mesenchymal transition during stress-induced premature senescence through the activation of autophagy
Rapamycin treatment correlates changes in primary cilia expression with cell cycle regulation in epithelial cells
The anticancer effects of curcumin via targeting the mammalian target of Rapamycin complex 1 (mTORC1) signaling pathway
Enhanced skeletal muscle insulin sensitivity after acute resistance-type exercise is upregulated by Rapamycin-sensitive mTOR complex 1 inhibition
Lowe syndrome patient cells display mTOR-and RhoGTPase-dependent phenotypes alleviated by Rapamycin and statins
Cognitive impairment with diabetes mellitus and metabolic disease: innovative insights with the mechanistic target of Rapamycin and circadian clock gene pathways
Targeted pathological collagen delivery of sustained-release Rapamycin to prevent heterotopic ossification
The plant target of Rapamycin: a conduc TOR of nutrition and metabolism in photosynthetic organisms
The effect of Rapamycin on bovine oocyte maturation success and metaphase telomere length maintenance
Rapamycin regulates the balance between cardiomyocyte apoptosis and autophagy in chronic heart failure by inhibiting mTOR signaling
Rapamycin affects palmitate-induced lipotoxicity in osteoblasts by modulating apoptosis and autophagy
Effects of Rapamycin and AZD3463 combination on apoptosis, autophagy, and cell cycle for resistance control in breast cancer
Rapamycin attenuates the paraquat‐induced pulmonary fibrosis through activating Nrf2 pathway
Metformin rescues Rapamycin-induced mitochondrial dysfunction and attenuates rheumatoid arthritis with metabolic syndrome
Discovery of a brain-penetrant ATP-competitive inhibitor of the mechanistic target of Rapamycin (mTOR) for CNS disorders
Rapamycin preserves the primordial follicle pool during cisplatin treatment in vitro and in vivo
Wide electrochemical window of screen-printed electrode for determination of Rapamycin using ionic liquid/graphene composites
The mechanistic target of Rapamycin pathway downregulates bone morphogenetic protein signaling to promote oligodendrocyte differentiation
Target of Rapamycin regulates potassium uptake in Arabidopsis and potato
Steady Augmentation of Anti-Osteoarthritic Actions of Rapamycin by Liposome-Encapsulation in Collaboration with Low-Intensity Pulsed Ultrasound
Rapidly dissolving microneedles for the delivery of cubosome-like liquid crystalline nanoparticles with sustained release of Rapamycin
Target of Rapamycin signaling is tightly and differently regulated in the plant response under distinct abiotic stresses
Metabolite regulatory interactions control plant respiratory metabolism via Target of Rapamycin (TOR) kinase activation
Target of Rapamycin regulates genome methylation reprogramming to control plant growth in Arabidopsis
Linc‐ROR promotes the progression of breast cancer and decreases the sensitivity to Rapamycin through miR‐194‐3p targeting MECP2
Nanotoxicology of an Elastin-like Polypeptide Rapamycin Formulation for Breast Cancer
Transdermal delivery of Rapamycin with poor water-solubility by dissolving polymeric microneedles for anti-angiogenesis
Rapamycin relieves the cataract caused by ablation of Gja8b through stimulating autophagy in zebrafish
Functional analysis target of Rapamycin (TOR) on the Penaeus vannamei in response to acute low temperature stress
Rapamycin and hydroxychloroquine combination alters macrophage polarization and sensitizes glioblastoma to immune checkpoint inhibitors
Deregulated mTOR (mechanistic target of Rapamycin kinase) is responsible for autophagy defects exacerbating kidney stone development
Radiosensitising cancer using Phosphatidylinositol-3-Kinase (PI3K), Protein Kinase B (AKT) or mammalian target of Rapamycin (mTOR) Inhibitors
Rapamycin inhibits pathogen transmission in mosquitoes by promoting immune activation
Inflammation‐induced mammalian target of Rapamycin signaling is essential for retina regeneration
Targeting mechanistic target of Rapamycin complex 1 restricts proinflammatory T cell differentiation and ameliorates Takayasu arteritis
Unlike dietary restriction, Rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair‐deficient mice
Target Of Rapamycin pathway in the white-rot fungus Phanerochaete chrysosporium
Rapamycin and mTORC2 inhibition synergistically reduce contraction‐stimulated muscle protein synthesis
Upregulation of Akt/Raptor signaling is associated with Rapamycin resistance of breast cancer cells
PKC downregulation upon Rapamycin treatment attenuates mitochondrial disease
Microalgal Target of Rapamycin (TOR): A Central Regulatory Hub for Growth, Stress Response and Biomass Production
Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or Rapamycin
Rapamycin treatment maintains developmental potential of oocytes in mice and follicle reserve in human cortical fragments grafted into immune-deficient mice
Fpr1, a primary target of Rapamycin, functions as a transcription factor for ribosomal protein genes cooperatively with Hmo1 in Saccharomyces cerevisiae
Inhaled Rapamycin solid lipid nano particles for the treatment of Lymphangioleiomyomatosis
Rapamycin and MCC950 modified gut microbiota in experimental autoimmune encephalomyelitis mouse by brain gut axis
TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and Rapamycin-induced MNK-eIF4E signaling
Mechanistic Target of Rapamycin Signaling Activation Antagonizes Autophagy To Facilitate Zika Virus Replication
The efficacy and safety of topical Rapamycin–calcitriol for facial angiofibromas in patients with tuberous sclerosis complex: a prospective, double‐blind, randomized …
Rapamycin–PLGA microparticles prevent senescence, sustain cartilage matrix production under stress and exhibit prolonged retention in mouse joints
Sirolimus and other mechanistic target of Rapamycin inhibitors directly activate latent pathogenic human polyomavirus replication
Angiotensin-converting enzyme inhibitor rapidly ameliorates depressive-type behaviors via bradykinin-dependent activation of mammalian target of Rapamycin …
Nanoporous Gold Monolith for High Loading of Unmodified Doxorubicin and Sustained Co-Release of Doxorubicin-Rapamycin
An exploratory study of metformin with or without Rapamycin as maintenance therapy after induction chemotherapy in patients with metastatic pancreatic …
Low‐dose Rapamycin‐induced autophagy in cochlear outer sulcus cells
Mammalian Target of Rapamycin Complex 2 Signaling Is Required for Liver Regeneration in a Cholestatic Liver Injury Murine Model
mTOR Mysteries: Nuances and Questions About the Mechanistic Target of Rapamycin in Neurodegeneration
Supply of methionine and arginine alters phosphorylation of mechanistic target of Rapamycin (mTOR), circadian clock proteins, and α-s1-casein abundance in …
The mammalian target of Rapamycin (mTOR) kinase mediates haloperidol-induced cataleptic behavior
Rapamycin extends life span in ApcMin/+ colon cancer FAP model
Advances in mammalian target of Rapamycin kinase inhibitors: application to devices used in the treatment of coronary artery disease
Effects of glycosylation on the bioactivity of Rapamycin
Rapamycin inhibits Nf-ΚB activation by autophagy to reduce catabolism in human chondrocytes
Mitochondrial spongiotic brain disease: astrocytic stress and harmful Rapamycin and ketosis effect
Target of Rapamycin signaling inhibits autophagy in sea cucumber Apostichopus japonicus
Bioproperties, Nanostructured System and Analytical and Bioanalytical Methods for Determination of Rapamycin: A Review
Short-and long-term effects of Rapamycin on ischemic damage and apoptotic changes in torsion of rat testes
Therapeutic effects of Rapamycin and surgical decompression in a rabbit spinal cord injury model
Effects of Rapamycin Combined with Cisplatin on Tumor Necrosis Factor TNF-α in MG-63 Cells
Sex differences in changes of protein synthesis with Rapamycin treatment are minimized when metformin is added to Rapamycin
Inhibitory efficacy of Rapamycin against potato white mold
Gene transfer in adeno-associated virus seropositive rhesus macaques following Rapamycin treatment and subcutaneous delivery of AAV6, but not retargeted AAV6 …
Wheat Germination Is Dependent on Plant Target of Rapamycin Signaling
Differential roles and activation of mammalian target of Rapamycin complexes 1 and 2 during cell migration in prostate cancer cells
Dietary and Pharmacological Interventions That Inhibit Mammalian Target of Rapamycin Activity Alter the Brain Expression Levels of Neurogenic and Glial Markers in …
Rapamycin increases the incidence of neuropsychiatric illness in kidney transplant patients through the suppression of neural stem cells
Roles of the mammalian target of Rapamycin (mTOR) signaling pathway in the repair of hyperoxia-induced acute lung injury.
