January 4, 2020
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P53

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis Human SIR2 deacetylates p53 and antagonizes PML/p53‐induced cellular senescence Senescence and tumour clearance is triggered […]
January 6, 2020
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HSP90

Hsp90 (heat shock protein 90) is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against heat stress, and aids in protein degradation. It also stabilizes a number of proteins […]
January 7, 2020
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TELOMERE SHORTENING & PREMATURE AGING

A branching process model of telomere shortening A continuous correlation between oxidative stress and telomere shortening in fibroblasts A Critical Role for Pin2/TRF1 in ATM-dependent Regulation […]
January 7, 2020
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PREMATURE SENESCENCE

Premature Senescence ”Senescence is more than merely a cell division clock that regulates the proliferative lifespan of normal cells. “Premature” senescence is an active cytostaticprogram that […]
January 7, 2020
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JAK INHIBITION ALLEVIATES SASP

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age A hallmark of aging is chronic sterile inflammation, which is closely associated with […]
January 8, 2020
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Oncogene Activation

… : VersicanV1 promotes proliferation and metastasis of hepatocellular carcinoma through the activation of EGFR–PI3K–AKT pathway (oncogene,(2018), 37, 41,(5585 … … and functional interaction between polyoma […]
January 10, 2020
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JNK PREVENTS PREMATURE SENESCENCE

Prevention of premature senescence requires JNK activation Premature senescence is considered as a cellular defense mechanism to prevent tumorigenesis. Although recent evidences show that c-Jun N-terminal […]
January 10, 2020
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MDM2

MDM2 antagonists attenuate the senescence-associated secretory phenotype Processes that have been linked to aging and cancer include an inflammatory milieu driven by senescent cells. Senescent cells […]
January 14, 2020
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SENESCENT CELLS, SASP & SENOLYTICS

SHIPPING APRIL 15TH!!! ZOMBIE CELL KILLER   News Articles:  Both Senolytic Molecules Are Inhibitors Of Particular Members Of The Bcl-2 Family Of Apoptosis Regulatory Proteins And […]