Rapamycin‐mediated mouse lifespan extension: Late‐life dosage regimes with sex‐specific effects
Mammalian target of Rapamycin-RhoA signaling impairments in direct striatal projection neurons induce altered behaviors and striatal physiology in mice
The mTOR inhibitor Rapamycin prevents general anesthesia-induced changes in synaptic transmission and mitochondrial respiration in late postnatal mice
Low nitrogen induces root elongation via auxin-induced acid growth and auxin-regulated target of Rapamycin (TOR) pathway in maize
Resveratrol potentiates the anti-tumor effects of Rapamycin in papillary thyroid cancer: PI3K/AKT/mTOR pathway involved
… analysis of neonatal regenerative myocardium revealed important roles of checkpoint kinase 1 via activating mammalian target of Rapamycin C1/Ribosomal protein …
Epidermal mammalian target of Rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation
Lithium chloride combination with Rapamycin for the treatment of COVID-19 pneumonia
Dendrimer-Mediated Targeted Delivery of Rapamycin to Tumor-Associated Macrophages Improves Systemic Treatment of Glioblastoma
PD-L1 cellular nanovesicles carrying Rapamycin inhibit alloimmune responses in transplantation
Melatonin regulates the ovarian function and enhances follicle growth in aging laying hens via activating the mammalian target of Rapamycin pathway
Acetate regulates milk fat synthesis through the mammalian target of Rapamycin/eukaryotic initiation factor 4E signaling pathway in bovine mammary epithelial cells
Neurobehavioral effects in rats with experimentally induced glioblastoma after treatment with the mTOR-inhibitor Rapamycin
Short-Term Rapamycin Preconditioning Diminishes Therapeutic Efficacy of Human Adipose-Derived Stem Cells in a Murine Model of Multiple Sclerosis
Intralacrimal Sustained Delivery of Rapamycin Shows Therapeutic Effects without Systemic Toxicity in a Mouse Model of Autoimmune Dacryoadenitis Characteristic of …
Fibro-adipose vascular anomaly (FAVA): three case reports with an emphasis on the mammalian target of Rapamycin (mTOR) pathway
DNA-and telomere-damage does not limit lifespan: evidence from Rapamycin
Spermidine and Rapamycin Reveal Distinct Autophagy Flux Response and Cargo Receptor Clearance Profile
Properties of Rapamycin solid lipid nanoparticles for lymphatic access through the lungs & part I: the effect of size
Transient and late-life Rapamycin for healthspan extension
Role of the Mammalian Target of Rapamycin Pathway in Liver Cancer: From Molecular Genetics to Targeted Therapies
Hyperglycemia-induced VEGF and ROS production in retinal cells is inhibited by the mTOR inhibitor, Rapamycin
Rapamycin restrains platelet procoagulant responses via FKBP-mediated protection of mitochondrial integrity
Hypothalamic orexin and mechanistic target of Rapamycin activation mediate sleep dysfunction in a mouse model of tuberous sclerosis complex
Rapamycin Plus Vildagliptin to Recover β-Cell Function in Long-Standing Type 1 Diabetes: A Double-Blind, Randomized Trial
Differential Effects of Rapamycin on Glucose Metabolism in Nine Inbred Strains
The effect of a ketogenic diet and synergy with Rapamycin in a mouse model of breast cancer
inhibition of mechanistic target of Rapamycin signaling decreases levels of O-GlcNAc transferase and increases serotonin release in the human placenta
Implications of maraviroc and/or Rapamycin in a mouse model of fragility
Properties of Rapamycin solid lipid nanoparticles for lymphatic access through the lungs & part II: the effect of nanoparticle charge
Potential new therapy of Rapalink‐1, a new generation mammalian target of Rapamycin inhibitor, against sunitinib‐resistant renal cell carcinoma
Visualizing protein-protein interactions in plants by Rapamycin-dependent delocalization
Mmi1, the yeast ortholog of mammalian translationally controlled tumor protein (TCTP), negatively affects Rapamycin-induced autophagy in post-diauxic growth phase
Efficacy of AAV8-hUGT1A1 with Rapamycin in neonatal, suckling, and juvenile rats to model treatment in pediatric CNs patients
… expression of activator proteins that control follicle reserve after ovarian tissue cryopreservation/transplantation and primordial follicle loss prevention by Rapamycin
Pharmacophore-guided fragment-based design of novel mammalian target of Rapamycin inhibitors: extra precision docking, fingerprint-based 2D and atom-based 3D …
The Release of cyclophilin a from Rapamycin-stimulated vascular smooth muscle cells mediated by myosin ii activation: involvement of apoptosis but not autophagy
Mechanistic target of Rapamycin kinase (mTOR) is required for spermatogonial proliferation and differentiation in mice
A Novel Combination Treatment with Honokiol and Rapamycin Effectively Restricts c-Met-Induced Growth of Renal Cancer Cells, and also Inhibits the Expression of …
Elevated glucosylsphingosine in Gaucher disease induced pluripotent stem cell neurons deregulates lysosomal compartment through mammalian target of Rapamycin …
Rapamycin inhibits B-cell activating factor (BAFF)-stimulated cell proliferation and survival by suppressing Ca2+-CaMKII-dependent PTEN/Akt-Erk1/2 signaling …
Thioredoxin-1 maintains mitochondrial function via mechanistic target of Rapamycin signalling in the heart
Azospirillum brasilense Sp245 lipopolysaccharides induce target of Rapamycin signaling and growth in Arabidopsis thaliana
Rapamycin Treatment of Tendon Stem/Progenitor Cells Reduces Cellular Senescence by Upregulating Autophagy
… of Autophagy in Glioblastoma Treatment With Phosphoinositide 3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin Signaling Pathway Inhibitors
Mammalian target of Rapamycin and p70S6K mediate thrombin-induced nuclear factor-κB activation and IL-8/CXCL8 release in human lung epithelial cells
Resveratrol, Rapamycin and Metformin as Modulators of Antiviral Pathways
Effects of Rapamycin on osteosarcoma cell proliferation and apoptosis by inducing autophagy
Rapamycin for aging stem cells
Rapamycin: Drug Repurposing in SARS-CoV-2 Infection
Efficacy of AAV8-hUGT1A1 with Rapamycin in neonatal, suckling, and juvenile rats to model treatment in pediatric CNs patients
Target of Rapamycin (TOR) negatively regulates ethylene signals in Arabidopsis
inhibition of the mechanistic target of Rapamycin induces cell survival via MAPK in tuberous sclerosis complex
Cyclopamine and Rapamycin Synergistically Inhibit mTOR Signalling in Mouse Hepatocytes, Revealing an Interaction of Hedgehog and mTOR Signalling in the Liver
Structural insights into CYP107G1 from Rapamycin-producing Streptomyces Rapamycinicus
Rapamycin prevents spontaneous abortion by triggering decidual stromal cell autophagy-mediated NK cell residence
Genetically encoded biosensors for the detection of Rapamycin: toward the screening of agonists and antagonists
B Cell Depletion Eliminates FVIII Memory B Cells and Enhances AAV8-coF8 Immune Tolerance Induction When Combined With Rapamycin
Rapamycin, by Inhibiting mTORC1 Signaling, Prevents the Loss of Striatal Bidirectional Synaptic Plasticity in a Rat Model of L-DOPA-Induced Dyskinesia
Rapamycin Induces an eNOS (Endothelial Nitric Oxide Synthase) Dependent Increase in Brain Collateral Perfusion in Wistar and Spontaneously Hypertensive Rats
mTOR Blockade by Rapamycin in Spondyloarthritis: Impact on Inflammation and New Bone Formation in vitro and in vivo
Mitochondrial dysfunction contributes to Rapamycin-induced apoptosis of Human Glioblastoma Cells-A synergistic effect with Temozolomide
Rapamycin Promotes Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells in a Stage-Dependent Manner
Rapamycin and abundant TCR stimulation are required for the generation of stable human induced regulatory T cells
Crosstalk of the Caspase Family and Mammalian Target of Rapamycin Signaling
Rapamycin-Loaded mPEG-PLGA Nanoparticles Ameliorate Hepatic Steatosis and Liver Injury in Non-alcoholic Fatty Liver Disease
Interactions of FK506 and Rapamycin With FK506 Binding Protein 12 in Opportunistic Human Fungal Pathogens
Rapamycin-loaded lipid nanocapsules induce selective inhibition of the mTORC1-signaling pathway in glioblastoma cells
Cytotoxicity of nonylphenol on spermatogonial stem cells via phosphatidylinositol-3-kinase/protein kinase B/mammalian target of Rapamycin pathway
Copper induces hepatocyte autophagy via the mammalian targets of the Rapamycin signaling pathway in mice
Rapamycin and dexamethasone during pregnancy prevent tuberous sclerosis complex–associated cystic kidney disease
Effects of mammalian target of Rapamycin inhibitors on fibrosis after trabeculectomy
Phase I Trial of Encapsulated Rapamycin in Prostate Cancer Patients Under Active Surveillance to Prevent Progression
SFCE-RAPIRI Phase I Study of Rapamycin Plus Irinotecan: A New Way to Target Intra-Tumor Hypoxia in Pediatric Refractory Cancers
Effect of Rapamycin on repeated immobilization stress-induced immune alterations in the rat spleen
Reduction of FoxP3+ Tregs by an immunosuppressive protocol of Rapamycin plus Thymalfasin and Huaier extract predicts positive survival benefits in a rat …
The Rapamycin analog Everolimus reversibly impairs male germ cell differentiation and fertility in the mouse
Protective Effects of Rapamycin on Trabecular Meshwork Cells in Glucocorticoid-Induced Glaucoma Mice
Insulin potentiates essential amino acids effects on mechanistic target of Rapamycin complex 1 signaling in MAC-T cells
Mechanistic target of Rapamycin-mediated autophagy is involved in the alleviation of lipopolysaccharide-induced acute lung injury in rats
Rapamycin alleviates renal damage in mice with systemic lupus erythematosus through improving immune response and function
Rapamycin inhibits lung squamous cell carcinoma growth by downregulating glypican-3/Wnt/β-catenin signaling and autophagy
Mammalian target of Rapamycin (mTOR) inhibitors and skin cancer risk in nonrenal solid organ transplant recipients: systematic review and meta‐analysis
Effect of mechanistic/mammalian target of Rapamycin complex 1 on mitochondrial dynamics during skeletal muscle hypertrophy
Rictor promotes tumor progression of Rapamycin-insensitive triple-negative breast cancer cells
Comparing mTOR inhibitor Rapamycin with Torin-2 within the RIST molecular-targeted regimen in neuroblastoma cells
Novel brain permeant mTORC1/2 inhibitors are as efficacious as Rapamycin or everolimus in mouse models of acquired partial epilepsy and tuberous sclerosis …
Topical administration of Rapamycin promotes retinal ganglion cell survival and reduces intraocular pressure in a rat glaucoma model
MYC‐binding lncRNA EPIC1 promotes AKT‐mTORC1 signaling and Rapamycin resistance in breast and ovarian cancer
Human monocyte-derived macrophage responses to M. tuberculosis differ by the host’s tuberculosis, diabetes or obesity status, and are enhanced by Rapamycin
… RNA 0152 promotes hepatocellular carcinoma progression by regulating phosphatidylinositol 3-Kinase/Akt/mammalian target of Rapamycin signaling pathway through …
Optimized Rapamycin-loaded PEGylated PLGA nanoparticles: Preparation, characterization and pharmacokinetics study
Modulatory effect of Rapamycin and tacrolimus on monocyte-derived dendritic cells phenotype and function
Rapamycin improves renal injury induced by Iodixanol in diabetic rats by deactivating the mTOR/p70S6K signaling pathway
Rapamycin inhibits AR signaling pathway in prostate cancer by interacting with the FK1 domain of FKBP51
… angiogenic function of human lung microvascular endothelial cells via LAT1 (L-type amino acid transporter 1)-mediated mTOR (Mammalian Target of Rapamycin) …
Rapamycin Reduces Cervical Cancer Cells Viability in Hypoxic Condition: Investigation of the Role of Autophagy and Apoptosis
Proteasome activity and expression of mammalian target of Rapamycin signaling factors in skeletal muscle of dairy cows supplemented with conjugated linoleic acids …
In Silico Strategy for Targeting the mTOR Kinase at Rapamycin Binding Site by Small Molecules
Metastatic role of mammalian target of Rapamycin signaling activation by chemoradiotherapy in advanced rectal cancer
Chloroquine and Rapamycin Augment Interleukin-37 Expression via the LC3, ERK, and AP-1 Axis in the Presence of Lipopolysaccharides
Gemcitabine and Rapamycin Exhibit Additive Effect against Osteosarcoma by Targeting Autophagy and Apoptosis
… Study of Immunomodulatory Agents to Induce Human T Regulatory (Treg) Cells: Preferential Treg-Stimulatory Effect of Prednisolone and Rapamycin
Rapamycin Inhibitors for Eye Squamous Cell Carcinoma after Renal Transplantation: A Case Report
Autophagy induction by Rapamycin ameliorates experimental colitis and improves intestinal epithelial barrier function in IL-10 knockout mice
A high-dose Rapamycin treatment alleviates hepatopulmonary syndrome in cirrhotic rats
Antifungal activity of Rapamycin on Botryosphaeria dothidea and its effect against Chinese hickory canker
Protective effects of glucagon‐like peptide‐1 on cardiac remodeling by inhibiting oxidative stress through mammalian target of Rapamycin complex 1/p70 ribosomal …
Toxicity Evaluation of a Novel Rapamycin Liposomal Formulation After Subconjunctival and Intravitreal Injection
Results of a phase Ib trial of encapsulated Rapamycin in prostate cancer patients under active surveillance to prevent progression.
Limited efficacy of Rapamycin monotherapy in vascularized composite allotransplantation
inhibition of the mammalian target or Rapamycin (mTOR): a potential therapeutic strategy for multiple system atrophy
HIF-1α-Mediated Telomerase Reverse Transcriptase Activation Inducing Autophagy Through Mammalian Target of Rapamycin Promotes Papillary Thyroid Carcinoma …
Rapamycin Ameliorates Cognitive Impairments and Alzheimer’s Disease-Like Pathology with Restoring Mitochondrial Abnormality in the Hippocampus of …
Rapamycin-Induced Autophagy Promotes the Chondrogenic Differentiation of Synovium-Derived Mesenchymal Stem Cells in the Temporomandibular Joint in …
Tacrolimus, a Rapamycin target protein inhibitor, exerts anti-cystic echinococcosis effects both in vitro and in vivo
Mammalian target of Rapamycin inhibitors after post-transplant hepatocellular carcinoma recurrence: Is it too late?
Proteomics Approach of Rapamycin Anti-Tumoral Effect on Primary and Metastatic Canine Mammary Tumor Cells In Vitro
Rapamycin Improves Recognition Memory and Normalizes Amino-Acids and Amines Levels in the Hippocampal Dentate Gyrus in Adult Rats Exposed to Ethanol …
Exosomes secreted from mesenchymal stem cells mediate the regeneration of endothelial cells treated with Rapamycin by delivering pro-angiogenic microRNAs
Rapamycin is Effective for Upper but not for Lower Gastrointestinal Crohn’s Disease-Related Stricture: A Pilot Study
Upregulation of 6‐phosphofructo‐2‐kinase (PFKFB3) by hyperactivated mammalian target of Rapamycin complex 1 is critical for tumor growth in tuberous sclerosis …
mTORC1 (Mechanistic Target of Rapamycin Complex 1) Signaling in Endothelial and Smooth Muscle Cells Is Required for Vascular Function
The mTORC1 inhibitor Rapamycin and the mTORC1/2 inhibitor AZD2014 impair the consolidation and persistence of contextual fear memory
Rapamycin could increase the effects of melatonin against age-dependent bone loss
Chronic low-dose Rapamycin treatment fine tunes cardioprotective signalling in ischaemia-reperfused diabetic hearts
Low-Dose Interleukin-2 Combined With Rapamycin Led to an Expansion of CD4+ CD25+ FOXP3+ Regulatory T Cells and Prolonged Human Islet Allograft Survival in …
Rapamycin alleviates cognitive impairment in murine vascular dementia: The enhancement of mitophagy by PI3K/AKT/mTOR axis
… sensors and reproductive hypothalamo-pituitary ovarian axis (HPO) in female mammals: role of mTOR (mammalian target of Rapamycin), AMPK (AMP-activated …
Rapamycin ameliorates corneal injury after alkali burn through methylation modification in mouse TSC1 and mTOR genes
Blockade of the mTOR signaling pathway with Rapamycin ameliorates aristolochic acid nephropathy
STAT3-miR-17/20 signalling axis plays a critical role in attenuating myocardial infarction following Rapamycin treatment in diabetic mice
Adiponectin receptor 1 variants contribute to hypertrophic cardiomyopathy that can be reversed by Rapamycin
Activation of the Akt/mammalian target of Rapamycin pathway in combined hepatocellular carcinoma and cholangiocarcinoma: significant correlation between p-4E …
Topical Rapamycin versus betamethasone dipropionate ointment for treating oral erosive lichen planus: a randomized, double‐blind, controlled study
Rapamycin Alleviates the Symptoms of Multiple Sclerosis in Experimental Autoimmune Encephalomyelitis (EAE) Through Mediating the TAM-TLRs-SOCS …
Rapamycin‐based graft‐versus‐host disease prophylaxis increases the immunosuppressivity of myeloid‐derived suppressor cells without affecting T cells and anti …
Rapamycin Protects Skin Fibroblasts From UVA-Induced Photoaging by inhibition of p53 and Phosphorylated HSP27
Rapamycin synergizes the cytotoxic effects of MEK inhibitor binimetinib and overcomes acquired resistance to therapy in melanoma cell lines in vitro
Effects of co-administration of Rapamycin and evening primrose/hemp seed oil supplement on immunologic factors and cell membrane fatty acids in experimental …
Sirt4 Modulates Oxidative Metabolism and Sensitivity to Rapamycin Through Species-Dependent Phenotypes in Drosophila mtDNA Haplotypes
NEAT1/hsa-miR-372-3p axis participates in Rapamycin-induced lipid metabolic disorder
Comparison of Two Strategies Based On Mammalian Target of Rapamycin Inhibitors In Secondary Prevention of Non‐Melanoma Skin Cancer After Kidney …
Correction: An ATP-competitive mammalian target of Rapamycin inhibitor reveals Rapamycin-resistant functions of mTORC1.
… replacement with composite mixture of shrimp hydrolysate and plant proteins on growth performance, feed utilization, and target of Rapamycin pathway in largemouth …
… amino acid transporter: Sodium-coupled neutral amino acid transporter 2 inhibits cell growth and mammalian target of Rapamycin complex 1 pathway in …
Metformin and Rapamycin protect cells from vital dye–induced damage in retinal pigment epithelial cells and in vivo
Rapamycin Preserves Neural Tissue, Promotes Schwann Cell Myelination and Reduces Glial Scar Formation After Hemi-Contusion Spinal Cord Injury in Mice
Persistent myopathy despite release of partial obstruction: in vivo reversal of dysfunction and transcriptional responses using Rapamycin
Exercise intervention attenuates neuropathic pain in diabetes via mechanisms of mammalian target of Rapamycin (mTOR)
Role of exercise and Rapamycin on the expression of energy metabolism genes in liver tissues of rats fed a high‑fat diet
The protective effects of Rapamycin pretreatment on ovarian damage during ovarian tissue cryopreservation and transplantation
Characteristics of Lymphedema in Patients Treated with Mammalian Target of Rapamycin Inhibitors
Protective effects of Rapamycin on the retinal vascular bed during the vaso‐obliteration phase in mouse oxygen‐induced retinopathy model
Rapamycin Alleviates Hypertriglyceridemia-Related Acute Pancreatitis via Restoring Autophagy Flux and Inhibiting Endoplasmic Reticulum Stress
Microvessel density and vascular endothelial growth factor receptors in breast carcinoma under the influence of Rapamycin and platelet factor 4
Mitochondrial General Control of Amino Acid Synthesis 5 Like 1 Regulates Glutaminolysis, Mammalian Target of Rapamycin Complex 1 Activity, and Murine Liver …
Matrix-assisted pulsed laser evaporation-deposited Rapamycin thin films maintain antiproliferative activity
The Effectiveness of Rapamycin Combined with Eltrombopag in Murine Models of Immune-Mediated Bone Marrow Failure
Rapamycin induces megakaryocytic differentiation through increasing autophagy in Dami cells
Comprehensive Analysis of the Immunomodulatory Effects of Rapamycin on Human T Cells in Graft‐versus‐Host Disease Prophylaxis
Tumor Susceptibility Gene 101 facilitates Rapamycin-induced autophagic flux in neuron cells
FTY720 Suppresses Liver Tumor Growth and Metastasis by Reducing Circulating Regulating T Cells and Enhancing the Anti-Tumor Effect of Rapamycin
Oral Preconditioning of Donors After Brain Death With Calcineurin Inhibitors vs. Inhibitors of Mammalian Target for Rapamycin in Pig Kidney Transplantation
Polymeric nanoparticles containing Rapamycin and autoantigen induce antigen-specific immunological tolerance for preventing vitiligo in mice
Rapamycin enhances BCG-specific γδ T cells during intravesical BCG therapy for non-muscle invasive bladder cancer: a randomized, double-blind study
Ultrasound Stimulation Increases Neurite Regeneration in Injured Dorsal Root Ganglion Neurons through Mammalian Target of Rapamycin Activation
Target of Rapamycin in Control of Autophagy: Puppet Master and Signal Integrator
Synergistic Effect of 3-Bromopyruvate in Combination with Rapamycin Impacted Neuroblastoma Metabolism by Inhibiting Autophagy
Role of mechanistic target of Rapamycin and autophagy in alcohol-induced adipose atrophy and liver injury
Targeted inhibition of the epidermal growth factor receptor and mammalian target of Rapamycin signaling pathways in olmsted syndrome
… by chemokine (cc motif) ligand 3 promote the progression of breast cancer via phosphoinositide 3-kinase-protein kinase b-mammalian target of Rapamycin …
Retraction: Rapamycin Inhibits Proliferation of Hemangioma Endothelial Cells by Reducing HIF-1-Dependent Expression of VEGF
… sensor based on carbon paste electrode modified with polypyrrole/multi‐walled carbon nanotubes for the electrochemical detection of cytostatic drug Rapamycin
Comparison of Rapamycin and methylprednisolone for treating inflammatory muscle disease in a murine model of experimental autoimmune myositis
Low Dose IL-2 Combined with Rapamycin Led to an Expansion of CD4+ CD25+ FOXP3+ Tregs and Prolonged Human Islet-allograft Survival in Humanized Mice
Rapamycin Inhibited Pyroptosis and Reduced the Release of IL-1β and IL-18 in the Septic Response
Methionine controls insulin/mammalian target of Rapamycin complex 1 activity by modulating tuberous sclerosis complex 2 stability
Reactive Oxygen Species‐Scavenging Scaffold with Rapamycin for Treatment of Intervertebral Disk Degeneration
Cell synchronization by Rapamycin improves the developmental competence of buffalos (Bubalus bubalis) somatic cell nuclear transfer embryos
Therapeutic Effect of Rapamycin on Aortic Dissection in Mice
Rapamycin inhibits proliferation and apoptosis of retinoblastoma cells through PI3K/AKT signaling pathway
Rapamycin-dependent delocalization as a novel tool to reveal protein-protein interactions in plants
… Membrane Cassette Transport Protein A1 via Adenosine Monophosphate-Activated Protein Kinase/Mammalian Target of Rapamycin Signaling in Macrophages
Protective effect of Rapamycin against acrylamide‐induced hepatotoxicity: The associations between autophagy, apoptosis, and necroptosis
Physiological function of FKBP12, a primary target of Rapamycin/FK506: a newly identified role in transcription of ribosomal protein genes in yeast
Sustained response to erlotinib and Rapamycin in a patient with pediatric anaplastic oligodendroglioma
Dermatological adverse events associated with use of oral mechanistic target of Rapamycin inhibitors in a cohort of individuals with tuberous sclerosis complex
Porcine circovirus 3 capsid protein induces autophagy in HEK293T cells by inhibiting phosphorylation of the mammalian target of Rapamycin
Use of topical Rapamycin in acral pseudolymphomatous angiokeratoma of children (APACHE): A report of two cases and review of the literature
Rapamycin (sirolimus) in treatment of recurrent intravenous leiomyomatosis: a case report
Genes responsive to Rapamycin and serum deprivation are clustered on chromosomes and undergo reorganization within local chromatin environments
Short-term oral Rapamycin prevents age-related learning impairment in mice
… in plant‐rich diets affects growth, feed utilization, body composition, blood biochemical indices and gene expressions of the target of Rapamycin signaling pathway in …
Investigation of the effects of Rapamycin on the mTOR pathway and apoptosis in metastatic and non-metastatic human breast cancer cell lines
Delivery of Rapamycin by Liposomes Synergistically Enhances the Chemotherapy Effect of 5-Fluorouracil on Colorectal Cancer
Rapamycin and 3-Methyladenine Influence the Apoptosis, Senescence, and Adipogenesis of Human Adipose-Derived Stem Cells by Promoting and Inhibiting …
Rapamycin-Preactivated Autophagy Enhances Survival and Differentiation of Mesenchymal Stem Cells After Transplantation into Infarcted Myocardium
S100A8 and S100A9 promote endothelial cell activation through the RAGE‑mediated mammalian target of Rapamycin complex 2 pathway
Rapamycin Pretreatment Alleviates Cerebral Ischemia/Reperfusion Injury in Dose-Response Manner Through inhibition of the Autophagy and NFκB Pathways in Rats
Metabolic and Renal Effects of Mammalian Target of Rapamycin Inhibitors Treatment After Liver Transplantation: Real-Life Single-Center Experience
Use of Topical Sirolimus (Rapamycin) for Treating Confluent and Reticulated Papillomatosis
The Antidiabetic Agent Acarbose Improves Anti-PD-1 and Rapamycin Efficacy in Preclinical Renal Cancer
Effect and mechanism of Rapamycin on proliferation and apoptosis of human lung cancer cells
Iron Overload Impairs Autophagy: Effects of Rapamycin in Ameliorating Iron-Related Memory Deficits
Scopoletin Activates Adenosine Monophosphate-Activated Protein Kinase/Mammalian Target of Rapamycin Signaling Pathway and Improves Functional Recovery …
… Cancer Progression Through Directly Targeting Phosphatidylinositol 5‐Phosphate 4‐Kinase Type‐2 Gamma to Facilitate Mammalian Target of Rapamycin Signaling …
Role of Akt and mammalian target of Rapamycin signalling in insulin-like growth factor 1-mediated cell proliferation in porcine Sertoli cells
Rapamycin prevents retinal neovascularization by downregulation of cyclin D1 in a mouse model of oxygen-induced retinopathy
… -like peptide-1 alleviates diabetic kidney disease through activation of autophagy by regulating AMP-activated protein kinase-mammalian target of Rapamycin pathway
… Acid Receptor 5 (LPAR5) Plays a Significance Role in Papillary Thyroid Cancer via Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin …
Growth inhibition and suppression of the mTOR and Wnt/β‐catenin pathways in T‐acute lymphoblastic leukemia by Rapamycin and MYCN depletion
Effect of Rapamycin on the Radio-Sensitivity of Cultured Tumor Cells Following Boron Neutron Capture Reaction
Target of Rapamycin: function in abiotic stress tolerance in Arabidopsis and its involvement in a possible cross-talk with ribosomal proteins
… /reperfusion injury by targeting connective tissue growth factor through the adenosine 5′-monophosphate-activated protein kinase/mammalian target of Rapamycin …
Topical Rapamycin for acanthosis nigricans in the Fitzpatrick IV/V adolescent population
Balancing Growth and Defense: Role of Target of Rapamycin and SNF1‐Related Protein Kinase 1 in Stress Signaling in Plants
… Disease by Inhibiting Apoptosis and Promoting Autophagy via Reactive Oxygen Species/Phosphatidylinositol 3-Kinase/AKT/Mammalian Target of Rapamycin …
… to Esophageal Squamous Cell Carcinoma Progression via CCR8-Mediated Akt/Proline-Rich Akt Substrate of 40 kDa/Mammalian Target of Rapamycin …
… Cell Proliferation and Progression of Lung Adenocarcinoma and Involves the Phosphoinositide 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin …
Rapamycin Overproduction by Combined Mutational Study
A systematic review and meta-analysis protocol of clinical characteristics and prognostic significance of mammalian target of Rapamycin for gastric cancer …
Rapamycin Treatment Reduces Acute Myocarditis Induced by Trypanosoma cruzi Infection
CLINICAL-EXPERIMENTAL EXPERIENCE WITH Rapamycin IN VISCERAL TRANSPLANTATION
Rapamycin Eyedrops Increased CD4+ Foxp3+ Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface
Chronic Mechanistic Target of Rapamycin inhibition: Preventing Cancer to Delay Aging or Vice Versa?
Down-Regulation of the Mammalian Target of Rapamycin (mTOR) Pathway Mediates the Effects of the Paeonol-Platinum (II) Complex in Human Thyroid …
Mammalian Target of Rapamycin Signaling Enhances Ovalbumin-Induced Neutrophilic Airway Inflammation By Promoting Th17 Cell Polarization in Murine …
Arenobufagin Inhibits the Phosphatidylinositol 3-kinase/Protein Kinase B/Mammalian Target of Rapamycin Pathway and Induces Apoptosis and Autophagy in …
CARDIOVASCULAR OUTCOMES OF Rapamycin-BASED IMMUNOSUPPRESSION IN KIDNEY TRANSPLANT RECIPIENTS: A SINGLE CENTER …
Stomach-specific c-Myc overexpression drives gastric adenoma in mice through AKT/mammalian target of Rapamycin signaling
Protein blend and casein supplementations before inactive phase similarly activate mechanistic target of Rapamycin signaling in rat skeletal muscle
Gene expression and regulatory factors of the mechanistic target of Rapamycin (mTOR) complex 1 predict mammalian longevity
Effectiveness of low dose of Rapamycin in preventing seizure-induced anxiety-like behaviour, cognitive impairment, and defects in neurogenesis in developing rats
Regulatory effect of apoptosis on morphological changes in cell mass of porcine blastocyst through supplementation of Rapamycin during in vitro culture
Identification of 3′, 4′, 5′-trihydroxyflavone as an mammalian target of Rapamycin inhibitor and its suppressive effects on dextran sulfate sodium-induced ulcerative …
Living Donor Preemptive Kidney Transplantation in Tuberous Sclerosis Complex Patient and the Role of Mammalian Target of Rapamycin Inhibitor: A Case Report
Rapamycin and Rapalogs
miR-331-3p is involved in glucocorticoid resistance reversion by Rapamycin through suppression of the MAPK signaling pathway
Suppression of Allograft Fibrosis by Regulation of Mammalian Target of Rapamycin-Related Protein Expression in Kidney-Transplanted Recipients Treated …
Recent advances in the role of mammalian target of Rapamycin inhibitors on cardiac allograft vasculopathy
Activation of Mechanistic Target of Rapamycin (mTOR) in Human Endothelial Cells Infected with Pathogenic Spotted Fever Group Rickettsiae
Identification of a Novel Oxadiazole Inhibitor of Mammalian Target of Rapamycin
An inducible system for in vitro and in vivo Fas activation using FKBP-FRB-Rapamycin complex
Rapamycin attenuates gene expression of programmed cell death protein-ligand 1 and Foxp3 in the brain; a novel mechanism proposed for immunotherapy …
Prediction of Solanum lycopersicum Target of Rapamycin (SlTOR) Protein
Effect of In Vivo Expansion of Regulatory T Cells with IL-2/anti-IL-2 Antibody Complex Plus Rapamycin on Experimental Autoimmune Uveoretinitis
Therapy options after CDK4/6 inhibitors for HR+, HER2-postmenopausal metastatic/recurrent breast cancer in Japan: a role for mammalian target of Rapamycin …
Combination of Rapamycin and MK-2206 induced cell death via autophagy and necroptosis in MYCN-amplified neuroblastoma cell lines
Refractory systemic juvenile idiopathic arthritis successfully treated with Rapamycin
… Squamous Cell Carcinoma Growth Through Inactivation of Phosphoinositide 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) and ERK …
Long-term stability of 0.1% Rapamycin hydrophilic gel in the treatment of facial angiofibromas
Rapamycin-induced autophagy plays a pro-survival role by enhancing up-regulation of intracellular ferritin expression in acute lymphoblastic leukemia
Gambogic acid affects ribosomal occurrence in glioma cells by downregulating the phosphoinositide kinase-3/protein kinase b/mammalian target of Rapamycin …
… Conductance Ca2+-Activated K+ Channels in C2C12 Skeletal Muscle Cells Increases the Myotube Diameter via the Akt/Mammalian Target of Rapamycin Pathway
Pharmacokinetics of long-term low-dose oral Rapamycin in four healthy middle-aged companion dogs
Rapamycin Re-Directs Lysosome Network, Stimulates ER-Remodeling, Involving Membrane CD317 and Affecting Exocytosis, in Campylobacter Jejuni-Lysate …
The Mammalian Target of Rapamycin Complex 1 (mTORC1): An Ally of M. tuberculosis in Host Cells
… promotes gallbladder cancer proliferation and metastasis through activating phosphatidylinositol 3-kinase/protein kinase B/mammalian target of Rapamycin …
The long-term effects of Rapamycin-based immunosuppressive protocols on the expression of renal aquaporins 1, 2, 3 and 4 water channels in rats
Efficient Treatment of Atherosclerosis by Dexamethasone Acetate and Rapamycin Co-Loaded mPEG-DSPE Calcium Phosphate Nanoparticles
Characterization of Antineovascularization Activity and Ocular Pharmacokinetics of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GNE-947
Amino acids regulate energy utilization through mammalian target of Rapamycin complex 1 and adenosine monophosphate activated protein kinase pathway …
Mammalian target of Rapamycin is activated in the kidneys of patients with scleroderma renal crisis
Abstract B08: Improved tumor penetration, antitumor activity, and survival of ABI-009 (nab-sirolimus) versus oral Rapamycin and everolimus and investigation of mTOR …
High-dose Rapamycin excerts a temporary impact on T. reesei through gene trFKBP12
Effective and safe treatment of a novel IL2RA deficiency with Rapamycin
DNA methylation age analysis of Rapamycin in common marmosets
The use of Rapamycin to treat vascular tumours and malformations: A single-centre experience
Treatment of angiokeratomas of Fordyce with topical Rapamycin 0.25% cream
SUBCUTANEOUS IMPLANTATION OF Rapamycin IMPREGNATED SCAFFOLDS DEMONSTRATE THE POTENTIAL FOR LOCALISED ISLET GRAFT …
GENERATION OF STABLE HUMAN INDUCED REGULATORY T-CELLS REQUIRES OPTIMAL Rapamycin CONCENTRATION AND TCR STIMULATION
Effect of Calcineurin Inhibitors and Mammalian Target of Rapamycin Inhibitors on the Course of COVID-19 in Kidney Transplant Recipients
The Effects of Evening Primrose/Hemp Seed Oil Compared to Rapamycin on the Gene Expression of Immunological Parameters in Experimental Autoimmune …
Inhibitor for protein disulfide‑isomerase family A member 3 enhances the antiproliferative effect of inhibitor for mechanistic target of Rapamycin in liver cancer: An in …
Corrigendum to: Differential Effects of Rapamycin and Metformin in Combination With Rapamycin on Mechanisms of Proteostasis in Cultured Skeletal Myotubes
Treatment of port wine stain with Tixel‐induced Rapamycin delivery following pulsed dye laser application
Effects and potential mechanisms of Rapamycin on MPTP-induced acute Parkinson’s disease in mice.
In silico-based approach to investigate the ability of PEGylated Rapamycin to inhibit Galectin-3.
Metabolic control of lupus pathogenesis: central role for activation of the mechanistic target of Rapamycin
Can mammalian target of Rapamycin inhibitors replace mycophenolate in hypersensitized kidney transplant recipients?
Primary cutaneous peripheral T-cell lymphoma, not otherwise specified with mammalian target of Rapamycin mutation: A novel finding for targeted treatment
Hyperglycemia-induced VEGF and ROS production in retinal cells is inhibited by the mTOR inhibitor, Rapamycin
Gene Expression Regulation in the Mouse Liver by Mechanistic Target Of Rapamycin Complexes I and II
Effects of Glycerol and Shikimic Acid on Rapamycin Production in Streptomyces Rapamycinicus
… and Platelet-derived Growth Factor-stimulated Vascular Smooth Muscle Cell Proliferation via Inhibiting the Mammalian Target of Rapamycin/p70 S6 Kinase …
Spermidine and Rapamycin Reveal Distinct Autophagy Flux Response and Cargo Receptor Clearance Profile. Cells 2021, 10, 95
Anti-scarring effect of Rapamycin following filtering surgery in rabbit eyes
Correction for: Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance
Rapamycin PREVENTS INTERSTITIAL FIBROSIS THROUGH DECREASING PERITUBULAR CAPILLARY (PTC) VEGF EXPRESSION AND ANGIOGENESIS WHILE …
Characteristics of Rapamycin-treated T cell products for advanced adoptive T cell therapy and evaluation of clinical feasibility
Effects of Different Exercise Modes and Intensities on Skeletal Muscle Mammalian Target of Rapamycin Signaling in Strepto-zotocin and High-Fat-Diet Induced …
Correction: Therapeutic effects of Rapamycin and surgical decompression in a rabbit spinal cord injury model
Mammalian target of Rapamycin complexes: regulation and Alzheimer’s
Modulation of the Antidepressant Effects of Ketamine by the mTORC1 Inhibitor Rapamycin
Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic Rapamycin
Subcutaneous nanotherapy repurposes the immunosuppressive mechanism of Rapamycin to enhance allogeneic islet graft viability
The effect of Rapamycin on secretory activity of the rabbit ovarian fragments
Microspheres scar formation glaucoma filtration surgery area therapeutic effect—Based on Rapamycin-chitosan-calcium alginate sustained-release
Prenatal treatment with Rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down’s syndrome mouse model
Full Activation of Kinase Protein Kinase B by Phosphoinositide-Dependent Protein Kinase-1 and Mammalian Target of Rapamycin Complex 2 Is Required for …
Effect of Rapamycin on Canine Mast Cell Cancer Cells Following Radiation
Rapamycin-eluting Single and Double Stenting on Serum Markers in Coronary Bifurcation Lesions
Rapamycin Improves Recognition Memory and Normalizes Amino-Acids and Amines Levels in the Hippocampal Dentate Gyrus in Adult Rats Exposed to Ethanol …
The independent and combined effects of Rapamycin and metformin on naturally occurring osteoarthritis
… de la Lesión Hepática Inducida por Tioacetamida en ratas tratadas con Resveratrol: Rol de la vía de Señalización mTOR (mammalian Target of Rapamycin)
Autism spectrum disorder and mammalian target of Rapamycin system
Curcumin Promotes Recovery of Motor Function After Spinal Cord Injury in Rats Through Mammalian Target of Rapamycin (mTOR)-Signal Transducer and Activator of …
Study on the Treatment of Tuberous Sclerosis with Rapamycin Nanomicelles Based on Abdominal Ultrasound.
… Apoptosis of Gastric Cancer Cells via Phosphatidylinositol-3-Kinase (PI3K)/Protein Kinase B (Akt)/The Mammalian Target of Rapamycin (mTOR) Signaling Pathway
Mammalian Target of Rapamycin (mTOR) Inhibitors Induce Stomatitis in Patients with Metastatic Breast Cancer
Effect of adsorbing resins on the Rapamycin biosynthesis by Streptomyces hygroscopicus VKM Ac-2737D
The Effect of Forkhead Box Class O1, Mammalian Target of Rapamycin Complex 1, Survivin, and Interleukin-17 on the Degree of Acne Vulgaris Based on Serum …
Rapamycin as a potent and selective inhibitor of vascular endothelial growth factor receptor in breast carcinoma
Pharmacological treatment of Autoimmune Polyendocrine Syndrome type I with Rapamycin, a mTOR inhibitor
The role of salt inducible kinases in the regulation of the mammalian target of Rapamycin pathway in adipocytes
Rapamycin repairs damaged nerve cells and neurological function in rats with spinal cord injury through ERK signaling pathway.
Influence of an Early Application of Mammalian Target of Rapamycin Inhibitors Everolimus and Sirolimus on Acute Vascular Inflammatory Responses After Ischemia …
miR-34 Promotes Autophagy and Apoptosis of Spinal Chondrocytes by Mammalian Target of Rapamycin/Phosphatidylinositol-3-Kinase/Protein Kinase B Signaling
[Corrigendum] Rapamycin-induced autophagy activity promotes bone fracture healing in rats
The Interactions Between the Mechanistic Target of Rapamycin (mTOR) and the Microbiome
Sirtuins in mechanistic target of Rapamycin complex 1 signaling
Rapamycin-PLGA microspheres induce autophagy and prevent senescence in chondrocytes and exhibit long in vivo residence
Rapamycin alleviates experimental autoimmune hepatitis by immunoregulation of Th1 and Th17 cells
Apoptosis Activation in Thyroid Cancer Cells by Jatrorrhizine-Platinum (II) Complex via Downregulation of PI3K/AKT/Mammalian Target of Rapamycin (mTOR) …
Polyisoprenoids from Avicennia marina induces on P13k, Akt1, Mammalian target of Rapamycin, Egfr, and P53 Gene Expression Using Reverse Transcription …
Rapamycin proves both good and bad for aging in human cells
Repurposing metformin and Rapamycin to target age-related diseases
The new target of Rapamycin: lysosomal calcium channel TRPML1
THE EFFECT OF ENDURANCE TRAINING ON PROTEIN KINASE-B AND MECHANICAL TARGET OF Rapamycin IN THE LEFT VENTRICLE OF THE HEART OF …
inhibition of mammalian target of Rapamycin (mTOR) improves neurobehavioral deficit and modulates inflammatory response after traumatic brain injury
Targeting oxidative stress, transforming growth factor beta-1, and the mammalian target of Rapamycin by valproic acid to ameliorate bleomycin-induced …
… Inhibits Proliferation and Promotes Apoptosis of Ovarian Cancer Cells by Inactivating Phosphoinositide-3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin …
Is Rapamycin an Effective Anti-aging Drug?
inhibition of the Mammalian Target of Rapamycin Pathway Stimulates Osteoblast Proliferation and Differentiation Through Autophagy in MC3T3-E1 Cells
Abstract WP151: Rapamycin Improves Post-Recanalization Blood Flow After Acute Experimental Stroke in Rats
Combination Therapy with Rapamycin and Imatinib in Pulmonary Arterial Hypertension
The Involvement of the Mammalian Target of Rapamycin, Protein Tyrosine Phosphatase 1b and Dipeptidase 4 Signaling Pathways in Cancer and Diabetes: A …
Evaluation of the Effects of Rapamycin Treatment on Antioxidant Enzyme Changes and AgNOR in Testicular Torsion
… Spinal Cord Repair and Nerve Regeneration Through Phosphatidylinositol 3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin Signaling and Oxidative …
Effect of Rapamycin combined with nedaplatin in the treatment of bladder cancer and its influence on angiogenesis and invasion
Effect of glucose, soya oil and glutamine on protein expression and mammalian target of Rapamycin complex 1 pathway of jejunal crypt enterocytes in weaned piglets
The Effect of Rapamycin and Metformin Treatment on Primary OA Pathology
Mammalian target of Rapamycin complexes: protein synthesis and autophagy, Parkinson’s disease, amyotrophic lateral sclerosis, and frontotemporal dementia
The effect of mTOR inhibitor Rapamycin on a dietary Drosophila melanogaster model of calcium oxalate nephrolithiasis
Abstract A28: Rapamycin-upregulated miR-29b promotes mTORC1-hyperactivative cell growth by downregulating retinoic acid receptor β (RARβ)
Mammalian target of Rapamycin inhibitors after post-transplant hepatocellular carcinoma recurrence: Is it too late?
Interleukin-27 decreases ghrelin production through signal transducer and activator of transcription 3—mechanistic target of Rapamycin signaling
Combined application of Rapamycin and atorvastatin improves lipid metabolism in apolipoprotein E-deficient mice with chronic kidney disease.
Effect of mammalian target of Rapamycin on cognitive dysfunction of Alzheimer’s Disease via regulating Homer3
Impact of Rapamycin on Secondary Infection of Laboratory Mice (Mus musculus) with the Intestinal Nematode Heligmosomoides bakeri
Evaluation of TGF-beta, Rapamycin, and IL-2 microparticle (TRI MP) treatment for disease prevention in models of type 1 diabetes and arthritis
Cell Synchronization by Rapamycin Improves the Developmental Competence of Buffalos (Bubalus bubalis) SCNT Embryos.
Corrigendum to” Rapamycin Reverses TLR4 Signaling-Triggered Tumor Apoptosis Resistance by Disrupting Akt-mediated Bcl-xL Upregulation”[Int …
publisher correction: Regulation of protein kinase cδ nuclear import and Apoptosis by Mechanistic Target of Rapamycin Complex-1
… the Proliferation of Human Ovarian Cancer Cells In Vitro via the Phosphatidylinositol-3-Kinase (PI3K)/Akt and the Mammalian Target of Rapamycin (mTOR) and Wnt/β …
Correction: Rapamycin increases CCN2 expression of lung fibroblasts via phosphoinositide 3-kinase
Rapamycin prevents the impairments of social recognition induced by anti-P antibody in a murine model
Supporting Data for” Identification of Novel Components of Target-of-Rapamycin Signaling Pathway by Network-Based Multi-Omics Integrative Analysis”
Rapamycin eluting stent implantation in the treatment of total coronary artery occlusion in a case of Kawasaki disease
Investigation of the Effects of mTOR Inhibitors Rapamycin and Everolimus in Combination with Carboplatin on Canine Malignant Melanoma Cells.
Rapamycin alleviates the symptoms of experimental autoimmune myasthenia gravis rats by down-regulating Th17 cell/regulatory T cell ratio
235 Effects of Rapamycin during an acute heat stress exposure in growing pigs
Rapamycin and Rapalogs for Tuberous Sclerosis Complex: Updates on Studies’ and Outcomes’ Characteristics of a Cochrane Systematic Review
… : Activation of autophagic flux against xenoestrogen bisphenol-A-Induced hippocampal neurodegeneration via AMP kinase (AMPK)/mammalian target of Rapamycin …
inhibition of mammalian target of Rapamycin (mTOR) improves neurobehavioral deficit and modulates inflammatory response after traumatic brain injury
Combination Therapy of Sildenafil and Rapamycin Alleviates Doxorubicin Induced Cardiotoxicity With Improvement of Skeletal Muscle Function
Rapamycin ON THE TREATMENT OF MUCOEPIDERMOID CARCINOMAS AND SQUAMOUS CELL CARCINOMAS
Amino Acid Sensing Ability by the Mechanistic Target of Rapamycin in Oligodendrocytes
Rescue of Lipid-Induced Autophagy inhibition by Rapamycin Treatment
Rapamycin‐Dependent Gln3 Transcription Factor Dephosphorylation and Nuclear Localization Depend On Distinct Regions of the Gln3 Protein
Evaluation of S100A9 targeted nanoparticles containing Rapamycin to treat pancreatic adenocarcinoma
… Cells In Vitro and in Mouse Tumor Xenografts and Activates Autophagy and Apoptosis by Downregulation of the Mammalian Target of Rapamycin (mTOR)/PI3K/AKT …
… Shenzhu Tiaopi granule on hepatic insulin resistance in diabetic Goto-Kakizakirats via liver kinase B1/adenosine 5′-monophosphate/mammalian target of Rapamycin …
Retracted: inhibition of Nasopharyngeal Carcinoma by Beta-Lapachone Occurs by Targeting the Mammalian Target of Rapamycin (mTOR)/PI3K/AKT Pathway …
Correction: Alternative mammalian target of Rapamycin (mTOR) signal activation in sorafenib-resistant hepatocellular carcinoma cells revealed by array-based …
Mechanistic Target of Rapamycin, but Not the Integrated Stress Response, Promotes ATF4-Dependent Metabolic Reprogramming in TGF-β-Treated Lung Fibroblasts
… Protein of Mammalian Target or Rapamycin mRNA (RPTOR) and Rapamycin‐insensitive Companion of Mammalian Target of Rapamycin (RICTR) messenger RNA
Rapamycin inhibits colorectal cancer progression through down-regulating mTOR-GP73 pathway
Abstract PS14-17: Rapamycin inhibits stem cell function and diminishes inflammation and senescence markers in human mammary gland
Intermittent Fasting (IF) Promotes Longevity through Alterations of the Mammalian Target of Rapamycin (mTOR) and the Epigenome
Rapamycin-based GVHD prophylaxis increases the immunosuppressivity of MDSCs without affecting T cells and anti-tumor cytotoxicity.
Effects of Quercetin on Autophagy and Phosphatidylinositol 3-kinase/Protein Kinase B/Mammalian Target of Rapamycin Signaling Pathway in Human Prostate Cancer …
The effect of high intensity interval training on complex mammalian target of Rapamycin 1 (mTORC1) pathway in Flexor hallucis longus muscle (FHL) of …
Six-year angiographic follow-up of a chronic total coronary occlusion successfully treated with BMS implantation followed by oral Rapamycin
Maf1 suppression of ATF5-dependent mitochondrial unfolded protein response contributes to Rapamycin-induced radio-sensitivity in lung cancer cell line A549.
COMPARISON OF Rapamycin WITH CYCLOSPORIN, AND TACROLIMUS IN REGARDS TO THE DEVELOPMENT OF EPITHELIAL-TO-MESENCHYMAL …
Abstract PS16-18: inhibition of mTOR signaling by Rapamycin abrogates mammary stem/progenitor cell activity in aged mice
Rapamycin does not reproduce the alterations to Caco‐2 transepithelial electrical resistance caused by the knockdown of Raptor
Oral preconditioning of donors after brain death with calcineurin inhibitors vs. inhibitors of mammalian target for Rapamycin in pig kidney transplantation
Rapamycin immune tolerization enables gene transfer following subcutaneous delivery of AAV6 but not CD4-retargeted AAV6 vectors in AAV-seropositive …
mTOR Inhibitor Rapamycin can reverses the combination antiretroviral therapy induced central nervous system disorder
Corrigendum to” Rapamycin suppresses TLR4-triggered IL-6 and PGE 2 production of colon cancer cells by inhibiting TLR4 expression and NF-κB activation”[Mol …
Rapamycin and chloroquine insensitivity reveal mTORC1‐independent regulation of epithelial permeability in differentiated intestinal Caco‐2 cells
… -4-one (PP-4-one) Exhibits Anti-Epileptogenic Effect in Rat Model of Traumatic Epilepsy by Mammalian Target of Rapamycin (mTOR) Signaling Pathway …
Mammalian Target of Rapamycin Mediates Expression and Activity of ADAM 17 in Diabetic Kidney Disease
Gattino, F; Biolatti, B; Sasaki, N; Nakagawa, T; Di Renzo, Mf; de Las Mulas, Jm; De Maria, R.. Activation of mammalian target of Rapamycin (mTOR) in triple …
Gorham-Stout disease successfully treated with sirolimus (Rapamycin): a case report and review of the literature
Age-dependent effects of short-term intermittent fasting and Rapamycin treatment in Zebrafish (Danio Rerio) brain
Molecular Dynamic Simulations for Mammalian Target of Rapamycin (mTOR) Variants to Characterize Potential Disruption of Porphyromonas gingivalis Induced …
Defining the properties of the OS-33 osteosarcoma cell line and the effects of mTORC1 inhibition by Rapamycin treatment
Deletion of the mechanistic‐target‐of‐Rapamycin (mTOR) from collecting duct principal associated with increased ubiquitinylation of epithelial sodium channel (ENaC)
Construction of lentiviral vector for late endosomal/lysosomal adaptor, mitogen-activated protein kinase and mammalian target of Rapamycin activator 2 interference …
85 Regulation of mammalian target of Rapamycin signaling post-fertilisation is essential for efficient development of bovine pre-implantation embryos
… SUPPRESSES SQUAMOUS DIFFERENTIATION OF BLADDER CANCER AND CANCER GROWTH VIA REGULATION OF MAMMALIAN TARGET OF Rapamycin …
Abstract A16: Suppressor of morphogenesis in genitalia 1 (SMG1) is a novel negative regulator of mammalian target of Rapamycin complex 2 (mTORC2)
… by Chemokine (CC Motif) Ligand 3 Promote the Progression of Breast Cancer via Phosphoinositide 3-Kinase-Protein Kinase B-Mammalian Target of Rapamycin …
… Contributes to Esophageal Squamous Cell Carcinoma Progression via CCR8-Mediated Akt/Proline-Rich Akt Substrate of 40 kDa/Mammalian Target of Rapamycin …
69 Phosphorylation of mechanistic target of Rapamycin in porcine blastocyst-stage embryos is dependent on the concentration of glutamine in the medium

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